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SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for IRF2_STAT2_IRF8_IRF1
Z-value: 4.77
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Transcription factors associated with IRF2_STAT2_IRF8_IRF1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000168310.6 | interferon regulatory factor 2 | |
| ENSG00000170581.9 | signal transducer and activator of transcription 2 | |
| ENSG00000140968.6 | interferon regulatory factor 8 | |
| ENSG00000125347.9 | interferon regulatory factor 1 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| STAT2 | hg19_v2_chr12_-_56753858_56753930 | 0.96 | 4.0e-11 | Click! |
| IRF8 | hg19_v2_chr16_+_85942594_85942635 | -0.59 | 5.7e-03 | Click! |
| IRF2 | hg19_v2_chr4_-_185395672_185395734 | 0.57 | 8.2e-03 | Click! |
| IRF1 | hg19_v2_chr5_-_131826457_131826514 | 0.46 | 3.9e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of IRF2_STAT2_IRF8_IRF1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 55.7 | GO:0045824 | negative regulation of innate immune response(GO:0045824) |
| 5.0 | 54.7 | GO:0018377 | protein myristoylation(GO:0018377) |
| 2.2 | 45.7 | GO:0003373 | dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374) |
| 3.0 | 45.6 | GO:0035457 | cellular response to interferon-alpha(GO:0035457) |
| 3.2 | 38.9 | GO:0032020 | ISG15-protein conjugation(GO:0032020) |
| 0.1 | 38.9 | GO:0009615 | response to virus(GO:0009615) |
| 0.4 | 30.3 | GO:0070206 | protein trimerization(GO:0070206) |
| 0.6 | 30.0 | GO:0046825 | regulation of protein export from nucleus(GO:0046825) |
| 0.9 | 28.5 | GO:0035456 | response to interferon-beta(GO:0035456) |
| 6.8 | 27.3 | GO:0034343 | type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 95.1 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.1 | 53.3 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.4 | 38.3 | GO:0015030 | Cajal body(GO:0015030) |
| 4.4 | 30.5 | GO:0097179 | protease inhibitor complex(GO:0097179) |
| 0.3 | 29.0 | GO:0035577 | azurophil granule membrane(GO:0035577) |
| 0.8 | 26.3 | GO:0034385 | very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385) |
| 0.1 | 25.5 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.1 | 22.6 | GO:0045111 | intermediate filament cytoskeleton(GO:0045111) |
| 0.0 | 20.4 | GO:0010008 | endosome membrane(GO:0010008) |
| 0.2 | 19.7 | GO:0005811 | lipid particle(GO:0005811) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 59.4 | GO:0005525 | GTP binding(GO:0005525) |
| 0.2 | 54.3 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.4 | 53.0 | GO:0003725 | double-stranded RNA binding(GO:0003725) |
| 4.4 | 52.5 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.7 | 38.4 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.8 | 31.0 | GO:0005521 | lamin binding(GO:0005521) |
| 0.0 | 30.6 | GO:0008270 | zinc ion binding(GO:0008270) |
| 0.1 | 27.9 | GO:0030674 | protein binding, bridging(GO:0030674) |
| 2.8 | 22.2 | GO:0042289 | MHC class II protein binding(GO:0042289) |
| 0.9 | 21.4 | GO:0008035 | high-density lipoprotein particle binding(GO:0008035) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 27.0 | PID MYC PATHWAY | C-MYC pathway |
| 0.5 | 19.6 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.1 | 17.6 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.2 | 17.3 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.1 | 16.0 | SIG PIP3 SIGNALING IN CARDIAC MYOCTES | Genes related to PIP3 signaling in cardiac myocytes |
| 0.9 | 12.6 | ST TYPE I INTERFERON PATHWAY | Type I Interferon (alpha/beta IFN) Pathway |
| 0.1 | 12.5 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.0 | 11.9 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 11.4 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
| 0.1 | 10.1 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.2 | 322.8 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.5 | 34.5 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.6 | 28.9 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 1.3 | 21.5 | REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY | Genes involved in TRAF3-dependent IRF activation pathway |
| 1.0 | 21.1 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.4 | 17.0 | REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS | Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways |
| 0.2 | 15.0 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.2 | 14.8 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.7 | 13.6 | REACTOME PD1 SIGNALING | Genes involved in PD-1 signaling |
| 0.1 | 12.8 | REACTOME O LINKED GLYCOSYLATION OF MUCINS | Genes involved in O-linked glycosylation of mucins |