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SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for HSF1

Z-value: 0.50

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Transcription factors associated with HSF1

Gene Symbol Gene ID Gene Info
HSF1
ENSG00000185122.6 heat shock transcription factor 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HSF1hg19_v2_chr8_+_145515263_145515299-0.623.6e-03Click!

Activity profile of HSF1 motif

Sorted Z-values of HSF1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr12_-_52911718 2.24 ENST00000548409.1
KRT5
keratin 5
chr17_-_39661849 1.75 ENST00000246635.3
ENST00000336861.3
ENST00000587544.1
ENST00000587435.1
KRT13
keratin 13
chr16_+_56659687 1.30 ENST00000568293.1
ENST00000330439.6
MT1E
metallothionein 1E
chr1_-_153363452 1.22 ENST00000368732.1
ENST00000368733.3
S100A8
S100 calcium binding protein A8
chr17_-_39928106 1.22 ENST00000540235.1
JUP
junction plakoglobin
chr11_-_104840093 1.15 ENST00000417440.2
ENST00000444739.2
CASP4
caspase 4, apoptosis-related cysteine peptidase
chrX_-_73072534 1.14 ENST00000429829.1
XIST
X inactive specific transcript (non-protein coding)
chr17_-_39661947 1.14 ENST00000590425.1
KRT13
keratin 13
chr8_+_124194752 1.13 ENST00000318462.6
FAM83A
family with sequence similarity 83, member A
chr1_+_35247859 1.13 ENST00000373362.3
GJB3
gap junction protein, beta 3, 31kDa
chr2_+_237476419 0.99 ENST00000447924.1
ACKR3
atypical chemokine receptor 3
chr7_+_157129738 0.94 ENST00000437030.1
DNAJB6
DnaJ (Hsp40) homolog, subfamily B, member 6
chr17_-_39677971 0.91 ENST00000393976.2
KRT15
keratin 15
chr6_+_35265586 0.85 ENST00000542066.1
ENST00000316637.5
DEF6
differentially expressed in FDCP 6 homolog (mouse)
chr11_-_104905840 0.81 ENST00000526568.1
ENST00000393136.4
ENST00000531166.1
ENST00000534497.1
ENST00000527979.1
ENST00000446369.1
ENST00000353247.5
ENST00000528974.1
ENST00000533400.1
ENST00000525825.1
ENST00000436863.3
CASP1
caspase 1, apoptosis-related cysteine peptidase
chr6_+_47666275 0.79 ENST00000327753.3
ENST00000283303.2
GPR115
G protein-coupled receptor 115
chr19_-_36004543 0.75 ENST00000339686.3
ENST00000447113.2
ENST00000440396.1
DMKN
dermokine
chr2_+_113735575 0.74 ENST00000376489.2
ENST00000259205.4
IL36G
interleukin 36, gamma
chr19_-_51522955 0.71 ENST00000358789.3
KLK10
kallikrein-related peptidase 10
chr7_-_3083573 0.70 ENST00000396946.4
CARD11
caspase recruitment domain family, member 11
chr7_+_150020363 0.65 ENST00000359623.4
ENST00000493307.1
LRRC61
leucine rich repeat containing 61
chr2_-_56150910 0.64 ENST00000424836.2
ENST00000438672.1
ENST00000440439.1
ENST00000429909.1
ENST00000424207.1
ENST00000452337.1
ENST00000355426.3
ENST00000439193.1
ENST00000421664.1
EFEMP1
EGF containing fibulin-like extracellular matrix protein 1
chr11_+_123986069 0.64 ENST00000456829.2
ENST00000361352.5
ENST00000449321.1
ENST00000392748.1
ENST00000360334.4
ENST00000392744.4
VWA5A
von Willebrand factor A domain containing 5A
chr11_+_34645791 0.62 ENST00000529527.1
ENST00000531728.1
ENST00000525253.1
EHF
ets homologous factor
chr19_-_51456344 0.62 ENST00000336334.3
ENST00000593428.1
KLK5
kallikrein-related peptidase 5
chr18_+_21452804 0.60 ENST00000269217.6
LAMA3
laminin, alpha 3
chr19_-_53193731 0.59 ENST00000598536.1
ENST00000594682.2
ENST00000601257.1
ZNF83
zinc finger protein 83
chr19_-_12444306 0.59 ENST00000594577.1
ENST00000601858.1
ZNF563
zinc finger protein 563
chr14_+_24837226 0.58 ENST00000554050.1
ENST00000554903.1
ENST00000554779.1
ENST00000250373.4
ENST00000553708.1
NFATC4
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
chr19_-_51523412 0.57 ENST00000391805.1
ENST00000599077.1
KLK10
kallikrein-related peptidase 10
chr1_+_19970202 0.57 ENST00000439664.1
NBL1
neuroblastoma 1, DAN family BMP antagonist
chr14_-_24809154 0.57 ENST00000216274.5
RIPK3
receptor-interacting serine-threonine kinase 3
chr18_+_21452964 0.57 ENST00000587184.1
LAMA3
laminin, alpha 3
chr6_-_32784687 0.56 ENST00000447394.1
ENST00000438763.2
HLA-DOB
major histocompatibility complex, class II, DO beta
chr19_-_6720686 0.54 ENST00000245907.6
C3
complement component 3
chr6_-_170599561 0.54 ENST00000366756.3
DLL1
delta-like 1 (Drosophila)
chr4_-_77819002 0.53 ENST00000334306.2
SOWAHB
sosondowah ankyrin repeat domain family member B
chr16_-_79634595 0.53 ENST00000326043.4
ENST00000393350.1
MAF
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
chr6_+_46620676 0.52 ENST00000371347.5
ENST00000411689.2
SLC25A27
solute carrier family 25, member 27
chr7_+_150020329 0.51 ENST00000323078.7
LRRC61
leucine rich repeat containing 61
chr19_-_2051223 0.50 ENST00000309340.7
ENST00000589534.1
ENST00000250896.3
ENST00000589509.1
MKNK2
MAP kinase interacting serine/threonine kinase 2
chr19_-_51456198 0.50 ENST00000594846.1
KLK5
kallikrein-related peptidase 5
chr19_-_51523275 0.50 ENST00000309958.3
KLK10
kallikrein-related peptidase 10
chr4_+_106816644 0.49 ENST00000506666.1
ENST00000503451.1
NPNT
nephronectin
chr1_-_27682962 0.49 ENST00000486046.1
MAP3K6
mitogen-activated protein kinase kinase kinase 6
chr12_-_123011476 0.49 ENST00000528279.1
ENST00000344591.4
ENST00000526560.2
RSRC2
arginine/serine-rich coiled-coil 2
chrX_+_147062844 0.48 ENST00000370467.3
FMR1NB
fragile X mental retardation 1 neighbor
chr19_-_2085323 0.48 ENST00000591638.1
MOB3A
MOB kinase activator 3A
chr15_-_72490114 0.47 ENST00000309731.7
GRAMD2
GRAM domain containing 2
chr1_-_183538319 0.47 ENST00000420553.1
ENST00000419402.1
NCF2
neutrophil cytosolic factor 2
chr1_+_10003486 0.46 ENST00000403197.1
ENST00000377205.1
NMNAT1
nicotinamide nucleotide adenylyltransferase 1
chr1_+_161494036 0.45 ENST00000309758.4
HSPA6
heat shock 70kDa protein 6 (HSP70B')
chr11_-_111782696 0.44 ENST00000227251.3
ENST00000526180.1
CRYAB
crystallin, alpha B
chr17_+_8339340 0.44 ENST00000580012.1
NDEL1
nudE neurodevelopment protein 1-like 1
chr11_-_125773085 0.44 ENST00000227474.3
ENST00000534158.1
ENST00000529801.1
PUS3
pseudouridylate synthase 3
chr2_-_220142892 0.44 ENST00000427737.1
TUBA4A
tubulin, alpha 4a
chr2_-_241831424 0.44 ENST00000402775.2
ENST00000307486.8
C2orf54
chromosome 2 open reading frame 54
chr21_+_35445827 0.43 ENST00000608209.1
ENST00000381151.3
SLC5A3
SLC5A3
sodium/myo-inositol cotransporter
solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
chr2_+_47596287 0.41 ENST00000263735.4
EPCAM
epithelial cell adhesion molecule
chr11_+_10471836 0.41 ENST00000444303.2
AMPD3
adenosine monophosphate deaminase 3
chr20_-_62168714 0.40 ENST00000542869.1
PTK6
protein tyrosine kinase 6
chr6_-_38607628 0.40 ENST00000498633.1
BTBD9
BTB (POZ) domain containing 9
chr2_-_151395525 0.40 ENST00000439275.1
RND3
Rho family GTPase 3
chr19_+_8429031 0.40 ENST00000301455.2
ENST00000541807.1
ENST00000393962.2
ANGPTL4
angiopoietin-like 4
chr12_+_119772502 0.39 ENST00000536742.1
ENST00000327554.2
CCDC60
coiled-coil domain containing 60
chr3_+_44916098 0.39 ENST00000296125.4
TGM4
transglutaminase 4
chr21_+_39644172 0.39 ENST00000398932.1
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr6_+_46620705 0.39 ENST00000452689.2
SLC25A27
solute carrier family 25, member 27
chr22_-_36556821 0.38 ENST00000531095.1
ENST00000397293.2
ENST00000349314.2
APOL3
apolipoprotein L, 3
chr6_+_32937083 0.38 ENST00000456339.1
BRD2
bromodomain containing 2
chr19_-_10628117 0.38 ENST00000333430.4
S1PR5
sphingosine-1-phosphate receptor 5
chr9_+_71736177 0.38 ENST00000606364.1
ENST00000453658.2
TJP2
tight junction protein 2
chr14_+_101293687 0.37 ENST00000455286.1
MEG3
maternally expressed 3 (non-protein coding)
chr14_+_75988768 0.36 ENST00000286639.6
BATF
basic leucine zipper transcription factor, ATF-like
chr20_-_62168672 0.36 ENST00000217185.2
PTK6
protein tyrosine kinase 6
chr21_+_39644214 0.36 ENST00000438657.1
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr1_-_109584716 0.36 ENST00000531337.1
ENST00000529074.1
ENST00000369965.4
WDR47
WD repeat domain 47
chr17_+_4901199 0.36 ENST00000320785.5
ENST00000574165.1
KIF1C
kinesin family member 1C
chrX_+_37208540 0.35 ENST00000466533.1
ENST00000542554.1
ENST00000543642.1
ENST00000484460.1
ENST00000449135.2
ENST00000463135.1
ENST00000465127.1
PRRG1
TM4SF2
proline rich Gla (G-carboxyglutamic acid) 1
Uncharacterized protein; cDNA FLJ59144, highly similar to Tetraspanin-7
chr20_+_43803517 0.35 ENST00000243924.3
PI3
peptidase inhibitor 3, skin-derived
chr6_-_10419871 0.34 ENST00000319516.4
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr3_+_156393349 0.34 ENST00000473702.1
TIPARP
TCDD-inducible poly(ADP-ribose) polymerase
chr3_-_122233723 0.34 ENST00000493510.1
ENST00000344337.6
ENST00000476916.1
ENST00000465882.1
KPNA1
karyopherin alpha 1 (importin alpha 5)
chr19_-_14629224 0.34 ENST00000254322.2
DNAJB1
DnaJ (Hsp40) homolog, subfamily B, member 1
chr2_-_238499131 0.33 ENST00000538644.1
RAB17
RAB17, member RAS oncogene family
chr3_-_183735731 0.33 ENST00000334444.6
ABCC5
ATP-binding cassette, sub-family C (CFTR/MRP), member 5
chr3_+_38032216 0.33 ENST00000416303.1
VILL
villin-like
chr20_+_37230511 0.33 ENST00000373345.4
ARHGAP40
Rho GTPase activating protein 40
chr6_-_29648887 0.32 ENST00000376883.1
ZFP57
ZFP57 zinc finger protein
chr19_+_56905024 0.32 ENST00000591172.1
ENST00000589888.1
ENST00000587979.1
ENST00000585659.1
ENST00000593109.1
ZNF582-AS1
ZNF582 antisense RNA 1 (head to head)
chr12_-_10826612 0.32 ENST00000535345.1
ENST00000542562.1
STYK1
serine/threonine/tyrosine kinase 1
chr3_+_42977846 0.32 ENST00000383748.4
KRBOX1
KRAB box domain containing 1
chr22_-_38699003 0.32 ENST00000451964.1
CSNK1E
casein kinase 1, epsilon
chrX_-_7895755 0.31 ENST00000444736.1
ENST00000537427.1
ENST00000442940.1
PNPLA4
patatin-like phospholipase domain containing 4
chr1_-_109584768 0.31 ENST00000357672.3
WDR47
WD repeat domain 47
chr19_-_49567124 0.31 ENST00000301411.3
NTF4
neurotrophin 4
chr18_+_14748194 0.31 ENST00000358984.4
ANKRD30B
ankyrin repeat domain 30B
chr1_-_27709816 0.31 ENST00000374030.1
CD164L2
CD164 sialomucin-like 2
chr7_-_150020750 0.31 ENST00000539352.1
ACTR3C
ARP3 actin-related protein 3 homolog C (yeast)
chr14_+_71165292 0.30 ENST00000553682.1
RP6-65G23.1
RP6-65G23.1
chr1_-_116926718 0.30 ENST00000598661.1
AL136376.1
Uncharacterized protein
chr7_+_157129660 0.30 ENST00000429029.2
ENST00000262177.4
ENST00000417758.1
ENST00000452797.2
ENST00000443280.1
DNAJB6
DnaJ (Hsp40) homolog, subfamily B, member 6
chr19_-_2151523 0.30 ENST00000350812.6
ENST00000355272.6
ENST00000356926.4
ENST00000345016.5
AP3D1
adaptor-related protein complex 3, delta 1 subunit
chr14_-_21493123 0.29 ENST00000556147.1
ENST00000554489.1
ENST00000555657.1
ENST00000557274.1
ENST00000555158.1
ENST00000554833.1
ENST00000555384.1
ENST00000556420.1
ENST00000554893.1
ENST00000553503.1
ENST00000555733.1
ENST00000553867.1
ENST00000397856.3
ENST00000397855.3
ENST00000556008.1
ENST00000557182.1
ENST00000554483.1
ENST00000556688.1
ENST00000397853.3
ENST00000556329.2
ENST00000554143.1
ENST00000397851.2
ENST00000555142.1
ENST00000557676.1
ENST00000556924.1
NDRG2
NDRG family member 2
chr11_+_64323098 0.29 ENST00000301891.4
SLC22A11
solute carrier family 22 (organic anion/urate transporter), member 11
chr5_+_149887672 0.29 ENST00000261797.6
NDST1
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
chr21_+_42733870 0.29 ENST00000330714.3
ENST00000436410.1
ENST00000435611.1
MX2
myxovirus (influenza virus) resistance 2 (mouse)
chr9_+_470288 0.29 ENST00000382303.1
KANK1
KN motif and ankyrin repeat domains 1
chr12_-_47219733 0.29 ENST00000547477.1
ENST00000447411.1
ENST00000266579.4
SLC38A4
solute carrier family 38, member 4
chr11_+_33563821 0.28 ENST00000321505.4
ENST00000265654.5
ENST00000389726.3
KIAA1549L
KIAA1549-like
chrX_+_150866779 0.28 ENST00000370353.3
PRRG3
proline rich Gla (G-carboxyglutamic acid) 3 (transmembrane)
chr1_-_47082495 0.28 ENST00000545730.1
ENST00000531769.1
ENST00000319928.3
MKNK1
MOB3C
MAP kinase interacting serine/threonine kinase 1
MOB kinase activator 3C
chr8_-_8318847 0.28 ENST00000521218.1
CTA-398F10.2
CTA-398F10.2
chr2_-_9143786 0.28 ENST00000462696.1
ENST00000305997.3
MBOAT2
membrane bound O-acyltransferase domain containing 2
chr6_-_46620522 0.28 ENST00000275016.2
CYP39A1
cytochrome P450, family 39, subfamily A, polypeptide 1
chr7_-_150020814 0.28 ENST00000477871.1
ACTR3C
ARP3 actin-related protein 3 homolog C (yeast)
chr2_+_28718921 0.28 ENST00000327757.5
ENST00000422425.2
ENST00000404858.1
PLB1
phospholipase B1
chr20_-_18038521 0.27 ENST00000278780.6
OVOL2
ovo-like zinc finger 2
chr9_+_72658490 0.27 ENST00000377182.4
MAMDC2
MAM domain containing 2
chr4_+_57396766 0.27 ENST00000512175.2
THEGL
theg spermatid protein-like
chr11_+_65851443 0.27 ENST00000533756.1
PACS1
phosphofurin acidic cluster sorting protein 1
chr3_-_18487057 0.27 ENST00000415069.1
SATB1
SATB homeobox 1
chr4_+_119200215 0.26 ENST00000602573.1
SNHG8
small nucleolar RNA host gene 8 (non-protein coding)
chr4_+_166300084 0.26 ENST00000402744.4
CPE
carboxypeptidase E
chr19_-_14628234 0.26 ENST00000595139.1
DNAJB1
DnaJ (Hsp40) homolog, subfamily B, member 1
chr6_+_29910301 0.26 ENST00000376809.5
ENST00000376802.2
HLA-A
major histocompatibility complex, class I, A
chr10_+_24528108 0.26 ENST00000438429.1
KIAA1217
KIAA1217
chr12_-_10875831 0.26 ENST00000279550.7
ENST00000228251.4
YBX3
Y box binding protein 3
chr11_+_33563618 0.26 ENST00000526400.1
KIAA1549L
KIAA1549-like
chr10_-_90611566 0.26 ENST00000371930.4
ANKRD22
ankyrin repeat domain 22
chr11_-_111782484 0.26 ENST00000533971.1
CRYAB
crystallin, alpha B
chr20_+_58203664 0.26 ENST00000541461.1
PHACTR3
phosphatase and actin regulator 3
chr3_+_42947600 0.26 ENST00000328199.6
ENST00000541208.1
ZNF662
zinc finger protein 662
chr20_+_1875378 0.26 ENST00000356025.3
SIRPA
signal-regulatory protein alpha
chr7_-_139763521 0.25 ENST00000263549.3
PARP12
poly (ADP-ribose) polymerase family, member 12
chr10_+_15001430 0.25 ENST00000407572.1
MEIG1
meiosis/spermiogenesis associated 1
chr2_+_220144052 0.25 ENST00000425450.1
ENST00000392086.4
ENST00000421532.1
DNAJB2
DnaJ (Hsp40) homolog, subfamily B, member 2
chr17_-_43138357 0.25 ENST00000342350.5
DCAKD
dephospho-CoA kinase domain containing
chr11_-_914812 0.25 ENST00000533059.1
CHID1
chitinase domain containing 1
chr19_-_56904799 0.25 ENST00000589895.1
ENST00000589143.1
ENST00000301310.4
ENST00000586929.1
ZNF582
zinc finger protein 582
chr19_-_44952635 0.25 ENST00000592308.1
ENST00000588931.1
ENST00000291187.4
ZNF229
zinc finger protein 229
chr11_-_134123142 0.25 ENST00000392595.2
ENST00000341541.3
ENST00000352327.5
ENST00000392594.3
THYN1
thymocyte nuclear protein 1
chr18_-_32870148 0.25 ENST00000589178.1
ENST00000333206.5
ENST00000592278.1
ENST00000592211.1
ENST00000420878.3
ENST00000383091.2
ENST00000586922.2
ZSCAN30
RP11-158H5.7
zinc finger and SCAN domain containing 30
RP11-158H5.7
chr11_-_33744256 0.24 ENST00000415002.2
ENST00000437761.2
ENST00000445143.2
CD59
CD59 molecule, complement regulatory protein
chr13_-_79979919 0.24 ENST00000267229.7
RBM26
RNA binding motif protein 26
chr13_-_79979952 0.24 ENST00000438724.1
RBM26
RNA binding motif protein 26
chr19_-_12444519 0.24 ENST00000595977.1
ZNF563
zinc finger protein 563
chr2_+_220143989 0.24 ENST00000336576.5
DNAJB2
DnaJ (Hsp40) homolog, subfamily B, member 2
chr6_+_10521574 0.24 ENST00000495262.1
GCNT2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
chrX_+_37208521 0.24 ENST00000378628.4
PRRG1
proline rich Gla (G-carboxyglutamic acid) 1
chr3_-_59035673 0.24 ENST00000491845.1
ENST00000472469.1
ENST00000471288.1
ENST00000295966.7
C3orf67
chromosome 3 open reading frame 67
chr1_-_236030216 0.24 ENST00000389794.3
ENST00000389793.2
LYST
lysosomal trafficking regulator
chr11_-_88070896 0.24 ENST00000529974.1
ENST00000527018.1
CTSC
cathepsin C
chr12_-_123011536 0.24 ENST00000331738.7
ENST00000354654.2
RSRC2
arginine/serine-rich coiled-coil 2
chr9_+_109685630 0.23 ENST00000451160.2
RP11-508N12.4
Uncharacterized protein
chr1_-_27709793 0.23 ENST00000374027.3
ENST00000374025.3
CD164L2
CD164 sialomucin-like 2
chr1_+_152957707 0.23 ENST00000368762.1
SPRR1A
small proline-rich protein 1A
chr6_-_112081113 0.23 ENST00000517419.1
FYN
FYN oncogene related to SRC, FGR, YES
chr3_+_52720187 0.23 ENST00000474423.1
GNL3
guanine nucleotide binding protein-like 3 (nucleolar)
chr11_-_105010320 0.23 ENST00000532895.1
ENST00000530950.1
CARD18
caspase recruitment domain family, member 18
chrX_-_152939252 0.23 ENST00000340888.3
PNCK
pregnancy up-regulated nonubiquitous CaM kinase
chr2_+_220144168 0.23 ENST00000392087.2
ENST00000442681.1
ENST00000439026.1
DNAJB2
DnaJ (Hsp40) homolog, subfamily B, member 2
chr7_+_2393714 0.23 ENST00000431643.1
EIF3B
eukaryotic translation initiation factor 3, subunit B
chr22_+_41253080 0.23 ENST00000541156.1
ENST00000414396.1
ENST00000357137.4
XPNPEP3
X-prolyl aminopeptidase (aminopeptidase P) 3, putative
chr7_+_116451100 0.22 ENST00000464223.1
ENST00000484325.1
CAPZA2
capping protein (actin filament) muscle Z-line, alpha 2
chr6_-_116601044 0.22 ENST00000368608.3
TSPYL1
TSPY-like 1
chr9_+_19408999 0.22 ENST00000340967.2
ACER2
alkaline ceramidase 2
chr4_-_159644507 0.22 ENST00000307720.3
PPID
peptidylprolyl isomerase D
chr12_-_76425368 0.22 ENST00000602540.1
PHLDA1
pleckstrin homology-like domain, family A, member 1
chr6_-_38607673 0.22 ENST00000481247.1
BTBD9
BTB (POZ) domain containing 9
chr17_+_8339189 0.22 ENST00000585098.1
ENST00000380025.4
ENST00000402554.3
ENST00000584866.1
ENST00000582490.1
NDEL1
nudE neurodevelopment protein 1-like 1
chr6_-_131949200 0.22 ENST00000539158.1
ENST00000368058.1
MED23
mediator complex subunit 23
chr2_+_231577532 0.22 ENST00000258418.5
CAB39
calcium binding protein 39
chr19_+_3762703 0.22 ENST00000589174.1
MRPL54
mitochondrial ribosomal protein L54
chr13_-_79980315 0.22 ENST00000438737.2
RBM26
RNA binding motif protein 26
chr1_-_10856694 0.22 ENST00000377022.3
ENST00000344008.5
CASZ1
castor zinc finger 1
chr3_+_32433363 0.22 ENST00000465248.1
CMTM7
CKLF-like MARVEL transmembrane domain containing 7
chr6_-_160210604 0.21 ENST00000420894.2
ENST00000539756.1
ENST00000544255.1
TCP1
t-complex 1
chr1_-_149982624 0.21 ENST00000417191.1
ENST00000369135.4
OTUD7B
OTU domain containing 7B
chr7_+_70229899 0.21 ENST00000443672.1
AUTS2
autism susceptibility candidate 2
chr3_-_183735651 0.21 ENST00000427120.2
ENST00000392579.2
ENST00000382494.2
ENST00000446941.2
ABCC5
ATP-binding cassette, sub-family C (CFTR/MRP), member 5
chr1_-_201390846 0.21 ENST00000367312.1
ENST00000555340.2
ENST00000361379.4
TNNI1
troponin I type 1 (skeletal, slow)
chr4_+_90032651 0.21 ENST00000603357.1
RP11-84C13.1
RP11-84C13.1
chr5_-_171615315 0.21 ENST00000176763.5
STK10
serine/threonine kinase 10
chr6_+_32936353 0.21 ENST00000374825.4
BRD2
bromodomain containing 2
chr11_-_33744487 0.21 ENST00000426650.2
CD59
CD59 molecule, complement regulatory protein
chrX_-_152989499 0.21 ENST00000423827.1
BCAP31
B-cell receptor-associated protein 31
chr17_-_39928501 0.21 ENST00000420370.1
JUP
junction plakoglobin
chr2_+_85360499 0.21 ENST00000282111.3
TCF7L1
transcription factor 7-like 1 (T-cell specific, HMG-box)
chr1_-_68698197 0.21 ENST00000370973.2
ENST00000370971.1
WLS
wntless Wnt ligand secretion mediator
chr22_+_38453207 0.21 ENST00000404072.3
ENST00000424694.1
PICK1
protein interacting with PRKCA 1
chr5_+_14664762 0.21 ENST00000284274.4
FAM105B
family with sequence similarity 105, member B
chr1_+_47489240 0.20 ENST00000371901.3
CYP4X1
cytochrome P450, family 4, subfamily X, polypeptide 1
chr2_+_113816685 0.20 ENST00000393200.2
IL36RN
interleukin 36 receptor antagonist
chr3_-_195603566 0.20 ENST00000424563.1
ENST00000411741.1
TNK2
tyrosine kinase, non-receptor, 2
chrX_+_64887512 0.20 ENST00000360270.5
MSN
moesin
chr17_-_76123101 0.20 ENST00000392467.3
TMC6
transmembrane channel-like 6
chr9_+_123970052 0.20 ENST00000373823.3
GSN
gelsolin
chr21_-_46221684 0.20 ENST00000330942.5
UBE2G2
ubiquitin-conjugating enzyme E2G 2
chr22_+_29664241 0.20 ENST00000436425.1
ENST00000447973.1
EWSR1
EWS RNA-binding protein 1

Network of associatons between targets according to the STRING database.

First level regulatory network of HSF1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0051562 negative regulation of mitochondrial calcium ion concentration(GO:0051562)
0.2 1.0 GO:0050717 positive regulation of interleukin-1 alpha secretion(GO:0050717)
0.2 0.6 GO:0060545 positive regulation of necroptotic process(GO:0060545)
0.2 1.4 GO:0071603 endothelial cell-cell adhesion(GO:0071603)
0.2 0.6 GO:2000297 negative regulation of synapse maturation(GO:2000297)
0.2 0.6 GO:0002581 negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581)
0.2 1.1 GO:0002803 positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803)
0.2 0.5 GO:0002894 positive regulation of type IIa hypersensitivity(GO:0001798) positive regulation of type II hypersensitivity(GO:0002894)
0.2 0.5 GO:0048633 negative regulation of auditory receptor cell differentiation(GO:0045608) positive regulation of skeletal muscle tissue growth(GO:0048633)
0.2 0.5 GO:0097195 pilomotor reflex(GO:0097195)
0.1 0.7 GO:1903644 regulation of chaperone-mediated protein folding(GO:1903644)
0.1 2.5 GO:0043587 tongue morphogenesis(GO:0043587)
0.1 1.2 GO:0060715 syncytiotrophoblast cell differentiation involved in labyrinthine layer development(GO:0060715)
0.1 0.4 GO:0032707 negative regulation of interleukin-23 production(GO:0032707)
0.1 0.6 GO:0038098 sequestering of BMP from receptor via BMP binding(GO:0038098)
0.1 0.5 GO:0001971 negative regulation of activation of membrane attack complex(GO:0001971)
0.1 0.8 GO:1903575 cornified envelope assembly(GO:1903575)
0.1 0.3 GO:0002337 B-1a B cell differentiation(GO:0002337)
0.1 0.3 GO:0008052 sensory organ boundary specification(GO:0008052) formation of organ boundary(GO:0010160) taste bud development(GO:0061193)
0.1 0.4 GO:0042000 translocation of peptides or proteins into host(GO:0042000) translocation of peptides or proteins into host cell cytoplasm(GO:0044053) translocation of molecules into host(GO:0044417) translocation of peptides or proteins into other organism involved in symbiotic interaction(GO:0051808) translocation of molecules into other organism involved in symbiotic interaction(GO:0051836)
0.1 0.3 GO:0048003 synaptic vesicle recycling via endosome(GO:0036466) antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007)
0.1 0.3 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)
0.1 3.4 GO:0031581 hemidesmosome assembly(GO:0031581)
0.1 0.4 GO:1904000 positive regulation of eating behavior(GO:1904000)
0.1 0.4 GO:0070370 heat acclimation(GO:0010286) cellular heat acclimation(GO:0070370)
0.1 0.6 GO:1900242 regulation of synaptic vesicle endocytosis(GO:1900242)
0.1 0.6 GO:0032468 Golgi calcium ion homeostasis(GO:0032468)
0.1 0.3 GO:0030070 insulin processing(GO:0030070)
0.1 0.4 GO:0002415 immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415)
0.1 1.2 GO:0032119 sequestering of zinc ion(GO:0032119)
0.1 0.2 GO:0033364 mast cell secretory granule organization(GO:0033364)
0.1 0.5 GO:0019355 nicotinamide nucleotide biosynthetic process from aspartate(GO:0019355) 'de novo' NAD biosynthetic process from aspartate(GO:0034628)
0.1 0.2 GO:2000687 negative regulation of rubidium ion transport(GO:2000681) negative regulation of rubidium ion transmembrane transporter activity(GO:2000687)
0.1 0.6 GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265)
0.1 0.3 GO:0021557 optic cup structural organization(GO:0003409) oculomotor nerve development(GO:0021557) oculomotor nerve morphogenesis(GO:0021622) oculomotor nerve formation(GO:0021623)
0.1 0.2 GO:0040009 regulation of growth rate(GO:0040009)
0.1 0.4 GO:1990481 mRNA pseudouridine synthesis(GO:1990481)
0.1 0.2 GO:0006478 peptidyl-tyrosine sulfation(GO:0006478)
0.1 0.4 GO:0015798 myo-inositol transport(GO:0015798)
0.1 0.6 GO:0071492 cellular response to UV-A(GO:0071492)
0.1 0.4 GO:0006196 AMP catabolic process(GO:0006196)
0.1 0.2 GO:0006433 glutamyl-tRNA aminoacylation(GO:0006424) prolyl-tRNA aminoacylation(GO:0006433)
0.1 0.4 GO:1904154 positive regulation of retrograde protein transport, ER to cytosol(GO:1904154)
0.1 0.3 GO:0030573 bile acid catabolic process(GO:0030573)
0.1 0.7 GO:0060052 neurofilament cytoskeleton organization(GO:0060052)
0.1 0.4 GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
0.1 0.2 GO:0086054 atrial ventricular junction remodeling(GO:0003294) atrial cardiac muscle cell to AV node cell communication by electrical coupling(GO:0086044) bundle of His cell to Purkinje myocyte communication by electrical coupling(GO:0086054) Purkinje myocyte to ventricular cardiac muscle cell communication by electrical coupling(GO:0086055) regulation of Purkinje myocyte action potential(GO:0098906) vasomotion(GO:1990029)
0.1 0.2 GO:0098582 innate vocalization behavior(GO:0098582)
0.1 0.3 GO:0090285 negative regulation of protein glycosylation in Golgi(GO:0090285)
0.1 0.2 GO:0035750 protein localization to myelin sheath abaxonal region(GO:0035750)
0.1 0.2 GO:0061357 positive regulation of Wnt protein secretion(GO:0061357)
0.1 0.9 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.1 0.1 GO:0046086 adenosine biosynthetic process(GO:0046086)
0.0 0.2 GO:0001835 blastocyst hatching(GO:0001835) hatching(GO:0035188) organism emergence from protective structure(GO:0071684)
0.0 0.4 GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316)
0.0 0.1 GO:0032730 positive regulation of interleukin-1 alpha production(GO:0032730)
0.0 0.3 GO:0060214 endocardium formation(GO:0060214)
0.0 0.2 GO:0048294 negative regulation of isotype switching to IgE isotypes(GO:0048294)
0.0 0.7 GO:0070970 interleukin-2 secretion(GO:0070970)
0.0 0.1 GO:0031247 actin rod assembly(GO:0031247)
0.0 0.9 GO:0007021 tubulin complex assembly(GO:0007021)
0.0 0.2 GO:0022614 membrane to membrane docking(GO:0022614)
0.0 0.1 GO:0051466 corticotropin-releasing hormone secretion(GO:0043396) regulation of corticotropin-releasing hormone secretion(GO:0043397) positive regulation of corticotropin-releasing hormone secretion(GO:0051466)
0.0 0.2 GO:1903906 plasma membrane raft distribution(GO:0044855) plasma membrane raft localization(GO:0044856) plasma membrane raft polarization(GO:0044858) regulation of plasma membrane raft polarization(GO:1903906)
0.0 0.4 GO:0051005 negative regulation of lipoprotein lipase activity(GO:0051005)
0.0 0.4 GO:0071847 TNFSF11-mediated signaling pathway(GO:0071847)
0.0 0.1 GO:0006667 sphinganine metabolic process(GO:0006667)
0.0 0.2 GO:0044501 modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032)
0.0 1.2 GO:0071294 cellular response to zinc ion(GO:0071294)
0.0 0.2 GO:0036438 maintenance of lens transparency(GO:0036438)
0.0 0.1 GO:0045715 negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
0.0 0.1 GO:0045210 FasL biosynthetic process(GO:0045210)
0.0 0.2 GO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947)
0.0 0.2 GO:1902766 skeletal muscle satellite cell migration(GO:1902766)
0.0 0.0 GO:0002886 regulation of myeloid leukocyte mediated immunity(GO:0002886)
0.0 0.2 GO:0072660 maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.0 0.1 GO:0070676 intralumenal vesicle formation(GO:0070676)
0.0 0.3 GO:0051533 positive regulation of NFAT protein import into nucleus(GO:0051533)
0.0 0.1 GO:0035720 intraciliary anterograde transport(GO:0035720)
0.0 0.3 GO:0006477 protein sulfation(GO:0006477)
0.0 0.2 GO:0097411 hypoxia-inducible factor-1alpha signaling pathway(GO:0097411)
0.0 0.1 GO:0035606 peptidyl-cysteine S-trans-nitrosylation(GO:0035606)
0.0 0.1 GO:0072308 negative regulation by virus of viral protein levels in host cell(GO:0046725) negative regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072308)
0.0 0.1 GO:0019082 viral protein processing(GO:0019082) regulation of nerve growth factor production(GO:0032903) negative regulation of nerve growth factor production(GO:0032904) dibasic protein processing(GO:0090472)
0.0 0.1 GO:0098972 dendritic transport of mitochondrion(GO:0098939) anterograde dendritic transport of mitochondrion(GO:0098972)
0.0 0.2 GO:0035234 ectopic germ cell programmed cell death(GO:0035234)
0.0 0.1 GO:1900226 negative regulation of NLRP3 inflammasome complex assembly(GO:1900226)
0.0 0.2 GO:0032907 transforming growth factor beta3 production(GO:0032907) regulation of transforming growth factor beta3 production(GO:0032910) positive regulation of transforming growth factor beta3 production(GO:0032916) negative regulation of lung blood pressure(GO:0061767)
0.0 0.0 GO:0046668 regulation of retinal cell programmed cell death(GO:0046668)
0.0 0.3 GO:0015747 urate transport(GO:0015747)
0.0 0.3 GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480)
0.0 0.2 GO:1902714 negative regulation of interferon-gamma secretion(GO:1902714)
0.0 0.8 GO:0060575 intestinal epithelial cell differentiation(GO:0060575)
0.0 0.3 GO:0035799 ureter maturation(GO:0035799)
0.0 0.3 GO:2000580 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.0 0.1 GO:0097212 lysosomal membrane organization(GO:0097212) negative regulation of hydrogen peroxide catabolic process(GO:2000296) regulation of oxygen metabolic process(GO:2000374)
0.0 0.1 GO:0046947 hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947)
0.0 0.3 GO:1902219 negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902219)
0.0 0.1 GO:0015855 pyrimidine nucleobase transport(GO:0015855) purine nucleobase transmembrane transport(GO:1904823)
0.0 0.1 GO:0035880 embryonic nail plate morphogenesis(GO:0035880)
0.0 0.1 GO:1904383 response to sodium phosphate(GO:1904383)
0.0 0.2 GO:0075525 viral translational termination-reinitiation(GO:0075525)
0.0 0.4 GO:0030213 hyaluronan biosynthetic process(GO:0030213)
0.0 0.2 GO:0030263 apoptotic chromosome condensation(GO:0030263)
0.0 0.0 GO:1904349 regulation of small intestine smooth muscle contraction(GO:1904347) positive regulation of small intestine smooth muscle contraction(GO:1904349) small intestine smooth muscle contraction(GO:1990770)
0.0 0.1 GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway(GO:0040037)
0.0 0.2 GO:0048050 post-embryonic eye morphogenesis(GO:0048050)
0.0 0.1 GO:0038178 complement component C5a signaling pathway(GO:0038178)
0.0 0.1 GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining(GO:2001034)
0.0 0.2 GO:2000781 positive regulation of double-strand break repair(GO:2000781)
0.0 0.2 GO:0070131 positive regulation of mitochondrial translation(GO:0070131)
0.0 0.1 GO:1901907 diadenosine polyphosphate catabolic process(GO:0015961) diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
0.0 0.3 GO:0033235 positive regulation of protein sumoylation(GO:0033235)
0.0 0.2 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.0 0.2 GO:0050713 negative regulation of interleukin-1 beta secretion(GO:0050713)
0.0 0.1 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.0 0.1 GO:0043686 co-translational protein modification(GO:0043686)
0.0 0.1 GO:1901526 positive regulation of macromitophagy(GO:1901526) positive regulation of mitophagy in response to mitochondrial depolarization(GO:1904925)
0.0 0.2 GO:0002349 histamine production involved in inflammatory response(GO:0002349) histamine secretion involved in inflammatory response(GO:0002441) histamine secretion by mast cell(GO:0002553)
0.0 0.3 GO:0090360 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
0.0 0.1 GO:0010710 regulation of collagen catabolic process(GO:0010710)
0.0 0.1 GO:0000711 meiotic DNA repair synthesis(GO:0000711)
0.0 0.2 GO:0002084 protein depalmitoylation(GO:0002084)
0.0 0.1 GO:0031642 negative regulation of myelination(GO:0031642)
0.0 0.2 GO:0070862 negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153)
0.0 0.1 GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0 0.1 GO:0050689 negative regulation of defense response to virus by host(GO:0050689)
0.0 0.2 GO:1902951 negative regulation of dendritic spine maintenance(GO:1902951)
0.0 0.1 GO:0050712 negative regulation of interleukin-1 alpha production(GO:0032690) negative regulation of interleukin-1 alpha secretion(GO:0050712)
0.0 0.0 GO:2000619 negative regulation of histone H4-K16 acetylation(GO:2000619)
0.0 0.2 GO:0032057 negative regulation of translational initiation in response to stress(GO:0032057)
0.0 0.2 GO:2000271 positive regulation of fibroblast apoptotic process(GO:2000271)
0.0 0.7 GO:0070306 lens fiber cell differentiation(GO:0070306)
0.0 0.1 GO:0002296 T-helper 1 cell lineage commitment(GO:0002296)
0.0 0.0 GO:0006579 amino-acid betaine catabolic process(GO:0006579)
0.0 1.0 GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902230)
0.0 0.3 GO:0003373 dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374)
0.0 0.1 GO:0040032 post-embryonic body morphogenesis(GO:0040032)
0.0 0.1 GO:0019236 response to pheromone(GO:0019236)
0.0 0.1 GO:1903300 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.0 0.1 GO:0045085 negative regulation of interleukin-2 biosynthetic process(GO:0045085)
0.0 0.4 GO:0043373 T-helper cell lineage commitment(GO:0002295) CD4-positive, alpha-beta T cell lineage commitment(GO:0043373) T-helper 17 cell lineage commitment(GO:0072540)
0.0 0.8 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.0 0.0 GO:0016256 N-glycan processing to lysosome(GO:0016256)
0.0 0.0 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
0.0 0.2 GO:0002051 osteoblast fate commitment(GO:0002051)
0.0 0.1 GO:1900535 medium-chain fatty-acyl-CoA catabolic process(GO:0036114) long-chain fatty-acyl-CoA catabolic process(GO:0036116) palmitic acid metabolic process(GO:1900533) palmitic acid biosynthetic process(GO:1900535)
0.0 0.1 GO:0071374 cellular response to parathyroid hormone stimulus(GO:0071374)
0.0 0.2 GO:0009249 protein lipoylation(GO:0009249)
0.0 0.0 GO:0002305 gamma-delta intraepithelial T cell differentiation(GO:0002304) CD8-positive, gamma-delta intraepithelial T cell differentiation(GO:0002305)
0.0 0.4 GO:0019054 modulation by virus of host process(GO:0019054)
0.0 0.1 GO:0001951 intestinal D-glucose absorption(GO:0001951)
0.0 0.4 GO:0007620 copulation(GO:0007620)
0.0 0.1 GO:0051413 response to cortisone(GO:0051413)
0.0 0.1 GO:2001013 epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013)
0.0 0.1 GO:0048254 snoRNA localization(GO:0048254)
0.0 0.2 GO:0007258 JUN phosphorylation(GO:0007258)
0.0 0.0 GO:1903660 negative regulation of complement-dependent cytotoxicity(GO:1903660)
0.0 0.2 GO:0001778 plasma membrane repair(GO:0001778)
0.0 0.5 GO:0036151 phosphatidylcholine acyl-chain remodeling(GO:0036151)
0.0 0.1 GO:0046085 adenosine metabolic process(GO:0046085)
0.0 0.1 GO:0060992 response to fungicide(GO:0060992)
0.0 0.1 GO:0071286 cellular response to magnesium ion(GO:0071286)
0.0 0.3 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0 0.0 GO:0002232 leukocyte chemotaxis involved in inflammatory response(GO:0002232)
0.0 0.8 GO:0010107 potassium ion import(GO:0010107)
0.0 0.4 GO:0045730 respiratory burst(GO:0045730)
0.0 0.0 GO:0061386 closure of optic fissure(GO:0061386)
0.0 0.1 GO:0032482 Rab protein signal transduction(GO:0032482)
0.0 0.2 GO:0046951 ketone body biosynthetic process(GO:0046951)
0.0 0.1 GO:0098881 exocytic insertion of neurotransmitter receptor to plasma membrane(GO:0098881) exocytic insertion of neurotransmitter receptor to postsynaptic membrane(GO:0098967)
0.0 0.1 GO:0045084 positive regulation of interleukin-12 biosynthetic process(GO:0045084)
0.0 0.1 GO:0032790 ribosome disassembly(GO:0032790)
0.0 1.1 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.0 0.3 GO:2000052 positive regulation of non-canonical Wnt signaling pathway(GO:2000052)
0.0 0.2 GO:0033227 dsRNA transport(GO:0033227)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.4 GO:0071665 gamma-catenin-TCF7L2 complex(GO:0071665)
0.2 2.1 GO:0097169 AIM2 inflammasome complex(GO:0097169)
0.2 1.1 GO:0097209 epidermal lamellar body(GO:0097209)
0.1 0.7 GO:0060053 neurofilament cytoskeleton(GO:0060053)
0.1 0.4 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.1 1.2 GO:0005610 laminin-5 complex(GO:0005610)
0.1 0.6 GO:0034678 integrin alpha8-beta1 complex(GO:0034678)
0.1 0.4 GO:0005784 Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.1 4.7 GO:0045095 keratin filament(GO:0045095)
0.0 0.9 GO:0097512 cardiac myofibril(GO:0097512)
0.0 1.3 GO:0005922 connexon complex(GO:0005922)
0.0 0.5 GO:0032010 phagolysosome(GO:0032010)
0.0 0.2 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.0 0.9 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 0.1 GO:0071062 alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.0 0.2 GO:0070436 Grb2-EGFR complex(GO:0070436)
0.0 0.8 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 0.2 GO:0097452 GAIT complex(GO:0097452)
0.0 0.1 GO:1990796 photoreceptor cell terminal bouton(GO:1990796)
0.0 0.6 GO:0097342 ripoptosome(GO:0097342)
0.0 0.2 GO:0070545 PeBoW complex(GO:0070545)
0.0 0.4 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.0 0.3 GO:0042611 MHC protein complex(GO:0042611)
0.0 0.2 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.0 0.2 GO:0005851 eukaryotic translation initiation factor 2B complex(GO:0005851)
0.0 0.7 GO:0042101 T cell receptor complex(GO:0042101)
0.0 0.3 GO:0002199 zona pellucida receptor complex(GO:0002199)
0.0 0.2 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.0 0.1 GO:0035339 SPOTS complex(GO:0035339)
0.0 0.1 GO:0097450 astrocyte end-foot(GO:0097450)
0.0 0.2 GO:0061574 ASAP complex(GO:0061574)
0.0 0.5 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 0.1 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.0 0.2 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.0 0.2 GO:0036128 CatSper complex(GO:0036128)
0.0 0.2 GO:0030478 actin cap(GO:0030478)
0.0 0.1 GO:0031417 NatC complex(GO:0031417)
0.0 0.1 GO:0071546 pi-body(GO:0071546)
0.0 2.1 GO:0045111 intermediate filament cytoskeleton(GO:0045111)
0.0 0.2 GO:0008290 F-actin capping protein complex(GO:0008290)
0.0 0.7 GO:0001533 cornified envelope(GO:0001533)
0.0 0.7 GO:0008180 COP9 signalosome(GO:0008180)
0.0 0.2 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.0 0.2 GO:0031931 TORC1 complex(GO:0031931)
0.0 0.1 GO:0005921 gap junction(GO:0005921)
0.0 0.0 GO:0001534 radial spoke(GO:0001534)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.4 GO:0005199 structural constituent of cell wall(GO:0005199)
0.2 1.2 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
0.2 0.7 GO:0070012 oligopeptidase activity(GO:0070012)
0.1 0.4 GO:0005365 myo-inositol transmembrane transporter activity(GO:0005365)
0.1 0.6 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.1 0.6 GO:0050253 retinyl-palmitate esterase activity(GO:0050253)
0.1 2.9 GO:0050700 CARD domain binding(GO:0050700)
0.1 0.3 GO:0071633 dihydroceramidase activity(GO:0071633)
0.1 0.5 GO:0000309 nicotinamide-nucleotide adenylyltransferase activity(GO:0000309)
0.1 1.4 GO:0005243 gap junction channel activity(GO:0005243)
0.1 0.2 GO:0001156 TFIIIC-class transcription factor binding(GO:0001156)
0.1 0.2 GO:0008476 protein-tyrosine sulfotransferase activity(GO:0008476)
0.1 1.1 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.1 0.2 GO:0004827 glutamate-tRNA ligase activity(GO:0004818) proline-tRNA ligase activity(GO:0004827)
0.1 0.6 GO:0004704 NF-kappaB-inducing kinase activity(GO:0004704)
0.1 0.2 GO:0009383 rRNA (cytosine-C5-)-methyltransferase activity(GO:0009383)
0.1 0.9 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
0.1 0.2 GO:0016608 growth hormone-releasing hormone activity(GO:0016608) ghrelin receptor binding(GO:0031768)
0.1 0.6 GO:0016015 morphogen activity(GO:0016015)
0.1 0.9 GO:0032395 MHC class II receptor activity(GO:0032395)
0.1 2.5 GO:0001671 ATPase activator activity(GO:0001671)
0.0 0.2 GO:0003858 3-hydroxybutyrate dehydrogenase activity(GO:0003858)
0.0 0.6 GO:0030280 structural constituent of epidermis(GO:0030280)
0.0 0.1 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)
0.0 0.3 GO:0005166 neurotrophin p75 receptor binding(GO:0005166)
0.0 0.2 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0 0.3 GO:0050119 N-acetylglucosamine deacetylase activity(GO:0050119)
0.0 0.4 GO:0047623 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0 0.1 GO:0050146 nucleoside phosphotransferase activity(GO:0050146)
0.0 0.2 GO:0005152 interleukin-1 receptor antagonist activity(GO:0005152)
0.0 0.4 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.0 0.1 GO:0004618 phosphoglycerate kinase activity(GO:0004618)
0.0 0.9 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.1 GO:0015389 pyrimidine- and adenine-specific:sodium symporter activity(GO:0015389)
0.0 0.2 GO:0023024 MHC class I protein complex binding(GO:0023024)
0.0 0.2 GO:0032564 adenyl deoxyribonucleotide binding(GO:0032558) dATP binding(GO:0032564)
0.0 0.7 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.0 0.2 GO:0050659 N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity(GO:0050659)
0.0 0.1 GO:0030272 5-formyltetrahydrofolate cyclo-ligase activity(GO:0030272)
0.0 0.2 GO:0052836 inositol 5-diphosphate pentakisphosphate 5-kinase activity(GO:0052836) inositol diphosphate tetrakisphosphate kinase activity(GO:0052839)
0.0 3.7 GO:0097110 scaffold protein binding(GO:0097110)
0.0 0.8 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 0.1 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.0 0.8 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 0.1 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.0 0.3 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.0 0.5 GO:0043225 anion transmembrane-transporting ATPase activity(GO:0043225)
0.0 0.4 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 0.2 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.4 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.0 0.2 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0 0.4 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.0 0.2 GO:0031962 mineralocorticoid receptor binding(GO:0031962)
0.0 0.3 GO:1901702 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.0 0.5 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0 0.3 GO:0019960 C-X3-C chemokine binding(GO:0019960)
0.0 0.2 GO:0042610 CD8 receptor binding(GO:0042610)
0.0 0.2 GO:0051032 nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
0.0 0.1 GO:0033823 procollagen-lysine 5-dioxygenase activity(GO:0008475) procollagen glucosyltransferase activity(GO:0033823) procollagen galactosyltransferase activity(GO:0050211)
0.0 0.1 GO:0047676 arachidonate-CoA ligase activity(GO:0047676)
0.0 0.4 GO:0016018 cyclosporin A binding(GO:0016018)
0.0 0.4 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.0 0.1 GO:0004140 dephospho-CoA kinase activity(GO:0004140)
0.0 0.1 GO:0004878 complement component C5a receptor activity(GO:0004878)
0.0 0.3 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.0 0.3 GO:0008525 phosphatidylcholine transporter activity(GO:0008525)
0.0 0.2 GO:0008172 S-methyltransferase activity(GO:0008172)
0.0 0.1 GO:0000298 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432) inositol diphosphate tetrakisphosphate diphosphatase activity(GO:0052840) inositol bisdiphosphate tetrakisphosphate diphosphatase activity(GO:0052841) inositol diphosphate pentakisphosphate diphosphatase activity(GO:0052842) inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity(GO:0052843) inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity(GO:0052844) inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity(GO:0052845) inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity(GO:0052846) inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity(GO:0052847) inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity(GO:0052848)
0.0 0.1 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0 0.3 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.0 0.3 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.0 0.6 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.2 GO:0003696 satellite DNA binding(GO:0003696)
0.0 0.1 GO:0046790 virion binding(GO:0046790)
0.0 0.3 GO:0001758 retinal dehydrogenase activity(GO:0001758)
0.0 0.2 GO:0004705 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 0.1 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.0 0.1 GO:0008241 peptidyl-dipeptidase activity(GO:0008241)
0.0 0.0 GO:0003870 5-aminolevulinate synthase activity(GO:0003870) N-succinyltransferase activity(GO:0016749)
0.0 0.2 GO:0031404 chloride ion binding(GO:0031404)
0.0 0.0 GO:0004366 glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.0 0.1 GO:0016402 pristanoyl-CoA oxidase activity(GO:0016402)
0.0 0.2 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.0 0.1 GO:0043891 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.0 0.0 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.0 0.1 GO:0016454 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0 0.7 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.3 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.2 GO:0045159 myosin II binding(GO:0045159)
0.0 0.2 GO:0098599 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 0.1 GO:0004910 interleukin-1, Type II, blocking receptor activity(GO:0004910)
0.0 0.5 GO:0001848 complement binding(GO:0001848)
0.0 3.8 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.5 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.0 GO:0017082 mineralocorticoid receptor activity(GO:0017082)
0.0 1.3 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.1 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.0 0.1 GO:0050544 arachidonic acid binding(GO:0050544)
0.0 0.0 GO:0031728 CCR3 chemokine receptor binding(GO:0031728)
0.0 0.0 GO:0046997 oxidoreductase activity, acting on the CH-NH group of donors, flavin as acceptor(GO:0046997)
0.0 0.1 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.0 0.3 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.0 0.0 GO:0003976 UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976)
0.0 0.0 GO:0046538 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.0 0.1 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
0.0 0.1 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.0 0.1 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.2 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 1.9 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.0 2.4 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.8 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.0 1.3 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events
0.0 0.7 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 0.9 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 0.3 PID S1P S1P4 PATHWAY S1P4 pathway
0.0 1.1 PID CD8 TCR PATHWAY TCR signaling in naïve CD8+ T cells
0.0 0.8 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.0 0.4 PID IL27 PATHWAY IL27-mediated signaling events
0.0 0.3 ST INTERLEUKIN 4 PATHWAY Interleukin 4 (IL-4) Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.1 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.1 1.3 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.0 0.8 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 0.5 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 1.6 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.5 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.5 REACTOME INITIAL TRIGGERING OF COMPLEMENT Genes involved in Initial triggering of complement
0.0 1.2 REACTOME DOWNSTREAM TCR SIGNALING Genes involved in Downstream TCR signaling
0.0 0.4 REACTOME TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX Genes involved in TRAF6 mediated induction of TAK1 complex
0.0 0.4 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.3 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.0 0.5 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.0 0.4 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
0.0 0.5 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.0 0.4 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 0.2 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.0 1.0 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.0 0.3 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 0.3 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
0.0 0.6 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.0 1.0 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 0.7 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.3 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
0.0 1.5 REACTOME CELL JUNCTION ORGANIZATION Genes involved in Cell junction organization
0.0 0.2 REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.0 0.1 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR