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SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for IRX6_IRX4

Z-value: 0.50

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Transcription factors associated with IRX6_IRX4

Gene Symbol Gene ID Gene Info
IRX6
ENSG00000159387.7 iroquois homeobox 6
IRX4
ENSG00000113430.5 iroquois homeobox 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
IRX4hg19_v2_chr5_-_1882858_1883003-0.723.3e-04Click!
IRX6hg19_v2_chr16_+_55357672_553576720.019.6e-01Click!

Activity profile of IRX6_IRX4 motif

Sorted Z-values of IRX6_IRX4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr7_-_16844611 1.62 ENST00000401412.1
ENST00000419304.2
AGR2
anterior gradient 2
chr11_+_114166536 1.37 ENST00000299964.3
NNMT
nicotinamide N-methyltransferase
chr15_-_63448973 1.27 ENST00000462430.1
RPS27L
ribosomal protein S27-like
chr4_+_141264597 1.15 ENST00000338517.4
ENST00000394203.3
ENST00000506322.1
SCOC
short coiled-coil protein
chr20_+_10199468 1.07 ENST00000254976.2
ENST00000304886.2
SNAP25
synaptosomal-associated protein, 25kDa
chr3_-_124606502 0.98 ENST00000483168.1
ITGB5
integrin, beta 5
chr10_+_90660832 0.83 ENST00000371924.1
STAMBPL1
STAM binding protein-like 1
chr3_+_53528659 0.82 ENST00000350061.5
CACNA1D
calcium channel, voltage-dependent, L type, alpha 1D subunit
chr4_+_41361616 0.78 ENST00000513024.1
LIMCH1
LIM and calponin homology domains 1
chr1_-_201438282 0.77 ENST00000367311.3
ENST00000367309.1
PHLDA3
pleckstrin homology-like domain, family A, member 3
chr8_-_17555164 0.70 ENST00000297488.6
MTUS1
microtubule associated tumor suppressor 1
chr16_+_776936 0.69 ENST00000549114.1
ENST00000341413.4
ENST00000562187.1
ENST00000564537.1
HAGHL
hydroxyacylglutathione hydrolase-like
chr16_+_777246 0.67 ENST00000561546.1
ENST00000564545.1
ENST00000389703.3
ENST00000567414.1
ENST00000568141.1
HAGHL
hydroxyacylglutathione hydrolase-like
chr15_+_66585879 0.66 ENST00000319212.4
DIS3L
DIS3 mitotic control homolog (S. cerevisiae)-like
chr15_+_66585555 0.63 ENST00000319194.5
ENST00000525134.2
ENST00000441424.2
DIS3L
DIS3 mitotic control homolog (S. cerevisiae)-like
chr17_+_38673270 0.63 ENST00000578280.1
RP5-1028K7.2
RP5-1028K7.2
chrX_-_135962923 0.60 ENST00000565438.1
RBMX
RNA binding motif protein, X-linked
chr3_-_9994021 0.58 ENST00000411976.2
ENST00000412055.1
PRRT3
proline-rich transmembrane protein 3
chr12_-_76462713 0.52 ENST00000552056.1
NAP1L1
nucleosome assembly protein 1-like 1
chr8_+_27631903 0.49 ENST00000305188.8
ESCO2
establishment of sister chromatid cohesion N-acetyltransferase 2
chr1_-_89641680 0.48 ENST00000294671.2
GBP7
guanylate binding protein 7
chr19_-_54974894 0.48 ENST00000333834.4
LENG9
leukocyte receptor cluster (LRC) member 9
chr20_+_10199566 0.44 ENST00000430336.1
SNAP25
synaptosomal-associated protein, 25kDa
chr16_+_777739 0.38 ENST00000563792.1
HAGHL
hydroxyacylglutathione hydrolase-like
chr2_-_231989808 0.37 ENST00000258400.3
HTR2B
5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
chr12_-_123728548 0.35 ENST00000545406.1
MPHOSPH9
M-phase phosphoprotein 9
chr6_-_33679452 0.34 ENST00000374231.4
ENST00000607484.1
ENST00000374214.3
UQCC2
ubiquinol-cytochrome c reductase complex assembly factor 2
chr1_-_3566590 0.33 ENST00000424367.1
ENST00000378322.3
WRAP73
WD repeat containing, antisense to TP73
chr1_+_53308398 0.33 ENST00000371528.1
ZYG11A
zyg-11 family member A, cell cycle regulator
chr1_+_220267429 0.32 ENST00000366922.1
ENST00000302637.5
IARS2
isoleucyl-tRNA synthetase 2, mitochondrial
chr21_-_34185944 0.32 ENST00000479548.1
C21orf62
chromosome 21 open reading frame 62
chr1_-_3566627 0.32 ENST00000419924.2
ENST00000270708.7
WRAP73
WD repeat containing, antisense to TP73
chr1_+_212475148 0.30 ENST00000537030.3
PPP2R5A
protein phosphatase 2, regulatory subunit B', alpha
chr4_-_104119528 0.27 ENST00000380026.3
ENST00000503705.1
ENST00000265148.3
CENPE
centromere protein E, 312kDa
chr12_+_53848549 0.27 ENST00000439930.3
ENST00000548933.1
ENST00000562264.1
PCBP2
poly(rC) binding protein 2
chr6_+_149887377 0.27 ENST00000367419.5
GINM1
glycoprotein integral membrane 1
chr21_-_34185989 0.26 ENST00000487113.1
ENST00000382373.4
C21orf62
chromosome 21 open reading frame 62
chr21_-_34186006 0.26 ENST00000490358.1
C21orf62
chromosome 21 open reading frame 62
chr14_+_56127989 0.25 ENST00000555573.1
KTN1
kinectin 1 (kinesin receptor)
chr20_+_43990576 0.23 ENST00000372727.1
ENST00000414310.1
SYS1
SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae)
chr16_+_777118 0.23 ENST00000562141.1
HAGHL
hydroxyacylglutathione hydrolase-like
chr4_-_104119488 0.23 ENST00000514974.1
CENPE
centromere protein E, 312kDa
chr5_+_169758393 0.21 ENST00000521471.1
ENST00000518357.1
ENST00000436248.3
CTB-114C7.3
CTB-114C7.3
chr15_+_54901540 0.20 ENST00000539562.2
UNC13C
unc-13 homolog C (C. elegans)
chr11_+_61891445 0.19 ENST00000394818.3
ENST00000533896.1
ENST00000278849.4
INCENP
inner centromere protein antigens 135/155kDa
chr3_+_186158169 0.18 ENST00000435548.1
ENST00000421006.1
RP11-78H24.1
RP11-78H24.1
chr8_-_74495065 0.18 ENST00000523533.1
STAU2
staufen double-stranded RNA binding protein 2
chr11_+_110225855 0.17 ENST00000526605.1
ENST00000526703.1
RP11-347E10.1
RP11-347E10.1
chr15_+_41057818 0.17 ENST00000558467.1
GCHFR
GTP cyclohydrolase I feedback regulator
chr17_-_6524159 0.16 ENST00000589033.1
KIAA0753
KIAA0753
chr14_-_68159152 0.15 ENST00000554035.1
RDH11
retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
chr1_-_149859466 0.15 ENST00000331128.3
HIST2H2AB
histone cluster 2, H2ab
chr18_-_56985776 0.14 ENST00000587244.1
CPLX4
complexin 4
chr14_+_56127960 0.14 ENST00000553624.1
KTN1
kinectin 1 (kinesin receptor)
chr17_-_47723943 0.11 ENST00000510476.1
ENST00000503676.1
SPOP
speckle-type POZ protein
chr22_-_24096562 0.11 ENST00000398465.3
VPREB3
pre-B lymphocyte 3
chr3_+_68053359 0.10 ENST00000478136.1
FAM19A1
family with sequence similarity 19 (chemokine (C-C motif)-like), member A1
chr17_-_42327236 0.09 ENST00000399246.2
AC003102.1
AC003102.1
chrX_+_36254051 0.09 ENST00000378657.4
CXorf30
chromosome X open reading frame 30
chr4_+_158142750 0.08 ENST00000505888.1
ENST00000449365.1
GRIA2
glutamate receptor, ionotropic, AMPA 2
chr3_-_27498235 0.07 ENST00000295736.5
ENST00000428386.1
ENST00000428179.1
SLC4A7
solute carrier family 4, sodium bicarbonate cotransporter, member 7
chr2_+_133874577 0.07 ENST00000596384.1
AC011755.1
HCG2006742; Protein LOC100996685
chr8_-_67976509 0.07 ENST00000518747.1
COPS5
COP9 signalosome subunit 5
chr7_-_55583740 0.06 ENST00000453256.1
VOPP1
vesicular, overexpressed in cancer, prosurvival protein 1
chr7_-_92855762 0.06 ENST00000453812.2
ENST00000394468.2
HEPACAM2
HEPACAM family member 2
chr2_-_183106641 0.06 ENST00000346717.4
PDE1A
phosphodiesterase 1A, calmodulin-dependent
chr2_+_113670548 0.06 ENST00000263326.3
ENST00000352179.3
ENST00000349806.3
ENST00000353225.3
IL37
interleukin 37
chr5_+_175490540 0.06 ENST00000515817.1
FAM153B
family with sequence similarity 153, member B
chr2_+_58655520 0.05 ENST00000455219.3
ENST00000449448.2
AC007092.1
long intergenic non-protein coding RNA 1122
chrX_+_47867194 0.05 ENST00000376940.3
SPACA5
sperm acrosome associated 5
chr3_-_139199565 0.05 ENST00000511956.1
RBP2
retinol binding protein 2, cellular
chr3_-_139199589 0.05 ENST00000506825.1
RBP2
retinol binding protein 2, cellular
chrX_-_19988382 0.05 ENST00000356980.3
ENST00000379687.3
ENST00000379682.4
CXorf23
chromosome X open reading frame 23
chr9_-_37465396 0.05 ENST00000307750.4
ZBTB5
zinc finger and BTB domain containing 5
chr12_-_10282836 0.05 ENST00000304084.8
ENST00000353231.5
ENST00000525605.1
CLEC7A
C-type lectin domain family 7, member A
chr7_+_23210760 0.04 ENST00000366347.4
AC005082.1
Uncharacterized protein
chr8_+_67976593 0.04 ENST00000262210.5
ENST00000412460.1
CSPP1
centrosome and spindle pole associated protein 1
chr18_-_70305745 0.04 ENST00000581073.1
CBLN2
cerebellin 2 precursor
chrX_+_15767971 0.04 ENST00000479740.1
ENST00000454127.2
CA5B
carbonic anhydrase VB, mitochondrial
chr13_-_41768654 0.03 ENST00000379483.3
KBTBD7
kelch repeat and BTB (POZ) domain containing 7
chr4_-_177190364 0.03 ENST00000296525.3
ASB5
ankyrin repeat and SOCS box containing 5
chr7_+_871559 0.03 ENST00000421580.1
SUN1
Sad1 and UNC84 domain containing 1
chr5_-_177207634 0.03 ENST00000513554.1
ENST00000440605.3
FAM153A
family with sequence similarity 153, member A
chrX_-_15333736 0.02 ENST00000380470.3
ASB11
ankyrin repeat and SOCS box containing 11
chr2_-_238333919 0.02 ENST00000409162.1
AC112721.1
Uncharacterized protein
chr1_+_170904612 0.02 ENST00000367759.4
ENST00000367758.3
MROH9
maestro heat-like repeat family member 9
chr15_-_51630772 0.02 ENST00000557858.1
ENST00000558328.1
ENST00000396404.4
ENST00000561075.1
ENST00000405011.2
ENST00000559980.1
ENST00000453807.2
ENST00000396402.1
CYP19A1
cytochrome P450, family 19, subfamily A, polypeptide 1
chr17_-_29641084 0.02 ENST00000544462.1
EVI2B
ecotropic viral integration site 2B
chr19_-_48059113 0.02 ENST00000391901.3
ENST00000314121.4
ENST00000448976.1
ZNF541
zinc finger protein 541
chr19_+_50691437 0.01 ENST00000598205.1
MYH14
myosin, heavy chain 14, non-muscle
chr18_-_46784778 0.01 ENST00000582399.1
DYM
dymeclin
chr4_+_71458012 0.01 ENST00000449493.2
AMBN
ameloblastin (enamel matrix protein)
chr4_+_158141899 0.00 ENST00000264426.9
ENST00000506284.1
GRIA2
glutamate receptor, ionotropic, AMPA 2
chr4_+_71457970 0.00 ENST00000322937.6
AMBN
ameloblastin (enamel matrix protein)

Network of associatons between targets according to the STRING database.

First level regulatory network of IRX6_IRX4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.5 GO:1990926 short-term synaptic potentiation(GO:1990926)
0.2 1.6 GO:1903899 lung goblet cell differentiation(GO:0060480) positive regulation of PERK-mediated unfolded protein response(GO:1903899)
0.1 0.8 GO:0060372 regulation of atrial cardiac muscle cell membrane repolarization(GO:0060372)
0.1 0.4 GO:0010513 positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
0.1 0.5 GO:0034421 post-translational protein acetylation(GO:0034421)
0.1 0.3 GO:0006428 isoleucyl-tRNA aminoacylation(GO:0006428)
0.1 0.5 GO:0007079 mitotic chromosome movement towards spindle pole(GO:0007079)
0.1 1.2 GO:0061635 regulation of protein complex stability(GO:0061635)
0.1 1.4 GO:0034356 NAD biosynthesis via nicotinamide riboside salvage pathway(GO:0034356)
0.1 0.2 GO:0043105 regulation of GTP cyclohydrolase I activity(GO:0043095) negative regulation of GTP cyclohydrolase I activity(GO:0043105)
0.1 1.3 GO:0016075 rRNA catabolic process(GO:0016075)
0.1 1.3 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.0 0.3 GO:0090219 negative regulation of lipid kinase activity(GO:0090219)
0.0 0.2 GO:0016062 adaptation of rhodopsin mediated signaling(GO:0016062) light adaption(GO:0036367)
0.0 0.3 GO:0017062 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.0 1.0 GO:0090136 epithelial cell-cell adhesion(GO:0090136)
0.0 0.2 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.0 0.6 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.0 0.6 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.0 0.8 GO:0070536 protein K63-linked deubiquitination(GO:0070536)
0.0 0.1 GO:2000676 positive regulation of type B pancreatic cell apoptotic process(GO:2000676)
0.0 0.3 GO:0075522 IRES-dependent viral translational initiation(GO:0075522)
0.0 0.8 GO:0051898 negative regulation of protein kinase B signaling(GO:0051898)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 GO:0034684 integrin alphav-beta5 complex(GO:0034684)
0.2 1.5 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
0.1 0.6 GO:0044530 supraspliceosomal complex(GO:0044530)
0.1 1.3 GO:0000177 cytoplasmic exosome (RNase complex)(GO:0000177)
0.0 0.8 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 0.5 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 0.5 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 0.2 GO:0044305 calyx of Held(GO:0044305)
0.0 0.3 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.0 0.2 GO:0000801 central element(GO:0000801)
0.0 1.3 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 0.1 GO:0098843 postsynaptic endocytic zone(GO:0098843)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.4 GO:0008112 nicotinamide N-methyltransferase activity(GO:0008112) pyridine N-methyltransferase activity(GO:0030760)
0.1 0.5 GO:0043515 kinetochore binding(GO:0043515)
0.1 0.3 GO:0004822 isoleucine-tRNA ligase activity(GO:0004822)
0.1 0.8 GO:0086007 voltage-gated calcium channel activity involved in cardiac muscle cell action potential(GO:0086007)
0.1 0.5 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.1 0.2 GO:0044549 GTP cyclohydrolase binding(GO:0044549)
0.1 1.6 GO:0002162 dystroglycan binding(GO:0002162)
0.0 1.3 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656)
0.0 0.8 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.0 0.8 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 0.4 GO:0051378 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.0 0.3 GO:1990829 C-rich single-stranded DNA binding(GO:1990829)
0.0 1.5 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 1.3 GO:0000175 3'-5'-exoribonuclease activity(GO:0000175)
0.0 0.2 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.0 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.5 REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.0 0.4 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.0 1.0 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.3 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 1.4 REACTOME PHASE II CONJUGATION Genes involved in Phase II conjugation