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SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for HOXB5

Z-value: 0.50

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Transcription factors associated with HOXB5

Gene Symbol Gene ID Gene Info
HOXB5
ENSG00000120075.5 homeobox B5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HOXB5hg19_v2_chr17_-_46671323_466713230.793.3e-05Click!

Activity profile of HOXB5 motif

Sorted Z-values of HOXB5 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr7_+_5322561 3.67 ENST00000396872.3
ENST00000444741.1
ENST00000297195.4
ENST00000406453.3
SLC29A4
solute carrier family 29 (equilibrative nucleoside transporter), member 4
chr19_-_16045220 2.90 ENST00000326742.8
CYP4F11
cytochrome P450, family 4, subfamily F, polypeptide 11
chr16_-_1821496 1.86 ENST00000564628.1
ENST00000563498.1
NME3
NME/NM23 nucleoside diphosphate kinase 3
chr5_+_175298573 1.82 ENST00000512824.1
CPLX2
complexin 2
chr16_-_1821721 1.75 ENST00000219302.3
NME3
NME/NM23 nucleoside diphosphate kinase 3
chr17_+_46970134 1.12 ENST00000503641.1
ENST00000514808.1
ATP5G1
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
chr9_-_130700080 0.89 ENST00000373110.4
DPM2
dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit
chr12_-_52715179 0.85 ENST00000293670.3
KRT83
keratin 83
chr2_-_74726710 0.81 ENST00000377566.4
LBX2
ladybird homeobox 2
chr5_+_133842243 0.75 ENST00000515627.2
AC005355.2
AC005355.2
chr12_+_53693466 0.70 ENST00000267103.5
ENST00000548632.1
C12orf10
chromosome 12 open reading frame 10
chrX_+_48380205 0.63 ENST00000446158.1
ENST00000414061.1
EBP
emopamil binding protein (sterol isomerase)
chr9_-_112970436 0.58 ENST00000400613.4
C9orf152
chromosome 9 open reading frame 152
chr12_-_56101647 0.57 ENST00000347027.6
ENST00000257879.6
ENST00000257880.7
ENST00000394230.2
ENST00000394229.2
ITGA7
integrin, alpha 7
chr2_+_219283815 0.56 ENST00000248444.5
ENST00000454069.1
ENST00000392114.2
VIL1
villin 1
chr19_-_42724261 0.52 ENST00000595337.1
DEDD2
death effector domain containing 2
chr17_+_46970178 0.51 ENST00000393366.2
ENST00000506855.1
ATP5G1
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
chr1_+_41157361 0.50 ENST00000427410.2
ENST00000447388.3
ENST00000425457.2
ENST00000453631.1
ENST00000456393.2
NFYC
nuclear transcription factor Y, gamma
chr17_-_29233221 0.47 ENST00000580840.1
TEFM
transcription elongation factor, mitochondrial
chr10_+_114135952 0.43 ENST00000356116.1
ENST00000433418.1
ENST00000354273.4
ACSL5
acyl-CoA synthetase long-chain family member 5
chr2_-_220173685 0.42 ENST00000423636.2
ENST00000442029.1
ENST00000412847.1
PTPRN
protein tyrosine phosphatase, receptor type, N
chr6_-_31869769 0.41 ENST00000375527.2
ZBTB12
zinc finger and BTB domain containing 12
chr1_+_41157671 0.37 ENST00000534399.1
ENST00000372653.1
NFYC
nuclear transcription factor Y, gamma
chr6_-_31509506 0.37 ENST00000449757.1
DDX39B
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
chr3_-_127541194 0.34 ENST00000453507.2
MGLL
monoglyceride lipase
chr12_-_6798523 0.32 ENST00000319770.3
ZNF384
zinc finger protein 384
chr1_+_41157421 0.32 ENST00000372654.1
NFYC
nuclear transcription factor Y, gamma
chr6_-_31509714 0.31 ENST00000456662.1
ENST00000431908.1
ENST00000456976.1
ENST00000428450.1
ENST00000453105.2
ENST00000418897.1
ENST00000415382.2
ENST00000449074.2
ENST00000419020.1
ENST00000428098.1
DDX39B
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
chr14_+_38660185 0.31 ENST00000555655.1
CTD-2142D14.1
CTD-2142D14.1
chr6_+_30749649 0.31 ENST00000422944.1
HCG20
HLA complex group 20 (non-protein coding)
chr16_-_28936007 0.30 ENST00000568703.1
ENST00000567483.1
RABEP2
rabaptin, RAB GTPase binding effector protein 2
chr14_-_24020858 0.30 ENST00000419474.3
ZFHX2
zinc finger homeobox 2
chr20_+_44650348 0.28 ENST00000454036.2
SLC12A5
solute carrier family 12 (potassium/chloride transporter), member 5
chr19_+_34745442 0.28 ENST00000299505.6
ENST00000588470.1
ENST00000589583.1
ENST00000588338.2
KIAA0355
KIAA0355
chrX_+_47077680 0.27 ENST00000522883.1
CDK16
cyclin-dependent kinase 16
chr6_-_31510181 0.25 ENST00000458640.1
ENST00000396172.1
ENST00000417556.2
DDX39B
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
chr6_-_32820529 0.25 ENST00000425148.2
TAP1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr10_-_103603568 0.24 ENST00000356640.2
KCNIP2
Kv channel interacting protein 2
chr1_+_155658849 0.23 ENST00000368336.5
ENST00000343043.3
ENST00000421487.2
ENST00000535183.1
ENST00000465375.1
ENST00000470830.1
DAP3
death associated protein 3
chr18_+_32558208 0.22 ENST00000436190.2
MAPRE2
microtubule-associated protein, RP/EB family, member 2
chr12_-_6798616 0.22 ENST00000355772.4
ENST00000417772.3
ENST00000396801.3
ENST00000396799.2
ZNF384
zinc finger protein 384
chr1_+_235491714 0.22 ENST00000471812.1
ENST00000358966.2
ENST00000282841.5
ENST00000391855.2
GGPS1
geranylgeranyl diphosphate synthase 1
chr10_-_103603523 0.22 ENST00000370046.1
KCNIP2
Kv channel interacting protein 2
chr17_-_29233769 0.21 ENST00000581216.1
TEFM
transcription elongation factor, mitochondrial
chr1_-_119530428 0.19 ENST00000369429.3
TBX15
T-box 15
chr7_-_102252038 0.19 ENST00000461209.1
RASA4
RAS p21 protein activator 4
chr5_-_141061777 0.18 ENST00000239440.4
ARAP3
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
chr17_+_46970127 0.18 ENST00000355938.5
ATP5G1
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
chr6_-_29395509 0.17 ENST00000377147.2
OR11A1
olfactory receptor, family 11, subfamily A, member 1
chr5_-_141061759 0.17 ENST00000508305.1
ARAP3
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
chrX_+_47077632 0.16 ENST00000457458.2
CDK16
cyclin-dependent kinase 16
chr14_-_102704783 0.16 ENST00000522534.1
MOK
MOK protein kinase
chr18_+_32558380 0.15 ENST00000588349.2
MAPRE2
microtubule-associated protein, RP/EB family, member 2
chr6_-_97285336 0.15 ENST00000229955.3
ENST00000417980.1
GPR63
G protein-coupled receptor 63
chr1_+_154975110 0.15 ENST00000535420.1
ENST00000368426.3
ZBTB7B
zinc finger and BTB domain containing 7B
chr13_-_64650144 0.15 ENST00000456627.1
LINC00355
long intergenic non-protein coding RNA 355
chr16_+_71560023 0.14 ENST00000572450.1
CHST4
carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4
chr18_-_33077556 0.14 ENST00000589273.1
ENST00000586489.1
INO80C
INO80 complex subunit C
chr20_+_44074071 0.13 ENST00000595203.1
AL031663.2
CDNA FLJ26875 fis, clone PRS08969; Uncharacterized protein
chr11_-_35440579 0.13 ENST00000606205.1
SLC1A2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr12_+_54955235 0.12 ENST00000550620.1
PDE1B
phosphodiesterase 1B, calmodulin-dependent
chr8_+_118147498 0.11 ENST00000519688.1
ENST00000456015.2
SLC30A8
solute carrier family 30 (zinc transporter), member 8
chrX_+_100333709 0.11 ENST00000372930.4
TMEM35
transmembrane protein 35
chr8_+_91233711 0.10 ENST00000523283.1
ENST00000517400.1
LINC00534
long intergenic non-protein coding RNA 534
chr8_-_133097902 0.10 ENST00000262283.5
OC90
Otoconin-90
chr7_+_155090271 0.09 ENST00000476756.1
INSIG1
insulin induced gene 1
chr11_+_4664650 0.09 ENST00000396952.5
OR51E1
olfactory receptor, family 51, subfamily E, member 1
chr16_+_31539183 0.09 ENST00000302312.4
AHSP
alpha hemoglobin stabilizing protein
chr17_-_17140436 0.08 ENST00000285071.4
ENST00000389169.5
ENST00000417064.1
FLCN
folliculin
chr1_+_248223984 0.08 ENST00000359959.3
OR2L3
olfactory receptor, family 2, subfamily L, member 3
chr12_-_6798410 0.08 ENST00000361959.3
ENST00000436774.2
ENST00000544482.1
ZNF384
zinc finger protein 384
chr8_-_93107443 0.08 ENST00000360348.2
ENST00000520428.1
ENST00000518992.1
ENST00000520556.1
ENST00000518317.1
ENST00000521319.1
ENST00000521375.1
ENST00000518449.1
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chrX_+_135230712 0.08 ENST00000535737.1
FHL1
four and a half LIM domains 1
chr1_-_155658260 0.07 ENST00000368339.5
ENST00000405763.3
ENST00000368340.5
ENST00000454523.1
ENST00000443231.1
ENST00000347088.5
ENST00000361831.5
ENST00000355499.4
YY1AP1
YY1 associated protein 1
chr8_+_91233750 0.07 ENST00000523406.1
LINC00534
long intergenic non-protein coding RNA 534
chr8_+_91233744 0.07 ENST00000524361.1
LINC00534
long intergenic non-protein coding RNA 534
chr1_+_248616077 0.06 ENST00000342927.3
OR2T2
olfactory receptor, family 2, subfamily T, member 2
chr6_+_167525277 0.06 ENST00000400926.2
CCR6
chemokine (C-C motif) receptor 6
chr1_-_155658518 0.06 ENST00000404643.1
ENST00000359205.5
ENST00000407221.1
YY1AP1
YY1 associated protein 1
chr11_-_125648690 0.06 ENST00000436890.2
ENST00000358524.3
PATE2
prostate and testis expressed 2
chr16_-_84651647 0.06 ENST00000564057.1
COTL1
coactosin-like 1 (Dictyostelium)
chr1_+_206317591 0.06 ENST00000432969.2
CTSE
cathepsin E
chr12_-_75601778 0.05 ENST00000550433.1
ENST00000548513.1
KCNC2
potassium voltage-gated channel, Shaw-related subfamily, member 2
chr1_+_145576007 0.05 ENST00000369298.1
PIAS3
protein inhibitor of activated STAT, 3
chr7_+_120969045 0.04 ENST00000222462.2
WNT16
wingless-type MMTV integration site family, member 16
chr3_-_164914640 0.04 ENST00000241274.3
SLITRK3
SLIT and NTRK-like family, member 3
chr1_-_161193349 0.04 ENST00000469730.2
ENST00000463273.1
ENST00000464492.1
ENST00000367990.3
ENST00000470459.2
ENST00000468465.1
ENST00000463812.1
APOA2
apolipoprotein A-II
chr2_-_188430478 0.04 ENST00000421427.1
TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr3_-_128186091 0.04 ENST00000319153.3
DNAJB8
DnaJ (Hsp40) homolog, subfamily B, member 8
chr13_-_54706954 0.03 ENST00000606706.1
ENST00000607494.1
ENST00000427299.2
ENST00000423442.2
ENST00000451744.1
LINC00458
long intergenic non-protein coding RNA 458
chr8_-_93107696 0.03 ENST00000436581.2
ENST00000520583.1
ENST00000519061.1
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr1_+_113263199 0.03 ENST00000361886.3
FAM19A3
family with sequence similarity 19 (chemokine (C-C motif)-like), member A3
chr8_-_93107827 0.03 ENST00000520724.1
ENST00000518844.1
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr6_-_29396243 0.02 ENST00000377148.1
OR11A1
olfactory receptor, family 11, subfamily A, member 1
chr1_+_162351503 0.01 ENST00000458626.2
C1orf226
chromosome 1 open reading frame 226
chr20_-_6034672 0.01 ENST00000378858.4
LRRN4
leucine rich repeat neuronal 4
chr1_-_248802559 0.01 ENST00000317450.3
OR2T35
olfactory receptor, family 2, subfamily T, member 35
chr1_+_155579979 0.01 ENST00000452804.2
ENST00000538143.1
ENST00000245564.2
ENST00000368341.4
MSTO1
misato 1, mitochondrial distribution and morphology regulator
chr1_-_155658085 0.01 ENST00000311573.5
ENST00000438245.2
YY1AP1
YY1 associated protein 1

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXB5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.9 GO:0042377 menaquinone catabolic process(GO:0042361) vitamin K catabolic process(GO:0042377)
0.2 3.6 GO:0006228 UTP biosynthetic process(GO:0006228)
0.2 3.7 GO:1901642 nucleoside transmembrane transport(GO:1901642)
0.1 0.9 GO:0019348 dolichol metabolic process(GO:0019348)
0.1 0.4 GO:1990502 dense core granule maturation(GO:1990502)
0.1 0.6 GO:0033489 cholesterol biosynthetic process via desmosterol(GO:0033489) cholesterol biosynthetic process via lathosterol(GO:0033490)
0.1 0.3 GO:0040040 thermosensory behavior(GO:0040040)
0.1 0.9 GO:2000002 negative regulation of DNA damage checkpoint(GO:2000002)
0.1 0.6 GO:1902896 terminal web assembly(GO:1902896)
0.1 0.7 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.1 0.2 GO:0033385 geranylgeranyl diphosphate metabolic process(GO:0033385) geranylgeranyl diphosphate biosynthetic process(GO:0033386)
0.1 0.5 GO:0045163 clustering of voltage-gated potassium channels(GO:0045163)
0.1 1.8 GO:0031915 positive regulation of synaptic plasticity(GO:0031915)
0.1 0.2 GO:0046967 cytosol to ER transport(GO:0046967)
0.1 1.8 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.0 0.3 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.0 0.1 GO:0043376 regulation of CD8-positive, alpha-beta T cell differentiation(GO:0043376)
0.0 0.3 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
0.0 0.7 GO:0035641 locomotory exploration behavior(GO:0035641)
0.0 0.1 GO:1901301 regulation of cargo loading into COPII-coated vesicle(GO:1901301)
0.0 0.5 GO:0016075 rRNA catabolic process(GO:0016075)
0.0 0.1 GO:2000506 negative regulation of energy homeostasis(GO:2000506)
0.0 0.1 GO:0060474 positive regulation of sperm motility involved in capacitation(GO:0060474)
0.0 1.2 GO:0045540 regulation of cholesterol biosynthetic process(GO:0045540)
0.0 0.0 GO:2000910 negative regulation of cholesterol import(GO:0060621) negative regulation of sterol import(GO:2000910)
0.0 0.1 GO:0070777 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0 0.1 GO:0006477 protein sulfation(GO:0006477)
0.0 0.4 GO:0030252 growth hormone secretion(GO:0030252)
0.0 0.4 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0033185 dolichol-phosphate-mannose synthase complex(GO:0033185)
0.2 1.8 GO:0070033 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033) synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554)
0.1 1.2 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.1 1.8 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1 0.9 GO:0005688 U6 snRNP(GO:0005688)
0.0 0.2 GO:0042825 TAP complex(GO:0042825)
0.0 0.2 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.0 0.6 GO:0032433 filopodium tip(GO:0032433)
0.0 0.1 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 3.7 GO:0008504 monoamine transmembrane transporter activity(GO:0008504)
0.2 0.9 GO:0004582 dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582)
0.2 0.7 GO:0030337 DNA polymerase processivity factor activity(GO:0030337)
0.2 0.6 GO:0004769 steroid delta-isomerase activity(GO:0004769)
0.1 3.6 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.1 0.9 GO:0030621 U4 snRNA binding(GO:0030621)
0.1 1.8 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.1 3.5 GO:0005504 fatty acid binding(GO:0005504)
0.1 0.5 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250) ER retention sequence binding(GO:0046923)
0.0 0.2 GO:0004161 dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337)
0.0 0.2 GO:0046979 TAP2 binding(GO:0046979)
0.0 1.8 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.3 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.0 0.3 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.1 GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517)
0.0 0.1 GO:0030492 hemoglobin binding(GO:0030492)
0.0 0.1 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.0 0.4 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.0 0.1 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.0 0.5 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.0 0.0 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 PID TRAIL PATHWAY TRAIL signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.8 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.1 3.7 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.1 0.9 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 0.8 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.4 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs