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SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for HMGA2

Z-value: 0.56

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Transcription factors associated with HMGA2

Gene Symbol Gene ID Gene Info
HMGA2
ENSG00000149948.9 high mobility group AT-hook 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HMGA2hg19_v2_chr12_+_66218903_66218913-0.642.2e-03Click!

Activity profile of HMGA2 motif

Sorted Z-values of HMGA2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_+_193853927 1.57 ENST00000232424.3
HES1
hes family bHLH transcription factor 1
chr1_+_196621002 1.46 ENST00000367429.4
ENST00000439155.2
CFH
complement factor H
chr1_+_196621156 0.93 ENST00000359637.2
CFH
complement factor H
chr19_-_36297632 0.92 ENST00000588266.2
PRODH2
proline dehydrogenase (oxidase) 2
chr19_+_11457175 0.86 ENST00000458408.1
ENST00000586451.1
ENST00000588592.1
CCDC159
coiled-coil domain containing 159
chr15_+_43985084 0.75 ENST00000434505.1
ENST00000411750.1
CKMT1A
creatine kinase, mitochondrial 1A
chr2_-_216257849 0.73 ENST00000456923.1
FN1
fibronectin 1
chr15_+_43885252 0.73 ENST00000453782.1
ENST00000300283.6
ENST00000437924.1
ENST00000450086.2
CKMT1B
creatine kinase, mitochondrial 1B
chrX_+_2670066 0.72 ENST00000381174.5
ENST00000419513.2
ENST00000426774.1
XG
Xg blood group
chr1_+_104104379 0.67 ENST00000435302.1
AMY2B
amylase, alpha 2B (pancreatic)
chr15_+_84904525 0.60 ENST00000510439.2
GOLGA6L4
golgin A6 family-like 4
chr1_+_2487800 0.47 ENST00000355716.4
TNFRSF14
tumor necrosis factor receptor superfamily, member 14
chrX_-_7895755 0.44 ENST00000444736.1
ENST00000537427.1
ENST00000442940.1
PNPLA4
patatin-like phospholipase domain containing 4
chrX_+_135614293 0.42 ENST00000370634.3
VGLL1
vestigial like 1 (Drosophila)
chr12_-_10573149 0.42 ENST00000381904.2
ENST00000381903.2
ENST00000396439.2
KLRC3
killer cell lectin-like receptor subfamily C, member 3
chr3_+_121774202 0.41 ENST00000469710.1
ENST00000493101.1
ENST00000330540.2
ENST00000264468.5
CD86
CD86 molecule
chr19_+_41882466 0.38 ENST00000436170.2
TMEM91
transmembrane protein 91
chrX_-_7895479 0.36 ENST00000381042.4
PNPLA4
patatin-like phospholipase domain containing 4
chr19_+_44455368 0.36 ENST00000591168.1
ENST00000587682.1
ENST00000251269.5
ZNF221
zinc finger protein 221
chrX_+_1710484 0.33 ENST00000313871.3
ENST00000381261.3
AKAP17A
A kinase (PRKA) anchor protein 17A
chr15_+_83098710 0.32 ENST00000561062.1
ENST00000358583.3
GOLGA6L9
golgin A6 family-like 20
chrX_-_71792477 0.31 ENST00000421523.1
ENST00000415409.1
ENST00000373559.4
ENST00000373556.3
ENST00000373560.2
ENST00000373583.1
ENST00000429103.2
ENST00000373571.1
ENST00000373554.1
HDAC8
histone deacetylase 8
chr6_+_88106840 0.30 ENST00000369570.4
C6orf164
chromosome 6 open reading frame 164
chr17_-_26220366 0.30 ENST00000460380.2
ENST00000508862.1
ENST00000379102.3
ENST00000582441.1
LYRM9
RP1-66C13.4
LYR motif containing 9
Uncharacterized protein
chr9_+_42704004 0.28 ENST00000457288.1
CBWD7
COBW domain containing 7
chr15_-_82939157 0.28 ENST00000559949.1
RP13-996F3.5
golgin A6 family-like 18
chr11_+_73661364 0.28 ENST00000339764.1
DNAJB13
DnaJ (Hsp40) homolog, subfamily B, member 13
chr15_+_82722225 0.27 ENST00000300515.8
GOLGA6L9
golgin A6 family-like 9
chr6_-_32908792 0.27 ENST00000418107.2
HLA-DMB
major histocompatibility complex, class II, DM beta
chr6_+_111580508 0.25 ENST00000368847.4
KIAA1919
KIAA1919
chr10_-_62332357 0.25 ENST00000503366.1
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr2_+_220143989 0.25 ENST00000336576.5
DNAJB2
DnaJ (Hsp40) homolog, subfamily B, member 2
chr1_+_144989309 0.25 ENST00000596396.1
AL590452.1
Uncharacterized protein
chrX_+_2670153 0.24 ENST00000509484.2
XG
Xg blood group
chr20_+_48884002 0.24 ENST00000425497.1
ENST00000445003.1
RP11-290F20.3
RP11-290F20.3
chr12_-_10541575 0.23 ENST00000540818.1
KLRK1
killer cell lectin-like receptor subfamily K, member 1
chr19_-_11456722 0.23 ENST00000354882.5
TMEM205
transmembrane protein 205
chr19_-_12267524 0.23 ENST00000455799.1
ENST00000355738.1
ENST00000439556.2
ENST00000542938.1
ZNF625
zinc finger protein 625
chr6_+_116892641 0.22 ENST00000487832.2
ENST00000518117.1
RWDD1
RWD domain containing 1
chr3_-_106959424 0.22 ENST00000607801.1
ENST00000479612.2
ENST00000484698.1
ENST00000477210.2
ENST00000473636.1
LINC00882
long intergenic non-protein coding RNA 882
chr4_-_299110 0.22 ENST00000419098.1
ZNF732
zinc finger protein 732
chr15_-_83018198 0.22 ENST00000557886.1
RP13-996F3.4
golgin A6 family-like 19
chr19_-_11457082 0.22 ENST00000587948.1
TMEM205
transmembrane protein 205
chrX_-_134186144 0.21 ENST00000370775.2
FAM127B
family with sequence similarity 127, member B
chr1_+_2487631 0.20 ENST00000409119.1
TNFRSF14
tumor necrosis factor receptor superfamily, member 14
chr18_+_11851383 0.20 ENST00000526991.2
CHMP1B
charged multivesicular body protein 1B
chr19_-_11457162 0.20 ENST00000590482.1
TMEM205
transmembrane protein 205
chr19_-_11456935 0.19 ENST00000590788.1
ENST00000586590.1
ENST00000589555.1
ENST00000586956.1
ENST00000593256.2
ENST00000447337.1
ENST00000591677.1
ENST00000586701.1
ENST00000589655.1
TMEM205
RAB3D
transmembrane protein 205
RAB3D, member RAS oncogene family
chr8_-_105479270 0.19 ENST00000521573.2
ENST00000351513.2
DPYS
dihydropyrimidinase
chr11_-_130786400 0.18 ENST00000265909.4
SNX19
sorting nexin 19
chr2_-_239140011 0.18 ENST00000409376.1
ENST00000409070.1
ENST00000409942.1
AC016757.3
Protein LOC151174
chr14_+_99947715 0.17 ENST00000389879.5
ENST00000557441.1
ENST00000555049.1
ENST00000555842.1
CCNK
cyclin K
chr14_+_50291993 0.17 ENST00000595378.1
AL627171.2
HCG1786899; PRO2610; Uncharacterized protein
chrX_+_2924654 0.17 ENST00000381130.2
ARSH
arylsulfatase family, member H
chr12_+_65996599 0.16 ENST00000539116.1
ENST00000541391.1
RP11-221N13.3
RP11-221N13.3
chr11_+_67250490 0.16 ENST00000528641.2
ENST00000279146.3
AIP
aryl hydrocarbon receptor interacting protein
chr5_+_36608422 0.16 ENST00000381918.3
SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr6_-_32908765 0.16 ENST00000416244.2
HLA-DMB
major histocompatibility complex, class II, DM beta
chr3_+_186501336 0.16 ENST00000323963.5
ENST00000440191.2
ENST00000356531.5
EIF4A2
eukaryotic translation initiation factor 4A2
chr14_-_65409438 0.16 ENST00000557049.1
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr2_+_177134134 0.16 ENST00000249442.6
ENST00000392529.2
ENST00000443241.1
MTX2
metaxin 2
chr6_+_123110302 0.16 ENST00000368440.4
SMPDL3A
sphingomyelin phosphodiesterase, acid-like 3A
chr2_-_114461655 0.16 ENST00000424612.1
AC017074.2
AC017074.2
chrY_+_22918021 0.16 ENST00000288666.5
RPS4Y2
ribosomal protein S4, Y-linked 2
chr2_-_287299 0.15 ENST00000405290.1
FAM150B
family with sequence similarity 150, member B
chr2_+_13677795 0.15 ENST00000434509.1
AC092635.1
AC092635.1
chr12_+_96196875 0.15 ENST00000553095.1
RP11-536G4.1
Uncharacterized protein
chr14_+_37641012 0.15 ENST00000556667.1
SLC25A21-AS1
SLC25A21 antisense RNA 1
chr11_-_18063973 0.15 ENST00000528338.1
TPH1
tryptophan hydroxylase 1
chr21_-_31852663 0.14 ENST00000390689.2
KRTAP19-1
keratin associated protein 19-1
chr14_-_94759408 0.14 ENST00000554723.1
SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr15_+_58702742 0.14 ENST00000356113.6
ENST00000414170.3
LIPC
lipase, hepatic
chr1_-_67600639 0.14 ENST00000544837.1
ENST00000603691.1
C1orf141
chromosome 1 open reading frame 141
chr8_+_9911778 0.14 ENST00000317173.4
ENST00000441698.2
MSRA
methionine sulfoxide reductase A
chr14_-_94759595 0.13 ENST00000261994.4
SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr14_+_88852059 0.13 ENST00000045347.7
SPATA7
spermatogenesis associated 7
chr10_+_90484301 0.13 ENST00000404190.1
LIPK
lipase, family member K
chr5_-_135290705 0.12 ENST00000274507.1
LECT2
leukocyte cell-derived chemotaxin 2
chr5_+_67485704 0.12 ENST00000520762.1
RP11-404L6.2
Uncharacterized protein
chr14_-_94759361 0.12 ENST00000393096.1
SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr15_-_32747835 0.12 ENST00000509311.2
ENST00000414865.2
GOLGA8O
golgin A8 family, member O
chr5_-_135290651 0.12 ENST00000522943.1
ENST00000514447.2
LECT2
leukocyte cell-derived chemotaxin 2
chr1_+_2487402 0.11 ENST00000451778.1
TNFRSF14
tumor necrosis factor receptor superfamily, member 14
chr14_+_45553296 0.11 ENST00000355765.6
ENST00000553605.1
PRPF39
pre-mRNA processing factor 39
chr2_-_183387430 0.11 ENST00000410103.1
PDE1A
phosphodiesterase 1A, calmodulin-dependent
chr2_-_183387283 0.11 ENST00000435564.1
PDE1A
phosphodiesterase 1A, calmodulin-dependent
chr20_+_9966728 0.10 ENST00000449270.1
RP5-839B4.8
RP5-839B4.8
chr12_+_18414446 0.10 ENST00000433979.1
PIK3C2G
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma
chr19_-_11456872 0.09 ENST00000586218.1
TMEM205
transmembrane protein 205
chr19_-_11456905 0.09 ENST00000588560.1
ENST00000592952.1
TMEM205
transmembrane protein 205
chr7_+_80267973 0.09 ENST00000394788.3
ENST00000447544.2
CD36
CD36 molecule (thrombospondin receptor)
chr10_-_129691195 0.09 ENST00000368671.3
CLRN3
clarin 3
chr2_-_183387064 0.08 ENST00000536095.1
ENST00000331935.6
ENST00000358139.2
ENST00000456212.1
PDE1A
phosphodiesterase 1A, calmodulin-dependent
chr12_-_21757774 0.08 ENST00000261195.2
GYS2
glycogen synthase 2 (liver)
chrX_-_153523462 0.07 ENST00000361930.3
ENST00000369926.1
TEX28
testis expressed 28
chr2_+_220144052 0.07 ENST00000425450.1
ENST00000392086.4
ENST00000421532.1
DNAJB2
DnaJ (Hsp40) homolog, subfamily B, member 2
chr7_+_80275953 0.07 ENST00000538969.1
ENST00000544133.1
ENST00000433696.2
CD36
CD36 molecule (thrombospondin receptor)
chr12_-_8765446 0.07 ENST00000537228.1
ENST00000229335.6
AICDA
activation-induced cytidine deaminase
chr9_-_86955598 0.07 ENST00000376238.4
SLC28A3
solute carrier family 28 (concentrative nucleoside transporter), member 3
chr9_-_34397800 0.06 ENST00000297623.2
C9orf24
chromosome 9 open reading frame 24
chr12_-_10324716 0.06 ENST00000545927.1
ENST00000432556.2
ENST00000309539.3
ENST00000544577.1
OLR1
oxidized low density lipoprotein (lectin-like) receptor 1
chr7_-_102985288 0.06 ENST00000379263.3
DNAJC2
DnaJ (Hsp40) homolog, subfamily C, member 2
chrX_-_128782722 0.05 ENST00000427399.1
APLN
apelin
chr1_+_55464600 0.05 ENST00000371265.4
BSND
Bartter syndrome, infantile, with sensorineural deafness (Barttin)
chr12_+_8309630 0.05 ENST00000396570.3
ZNF705A
zinc finger protein 705A
chr2_-_287320 0.05 ENST00000401503.1
FAM150B
family with sequence similarity 150, member B
chr1_-_76398077 0.04 ENST00000284142.6
ASB17
ankyrin repeat and SOCS box containing 17
chr17_-_50236039 0.04 ENST00000451037.2
CA10
carbonic anhydrase X
chr3_-_123680246 0.04 ENST00000488653.2
CCDC14
coiled-coil domain containing 14
chr2_+_1417228 0.04 ENST00000382269.3
ENST00000337415.3
ENST00000345913.4
ENST00000346956.3
ENST00000349624.3
ENST00000539820.1
ENST00000329066.4
ENST00000382201.3
TPO
thyroid peroxidase
chr6_+_106535455 0.04 ENST00000424894.1
PRDM1
PR domain containing 1, with ZNF domain
chr17_-_4607335 0.03 ENST00000570571.1
ENST00000575101.1
ENST00000436683.2
ENST00000574876.1
PELP1
proline, glutamate and leucine rich protein 1
chr2_+_177134201 0.03 ENST00000452865.1
MTX2
metaxin 2
chr2_-_130031335 0.03 ENST00000375987.3
AC079586.1
AC079586.1
chr1_+_197886461 0.03 ENST00000367388.3
ENST00000337020.2
ENST00000367387.4
LHX9
LIM homeobox 9
chrX_-_23926004 0.03 ENST00000379226.4
ENST00000379220.3
APOO
apolipoprotein O
chr15_+_88120158 0.02 ENST00000560153.1
LINC00052
long intergenic non-protein coding RNA 52
chr9_+_2157655 0.01 ENST00000452193.1
SMARCA2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr3_-_157221128 0.01 ENST00000392833.2
ENST00000362010.2
VEPH1
ventricular zone expressed PH domain-containing 1
chr18_-_29340827 0.01 ENST00000269205.5
SLC25A52
solute carrier family 25, member 52
chr14_-_65409502 0.01 ENST00000389614.5
GPX2
glutathione peroxidase 2 (gastrointestinal)
chrX_-_77150985 0.00 ENST00000358075.6
MAGT1
magnesium transporter 1

Network of associatons between targets according to the STRING database.

First level regulatory network of HMGA2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.6 GO:0042668 auditory receptor cell fate determination(GO:0042668) negative regulation of auditory receptor cell differentiation(GO:0045608) regulation of timing of neuron differentiation(GO:0060164) negative regulation of pro-B cell differentiation(GO:2000974)
0.2 0.7 GO:1904237 regulation of substrate-dependent cell migration, cell attachment to substrate(GO:1904235) positive regulation of substrate-dependent cell migration, cell attachment to substrate(GO:1904237)
0.1 0.4 GO:2001190 positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:2001190)
0.1 0.4 GO:0002644 negative regulation of tolerance induction(GO:0002644) positive regulation of interleukin-4 biosynthetic process(GO:0045404)
0.1 0.9 GO:0010133 proline catabolic process to glutamate(GO:0010133)
0.1 0.3 GO:0071922 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.1 2.4 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.1 0.8 GO:0046642 negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.1 0.2 GO:2000502 negative regulation of natural killer cell chemotaxis(GO:2000502)
0.1 0.3 GO:1903644 regulation of chaperone-mediated protein folding(GO:1903644)
0.1 0.4 GO:0008218 bioluminescence(GO:0008218)
0.1 0.3 GO:1904158 axonemal central apparatus assembly(GO:1904158)
0.0 0.2 GO:0006210 pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) beta-alanine metabolic process(GO:0019482) thymine metabolic process(GO:0019859) uracil metabolic process(GO:0019860)
0.0 0.7 GO:0006600 creatine metabolic process(GO:0006600)
0.0 0.2 GO:0072660 maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.0 0.2 GO:0018125 peptidyl-cysteine methylation(GO:0018125)
0.0 0.2 GO:0044828 negative regulation by host of viral genome replication(GO:0044828)
0.0 0.2 GO:2000825 positive regulation of androgen receptor activity(GO:2000825)
0.0 0.1 GO:0042427 serotonin biosynthetic process(GO:0042427)
0.0 0.1 GO:0043396 corticotropin-releasing hormone secretion(GO:0043396) regulation of corticotropin-releasing hormone secretion(GO:0043397) positive regulation of corticotropin-releasing hormone secretion(GO:0051466)
0.0 0.9 GO:0019433 triglyceride catabolic process(GO:0019433)
0.0 0.2 GO:0051344 regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051342) negative regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051344)
0.0 0.3 GO:0046069 cGMP catabolic process(GO:0046069)
0.0 0.2 GO:0070779 gamma-aminobutyric acid biosynthetic process(GO:0009449) D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0 0.2 GO:0072564 blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334)
0.0 0.1 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.0 0.0 GO:1990654 sebum secreting cell proliferation(GO:1990654)
0.0 0.2 GO:1904896 ESCRT complex disassembly(GO:1904896) ESCRT III complex disassembly(GO:1904903)
0.0 0.2 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.0 0.1 GO:0015855 pyrimidine nucleobase transport(GO:0015855) purine nucleobase transmembrane transport(GO:1904823)
0.0 0.1 GO:0030091 protein repair(GO:0030091)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0002945 cyclin K-CDK12 complex(GO:0002944) cyclin K-CDK13 complex(GO:0002945)
0.1 0.7 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.2 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.0 0.4 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 2.4 GO:0072562 blood microparticle(GO:0072562)
0.0 0.2 GO:0000815 ESCRT III complex(GO:0000815)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0004657 proline dehydrogenase activity(GO:0004657)
0.2 0.8 GO:0050253 retinyl-palmitate esterase activity(GO:0050253)
0.1 0.7 GO:0004556 alpha-amylase activity(GO:0004556)
0.1 2.4 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.1 0.7 GO:0004111 creatine kinase activity(GO:0004111)
0.0 0.3 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.0 0.2 GO:0002054 nucleobase binding(GO:0002054) dihydropyrimidinase activity(GO:0004157)
0.0 0.1 GO:0030627 pre-mRNA 5'-splice site binding(GO:0030627)
0.0 0.1 GO:0004510 tryptophan 5-monooxygenase activity(GO:0004510)
0.0 0.1 GO:0008113 peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.0 0.8 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 0.1 GO:0015389 pyrimidine- and adenine-specific:sodium symporter activity(GO:0015389)
0.0 0.2 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.0 2.6 GO:0051087 chaperone binding(GO:0051087)
0.0 0.2 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
0.0 0.4 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.0 0.2 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.6 PID FANCONI PATHWAY Fanconi anemia pathway
0.0 0.7 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.4 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.0 0.7 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.0 1.6 REACTOME REGULATION OF BETA CELL DEVELOPMENT Genes involved in Regulation of beta-cell development
0.0 0.7 REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0 0.4 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 0.2 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism