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SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for IRF3

Z-value: 1.54

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Transcription factors associated with IRF3

Gene Symbol Gene ID Gene Info
IRF3
ENSG00000126456.11 interferon regulatory factor 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
IRF3hg19_v2_chr19_-_50169064_501691320.579.1e-03Click!

Activity profile of IRF3 motif

Sorted Z-values of IRF3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_948803 7.84 ENST00000379389.4
ISG15
ISG15 ubiquitin-like modifier
chr10_+_91087651 5.62 ENST00000371818.4
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr1_+_79115503 4.96 ENST00000370747.4
ENST00000438486.1
ENST00000545124.1
IFI44
interferon-induced protein 44
chr10_+_91092241 4.76 ENST00000371811.4
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr21_+_42792442 4.13 ENST00000398600.2
MX1
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr2_-_163175133 4.06 ENST00000421365.2
ENST00000263642.2
IFIH1
interferon induced with helicase C domain 1
chr12_+_113416191 3.77 ENST00000342315.4
ENST00000392583.2
OAS2
2'-5'-oligoadenylate synthetase 2, 69/71kDa
chr3_-_172241250 3.64 ENST00000420541.2
ENST00000241261.2
TNFSF10
tumor necrosis factor (ligand) superfamily, member 10
chr11_-_615570 3.48 ENST00000525445.1
ENST00000348655.6
ENST00000397566.1
IRF7
interferon regulatory factor 7
chr11_-_615942 3.44 ENST00000397562.3
ENST00000330243.5
ENST00000397570.1
ENST00000397574.2
IRF7
interferon regulatory factor 7
chr22_+_36649056 3.36 ENST00000397278.3
ENST00000422706.1
ENST00000426053.1
ENST00000319136.4
APOL1
apolipoprotein L, 1
chr12_+_113416265 3.30 ENST00000449768.2
OAS2
2'-5'-oligoadenylate synthetase 2, 69/71kDa
chr19_-_17516449 3.27 ENST00000252593.6
BST2
bone marrow stromal cell antigen 2
chr10_+_91061712 2.90 ENST00000371826.3
IFIT2
interferon-induced protein with tetratricopeptide repeats 2
chr22_+_36649170 2.65 ENST00000438034.1
ENST00000427990.1
ENST00000347595.7
ENST00000397279.4
ENST00000433768.1
ENST00000440669.2
APOL1
apolipoprotein L, 1
chr7_-_92747269 2.60 ENST00000446617.1
ENST00000379958.2
SAMD9
sterile alpha motif domain containing 9
chr17_+_6659153 2.54 ENST00000441631.1
ENST00000438512.1
ENST00000346752.4
ENST00000361842.3
XAF1
XIAP associated factor 1
chr19_+_10196781 2.54 ENST00000253110.11
C19orf66
chromosome 19 open reading frame 66
chr16_-_11350036 2.52 ENST00000332029.2
SOCS1
suppressor of cytokine signaling 1
chr2_-_231084820 2.25 ENST00000258382.5
ENST00000338556.3
SP110
SP110 nuclear body protein
chr2_-_231084659 2.25 ENST00000258381.6
ENST00000358662.4
ENST00000455674.1
ENST00000392048.3
SP110
SP110 nuclear body protein
chr7_-_92777606 2.24 ENST00000437805.1
ENST00000446959.1
ENST00000439952.1
ENST00000414791.1
ENST00000446033.1
ENST00000411955.1
ENST00000318238.4
SAMD9L
sterile alpha motif domain containing 9-like
chr12_-_10022735 2.16 ENST00000228438.2
CLEC2B
C-type lectin domain family 2, member B
chr19_+_10196981 2.13 ENST00000591813.1
C19orf66
chromosome 19 open reading frame 66
chr22_-_36635684 2.11 ENST00000358502.5
APOL2
apolipoprotein L, 2
chr3_-_122283100 2.06 ENST00000492382.1
ENST00000462315.1
PARP9
poly (ADP-ribose) polymerase family, member 9
chr3_-_122283424 1.77 ENST00000477522.2
ENST00000360356.2
PARP9
poly (ADP-ribose) polymerase family, member 9
chr12_+_113416340 1.73 ENST00000552756.1
OAS2
2'-5'-oligoadenylate synthetase 2, 69/71kDa
chr19_+_39786962 1.70 ENST00000333625.2
IFNL1
interferon, lambda 1
chr3_-_122283079 1.64 ENST00000471785.1
ENST00000466126.1
PARP9
poly (ADP-ribose) polymerase family, member 9
chrX_+_57313113 1.57 ENST00000374900.4
FAAH2
fatty acid amide hydrolase 2
chr9_+_5450503 1.56 ENST00000381573.4
ENST00000381577.3
CD274
CD274 molecule
chr2_-_231084617 1.49 ENST00000409815.2
SP110
SP110 nuclear body protein
chr11_-_57335280 1.48 ENST00000287156.4
UBE2L6
ubiquitin-conjugating enzyme E2L 6
chr7_-_139756791 1.47 ENST00000489809.1
PARP12
poly (ADP-ribose) polymerase family, member 12
chr3_+_187086120 1.44 ENST00000259030.2
RTP4
receptor (chemosensory) transporter protein 4
chr22_-_36635563 1.42 ENST00000451256.2
APOL2
apolipoprotein L, 2
chr1_+_150480551 1.32 ENST00000369049.4
ENST00000369047.4
ECM1
extracellular matrix protein 1
chr17_+_25958174 1.29 ENST00000313648.6
ENST00000577392.1
ENST00000584661.1
ENST00000413914.2
LGALS9
lectin, galactoside-binding, soluble, 9
chr9_-_32526299 1.28 ENST00000379882.1
ENST00000379883.2
DDX58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr22_-_36635598 1.26 ENST00000454728.1
APOL2
apolipoprotein L, 2
chr17_-_7166500 1.25 ENST00000575313.1
ENST00000397317.4
CLDN7
claudin 7
chr6_+_32821924 1.23 ENST00000374859.2
ENST00000453265.2
PSMB9
proteasome (prosome, macropain) subunit, beta type, 9
chr1_-_161015752 1.22 ENST00000435396.1
ENST00000368021.3
USF1
upstream transcription factor 1
chr2_+_218933972 1.18 ENST00000374155.3
RUFY4
RUN and FYVE domain containing 4
chr4_-_169239921 1.18 ENST00000514995.1
ENST00000393743.3
DDX60
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
chr11_+_124735282 1.17 ENST00000397801.1
ROBO3
roundabout, axon guidance receptor, homolog 3 (Drosophila)
chr1_+_159931002 1.15 ENST00000443364.1
ENST00000423943.1
RP11-48O20.4
long intergenic non-protein coding RNA 1133
chr7_+_142829162 1.13 ENST00000291009.3
PIP
prolactin-induced protein
chr22_-_36556821 1.11 ENST00000531095.1
ENST00000397293.2
ENST00000349314.2
APOL3
apolipoprotein L, 3
chr11_-_57334732 1.10 ENST00000526659.1
ENST00000527022.1
UBE2L6
ubiquitin-conjugating enzyme E2L 6
chr6_-_36355513 1.10 ENST00000340181.4
ENST00000373737.4
ETV7
ets variant 7
chr22_+_36044411 1.10 ENST00000409652.4
APOL6
apolipoprotein L, 6
chr4_+_118955500 1.07 ENST00000296499.5
NDST3
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
chr19_+_49977466 1.07 ENST00000596435.1
ENST00000344019.3
ENST00000597551.1
ENST00000204637.2
ENST00000600429.1
FLT3LG
fms-related tyrosine kinase 3 ligand
chr20_-_47894569 1.06 ENST00000371744.1
ENST00000371752.1
ENST00000396105.1
ZNFX1
zinc finger, NFX1-type containing 1
chr5_-_95158375 1.05 ENST00000512469.2
ENST00000379979.4
ENST00000505427.1
ENST00000508780.1
GLRX
glutaredoxin (thioltransferase)
chr1_+_150480576 1.05 ENST00000346569.6
ECM1
extracellular matrix protein 1
chr5_-_95158644 1.04 ENST00000237858.6
GLRX
glutaredoxin (thioltransferase)
chr22_-_36635225 1.00 ENST00000529194.1
APOL2
apolipoprotein L, 2
chr9_-_32526184 0.99 ENST00000545044.1
ENST00000379868.1
DDX58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr1_-_177939041 0.98 ENST00000308284.6
SEC16B
SEC16 homolog B (S. cerevisiae)
chr6_-_32821599 0.97 ENST00000354258.4
TAP1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr4_-_156875003 0.97 ENST00000433477.3
CTSO
cathepsin O
chr12_-_99288536 0.96 ENST00000549797.1
ENST00000333732.7
ENST00000341752.7
ANKS1B
ankyrin repeat and sterile alpha motif domain containing 1B
chr22_+_18632666 0.91 ENST00000215794.7
USP18
ubiquitin specific peptidase 18
chr11_-_4414880 0.89 ENST00000254436.7
ENST00000543625.1
TRIM21
tripartite motif containing 21
chr2_-_73869508 0.87 ENST00000272425.3
NAT8
N-acetyltransferase 8 (GCN5-related, putative)
chr8_+_39770803 0.86 ENST00000518237.1
IDO1
indoleamine 2,3-dioxygenase 1
chr6_-_32806506 0.84 ENST00000374897.2
ENST00000452392.2
TAP2
TAP2
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
Uncharacterized protein
chr11_+_5646213 0.83 ENST00000429814.2
TRIM34
tripartite motif containing 34
chr6_+_28227063 0.83 ENST00000343684.3
NKAPL
NFKB activating protein-like
chr9_-_14322319 0.83 ENST00000606230.1
NFIB
nuclear factor I/B
chr9_-_100954910 0.83 ENST00000375077.4
CORO2A
coronin, actin binding protein, 2A
chr6_-_36355486 0.81 ENST00000538992.1
ETV7
ets variant 7
chr2_-_166651152 0.79 ENST00000431484.1
ENST00000412248.1
GALNT3
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)
chr18_-_8337038 0.78 ENST00000594251.1
AP001094.1
Uncharacterized protein
chr1_-_161015663 0.78 ENST00000534633.1
USF1
upstream transcription factor 1
chr12_+_14369524 0.74 ENST00000538329.1
RP11-134N1.2
RP11-134N1.2
chr2_-_166651191 0.72 ENST00000392701.3
GALNT3
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)
chr1_-_89664595 0.71 ENST00000355754.6
GBP4
guanylate binding protein 4
chr4_+_130017268 0.68 ENST00000425929.1
ENST00000508673.1
ENST00000508622.1
C4orf33
chromosome 4 open reading frame 33
chr3_+_122399444 0.67 ENST00000474629.2
PARP14
poly (ADP-ribose) polymerase family, member 14
chr4_+_89378261 0.66 ENST00000264350.3
HERC5
HECT and RLD domain containing E3 ubiquitin protein ligase 5
chr17_+_6659354 0.65 ENST00000574907.1
XAF1
XIAP associated factor 1
chr19_+_50432400 0.64 ENST00000423777.2
ENST00000600336.1
ENST00000597227.1
ATF5
activating transcription factor 5
chr12_-_133613794 0.63 ENST00000443154.3
RP11-386I8.6
RP11-386I8.6
chr12_-_133787772 0.62 ENST00000545350.1
AC226150.4
Uncharacterized protein
chr3_+_122283064 0.60 ENST00000296161.4
DTX3L
deltex 3-like (Drosophila)
chr2_-_157198860 0.60 ENST00000409572.1
NR4A2
nuclear receptor subfamily 4, group A, member 2
chr20_+_61436146 0.59 ENST00000290291.6
OGFR
opioid growth factor receptor
chr20_+_388791 0.59 ENST00000441733.1
ENST00000353660.3
RBCK1
RanBP-type and C3HC4-type zinc finger containing 1
chr20_+_388679 0.58 ENST00000356286.5
ENST00000475269.1
RBCK1
RanBP-type and C3HC4-type zinc finger containing 1
chr17_-_40264692 0.58 ENST00000591220.1
ENST00000251642.3
DHX58
DEXH (Asp-Glu-X-His) box polypeptide 58
chr9_+_77112244 0.58 ENST00000376896.3
RORB
RAR-related orphan receptor B
chr15_-_55611306 0.57 ENST00000563262.1
RAB27A
RAB27A, member RAS oncogene family
chr7_-_32931387 0.56 ENST00000304056.4
KBTBD2
kelch repeat and BTB (POZ) domain containing 2
chr14_-_24615523 0.56 ENST00000559056.1
PSME2
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr19_+_13051206 0.54 ENST00000586760.1
CALR
calreticulin
chr6_-_32806483 0.52 ENST00000374899.4
TAP2
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
chr6_-_3752222 0.51 ENST00000380283.4
PXDC1
PX domain containing 1
chr6_+_41748500 0.51 ENST00000458694.1
ENST00000359201.5
PRICKLE4
prickle homolog 4 (Drosophila)
chr14_-_24615805 0.51 ENST00000560410.1
PSME2
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr10_-_49701686 0.50 ENST00000417247.2
ARHGAP22
Rho GTPase activating protein 22
chr15_+_45003675 0.50 ENST00000558401.1
ENST00000559916.1
ENST00000544417.1
B2M
beta-2-microglobulin
chr12_+_133614119 0.46 ENST00000327668.7
ZNF84
zinc finger protein 84
chr15_+_64428529 0.46 ENST00000560861.1
SNX1
sorting nexin 1
chr12_+_6561190 0.45 ENST00000544021.1
ENST00000266556.7
TAPBPL
TAP binding protein-like
chr2_-_214017151 0.44 ENST00000452786.1
IKZF2
IKAROS family zinc finger 2 (Helios)
chr4_-_169401628 0.44 ENST00000514748.1
ENST00000512371.1
ENST00000260184.7
ENST00000505890.1
ENST00000511577.1
DDX60L
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like
chr7_-_138794394 0.44 ENST00000242351.5
ENST00000471652.1
ZC3HAV1
zinc finger CCCH-type, antiviral 1
chr1_-_161014731 0.43 ENST00000368020.1
USF1
upstream transcription factor 1
chr20_+_388935 0.43 ENST00000382181.2
ENST00000400247.3
RBCK1
RanBP-type and C3HC4-type zinc finger containing 1
chr12_-_54582655 0.43 ENST00000504338.1
ENST00000514685.1
ENST00000504797.1
ENST00000513838.1
ENST00000505128.1
ENST00000337581.3
ENST00000503306.1
ENST00000243112.5
ENST00000514196.1
ENST00000506169.1
ENST00000507904.1
ENST00000508394.2
SMUG1
single-strand-selective monofunctional uracil-DNA glycosylase 1
chr5_-_77656175 0.43 ENST00000513755.1
ENST00000421004.3
CTD-2037K23.2
CTD-2037K23.2
chr12_+_133613937 0.41 ENST00000539354.1
ENST00000542874.1
ENST00000438628.2
ZNF84
zinc finger protein 84
chr22_+_39436862 0.41 ENST00000381565.2
ENST00000452957.2
APOBEC3F
APOBEC3G
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
chr11_-_67418120 0.39 ENST00000255082.3
ACY3
aspartoacylase (aminocyclase) 3
chr12_+_113376157 0.39 ENST00000228928.7
OAS3
2'-5'-oligoadenylate synthetase 3, 100kDa
chrX_+_77154935 0.39 ENST00000481445.1
COX7B
cytochrome c oxidase subunit VIIb
chr1_-_177939348 0.39 ENST00000464631.2
SEC16B
SEC16 homolog B (S. cerevisiae)
chr5_+_131746575 0.37 ENST00000337752.2
ENST00000378947.3
ENST00000407797.1
C5orf56
chromosome 5 open reading frame 56
chrX_+_146993648 0.37 ENST00000370470.1
FMR1
fragile X mental retardation 1
chrX_+_52920336 0.37 ENST00000452154.2
FAM156B
family with sequence similarity 156, member B
chr12_+_133613878 0.35 ENST00000392319.2
ENST00000543758.1
ZNF84
zinc finger protein 84
chr10_-_120355149 0.34 ENST00000239032.2
PRLHR
prolactin releasing hormone receptor
chr12_-_4758159 0.34 ENST00000545990.2
AKAP3
A kinase (PRKA) anchor protein 3
chr14_+_24605361 0.34 ENST00000206451.6
ENST00000559123.1
PSME1
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr17_+_6658878 0.33 ENST00000574394.1
XAF1
XIAP associated factor 1
chr22_+_31892261 0.32 ENST00000432498.1
ENST00000540643.1
ENST00000443326.1
ENST00000414585.1
SFI1
Sfi1 homolog, spindle assembly associated (yeast)
chr6_+_28193037 0.32 ENST00000531981.1
ENST00000425468.2
ENST00000252207.5
ENST00000531979.1
ENST00000527436.1
ZSCAN9
zinc finger and SCAN domain containing 9
chr6_-_28226984 0.31 ENST00000423974.2
ZKSCAN4
zinc finger with KRAB and SCAN domains 4
chr1_-_159046617 0.30 ENST00000368130.4
AIM2
absent in melanoma 2
chr1_+_110577229 0.28 ENST00000369795.3
ENST00000369794.2
STRIP1
striatin interacting protein 1
chr12_-_8218997 0.27 ENST00000307637.4
C3AR1
complement component 3a receptor 1
chr6_-_30181133 0.26 ENST00000454678.2
ENST00000434785.1
TRIM26
tripartite motif containing 26
chr11_-_110968081 0.26 ENST00000603154.1
RP11-89C3.4
RP11-89C3.4
chr17_+_36861735 0.25 ENST00000378137.5
ENST00000325718.7
MLLT6
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6
chr14_-_91976794 0.25 ENST00000555462.1
SMEK1
SMEK homolog 1, suppressor of mek1 (Dictyostelium)
chr14_+_73525144 0.25 ENST00000261973.7
ENST00000540173.1
RBM25
RNA binding motif protein 25
chr7_-_122526411 0.23 ENST00000449022.2
CADPS2
Ca++-dependent secretion activator 2
chr5_-_180288248 0.23 ENST00000512132.1
ENST00000506439.1
ENST00000502412.1
ENST00000359141.6
ZFP62
ZFP62 zinc finger protein
chr2_+_127413677 0.22 ENST00000356887.7
GYPC
glycophorin C (Gerbich blood group)
chr16_+_66968343 0.21 ENST00000417689.1
ENST00000561697.1
ENST00000317091.4
ENST00000566182.1
CES2
carboxylesterase 2
chrX_+_146993449 0.21 ENST00000218200.8
ENST00000370471.3
ENST00000370477.1
FMR1
fragile X mental retardation 1
chr19_+_18284477 0.20 ENST00000407280.3
IFI30
interferon, gamma-inducible protein 30
chr22_+_31892373 0.20 ENST00000443011.1
ENST00000400289.1
ENST00000444859.1
ENST00000400288.2
SFI1
Sfi1 homolog, spindle assembly associated (yeast)
chr4_-_87855851 0.18 ENST00000473559.1
C4orf36
chromosome 4 open reading frame 36
chr7_-_122526799 0.18 ENST00000334010.7
ENST00000313070.7
CADPS2
Ca++-dependent secretion activator 2
chr1_+_25599018 0.17 ENST00000417538.2
ENST00000357542.4
ENST00000568195.1
ENST00000342055.5
ENST00000423810.2
RHD
Rh blood group, D antigen
chrX_+_146993534 0.17 ENST00000334557.6
ENST00000439526.2
ENST00000370475.4
FMR1
fragile X mental retardation 1
chr4_+_124320665 0.16 ENST00000394339.2
SPRY1
sprouty homolog 1, antagonist of FGF signaling (Drosophila)
chr14_+_86401039 0.16 ENST00000557195.1
CTD-2341M24.1
CTD-2341M24.1
chr4_+_100495864 0.16 ENST00000265517.5
ENST00000422897.2
MTTP
microsomal triglyceride transfer protein
chr6_+_26440700 0.16 ENST00000494393.1
ENST00000482451.1
ENST00000244519.2
ENST00000339789.4
ENST00000471353.1
ENST00000361232.3
ENST00000487627.1
ENST00000496719.1
ENST00000490254.1
ENST00000487272.1
BTN3A3
butyrophilin, subfamily 3, member A3
chr16_+_29127282 0.16 ENST00000562902.1
RP11-426C22.5
RP11-426C22.5
chr1_+_25598872 0.16 ENST00000328664.4
RHD
Rh blood group, D antigen
chr4_+_156588350 0.15 ENST00000296518.7
GUCY1A3
guanylate cyclase 1, soluble, alpha 3
chr1_+_25598989 0.15 ENST00000454452.2
RHD
Rh blood group, D antigen
chr12_+_113376249 0.15 ENST00000551007.1
ENST00000548514.1
OAS3
2'-5'-oligoadenylate synthetase 3, 100kDa
chr11_-_93583697 0.14 ENST00000409977.1
VSTM5
V-set and transmembrane domain containing 5
chr7_-_122526499 0.14 ENST00000412584.2
CADPS2
Ca++-dependent secretion activator 2
chr6_-_2876744 0.14 ENST00000420981.2
RP11-420G6.4
RP11-420G6.4
chr2_+_127413481 0.12 ENST00000259254.4
GYPC
glycophorin C (Gerbich blood group)
chr12_-_11339543 0.12 ENST00000334266.1
TAS2R42
taste receptor, type 2, member 42
chr12_+_133614062 0.12 ENST00000540031.1
ENST00000536123.1
ZNF84
zinc finger protein 84
chr2_+_113672770 0.12 ENST00000311328.2
IL37
interleukin 37
chr6_+_134758827 0.12 ENST00000431422.1
LINC01010
long intergenic non-protein coding RNA 1010
chr1_+_151129135 0.12 ENST00000602841.1
SCNM1
sodium channel modifier 1
chr16_-_67970990 0.11 ENST00000358514.4
PSMB10
proteasome (prosome, macropain) subunit, beta type, 10
chr2_+_219125714 0.11 ENST00000522678.1
ENST00000519574.1
ENST00000521462.1
GPBAR1
G protein-coupled bile acid receptor 1
chr20_+_20033158 0.10 ENST00000340348.6
ENST00000377309.2
ENST00000389656.3
ENST00000377306.1
ENST00000245957.5
ENST00000377303.2
ENST00000475466.1
C20orf26
chromosome 20 open reading frame 26
chr4_+_156587853 0.10 ENST00000506455.1
ENST00000511108.1
GUCY1A3
guanylate cyclase 1, soluble, alpha 3
chrX_+_154610428 0.10 ENST00000354514.4
H2AFB2
H2A histone family, member B2
chr14_+_73525229 0.09 ENST00000527432.1
ENST00000531500.1
ENST00000525321.1
ENST00000526754.1
RBM25
RNA binding motif protein 25
chr2_-_119605253 0.09 ENST00000295206.6
EN1
engrailed homeobox 1
chr4_+_87856129 0.09 ENST00000395146.4
ENST00000507468.1
AFF1
AF4/FMR2 family, member 1
chr12_-_322821 0.09 ENST00000359674.4
SLC6A12
solute carrier family 6 (neurotransmitter transporter), member 12
chr2_+_127413704 0.08 ENST00000409836.3
GYPC
glycophorin C (Gerbich blood group)
chr8_+_70476088 0.08 ENST00000525999.1
SULF1
sulfatase 1
chr14_+_24605389 0.07 ENST00000382708.3
ENST00000561435.1
PSME1
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr5_+_140749803 0.07 ENST00000576222.1
PCDHGB3
protocadherin gamma subfamily B, 3
chr4_+_156587979 0.07 ENST00000511507.1
GUCY1A3
guanylate cyclase 1, soluble, alpha 3
chr6_+_42018251 0.07 ENST00000372978.3
ENST00000494547.1
ENST00000456846.2
ENST00000372982.4
ENST00000472818.1
ENST00000372977.3
TAF8
TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa
chr4_+_156588115 0.07 ENST00000455639.2
GUCY1A3
guanylate cyclase 1, soluble, alpha 3
chr7_+_134832808 0.06 ENST00000275767.3
TMEM140
transmembrane protein 140
chr16_+_75681650 0.06 ENST00000300086.4
TERF2IP
telomeric repeat binding factor 2, interacting protein
chr4_-_74847800 0.06 ENST00000296029.3
PF4
platelet factor 4
chr4_+_156588249 0.05 ENST00000393832.3
GUCY1A3
guanylate cyclase 1, soluble, alpha 3
chr12_+_12223867 0.04 ENST00000308721.5
BCL2L14
BCL2-like 14 (apoptosis facilitator)
chr10_-_22292675 0.04 ENST00000376946.1
DNAJC1
DnaJ (Hsp40) homolog, subfamily C, member 1
chr3_+_183815318 0.04 ENST00000425359.2
HTR3E
5-hydroxytryptamine (serotonin) receptor 3E, ionotropic
chr6_+_26402465 0.03 ENST00000476549.2
ENST00000289361.6
ENST00000450085.2
ENST00000425234.2
ENST00000427334.1
ENST00000506698.1
BTN3A1
butyrophilin, subfamily 3, member A1
chr2_-_99485825 0.03 ENST00000423771.1
KIAA1211L
KIAA1211-like
chr2_-_175629135 0.02 ENST00000409542.1
ENST00000409219.1
CHRNA1
cholinergic receptor, nicotinic, alpha 1 (muscle)
chr6_-_711395 0.02 ENST00000606285.1
RP11-532F6.3
RP11-532F6.3
chr2_-_175629164 0.02 ENST00000409323.1
ENST00000261007.5
ENST00000348749.5
CHRNA1
cholinergic receptor, nicotinic, alpha 1 (muscle)
chr7_-_126892303 0.01 ENST00000358373.3
GRM8
glutamate receptor, metabotropic 8
chr12_+_12224331 0.01 ENST00000396367.1
ENST00000266434.4
ENST00000396369.1
BCL2L14
BCL2-like 14 (apoptosis facilitator)
chr20_-_56195525 0.00 ENST00000371173.3
ENST00000395822.3
ENST00000340462.4
ENST00000343535.4
ZBP1
Z-DNA binding protein 1

Network of associatons between targets according to the STRING database.

First level regulatory network of IRF3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 6.3 GO:0034344 type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344)
1.4 6.9 GO:2000110 negative regulation of macrophage apoptotic process(GO:2000110)
1.1 3.3 GO:1901253 negative regulation of dendritic cell cytokine production(GO:0002731) negative regulation of intracellular transport of viral material(GO:1901253)
0.9 11.1 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.9 13.3 GO:0035457 cellular response to interferon-alpha(GO:0035457)
0.8 8.8 GO:0018377 protein myristoylation(GO:0018377)
0.6 2.3 GO:0046967 cytosol to ER transport(GO:0046967)
0.4 0.4 GO:0002590 regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002589) negative regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002590)
0.4 1.3 GO:0002519 natural killer cell tolerance induction(GO:0002519) positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:2001190)
0.4 5.1 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.3 2.4 GO:0000432 regulation of transcription from RNA polymerase II promoter by glucose(GO:0000430) positive regulation of transcription from RNA polymerase II promoter by glucose(GO:0000432)
0.3 4.7 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.3 2.5 GO:0045591 positive regulation of regulatory T cell differentiation(GO:0045591)
0.2 0.7 GO:0044830 modulation by host of viral RNA genome replication(GO:0044830) positive regulation of intracellular transport of viral material(GO:1901254)
0.2 0.5 GO:0002428 antigen processing and presentation of peptide antigen via MHC class Ib(GO:0002428)
0.2 0.9 GO:0090086 negative regulation of protein deubiquitination(GO:0090086)
0.2 0.9 GO:0036269 swimming behavior(GO:0036269)
0.2 0.6 GO:0051866 general adaptation syndrome(GO:0051866)
0.2 4.1 GO:0003374 dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374)
0.2 1.5 GO:0018242 protein O-linked glycosylation via serine(GO:0018242)
0.2 1.7 GO:0032696 negative regulation of interleukin-13 production(GO:0032696)
0.2 1.6 GO:0097039 protein linear polyubiquitination(GO:0097039)
0.1 1.6 GO:2001181 positive regulation of interleukin-10 secretion(GO:2001181)
0.1 1.0 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.1 0.8 GO:1900245 positive regulation of MDA-5 signaling pathway(GO:1900245)
0.1 0.7 GO:0030885 regulation of myeloid dendritic cell activation(GO:0030885)
0.1 0.5 GO:0002501 peptide antigen assembly with MHC protein complex(GO:0002501)
0.1 3.4 GO:0097296 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097296)
0.1 6.0 GO:0044364 killing of cells of other organism(GO:0031640) disruption of cells of other organism(GO:0044364)
0.1 0.1 GO:0038183 bile acid signaling pathway(GO:0038183)
0.1 1.2 GO:0016199 axon midline choice point recognition(GO:0016199)
0.1 0.8 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.1 3.8 GO:0035456 response to interferon-beta(GO:0035456)
0.1 2.7 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.1 0.6 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
0.1 2.4 GO:2000404 regulation of T cell migration(GO:2000404)
0.1 0.4 GO:0052551 response to defense-related nitric oxide production by other organism involved in symbiotic interaction(GO:0052551) response to defense-related host nitric oxide production(GO:0052565)
0.1 0.6 GO:0035881 amacrine cell differentiation(GO:0035881)
0.1 2.1 GO:0045838 positive regulation of membrane potential(GO:0045838)
0.1 1.4 GO:0016559 peroxisome fission(GO:0016559)
0.1 1.1 GO:0030202 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014) heparin metabolic process(GO:0030202) heparin biosynthetic process(GO:0030210)
0.1 0.4 GO:0070383 DNA cytosine deamination(GO:0070383)
0.1 0.9 GO:0060338 regulation of type I interferon-mediated signaling pathway(GO:0060338)
0.1 5.8 GO:0060135 maternal process involved in female pregnancy(GO:0060135)
0.1 0.6 GO:1990504 dense core granule exocytosis(GO:1990504)
0.0 0.6 GO:0038003 opioid receptor signaling pathway(GO:0038003)
0.0 0.5 GO:0060700 regulation of ribonuclease activity(GO:0060700)
0.0 0.2 GO:0060940 epithelial to mesenchymal transition involved in cardiac fibroblast development(GO:0060940)
0.0 1.2 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.0 0.3 GO:0021891 olfactory bulb interneuron development(GO:0021891)
0.0 0.5 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.0 2.8 GO:0006521 regulation of cellular amino acid metabolic process(GO:0006521)
0.0 0.4 GO:0045008 depyrimidination(GO:0045008)
0.0 0.1 GO:0061743 motor learning(GO:0061743)
0.0 1.6 GO:0019369 arachidonic acid metabolic process(GO:0019369)
0.0 0.3 GO:0002430 complement receptor mediated signaling pathway(GO:0002430)
0.0 0.4 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 0.9 GO:0050435 beta-amyloid metabolic process(GO:0050435)
0.0 0.4 GO:0015695 organic cation transport(GO:0015695)
0.0 0.2 GO:0034378 chylomicron assembly(GO:0034378)
0.0 0.1 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.0 0.8 GO:0070206 protein trimerization(GO:0070206)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.7 GO:0032002 interleukin-28 receptor complex(GO:0032002)
0.3 2.3 GO:0042825 TAP complex(GO:0042825)
0.3 0.5 GO:0042824 MHC class I peptide loading complex(GO:0042824)
0.3 1.6 GO:0071797 LUBAC complex(GO:0071797)
0.2 0.7 GO:1902737 dendritic filopodium(GO:1902737)
0.2 1.5 GO:0008537 proteasome activator complex(GO:0008537)
0.2 2.3 GO:0016589 NURF complex(GO:0016589)
0.2 6.0 GO:0034385 very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)
0.2 1.3 GO:1990111 spermatoproteasome complex(GO:1990111)
0.1 2.4 GO:0031089 platelet dense granule lumen(GO:0031089)
0.1 0.9 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.1 0.4 GO:0030895 apolipoprotein B mRNA editing enzyme complex(GO:0030895)
0.1 0.5 GO:0031905 early endosome lumen(GO:0031905)
0.1 0.5 GO:0030905 retromer, tubulation complex(GO:0030905)
0.0 3.8 GO:0005771 multivesicular body(GO:0005771)
0.0 0.8 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.0 0.3 GO:0097169 AIM2 inflammasome complex(GO:0097169)
0.0 1.2 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.3 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 0.7 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
0.0 0.4 GO:0045277 respiratory chain complex IV(GO:0045277)
0.0 0.1 GO:0020003 symbiont-containing vacuole(GO:0020003) symbiont-containing vacuole membrane(GO:0020005)
0.0 3.4 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 1.6 GO:0005811 lipid particle(GO:0005811)
0.0 0.4 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 1.4 GO:0009986 cell surface(GO:0009986)
0.0 1.6 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 1.0 GO:0015030 Cajal body(GO:0015030)
0.0 0.9 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0 2.3 GO:0032587 ruffle membrane(GO:0032587)
0.0 12.0 GO:0048471 perinuclear region of cytoplasm(GO:0048471)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 9.3 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.6 7.8 GO:0031386 protein tag(GO:0031386)
0.3 2.4 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.3 3.2 GO:0042296 ISG15 transferase activity(GO:0042296)
0.3 1.3 GO:0048030 disaccharide binding(GO:0048030)
0.3 1.4 GO:0031849 olfactory receptor binding(GO:0031849)
0.3 1.4 GO:0015433 peptide antigen-transporting ATPase activity(GO:0015433)
0.2 1.0 GO:0015440 peptide-transporting ATPase activity(GO:0015440) TAP binding(GO:0046977) TAP1 binding(GO:0046978) TAP2 binding(GO:0046979)
0.2 5.8 GO:0008035 high-density lipoprotein particle binding(GO:0008035)
0.2 0.9 GO:0033754 indoleamine 2,3-dioxygenase activity(GO:0033754)
0.2 1.5 GO:0061133 endopeptidase activator activity(GO:0061133)
0.2 5.1 GO:0070403 NAD+ binding(GO:0070403)
0.1 2.1 GO:0015038 glutathione disulfide oxidoreductase activity(GO:0015038)
0.1 1.1 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.1 1.1 GO:0019864 IgG binding(GO:0019864)
0.1 0.9 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.1 0.7 GO:0034046 poly(G) binding(GO:0034046)
0.1 3.3 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 0.5 GO:1990460 leptin receptor binding(GO:1990460)
0.1 0.4 GO:0000702 oxidized base lesion DNA N-glycosylase activity(GO:0000702)
0.1 0.4 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
0.1 3.3 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.1 0.5 GO:0001849 complement component C1q binding(GO:0001849)
0.1 0.6 GO:0004985 opioid receptor activity(GO:0004985)
0.1 6.9 GO:0003725 double-stranded RNA binding(GO:0003725)
0.1 7.5 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0 2.5 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.0 1.3 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.2 GO:0047374 methylumbelliferyl-acetate deacetylase activity(GO:0047374)
0.0 0.4 GO:0004046 aminoacylase activity(GO:0004046)
0.0 1.4 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 6.0 GO:0005254 chloride channel activity(GO:0005254)
0.0 1.5 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 2.4 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.0 0.3 GO:0004983 neuropeptide Y receptor activity(GO:0004983)
0.0 0.6 GO:0031489 myosin V binding(GO:0031489)
0.0 0.3 GO:0004875 complement receptor activity(GO:0004875)
0.0 1.0 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.1 GO:0038181 bile acid receptor activity(GO:0038181)
0.0 0.1 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.0 0.4 GO:0004383 guanylate cyclase activity(GO:0004383)
0.0 0.4 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.4 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.0 1.6 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.5 SIG IL4RECEPTOR IN B LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes
0.0 6.9 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 2.4 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 1.4 PID TRAIL PATHWAY TRAIL signaling pathway
0.0 0.5 PID THROMBIN PAR1 PATHWAY PAR1-mediated thrombin signaling events
0.0 3.5 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.9 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 0.8 PID HNF3A PATHWAY FOXA1 transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 13.2 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.4 40.1 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.1 0.5 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.1 3.2 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.1 5.7 REACTOME ER PHAGOSOME PATHWAY Genes involved in ER-Phagosome pathway
0.1 1.6 REACTOME PD1 SIGNALING Genes involved in PD-1 signaling
0.0 2.1 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 0.4 REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G Genes involved in Vif-mediated degradation of APOBEC3G
0.0 1.4 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.9 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.0 1.2 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 0.8 REACTOME RNA POL III TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.0 0.4 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.0 1.1 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 1.2 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.0 0.6 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.7 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 1.1 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.3 REACTOME INFLAMMASOMES Genes involved in Inflammasomes