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SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for HSF4

Z-value: 0.90

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Transcription factors associated with HSF4

Gene Symbol Gene ID Gene Info
HSF4
ENSG00000102878.11 heat shock transcription factor 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HSF4hg19_v2_chr16_+_67198683_67198715-0.785.7e-05Click!

Activity profile of HSF4 motif

Sorted Z-values of HSF4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr11_-_122932730 2.06 ENST00000532182.1
ENST00000524590.1
ENST00000528292.1
ENST00000533540.1
ENST00000525463.1
HSPA8
heat shock 70kDa protein 8
chr7_+_157129738 1.74 ENST00000437030.1
DNAJB6
DnaJ (Hsp40) homolog, subfamily B, member 6
chr11_-_122933043 1.66 ENST00000534624.1
ENST00000453788.2
ENST00000527387.1
HSPA8
heat shock 70kDa protein 8
chr13_-_31736132 1.55 ENST00000429785.2
HSPH1
heat shock 105kDa/110kDa protein 1
chr1_+_161494036 1.46 ENST00000309758.4
HSPA6
heat shock 70kDa protein 6 (HSP70B')
chr3_+_136676851 1.44 ENST00000309741.5
IL20RB
interleukin 20 receptor beta
chr3_+_136676707 1.36 ENST00000329582.4
IL20RB
interleukin 20 receptor beta
chr13_-_31736478 1.31 ENST00000445273.2
HSPH1
heat shock 105kDa/110kDa protein 1
chr17_-_39928106 1.25 ENST00000540235.1
JUP
junction plakoglobin
chr13_-_31736027 1.24 ENST00000380406.5
ENST00000320027.5
ENST00000380405.4
HSPH1
heat shock 105kDa/110kDa protein 1
chrX_-_73072534 1.18 ENST00000429829.1
XIST
X inactive specific transcript (non-protein coding)
chr2_+_201171268 1.12 ENST00000423749.1
ENST00000428692.1
ENST00000457757.1
ENST00000453663.1
SPATS2L
spermatogenesis associated, serine-rich 2-like
chr18_+_11751466 1.10 ENST00000535121.1
GNAL
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
chr14_-_102553371 1.04 ENST00000553585.1
ENST00000216281.8
HSP90AA1
heat shock protein 90kDa alpha (cytosolic), class A member 1
chr18_+_11751493 0.94 ENST00000269162.5
GNAL
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
chr19_-_14628645 0.87 ENST00000598235.1
DNAJB1
DnaJ (Hsp40) homolog, subfamily B, member 1
chr2_+_201171064 0.86 ENST00000451764.2
SPATS2L
spermatogenesis associated, serine-rich 2-like
chr17_+_44701402 0.82 ENST00000575068.1
NSF
N-ethylmaleimide-sensitive factor
chr22_-_41252962 0.80 ENST00000216218.3
ST13
suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
chr17_-_40168698 0.80 ENST00000590774.1
DNAJC7
DnaJ (Hsp40) homolog, subfamily C, member 7
chr14_+_72052983 0.79 ENST00000358550.2
SIPA1L1
signal-induced proliferation-associated 1 like 1
chr8_+_37594185 0.78 ENST00000518586.1
ENST00000335171.6
ENST00000521644.1
ERLIN2
ER lipid raft associated 2
chr2_+_201170999 0.77 ENST00000439395.1
ENST00000444012.1
SPATS2L
spermatogenesis associated, serine-rich 2-like
chr19_-_14628234 0.77 ENST00000595139.1
DNAJB1
DnaJ (Hsp40) homolog, subfamily B, member 1
chr12_-_123011476 0.77 ENST00000528279.1
ENST00000344591.4
ENST00000526560.2
RSRC2
arginine/serine-rich coiled-coil 2
chr7_-_3083573 0.77 ENST00000396946.4
CARD11
caspase recruitment domain family, member 11
chr2_-_198364581 0.76 ENST00000428204.1
HSPD1
heat shock 60kDa protein 1 (chaperonin)
chr3_+_186501979 0.75 ENST00000498746.1
EIF4A2
eukaryotic translation initiation factor 4A2
chr22_+_41253080 0.75 ENST00000541156.1
ENST00000414396.1
ENST00000357137.4
XPNPEP3
X-prolyl aminopeptidase (aminopeptidase P) 3, putative
chr2_+_201170770 0.73 ENST00000409988.3
ENST00000409385.1
SPATS2L
spermatogenesis associated, serine-rich 2-like
chr15_+_79165222 0.73 ENST00000559930.1
MORF4L1
mortality factor 4 like 1
chr4_-_159644507 0.71 ENST00000307720.3
PPID
peptidylprolyl isomerase D
chr6_-_106773291 0.70 ENST00000343245.3
ATG5
autophagy related 5
chr12_+_70132632 0.70 ENST00000378815.6
ENST00000483530.2
ENST00000325555.9
RAB3IP
RAB3A interacting protein
chr11_+_10772847 0.69 ENST00000524523.1
CTR9
CTR9, Paf1/RNA polymerase II complex component
chr12_-_76817036 0.66 ENST00000546946.1
OSBPL8
oxysterol binding protein-like 8
chr3_+_101443476 0.64 ENST00000327230.4
ENST00000494050.1
CEP97
centrosomal protein 97kDa
chr21_-_40720974 0.63 ENST00000380748.1
HMGN1
high mobility group nucleosome binding domain 1
chr21_-_40720995 0.63 ENST00000380749.5
HMGN1
high mobility group nucleosome binding domain 1
chrX_+_123094672 0.61 ENST00000354548.5
ENST00000458700.1
STAG2
stromal antigen 2
chr19_-_2085323 0.60 ENST00000591638.1
MOB3A
MOB kinase activator 3A
chr2_-_220142892 0.60 ENST00000427737.1
TUBA4A
tubulin, alpha 4a
chr17_-_62308087 0.60 ENST00000583097.1
TEX2
testis expressed 2
chr7_+_56119323 0.59 ENST00000275603.4
ENST00000335503.3
ENST00000540286.1
CCT6A
chaperonin containing TCP1, subunit 6A (zeta 1)
chr2_+_210444142 0.58 ENST00000360351.4
ENST00000361559.4
MAP2
microtubule-associated protein 2
chr11_+_67007518 0.58 ENST00000530342.1
ENST00000308783.5
KDM2A
lysine (K)-specific demethylase 2A
chr8_+_37594130 0.57 ENST00000518526.1
ENST00000523887.1
ENST00000276461.5
ERLIN2
ER lipid raft associated 2
chr19_-_49567124 0.57 ENST00000301411.3
NTF4
neurotrophin 4
chr9_+_34989638 0.57 ENST00000453597.3
ENST00000335998.3
ENST00000312316.5
DNAJB5
DnaJ (Hsp40) homolog, subfamily B, member 5
chr1_-_156307992 0.56 ENST00000415548.1
CCT3
chaperonin containing TCP1, subunit 3 (gamma)
chr3_+_130613226 0.56 ENST00000509662.1
ENST00000328560.8
ENST00000428331.2
ENST00000359644.3
ENST00000422190.2
ATP2C1
ATPase, Ca++ transporting, type 2C, member 1
chr2_+_210443993 0.56 ENST00000392193.1
MAP2
microtubule-associated protein 2
chr2_+_201171242 0.56 ENST00000360760.5
SPATS2L
spermatogenesis associated, serine-rich 2-like
chr9_-_86322831 0.55 ENST00000257468.7
UBQLN1
ubiquilin 1
chr1_-_245026388 0.55 ENST00000440865.1
HNRNPU
heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
chr12_-_48500085 0.55 ENST00000549518.1
SENP1
SUMO1/sentrin specific peptidase 1
chr11_-_89956461 0.54 ENST00000320585.6
CHORDC1
cysteine and histidine-rich domain (CHORD) containing 1
chr12_+_41136144 0.54 ENST00000548005.1
ENST00000552248.1
CNTN1
contactin 1
chr11_-_82997420 0.53 ENST00000455220.2
ENST00000529689.1
CCDC90B
coiled-coil domain containing 90B
chr1_+_17516275 0.53 ENST00000412427.1
RP11-380J14.1
RP11-380J14.1
chr4_-_152147579 0.53 ENST00000304527.4
ENST00000455740.1
ENST00000424281.1
ENST00000409598.4
SH3D19
SH3 domain containing 19
chrX_+_108779870 0.53 ENST00000372107.1
NXT2
nuclear transport factor 2-like export factor 2
chr2_+_201171577 0.52 ENST00000409397.2
SPATS2L
spermatogenesis associated, serine-rich 2-like
chr13_+_95254085 0.52 ENST00000376958.4
GPR180
G protein-coupled receptor 180
chr1_-_183538319 0.52 ENST00000420553.1
ENST00000419402.1
NCF2
neutrophil cytosolic factor 2
chr17_-_39928501 0.52 ENST00000420370.1
JUP
junction plakoglobin
chr6_+_44215603 0.51 ENST00000371554.1
HSP90AB1
heat shock protein 90kDa alpha (cytosolic), class B member 1
chr7_+_157129660 0.51 ENST00000429029.2
ENST00000262177.4
ENST00000417758.1
ENST00000452797.2
ENST00000443280.1
DNAJB6
DnaJ (Hsp40) homolog, subfamily B, member 6
chr11_+_65266507 0.50 ENST00000544868.1
MALAT1
metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)
chr6_+_36165133 0.50 ENST00000446974.1
ENST00000454960.1
BRPF3
bromodomain and PHD finger containing, 3
chr21_+_35445827 0.49 ENST00000608209.1
ENST00000381151.3
SLC5A3
SLC5A3
sodium/myo-inositol cotransporter
solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
chr11_-_89956227 0.49 ENST00000457199.2
ENST00000530765.1
CHORDC1
cysteine and histidine-rich domain (CHORD) containing 1
chrX_+_150866779 0.49 ENST00000370353.3
PRRG3
proline rich Gla (G-carboxyglutamic acid) 3 (transmembrane)
chr11_+_193065 0.48 ENST00000342878.2
SCGB1C1
secretoglobin, family 1C, member 1
chr11_+_63953587 0.48 ENST00000305218.4
ENST00000538945.1
STIP1
stress-induced-phosphoprotein 1
chr3_+_130613001 0.47 ENST00000504948.1
ENST00000513801.1
ENST00000505072.1
ATP2C1
ATPase, Ca++ transporting, type 2C, member 1
chr19_-_4717835 0.47 ENST00000599248.1
DPP9
dipeptidyl-peptidase 9
chr13_+_31191920 0.47 ENST00000255304.4
USPL1
ubiquitin specific peptidase like 1
chr11_+_63953691 0.47 ENST00000543847.1
STIP1
stress-induced-phosphoprotein 1
chr15_+_96869165 0.47 ENST00000421109.2
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr2_+_201171372 0.46 ENST00000409140.3
SPATS2L
spermatogenesis associated, serine-rich 2-like
chr21_+_44394742 0.46 ENST00000432907.2
PKNOX1
PBX/knotted 1 homeobox 1
chr22_+_17082732 0.46 ENST00000558085.2
ENST00000592918.1
ENST00000400593.2
ENST00000592107.1
ENST00000426585.1
ENST00000591299.1
TPTEP1
transmembrane phosphatase with tensin homology pseudogene 1
chrX_+_123094369 0.46 ENST00000455404.1
ENST00000218089.9
STAG2
stromal antigen 2
chr11_-_134123142 0.45 ENST00000392595.2
ENST00000341541.3
ENST00000352327.5
ENST00000392594.3
THYN1
thymocyte nuclear protein 1
chr19_-_49565254 0.45 ENST00000593537.1
NTF4
neurotrophin 4
chr19_+_1354930 0.45 ENST00000591337.1
MUM1
melanoma associated antigen (mutated) 1
chr13_-_41593425 0.44 ENST00000239882.3
ELF1
E74-like factor 1 (ets domain transcription factor)
chr11_-_82997371 0.44 ENST00000525503.1
CCDC90B
coiled-coil domain containing 90B
chr1_-_27709793 0.44 ENST00000374027.3
ENST00000374025.3
CD164L2
CD164 sialomucin-like 2
chr3_-_183735651 0.44 ENST00000427120.2
ENST00000392579.2
ENST00000382494.2
ENST00000446941.2
ABCC5
ATP-binding cassette, sub-family C (CFTR/MRP), member 5
chr21_+_39668478 0.43 ENST00000398927.1
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr12_+_2904102 0.43 ENST00000001008.4
FKBP4
FK506 binding protein 4, 59kDa
chrX_+_108780062 0.43 ENST00000372106.1
NXT2
nuclear transport factor 2-like export factor 2
chr7_+_26240776 0.43 ENST00000337620.4
CBX3
chromobox homolog 3
chr1_+_27158505 0.43 ENST00000534643.1
ZDHHC18
zinc finger, DHHC-type containing 18
chr3_-_183735731 0.43 ENST00000334444.6
ABCC5
ATP-binding cassette, sub-family C (CFTR/MRP), member 5
chr6_-_138833630 0.42 ENST00000533765.1
NHSL1
NHS-like 1
chr9_-_6015607 0.41 ENST00000259569.5
RANBP6
RAN binding protein 6
chr18_+_57567180 0.40 ENST00000316660.6
ENST00000269518.9
PMAIP1
phorbol-12-myristate-13-acetate-induced protein 1
chr22_+_32871224 0.40 ENST00000452138.1
ENST00000382058.3
ENST00000397426.1
FBXO7
F-box protein 7
chrX_-_43741594 0.40 ENST00000536181.1
ENST00000378069.4
MAOB
monoamine oxidase B
chr12_-_110939870 0.40 ENST00000447578.2
ENST00000546588.1
ENST00000360579.7
ENST00000549970.1
ENST00000549578.1
VPS29
vacuolar protein sorting 29 homolog (S. cerevisiae)
chr1_-_27709816 0.39 ENST00000374030.1
CD164L2
CD164 sialomucin-like 2
chr4_-_25865159 0.39 ENST00000502949.1
ENST00000264868.5
ENST00000513691.1
ENST00000514872.1
SEL1L3
sel-1 suppressor of lin-12-like 3 (C. elegans)
chr1_+_27158483 0.38 ENST00000374141.2
ZDHHC18
zinc finger, DHHC-type containing 18
chr20_-_43589109 0.37 ENST00000372813.3
TOMM34
translocase of outer mitochondrial membrane 34
chr16_+_57139933 0.37 ENST00000566259.1
CPNE2
copine II
chr18_-_6929829 0.36 ENST00000583840.1
ENST00000581571.1
ENST00000578497.1
ENST00000579012.1
LINC00668
long intergenic non-protein coding RNA 668
chr17_+_7258442 0.36 ENST00000389982.4
ENST00000576060.1
ENST00000330767.4
TMEM95
transmembrane protein 95
chr3_+_130612803 0.36 ENST00000510168.1
ENST00000508532.1
ATP2C1
ATPase, Ca++ transporting, type 2C, member 1
chr14_-_68141535 0.35 ENST00000554659.1
VTI1B
vesicle transport through interaction with t-SNAREs 1B
chr20_+_4666882 0.35 ENST00000379440.4
ENST00000430350.2
PRNP
prion protein
chr20_+_36149602 0.34 ENST00000062104.2
ENST00000346199.2
NNAT
neuronatin
chr12_+_70132458 0.34 ENST00000247833.7
RAB3IP
RAB3A interacting protein
chr2_+_210444298 0.34 ENST00000445941.1
MAP2
microtubule-associated protein 2
chr12_-_57030096 0.34 ENST00000549506.1
BAZ2A
bromodomain adjacent to zinc finger domain, 2A
chr17_-_8286484 0.33 ENST00000582556.1
ENST00000584164.1
ENST00000293842.5
ENST00000584343.1
ENST00000578812.1
ENST00000583011.1
RPL26
ribosomal protein L26
chr20_+_55108302 0.33 ENST00000371325.1
FAM209B
family with sequence similarity 209, member B
chr2_+_201170703 0.33 ENST00000358677.5
SPATS2L
spermatogenesis associated, serine-rich 2-like
chr6_+_4890226 0.32 ENST00000343762.5
CDYL
chromodomain protein, Y-like
chr15_+_79165112 0.31 ENST00000426013.2
MORF4L1
mortality factor 4 like 1
chr15_+_41952591 0.29 ENST00000566718.1
ENST00000219905.7
ENST00000389936.4
ENST00000545763.1
MGA
MGA, MAX dimerization protein
chr9_-_86323118 0.29 ENST00000376395.4
UBQLN1
ubiquilin 1
chr11_-_47870019 0.29 ENST00000378460.2
NUP160
nucleoporin 160kDa
chr20_+_57430162 0.28 ENST00000450130.1
ENST00000349036.3
ENST00000423897.1
GNAS
GNAS complex locus
chr9_-_13279406 0.27 ENST00000546205.1
MPDZ
multiple PDZ domain protein
chr4_-_40632881 0.27 ENST00000511598.1
RBM47
RNA binding motif protein 47
chr5_+_10250328 0.27 ENST00000515390.1
CCT5
chaperonin containing TCP1, subunit 5 (epsilon)
chr11_-_47869865 0.27 ENST00000530326.1
ENST00000532747.1
NUP160
nucleoporin 160kDa
chr4_-_40632757 0.27 ENST00000511902.1
ENST00000505220.1
RBM47
RNA binding motif protein 47
chr8_+_143781513 0.26 ENST00000292430.6
ENST00000561179.1
ENST00000518841.1
ENST00000519387.1
LY6K
lymphocyte antigen 6 complex, locus K
chr8_-_81083618 0.26 ENST00000520795.1
TPD52
tumor protein D52
chr14_-_23388338 0.26 ENST00000555209.1
ENST00000554256.1
ENST00000557403.1
ENST00000557549.1
ENST00000555676.1
ENST00000557571.1
ENST00000557464.1
ENST00000554618.1
ENST00000556862.1
ENST00000555722.1
ENST00000346528.5
ENST00000542016.2
ENST00000399922.2
ENST00000557227.1
ENST00000359890.3
RBM23
RNA binding motif protein 23
chr19_-_14629224 0.26 ENST00000254322.2
DNAJB1
DnaJ (Hsp40) homolog, subfamily B, member 1
chr3_+_183899770 0.26 ENST00000442686.1
AP2M1
adaptor-related protein complex 2, mu 1 subunit
chr4_-_22517620 0.25 ENST00000502482.1
ENST00000334304.5
GPR125
G protein-coupled receptor 125
chr12_-_110883346 0.25 ENST00000547365.1
ARPC3
actin related protein 2/3 complex, subunit 3, 21kDa
chr6_-_41168920 0.25 ENST00000483722.1
TREML2
triggering receptor expressed on myeloid cells-like 2
chr2_-_25100893 0.25 ENST00000433852.1
ADCY3
adenylate cyclase 3
chr19_-_51893827 0.25 ENST00000574814.1
CTD-2616J11.4
chromosome 19 open reading frame 84
chr1_-_26232522 0.25 ENST00000399728.1
STMN1
stathmin 1
chr10_-_62332357 0.24 ENST00000503366.1
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr11_-_111794446 0.24 ENST00000527950.1
CRYAB
crystallin, alpha B
chr4_-_17513604 0.24 ENST00000505710.1
QDPR
quinoid dihydropteridine reductase
chr3_-_185655795 0.24 ENST00000342294.4
ENST00000382191.4
ENST00000453386.2
TRA2B
transformer 2 beta homolog (Drosophila)
chrX_-_102942961 0.24 ENST00000434230.1
ENST00000418819.1
ENST00000360458.1
MORF4L2
mortality factor 4 like 2
chr2_-_238499303 0.23 ENST00000409576.1
RAB17
RAB17, member RAS oncogene family
chr12_-_108154925 0.23 ENST00000228437.5
PRDM4
PR domain containing 4
chr11_-_111781554 0.23 ENST00000526167.1
ENST00000528961.1
CRYAB
crystallin, alpha B
chr1_-_173638976 0.23 ENST00000333279.2
ANKRD45
ankyrin repeat domain 45
chrX_-_128782722 0.23 ENST00000427399.1
APLN
apelin
chr13_-_31191642 0.22 ENST00000405805.1
HMGB1
high mobility group box 1
chr2_-_238499131 0.22 ENST00000538644.1
RAB17
RAB17, member RAS oncogene family
chr2_+_203130439 0.22 ENST00000264279.5
NOP58
NOP58 ribonucleoprotein
chrX_+_123095155 0.22 ENST00000371160.1
ENST00000435103.1
STAG2
stromal antigen 2
chr13_-_20805109 0.21 ENST00000241124.6
GJB6
gap junction protein, beta 6, 30kDa
chr1_-_152386732 0.21 ENST00000271835.3
CRNN
cornulin
chr12_-_123011536 0.21 ENST00000331738.7
ENST00000354654.2
RSRC2
arginine/serine-rich coiled-coil 2
chr6_+_42531798 0.21 ENST00000372903.2
ENST00000372899.1
ENST00000372901.1
UBR2
ubiquitin protein ligase E3 component n-recognin 2
chr11_-_914812 0.21 ENST00000533059.1
CHID1
chitinase domain containing 1
chr1_+_144811744 0.21 ENST00000338347.4
ENST00000440491.2
ENST00000375552.4
NBPF9
neuroblastoma breakpoint family, member 9
chr1_+_28586006 0.21 ENST00000253063.3
SESN2
sestrin 2
chrX_-_80377162 0.21 ENST00000430960.1
ENST00000447319.1
HMGN5
high mobility group nucleosome binding domain 5
chr1_-_149459549 0.20 ENST00000369175.3
FAM72C
family with sequence similarity 72, member C
chr17_-_61850894 0.19 ENST00000403162.3
ENST00000582252.1
ENST00000225726.5
CCDC47
coiled-coil domain containing 47
chrX_-_102943022 0.19 ENST00000433176.2
MORF4L2
mortality factor 4 like 2
chr12_+_50794891 0.19 ENST00000517559.1
LARP4
La ribonucleoprotein domain family, member 4
chr9_+_109685630 0.18 ENST00000451160.2
RP11-508N12.4
Uncharacterized protein
chr7_-_100493744 0.18 ENST00000428317.1
ENST00000441605.1
ACHE
acetylcholinesterase (Yt blood group)
chr20_+_58203664 0.18 ENST00000541461.1
PHACTR3
phosphatase and actin regulator 3
chr10_+_24528108 0.18 ENST00000438429.1
KIAA1217
KIAA1217
chr19_-_51893782 0.17 ENST00000570516.1
CTD-2616J11.4
chromosome 19 open reading frame 84
chr20_+_10015678 0.17 ENST00000378392.1
ENST00000378380.3
ANKEF1
ankyrin repeat and EF-hand domain containing 1
chr16_+_68119764 0.17 ENST00000570212.1
ENST00000562926.1
NFATC3
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
chr14_-_81425828 0.17 ENST00000555529.1
ENST00000556042.1
ENST00000556981.1
CEP128
centrosomal protein 128kDa
chrX_-_55515635 0.16 ENST00000500968.3
USP51
ubiquitin specific peptidase 51
chr6_+_160693591 0.16 ENST00000419196.1
RP1-276N6.2
RP1-276N6.2
chr8_+_140943416 0.16 ENST00000507535.3
C8orf17
chromosome 8 open reading frame 17
chr7_-_1199781 0.16 ENST00000397083.1
ENST00000401903.1
ENST00000316495.3
ZFAND2A
zinc finger, AN1-type domain 2A
chr9_+_123970052 0.16 ENST00000373823.3
GSN
gelsolin
chr12_-_4754339 0.16 ENST00000228850.1
AKAP3
A kinase (PRKA) anchor protein 3
chr1_+_154947126 0.15 ENST00000368439.1
CKS1B
CDC28 protein kinase regulatory subunit 1B
chr12_-_4754356 0.15 ENST00000540967.1
AKAP3
A kinase (PRKA) anchor protein 3
chr1_-_6453426 0.14 ENST00000545482.1
ACOT7
acyl-CoA thioesterase 7
chrX_-_152939133 0.14 ENST00000370150.1
PNCK
pregnancy up-regulated nonubiquitous CaM kinase
chr2_-_62115659 0.14 ENST00000544185.1
CCT4
chaperonin containing TCP1, subunit 4 (delta)
chr1_+_27248203 0.14 ENST00000321265.5
NUDC
nudC nuclear distribution protein
chr18_+_9136758 0.14 ENST00000383440.2
ENST00000262126.4
ENST00000577992.1
ANKRD12
ankyrin repeat domain 12
chr22_+_29168652 0.14 ENST00000249064.4
ENST00000444523.1
ENST00000448492.2
ENST00000421503.2
CCDC117
coiled-coil domain containing 117
chr22_+_29664248 0.13 ENST00000406548.1
ENST00000437155.2
ENST00000415761.1
ENST00000331029.7
EWSR1
EWS RNA-binding protein 1
chr11_+_107799118 0.13 ENST00000320578.2
RAB39A
RAB39A, member RAS oncogene family
chr21_-_30445886 0.13 ENST00000431234.1
ENST00000540844.1
ENST00000286788.4
CCT8
chaperonin containing TCP1, subunit 8 (theta)
chr19_+_41509851 0.13 ENST00000593831.1
ENST00000330446.5
CYP2B6
cytochrome P450, family 2, subfamily B, polypeptide 6
chr3_+_186501336 0.13 ENST00000323963.5
ENST00000440191.2
ENST00000356531.5
EIF4A2
eukaryotic translation initiation factor 4A2
chr11_+_20385666 0.13 ENST00000532081.1
ENST00000531058.1
HTATIP2
HIV-1 Tat interactive protein 2, 30kDa
chr15_+_79165151 0.13 ENST00000331268.5
MORF4L1
mortality factor 4 like 1
chr5_-_133706695 0.12 ENST00000521755.1
ENST00000523054.1
ENST00000435240.2
ENST00000609654.1
ENST00000536186.1
ENST00000609383.1
CDKL3
cyclin-dependent kinase-like 3
chr11_+_65769946 0.12 ENST00000533166.1
BANF1
barrier to autointegration factor 1
chr12_+_65563329 0.12 ENST00000308330.2
LEMD3
LEM domain containing 3

Network of associatons between targets according to the STRING database.

First level regulatory network of HSF4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 3.7 GO:1904764 negative regulation of fibril organization(GO:1902904) chaperone-mediated autophagy translocation complex disassembly(GO:1904764)
0.7 2.8 GO:0001808 negative regulation of type IV hypersensitivity(GO:0001808)
0.5 4.1 GO:1903750 regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903750) negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903751)
0.3 1.0 GO:0010160 sensory organ boundary specification(GO:0008052) formation of organ boundary(GO:0010160) taste bud development(GO:0061193)
0.3 0.8 GO:1901340 negative regulation of store-operated calcium channel activity(GO:1901340)
0.3 1.0 GO:2000298 regulation of Rho-dependent protein serine/threonine kinase activity(GO:2000298)
0.3 1.8 GO:0071603 endothelial cell-cell adhesion(GO:0071603)
0.2 2.2 GO:0060715 syncytiotrophoblast cell differentiation involved in labyrinthine layer development(GO:0060715)
0.2 0.7 GO:0045041 B cell cytokine production(GO:0002368) protein import into mitochondrial intermembrane space(GO:0045041)
0.2 1.5 GO:0070370 heat acclimation(GO:0010286) cellular heat acclimation(GO:0070370)
0.2 1.0 GO:0043335 protein unfolding(GO:0043335)
0.2 3.5 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.2 1.4 GO:0032468 Golgi calcium ion homeostasis(GO:0032468)
0.2 0.7 GO:2001160 regulation of histone H3-K79 methylation(GO:2001160) positive regulation of histone H3-K79 methylation(GO:2001162)
0.2 1.4 GO:0045541 negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206)
0.1 0.5 GO:1903660 negative regulation of complement-dependent cytotoxicity(GO:1903660)
0.1 0.4 GO:0071277 cellular response to calcium ion(GO:0071277)
0.1 0.5 GO:0009956 radial pattern formation(GO:0009956)
0.1 0.7 GO:0044034 negative stranded viral RNA replication(GO:0039689) multi-organism biosynthetic process(GO:0044034)
0.1 1.7 GO:1904871 regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871)
0.1 2.3 GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191)
0.1 1.3 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
0.1 0.8 GO:0035494 SNARE complex disassembly(GO:0035494)
0.1 0.5 GO:0002415 immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415)
0.1 0.2 GO:0043397 corticotropin-releasing hormone secretion(GO:0043396) regulation of corticotropin-releasing hormone secretion(GO:0043397) positive regulation of corticotropin-releasing hormone secretion(GO:0051466)
0.1 0.7 GO:0071492 cellular response to UV-A(GO:0071492)
0.1 0.5 GO:0015798 myo-inositol transport(GO:0015798)
0.1 0.3 GO:1902938 regulation of intracellular calcium activated chloride channel activity(GO:1902938) neuron projection maintenance(GO:1990535)
0.1 0.4 GO:0014063 negative regulation of serotonin secretion(GO:0014063)
0.1 0.5 GO:0019236 response to pheromone(GO:0019236)
0.1 1.0 GO:0016926 protein desumoylation(GO:0016926)
0.1 0.2 GO:0008355 olfactory learning(GO:0008355)
0.1 0.2 GO:0045212 negative regulation of synaptic transmission, cholinergic(GO:0032223) neurotransmitter receptor biosynthetic process(GO:0045212)
0.1 0.2 GO:0002424 T cell mediated immune response to tumor cell(GO:0002424) regulation of T cell mediated immune response to tumor cell(GO:0002840)
0.1 0.7 GO:0090204 protein localization to nuclear pore(GO:0090204)
0.1 0.2 GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
0.0 0.5 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.0 0.8 GO:0070970 interleukin-2 secretion(GO:0070970)
0.0 0.3 GO:1902231 regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902162) positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902164) positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231)
0.0 0.9 GO:0030213 hyaluronan biosynthetic process(GO:0030213)
0.0 0.2 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.0 0.5 GO:0016554 cytidine to uridine editing(GO:0016554)
0.0 0.2 GO:0051066 dihydrobiopterin metabolic process(GO:0051066)
0.0 0.2 GO:0072658 maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.0 1.3 GO:0032786 positive regulation of DNA-templated transcription, elongation(GO:0032786)
0.0 0.2 GO:1905098 negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098)
0.0 0.1 GO:0031247 actin rod assembly(GO:0031247)
0.0 1.1 GO:0043968 histone H2A acetylation(GO:0043968)
0.0 0.2 GO:0044856 plasma membrane raft distribution(GO:0044855) plasma membrane raft localization(GO:0044856) plasma membrane raft polarization(GO:0044858) regulation of plasma membrane raft polarization(GO:1903906)
0.0 0.1 GO:0036114 medium-chain fatty-acyl-CoA catabolic process(GO:0036114) long-chain fatty-acyl-CoA catabolic process(GO:0036116) palmitic acid metabolic process(GO:1900533) palmitic acid biosynthetic process(GO:1900535)
0.0 0.6 GO:1902018 negative regulation of cilium assembly(GO:1902018)
0.0 0.6 GO:0070544 histone H3-K36 demethylation(GO:0070544)
0.0 0.2 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.0 0.4 GO:1903599 positive regulation of mitophagy(GO:1903599)
0.0 0.6 GO:0007021 tubulin complex assembly(GO:0007021)
0.0 0.5 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.0 0.2 GO:0048254 snoRNA localization(GO:0048254)
0.0 0.4 GO:0010917 negative regulation of mitochondrial membrane potential(GO:0010917)
0.0 0.1 GO:0003363 lamellipodium assembly involved in ameboidal cell migration(GO:0003363) extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration(GO:0021816)
0.0 0.3 GO:0009249 protein lipoylation(GO:0009249)
0.0 0.4 GO:0097475 motor neuron migration(GO:0097475)
0.0 0.3 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.0 0.4 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.0 0.7 GO:0003094 glomerular filtration(GO:0003094)
0.0 0.4 GO:0031115 negative regulation of microtubule polymerization(GO:0031115)
0.0 0.1 GO:0072738 response to diamide(GO:0072737) cellular response to diamide(GO:0072738)
0.0 0.5 GO:0000183 chromatin silencing at rDNA(GO:0000183)
0.0 0.8 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.1 GO:0006424 glutamyl-tRNA aminoacylation(GO:0006424)
0.0 0.4 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0 0.2 GO:0006983 ER overload response(GO:0006983)
0.0 0.5 GO:0045730 respiratory burst(GO:0045730)
0.0 0.1 GO:2000729 positive regulation of mesenchymal cell proliferation involved in ureter development(GO:2000729)
0.0 0.2 GO:0048706 embryonic skeletal system development(GO:0048706)
0.0 0.9 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.0 0.4 GO:1990126 retrograde transport, endosome to plasma membrane(GO:1990126)
0.0 0.1 GO:0036378 calcitriol biosynthetic process from calciol(GO:0036378)
0.0 0.3 GO:0042110 T cell activation(GO:0042110) leukocyte aggregation(GO:0070486) T cell aggregation(GO:0070489) lymphocyte aggregation(GO:0071593)
0.0 0.1 GO:0070197 meiotic telomere tethering at nuclear periphery(GO:0044821) meiotic attachment of telomere to nuclear envelope(GO:0070197) chromosome attachment to the nuclear envelope(GO:0097240)
0.0 0.1 GO:0042738 exogenous drug catabolic process(GO:0042738)
0.0 0.3 GO:0032802 low-density lipoprotein particle receptor catabolic process(GO:0032802)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 3.7 GO:0098575 lumenal side of lysosomal membrane(GO:0098575)
0.4 1.8 GO:0071665 gamma-catenin-TCF7L2 complex(GO:0071665)
0.2 1.5 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.2 5.2 GO:0071682 endocytic vesicle lumen(GO:0071682)
0.1 0.7 GO:0034274 Atg12-Atg5-Atg16 complex(GO:0034274)
0.1 0.4 GO:0030906 retromer, cargo-selective complex(GO:0030906)
0.1 0.7 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.1 1.7 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.1 0.4 GO:1990037 Lewy body core(GO:1990037)
0.1 0.5 GO:0033553 rDNA heterochromatin(GO:0033553)
0.1 0.5 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.1 0.7 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.1 0.5 GO:0032010 phagolysosome(GO:0032010)
0.0 0.5 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.0 0.2 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.0 0.5 GO:0070775 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0 1.2 GO:0016580 Sin3 complex(GO:0016580)
0.0 2.3 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.6 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 0.9 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 0.6 GO:0097512 cardiac myofibril(GO:0097512)
0.0 0.4 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 0.4 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 0.8 GO:0042101 T cell receptor complex(GO:0042101)
0.0 1.5 GO:0008180 COP9 signalosome(GO:0008180)
0.0 0.2 GO:0061700 GATOR2 complex(GO:0061700)
0.0 0.3 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 0.4 GO:0044295 axonal growth cone(GO:0044295)
0.0 0.2 GO:0043083 synaptic cleft(GO:0043083)
0.0 0.1 GO:0044327 dendritic spine head(GO:0044327)
0.0 0.3 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 0.2 GO:0030478 actin cap(GO:0030478)
0.0 0.8 GO:0016235 aggresome(GO:0016235)
0.0 0.3 GO:0043220 Schmidt-Lanterman incisure(GO:0043220)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.8 GO:0005199 structural constituent of cell wall(GO:0005199)
0.4 2.5 GO:0042015 interleukin-20 binding(GO:0042015)
0.3 3.7 GO:0055131 C3HC4-type RING finger domain binding(GO:0055131)
0.3 4.1 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.2 1.3 GO:0032564 adenyl deoxyribonucleotide binding(GO:0032558) dATP binding(GO:0032564)
0.2 0.5 GO:0005365 myo-inositol transmembrane transporter activity(GO:0005365)
0.1 0.6 GO:0071987 WD40-repeat domain binding(GO:0071987)
0.1 1.0 GO:0005166 neurotrophin p75 receptor binding(GO:0005166)
0.1 0.7 GO:0019776 Atg8 ligase activity(GO:0019776)
0.1 0.7 GO:0034186 apolipoprotein A-I binding(GO:0034186)
0.1 0.4 GO:0032767 copper-dependent protein binding(GO:0032767)
0.1 1.0 GO:0030911 TPR domain binding(GO:0030911)
0.1 0.5 GO:0070137 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.1 3.2 GO:0001671 ATPase activator activity(GO:0001671)
0.1 0.4 GO:0070728 leucine binding(GO:0070728)
0.1 0.5 GO:0016929 SUMO-specific protease activity(GO:0016929)
0.1 0.3 GO:1903135 cupric ion binding(GO:1903135)
0.1 2.3 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.1 0.2 GO:0004155 6,7-dihydropteridine reductase activity(GO:0004155)
0.0 1.5 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.2 GO:0003990 acetylcholinesterase activity(GO:0003990)
0.0 0.9 GO:0043225 anion transmembrane-transporting ATPase activity(GO:0043225)
0.0 0.4 GO:0008131 primary amine oxidase activity(GO:0008131)
0.0 0.7 GO:0016018 cyclosporin A binding(GO:0016018)
0.0 1.4 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.3 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.0 0.2 GO:0010858 calcium-dependent protein kinase regulator activity(GO:0010858)
0.0 0.8 GO:0050700 CARD domain binding(GO:0050700)
0.0 0.6 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0 0.3 GO:1990226 histone methyltransferase binding(GO:1990226)
0.0 0.5 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0 1.5 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 2.0 GO:0015485 cholesterol binding(GO:0015485)
0.0 0.5 GO:0001163 RNA polymerase I regulatory region DNA binding(GO:0001013) RNA polymerase I regulatory region sequence-specific DNA binding(GO:0001163) RNA polymerase I CORE element sequence-specific DNA binding(GO:0001164)
0.0 0.5 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.8 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.1 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.0 0.3 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 3.5 GO:0031072 heat shock protein binding(GO:0031072)
0.0 0.4 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 0.1 GO:0004818 glutamate-tRNA ligase activity(GO:0004818)
0.0 0.7 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 0.4 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 0.1 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
0.0 0.1 GO:0030343 vitamin D3 25-hydroxylase activity(GO:0030343) vitamin D 25-hydroxylase activity(GO:0070643)
0.0 0.8 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.2 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
0.0 0.6 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.0 0.5 GO:0031491 nucleosome binding(GO:0031491)
0.0 0.1 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 1.1 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.6 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.0 0.1 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.0 0.1 GO:0046790 virion binding(GO:0046790)
0.0 0.8 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 1.0 GO:0004177 aminopeptidase activity(GO:0004177)
0.0 0.8 GO:0031593 polyubiquitin binding(GO:0031593)
0.0 0.7 GO:0051082 unfolded protein binding(GO:0051082)
0.0 0.2 GO:0045159 myosin II binding(GO:0045159)
0.0 1.0 GO:0003743 translation initiation factor activity(GO:0003743)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.9 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 1.0 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 1.8 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.0 4.2 PID CMYB PATHWAY C-MYB transcription factor network
0.0 0.9 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 1.4 PID PLK1 PATHWAY PLK1 signaling events
0.0 1.5 PID LKB1 PATHWAY LKB1 signaling events
0.0 0.2 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.9 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.1 3.7 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.1 2.3 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.0 1.0 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 1.8 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 1.1 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0 0.5 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 1.4 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.5 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.0 0.3 REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR Genes involved in Prostacyclin signalling through prostacyclin receptor
0.0 0.9 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 0.4 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.0 0.5 REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.0 0.8 REACTOME DOWNSTREAM TCR SIGNALING Genes involved in Downstream TCR signaling
0.0 1.2 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.0 0.2 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 1.8 REACTOME L1CAM INTERACTIONS Genes involved in L1CAM interactions
0.0 0.7 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling