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SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for IRF9

Z-value: 1.99

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Transcription factors associated with IRF9

Gene Symbol Gene ID Gene Info
IRF9
ENSG00000213928.4 interferon regulatory factor 9

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
IRF9hg19_v2_chr14_+_24630465_246305310.751.3e-04Click!

Activity profile of IRF9 motif

Sorted Z-values of IRF9 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_948803 11.35 ENST00000379389.4
ISG15
ISG15 ubiquitin-like modifier
chr21_+_42798094 9.98 ENST00000398598.3
ENST00000455164.2
ENST00000424365.1
MX1
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr11_-_615570 6.53 ENST00000525445.1
ENST00000348655.6
ENST00000397566.1
IRF7
interferon regulatory factor 7
chr12_-_121477039 6.52 ENST00000257570.5
OASL
2'-5'-oligoadenylate synthetase-like
chr11_-_615942 6.20 ENST00000397562.3
ENST00000330243.5
ENST00000397570.1
ENST00000397574.2
IRF7
interferon regulatory factor 7
chr21_+_42798158 6.10 ENST00000441677.1
MX1
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr21_+_42798124 6.09 ENST00000417963.1
MX1
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr12_-_121476959 6.08 ENST00000339275.5
OASL
2'-5'-oligoadenylate synthetase-like
chr21_+_42797958 5.84 ENST00000419044.1
MX1
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr12_+_113344582 5.31 ENST00000202917.5
ENST00000445409.2
ENST00000452357.2
OAS1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr12_+_113344811 4.72 ENST00000551241.1
ENST00000553185.1
ENST00000550689.1
OAS1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr2_-_7005785 4.68 ENST00000256722.5
ENST00000404168.1
ENST00000458098.1
CMPK2
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
chr17_+_6659153 4.58 ENST00000441631.1
ENST00000438512.1
ENST00000346752.4
ENST00000361842.3
XAF1
XIAP associated factor 1
chr1_+_79115503 4.44 ENST00000370747.4
ENST00000438486.1
ENST00000545124.1
IFI44
interferon-induced protein 44
chr12_+_113344755 4.40 ENST00000550883.1
OAS1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr14_+_94577074 4.32 ENST00000444961.1
ENST00000448882.1
ENST00000557098.1
ENST00000554800.1
ENST00000556544.1
ENST00000298902.5
ENST00000555819.1
ENST00000557634.1
ENST00000555744.1
IFI27
interferon, alpha-inducible protein 27
chr9_-_32526184 3.98 ENST00000545044.1
ENST00000379868.1
DDX58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr1_+_79086088 3.86 ENST00000370751.5
ENST00000342282.3
IFI44L
interferon-induced protein 44-like
chr10_+_91092241 3.77 ENST00000371811.4
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr19_-_17516449 3.58 ENST00000252593.6
BST2
bone marrow stromal cell antigen 2
chr21_+_42733870 3.55 ENST00000330714.3
ENST00000436410.1
ENST00000435611.1
MX2
myxovirus (influenza virus) resistance 2 (mouse)
chr12_-_121476750 3.42 ENST00000543677.1
OASL
2'-5'-oligoadenylate synthetase-like
chr22_+_18632666 3.06 ENST00000215794.7
USP18
ubiquitin specific peptidase 18
chr3_-_122283100 2.86 ENST00000492382.1
ENST00000462315.1
PARP9
poly (ADP-ribose) polymerase family, member 9
chr1_-_150738261 2.80 ENST00000448301.2
ENST00000368985.3
CTSS
cathepsin S
chr9_-_32526299 2.78 ENST00000379882.1
ENST00000379883.2
DDX58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr19_+_16254488 2.71 ENST00000588246.1
ENST00000593031.1
HSH2D
hematopoietic SH2 domain containing
chr12_+_113376249 2.66 ENST00000551007.1
ENST00000548514.1
OAS3
2'-5'-oligoadenylate synthetase 3, 100kDa
chr2_-_163175133 2.65 ENST00000421365.2
ENST00000263642.2
IFIH1
interferon induced with helicase C domain 1
chr3_-_122283424 2.58 ENST00000477522.2
ENST00000360356.2
PARP9
poly (ADP-ribose) polymerase family, member 9
chr14_+_24630465 2.53 ENST00000557894.1
ENST00000559284.1
ENST00000560275.1
IRF9
interferon regulatory factor 9
chr3_-_122283079 2.50 ENST00000471785.1
ENST00000466126.1
PARP9
poly (ADP-ribose) polymerase family, member 9
chr12_+_113376157 2.37 ENST00000228928.7
OAS3
2'-5'-oligoadenylate synthetase 3, 100kDa
chr4_+_89378261 2.10 ENST00000264350.3
HERC5
HECT and RLD domain containing E3 ubiquitin protein ligase 5
chr3_-_146262365 2.02 ENST00000448787.2
PLSCR1
phospholipid scramblase 1
chr10_+_91061712 2.01 ENST00000371826.3
IFIT2
interferon-induced protein with tetratricopeptide repeats 2
chr2_-_55920952 1.96 ENST00000447944.2
PNPT1
polyribonucleotide nucleotidyltransferase 1
chr3_-_146262293 1.90 ENST00000448205.1
PLSCR1
phospholipid scramblase 1
chr3_-_146262428 1.83 ENST00000486631.1
PLSCR1
phospholipid scramblase 1
chr19_+_10196981 1.79 ENST00000591813.1
C19orf66
chromosome 19 open reading frame 66
chr3_-_146262352 1.76 ENST00000462666.1
PLSCR1
phospholipid scramblase 1
chr3_-_146262637 1.67 ENST00000472349.1
ENST00000342435.4
PLSCR1
phospholipid scramblase 1
chr3_-_146262488 1.66 ENST00000487389.1
PLSCR1
phospholipid scramblase 1
chr17_-_54991395 1.62 ENST00000316881.4
TRIM25
tripartite motif containing 25
chr11_+_5646213 1.58 ENST00000429814.2
TRIM34
tripartite motif containing 34
chr6_-_31324943 1.56 ENST00000412585.2
ENST00000434333.1
HLA-B
major histocompatibility complex, class I, B
chr17_+_6659354 1.54 ENST00000574907.1
XAF1
XIAP associated factor 1
chr7_+_134832808 1.53 ENST00000275767.3
TMEM140
transmembrane protein 140
chr2_-_152146385 1.52 ENST00000414946.1
ENST00000243346.5
NMI
N-myc (and STAT) interactor
chr4_-_169401628 1.51 ENST00000514748.1
ENST00000512371.1
ENST00000260184.7
ENST00000505890.1
ENST00000511577.1
DDX60L
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like
chr2_+_7005959 1.47 ENST00000442639.1
RSAD2
radical S-adenosyl methionine domain containing 2
chr12_-_56753858 1.45 ENST00000314128.4
ENST00000557235.1
ENST00000418572.2
STAT2
signal transducer and activator of transcription 2, 113kDa
chr15_+_74287035 1.35 ENST00000395132.2
ENST00000268059.6
ENST00000354026.6
ENST00000268058.3
ENST00000565898.1
ENST00000569477.1
ENST00000569965.1
ENST00000567543.1
ENST00000436891.3
ENST00000435786.2
ENST00000564428.1
ENST00000359928.4
PML
promyelocytic leukemia
chr3_+_122283064 1.28 ENST00000296161.4
DTX3L
deltex 3-like (Drosophila)
chr16_-_74734672 1.27 ENST00000306247.7
ENST00000575686.1
MLKL
mixed lineage kinase domain-like
chr15_-_26108355 1.26 ENST00000356865.6
ATP10A
ATPase, class V, type 10A
chr10_+_91174314 1.15 ENST00000371795.4
IFIT5
interferon-induced protein with tetratricopeptide repeats 5
chr11_-_57335280 1.12 ENST00000287156.4
UBE2L6
ubiquitin-conjugating enzyme E2L 6
chr6_+_126240442 1.12 ENST00000448104.1
ENST00000438495.1
ENST00000444128.1
NCOA7
nuclear receptor coactivator 7
chr17_+_6658878 1.06 ENST00000574394.1
XAF1
XIAP associated factor 1
chr11_-_4414880 0.98 ENST00000254436.7
ENST00000543625.1
TRIM21
tripartite motif containing 21
chr11_-_67141090 0.97 ENST00000312438.7
CLCF1
cardiotrophin-like cytokine factor 1
chr15_+_74287118 0.96 ENST00000563500.1
PML
promyelocytic leukemia
chr2_+_7017796 0.94 ENST00000382040.3
RSAD2
radical S-adenosyl methionine domain containing 2
chr11_-_57334732 0.85 ENST00000526659.1
ENST00000527022.1
UBE2L6
ubiquitin-conjugating enzyme E2L 6
chr13_+_50070077 0.82 ENST00000378319.3
ENST00000426879.1
PHF11
PHD finger protein 11
chr3_+_187086120 0.80 ENST00000259030.2
RTP4
receptor (chemosensory) transporter protein 4
chr1_+_66820058 0.78 ENST00000480109.2
PDE4B
phosphodiesterase 4B, cAMP-specific
chr10_+_91174486 0.77 ENST00000416601.1
IFIT5
interferon-induced protein with tetratricopeptide repeats 5
chr3_+_122399444 0.73 ENST00000474629.2
PARP14
poly (ADP-ribose) polymerase family, member 14
chr2_-_106810783 0.71 ENST00000283148.7
UXS1
UDP-glucuronate decarboxylase 1
chr8_+_39770803 0.70 ENST00000518237.1
IDO1
indoleamine 2,3-dioxygenase 1
chr20_+_61436146 0.66 ENST00000290291.6
OGFR
opioid growth factor receptor
chr17_+_79373540 0.66 ENST00000307745.7
RP11-1055B8.7
BAH and coiled-coil domain-containing protein 1
chr2_+_163175394 0.64 ENST00000446271.1
ENST00000429691.2
GCA
grancalcin, EF-hand calcium binding protein
chr4_-_169239921 0.59 ENST00000514995.1
ENST00000393743.3
DDX60
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
chr13_+_50070491 0.56 ENST00000496612.1
ENST00000357596.3
ENST00000485919.1
ENST00000442195.1
PHF11
PHD finger protein 11
chr1_+_158979680 0.56 ENST00000368131.4
ENST00000340979.6
IFI16
interferon, gamma-inducible protein 16
chr12_+_6881678 0.53 ENST00000441671.2
ENST00000203629.2
LAG3
lymphocyte-activation gene 3
chr6_-_32806483 0.52 ENST00000374899.4
TAP2
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
chr6_-_32806506 0.51 ENST00000374897.2
ENST00000452392.2
TAP2
TAP2
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
Uncharacterized protein
chr2_+_33701707 0.51 ENST00000425210.1
ENST00000444784.1
ENST00000423159.1
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr1_+_158979686 0.49 ENST00000368132.3
ENST00000295809.7
IFI16
interferon, gamma-inducible protein 16
chr1_+_158979792 0.49 ENST00000359709.3
ENST00000430894.2
IFI16
interferon, gamma-inducible protein 16
chr17_+_78234625 0.49 ENST00000508628.2
ENST00000582970.1
ENST00000456466.1
ENST00000319921.4
RNF213
ring finger protein 213
chr2_-_37384175 0.49 ENST00000411537.2
ENST00000233057.4
ENST00000395127.2
ENST00000390013.3
EIF2AK2
eukaryotic translation initiation factor 2-alpha kinase 2
chr16_+_28875126 0.46 ENST00000359285.5
ENST00000538342.1
SH2B1
SH2B adaptor protein 1
chr2_-_106810742 0.45 ENST00000409501.3
ENST00000428048.2
ENST00000441952.1
ENST00000457835.1
ENST00000540130.1
UXS1
UDP-glucuronate decarboxylase 1
chr6_-_33282163 0.39 ENST00000434618.2
ENST00000456592.2
TAPBP
TAP binding protein (tapasin)
chr6_+_37400974 0.38 ENST00000455891.1
ENST00000373451.4
CMTR1
cap methyltransferase 1
chr15_+_58702742 0.37 ENST00000356113.6
ENST00000414170.3
LIPC
lipase, hepatic
chr4_-_76944621 0.37 ENST00000306602.1
CXCL10
chemokine (C-X-C motif) ligand 10
chr16_+_28875268 0.34 ENST00000395532.4
SH2B1
SH2B adaptor protein 1
chr9_+_74764340 0.34 ENST00000376986.1
ENST00000358399.3
GDA
guanine deaminase
chr15_+_91643442 0.34 ENST00000394232.1
SV2B
synaptic vesicle glycoprotein 2B
chr19_+_10222189 0.31 ENST00000321826.4
P2RY11
purinergic receptor P2Y, G-protein coupled, 11
chr17_-_4167142 0.28 ENST00000570535.1
ENST00000574367.1
ENST00000341657.4
ENST00000433651.1
ANKFY1
ankyrin repeat and FYVE domain containing 1
chr3_+_159706537 0.28 ENST00000305579.2
ENST00000480787.1
ENST00000466512.1
IL12A
interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)
chr6_-_110736742 0.28 ENST00000368924.3
ENST00000368923.3
DDO
D-aspartate oxidase
chr18_-_25616519 0.27 ENST00000399380.3
CDH2
cadherin 2, type 1, N-cadherin (neuronal)
chr9_+_74764278 0.26 ENST00000238018.4
ENST00000376989.3
GDA
guanine deaminase
chrX_-_48858630 0.24 ENST00000376425.3
ENST00000376444.3
GRIPAP1
GRIP1 associated protein 1
chr18_-_67624412 0.22 ENST00000580335.1
CD226
CD226 molecule
chr18_-_67623906 0.21 ENST00000583955.1
CD226
CD226 molecule
chr6_-_8102714 0.21 ENST00000502429.1
ENST00000429723.2
ENST00000507463.1
ENST00000379715.5
EEF1E1
eukaryotic translation elongation factor 1 epsilon 1
chr6_+_106546808 0.20 ENST00000369089.3
PRDM1
PR domain containing 1, with ZNF domain
chr20_-_56195525 0.19 ENST00000371173.3
ENST00000395822.3
ENST00000340462.4
ENST00000343535.4
ZBP1
Z-DNA binding protein 1
chr1_+_162602244 0.19 ENST00000367922.3
ENST00000367921.3
DDR2
discoidin domain receptor tyrosine kinase 2
chr6_-_82462425 0.18 ENST00000369754.3
ENST00000320172.6
ENST00000369756.3
FAM46A
family with sequence similarity 46, member A
chr16_+_53412368 0.18 ENST00000565189.1
RP11-44F14.2
RP11-44F14.2
chrX_-_48858667 0.17 ENST00000376423.4
ENST00000376441.1
GRIPAP1
GRIP1 associated protein 1
chr3_-_130745403 0.17 ENST00000504725.1
ENST00000509060.1
ASTE1
asteroid homolog 1 (Drosophila)
chr17_-_54991369 0.15 ENST00000537230.1
TRIM25
tripartite motif containing 25
chr19_-_12807422 0.14 ENST00000380339.3
ENST00000544494.1
ENST00000393261.3
FBXW9
F-box and WD repeat domain containing 9
chr15_+_74287009 0.14 ENST00000395135.3
PML
promyelocytic leukemia
chr15_+_45003675 0.13 ENST00000558401.1
ENST00000559916.1
ENST00000544417.1
B2M
beta-2-microglobulin
chr22_+_40297079 0.11 ENST00000344138.4
ENST00000543252.1
GRAP2
GRB2-related adaptor protein 2
chr1_+_110993795 0.10 ENST00000271331.3
PROK1
prokineticin 1
chr16_+_28962128 0.09 ENST00000564978.1
ENST00000320805.4
NFATC2IP
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein
chr5_-_59481406 0.08 ENST00000546160.1
PDE4D
phosphodiesterase 4D, cAMP-specific
chr1_+_59486059 0.07 ENST00000447329.1
RP4-794H19.4
RP4-794H19.4
chr4_-_147442982 0.06 ENST00000511374.1
ENST00000264986.3
SLC10A7
solute carrier family 10, member 7
chr6_+_72922590 0.04 ENST00000523963.1
RIMS1
regulating synaptic membrane exocytosis 1
chr3_-_28390120 0.03 ENST00000334100.6
AZI2
5-azacytidine induced 2
chr9_-_33264676 0.03 ENST00000472232.3
ENST00000379704.2
BAG1
BCL2-associated athanogene
chr6_+_72922505 0.03 ENST00000401910.3
RIMS1
regulating synaptic membrane exocytosis 1
chr18_-_67624160 0.03 ENST00000581982.1
ENST00000280200.4
CD226
CD226 molecule
chrX_+_37639302 0.02 ENST00000545017.1
ENST00000536160.1
CYBB
cytochrome b-245, beta polypeptide
chr6_-_24936170 0.02 ENST00000538035.1
FAM65B
family with sequence similarity 65, member B
chr1_-_234667504 0.00 ENST00000421207.1
ENST00000435574.1
RP5-855F14.1
RP5-855F14.1

Network of associatons between targets according to the STRING database.

First level regulatory network of IRF9

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 12.7 GO:2000110 negative regulation of macrophage apoptotic process(GO:2000110)
2.3 9.0 GO:0034344 type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344)
1.5 31.5 GO:0003373 dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374)
1.3 15.4 GO:0032020 ISG15-protein conjugation(GO:0032020)
1.2 3.6 GO:1901253 negative regulation of dendritic cell cytokine production(GO:0002731) negative regulation of intracellular transport of viral material(GO:1901253)
1.2 4.7 GO:0009138 pyrimidine nucleoside diphosphate metabolic process(GO:0009138)
1.1 10.8 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659) regulation of isomerase activity(GO:0010911) positive regulation of isomerase activity(GO:0010912) regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000371) positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000373)
0.7 8.0 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.7 2.0 GO:2000627 rRNA import into mitochondrion(GO:0035928) regulation of miRNA catabolic process(GO:2000625) positive regulation of miRNA catabolic process(GO:2000627)
0.5 1.0 GO:0002476 antigen processing and presentation of endogenous peptide antigen via MHC class Ib(GO:0002476)
0.5 62.1 GO:0060337 type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357)
0.4 1.2 GO:0033319 UDP-D-xylose metabolic process(GO:0033319) UDP-D-xylose biosynthetic process(GO:0033320)
0.3 2.4 GO:0030578 PML body organization(GO:0030578)
0.3 1.5 GO:0045354 interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354)
0.3 2.7 GO:0051902 negative regulation of mitochondrial depolarization(GO:0051902)
0.2 1.0 GO:0090086 negative regulation of protein deubiquitination(GO:0090086)
0.2 0.6 GO:0006147 guanine catabolic process(GO:0006147)
0.2 0.7 GO:0036269 swimming behavior(GO:0036269)
0.1 0.1 GO:0002428 antigen processing and presentation of peptide antigen via MHC class Ib(GO:0002428)
0.1 0.4 GO:0036451 cap mRNA methylation(GO:0036451)
0.1 1.0 GO:0048295 positive regulation of isotype switching to IgE isotypes(GO:0048295)
0.1 0.5 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.1 0.3 GO:0046416 D-amino acid metabolic process(GO:0046416)
0.1 1.8 GO:1902187 negative regulation of viral release from host cell(GO:1902187)
0.1 0.5 GO:0045085 negative regulation of interleukin-2 biosynthetic process(GO:0045085)
0.1 2.5 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.1 0.5 GO:0002729 positive regulation of natural killer cell cytokine production(GO:0002729)
0.1 0.2 GO:1990654 sebum secreting cell proliferation(GO:1990654)
0.1 3.9 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.1 0.9 GO:1901078 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 0.7 GO:0038003 opioid receptor signaling pathway(GO:0038003)
0.1 0.4 GO:1905244 regulation of modification of synaptic structure(GO:1905244)
0.0 1.1 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.0 0.4 GO:0010819 regulation of T cell chemotaxis(GO:0010819)
0.0 0.3 GO:0002857 positive regulation of natural killer cell mediated immune response to tumor cell(GO:0002857) positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002860)
0.0 1.3 GO:0045332 phospholipid translocation(GO:0045332)
0.0 0.3 GO:0048549 endosome localization(GO:0032439) positive regulation of pinocytosis(GO:0048549)
0.0 2.9 GO:0070206 protein trimerization(GO:0070206)
0.0 0.3 GO:2000809 regulation of postsynaptic density protein 95 clustering(GO:1902897) positive regulation of synaptic vesicle clustering(GO:2000809)
0.0 0.4 GO:0034372 very-low-density lipoprotein particle remodeling(GO:0034372)
0.0 0.1 GO:1900245 positive regulation of MDA-5 signaling pathway(GO:1900245)
0.0 0.3 GO:0023041 neuronal signal transduction(GO:0023041)
0.0 7.0 GO:0009615 response to virus(GO:0009615)
0.0 0.2 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.8 GO:0036021 endolysosome lumen(GO:0036021)
0.3 2.4 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.2 1.0 GO:0097058 CRLF-CLCF1 complex(GO:0097058) CNTFR-CLCF1 complex(GO:0097059)
0.2 1.7 GO:0042612 MHC class I protein complex(GO:0042612)
0.2 2.0 GO:0042788 polysomal ribosome(GO:0042788)
0.1 0.3 GO:0031906 late endosome lumen(GO:0031906)
0.1 0.7 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.1 1.9 GO:0008385 IkappaB kinase complex(GO:0008385)
0.1 0.5 GO:0042825 TAP complex(GO:0042825)
0.1 0.4 GO:0098837 postsynaptic recycling endosome(GO:0098837)
0.0 3.6 GO:0005771 multivesicular body(GO:0005771)
0.0 28.0 GO:0031965 nuclear membrane(GO:0031965)
0.0 3.3 GO:0005643 nuclear pore(GO:0005643)
0.0 6.8 GO:0032587 ruffle membrane(GO:0032587)
0.0 0.3 GO:0044354 pinosome(GO:0044352) macropinosome(GO:0044354)
0.0 0.8 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 2.4 GO:0005811 lipid particle(GO:0005811)
0.0 27.8 GO:0005730 nucleolus(GO:0005730)
0.0 0.3 GO:0016342 catenin complex(GO:0016342)
0.0 8.6 GO:0010008 endosome membrane(GO:0010008)
0.0 32.0 GO:0005739 mitochondrion(GO:0005739)
0.0 0.9 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.3 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
3.0 35.5 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
1.2 4.7 GO:0009041 uridylate kinase activity(GO:0009041)
0.9 11.4 GO:0031386 protein tag(GO:0031386)
0.5 10.8 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.4 4.1 GO:0042296 ISG15 transferase activity(GO:0042296)
0.4 1.2 GO:0048040 UDP-glucuronate decarboxylase activity(GO:0048040)
0.3 8.0 GO:0070403 NAD+ binding(GO:0070403)
0.3 2.0 GO:0034046 poly(G) binding(GO:0034046)
0.2 0.6 GO:0008892 guanine deaminase activity(GO:0008892)
0.2 0.7 GO:0033754 indoleamine 2,3-dioxygenase activity(GO:0033754)
0.2 0.8 GO:0031849 olfactory receptor binding(GO:0031849)
0.1 0.4 GO:0004483 mRNA (nucleoside-2'-O-)-methyltransferase activity(GO:0004483)
0.1 3.6 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 1.0 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.1 0.5 GO:0015433 peptide antigen-transporting ATPase activity(GO:0015433)
0.1 4.3 GO:0005521 lamin binding(GO:0005521)
0.1 0.4 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.1 0.5 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.1 11.5 GO:0003727 single-stranded RNA binding(GO:0003727)
0.1 1.8 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.1 0.5 GO:0042289 MHC class II protein binding(GO:0042289)
0.1 31.5 GO:0008017 microtubule binding(GO:0008017)
0.1 0.7 GO:0004985 opioid receptor activity(GO:0004985)
0.1 2.8 GO:0043394 proteoglycan binding(GO:0043394)
0.1 9.1 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.1 0.1 GO:0003726 double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0 1.3 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 2.4 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.0 1.6 GO:0042605 peptide antigen binding(GO:0042605)
0.0 0.3 GO:0005143 interleukin-12 receptor binding(GO:0005143)
0.0 0.3 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.0 0.8 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 3.1 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0 2.5 GO:0001047 core promoter binding(GO:0001047)
0.0 2.8 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.4 GO:0034185 apolipoprotein binding(GO:0034185)
0.0 0.6 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.8 GO:0035591 signaling adaptor activity(GO:0035591)
0.0 2.2 GO:0046332 SMAD binding(GO:0046332)
0.0 1.1 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 0.2 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.0 0.4 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.3 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 0.3 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 4.0 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.0 9.4 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 1.4 SIG PIP3 SIGNALING IN B LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.0 2.4 PID TGFBR PATHWAY TGF-beta receptor signaling
0.0 1.6 SIG PIP3 SIGNALING IN CARDIAC MYOCTES Genes related to PIP3 signaling in cardiac myocytes

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 115.3 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.7 2.9 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.7 11.2 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.1 4.1 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 1.0 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 2.4 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 0.6 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.0 0.8 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.0 0.1 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
0.0 1.3 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.4 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.3 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 0.9 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events