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SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for HNF1A_HNF1B

Z-value: 5.64

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Transcription factors associated with HNF1A_HNF1B

Gene Symbol Gene ID Gene Info
HNF1A
ENSG00000135100.13 HNF1 homeobox A
HNF1B
ENSG00000108753.8 HNF1 homeobox B

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HNF1Ahg19_v2_chr12_+_121416340_1214163710.945.9e-10Click!
HNF1Bhg19_v2_chr17_-_36105009_361050600.821.1e-05Click!

Activity profile of HNF1A_HNF1B motif

Sorted Z-values of HNF1A_HNF1B motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr17_-_64225508 46.77 ENST00000205948.6
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr10_+_101542462 41.10 ENST00000370449.4
ENST00000370434.1
ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr4_-_155511887 40.74 ENST00000302053.3
ENST00000403106.3
FGA
fibrinogen alpha chain
chr14_-_57960456 37.93 ENST00000534126.1
ENST00000422976.2
C14orf105
chromosome 14 open reading frame 105
chr9_-_123812542 36.87 ENST00000223642.1
C5
complement component 5
chr14_-_57960545 36.84 ENST00000526336.1
ENST00000216445.3
C14orf105
chromosome 14 open reading frame 105
chr5_+_176513895 36.50 ENST00000503708.1
ENST00000393648.2
ENST00000514472.1
ENST00000502906.1
ENST00000292410.3
ENST00000510911.1
FGFR4
fibroblast growth factor receptor 4
chr19_-_36304201 36.39 ENST00000301175.3
PRODH2
proline dehydrogenase (oxidase) 2
chr4_+_155484155 35.51 ENST00000509493.1
FGB
fibrinogen beta chain
chr4_+_155484103 35.08 ENST00000302068.4
FGB
fibrinogen beta chain
chr22_-_30970560 34.95 ENST00000402369.1
ENST00000406361.1
GAL3ST1
galactose-3-O-sulfotransferase 1
chr8_-_124749609 32.92 ENST00000262219.6
ENST00000419625.1
ANXA13
annexin A13
chr20_+_43029911 32.69 ENST00000443598.2
ENST00000316099.4
ENST00000415691.2
HNF4A
hepatocyte nuclear factor 4, alpha
chr17_+_73642315 30.08 ENST00000556126.2
SMIM6
small integral membrane protein 6
chr11_-_117695449 28.06 ENST00000292079.2
FXYD2
FXYD domain containing ion transport regulator 2
chr17_+_73642486 27.69 ENST00000579469.1
SMIM6
small integral membrane protein 6
chr10_+_5135981 27.60 ENST00000380554.3
AKR1C3
aldo-keto reductase family 1, member C3
chr5_+_176513868 27.56 ENST00000292408.4
FGFR4
fibroblast growth factor receptor 4
chr22_-_30968813 27.34 ENST00000443111.2
ENST00000443136.1
ENST00000426220.1
GAL3ST1
galactose-3-O-sulfotransferase 1
chr7_+_45927956 26.51 ENST00000275525.3
ENST00000457280.1
IGFBP1
insulin-like growth factor binding protein 1
chr20_+_42187682 22.98 ENST00000373092.3
ENST00000373077.1
SGK2
serum/glucocorticoid regulated kinase 2
chr22_-_30968839 22.76 ENST00000445645.1
ENST00000416358.1
ENST00000423371.1
ENST00000411821.1
ENST00000448604.1
GAL3ST1
galactose-3-O-sulfotransferase 1
chr16_+_81272287 22.51 ENST00000425577.2
ENST00000564552.1
BCMO1
beta-carotene 15,15'-monooxygenase 1
chr2_-_228244013 22.20 ENST00000304568.3
TM4SF20
transmembrane 4 L six family member 20
chr22_-_30970498 20.81 ENST00000431313.1
GAL3ST1
galactose-3-O-sulfotransferase 1
chr7_+_45928079 20.57 ENST00000468955.1
IGFBP1
insulin-like growth factor binding protein 1
chr8_-_95220775 19.83 ENST00000441892.2
ENST00000521491.1
ENST00000027335.3
CDH17
cadherin 17, LI cadherin (liver-intestine)
chr9_-_116861337 19.43 ENST00000374118.3
KIF12
kinesin family member 12
chr8_-_17752996 19.08 ENST00000381841.2
ENST00000427924.1
FGL1
fibrinogen-like 1
chr1_+_207277590 18.15 ENST00000367070.3
C4BPA
complement component 4 binding protein, alpha
chr16_+_20775024 17.46 ENST00000289416.5
ACSM3
acyl-CoA synthetase medium-chain family member 3
chr1_-_204183071 17.34 ENST00000308302.3
GOLT1A
golgi transport 1A
chr17_-_202579 17.04 ENST00000577079.1
ENST00000331302.7
ENST00000536489.2
RPH3AL
rabphilin 3A-like (without C2 domains)
chr17_+_4692230 16.79 ENST00000331264.7
GLTPD2
glycolipid transfer protein domain containing 2
chr7_-_27219849 16.79 ENST00000396344.4
HOXA10
homeobox A10
chr16_+_20775358 16.16 ENST00000440284.2
ACSM3
acyl-CoA synthetase medium-chain family member 3
chr16_-_57831914 15.69 ENST00000421376.2
KIFC3
kinesin family member C3
chr5_+_176514413 15.61 ENST00000513166.1
FGFR4
fibroblast growth factor receptor 4
chr20_+_42984330 15.60 ENST00000316673.4
ENST00000609795.1
ENST00000457232.1
ENST00000609262.1
HNF4A
hepatocyte nuclear factor 4, alpha
chr22_-_38506619 15.40 ENST00000332536.5
ENST00000381669.3
BAIAP2L2
BAI1-associated protein 2-like 2
chr20_+_42187608 14.63 ENST00000373100.1
SGK2
serum/glucocorticoid regulated kinase 2
chr5_-_138718973 13.90 ENST00000353963.3
ENST00000348729.3
SLC23A1
solute carrier family 23 (ascorbic acid transporter), member 1
chr3_+_183948161 13.42 ENST00000426955.2
VWA5B2
von Willebrand factor A domain containing 5B2
chr19_+_50016610 12.52 ENST00000596975.1
FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr14_+_21156915 11.65 ENST00000397990.4
ENST00000555597.1
ANG
RNASE4
angiogenin, ribonuclease, RNase A family, 5
ribonuclease, RNase A family, 4
chr1_+_18807424 11.11 ENST00000400664.1
KLHDC7A
kelch domain containing 7A
chr12_-_8693469 10.32 ENST00000545274.1
ENST00000446457.2
CLEC4E
C-type lectin domain family 4, member E
chr7_-_50633078 10.24 ENST00000444124.2
DDC
dopa decarboxylase (aromatic L-amino acid decarboxylase)
chr6_-_25874440 10.18 ENST00000361703.6
ENST00000397060.4
SLC17A3
solute carrier family 17 (organic anion transporter), member 3
chr12_+_20963632 9.90 ENST00000540853.1
ENST00000261196.2
SLCO1B3
solute carrier organic anion transporter family, member 1B3
chr2_-_47572207 9.70 ENST00000441997.1
AC073283.4
AC073283.4
chr2_-_99917639 9.57 ENST00000308528.4
LYG1
lysozyme G-like 1
chr11_+_560956 9.40 ENST00000397582.3
ENST00000344375.4
ENST00000397583.3
RASSF7
Ras association (RalGDS/AF-6) domain family (N-terminal) member 7
chr10_+_115312766 9.30 ENST00000351270.3
HABP2
hyaluronan binding protein 2
chr2_-_47572105 9.26 ENST00000419035.1
ENST00000448713.1
ENST00000450550.1
ENST00000413185.2
AC073283.4
AC073283.4
chr17_-_26733179 9.21 ENST00000440501.1
ENST00000321666.5
SLC46A1
solute carrier family 46 (folate transporter), member 1
chr16_-_57831676 9.15 ENST00000465878.2
ENST00000539578.1
ENST00000561524.1
KIFC3
kinesin family member C3
chr14_-_54425475 9.03 ENST00000559642.1
BMP4
bone morphogenetic protein 4
chr12_-_8693539 8.54 ENST00000299663.3
CLEC4E
C-type lectin domain family 4, member E
chr10_+_99344071 8.48 ENST00000370647.4
ENST00000370646.4
HOGA1
4-hydroxy-2-oxoglutarate aldolase 1
chr12_+_20963647 8.45 ENST00000381545.3
SLCO1B3
solute carrier organic anion transporter family, member 1B3
chr2_+_175199674 8.39 ENST00000394967.2
SP9
Sp9 transcription factor
chr19_+_54466179 8.39 ENST00000270458.2
CACNG8
calcium channel, voltage-dependent, gamma subunit 8
chr18_-_70931689 8.31 ENST00000581862.1
RP11-169F17.1
Protein LOC400655
chr6_+_31707725 8.29 ENST00000375755.3
ENST00000375742.3
ENST00000375750.3
ENST00000425703.1
ENST00000534153.4
ENST00000375703.3
ENST00000375740.3
MSH5
mutS homolog 5
chr2_+_133174147 8.20 ENST00000329321.3
GPR39
G protein-coupled receptor 39
chr11_-_64660916 8.02 ENST00000413053.1
MIR194-2
microRNA 194-2
chr20_+_35973080 7.88 ENST00000445403.1
SRC
v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
chr19_+_50016411 7.84 ENST00000426395.3
ENST00000600273.1
ENST00000599988.1
FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr17_-_26733604 7.46 ENST00000584426.1
ENST00000584995.1
SLC46A1
solute carrier family 46 (folate transporter), member 1
chr11_-_65149422 7.39 ENST00000526432.1
ENST00000527174.1
SLC25A45
solute carrier family 25, member 45
chr1_+_207277632 7.27 ENST00000421786.1
C4BPA
complement component 4 binding protein, alpha
chr3_-_137834436 7.08 ENST00000327532.2
ENST00000467030.1
DZIP1L
DAZ interacting zinc finger protein 1-like
chr16_+_21244986 6.95 ENST00000311620.5
ANKS4B
ankyrin repeat and sterile alpha motif domain containing 4B
chr4_-_987217 6.53 ENST00000361661.2
ENST00000398516.2
SLC26A1
solute carrier family 26 (anion exchanger), member 1
chr16_-_57832004 6.44 ENST00000562503.1
KIFC3
kinesin family member C3
chr14_-_65409502 6.21 ENST00000389614.5
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr7_-_47579188 5.99 ENST00000398879.1
ENST00000355730.3
ENST00000442536.2
ENST00000458317.2
TNS3
tensin 3
chr2_-_87248975 5.94 ENST00000409310.2
ENST00000355705.3
PLGLB1
plasminogen-like B1
chr7_-_155601766 5.92 ENST00000430104.1
SHH
sonic hedgehog
chr6_-_127840453 5.85 ENST00000556132.1
SOGA3
SOGA family member 3
chr19_-_57678811 5.59 ENST00000554048.2
DUXA
double homeobox A
chr8_+_21911054 5.52 ENST00000519850.1
ENST00000381470.3
DMTN
dematin actin binding protein
chr6_+_126221034 5.46 ENST00000433571.1
NCOA7
nuclear receptor coactivator 7
chr1_+_55505184 5.35 ENST00000302118.5
PCSK9
proprotein convertase subtilisin/kexin type 9
chr10_+_115312825 5.33 ENST00000537906.1
ENST00000541666.1
HABP2
hyaluronan binding protein 2
chr6_-_127840021 5.07 ENST00000465909.2
SOGA3
SOGA family member 3
chr6_-_127840336 5.01 ENST00000525778.1
SOGA3
SOGA family member 3
chr14_+_39703112 4.89 ENST00000555143.1
ENST00000280082.3
MIA2
melanoma inhibitory activity 2
chr6_+_161123270 4.83 ENST00000366924.2
ENST00000308192.9
ENST00000418964.1
PLG
plasminogen
chr17_+_79953310 4.74 ENST00000582355.2
ASPSCR1
alveolar soft part sarcoma chromosome region, candidate 1
chr4_-_110723194 4.57 ENST00000394635.3
CFI
complement factor I
chr11_+_46740730 4.53 ENST00000311907.5
ENST00000530231.1
ENST00000442468.1
F2
coagulation factor II (thrombin)
chr2_+_38177575 4.47 ENST00000407257.1
ENST00000417700.2
ENST00000234195.3
ENST00000442857.1
RMDN2
regulator of microtubule dynamics 2
chr1_-_114430169 4.42 ENST00000393316.3
BCL2L15
BCL2-like 15
chr12_+_100867694 4.39 ENST00000392986.3
ENST00000549996.1
NR1H4
nuclear receptor subfamily 1, group H, member 4
chr16_-_66952779 4.26 ENST00000570262.1
ENST00000394055.3
ENST00000299752.4
CDH16
cadherin 16, KSP-cadherin
chr7_+_141695633 4.16 ENST00000549489.2
MGAM
maltase-glucoamylase (alpha-glucosidase)
chr9_-_94712434 4.08 ENST00000375708.3
ROR2
receptor tyrosine kinase-like orphan receptor 2
chr14_-_65409438 4.06 ENST00000557049.1
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr2_-_55920952 3.93 ENST00000447944.2
PNPT1
polyribonucleotide nucleotidyltransferase 1
chr4_-_110723335 3.91 ENST00000394634.2
CFI
complement factor I
chr4_-_987164 3.91 ENST00000398520.2
SLC26A1
solute carrier family 26 (anion exchanger), member 1
chr9_-_98079965 3.83 ENST00000289081.3
FANCC
Fanconi anemia, complementation group C
chr7_+_130126012 3.82 ENST00000341441.5
MEST
mesoderm specific transcript
chr12_+_100867486 3.82 ENST00000548884.1
NR1H4
nuclear receptor subfamily 1, group H, member 4
chr20_+_62371206 3.68 ENST00000266077.2
SLC2A4RG
SLC2A4 regulator
chr7_+_141695671 3.59 ENST00000497673.1
ENST00000475668.2
MGAM
maltase-glucoamylase (alpha-glucosidase)
chr6_-_127840048 3.54 ENST00000467753.1
SOGA3
SOGA family member 3
chr1_+_48688357 3.52 ENST00000533824.1
ENST00000438567.2
ENST00000236495.5
ENST00000420136.2
SLC5A9
solute carrier family 5 (sodium/sugar cotransporter), member 9
chr22_+_31003190 3.49 ENST00000407817.3
TCN2
transcobalamin II
chr4_+_3443614 3.48 ENST00000382774.3
ENST00000511533.1
HGFAC
HGF activator
chr16_-_66952742 3.44 ENST00000565235.2
ENST00000568632.1
ENST00000565796.1
CDH16
cadherin 16, KSP-cadherin
chr3_-_157221380 3.44 ENST00000468233.1
VEPH1
ventricular zone expressed PH domain-containing 1
chr11_+_64323156 3.42 ENST00000377585.3
SLC22A11
solute carrier family 22 (organic anion/urate transporter), member 11
chr7_-_27219632 3.24 ENST00000470747.4
RP1-170O19.20
Uncharacterized protein
chr11_+_64323098 3.22 ENST00000301891.4
SLC22A11
solute carrier family 22 (organic anion/urate transporter), member 11
chr2_+_27719697 3.21 ENST00000264717.2
ENST00000424318.2
GCKR
glucokinase (hexokinase 4) regulator
chr16_-_420514 3.20 ENST00000199706.8
MRPL28
mitochondrial ribosomal protein L28
chr22_+_31003133 3.19 ENST00000405742.3
TCN2
transcobalamin II
chr7_+_130126165 3.19 ENST00000427521.1
ENST00000416162.2
ENST00000378576.4
MEST
mesoderm specific transcript
chr12_+_100897130 3.17 ENST00000551379.1
ENST00000188403.7
ENST00000551184.1
NR1H4
nuclear receptor subfamily 1, group H, member 4
chr6_-_161085291 3.16 ENST00000316300.5
LPA
lipoprotein, Lp(a)
chr10_-_128359074 3.08 ENST00000544758.1
C10orf90
chromosome 10 open reading frame 90
chr10_-_52645416 3.04 ENST00000374001.2
ENST00000373997.3
ENST00000373995.3
ENST00000282641.2
ENST00000395495.1
ENST00000414883.1
A1CF
APOBEC1 complementation factor
chr22_+_31002779 2.98 ENST00000215838.3
TCN2
transcobalamin II
chr3_-_157221128 2.98 ENST00000392833.2
ENST00000362010.2
VEPH1
ventricular zone expressed PH domain-containing 1
chr22_-_32651326 2.96 ENST00000266086.4
SLC5A4
solute carrier family 5 (glucose activated ion channel), member 4
chr1_+_207262881 2.81 ENST00000451804.2
C4BPB
complement component 4 binding protein, beta
chr19_-_11639910 2.77 ENST00000588998.1
ENST00000586149.1
ECSIT
ECSIT signalling integrator
chr21_-_19775973 2.72 ENST00000284885.3
TMPRSS15
transmembrane protease, serine 15
chr3_-_157221357 2.64 ENST00000494677.1
VEPH1
ventricular zone expressed PH domain-containing 1
chr10_-_72648541 2.58 ENST00000299299.3
PCBD1
pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
chr17_+_68071389 2.57 ENST00000283936.1
ENST00000392671.1
KCNJ16
potassium inwardly-rectifying channel, subfamily J, member 16
chr20_-_7921090 2.49 ENST00000378789.3
HAO1
hydroxyacid oxidase (glycolate oxidase) 1
chr7_-_47578840 2.49 ENST00000450444.1
TNS3
tensin 3
chr6_+_25754927 2.48 ENST00000377905.4
ENST00000439485.2
SLC17A4
solute carrier family 17, member 4
chr6_-_52628271 2.47 ENST00000493422.1
GSTA2
glutathione S-transferase alpha 2
chr12_+_21284118 2.42 ENST00000256958.2
SLCO1B1
solute carrier organic anion transporter family, member 1B1
chr4_+_124571409 2.39 ENST00000514823.1
ENST00000511919.1
ENST00000508111.1
RP11-93L9.1
long intergenic non-protein coding RNA 1091
chr5_-_77844974 2.38 ENST00000515007.2
LHFPL2
lipoma HMGIC fusion partner-like 2
chr21_-_35340759 2.36 ENST00000607953.1
AP000569.9
AP000569.9
chrX_+_120181457 2.33 ENST00000328078.1
GLUD2
glutamate dehydrogenase 2
chr12_+_100867733 2.33 ENST00000546380.1
NR1H4
nuclear receptor subfamily 1, group H, member 4
chr8_-_108510224 2.32 ENST00000517746.1
ENST00000297450.3
ANGPT1
angiopoietin 1
chr6_+_54173227 2.30 ENST00000259782.4
ENST00000370864.3
TINAG
tubulointerstitial nephritis antigen
chr6_-_116833500 2.30 ENST00000356128.4
TRAPPC3L
trafficking protein particle complex 3-like
chr3_-_107596910 2.29 ENST00000464359.2
ENST00000464823.1
ENST00000466155.1
ENST00000473528.2
ENST00000608306.1
ENST00000488852.1
ENST00000608137.1
ENST00000608307.1
ENST00000609429.1
ENST00000601385.1
ENST00000475362.1
ENST00000600240.1
ENST00000600749.1
LINC00635
long intergenic non-protein coding RNA 635
chr4_+_74269956 2.29 ENST00000295897.4
ENST00000415165.2
ENST00000503124.1
ENST00000509063.1
ENST00000401494.3
ALB
albumin
chr11_+_20620946 2.25 ENST00000525748.1
SLC6A5
solute carrier family 6 (neurotransmitter transporter), member 5
chr9_+_140125385 2.25 ENST00000361134.2
SLC34A3
solute carrier family 34 (type II sodium/phosphate contransporter), member 3
chr5_+_175976324 2.18 ENST00000261944.5
CDHR2
cadherin-related family member 2
chr1_+_66999799 2.16 ENST00000371035.3
ENST00000371036.3
ENST00000371037.4
SGIP1
SH3-domain GRB2-like (endophilin) interacting protein 1
chr19_-_11639931 2.12 ENST00000592312.1
ENST00000590480.1
ENST00000585318.1
ENST00000252440.7
ENST00000417981.2
ENST00000270517.7
ECSIT
ECSIT signalling integrator
chr9_+_130860810 2.12 ENST00000433501.1
SLC25A25
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25
chr3_-_192445289 2.07 ENST00000430714.1
ENST00000418610.1
ENST00000448795.1
ENST00000445105.2
FGF12
fibroblast growth factor 12
chr14_+_39703084 2.00 ENST00000553728.1
RP11-407N17.3
cTAGE family member 5 isoform 4
chr12_-_102874416 1.99 ENST00000392904.1
ENST00000337514.6
IGF1
insulin-like growth factor 1 (somatomedin C)
chr16_+_22524379 1.98 ENST00000536620.1
NPIPB5
nuclear pore complex interacting protein family, member B5
chr17_+_68071458 1.84 ENST00000589377.1
KCNJ16
potassium inwardly-rectifying channel, subfamily J, member 16
chr4_+_14113592 1.78 ENST00000502759.1
ENST00000511200.1
ENST00000512754.1
ENST00000506739.1
LINC01085
long intergenic non-protein coding RNA 1085
chr17_-_36904437 1.76 ENST00000585100.1
ENST00000360797.2
ENST00000578109.1
ENST00000579882.1
PCGF2
polycomb group ring finger 2
chr1_+_84767289 1.73 ENST00000394834.3
ENST00000370669.1
SAMD13
sterile alpha motif domain containing 13
chr22_+_31002990 1.67 ENST00000423350.1
TCN2
transcobalamin II
chr9_+_130860583 1.66 ENST00000373064.5
SLC25A25
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25
chrX_-_124097620 1.63 ENST00000371130.3
ENST00000422452.2
TENM1
teneurin transmembrane protein 1
chr17_+_1646130 1.62 ENST00000453066.1
ENST00000324015.3
ENST00000450523.2
ENST00000453723.1
ENST00000382061.4
SERPINF2
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
chr3_-_169587621 1.61 ENST00000523069.1
ENST00000316428.5
ENST00000264676.5
LRRC31
leucine rich repeat containing 31
chr19_-_43099070 1.57 ENST00000244336.5
CEACAM8
carcinoembryonic antigen-related cell adhesion molecule 8
chr7_+_120629653 1.50 ENST00000450913.2
ENST00000340646.5
CPED1
cadherin-like and PC-esterase domain containing 1
chr2_-_158300556 1.48 ENST00000264192.3
CYTIP
cytohesin 1 interacting protein
chr3_-_49466686 1.47 ENST00000273598.3
ENST00000436744.2
NICN1
nicolin 1
chr19_+_41305085 1.44 ENST00000303961.4
EGLN2
egl-9 family hypoxia-inducible factor 2
chr15_+_58430567 1.40 ENST00000536493.1
AQP9
aquaporin 9
chr4_-_70518941 1.40 ENST00000286604.4
ENST00000505512.1
ENST00000514019.1
UGT2A1
UGT2A1
UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus
UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus
chr8_+_55047763 1.39 ENST00000260102.4
ENST00000519831.1
MRPL15
mitochondrial ribosomal protein L15
chr3_-_161089289 1.33 ENST00000497137.1
SPTSSB
serine palmitoyltransferase, small subunit B
chr15_+_58430368 1.32 ENST00000558772.1
ENST00000219919.4
AQP9
aquaporin 9
chr6_+_167704838 1.31 ENST00000366829.2
UNC93A
unc-93 homolog A (C. elegans)
chr16_-_20587599 1.28 ENST00000566384.1
ENST00000565232.1
ENST00000567001.1
ENST00000565322.1
ENST00000569344.1
ENST00000329697.6
ENST00000414188.2
ENST00000568882.1
ACSM2B
acyl-CoA synthetase medium-chain family member 2B
chrX_+_36254051 1.20 ENST00000378657.4
CXorf30
chromosome X open reading frame 30
chr17_+_48823975 1.20 ENST00000513969.1
ENST00000503728.1
LUC7L3
LUC7-like 3 (S. cerevisiae)
chr9_-_215744 1.19 ENST00000382387.2
C9orf66
chromosome 9 open reading frame 66
chr16_-_55909211 1.15 ENST00000520435.1
CES5A
carboxylesterase 5A
chr1_-_159684371 1.15 ENST00000255030.5
ENST00000437342.1
ENST00000368112.1
ENST00000368111.1
ENST00000368110.1
ENST00000343919.2
CRP
C-reactive protein, pentraxin-related
chr12_-_54653313 1.15 ENST00000550411.1
ENST00000439541.2
CBX5
chromobox homolog 5
chr1_-_197036364 1.11 ENST00000367412.1
F13B
coagulation factor XIII, B polypeptide
chr4_+_141264597 1.10 ENST00000338517.4
ENST00000394203.3
ENST00000506322.1
SCOC
short coiled-coil protein
chr1_+_17906970 1.09 ENST00000375415.1
ARHGEF10L
Rho guanine nucleotide exchange factor (GEF) 10-like
chr17_+_48823896 1.02 ENST00000511974.1
LUC7L3
LUC7-like 3 (S. cerevisiae)
chr16_-_55909255 1.00 ENST00000290567.9
CES5A
carboxylesterase 5A
chr16_-_55909272 0.99 ENST00000319165.9
CES5A
carboxylesterase 5A
chr10_-_38146510 0.97 ENST00000395867.3
ZNF248
zinc finger protein 248
chr14_+_24590560 0.96 ENST00000558325.1
RP11-468E2.6
RP11-468E2.6
chr6_+_54172653 0.96 ENST00000370869.3
TINAG
tubulointerstitial nephritis antigen
chr13_+_96085847 0.95 ENST00000376873.3
CLDN10
claudin 10
chr10_-_101690650 0.93 ENST00000543621.1
DNMBP
dynamin binding protein
chr1_+_207262578 0.92 ENST00000243611.5
ENST00000367076.3
C4BPB
complement component 4 binding protein, beta
chr9_+_140125209 0.92 ENST00000538474.1
SLC34A3
solute carrier family 34 (type II sodium/phosphate contransporter), member 3
chr12_-_102874102 0.89 ENST00000392905.2
IGF1
insulin-like growth factor 1 (somatomedin C)

Network of associatons between targets according to the STRING database.

First level regulatory network of HNF1A_HNF1B

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
14.0 41.9 GO:0016999 antibiotic metabolic process(GO:0016999)
13.3 79.7 GO:1903412 response to bile acid(GO:1903412)
9.2 27.6 GO:2000224 sesquiterpenoid metabolic process(GO:0006714) sesquiterpenoid catabolic process(GO:0016107) farnesol metabolic process(GO:0016487) farnesol catabolic process(GO:0016488) regulation of testosterone biosynthetic process(GO:2000224)
8.1 105.9 GO:0019375 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
7.9 110.5 GO:0043152 induction of bacterial agglutination(GO:0043152)
6.8 20.4 GO:0002416 IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor(GO:0002416)
6.1 36.9 GO:0010760 negative regulation of macrophage chemotaxis(GO:0010760)
5.2 36.4 GO:0010133 proline catabolic process to glutamate(GO:0010133)
4.8 48.3 GO:2000189 positive regulation of cholesterol homeostasis(GO:2000189)
4.6 13.9 GO:0015882 L-ascorbic acid transport(GO:0015882) transepithelial L-ascorbic acid transport(GO:0070904)
4.3 51.4 GO:0034392 negative regulation of smooth muscle cell apoptotic process(GO:0034392)
4.2 8.5 GO:0019470 4-hydroxyproline catabolic process(GO:0019470)
4.0 19.8 GO:0002314 germinal center B cell differentiation(GO:0002314)
3.4 13.7 GO:2000213 nitrogen catabolite regulation of transcription from RNA polymerase II promoter(GO:0001079) nitrogen catabolite activation of transcription from RNA polymerase II promoter(GO:0001080) regulation of urea metabolic process(GO:0034255) intracellular bile acid receptor signaling pathway(GO:0038185) interleukin-17 secretion(GO:0072615) nitrogen catabolite regulation of transcription(GO:0090293) nitrogen catabolite activation of transcription(GO:0090294) regulation of nitrogen cycle metabolic process(GO:1903314) positive regulation of glutamate metabolic process(GO:2000213) regulation of ammonia assimilation cycle(GO:2001248) positive regulation of ammonia assimilation cycle(GO:2001250)
3.4 10.2 GO:0052314 phytoalexin metabolic process(GO:0052314)
3.1 31.3 GO:0045218 zonula adherens maintenance(GO:0045218)
3.1 30.7 GO:0030450 regulation of complement activation, classical pathway(GO:0030450) negative regulation of complement activation, classical pathway(GO:0045959)
2.8 16.7 GO:0051958 methotrexate transport(GO:0051958)
2.0 5.9 GO:0060738 intein-mediated protein splicing(GO:0016539) protein splicing(GO:0030908) positive regulation of immature T cell proliferation in thymus(GO:0033092) right lung development(GO:0060458) primary prostatic bud elongation(GO:0060516) epithelial-mesenchymal signaling involved in prostate gland development(GO:0060738)
2.0 7.9 GO:0071393 cellular response to progesterone stimulus(GO:0071393)
1.9 11.7 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
1.8 9.0 GO:2000005 apoptotic process involved in endocardial cushion morphogenesis(GO:0003277) intermediate mesoderm morphogenesis(GO:0048390) intermediate mesoderm formation(GO:0048391) intermediate mesodermal cell differentiation(GO:0048392) regulation of cardiac muscle fiber development(GO:0055018) positive regulation of cardiac muscle fiber development(GO:0055020) bud dilation involved in lung branching(GO:0060503) BMP signaling pathway involved in ureter morphogenesis(GO:0061149) renal system segmentation(GO:0061150) BMP signaling pathway involved in renal system segmentation(GO:0061151) pulmonary artery endothelial tube morphogenesis(GO:0061155) regulation of transcription from RNA polymerase II promoter involved in mesonephros development(GO:0061216) BMP signaling pathway involved in nephric duct formation(GO:0071893) negative regulation of branch elongation involved in ureteric bud branching(GO:0072096) negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway(GO:0072097) anterior/posterior pattern specification involved in ureteric bud development(GO:0072099) specification of ureteric bud anterior/posterior symmetry(GO:0072100) specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway(GO:0072101) ureter epithelial cell differentiation(GO:0072192) negative regulation of mesenchymal cell proliferation involved in ureter development(GO:0072200) positive regulation of cell proliferation involved in outflow tract morphogenesis(GO:1901964) cardiac jelly development(GO:1905072) regulation of metanephric S-shaped body morphogenesis(GO:2000004) negative regulation of metanephric S-shaped body morphogenesis(GO:2000005) regulation of metanephric comma-shaped body morphogenesis(GO:2000006) negative regulation of metanephric comma-shaped body morphogenesis(GO:2000007)
1.8 5.3 GO:2000646 positive regulation of receptor catabolic process(GO:2000646)
1.7 7.0 GO:1904106 protein localization to microvillus(GO:1904106)
1.6 4.8 GO:0051919 positive regulation of fibrinolysis(GO:0051919)
1.5 4.5 GO:1900738 positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738)
1.4 28.1 GO:1990573 potassium ion import across plasma membrane(GO:1990573)
1.4 47.1 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
1.4 14.9 GO:0015747 urate transport(GO:0015747)
1.3 3.9 GO:2000627 rRNA import into mitochondrion(GO:0035928) regulation of miRNA catabolic process(GO:2000625) positive regulation of miRNA catabolic process(GO:2000627)
1.2 9.6 GO:0000270 peptidoglycan metabolic process(GO:0000270) peptidoglycan catabolic process(GO:0009253)
1.2 7.1 GO:0044245 polysaccharide digestion(GO:0044245)
1.0 10.4 GO:0034036 purine ribonucleoside bisphosphate biosynthetic process(GO:0034036) 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process(GO:0050428)
0.9 7.4 GO:0000066 mitochondrial ornithine transport(GO:0000066)
0.9 11.3 GO:0015889 cobalt ion transport(GO:0006824) cobalamin transport(GO:0015889)
0.8 2.5 GO:0009441 glycolate metabolic process(GO:0009441)
0.8 2.3 GO:0044179 hemolysis by symbiont of host erythrocytes(GO:0019836) hemolysis in other organism(GO:0044179) hemolysis in other organism involved in symbiotic interaction(GO:0052331)
0.8 8.3 GO:0051026 chiasma assembly(GO:0051026)
0.7 2.2 GO:0090675 intermicrovillar adhesion(GO:0090675)
0.7 4.1 GO:0030538 embryonic genitalia morphogenesis(GO:0030538)
0.6 20.5 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.6 15.4 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.6 5.5 GO:0070560 protein secretion by platelet(GO:0070560)
0.5 2.7 GO:0015722 canalicular bile acid transport(GO:0015722)
0.5 3.2 GO:1903300 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.5 2.3 GO:0048014 Tie signaling pathway(GO:0048014)
0.5 16.8 GO:0060065 uterus development(GO:0060065)
0.4 1.6 GO:0002034 regulation of blood vessel size by renin-angiotensin(GO:0002034) renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure(GO:0003072)
0.4 3.2 GO:0034374 low-density lipoprotein particle remodeling(GO:0034374)
0.3 32.1 GO:0042632 cholesterol homeostasis(GO:0042632) sterol homeostasis(GO:0055092)
0.3 3.8 GO:0016554 cytidine to uridine editing(GO:0016554)
0.3 17.0 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.3 3.2 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.3 8.4 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.3 5.5 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.3 2.1 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.3 36.5 GO:0032411 positive regulation of transporter activity(GO:0032411)
0.2 2.2 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.2 3.8 GO:0015866 ADP transport(GO:0015866)
0.2 2.6 GO:0046146 tetrahydrobiopterin biosynthetic process(GO:0006729) tetrahydrobiopterin metabolic process(GO:0046146)
0.2 2.3 GO:0060012 synaptic transmission, glycinergic(GO:0060012)
0.2 2.3 GO:0006538 glutamate catabolic process(GO:0006538)
0.2 8.2 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.2 1.6 GO:0040032 post-embryonic body morphogenesis(GO:0040032)
0.2 1.3 GO:1904220 regulation of serine C-palmitoyltransferase activity(GO:1904220)
0.2 8.5 GO:0048286 lung alveolus development(GO:0048286)
0.2 18.9 GO:0002292 T cell differentiation involved in immune response(GO:0002292)
0.1 0.6 GO:0070843 misfolded protein transport(GO:0070843) polyubiquitinated protein transport(GO:0070844) polyubiquitinated misfolded protein transport(GO:0070845) Hsp90 deacetylation(GO:0070846)
0.1 0.7 GO:0090080 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway(GO:0090080)
0.1 4.7 GO:0010827 regulation of glucose transport(GO:0010827) regulation of glucose import(GO:0046324)
0.1 0.7 GO:0015860 purine nucleoside transmembrane transport(GO:0015860)
0.1 0.4 GO:0070175 positive regulation of enamel mineralization(GO:0070175)
0.1 1.1 GO:0008228 opsonization(GO:0008228)
0.1 4.9 GO:1904659 hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659)
0.1 0.4 GO:0006447 regulation of translational initiation by iron(GO:0006447)
0.1 1.4 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.1 9.3 GO:0006958 complement activation, classical pathway(GO:0006958)
0.1 14.6 GO:0098869 cellular oxidant detoxification(GO:0098869)
0.1 2.2 GO:0035435 phosphate ion transmembrane transport(GO:0035435)
0.1 1.4 GO:0007608 sensory perception of smell(GO:0007608)
0.1 1.1 GO:0061635 regulation of protein complex stability(GO:0061635)
0.1 0.7 GO:0055090 acylglycerol homeostasis(GO:0055090) triglyceride homeostasis(GO:0070328)
0.1 1.1 GO:1901687 glutathione derivative metabolic process(GO:1901685) glutathione derivative biosynthetic process(GO:1901687)
0.0 4.9 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0 0.5 GO:0055059 asymmetric neuroblast division(GO:0055059)
0.0 0.5 GO:0031284 positive regulation of guanylate cyclase activity(GO:0031284)
0.0 5.3 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.0 8.4 GO:0035113 embryonic limb morphogenesis(GO:0030326) embryonic appendage morphogenesis(GO:0035113)
0.0 18.1 GO:0007018 microtubule-based movement(GO:0007018)
0.0 0.5 GO:0090004 positive regulation of establishment of protein localization to plasma membrane(GO:0090004)
0.0 1.6 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.0 2.2 GO:0006376 mRNA splice site selection(GO:0006376)
0.0 0.5 GO:0035176 social behavior(GO:0035176) intraspecies interaction between organisms(GO:0051703)
0.0 9.9 GO:0070507 regulation of microtubule cytoskeleton organization(GO:0070507)
0.0 6.6 GO:0007498 mesoderm development(GO:0007498)
0.0 0.3 GO:0097338 response to clozapine(GO:0097338)
0.0 0.8 GO:0006835 dicarboxylic acid transport(GO:0006835)
0.0 0.5 GO:0015939 pantothenate metabolic process(GO:0015939)
0.0 13.1 GO:0010506 regulation of autophagy(GO:0010506)
0.0 0.9 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.0 7.1 GO:0060271 cilium morphogenesis(GO:0060271)
0.0 0.6 GO:0043968 histone H2A acetylation(GO:0043968)
0.0 1.8 GO:0070301 cellular response to hydrogen peroxide(GO:0070301)
0.0 2.3 GO:0007599 blood coagulation(GO:0007596) hemostasis(GO:0007599)
0.0 0.3 GO:1902358 sulfate transmembrane transport(GO:1902358)
0.0 2.4 GO:0002576 platelet degranulation(GO:0002576)
0.0 0.2 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.0 0.2 GO:0007586 digestion(GO:0007586)
0.0 0.2 GO:0006677 glycosylceramide metabolic process(GO:0006677)
0.0 0.3 GO:0019432 triglyceride biosynthetic process(GO:0019432)
0.0 2.4 GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway(GO:0007188)
0.0 5.1 GO:0006898 receptor-mediated endocytosis(GO:0006898)
0.0 0.4 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.0 1.2 GO:0019233 sensory perception of pain(GO:0019233)
0.0 4.9 GO:0045861 negative regulation of proteolysis(GO:0045861)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
9.4 132.0 GO:0005577 fibrinogen complex(GO:0005577)
4.6 36.9 GO:0005579 membrane attack complex(GO:0005579)
3.3 39.9 GO:0046581 intercellular canaliculus(GO:0046581)
2.6 46.7 GO:0031089 platelet dense granule lumen(GO:0031089)
1.8 5.3 GO:1990666 PCSK9-LDLR complex(GO:1990666)
1.7 11.7 GO:0032311 angiogenin-PRI complex(GO:0032311)
1.3 3.8 GO:0030895 apolipoprotein B mRNA editing enzyme complex(GO:0030895)
1.3 31.3 GO:0005915 zonula adherens(GO:0005915)
1.1 28.1 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.9 15.4 GO:0071439 clathrin complex(GO:0071439)
0.7 4.8 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.7 4.6 GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867)
0.5 8.3 GO:0032300 mismatch repair complex(GO:0032300)
0.4 2.2 GO:0089717 spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
0.4 4.1 GO:0030669 clathrin-coated endocytic vesicle membrane(GO:0030669)
0.3 3.8 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.3 3.9 GO:0042788 polysomal ribosome(GO:0042788)
0.3 13.7 GO:0005719 nuclear euchromatin(GO:0005719)
0.2 5.5 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.2 13.9 GO:0009925 basal plasma membrane(GO:0009925)
0.2 30.7 GO:0044216 other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217)
0.2 18.7 GO:0031526 brush border membrane(GO:0031526)
0.2 18.1 GO:0005871 kinesin complex(GO:0005871)
0.2 8.4 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.2 4.7 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.2 1.8 GO:0001739 sex chromatin(GO:0001739)
0.2 4.9 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.1 79.3 GO:0030133 transport vesicle(GO:0030133)
0.1 2.3 GO:0030008 TRAPP complex(GO:0030008)
0.1 48.5 GO:0016323 basolateral plasma membrane(GO:0016323)
0.1 2.2 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.1 7.9 GO:0002102 podosome(GO:0002102)
0.1 2.4 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.1 1.3 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.1 11.1 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 105.6 GO:0000139 Golgi membrane(GO:0000139)
0.1 40.3 GO:0005759 mitochondrial matrix(GO:0005759)
0.1 9.3 GO:0070821 tertiary granule membrane(GO:0070821)
0.1 58.0 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.1 2.2 GO:0071004 U2-type prespliceosome(GO:0071004)
0.1 1.1 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.1 0.8 GO:0031528 microvillus membrane(GO:0031528)
0.1 29.4 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 11.3 GO:0043202 lysosomal lumen(GO:0043202)
0.1 0.6 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.1 3.2 GO:0034358 plasma lipoprotein particle(GO:0034358) lipoprotein particle(GO:1990777)
0.1 7.6 GO:0036064 ciliary basal body(GO:0036064)
0.1 1.9 GO:0005903 brush border(GO:0005903)
0.0 3.1 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 2.8 GO:0005902 microvillus(GO:0005902)
0.0 3.3 GO:0005604 basement membrane(GO:0005604)
0.0 0.7 GO:0031143 pseudopodium(GO:0031143)
0.0 21.7 GO:0005925 focal adhesion(GO:0005925)
0.0 16.1 GO:0005667 transcription factor complex(GO:0005667)
0.0 1.6 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.9 GO:0005795 Golgi stack(GO:0005795)
0.0 0.6 GO:0005771 multivesicular body(GO:0005771)
0.0 5.9 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 27.6 GO:0005615 extracellular space(GO:0005615)
0.0 7.5 GO:0005815 microtubule organizing center(GO:0005815)
0.0 0.3 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 26.3 GO:0070062 extracellular exosome(GO:0070062)
0.0 1.6 GO:0016363 nuclear matrix(GO:0016363)
0.0 47.4 GO:0005654 nucleoplasm(GO:0005654)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
9.4 46.8 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
9.2 27.6 GO:0047017 geranylgeranyl reductase activity(GO:0045550) prostaglandin-F synthase activity(GO:0047017)
9.1 36.4 GO:0004657 proline dehydrogenase activity(GO:0004657)
8.8 105.9 GO:0001733 galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
6.6 79.7 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
6.6 19.8 GO:0015322 proton-dependent oligopeptide secondary active transmembrane transporter activity(GO:0005427) secondary active oligopeptide transmembrane transporter activity(GO:0015322)
4.6 13.9 GO:0015229 L-ascorbate:sodium symporter activity(GO:0008520) L-ascorbic acid transporter activity(GO:0015229) sodium-dependent L-ascorbate transmembrane transporter activity(GO:0070890)
4.1 20.4 GO:0019770 IgG receptor activity(GO:0019770)
3.4 13.7 GO:1902122 chenodeoxycholic acid binding(GO:1902122)
3.4 47.1 GO:0031995 insulin-like growth factor II binding(GO:0031995)
3.2 35.6 GO:0004321 fatty-acyl-CoA synthase activity(GO:0004321)
2.8 16.7 GO:0015350 methotrexate transporter activity(GO:0015350)
2.2 41.1 GO:0043225 anion transmembrane-transporting ATPase activity(GO:0043225)
1.7 11.7 GO:0004522 ribonuclease A activity(GO:0004522)
1.6 4.8 GO:1904854 proteasome core complex binding(GO:1904854)
1.4 17.0 GO:0030274 LIM domain binding(GO:0030274)
1.3 37.6 GO:0017081 chloride channel regulator activity(GO:0017081)
1.3 5.3 GO:0070326 very-low-density lipoprotein particle binding(GO:0034189) very-low-density lipoprotein particle receptor binding(GO:0070326)
1.3 28.1 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
1.3 14.3 GO:1901702 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
1.2 8.5 GO:0016833 oxo-acid-lyase activity(GO:0016833)
1.1 7.4 GO:0000064 L-ornithine transmembrane transporter activity(GO:0000064)
1.0 7.3 GO:0016160 amylase activity(GO:0016160)
1.0 31.3 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.9 2.7 GO:0005275 amine transmembrane transporter activity(GO:0005275)
0.9 4.4 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.9 11.3 GO:0031419 cobalamin binding(GO:0031419)
0.9 2.6 GO:0016899 oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)
0.9 2.6 GO:0008124 phenylalanine 4-monooxygenase activity(GO:0004505) 4-alpha-hydroxytetrahydrobiopterin dehydratase activity(GO:0008124)
0.8 36.1 GO:0008009 chemokine activity(GO:0008009)
0.8 9.6 GO:0003796 lysozyme activity(GO:0003796)
0.8 46.5 GO:0005504 fatty acid binding(GO:0005504)
0.7 18.6 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.7 5.9 GO:0043237 laminin-1 binding(GO:0043237)
0.7 7.9 GO:0071253 connexin binding(GO:0071253)
0.6 9.0 GO:0070700 BMP receptor binding(GO:0070700)
0.6 3.2 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.6 2.3 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
0.6 2.3 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.6 3.9 GO:0034046 poly(G) binding(GO:0034046)
0.5 10.4 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.5 4.9 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.5 4.1 GO:1904929 coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway(GO:1904929)
0.4 70.6 GO:0051087 chaperone binding(GO:0051087)
0.4 8.3 GO:0030983 mismatched DNA binding(GO:0030983)
0.3 10.3 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.3 4.5 GO:0070053 thrombospondin receptor activity(GO:0070053)
0.3 5.3 GO:0005436 sodium:phosphate symporter activity(GO:0005436)
0.3 4.6 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.3 3.8 GO:0015217 ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)
0.3 0.8 GO:0015361 low-affinity sodium:dicarboxylate symporter activity(GO:0015361)
0.2 1.1 GO:0033265 choline binding(GO:0033265)
0.2 0.7 GO:0051185 coenzyme transporter activity(GO:0051185)
0.2 25.1 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.2 14.8 GO:0005044 scavenger receptor activity(GO:0005044)
0.2 1.3 GO:0016454 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.2 18.1 GO:0003777 microtubule motor activity(GO:0003777)
0.1 1.8 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.1 10.2 GO:0016831 carboxy-lyase activity(GO:0016831)
0.1 0.7 GO:0008422 beta-glucosidase activity(GO:0008422)
0.1 0.3 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271)
0.1 8.4 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.1 1.6 GO:0051430 corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.1 1.4 GO:0019826 oxygen sensor activity(GO:0019826)
0.1 1.8 GO:0034185 apolipoprotein binding(GO:0034185)
0.1 18.6 GO:0042826 histone deacetylase binding(GO:0042826)
0.1 5.5 GO:0030507 spectrin binding(GO:0030507)
0.1 0.5 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.1 0.4 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.1 0.8 GO:0034235 GPI anchor binding(GO:0034235) metallodipeptidase activity(GO:0070573)
0.1 6.2 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.1 0.4 GO:0030345 extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345)
0.1 24.7 GO:0030674 protein binding, bridging(GO:0030674)
0.1 17.0 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 0.5 GO:0030250 cyclase activator activity(GO:0010853) guanylate cyclase activator activity(GO:0030250)
0.1 0.9 GO:0070513 death domain binding(GO:0070513)
0.1 0.2 GO:0008511 sodium:potassium:chloride symporter activity(GO:0008511)
0.0 0.3 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.0 18.9 GO:0030246 carbohydrate binding(GO:0030246)
0.0 2.3 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.0 2.1 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 3.8 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 1.1 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 4.9 GO:0016651 oxidoreductase activity, acting on NAD(P)H(GO:0016651)
0.0 0.6 GO:0015101 organic cation transmembrane transporter activity(GO:0015101)
0.0 7.0 GO:0016787 hydrolase activity(GO:0016787)
0.0 3.7 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.0 0.2 GO:0004859 phospholipase inhibitor activity(GO:0004859)
0.0 11.4 GO:0005543 phospholipid binding(GO:0005543)
0.0 0.5 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.0 0.2 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.0 0.2 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)
0.0 4.3 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 0.3 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 9.2 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.0 0.4 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.0 8.1 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 113.5 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.9 83.4 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.7 79.2 PID FGF PATHWAY FGF signaling pathway
0.4 25.4 PID CD40 PATHWAY CD40/CD40L signaling
0.4 16.8 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.3 29.5 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.2 13.7 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.2 16.2 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 35.8 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 8.0 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
0.1 9.0 PID BMP PATHWAY BMP receptor signaling
0.1 4.1 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.1 29.4 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 5.5 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.1 3.8 PID BARD1 PATHWAY BARD1 signaling events
0.1 4.6 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 4.3 PID E2F PATHWAY E2F transcription factor network
0.0 1.4 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 1.1 PID IL6 7 PATHWAY IL6-mediated signaling events
0.0 4.7 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.9 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 1.1 PID RHOA REG PATHWAY Regulation of RhoA activity

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
5.8 117.0 REACTOME COMMON PATHWAY Genes involved in Common Pathway
4.7 79.7 REACTOME FGFR4 LIGAND BINDING AND ACTIVATION Genes involved in FGFR4 ligand binding and activation
2.0 51.9 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
1.5 78.1 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
1.5 105.9 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
1.2 20.9 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
1.1 48.3 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.8 41.1 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.6 31.3 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.4 28.1 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.4 22.4 REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D Genes involved in Metabolism of steroid hormones and vitamins A and D
0.4 10.2 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.3 7.9 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
0.3 4.6 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.3 30.6 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.2 4.1 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.2 2.7 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.2 2.3 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.1 2.3 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.1 3.8 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.1 8.3 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.1 12.1 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 3.2 REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.1 2.5 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.1 7.6 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.7 REACTOME FGFR LIGAND BINDING AND ACTIVATION Genes involved in FGFR ligand binding and activation
0.0 1.4 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 4.9 REACTOME TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION Genes involved in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
0.0 9.8 REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS Genes involved in Class A/1 (Rhodopsin-like receptors)
0.0 3.8 REACTOME MRNA PROCESSING Genes involved in mRNA Processing
0.0 1.2 REACTOME TRAFFICKING OF AMPA RECEPTORS Genes involved in Trafficking of AMPA receptors
0.0 0.3 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.0 0.5 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions