Project

SARS-CoV-2 Analysis Results (GEO series: GSE147507)

Navigation
Downloads

Results for HOXB13

Z-value: 0.52

Motif logo

logo of

Transcription factors associated with HOXB13

Gene Symbol Gene ID Gene Info
HOXB13
ENSG00000159184.7 homeobox B13

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HOXB13hg19_v2_chr17_-_46806540_468065580.793.3e-05Click!

Activity profile of HOXB13 motif

Sorted Z-values of HOXB13 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr15_+_66994561 2.43 ENST00000288840.5
SMAD6
SMAD family member 6
chr1_+_66458072 1.75 ENST00000423207.2
PDE4B
phosphodiesterase 4B, cAMP-specific
chr17_-_46806540 1.56 ENST00000290295.7
HOXB13
homeobox B13
chr7_+_128784712 1.29 ENST00000289407.4
TSPAN33
tetraspanin 33
chr16_-_2205352 1.26 ENST00000563192.1
RP11-304L19.5
RP11-304L19.5
chr7_-_11871815 1.12 ENST00000423059.4
THSD7A
thrombospondin, type I, domain containing 7A
chr12_-_52715179 1.03 ENST00000293670.3
KRT83
keratin 83
chr3_-_114790179 1.01 ENST00000462705.1
ZBTB20
zinc finger and BTB domain containing 20
chr11_+_47279155 0.86 ENST00000444396.1
ENST00000457932.1
ENST00000412937.1
NR1H3
nuclear receptor subfamily 1, group H, member 3
chr18_+_68002675 0.85 ENST00000584919.1
RP11-41O4.1
Uncharacterized protein
chr19_+_56154913 0.82 ENST00000270451.5
ENST00000588537.1
ZNF581
zinc finger protein 581
chr2_-_176046391 0.80 ENST00000392541.3
ENST00000409194.1
ATP5G3
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)
chr5_-_140053152 0.74 ENST00000542735.1
DND1
DND microRNA-mediated repression inhibitor 1
chr2_-_190044480 0.73 ENST00000374866.3
COL5A2
collagen, type V, alpha 2
chr8_+_35649365 0.67 ENST00000437887.1
AC012215.1
Uncharacterized protein
chr2_+_74685413 0.65 ENST00000233615.2
WBP1
WW domain binding protein 1
chr17_-_73663168 0.56 ENST00000578201.1
ENST00000423245.2
RECQL5
RecQ protein-like 5
chr22_-_38240316 0.53 ENST00000411961.2
ENST00000434930.1
ANKRD54
ankyrin repeat domain 54
chr5_+_135496675 0.53 ENST00000507637.1
SMAD5
SMAD family member 5
chr8_+_77593448 0.52 ENST00000521891.2
ZFHX4
zinc finger homeobox 4
chr1_-_36863481 0.52 ENST00000315732.2
LSM10
LSM10, U7 small nuclear RNA associated
chr17_-_73663245 0.46 ENST00000584999.1
ENST00000317905.5
ENST00000420326.2
ENST00000340830.5
RECQL5
RecQ protein-like 5
chr4_+_169575875 0.44 ENST00000503457.1
PALLD
palladin, cytoskeletal associated protein
chr19_-_5903714 0.43 ENST00000586349.1
ENST00000585661.1
ENST00000308961.4
ENST00000592634.1
ENST00000418389.2
ENST00000252675.5
AC024592.12
NDUFA11
FUT5
Uncharacterized protein
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa
fucosyltransferase 5 (alpha (1,3) fucosyltransferase)
chr2_+_74685527 0.38 ENST00000393972.3
ENST00000409737.1
ENST00000428943.1
WBP1
WW domain binding protein 1
chr4_+_95972822 0.38 ENST00000509540.1
ENST00000440890.2
BMPR1B
bone morphogenetic protein receptor, type IB
chr6_-_116833500 0.36 ENST00000356128.4
TRAPPC3L
trafficking protein particle complex 3-like
chr4_-_164534657 0.33 ENST00000339875.5
MARCH1
membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase
chr2_+_67624430 0.32 ENST00000272342.5
ETAA1
Ewing tumor-associated antigen 1
chr17_-_10560619 0.30 ENST00000583535.1
MYH3
myosin, heavy chain 3, skeletal muscle, embryonic
chr2_-_69180083 0.30 ENST00000328895.4
GKN2
gastrokine 2
chr19_+_35634146 0.29 ENST00000586063.1
ENST00000270310.2
ENST00000588265.1
FXYD7
FXYD domain containing ion transport regulator 7
chr14_-_72458326 0.28 ENST00000542853.1
AC005477.1
AC005477.1
chr2_-_69180012 0.28 ENST00000481498.1
GKN2
gastrokine 2
chr14_-_50583271 0.27 ENST00000395860.2
ENST00000395859.2
VCPKMT
valosin containing protein lysine (K) methyltransferase
chr18_-_73967160 0.27 ENST00000579714.1
RP11-94B19.7
RP11-94B19.7
chr8_+_119294456 0.27 ENST00000366457.2
AC023590.1
Uncharacterized protein
chr9_+_123884038 0.26 ENST00000373847.1
CNTRL
centriolin
chr3_+_68053359 0.26 ENST00000478136.1
FAM19A1
family with sequence similarity 19 (chemokine (C-C motif)-like), member A1
chr9_-_107367951 0.25 ENST00000542196.1
OR13C2
olfactory receptor, family 13, subfamily C, member 2
chr21_+_30672433 0.25 ENST00000451655.1
BACH1
BTB and CNC homology 1, basic leucine zipper transcription factor 1
chr4_+_68424434 0.23 ENST00000265404.2
ENST00000396225.1
STAP1
signal transducing adaptor family member 1
chr3_+_89156799 0.21 ENST00000452448.2
ENST00000494014.1
EPHA3
EPH receptor A3
chr12_+_8309630 0.20 ENST00000396570.3
ZNF705A
zinc finger protein 705A
chr16_-_71610985 0.20 ENST00000355962.4
TAT
tyrosine aminotransferase
chr19_+_1440838 0.19 ENST00000594262.1
AC027307.3
Uncharacterized protein
chr6_+_27782788 0.19 ENST00000359465.4
HIST1H2BM
histone cluster 1, H2bm
chr22_+_35462129 0.19 ENST00000404699.2
ENST00000308700.6
ISX
intestine-specific homeobox
chr1_+_110993795 0.18 ENST00000271331.3
PROK1
prokineticin 1
chr8_+_77593474 0.18 ENST00000455469.2
ENST00000050961.6
ZFHX4
zinc finger homeobox 4
chr3_+_89156674 0.18 ENST00000336596.2
EPHA3
EPH receptor A3
chr15_-_55541227 0.17 ENST00000566877.1
RAB27A
RAB27A, member RAS oncogene family
chr6_-_27782548 0.17 ENST00000333151.3
HIST1H2AJ
histone cluster 1, H2aj
chr9_+_103947311 0.17 ENST00000395056.2
LPPR1
Lipid phosphate phosphatase-related protein type 1
chr1_+_84630645 0.16 ENST00000394839.2
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr4_+_110749143 0.16 ENST00000317735.4
RRH
retinal pigment epithelium-derived rhodopsin homolog
chr1_+_84630053 0.15 ENST00000394838.2
ENST00000370682.3
ENST00000432111.1
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr16_-_24942411 0.13 ENST00000571843.1
ARHGAP17
Rho GTPase activating protein 17
chr14_+_76776957 0.13 ENST00000512784.1
ESRRB
estrogen-related receptor beta
chr2_-_136288113 0.13 ENST00000401392.1
ZRANB3
zinc finger, RAN-binding domain containing 3
chr15_+_48483736 0.13 ENST00000417307.2
ENST00000559641.1
CTXN2
SLC12A1
cortexin 2
solute carrier family 12 (sodium/potassium/chloride transporter), member 1
chr9_-_104198042 0.13 ENST00000374855.4
ALDOB
aldolase B, fructose-bisphosphate
chr5_-_159766528 0.11 ENST00000505287.2
CCNJL
cyclin J-like
chr1_+_84630352 0.11 ENST00000450730.1
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr7_+_35756186 0.11 ENST00000430518.1
AC018647.3
AC018647.3
chr16_-_24942273 0.11 ENST00000571406.1
ARHGAP17
Rho GTPase activating protein 17
chr9_+_44868935 0.10 ENST00000448436.2
RP11-160N1.10
RP11-160N1.10
chr1_+_78769549 0.10 ENST00000370758.1
PTGFR
prostaglandin F receptor (FP)
chr18_-_52989525 0.10 ENST00000457482.3
TCF4
transcription factor 4
chr16_-_80926457 0.10 ENST00000563626.1
ENST00000562231.1
RP11-314O13.1
RP11-314O13.1
chr7_-_50860565 0.09 ENST00000403097.1
GRB10
growth factor receptor-bound protein 10
chr12_-_81992111 0.08 ENST00000443686.3
ENST00000407050.4
PPFIA2
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
chr7_+_35756092 0.08 ENST00000458087.3
AC018647.3
AC018647.3
chr1_-_151148492 0.08 ENST00000295314.4
TMOD4
tropomodulin 4 (muscle)
chr17_-_39646116 0.07 ENST00000328119.6
KRT36
keratin 36
chr12_-_94673956 0.07 ENST00000551941.1
RP11-1105G2.3
Uncharacterized protein
chr6_-_139613269 0.06 ENST00000358430.3
TXLNB
taxilin beta
chr18_+_3252206 0.05 ENST00000578562.2
MYL12A
myosin, light chain 12A, regulatory, non-sarcomeric
chr2_+_173724771 0.05 ENST00000538974.1
ENST00000540783.1
RAPGEF4
Rap guanine nucleotide exchange factor (GEF) 4
chr1_-_12679171 0.05 ENST00000606790.1
RP11-474O21.5
RP11-474O21.5
chr22_-_38240412 0.04 ENST00000215941.4
ANKRD54
ankyrin repeat domain 54
chr3_-_123710199 0.03 ENST00000184183.4
ROPN1
rhophilin associated tail protein 1
chr7_+_35756066 0.03 ENST00000449644.1
AC018647.3
AC018647.3
chr9_+_125132803 0.03 ENST00000540753.1
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr1_+_84630367 0.02 ENST00000370680.1
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr7_+_16700806 0.02 ENST00000446596.1
ENST00000438834.1
BZW2
basic leucine zipper and W2 domains 2
chr9_-_130829588 0.02 ENST00000373078.4
NAIF1
nuclear apoptosis inducing factor 1
chrX_+_115301975 0.01 ENST00000371906.4
AGTR2
angiotensin II receptor, type 2
chr2_-_175629135 0.01 ENST00000409542.1
ENST00000409219.1
CHRNA1
cholinergic receptor, nicotinic, alpha 1 (muscle)
chr9_+_125133467 0.01 ENST00000426608.1
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr3_-_150690786 0.01 ENST00000327047.1
CLRN1
clarin 1
chr13_-_45768841 0.00 ENST00000379108.1
KCTD4
potassium channel tetramerization domain containing 4

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXB13

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.6 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743)
0.3 2.4 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
0.2 0.7 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.2 1.0 GO:1990414 replication-born double-strand break repair via sister chromatid exchange(GO:1990414)
0.2 0.9 GO:0090341 negative regulation of secretion of lysosomal enzymes(GO:0090341)
0.1 1.7 GO:1901078 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 0.4 GO:0097156 fasciculation of motor neuron axon(GO:0097156)
0.1 0.5 GO:0001880 Mullerian duct regression(GO:0001880)
0.1 0.2 GO:1903980 negative regulation of macrophage colony-stimulating factor signaling pathway(GO:1902227) negative regulation of response to macrophage colony-stimulating factor(GO:1903970) negative regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903973) positive regulation of microglial cell activation(GO:1903980)
0.1 0.3 GO:0000117 regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0000117)
0.1 0.2 GO:1904479 negative regulation of intestinal absorption(GO:1904479)
0.1 0.4 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.0 0.4 GO:0097338 response to clozapine(GO:0097338)
0.0 0.7 GO:0060965 negative regulation of gene silencing by miRNA(GO:0060965)
0.0 0.1 GO:0036292 DNA rewinding(GO:0036292)
0.0 0.4 GO:0019317 fucose catabolic process(GO:0019317) L-fucose metabolic process(GO:0042354) L-fucose catabolic process(GO:0042355)
0.0 0.2 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
0.0 0.8 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.0 0.2 GO:0006572 tyrosine catabolic process(GO:0006572)
0.0 0.1 GO:0006001 fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624)
0.0 1.0 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.0 0.4 GO:0003334 keratinocyte development(GO:0003334)
0.0 0.3 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.0 0.3 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.0 0.5 GO:1900087 positive regulation of G1/S transition of mitotic cell cycle(GO:1900087)
0.0 0.2 GO:0018298 protein-chromophore linkage(GO:0018298)
0.0 0.6 GO:0045648 positive regulation of erythrocyte differentiation(GO:0045648)
0.0 0.1 GO:0071799 response to prostaglandin D(GO:0071798) cellular response to prostaglandin D stimulus(GO:0071799)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0005588 collagen type V trimer(GO:0005588)
0.1 1.3 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.1 0.5 GO:0005683 U7 snRNP(GO:0005683)
0.0 1.7 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.8 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.4 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.0 0.4 GO:0030008 TRAPP complex(GO:0030008)
0.0 0.5 GO:0071141 SMAD protein complex(GO:0071141)
0.0 1.0 GO:0016591 DNA-directed RNA polymerase II, holoenzyme(GO:0016591)
0.0 0.4 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 1.0 GO:0045095 keratin filament(GO:0045095)
0.0 0.3 GO:0032982 myosin filament(GO:0032982)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.4 GO:0070698 transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity(GO:0030617) type I activin receptor binding(GO:0070698)
0.1 0.5 GO:0071209 U7 snRNA binding(GO:0071209)
0.1 1.0 GO:0009378 four-way junction helicase activity(GO:0009378)
0.1 0.9 GO:0032810 sterol response element binding(GO:0032810)
0.1 0.4 GO:0017060 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity(GO:0017060)
0.1 0.2 GO:0070546 L-phenylalanine aminotransferase activity(GO:0070546) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
0.0 0.1 GO:0008511 sodium:potassium:chloride symporter activity(GO:0008511)
0.0 0.3 GO:0017018 myosin phosphatase activity(GO:0017018)
0.0 1.7 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) gamma-tubulin binding(GO:0043015)
0.0 0.1 GO:0004958 prostaglandin F receptor activity(GO:0004958)
0.0 0.4 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 0.2 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
0.0 0.8 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 0.5 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0 0.7 GO:0035198 miRNA binding(GO:0035198)
0.0 0.4 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.0 0.4 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 1.0 GO:0050699 WW domain binding(GO:0050699)
0.0 0.2 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 0.4 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 0.1 GO:0036310 annealing helicase activity(GO:0036310)
0.0 0.2 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0 0.1 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 3.3 PID BMP PATHWAY BMP receptor signaling
0.0 0.9 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 1.6 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 0.7 NABA COLLAGENS Genes encoding collagen proteins

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.3 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 2.1 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 0.5 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0 0.2 REACTOME OPSINS Genes involved in Opsins