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SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for HOXA2_HOXB1

Z-value: 0.59

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Transcription factors associated with HOXA2_HOXB1

Gene Symbol Gene ID Gene Info
HOXA2
ENSG00000105996.5 homeobox A2
HOXB1
ENSG00000120094.6 homeobox B1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HOXA2hg19_v2_chr7_-_27142290_27142430-0.784.7e-05Click!
HOXB1hg19_v2_chr17_-_46608272_466083850.623.8e-03Click!

Activity profile of HOXA2_HOXB1 motif

Sorted Z-values of HOXA2_HOXB1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr11_+_57365150 2.60 ENST00000457869.1
ENST00000340687.6
ENST00000378323.4
ENST00000378324.2
ENST00000403558.1
SERPING1
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
chr4_-_90756769 2.55 ENST00000345009.4
ENST00000505199.1
ENST00000502987.1
SNCA
synuclein, alpha (non A4 component of amyloid precursor)
chr4_-_90757364 2.54 ENST00000508895.1
SNCA
synuclein, alpha (non A4 component of amyloid precursor)
chr3_+_189507460 2.19 ENST00000434928.1
TP63
tumor protein p63
chr14_-_81893734 2.07 ENST00000555447.1
STON2
stonin 2
chr3_+_189507523 2.02 ENST00000437221.1
ENST00000392463.2
ENST00000392461.3
ENST00000449992.1
ENST00000456148.1
TP63
tumor protein p63
chr10_-_105615164 1.85 ENST00000355946.2
ENST00000369774.4
SH3PXD2A
SH3 and PX domains 2A
chr2_+_12857043 1.68 ENST00000381465.2
TRIB2
tribbles pseudokinase 2
chr3_+_189507432 1.63 ENST00000354600.5
TP63
tumor protein p63
chr4_-_102267953 1.58 ENST00000523694.2
ENST00000507176.1
PPP3CA
protein phosphatase 3, catalytic subunit, alpha isozyme
chr2_+_12857015 1.50 ENST00000155926.4
TRIB2
tribbles pseudokinase 2
chr5_+_167181917 1.47 ENST00000519204.1
TENM2
teneurin transmembrane protein 2
chr12_-_28124903 1.41 ENST00000395872.1
ENST00000354417.3
ENST00000201015.4
PTHLH
parathyroid hormone-like hormone
chr15_-_93616892 1.34 ENST00000556658.1
ENST00000538818.1
ENST00000425933.2
RGMA
repulsive guidance molecule family member a
chr15_-_93616340 1.34 ENST00000557420.1
ENST00000542321.2
RGMA
repulsive guidance molecule family member a
chr12_-_28125638 1.33 ENST00000545234.1
PTHLH
parathyroid hormone-like hormone
chrX_-_30993201 1.23 ENST00000288422.2
ENST00000378932.2
TAB3
TGF-beta activated kinase 1/MAP3K7 binding protein 3
chr1_-_8763278 1.16 ENST00000468247.1
RERE
arginine-glutamic acid dipeptide (RE) repeats
chr17_+_7758374 1.12 ENST00000301599.6
ENST00000574668.1
TMEM88
transmembrane protein 88
chr5_-_125930929 1.11 ENST00000553117.1
ENST00000447989.2
ENST00000409134.3
ALDH7A1
aldehyde dehydrogenase 7 family, member A1
chr1_+_68150744 1.09 ENST00000370986.4
ENST00000370985.3
GADD45A
growth arrest and DNA-damage-inducible, alpha
chr19_-_51512804 1.02 ENST00000594211.1
ENST00000376832.4
KLK9
kallikrein-related peptidase 9
chr7_-_27170352 1.00 ENST00000428284.2
ENST00000360046.5
HOXA4
homeobox A4
chr9_+_132099158 0.97 ENST00000444125.1
RP11-65J3.1
RP11-65J3.1
chr5_-_125930877 0.97 ENST00000510111.2
ENST00000509270.1
ALDH7A1
aldehyde dehydrogenase 7 family, member A1
chr14_-_24733444 0.95 ENST00000560478.1
ENST00000560443.1
TGM1
transglutaminase 1
chrX_+_99899180 0.95 ENST00000373004.3
SRPX2
sushi-repeat containing protein, X-linked 2
chr11_-_111782696 0.90 ENST00000227251.3
ENST00000526180.1
CRYAB
crystallin, alpha B
chr11_-_2162162 0.89 ENST00000381389.1
IGF2
insulin-like growth factor 2 (somatomedin A)
chr2_-_45236540 0.84 ENST00000303077.6
SIX2
SIX homeobox 2
chr20_+_52105495 0.80 ENST00000439873.2
AL354993.1
Cell growth-inhibiting protein 7; HCG1784586; Uncharacterized protein
chr17_+_48609903 0.78 ENST00000268933.3
EPN3
epsin 3
chr1_-_67390474 0.74 ENST00000371023.3
ENST00000371022.3
ENST00000371026.3
ENST00000431318.1
WDR78
WD repeat domain 78
chr9_-_73029540 0.73 ENST00000377126.2
KLF9
Kruppel-like factor 9
chr8_-_128231299 0.73 ENST00000500112.1
CCAT1
colon cancer associated transcript 1 (non-protein coding)
chr14_-_21516590 0.68 ENST00000555026.1
NDRG2
NDRG family member 2
chr5_+_145826867 0.68 ENST00000296702.5
ENST00000394421.2
TCERG1
transcription elongation regulator 1
chr5_+_154181816 0.66 ENST00000518677.1
LARP1
La ribonucleoprotein domain family, member 1
chr19_+_37997812 0.64 ENST00000542455.1
ENST00000587143.1
ZNF793
zinc finger protein 793
chr19_+_13051206 0.60 ENST00000586760.1
CALR
calreticulin
chr10_+_102891048 0.58 ENST00000467928.2
TLX1
T-cell leukemia homeobox 1
chr21_-_43430440 0.58 ENST00000398505.3
ENST00000310826.5
ENST00000449949.1
ENST00000398499.1
ENST00000398497.2
ENST00000398511.3
ZBTB21
zinc finger and BTB domain containing 21
chr1_-_109584608 0.56 ENST00000400794.3
ENST00000528747.1
ENST00000369962.3
ENST00000361054.3
WDR47
WD repeat domain 47
chr9_+_124329336 0.56 ENST00000394340.3
ENST00000436835.1
ENST00000259371.2
DAB2IP
DAB2 interacting protein
chr17_+_36584662 0.55 ENST00000431231.2
ENST00000437668.3
ARHGAP23
Rho GTPase activating protein 23
chr10_+_24755416 0.52 ENST00000396446.1
ENST00000396445.1
ENST00000376451.2
KIAA1217
KIAA1217
chr11_-_111782484 0.52 ENST00000533971.1
CRYAB
crystallin, alpha B
chr1_+_178062855 0.49 ENST00000448150.3
RASAL2
RAS protein activator like 2
chr1_+_36621174 0.48 ENST00000429533.2
MAP7D1
MAP7 domain containing 1
chr11_+_68228186 0.46 ENST00000393799.2
ENST00000393800.2
ENST00000528635.1
ENST00000533127.1
ENST00000529907.1
ENST00000529344.1
ENST00000534534.1
ENST00000524845.1
ENST00000265637.4
ENST00000524904.1
ENST00000393801.3
ENST00000265636.5
ENST00000529710.1
PPP6R3
protein phosphatase 6, regulatory subunit 3
chr1_-_205391178 0.45 ENST00000367153.4
ENST00000367151.2
ENST00000391936.2
ENST00000367149.3
LEMD1
LEM domain containing 1
chr1_-_109584768 0.44 ENST00000357672.3
WDR47
WD repeat domain 47
chr9_-_26946981 0.43 ENST00000523212.1
PLAA
phospholipase A2-activating protein
chr7_+_20370746 0.43 ENST00000222573.4
ITGB8
integrin, beta 8
chr8_-_101730061 0.42 ENST00000519100.1
PABPC1
poly(A) binding protein, cytoplasmic 1
chr1_+_12524965 0.41 ENST00000471923.1
VPS13D
vacuolar protein sorting 13 homolog D (S. cerevisiae)
chr1_-_109584716 0.40 ENST00000531337.1
ENST00000529074.1
ENST00000369965.4
WDR47
WD repeat domain 47
chr12_+_10658489 0.37 ENST00000538173.1
EIF2S3L
Putative eukaryotic translation initiation factor 2 subunit 3-like protein
chr7_-_143956815 0.36 ENST00000493325.1
OR2A7
olfactory receptor, family 2, subfamily A, member 7
chr1_+_67390578 0.35 ENST00000371018.3
ENST00000355977.6
ENST00000357692.2
ENST00000401041.1
ENST00000371016.1
ENST00000371014.1
ENST00000371012.2
MIER1
mesoderm induction early response 1, transcriptional regulator
chr2_+_68961934 0.34 ENST00000409202.3
ARHGAP25
Rho GTPase activating protein 25
chr11_-_122929699 0.34 ENST00000526686.1
HSPA8
heat shock 70kDa protein 8
chr6_+_32006042 0.33 ENST00000418967.2
CYP21A2
cytochrome P450, family 21, subfamily A, polypeptide 2
chr2_+_54684327 0.31 ENST00000389980.3
SPTBN1
spectrin, beta, non-erythrocytic 1
chr2_+_68961905 0.31 ENST00000295381.3
ARHGAP25
Rho GTPase activating protein 25
chr2_+_242089833 0.30 ENST00000404405.3
ENST00000439916.1
ENST00000406106.3
ENST00000401987.1
PPP1R7
protein phosphatase 1, regulatory subunit 7
chr6_-_159065741 0.30 ENST00000367085.3
ENST00000367089.3
DYNLT1
dynein, light chain, Tctex-type 1
chr2_+_68962014 0.30 ENST00000467265.1
ARHGAP25
Rho GTPase activating protein 25
chr11_-_93583697 0.29 ENST00000409977.1
VSTM5
V-set and transmembrane domain containing 5
chr7_-_27135591 0.28 ENST00000343060.4
ENST00000355633.5
HOXA1
homeobox A1
chr10_-_75457554 0.28 ENST00000374094.4
ENST00000443782.2
AGAP5
ArfGAP with GTPase domain, ankyrin repeat and PH domain 5
chr1_-_217804377 0.27 ENST00000366935.3
ENST00000366934.3
GPATCH2
G patch domain containing 2
chr6_+_32006159 0.25 ENST00000478281.1
ENST00000471671.1
ENST00000435122.2
CYP21A2
cytochrome P450, family 21, subfamily A, polypeptide 2
chr1_+_52082751 0.25 ENST00000447887.1
ENST00000435686.2
ENST00000428468.1
ENST00000453295.1
OSBPL9
oxysterol binding protein-like 9
chr13_-_36050819 0.24 ENST00000379919.4
MAB21L1
mab-21-like 1 (C. elegans)
chr12_+_57610562 0.23 ENST00000349394.5
NXPH4
neurexophilin 4
chr16_-_49890016 0.22 ENST00000563137.2
ZNF423
zinc finger protein 423
chr18_-_53070913 0.22 ENST00000568186.1
ENST00000564228.1
TCF4
transcription factor 4
chr13_+_52586517 0.21 ENST00000523764.1
ENST00000521508.1
ALG11
ALG11, alpha-1,2-mannosyltransferase
chr12_-_15038779 0.21 ENST00000228938.5
ENST00000539261.1
MGP
matrix Gla protein
chr19_+_44645700 0.20 ENST00000592437.1
ZNF234
zinc finger protein 234
chr10_-_65028817 0.20 ENST00000542921.1
JMJD1C
jumonji domain containing 1C
chr5_-_179045199 0.19 ENST00000523921.1
HNRNPH1
heterogeneous nuclear ribonucleoprotein H1 (H)
chr9_-_26947220 0.19 ENST00000520884.1
PLAA
phospholipase A2-activating protein
chr17_+_37824411 0.19 ENST00000269582.2
PNMT
phenylethanolamine N-methyltransferase
chr9_-_15250114 0.19 ENST00000507993.1
TTC39B
tetratricopeptide repeat domain 39B
chr11_-_122930121 0.19 ENST00000524552.1
HSPA8
heat shock 70kDa protein 8
chr13_+_97928395 0.18 ENST00000445661.2
MBNL2
muscleblind-like splicing regulator 2
chr7_-_86595190 0.18 ENST00000398276.2
ENST00000416314.1
ENST00000425689.1
KIAA1324L
KIAA1324-like
chr10_-_98945515 0.17 ENST00000371070.4
SLIT1
slit homolog 1 (Drosophila)
chr19_+_44645731 0.17 ENST00000426739.2
ZNF234
zinc finger protein 234
chr10_-_65028938 0.16 ENST00000402544.1
JMJD1C
jumonji domain containing 1C
chr10_-_98945264 0.16 ENST00000314867.5
SLIT1
slit homolog 1 (Drosophila)
chr9_-_101471479 0.16 ENST00000259455.2
GABBR2
gamma-aminobutyric acid (GABA) B receptor, 2
chr15_+_81591757 0.15 ENST00000558332.1
IL16
interleukin 16
chr17_+_1173853 0.15 ENST00000391429.1
BHLHA9
basic helix-loop-helix family, member a9
chr11_+_133902547 0.15 ENST00000529070.1
RP11-713P17.3
RP11-713P17.3
chr4_+_77356248 0.15 ENST00000296043.6
SHROOM3
shroom family member 3
chr17_-_1588101 0.14 ENST00000577001.1
ENST00000572621.1
ENST00000304992.6
PRPF8
pre-mRNA processing factor 8
chr10_-_98945677 0.14 ENST00000266058.4
ENST00000371041.3
SLIT1
slit homolog 1 (Drosophila)
chr17_-_42277203 0.14 ENST00000587097.1
ATXN7L3
ataxin 7-like 3
chr10_-_46342921 0.13 ENST00000448048.2
AGAP4
ArfGAP with GTPase domain, ankyrin repeat and PH domain 4
chr7_+_86273218 0.12 ENST00000361669.2
GRM3
glutamate receptor, metabotropic 3
chr3_+_239652 0.12 ENST00000435603.1
CHL1
cell adhesion molecule L1-like
chr1_+_243419306 0.12 ENST00000355875.4
ENST00000391846.1
ENST00000366541.3
ENST00000343783.6
SDCCAG8
serologically defined colon cancer antigen 8
chr15_+_48009541 0.12 ENST00000536845.2
ENST00000558816.1
SEMA6D
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
chr5_+_98109322 0.12 ENST00000513185.1
RGMB
repulsive guidance molecule family member b
chr8_-_38008783 0.11 ENST00000276449.4
STAR
steroidogenic acute regulatory protein
chr3_-_72150076 0.11 ENST00000488545.1
ENST00000608654.1
LINC00877
long intergenic non-protein coding RNA 877
chr5_-_145895753 0.10 ENST00000311104.2
GPR151
G protein-coupled receptor 151
chr2_+_26624775 0.10 ENST00000288710.2
DRC1
dynein regulatory complex subunit 1 homolog (Chlamydomonas)
chr6_-_112575912 0.10 ENST00000522006.1
ENST00000230538.7
ENST00000519932.1
LAMA4
laminin, alpha 4
chr6_-_112575687 0.10 ENST00000521398.1
ENST00000424408.2
ENST00000243219.3
LAMA4
laminin, alpha 4
chr12_+_56414851 0.10 ENST00000547167.1
IKZF4
IKAROS family zinc finger 4 (Eos)
chr19_-_12997995 0.10 ENST00000264834.4
KLF1
Kruppel-like factor 1 (erythroid)
chr2_+_135011731 0.09 ENST00000281923.2
MGAT5
mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
chr12_+_7282795 0.09 ENST00000266546.6
CLSTN3
calsyntenin 3
chr9_-_26947453 0.09 ENST00000397292.3
PLAA
phospholipase A2-activating protein
chr19_+_52074502 0.09 ENST00000545217.1
ENST00000262259.2
ENST00000596504.1
ZNF175
zinc finger protein 175
chr7_+_1272522 0.09 ENST00000316333.8
UNCX
UNC homeobox
chrX_+_125953746 0.09 ENST00000371125.3
CXorf64
chromosome X open reading frame 64
chr3_+_150264458 0.08 ENST00000487799.1
ENST00000460851.1
EIF2A
eukaryotic translation initiation factor 2A, 65kDa
chr8_-_67874805 0.08 ENST00000563496.1
TCF24
transcription factor 24
chr6_+_33387868 0.07 ENST00000418600.2
SYNGAP1
synaptic Ras GTPase activating protein 1
chr16_-_54972581 0.07 ENST00000559802.1
ENST00000558156.1
CTD-3032H12.1
CTD-3032H12.1
chr6_+_73331520 0.06 ENST00000342056.2
ENST00000355194.4
KCNQ5
potassium voltage-gated channel, KQT-like subfamily, member 5
chr16_+_66429358 0.06 ENST00000539168.1
CDH5
cadherin 5, type 2 (vascular endothelium)
chr7_+_26591441 0.05 ENST00000420912.1
ENST00000457000.1
ENST00000430426.1
AC004947.2
AC004947.2
chr2_-_23747214 0.05 ENST00000430988.1
AC011239.1
Uncharacterized protein
chr6_-_112575758 0.04 ENST00000431543.2
ENST00000453937.2
ENST00000368638.4
ENST00000389463.4
LAMA4
laminin, alpha 4
chr12_+_57482877 0.04 ENST00000342556.6
ENST00000357680.4
NAB2
NGFI-A binding protein 2 (EGR1 binding protein 2)
chr3_+_191046810 0.04 ENST00000392455.3
ENST00000392456.3
CCDC50
coiled-coil domain containing 50
chr20_+_30467600 0.04 ENST00000375934.4
ENST00000375922.4
TTLL9
tubulin tyrosine ligase-like family, member 9
chr14_+_68189190 0.04 ENST00000539142.1
RDH12
retinol dehydrogenase 12 (all-trans/9-cis/11-cis)
chr12_+_57390745 0.03 ENST00000600202.1
HBCBP
HBcAg-binding protein; Uncharacterized protein
chr6_+_155334780 0.03 ENST00000538270.1
ENST00000535231.1
TIAM2
T-cell lymphoma invasion and metastasis 2
chr1_-_223536679 0.02 ENST00000608996.1
SUSD4
sushi domain containing 4
chr7_-_120497178 0.02 ENST00000441017.1
ENST00000424710.1
ENST00000433758.1
TSPAN12
tetraspanin 12
chr1_-_108507631 0.02 ENST00000527011.1
ENST00000370056.4
VAV3
vav 3 guanine nucleotide exchange factor
chr21_+_19617140 0.02 ENST00000299295.2
ENST00000338326.3
CHODL
chondrolectin
chr12_-_114843889 0.02 ENST00000405440.2
TBX5
T-box 5
chr6_-_112575838 0.01 ENST00000455073.1
LAMA4
laminin, alpha 4
chr2_-_154335300 0.01 ENST00000325926.3
RPRM
reprimo, TP53 dependent G2 arrest mediator candidate
chrX_-_45629661 0.01 ENST00000602507.1
ENST00000602461.1
RP6-99M1.2
RP6-99M1.2
chr16_-_11617444 0.01 ENST00000598234.1
CTD-3088G3.8
Protein LOC388210
chr12_-_86650077 0.01 ENST00000552808.2
ENST00000547225.1
MGAT4C
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr20_-_45976816 0.01 ENST00000441977.1
ZMYND8
zinc finger, MYND-type containing 8
chr2_-_44588679 0.00 ENST00000409411.1
PREPL
prolyl endopeptidase-like
chr8_-_143961236 0.00 ENST00000377675.3
ENST00000517471.1
ENST00000292427.4
CYP11B1
cytochrome P450, family 11, subfamily B, polypeptide 1
chr12_-_88423164 0.00 ENST00000298699.2
ENST00000550553.1
C12orf50
chromosome 12 open reading frame 50

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXA2_HOXB1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 5.8 GO:0007499 ectoderm and mesoderm interaction(GO:0007499)
1.1 3.2 GO:0045081 negative regulation of interleukin-10 biosynthetic process(GO:0045081)
1.0 5.1 GO:1903284 negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) positive regulation of peroxidase activity(GO:2000470)
0.5 2.1 GO:0019285 glycine betaine biosynthetic process from choline(GO:0019285) glycine betaine metabolic process(GO:0031455) glycine betaine biosynthetic process(GO:0031456)
0.4 1.6 GO:1905205 positive regulation of connective tissue replacement(GO:1905205)
0.3 1.9 GO:0072675 multinuclear osteoclast differentiation(GO:0072674) osteoclast fusion(GO:0072675)
0.2 2.6 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.2 1.2 GO:0021691 cerebellar Purkinje cell layer maturation(GO:0021691)
0.2 0.8 GO:0072137 condensed mesenchymal cell proliferation(GO:0072137)
0.2 0.5 GO:0021834 chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration(GO:0021834)
0.1 0.9 GO:0045229 cell envelope organization(GO:0043163) external encapsulating structure organization(GO:0045229)
0.1 0.6 GO:0043553 vascular endothelial growth factor receptor-2 signaling pathway(GO:0036324) negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.1 0.7 GO:0072752 cellular response to rapamycin(GO:0072752)
0.1 2.7 GO:0048681 negative regulation of axon regeneration(GO:0048681)
0.1 0.5 GO:1902904 negative regulation of fibril organization(GO:1902904) chaperone-mediated autophagy translocation complex disassembly(GO:1904764)
0.1 0.7 GO:0051414 response to cortisol(GO:0051414)
0.1 0.6 GO:0002501 peptide antigen assembly with MHC protein complex(GO:0002501)
0.1 0.9 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028) positive regulation of glycogen (starch) synthase activity(GO:2000467)
0.1 1.5 GO:0097264 self proteolysis(GO:0097264)
0.1 1.4 GO:0007021 tubulin complex assembly(GO:0007021)
0.1 0.3 GO:1900042 positive regulation of interleukin-2 secretion(GO:1900042)
0.1 0.3 GO:0051708 intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
0.0 1.7 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)
0.0 0.9 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.0 1.1 GO:1900745 positive regulation of p38MAPK cascade(GO:1900745)
0.0 0.7 GO:0090360 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
0.0 0.1 GO:0018963 phthalate metabolic process(GO:0018963)
0.0 0.4 GO:2000622 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.0 0.1 GO:0060285 cilium-dependent cell motility(GO:0060285)
0.0 0.6 GO:0008212 mineralocorticoid biosynthetic process(GO:0006705) mineralocorticoid metabolic process(GO:0008212)
0.0 0.1 GO:0042418 epinephrine biosynthetic process(GO:0042418)
0.0 2.1 GO:0048488 synaptic vesicle endocytosis(GO:0048488)
0.0 0.7 GO:0010992 ubiquitin homeostasis(GO:0010992)
0.0 0.5 GO:0048706 embryonic skeletal system development(GO:0048706)
0.0 0.1 GO:1990928 response to amino acid starvation(GO:1990928)
0.0 0.3 GO:0048752 semicircular canal morphogenesis(GO:0048752)
0.0 0.3 GO:0031937 positive regulation of chromatin silencing(GO:0031937)
0.0 1.2 GO:0002755 MyD88-dependent toll-like receptor signaling pathway(GO:0002755)
0.0 0.4 GO:0033169 histone H3-K9 demethylation(GO:0033169)
0.0 0.4 GO:0001573 ganglioside metabolic process(GO:0001573)
0.0 0.1 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.0 0.1 GO:1902474 positive regulation of protein localization to synapse(GO:1902474)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:1990032 parallel fiber(GO:1990032)
0.2 1.6 GO:0005955 calcineurin complex(GO:0005955)
0.1 0.4 GO:0034686 integrin alphav-beta8 complex(GO:0034686)
0.1 5.1 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.1 1.4 GO:0097512 cardiac myofibril(GO:0097512)
0.1 0.5 GO:0098575 lumenal side of lysosomal membrane(GO:0098575)
0.1 0.6 GO:0042824 MHC class I peptide loading complex(GO:0042824)
0.0 5.8 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 0.7 GO:0031931 TORC1 complex(GO:0031931)
0.0 0.3 GO:0032437 cuticular plate(GO:0032437)
0.0 0.2 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.0 0.7 GO:0005858 axonemal dynein complex(GO:0005858)
0.0 3.2 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 1.9 GO:0002102 podosome(GO:0002102)
0.0 0.4 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 0.9 GO:0001533 cornified envelope(GO:0001533)
0.0 0.4 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 2.8 GO:0031225 anchored component of membrane(GO:0031225)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 5.1 GO:0060961 phospholipase D inhibitor activity(GO:0060961)
0.4 5.8 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.2 1.2 GO:0008267 poly-glutamine tract binding(GO:0008267)
0.2 0.8 GO:1990175 EH domain binding(GO:1990175)
0.2 0.7 GO:0016005 phospholipase A2 activator activity(GO:0016005)
0.2 3.2 GO:0055106 ubiquitin-protein transferase regulator activity(GO:0055106)
0.2 2.7 GO:1990459 transferrin receptor binding(GO:1990459)
0.1 0.4 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.1 1.6 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.1 1.9 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.1 0.6 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
0.1 2.7 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.1 0.9 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.1 0.6 GO:0001849 complement component C1q binding(GO:0001849)
0.1 2.1 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029)
0.1 1.4 GO:0005212 structural constituent of eye lens(GO:0005212)
0.1 0.2 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.1 1.1 GO:0008494 translation activator activity(GO:0008494)
0.0 0.5 GO:0055131 C3HC4-type RING finger domain binding(GO:0055131)
0.0 0.5 GO:0048495 Roundabout binding(GO:0048495)
0.0 0.7 GO:0045504 dynein heavy chain binding(GO:0045504)
0.0 0.2 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.0 0.1 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
0.0 0.9 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.0 0.1 GO:0001641 group II metabotropic glutamate receptor activity(GO:0001641)
0.0 0.7 GO:0070064 proline-rich region binding(GO:0070064)
0.0 0.1 GO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
0.0 0.5 GO:0019903 protein phosphatase binding(GO:0019903)
0.0 0.6 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 0.6 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.0 2.0 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.4 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 0.2 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 6.9 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 5.1 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.0 1.8 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 1.6 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 2.4 PID BMP PATHWAY BMP receptor signaling
0.0 1.4 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 0.4 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 3.6 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.6 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.1 1.2 REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.1 5.1 REACTOME AMYLOIDS Genes involved in Amyloids
0.0 0.6 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 3.3 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 0.9 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.6 REACTOME ENDOGENOUS STEROLS Genes involved in Endogenous sterols
0.0 1.6 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 2.7 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.3 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 0.5 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation