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SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for HNF1A_HNF1B
Z-value: 5.64
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Transcription factors associated with HNF1A_HNF1B
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HNF1A | hg19_v2_chr12_+_121416340_121416371 | 0.94 | 5.9e-10 | Click! |
| HNF1B | hg19_v2_chr17_-_36105009_36105060 | 0.82 | 1.1e-05 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of HNF1A_HNF1B
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.9 | 110.5 | GO:0043152 | induction of bacterial agglutination(GO:0043152) |
| 8.1 | 105.9 | GO:0019375 | galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375) |
| 13.3 | 79.7 | GO:1903412 | response to bile acid(GO:1903412) |
| 4.3 | 51.4 | GO:0034392 | negative regulation of smooth muscle cell apoptotic process(GO:0034392) |
| 4.8 | 48.3 | GO:2000189 | positive regulation of cholesterol homeostasis(GO:2000189) |
| 1.4 | 47.1 | GO:0043567 | regulation of insulin-like growth factor receptor signaling pathway(GO:0043567) |
| 14.0 | 41.9 | GO:0016999 | antibiotic metabolic process(GO:0016999) |
| 6.1 | 36.9 | GO:0010760 | negative regulation of macrophage chemotaxis(GO:0010760) |
| 0.3 | 36.5 | GO:0032411 | positive regulation of transporter activity(GO:0032411) |
| 5.2 | 36.4 | GO:0010133 | proline catabolic process to glutamate(GO:0010133) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 9.4 | 132.0 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.1 | 105.6 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.1 | 79.3 | GO:0030133 | transport vesicle(GO:0030133) |
| 0.1 | 58.0 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.1 | 48.5 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.0 | 47.4 | GO:0005654 | nucleoplasm(GO:0005654) |
| 2.6 | 46.7 | GO:0031089 | platelet dense granule lumen(GO:0031089) |
| 0.1 | 40.3 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 3.3 | 39.9 | GO:0046581 | intercellular canaliculus(GO:0046581) |
| 4.6 | 36.9 | GO:0005579 | membrane attack complex(GO:0005579) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 8.8 | 105.9 | GO:0001733 | galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694) |
| 6.6 | 79.7 | GO:0005007 | fibroblast growth factor-activated receptor activity(GO:0005007) |
| 0.4 | 70.6 | GO:0051087 | chaperone binding(GO:0051087) |
| 3.4 | 47.1 | GO:0031995 | insulin-like growth factor II binding(GO:0031995) |
| 9.4 | 46.8 | GO:0060230 | lipoprotein lipase activator activity(GO:0060230) |
| 0.8 | 46.5 | GO:0005504 | fatty acid binding(GO:0005504) |
| 2.2 | 41.1 | GO:0043225 | anion transmembrane-transporting ATPase activity(GO:0043225) |
| 1.3 | 37.6 | GO:0017081 | chloride channel regulator activity(GO:0017081) |
| 9.1 | 36.4 | GO:0004657 | proline dehydrogenase activity(GO:0004657) |
| 0.8 | 36.1 | GO:0008009 | chemokine activity(GO:0008009) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 113.5 | PID EPHRINB REV PATHWAY | Ephrin B reverse signaling |
| 0.9 | 83.4 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.7 | 79.2 | PID FGF PATHWAY | FGF signaling pathway |
| 0.1 | 35.8 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.3 | 29.5 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.1 | 29.4 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.4 | 25.4 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 0.4 | 16.8 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.2 | 16.2 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.2 | 13.7 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.8 | 117.0 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 1.5 | 105.9 | REACTOME GLYCOSPHINGOLIPID METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 4.7 | 79.7 | REACTOME FGFR4 LIGAND BINDING AND ACTIVATION | Genes involved in FGFR4 ligand binding and activation |
| 1.5 | 78.1 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
| 2.0 | 51.9 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 1.1 | 48.3 | REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.8 | 41.1 | REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT | Genes involved in ABC-family proteins mediated transport |
| 0.6 | 31.3 | REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.3 | 30.6 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.4 | 28.1 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |