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SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for ISL1

Z-value: 0.69

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Transcription factors associated with ISL1

Gene Symbol Gene ID Gene Info
ISL1
ENSG00000016082.10 ISL LIM homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ISL1hg19_v2_chr5_+_50678921_50678921-0.272.5e-01Click!

Activity profile of ISL1 motif

Sorted Z-values of ISL1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr7_-_107880508 1.31 ENST00000425651.2
NRCAM
neuronal cell adhesion molecule
chr20_+_60174827 1.20 ENST00000543233.1
CDH4
cadherin 4, type 1, R-cadherin (retinal)
chr2_-_175711133 1.07 ENST00000409597.1
ENST00000413882.1
CHN1
chimerin 1
chr7_-_81635106 1.04 ENST00000443883.1
CACNA2D1
calcium channel, voltage-dependent, alpha 2/delta subunit 1
chrX_-_30327495 0.94 ENST00000453287.1
NR0B1
nuclear receptor subfamily 0, group B, member 1
chr5_+_32710736 0.94 ENST00000415685.2
NPR3
natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)
chr11_-_115127611 0.82 ENST00000545094.1
CADM1
cell adhesion molecule 1
chr5_+_102455853 0.78 ENST00000515845.1
ENST00000321521.9
ENST00000507921.1
PPIP5K2
diphosphoinositol pentakisphosphate kinase 2
chr6_-_130031358 0.78 ENST00000368149.2
ARHGAP18
Rho GTPase activating protein 18
chr6_-_108278456 0.77 ENST00000429168.1
SEC63
SEC63 homolog (S. cerevisiae)
chr5_-_94417562 0.76 ENST00000505465.1
MCTP1
multiple C2 domains, transmembrane 1
chr11_+_123430948 0.75 ENST00000529432.1
ENST00000534764.1
GRAMD1B
GRAM domain containing 1B
chrX_+_10031499 0.70 ENST00000454666.1
WWC3
WWC family member 3
chrX_-_119693745 0.69 ENST00000371323.2
CUL4B
cullin 4B
chr3_+_142342228 0.68 ENST00000337777.3
PLS1
plastin 1
chr11_+_7618413 0.63 ENST00000528883.1
PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr12_+_50144381 0.62 ENST00000552370.1
TMBIM6
transmembrane BAX inhibitor motif containing 6
chr5_+_32711419 0.60 ENST00000265074.8
NPR3
natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)
chr6_-_131211534 0.56 ENST00000456097.2
EPB41L2
erythrocyte membrane protein band 4.1-like 2
chr5_-_94417339 0.56 ENST00000429576.2
ENST00000508509.1
ENST00000510732.1
MCTP1
multiple C2 domains, transmembrane 1
chr10_+_17270214 0.54 ENST00000544301.1
VIM
vimentin
chr10_-_95242044 0.53 ENST00000371501.4
ENST00000371502.4
ENST00000371489.1
MYOF
myoferlin
chr9_+_2029019 0.53 ENST00000382194.1
SMARCA2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr8_+_26371763 0.53 ENST00000521913.1
DPYSL2
dihydropyrimidinase-like 2
chr4_+_169418195 0.53 ENST00000261509.6
ENST00000335742.7
PALLD
palladin, cytoskeletal associated protein
chr4_+_169418255 0.52 ENST00000505667.1
ENST00000511948.1
PALLD
palladin, cytoskeletal associated protein
chr2_+_183582774 0.52 ENST00000537515.1
DNAJC10
DnaJ (Hsp40) homolog, subfamily C, member 10
chr7_+_105172612 0.51 ENST00000493041.1
RINT1
RAD50 interactor 1
chr8_-_131399110 0.50 ENST00000521426.1
ASAP1
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
chr3_-_33686925 0.50 ENST00000485378.2
ENST00000313350.6
ENST00000487200.1
CLASP2
cytoplasmic linker associated protein 2
chr6_-_111136299 0.50 ENST00000457688.1
CDK19
cyclin-dependent kinase 19
chr10_-_115613828 0.50 ENST00000361384.2
DCLRE1A
DNA cross-link repair 1A
chr15_+_59903975 0.50 ENST00000560585.1
ENST00000396065.1
GCNT3
glucosaminyl (N-acetyl) transferase 3, mucin type
chr1_-_100598444 0.49 ENST00000535161.1
ENST00000287482.5
SASS6
spindle assembly 6 homolog (C. elegans)
chr1_-_108231101 0.49 ENST00000544443.1
ENST00000415432.2
VAV3
vav 3 guanine nucleotide exchange factor
chr15_-_72767490 0.48 ENST00000565181.1
RP11-1007O24.3
RP11-1007O24.3
chr1_+_200011711 0.48 ENST00000544748.1
NR5A2
nuclear receptor subfamily 5, group A, member 2
chr1_-_232651312 0.48 ENST00000262861.4
SIPA1L2
signal-induced proliferation-associated 1 like 2
chr17_-_47045949 0.47 ENST00000357424.2
GIP
gastric inhibitory polypeptide
chr20_-_25320367 0.47 ENST00000450393.1
ENST00000491682.1
ABHD12
abhydrolase domain containing 12
chrX_+_135252050 0.46 ENST00000449474.1
ENST00000345434.3
FHL1
four and a half LIM domains 1
chr8_+_53850991 0.46 ENST00000331251.3
NPBWR1
neuropeptides B/W receptor 1
chr12_-_102591604 0.46 ENST00000329406.4
PMCH
pro-melanin-concentrating hormone
chr5_+_138210919 0.45 ENST00000522013.1
ENST00000520260.1
ENST00000523298.1
ENST00000520865.1
ENST00000519634.1
ENST00000517533.1
ENST00000523685.1
ENST00000519768.1
ENST00000517656.1
ENST00000521683.1
ENST00000521640.1
ENST00000519116.1
CTNNA1
catenin (cadherin-associated protein), alpha 1, 102kDa
chr12_+_79439461 0.45 ENST00000552624.1
SYT1
synaptotagmin I
chr5_-_94417186 0.44 ENST00000312216.8
ENST00000512425.1
MCTP1
multiple C2 domains, transmembrane 1
chr19_-_42759266 0.44 ENST00000594664.1
AC006486.9
Uncharacterized protein
chr8_-_101321584 0.43 ENST00000523167.1
RNF19A
ring finger protein 19A, RBR E3 ubiquitin protein ligase
chr10_-_36813162 0.43 ENST00000440465.1
NAMPTL
nicotinamide phosphoribosyltransferase-like
chr17_-_57229155 0.43 ENST00000584089.1
SKA2
spindle and kinetochore associated complex subunit 2
chr12_-_52761262 0.43 ENST00000257901.3
KRT85
keratin 85
chr18_-_2982869 0.41 ENST00000584915.1
LPIN2
lipin 2
chr3_-_138312971 0.41 ENST00000485115.1
ENST00000484888.1
ENST00000468900.1
ENST00000542237.1
ENST00000481834.1
CEP70
centrosomal protein 70kDa
chr1_-_197169672 0.41 ENST00000367405.4
ZBTB41
zinc finger and BTB domain containing 41
chr17_-_15501932 0.40 ENST00000583965.1
CDRT1
CMT1A duplicated region transcript 1
chr10_-_95241951 0.40 ENST00000358334.5
ENST00000359263.4
ENST00000371488.3
MYOF
myoferlin
chr5_+_32788945 0.40 ENST00000326958.1
AC026703.1
AC026703.1
chr8_-_19540266 0.38 ENST00000311540.4
CSGALNACT1
chondroitin sulfate N-acetylgalactosaminyltransferase 1
chr11_-_107729504 0.38 ENST00000265836.7
SLC35F2
solute carrier family 35, member F2
chr16_+_20775358 0.37 ENST00000440284.2
ACSM3
acyl-CoA synthetase medium-chain family member 3
chrX_+_135251835 0.37 ENST00000456445.1
FHL1
four and a half LIM domains 1
chr11_-_107729287 0.37 ENST00000375682.4
SLC35F2
solute carrier family 35, member F2
chr10_-_27529486 0.36 ENST00000375888.1
ACBD5
acyl-CoA binding domain containing 5
chr21_-_16374688 0.36 ENST00000411932.1
NRIP1
nuclear receptor interacting protein 1
chr6_+_108977520 0.36 ENST00000540898.1
FOXO3
forkhead box O3
chr3_-_27498235 0.35 ENST00000295736.5
ENST00000428386.1
ENST00000428179.1
SLC4A7
solute carrier family 4, sodium bicarbonate cotransporter, member 7
chr3_-_135913298 0.35 ENST00000434835.2
MSL2
male-specific lethal 2 homolog (Drosophila)
chr5_+_102200948 0.35 ENST00000511477.1
ENST00000506006.1
ENST00000509832.1
PAM
peptidylglycine alpha-amidating monooxygenase
chr5_+_142286887 0.35 ENST00000451259.1
ARHGAP26
Rho GTPase activating protein 26
chr8_-_19540086 0.35 ENST00000332246.6
CSGALNACT1
chondroitin sulfate N-acetylgalactosaminyltransferase 1
chr4_+_4861385 0.34 ENST00000382723.4
MSX1
msh homeobox 1
chr2_+_172309634 0.34 ENST00000339506.3
DCAF17
DDB1 and CUL4 associated factor 17
chr15_+_65822756 0.34 ENST00000562901.1
ENST00000261875.5
ENST00000442729.2
ENST00000565299.1
ENST00000568793.1
PTPLAD1
protein tyrosine phosphatase-like A domain containing 1
chr8_+_21911054 0.34 ENST00000519850.1
ENST00000381470.3
DMTN
dematin actin binding protein
chr9_-_92112953 0.33 ENST00000339861.4
ENST00000422704.2
ENST00000455551.2
SEMA4D
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
chr6_+_167704798 0.33 ENST00000230256.3
UNC93A
unc-93 homolog A (C. elegans)
chr8_+_42873548 0.33 ENST00000533338.1
ENST00000534420.1
HOOK3
RP11-598P20.5
hook microtubule-tethering protein 3
Uncharacterized protein
chr2_-_208030886 0.32 ENST00000426163.1
KLF7
Kruppel-like factor 7 (ubiquitous)
chr17_+_63096903 0.32 ENST00000582940.1
RP11-160O5.1
RP11-160O5.1
chr6_-_111804905 0.31 ENST00000358835.3
ENST00000435970.1
REV3L
REV3-like, polymerase (DNA directed), zeta, catalytic subunit
chr22_-_43355858 0.31 ENST00000402229.1
ENST00000407585.1
ENST00000453079.1
PACSIN2
protein kinase C and casein kinase substrate in neurons 2
chr2_-_68547061 0.30 ENST00000263655.3
CNRIP1
cannabinoid receptor interacting protein 1
chr5_-_94417314 0.30 ENST00000505208.1
MCTP1
multiple C2 domains, transmembrane 1
chr9_-_86323118 0.30 ENST00000376395.4
UBQLN1
ubiquilin 1
chr6_-_24720226 0.30 ENST00000378102.3
C6orf62
chromosome 6 open reading frame 62
chr7_-_14026063 0.30 ENST00000443608.1
ENST00000438956.1
ETV1
ets variant 1
chr9_-_134585221 0.29 ENST00000372190.3
ENST00000427994.1
RAPGEF1
Rap guanine nucleotide exchange factor (GEF) 1
chr12_+_79357815 0.29 ENST00000547046.1
SYT1
synaptotagmin I
chr2_-_175711978 0.29 ENST00000409089.2
CHN1
chimerin 1
chr12_-_96793142 0.29 ENST00000552262.1
ENST00000551816.1
ENST00000552496.1
CDK17
cyclin-dependent kinase 17
chr16_+_20775024 0.29 ENST00000289416.5
ACSM3
acyl-CoA synthetase medium-chain family member 3
chr6_+_167704838 0.28 ENST00000366829.2
UNC93A
unc-93 homolog A (C. elegans)
chr5_+_34757309 0.28 ENST00000397449.1
RAI14
retinoic acid induced 14
chr5_-_102455801 0.28 ENST00000508629.1
ENST00000399004.2
GIN1
gypsy retrotransposon integrase 1
chr6_+_35996859 0.28 ENST00000472333.1
MAPK14
mitogen-activated protein kinase 14
chr19_-_42806842 0.27 ENST00000596265.1
PAFAH1B3
platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
chr13_-_99667960 0.27 ENST00000448493.2
DOCK9
dedicator of cytokinesis 9
chr15_+_59279851 0.27 ENST00000348370.4
ENST00000434298.1
ENST00000559160.1
RNF111
ring finger protein 111
chr17_-_40729681 0.26 ENST00000590760.1
ENST00000587209.1
ENST00000393795.3
ENST00000253789.5
PSMC3IP
PSMC3 interacting protein
chr7_-_150675372 0.26 ENST00000262186.5
KCNH2
potassium voltage-gated channel, subfamily H (eag-related), member 2
chr10_-_89577910 0.26 ENST00000308448.7
ENST00000541004.1
ATAD1
ATPase family, AAA domain containing 1
chrX_+_135251783 0.26 ENST00000394153.2
FHL1
four and a half LIM domains 1
chr8_+_35092959 0.25 ENST00000404895.2
UNC5D
unc-5 homolog D (C. elegans)
chr18_-_19283649 0.25 ENST00000584464.1
ENST00000578270.1
ABHD3
abhydrolase domain containing 3
chr17_+_66521936 0.25 ENST00000592800.1
PRKAR1A
protein kinase, cAMP-dependent, regulatory, type I, alpha
chr13_+_78315466 0.24 ENST00000314070.5
ENST00000462234.1
SLAIN1
SLAIN motif family, member 1
chrX_+_72783026 0.24 ENST00000373504.6
ENST00000373502.5
CHIC1
cysteine-rich hydrophobic domain 1
chr8_+_19536083 0.24 ENST00000519803.1
RP11-1105O14.1
RP11-1105O14.1
chr1_-_8000872 0.24 ENST00000377507.3
TNFRSF9
tumor necrosis factor receptor superfamily, member 9
chrX_+_114874727 0.24 ENST00000543070.1
PLS3
plastin 3
chr5_-_79950775 0.24 ENST00000439211.2
DHFR
dihydrofolate reductase
chr10_-_17659357 0.24 ENST00000326961.6
ENST00000361271.3
PTPLA
protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A
chr20_+_19870167 0.23 ENST00000440354.2
RIN2
Ras and Rab interactor 2
chr6_-_111136513 0.23 ENST00000368911.3
CDK19
cyclin-dependent kinase 19
chr3_-_33686743 0.23 ENST00000333778.6
ENST00000539981.1
CLASP2
cytoplasmic linker associated protein 2
chr6_+_144904334 0.22 ENST00000367526.4
UTRN
utrophin
chr5_+_134181755 0.22 ENST00000504727.1
ENST00000435259.2
ENST00000508791.1
C5orf24
chromosome 5 open reading frame 24
chr12_+_54410664 0.22 ENST00000303406.4
HOXC4
homeobox C4
chr17_-_64225508 0.22 ENST00000205948.6
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr4_-_128887069 0.22 ENST00000541133.1
ENST00000296468.3
ENST00000513559.1
MFSD8
major facilitator superfamily domain containing 8
chr9_-_96108696 0.22 ENST00000375419.1
C9orf129
chromosome 9 open reading frame 129
chr3_+_158787041 0.21 ENST00000471575.1
ENST00000476809.1
ENST00000485419.1
IQCJ-SCHIP1
IQCJ-SCHIP1 readthrough
chr14_+_62164340 0.21 ENST00000557538.1
ENST00000539097.1
HIF1A
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
chr13_+_108870714 0.21 ENST00000375898.3
ABHD13
abhydrolase domain containing 13
chr9_-_113761720 0.21 ENST00000541779.1
ENST00000374430.2
LPAR1
lysophosphatidic acid receptor 1
chr9_+_128510454 0.21 ENST00000491787.3
ENST00000447726.2
PBX3
pre-B-cell leukemia homeobox 3
chr11_-_66496430 0.21 ENST00000533211.1
SPTBN2
spectrin, beta, non-erythrocytic 2
chr4_+_113970772 0.20 ENST00000504454.1
ENST00000394537.3
ENST00000357077.4
ENST00000264366.6
ANK2
ankyrin 2, neuronal
chr12_-_121454148 0.20 ENST00000535367.1
ENST00000538296.1
ENST00000445832.3
ENST00000536407.2
ENST00000366211.2
ENST00000539736.1
ENST00000288757.3
ENST00000537817.1
C12orf43
chromosome 12 open reading frame 43
chr5_+_140248518 0.20 ENST00000398640.2
PCDHA11
protocadherin alpha 11
chr10_-_116444371 0.20 ENST00000533213.2
ENST00000369252.4
ABLIM1
actin binding LIM protein 1
chr5_+_135468516 0.19 ENST00000507118.1
ENST00000511116.1
ENST00000545279.1
ENST00000545620.1
SMAD5
SMAD family member 5
chr8_-_101571964 0.19 ENST00000520552.1
ENST00000521345.1
ENST00000523000.1
ENST00000335659.3
ENST00000358990.3
ENST00000519597.1
ANKRD46
ankyrin repeat domain 46
chr14_+_61449076 0.19 ENST00000526105.1
SLC38A6
solute carrier family 38, member 6
chr15_-_55541227 0.19 ENST00000566877.1
RAB27A
RAB27A, member RAS oncogene family
chr1_+_15986364 0.18 ENST00000345034.1
RSC1A1
regulatory solute carrier protein, family 1, member 1
chr16_-_3350614 0.18 ENST00000268674.2
TIGD7
tigger transposable element derived 7
chr1_-_119682812 0.18 ENST00000537870.1
WARS2
tryptophanyl tRNA synthetase 2, mitochondrial
chr12_+_14572070 0.18 ENST00000545769.1
ENST00000428217.2
ENST00000396279.2
ENST00000542514.1
ENST00000536279.1
ATF7IP
activating transcription factor 7 interacting protein
chr17_-_2615031 0.17 ENST00000576885.1
ENST00000574426.2
CLUH
clustered mitochondria (cluA/CLU1) homolog
chr13_+_78315295 0.17 ENST00000351546.3
SLAIN1
SLAIN motif family, member 1
chr13_+_28527647 0.17 ENST00000567234.1
LINC00543
long intergenic non-protein coding RNA 543
chrX_-_15683147 0.16 ENST00000380342.3
TMEM27
transmembrane protein 27
chr2_-_224467002 0.16 ENST00000421386.1
ENST00000433889.1
SCG2
secretogranin II
chr2_-_175202151 0.16 ENST00000595354.1
AC018470.1
Uncharacterized protein FLJ46347
chr6_+_149539053 0.16 ENST00000451095.1
RP1-111D6.3
RP1-111D6.3
chr7_+_90012986 0.16 ENST00000416322.1
CLDN12
claudin 12
chr3_-_149095652 0.15 ENST00000305366.3
TM4SF1
transmembrane 4 L six family member 1
chr4_+_139694701 0.15 ENST00000502606.1
RP11-98O2.1
RP11-98O2.1
chr7_-_35734176 0.15 ENST00000413517.1
ENST00000438224.1
HERPUD2
HERPUD family member 2
chr17_-_39341594 0.15 ENST00000398472.1
KRTAP4-1
keratin associated protein 4-1
chr12_+_9066472 0.15 ENST00000538657.1
PHC1
polyhomeotic homolog 1 (Drosophila)
chr2_-_208030295 0.15 ENST00000458272.1
KLF7
Kruppel-like factor 7 (ubiquitous)
chr17_+_26698677 0.15 ENST00000457710.3
SARM1
sterile alpha and TIR motif containing 1
chr2_-_55920952 0.15 ENST00000447944.2
PNPT1
polyribonucleotide nucleotidyltransferase 1
chr3_+_35721106 0.14 ENST00000474696.1
ENST00000412048.1
ENST00000396482.2
ENST00000432682.1
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr2_-_208030647 0.14 ENST00000309446.6
KLF7
Kruppel-like factor 7 (ubiquitous)
chr13_+_78315348 0.14 ENST00000441784.1
SLAIN1
SLAIN motif family, member 1
chr2_-_74735707 0.14 ENST00000233630.6
PCGF1
polycomb group ring finger 1
chr10_+_51572408 0.13 ENST00000374082.1
NCOA4
nuclear receptor coactivator 4
chr1_+_221054411 0.13 ENST00000427693.1
HLX
H2.0-like homeobox
chr3_+_157154578 0.13 ENST00000295927.3
PTX3
pentraxin 3, long
chr9_+_131084846 0.13 ENST00000608951.1
COQ4
coenzyme Q4
chr7_+_13141010 0.12 ENST00000443947.1
AC011288.2
AC011288.2
chr10_+_114710425 0.12 ENST00000352065.5
ENST00000369395.1
TCF7L2
transcription factor 7-like 2 (T-cell specific, HMG-box)
chr14_+_20811766 0.12 ENST00000250416.5
ENST00000527915.1
PARP2
poly (ADP-ribose) polymerase 2
chr1_-_93257951 0.11 ENST00000543509.1
ENST00000370331.1
ENST00000540033.1
EVI5
ecotropic viral integration site 5
chr12_+_54402790 0.11 ENST00000040584.4
HOXC8
homeobox C8
chr1_+_150980889 0.11 ENST00000450884.1
ENST00000271620.3
ENST00000271619.8
ENST00000368937.1
ENST00000431193.1
ENST00000368936.1
PRUNE
prune exopolyphosphatase
chr6_+_15401075 0.11 ENST00000541660.1
JARID2
jumonji, AT rich interactive domain 2
chr13_+_111893533 0.11 ENST00000478679.1
ARHGEF7
Rho guanine nucleotide exchange factor (GEF) 7
chr17_-_41132010 0.10 ENST00000409103.1
ENST00000360221.4
PTGES3L-AARSD1
PTGES3L-AARSD1 readthrough
chrX_-_102941596 0.09 ENST00000441076.2
ENST00000422355.1
ENST00000442614.1
ENST00000422154.2
ENST00000451301.1
MORF4L2
mortality factor 4 like 2
chr14_-_77495007 0.09 ENST00000238647.3
IRF2BPL
interferon regulatory factor 2 binding protein-like
chr2_+_149402009 0.09 ENST00000457184.1
EPC2
enhancer of polycomb homolog 2 (Drosophila)
chr7_+_16793160 0.09 ENST00000262067.4
TSPAN13
tetraspanin 13
chrX_-_102983417 0.08 ENST00000372617.4
GLRA4
glycine receptor, alpha 4
chr3_-_49066811 0.08 ENST00000442157.1
ENST00000326739.4
IMPDH2
IMP (inosine 5'-monophosphate) dehydrogenase 2
chr2_-_224467093 0.08 ENST00000305409.2
SCG2
secretogranin II
chr1_+_12776118 0.08 ENST00000332530.3
ENST00000359318.5
AADACL3
arylacetamide deacetylase-like 3
chr2_+_28618532 0.08 ENST00000545753.1
FOSL2
FOS-like antigen 2
chr11_-_40315640 0.08 ENST00000278198.2
LRRC4C
leucine rich repeat containing 4C
chr8_-_79717750 0.08 ENST00000263851.4
ENST00000379113.2
IL7
interleukin 7
chr5_-_142782862 0.07 ENST00000415690.2
NR3C1
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr1_-_169555709 0.07 ENST00000546081.1
F5
coagulation factor V (proaccelerin, labile factor)
chr3_-_100712352 0.07 ENST00000471714.1
ENST00000284322.5
ABI3BP
ABI family, member 3 (NESH) binding protein
chr1_+_161736072 0.07 ENST00000367942.3
ATF6
activating transcription factor 6
chr1_+_100598691 0.07 ENST00000370143.1
ENST00000370141.2
TRMT13
tRNA methyltransferase 13 homolog (S. cerevisiae)
chr18_-_21977748 0.07 ENST00000399441.4
ENST00000319481.3
OSBPL1A
oxysterol binding protein-like 1A
chr11_-_7904464 0.07 ENST00000502624.2
ENST00000527565.1
RP11-35J10.5
RP11-35J10.5
chr1_+_109265033 0.07 ENST00000445274.1
FNDC7
fibronectin type III domain containing 7
chr1_+_100598742 0.06 ENST00000370139.1
TRMT13
tRNA methyltransferase 13 homolog (S. cerevisiae)
chr16_+_47496023 0.06 ENST00000567200.1
PHKB
phosphorylase kinase, beta
chr2_+_172543919 0.06 ENST00000452242.1
ENST00000340296.4
DYNC1I2
dynein, cytoplasmic 1, intermediate chain 2
chr1_+_217804661 0.06 ENST00000366933.4
SPATA17
spermatogenesis associated 17
chr2_+_128377550 0.06 ENST00000437387.1
ENST00000409090.1
MYO7B
myosin VIIB
chr22_-_32651326 0.06 ENST00000266086.4
SLC5A4
solute carrier family 5 (glucose activated ion channel), member 4
chr9_+_134165195 0.06 ENST00000372261.1
PPAPDC3
phosphatidic acid phosphatase type 2 domain containing 3
chr5_-_56778635 0.06 ENST00000423391.1
ACTBL2
actin, beta-like 2
chr12_+_116955659 0.06 ENST00000552992.1
RP11-148B3.1
RP11-148B3.1

Network of associatons between targets according to the STRING database.

First level regulatory network of ISL1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0031204 posttranslational protein targeting to membrane, translocation(GO:0031204)
0.1 0.8 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.1 1.0 GO:0086048 membrane depolarization during bundle of His cell action potential(GO:0086048)
0.1 0.7 GO:0098746 fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746)
0.1 0.5 GO:0002426 immunoglobulin production in mucosal tissue(GO:0002426)
0.1 0.4 GO:0001543 ovarian follicle rupture(GO:0001543)
0.1 0.4 GO:0001544 initiation of primordial ovarian follicle growth(GO:0001544)
0.1 0.5 GO:0046462 monoacylglycerol metabolic process(GO:0046462) monoacylglycerol catabolic process(GO:0052651)
0.1 0.3 GO:0090427 activation of meiosis(GO:0090427)
0.1 0.3 GO:1901340 negative regulation of store-operated calcium channel activity(GO:1901340)
0.1 0.7 GO:1902896 terminal web assembly(GO:1902896)
0.1 0.7 GO:0050653 chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0050653)
0.1 0.5 GO:2001045 negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.1 1.5 GO:0002158 osteoclast proliferation(GO:0002158)
0.1 0.6 GO:1904721 negative regulation of mRNA cleavage(GO:0031438) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721)
0.1 0.3 GO:1902303 regulation of heart rate by hormone(GO:0003064) negative regulation of potassium ion export(GO:1902303)
0.1 0.5 GO:0072425 signal transduction involved in G2 DNA damage checkpoint(GO:0072425) signal transduction involved in mitotic G2 DNA damage checkpoint(GO:0072434)
0.1 0.5 GO:1903527 positive regulation of membrane tubulation(GO:1903527)
0.1 1.3 GO:0098870 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.1 0.9 GO:0001778 plasma membrane repair(GO:0001778)
0.1 0.2 GO:0007387 anterior compartment pattern formation(GO:0007387) posterior compartment specification(GO:0007388)
0.1 0.5 GO:0061113 pancreas morphogenesis(GO:0061113)
0.1 0.5 GO:0070092 regulation of glucagon secretion(GO:0070092)
0.1 0.2 GO:0046452 dihydrofolate metabolic process(GO:0046452)
0.1 0.4 GO:0018032 protein amidation(GO:0018032)
0.1 0.3 GO:0014835 myoblast differentiation involved in skeletal muscle regeneration(GO:0014835)
0.1 0.3 GO:0010693 negative regulation of alkaline phosphatase activity(GO:0010693) semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis(GO:1900220)
0.1 0.2 GO:0001922 B-1 B cell homeostasis(GO:0001922)
0.1 0.7 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.0 0.1 GO:2000627 rRNA import into mitochondrion(GO:0035928) regulation of miRNA catabolic process(GO:2000625) positive regulation of miRNA catabolic process(GO:2000627)
0.0 0.2 GO:2001180 negative regulation of interleukin-10 secretion(GO:2001180) negative regulation of interleukin-12 secretion(GO:2001183)
0.0 0.9 GO:0033327 Leydig cell differentiation(GO:0033327)
0.0 0.7 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091)
0.0 0.5 GO:0060020 Bergmann glial cell differentiation(GO:0060020)
0.0 1.2 GO:0003334 keratinocyte development(GO:0003334)
0.0 0.2 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.0 0.3 GO:0022027 interkinetic nuclear migration(GO:0022027)
0.0 0.2 GO:0036371 protein localization to T-tubule(GO:0036371)
0.0 0.4 GO:0030242 pexophagy(GO:0030242)
0.0 0.5 GO:0038003 opioid receptor signaling pathway(GO:0038003)
0.0 0.3 GO:1901731 positive regulation of platelet aggregation(GO:1901731)
0.0 0.8 GO:0006020 inositol metabolic process(GO:0006020)
0.0 0.2 GO:0001880 Mullerian duct regression(GO:0001880)
0.0 0.7 GO:0070914 UV-damage excision repair(GO:0070914)
0.0 0.5 GO:0031848 protection from non-homologous end joining at telomere(GO:0031848)
0.0 0.2 GO:0006436 tryptophanyl-tRNA aminoacylation(GO:0006436)
0.0 0.3 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0 0.1 GO:0018312 peptidyl-serine ADP-ribosylation(GO:0018312)
0.0 0.3 GO:0070836 caveola assembly(GO:0070836)
0.0 0.2 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
0.0 1.4 GO:0008045 motor neuron axon guidance(GO:0008045)
0.0 0.5 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.0 0.6 GO:1904778 regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778)
0.0 0.1 GO:0044793 negative regulation by host of viral process(GO:0044793) negative regulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052199)
0.0 0.3 GO:0015074 DNA integration(GO:0015074)
0.0 0.3 GO:0021859 pyramidal neuron differentiation(GO:0021859)
0.0 0.2 GO:0034392 negative regulation of smooth muscle cell apoptotic process(GO:0034392)
0.0 1.2 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 0.1 GO:0045629 negative regulation of T-helper 2 cell differentiation(GO:0045629)
0.0 0.2 GO:0048245 eosinophil chemotaxis(GO:0048245)
0.0 0.0 GO:1904204 regulation of skeletal muscle hypertrophy(GO:1904204)
0.0 1.1 GO:0043268 positive regulation of potassium ion transport(GO:0043268)
0.0 0.3 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.0 0.4 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.0 0.1 GO:0034128 negative regulation of MyD88-independent toll-like receptor signaling pathway(GO:0034128)
0.0 0.3 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.0 0.2 GO:0014877 response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.0 0.1 GO:0032571 response to vitamin K(GO:0032571)
0.0 0.1 GO:0006990 positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response(GO:0006990)
0.0 0.1 GO:0006177 GMP biosynthetic process(GO:0006177)
0.0 0.2 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.0 0.2 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.0 0.2 GO:0038180 nerve growth factor signaling pathway(GO:0038180)
0.0 0.1 GO:1902730 regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) myoblast fate commitment(GO:0048625) positive regulation of proteoglycan biosynthetic process(GO:1902730)
0.0 0.4 GO:0060117 auditory receptor cell development(GO:0060117)
0.0 0.3 GO:0007638 mechanosensory behavior(GO:0007638)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0070939 Dsl1p complex(GO:0070939)
0.1 0.7 GO:1990357 terminal web(GO:1990357)
0.1 1.1 GO:0042788 polysomal ribosome(GO:0042788)
0.1 0.7 GO:0060201 clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
0.1 0.5 GO:0098536 deuterosome(GO:0098536)
0.1 0.7 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.1 0.3 GO:1902937 inward rectifier potassium channel complex(GO:1902937)
0.1 1.0 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.1 0.3 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.0 0.7 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 0.8 GO:0008091 spectrin(GO:0008091)
0.0 0.9 GO:0043194 axon initial segment(GO:0043194)
0.0 0.4 GO:0072487 MSL complex(GO:0072487)
0.0 0.5 GO:0016600 flotillin complex(GO:0016600)
0.0 0.4 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 0.1 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 0.5 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 0.1 GO:0005902 microvillus(GO:0005902) actin-based cell projection(GO:0098858)
0.0 0.3 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 1.6 GO:0002102 podosome(GO:0002102)
0.0 0.5 GO:0071564 npBAF complex(GO:0071564)
0.0 0.7 GO:0016592 mediator complex(GO:0016592)
0.0 0.2 GO:0031045 dense core granule(GO:0031045)
0.0 0.2 GO:0031089 platelet dense granule lumen(GO:0031089)
0.0 0.3 GO:0000242 pericentriolar material(GO:0000242)
0.0 0.2 GO:0070938 contractile ring(GO:0070938)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0086057 voltage-gated calcium channel activity involved in bundle of His cell action potential(GO:0086057)
0.2 1.5 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.2 0.5 GO:0047225 acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0047225)
0.1 0.5 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.1 0.7 GO:0008955 peptidoglycan glycosyltransferase activity(GO:0008955)
0.1 0.8 GO:0033857 diphosphoinositol-pentakisphosphate kinase activity(GO:0033857)
0.1 0.6 GO:0060698 endoribonuclease inhibitor activity(GO:0060698)
0.1 0.5 GO:1990254 keratin filament binding(GO:1990254)
0.1 0.4 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.1 0.3 GO:0032184 SUMO polymer binding(GO:0032184)
0.1 0.6 GO:0030348 syntaxin-3 binding(GO:0030348)
0.1 0.7 GO:0004321 fatty-acyl-CoA synthase activity(GO:0004321)
0.1 0.4 GO:0004598 peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598)
0.1 0.3 GO:0052740 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740)
0.0 1.3 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.0 0.5 GO:0004985 opioid receptor activity(GO:0004985)
0.0 0.3 GO:0047179 platelet-activating factor acetyltransferase activity(GO:0047179)
0.0 0.2 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.0 0.6 GO:0042731 PH domain binding(GO:0042731)
0.0 0.2 GO:0051870 methotrexate binding(GO:0051870)
0.0 0.5 GO:0035312 5'-3' exodeoxyribonuclease activity(GO:0035312)
0.0 1.0 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 0.3 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.0 0.2 GO:0004830 tryptophan-tRNA ligase activity(GO:0004830)
0.0 0.1 GO:1990404 protein ADP-ribosylase activity(GO:1990404)
0.0 0.5 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.7 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.7 GO:0017166 vinculin binding(GO:0017166)
0.0 0.9 GO:0000217 DNA secondary structure binding(GO:0000217)
0.0 1.4 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.3 GO:0051525 NFAT protein binding(GO:0051525)
0.0 0.1 GO:0034046 poly(G) binding(GO:0034046)
0.0 0.5 GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671)
0.0 0.2 GO:0070915 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.0 0.3 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0 1.8 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 0.1 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.0 0.2 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0 0.3 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.1 GO:0001849 complement component C1q binding(GO:0001849) virion binding(GO:0046790)
0.0 0.1 GO:0016934 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.0 0.4 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.3 GO:0070300 phosphatidic acid binding(GO:0070300)
0.0 0.4 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.0 0.0 GO:0008431 vitamin E binding(GO:0008431)
0.0 0.4 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.5 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.3 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.0 2.0 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.0 0.5 PID ARF 3PATHWAY Arf1 pathway
0.0 0.2 PID VEGFR1 PATHWAY VEGFR1 specific signals
0.0 0.6 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.0 0.7 PID NECTIN PATHWAY Nectin adhesion pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.5 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.7 REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.0 1.0 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.5 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 0.7 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.4 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.0 0.5 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 1.4 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.3 REACTOME ARMS MEDIATED ACTIVATION Genes involved in ARMS-mediated activation
0.0 3.0 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.3 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse