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SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for HOXD1

Z-value: 0.59

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Transcription factors associated with HOXD1

Gene Symbol Gene ID Gene Info
HOXD1
ENSG00000128645.11 homeobox D1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HOXD1hg19_v2_chr2_+_177053307_177053402-0.586.7e-03Click!

Activity profile of HOXD1 motif

Sorted Z-values of HOXD1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_-_151034734 2.52 ENST00000260843.4
GPR87
G protein-coupled receptor 87
chrX_+_43515467 2.34 ENST00000338702.3
ENST00000542639.1
MAOA
monoamine oxidase A
chr8_-_49834299 2.32 ENST00000396822.1
SNAI2
snail family zinc finger 2
chr8_-_49833978 2.14 ENST00000020945.1
SNAI2
snail family zinc finger 2
chr19_+_11071546 1.99 ENST00000358026.2
SMARCA4
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
chr11_-_102651343 1.82 ENST00000279441.4
ENST00000539681.1
MMP10
matrix metallopeptidase 10 (stromelysin 2)
chr11_+_65554493 1.67 ENST00000335987.3
OVOL1
ovo-like zinc finger 1
chr3_+_111717511 1.41 ENST00000478951.1
ENST00000393917.2
TAGLN3
transgelin 3
chr5_+_66300464 1.38 ENST00000436277.1
MAST4
microtubule associated serine/threonine kinase family member 4
chr11_+_71900703 1.37 ENST00000393681.2
FOLR1
folate receptor 1 (adult)
chr11_+_71900572 1.29 ENST00000312293.4
FOLR1
folate receptor 1 (adult)
chr4_-_74486217 1.24 ENST00000335049.5
ENST00000307439.5
RASSF6
Ras association (RalGDS/AF-6) domain family member 6
chr5_+_66300446 1.17 ENST00000261569.7
MAST4
microtubule associated serine/threonine kinase family member 4
chr3_+_111718036 1.16 ENST00000455401.2
TAGLN3
transgelin 3
chr4_+_144354644 1.08 ENST00000512843.1
GAB1
GRB2-associated binding protein 1
chr3_+_111717600 1.05 ENST00000273368.4
TAGLN3
transgelin 3
chr4_-_74486347 1.03 ENST00000342081.3
RASSF6
Ras association (RalGDS/AF-6) domain family member 6
chr4_-_74486109 1.01 ENST00000395777.2
RASSF6
Ras association (RalGDS/AF-6) domain family member 6
chr19_-_36001113 0.94 ENST00000434389.1
DMKN
dermokine
chr6_+_130339710 0.88 ENST00000526087.1
ENST00000533560.1
ENST00000361794.2
L3MBTL3
l(3)mbt-like 3 (Drosophila)
chr4_+_144312659 0.81 ENST00000509992.1
GAB1
GRB2-associated binding protein 1
chr9_+_124329336 0.81 ENST00000394340.3
ENST00000436835.1
ENST00000259371.2
DAB2IP
DAB2 interacting protein
chr3_-_99569821 0.78 ENST00000487087.1
FILIP1L
filamin A interacting protein 1-like
chr13_-_36050819 0.68 ENST00000379919.4
MAB21L1
mab-21-like 1 (C. elegans)
chr18_-_33709268 0.65 ENST00000269187.5
ENST00000590986.1
ENST00000440549.2
SLC39A6
solute carrier family 39 (zinc transporter), member 6
chr3_+_111718173 0.63 ENST00000494932.1
TAGLN3
transgelin 3
chr11_-_26593677 0.61 ENST00000527569.1
MUC15
mucin 15, cell surface associated
chr4_-_119759795 0.59 ENST00000419654.2
SEC24D
SEC24 family member D
chr1_+_117544366 0.58 ENST00000256652.4
ENST00000369470.1
CD101
CD101 molecule
chr11_-_26593779 0.57 ENST00000529533.1
MUC15
mucin 15, cell surface associated
chr12_-_22063787 0.55 ENST00000544039.1
ABCC9
ATP-binding cassette, sub-family C (CFTR/MRP), member 9
chr12_-_10022735 0.53 ENST00000228438.2
CLEC2B
C-type lectin domain family 2, member B
chr9_-_5339873 0.51 ENST00000223862.1
ENST00000223858.4
RLN1
relaxin 1
chr10_+_99205894 0.47 ENST00000370854.3
ENST00000393760.1
ENST00000414567.1
ENST00000370846.4
ZDHHC16
zinc finger, DHHC-type containing 16
chr4_-_25865159 0.44 ENST00000502949.1
ENST00000264868.5
ENST00000513691.1
ENST00000514872.1
SEL1L3
sel-1 suppressor of lin-12-like 3 (C. elegans)
chr11_-_26593649 0.40 ENST00000455601.2
MUC15
mucin 15, cell surface associated
chr5_+_67535647 0.38 ENST00000520675.1
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr14_+_32798462 0.38 ENST00000280979.4
AKAP6
A kinase (PRKA) anchor protein 6
chr2_+_191221240 0.37 ENST00000409027.1
ENST00000458193.1
INPP1
inositol polyphosphate-1-phosphatase
chr10_+_99205959 0.36 ENST00000352634.4
ENST00000353979.3
ENST00000370842.2
ENST00000345745.5
ZDHHC16
zinc finger, DHHC-type containing 16
chr14_+_57671888 0.33 ENST00000391612.1
AL391152.1
AL391152.1
chrX_+_107288280 0.33 ENST00000458383.1
VSIG1
V-set and immunoglobulin domain containing 1
chr5_+_148737562 0.32 ENST00000274569.4
PCYOX1L
prenylcysteine oxidase 1 like
chr16_+_53133070 0.31 ENST00000565832.1
CHD9
chromodomain helicase DNA binding protein 9
chr15_-_55562451 0.30 ENST00000568803.1
RAB27A
RAB27A, member RAS oncogene family
chr17_+_18086392 0.29 ENST00000541285.1
ALKBH5
alkB, alkylation repair homolog 5 (E. coli)
chr7_+_37723450 0.27 ENST00000447769.1
GPR141
G protein-coupled receptor 141
chr7_+_37723336 0.27 ENST00000450180.1
GPR141
G protein-coupled receptor 141
chr7_+_133812052 0.26 ENST00000285928.2
LRGUK
leucine-rich repeats and guanylate kinase domain containing
chr4_+_86749045 0.18 ENST00000514229.1
ARHGAP24
Rho GTPase activating protein 24
chr3_-_126327398 0.18 ENST00000383572.2
TXNRD3NB
thioredoxin reductase 3 neighbor
chr12_-_118797475 0.17 ENST00000541786.1
ENST00000419821.2
ENST00000541878.1
TAOK3
TAO kinase 3
chr4_-_69111401 0.15 ENST00000332644.5
TMPRSS11B
transmembrane protease, serine 11B
chr1_-_151431674 0.14 ENST00000531094.1
POGZ
pogo transposable element with ZNF domain
chrX_+_107288239 0.14 ENST00000217957.5
VSIG1
V-set and immunoglobulin domain containing 1
chr12_+_29376592 0.13 ENST00000182377.4
FAR2
fatty acyl CoA reductase 2
chr11_-_71823715 0.13 ENST00000545944.1
ENST00000502597.2
ANAPC15
anaphase promoting complex subunit 15
chr12_+_64798826 0.13 ENST00000540203.1
XPOT
exportin, tRNA
chr5_+_63802109 0.13 ENST00000334025.2
RGS7BP
regulator of G-protein signaling 7 binding protein
chr11_-_71823796 0.12 ENST00000545680.1
ENST00000543587.1
ENST00000538393.1
ENST00000535234.1
ENST00000227618.4
ENST00000535503.1
ANAPC15
anaphase promoting complex subunit 15
chr12_+_29376673 0.11 ENST00000547116.1
FAR2
fatty acyl CoA reductase 2
chr11_+_4615269 0.11 ENST00000530443.2
OR52I1
olfactory receptor, family 52, subfamily I, member 1
chr5_+_36606700 0.10 ENST00000416645.2
SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr4_+_86525299 0.10 ENST00000512201.1
ARHGAP24
Rho GTPase activating protein 24
chr11_-_62521614 0.09 ENST00000527994.1
ENST00000394807.3
ZBTB3
zinc finger and BTB domain containing 3
chr2_+_228736335 0.09 ENST00000440997.1
ENST00000545118.1
DAW1
dynein assembly factor with WDR repeat domains 1
chr22_-_24951888 0.09 ENST00000404664.3
GUCD1
guanylyl cyclase domain containing 1
chr11_+_4615037 0.08 ENST00000450052.2
OR52I1
olfactory receptor, family 52, subfamily I, member 1
chr14_+_32798547 0.07 ENST00000557354.1
ENST00000557102.1
ENST00000557272.1
AKAP6
A kinase (PRKA) anchor protein 6
chr7_-_81399329 0.07 ENST00000453411.1
ENST00000444829.2
HGF
hepatocyte growth factor (hepapoietin A; scatter factor)
chr1_-_151431647 0.07 ENST00000368863.2
ENST00000409503.1
ENST00000491586.1
ENST00000533351.1
ENST00000540984.1
POGZ
pogo transposable element with ZNF domain
chr7_-_81399355 0.06 ENST00000457544.2
HGF
hepatocyte growth factor (hepapoietin A; scatter factor)
chrX_+_107288197 0.06 ENST00000415430.3
VSIG1
V-set and immunoglobulin domain containing 1
chr5_+_176811431 0.06 ENST00000512593.1
ENST00000324417.5
SLC34A1
solute carrier family 34 (type II sodium/phosphate contransporter), member 1
chr11_-_18211042 0.05 ENST00000527671.1
RP11-113D6.6
Uncharacterized protein
chr10_-_4285923 0.05 ENST00000418372.1
ENST00000608792.1
LINC00702
long intergenic non-protein coding RNA 702
chr1_-_92952433 0.04 ENST00000294702.5
GFI1
growth factor independent 1 transcription repressor
chr4_-_139051839 0.04 ENST00000514600.1
ENST00000513895.1
ENST00000512536.1
LINC00616
long intergenic non-protein coding RNA 616
chr11_-_71823266 0.03 ENST00000538919.1
ENST00000539395.1
ENST00000542531.1
ANAPC15
anaphase promoting complex subunit 15
chr12_+_10163231 0.02 ENST00000396502.1
ENST00000338896.5
CLEC12B
C-type lectin domain family 12, member B
chr3_-_101039402 0.02 ENST00000193391.7
IMPG2
interphotoreceptor matrix proteoglycan 2
chr7_-_81399287 0.02 ENST00000354224.6
HGF
hepatocyte growth factor (hepapoietin A; scatter factor)
chr7_-_81399411 0.02 ENST00000423064.2
HGF
hepatocyte growth factor (hepapoietin A; scatter factor)
chr2_+_54350316 0.01 ENST00000606865.1
ACYP2
acylphosphatase 2, muscle type
chr12_+_15699286 0.01 ENST00000442921.2
ENST00000542557.1
ENST00000445537.2
ENST00000544244.1
PTPRO
protein tyrosine phosphatase, receptor type, O
chr10_-_4285835 0.01 ENST00000454470.1
LINC00702
long intergenic non-protein coding RNA 702
chr4_+_86748898 0.01 ENST00000509300.1
ARHGAP24
Rho GTPase activating protein 24
chr2_+_135596106 0.00 ENST00000356140.5
ACMSD
aminocarboxymuconate semialdehyde decarboxylase
chr4_-_150736962 0.00 ENST00000502345.1
ENST00000510975.1
ENST00000511993.1
RP11-526A4.1
RP11-526A4.1

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXD1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 4.5 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
0.9 2.7 GO:0061713 neural crest cell migration involved in heart formation(GO:0003147) anterior neural tube closure(GO:0061713)
0.4 1.7 GO:1901994 negative regulation of meiotic cell cycle phase transition(GO:1901994)
0.4 2.0 GO:0007070 negative regulation of transcription during mitosis(GO:0007068) negative regulation of transcription from RNA polymerase II promoter during mitosis(GO:0007070)
0.2 0.8 GO:0043553 vascular endothelial growth factor receptor-2 signaling pathway(GO:0036324) negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.1 2.3 GO:0042420 dopamine catabolic process(GO:0042420)
0.1 0.9 GO:1903575 cornified envelope assembly(GO:1903575)
0.1 0.3 GO:0030327 prenylated protein catabolic process(GO:0030327)
0.1 2.5 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.1 0.3 GO:0035553 oxidative RNA demethylation(GO:0035513) oxidative single-stranded RNA demethylation(GO:0035553)
0.1 0.4 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.1 0.9 GO:0043249 erythrocyte maturation(GO:0043249)
0.0 2.0 GO:0035728 response to hepatocyte growth factor(GO:0035728)
0.0 0.2 GO:0010025 wax biosynthetic process(GO:0010025) wax metabolic process(GO:0010166)
0.0 0.7 GO:0071578 zinc II ion transmembrane import(GO:0071578)
0.0 0.6 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.0 0.8 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.1 GO:0097187 dentinogenesis(GO:0097187) regulation of sodium-dependent phosphate transport(GO:2000118)
0.0 0.5 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.0 1.8 GO:0030574 collagen catabolic process(GO:0030574)
0.0 1.6 GO:0016266 O-glycan processing(GO:0016266)
0.0 0.4 GO:0051531 NFAT protein import into nucleus(GO:0051531) positive regulation of endoplasmic reticulum unfolded protein response(GO:1900103)
0.0 0.0 GO:0070105 regulation of interleukin-6-mediated signaling pathway(GO:0070103) positive regulation of interleukin-6-mediated signaling pathway(GO:0070105)
0.0 0.3 GO:1903504 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:1990032 parallel fiber(GO:1990032)
0.1 2.7 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.1 2.0 GO:0071564 npBAF complex(GO:0071564)
0.1 0.6 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.0 0.4 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
0.0 0.3 GO:0002177 manchette(GO:0002177)
0.0 0.4 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0 0.6 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.7 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 4.3 GO:0043209 myelin sheath(GO:0043209)
0.0 1.6 GO:0005796 Golgi lumen(GO:0005796)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.7 GO:0061714 folic acid receptor activity(GO:0061714)
0.3 2.3 GO:0008131 primary amine oxidase activity(GO:0008131)
0.1 0.6 GO:0008281 sulfonylurea receptor activity(GO:0008281)
0.1 0.8 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
0.1 2.0 GO:0030957 Tat protein binding(GO:0030957)
0.1 2.5 GO:0001608 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.1 0.4 GO:0052829 inositol-1,4-bisphosphate 1-phosphatase activity(GO:0004441) inositol-1,3,4-trisphosphate 1-phosphatase activity(GO:0052829)
0.1 0.6 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
0.1 0.3 GO:0035515 oxidative RNA demethylase activity(GO:0035515)
0.0 0.2 GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019)
0.0 0.3 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor(GO:0016670)
0.0 2.3 GO:0016303 1-phosphatidylinositol-3-kinase activity(GO:0016303)
0.0 6.2 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 0.4 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 0.8 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.7 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 1.8 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.1 GO:0015501 glutamate:sodium symporter activity(GO:0015501)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.0 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.1 6.8 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 0.8 PID RAS PATHWAY Regulation of Ras family activation

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.3 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.1 1.8 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 2.3 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR
0.0 1.6 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.7 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 0.6 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC