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SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for ISL2

Z-value: 0.74

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Transcription factors associated with ISL2

Gene Symbol Gene ID Gene Info
ISL2
ENSG00000159556.5 ISL LIM homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ISL2hg19_v2_chr15_+_76629064_766290730.784.4e-05Click!

Activity profile of ISL2 motif

Sorted Z-values of ISL2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr17_-_64225508 2.31 ENST00000205948.6
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr7_-_107883678 2.20 ENST00000417701.1
NRCAM
neuronal cell adhesion molecule
chr11_-_28129656 1.75 ENST00000263181.6
KIF18A
kinesin family member 18A
chr1_-_238108575 1.50 ENST00000604646.1
MTRNR2L11
MT-RNR2-like 11 (pseudogene)
chr6_-_24358264 1.45 ENST00000378454.3
DCDC2
doublecortin domain containing 2
chr1_+_66820058 1.43 ENST00000480109.2
PDE4B
phosphodiesterase 4B, cAMP-specific
chr10_-_5046042 1.36 ENST00000421196.3
ENST00000455190.1
AKR1C2
aldo-keto reductase family 1, member C2
chr1_+_149871171 1.36 ENST00000369150.1
BOLA1
bolA family member 1
chr3_+_172468505 1.33 ENST00000427830.1
ENST00000417960.1
ENST00000428567.1
ENST00000366090.2
ENST00000426894.1
ECT2
epithelial cell transforming sequence 2 oncogene
chr15_+_90735145 1.27 ENST00000559792.1
SEMA4B
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B
chr8_-_124741451 1.24 ENST00000520519.1
ANXA13
annexin A13
chr1_+_149871135 1.23 ENST00000369152.5
BOLA1
bolA family member 1
chr3_-_20227619 1.20 ENST00000425061.1
ENST00000443724.1
ENST00000421451.1
ENST00000452020.1
ENST00000417364.1
ENST00000306698.2
ENST00000419233.2
ENST00000263753.4
ENST00000383774.1
ENST00000437051.1
ENST00000412868.1
ENST00000429446.3
ENST00000442720.1
SGOL1
shugoshin-like 1 (S. pombe)
chr3_+_172468472 1.15 ENST00000232458.5
ENST00000392692.3
ECT2
epithelial cell transforming sequence 2 oncogene
chr3_+_159943362 1.11 ENST00000326474.3
C3orf80
chromosome 3 open reading frame 80
chr17_-_48785216 1.10 ENST00000285243.6
ANKRD40
ankyrin repeat domain 40
chr10_+_35484793 1.07 ENST00000488741.1
ENST00000474931.1
ENST00000468236.1
ENST00000344351.5
ENST00000490511.1
CREM
cAMP responsive element modulator
chr7_-_16844611 1.06 ENST00000401412.1
ENST00000419304.2
AGR2
anterior gradient 2
chr6_+_151561085 1.05 ENST00000402676.2
AKAP12
A kinase (PRKA) anchor protein 12
chr4_+_95128748 1.02 ENST00000359052.4
SMARCAD1
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
chr14_+_102276132 0.96 ENST00000350249.3
ENST00000557621.1
ENST00000556946.1
PPP2R5C
protein phosphatase 2, regulatory subunit B', gamma
chr7_-_81635106 0.94 ENST00000443883.1
CACNA2D1
calcium channel, voltage-dependent, alpha 2/delta subunit 1
chr5_+_32788945 0.93 ENST00000326958.1
AC026703.1
AC026703.1
chr17_-_47786375 0.85 ENST00000511657.1
SLC35B1
solute carrier family 35, member B1
chr14_+_61449076 0.85 ENST00000526105.1
SLC38A6
solute carrier family 38, member 6
chr6_-_152639479 0.83 ENST00000356820.4
SYNE1
spectrin repeat containing, nuclear envelope 1
chr20_-_33735070 0.79 ENST00000374491.3
ENST00000542871.1
ENST00000374492.3
EDEM2
ER degradation enhancer, mannosidase alpha-like 2
chr13_+_78315295 0.79 ENST00000351546.3
SLAIN1
SLAIN motif family, member 1
chr10_-_74283694 0.77 ENST00000398763.4
ENST00000418483.2
ENST00000489666.2
MICU1
mitochondrial calcium uptake 1
chr6_+_26087509 0.77 ENST00000397022.3
ENST00000353147.5
ENST00000352392.4
ENST00000349999.4
ENST00000317896.7
ENST00000357618.5
ENST00000470149.1
ENST00000336625.8
ENST00000461397.1
ENST00000488199.1
HFE
hemochromatosis
chr11_-_92931098 0.76 ENST00000326402.4
SLC36A4
solute carrier family 36 (proton/amino acid symporter), member 4
chr2_-_190446738 0.74 ENST00000427419.1
ENST00000455320.1
SLC40A1
solute carrier family 40 (iron-regulated transporter), member 1
chrX_-_119077695 0.73 ENST00000371410.3
NKAP
NFKB activating protein
chrX_+_108779004 0.73 ENST00000218004.1
NXT2
nuclear transport factor 2-like export factor 2
chr14_+_61449197 0.71 ENST00000533744.2
SLC38A6
solute carrier family 38, member 6
chr10_-_27529486 0.71 ENST00000375888.1
ACBD5
acyl-CoA binding domain containing 5
chr5_+_140201183 0.70 ENST00000529619.1
ENST00000529859.1
ENST00000378126.3
PCDHA5
protocadherin alpha 5
chr17_-_33390667 0.68 ENST00000378516.2
ENST00000268850.7
ENST00000394597.2
RFFL
ring finger and FYVE-like domain containing E3 ubiquitin protein ligase
chr15_-_75748143 0.67 ENST00000568431.1
ENST00000568309.1
ENST00000568190.1
ENST00000570115.1
ENST00000564778.1
SIN3A
SIN3 transcription regulator family member A
chr8_+_38662960 0.67 ENST00000524193.1
TACC1
transforming, acidic coiled-coil containing protein 1
chr12_+_64798095 0.66 ENST00000332707.5
XPOT
exportin, tRNA
chr4_+_113568207 0.66 ENST00000511529.1
LARP7
La ribonucleoprotein domain family, member 7
chrX_-_55208866 0.64 ENST00000545075.1
MTRNR2L10
MT-RNR2-like 10
chr14_-_51027838 0.64 ENST00000555216.1
MAP4K5
mitogen-activated protein kinase kinase kinase kinase 5
chr19_-_3557570 0.63 ENST00000355415.2
MFSD12
major facilitator superfamily domain containing 12
chr7_-_45151272 0.62 ENST00000461363.1
ENST00000495078.1
ENST00000494076.1
ENST00000478532.1
ENST00000258770.3
ENST00000361278.3
TBRG4
transforming growth factor beta regulator 4
chr7_-_111032971 0.60 ENST00000450877.1
IMMP2L
IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae)
chr3_-_127455200 0.59 ENST00000398101.3
MGLL
monoglyceride lipase
chr13_+_78315348 0.59 ENST00000441784.1
SLAIN1
SLAIN motif family, member 1
chr2_-_136633940 0.57 ENST00000264156.2
MCM6
minichromosome maintenance complex component 6
chr4_+_156775910 0.57 ENST00000506072.1
ENST00000507590.1
TDO2
tryptophan 2,3-dioxygenase
chr4_+_15471489 0.56 ENST00000424120.1
ENST00000413206.1
ENST00000438599.2
ENST00000511544.1
ENST00000512702.1
ENST00000507954.1
ENST00000515124.1
ENST00000503292.1
ENST00000503658.1
CC2D2A
coiled-coil and C2 domain containing 2A
chr3_-_191000172 0.54 ENST00000427544.2
UTS2B
urotensin 2B
chr2_+_234580499 0.52 ENST00000354728.4
UGT1A9
UDP glucuronosyltransferase 1 family, polypeptide A9
chr2_+_234580525 0.51 ENST00000609637.1
UGT1A1
UDP glucuronosyltransferase 1 family, polypeptide A8
chr16_+_28565230 0.46 ENST00000317058.3
CCDC101
coiled-coil domain containing 101
chr7_-_37488777 0.45 ENST00000445322.1
ENST00000448602.1
ELMO1
engulfment and cell motility 1
chr1_-_190446759 0.45 ENST00000367462.3
BRINP3
bone morphogenetic protein/retinoic acid inducible neural-specific 3
chr11_-_62609281 0.45 ENST00000525239.1
ENST00000538098.2
WDR74
WD repeat domain 74
chr6_-_111804905 0.43 ENST00000358835.3
ENST00000435970.1
REV3L
REV3-like, polymerase (DNA directed), zeta, catalytic subunit
chr7_+_16700806 0.42 ENST00000446596.1
ENST00000438834.1
BZW2
basic leucine zipper and W2 domains 2
chr12_+_64798826 0.41 ENST00000540203.1
XPOT
exportin, tRNA
chr12_+_131438443 0.40 ENST00000261654.5
GPR133
G protein-coupled receptor 133
chr18_-_64271316 0.40 ENST00000540086.1
ENST00000580157.1
CDH19
cadherin 19, type 2
chr15_-_72563585 0.39 ENST00000287196.9
ENST00000260376.7
PARP6
poly (ADP-ribose) polymerase family, member 6
chr17_+_7155819 0.39 ENST00000570322.1
ENST00000576496.1
ENST00000574841.2
ELP5
elongator acetyltransferase complex subunit 5
chr17_-_4938712 0.39 ENST00000254853.5
ENST00000424747.1
SLC52A1
solute carrier family 52 (riboflavin transporter), member 1
chr8_-_121457608 0.38 ENST00000306185.3
MRPL13
mitochondrial ribosomal protein L13
chr7_-_37488834 0.37 ENST00000310758.4
ELMO1
engulfment and cell motility 1
chr7_+_13141010 0.35 ENST00000443947.1
AC011288.2
AC011288.2
chr5_-_130500922 0.34 ENST00000513012.1
ENST00000508488.1
ENST00000506908.1
ENST00000304043.5
HINT1
histidine triad nucleotide binding protein 1
chr2_+_234826016 0.34 ENST00000324695.4
ENST00000433712.2
TRPM8
transient receptor potential cation channel, subfamily M, member 8
chr2_-_217560248 0.33 ENST00000233813.4
IGFBP5
insulin-like growth factor binding protein 5
chr4_+_25162253 0.33 ENST00000512921.1
PI4K2B
phosphatidylinositol 4-kinase type 2 beta
chr2_-_145277569 0.33 ENST00000303660.4
ZEB2
zinc finger E-box binding homeobox 2
chr1_-_232651312 0.33 ENST00000262861.4
SIPA1L2
signal-induced proliferation-associated 1 like 2
chr15_+_58702742 0.31 ENST00000356113.6
ENST00000414170.3
LIPC
lipase, hepatic
chr5_+_68860949 0.30 ENST00000507595.1
GTF2H2C
general transcription factor IIH, polypeptide 2C
chr6_-_47445214 0.29 ENST00000604014.1
RP11-385F7.1
RP11-385F7.1
chr19_+_4402659 0.29 ENST00000301280.5
ENST00000585854.1
CHAF1A
chromatin assembly factor 1, subunit A (p150)
chr8_-_30706608 0.29 ENST00000256246.2
TEX15
testis expressed 15
chr1_-_160924589 0.28 ENST00000368029.3
ITLN2
intelectin 2
chr4_+_95128996 0.28 ENST00000457823.2
SMARCAD1
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
chr4_+_169418195 0.27 ENST00000261509.6
ENST00000335742.7
PALLD
palladin, cytoskeletal associated protein
chr15_+_48483736 0.27 ENST00000417307.2
ENST00000559641.1
CTXN2
SLC12A1
cortexin 2
solute carrier family 12 (sodium/potassium/chloride transporter), member 1
chr14_+_45605157 0.26 ENST00000542564.2
FANCM
Fanconi anemia, complementation group M
chr16_-_1538765 0.26 ENST00000447419.2
ENST00000440447.2
PTX4
pentraxin 4, long
chr1_+_171227069 0.25 ENST00000354841.4
FMO1
flavin containing monooxygenase 1
chr2_-_231860596 0.25 ENST00000441063.1
ENST00000434094.1
ENST00000418330.1
ENST00000457803.1
ENST00000414876.1
ENST00000446741.1
ENST00000426904.1
AC105344.2
SPATA3 antisense RNA 1 (head to head)
chr16_-_28937027 0.25 ENST00000358201.4
RABEP2
rabaptin, RAB GTPase binding effector protein 2
chr1_+_109265033 0.24 ENST00000445274.1
FNDC7
fibronectin type III domain containing 7
chr2_-_10587897 0.24 ENST00000405333.1
ENST00000443218.1
ODC1
ornithine decarboxylase 1
chr3_-_178103144 0.24 ENST00000417383.1
ENST00000418585.1
ENST00000411727.1
ENST00000439810.1
RP11-33A14.1
RP11-33A14.1
chr14_-_53258314 0.23 ENST00000216410.3
ENST00000557604.1
GNPNAT1
glucosamine-phosphate N-acetyltransferase 1
chr18_-_64271363 0.23 ENST00000262150.2
CDH19
cadherin 19, type 2
chr22_-_29107919 0.22 ENST00000434810.1
ENST00000456369.1
CHEK2
checkpoint kinase 2
chr17_-_3496171 0.21 ENST00000399756.4
TRPV1
transient receptor potential cation channel, subfamily V, member 1
chr16_-_3350614 0.21 ENST00000268674.2
TIGD7
tigger transposable element derived 7
chr12_-_118628315 0.21 ENST00000540561.1
TAOK3
TAO kinase 3
chr12_-_12715266 0.20 ENST00000228862.2
DUSP16
dual specificity phosphatase 16
chr1_-_223853425 0.19 ENST00000366873.2
ENST00000419193.2
CAPN8
calpain 8
chr12_-_58212487 0.19 ENST00000549994.1
AVIL
advillin
chr4_+_71108300 0.19 ENST00000304954.3
CSN3
casein kappa
chr8_+_92261516 0.18 ENST00000276609.3
ENST00000309536.2
SLC26A7
solute carrier family 26 (anion exchanger), member 7
chr13_+_24144509 0.18 ENST00000248484.4
TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr5_+_102200948 0.18 ENST00000511477.1
ENST00000506006.1
ENST00000509832.1
PAM
peptidylglycine alpha-amidating monooxygenase
chr1_+_152178320 0.18 ENST00000429352.1
RP11-107M16.2
RP11-107M16.2
chr14_-_74025625 0.18 ENST00000553558.1
ENST00000563329.1
ENST00000334988.2
ENST00000560393.1
HEATR4
HEAT repeat containing 4
chrX_-_21676442 0.17 ENST00000379499.2
KLHL34
kelch-like family member 34
chr1_-_174992544 0.17 ENST00000476371.1
MRPS14
mitochondrial ribosomal protein S14
chr2_-_40680578 0.16 ENST00000455476.1
SLC8A1
solute carrier family 8 (sodium/calcium exchanger), member 1
chr13_+_24144796 0.15 ENST00000403372.2
TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr11_+_28129795 0.15 ENST00000406787.3
ENST00000342303.5
ENST00000403099.1
ENST00000407364.3
METTL15
methyltransferase like 15
chr15_-_75748115 0.15 ENST00000360439.4
SIN3A
SIN3 transcription regulator family member A
chr11_-_74800799 0.15 ENST00000305159.3
OR2AT4
olfactory receptor, family 2, subfamily AT, member 4
chr12_-_95945246 0.15 ENST00000258499.3
USP44
ubiquitin specific peptidase 44
chr3_-_20053741 0.14 ENST00000389050.4
PP2D1
protein phosphatase 2C-like domain containing 1
chr4_-_138453606 0.14 ENST00000412923.2
ENST00000344876.4
ENST00000507846.1
ENST00000510305.1
PCDH18
protocadherin 18
chr4_-_120243545 0.13 ENST00000274024.3
FABP2
fatty acid binding protein 2, intestinal
chr1_-_202897724 0.13 ENST00000435533.3
ENST00000367258.1
KLHL12
kelch-like family member 12
chr2_-_217559517 0.13 ENST00000449583.1
IGFBP5
insulin-like growth factor binding protein 5
chr10_+_63422695 0.13 ENST00000330194.2
ENST00000389639.3
C10orf107
chromosome 10 open reading frame 107
chr5_-_68339648 0.12 ENST00000479830.2
CTC-498J12.1
CTC-498J12.1
chr10_-_95242044 0.12 ENST00000371501.4
ENST00000371502.4
ENST00000371489.1
MYOF
myoferlin
chrX_+_65382381 0.12 ENST00000519389.1
HEPH
hephaestin
chr4_-_48116540 0.12 ENST00000506073.1
TXK
TXK tyrosine kinase
chr9_-_28670283 0.11 ENST00000379992.2
LINGO2
leucine rich repeat and Ig domain containing 2
chr3_-_157221380 0.11 ENST00000468233.1
VEPH1
ventricular zone expressed PH domain-containing 1
chr21_-_30445886 0.11 ENST00000431234.1
ENST00000540844.1
ENST00000286788.4
CCT8
chaperonin containing TCP1, subunit 8 (theta)
chr9_-_95298254 0.11 ENST00000444490.2
ECM2
extracellular matrix protein 2, female organ and adipocyte specific
chr11_+_71544246 0.11 ENST00000328698.1
DEFB108B
defensin, beta 108B
chr17_-_39156138 0.11 ENST00000391587.1
KRTAP3-2
keratin associated protein 3-2
chr11_+_73498898 0.11 ENST00000535529.1
ENST00000497094.2
ENST00000411840.2
ENST00000535277.1
ENST00000398483.3
ENST00000542303.1
MRPL48
mitochondrial ribosomal protein L48
chr3_+_138327542 0.10 ENST00000360570.3
ENST00000393035.2
FAIM
Fas apoptotic inhibitory molecule
chr5_-_173217931 0.10 ENST00000522731.1
CTB-43E15.4
CTB-43E15.4
chr19_+_3185910 0.10 ENST00000588428.1
NCLN
nicalin
chr4_-_19458597 0.10 ENST00000505347.1
RP11-3J1.1
RP11-3J1.1
chr7_+_141811539 0.10 ENST00000550469.2
ENST00000477922.3
RP11-1220K2.2
Putative inactive maltase-glucoamylase-like protein LOC93432
chr9_-_95166841 0.10 ENST00000262551.4
OGN
osteoglycin
chr9_+_35042205 0.09 ENST00000312292.5
ENST00000378745.3
C9orf131
chromosome 9 open reading frame 131
chr13_+_49551020 0.09 ENST00000541916.1
FNDC3A
fibronectin type III domain containing 3A
chrX_-_84634737 0.09 ENST00000262753.4
POF1B
premature ovarian failure, 1B
chr18_-_3845321 0.08 ENST00000539435.1
ENST00000400147.2
DLGAP1
discs, large (Drosophila) homolog-associated protein 1
chrX_+_55478538 0.08 ENST00000342972.1
MAGEH1
melanoma antigen family H, 1
chr5_+_57787254 0.08 ENST00000502276.1
ENST00000396776.2
ENST00000511930.1
GAPT
GRB2-binding adaptor protein, transmembrane
chr5_-_54988448 0.08 ENST00000503817.1
ENST00000512595.1
SLC38A9
solute carrier family 38, member 9
chr3_+_138327417 0.08 ENST00000338446.4
FAIM
Fas apoptotic inhibitory molecule
chr12_-_110937351 0.08 ENST00000552130.2
VPS29
vacuolar protein sorting 29 homolog (S. cerevisiae)
chr2_-_85108363 0.08 ENST00000335459.5
TRABD2A
TraB domain containing 2A
chr14_-_90798273 0.08 ENST00000357904.3
NRDE2
NRDE-2, necessary for RNA interference, domain containing
chr16_+_53133070 0.08 ENST00000565832.1
CHD9
chromodomain helicase DNA binding protein 9
chr12_-_49581152 0.07 ENST00000550811.1
TUBA1A
tubulin, alpha 1a
chr12_+_26164645 0.07 ENST00000542004.1
RASSF8
Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
chr11_-_63376013 0.07 ENST00000540943.1
PLA2G16
phospholipase A2, group XVI
chr11_+_12132117 0.07 ENST00000256194.4
MICAL2
microtubule associated monooxygenase, calponin and LIM domain containing 2
chr15_+_64680003 0.07 ENST00000261884.3
TRIP4
thyroid hormone receptor interactor 4
chr11_-_107729287 0.06 ENST00000375682.4
SLC35F2
solute carrier family 35, member F2
chrX_+_65382433 0.06 ENST00000374727.3
HEPH
hephaestin
chr4_+_74576019 0.06 ENST00000436089.1
AC112518.3
AC112518.3
chr2_-_166060382 0.06 ENST00000409101.3
SCN3A
sodium channel, voltage-gated, type III, alpha subunit
chr19_+_29456034 0.06 ENST00000589921.1
LINC00906
long intergenic non-protein coding RNA 906
chr6_+_161123270 0.06 ENST00000366924.2
ENST00000308192.9
ENST00000418964.1
PLG
plasminogen
chr15_+_51669513 0.06 ENST00000558426.1
GLDN
gliomedin
chr19_-_46234119 0.06 ENST00000317683.3
FBXO46
F-box protein 46
chr18_+_61575200 0.05 ENST00000238508.3
SERPINB10
serpin peptidase inhibitor, clade B (ovalbumin), member 10
chr6_+_53964336 0.05 ENST00000447836.2
ENST00000511678.1
MLIP
muscular LMNA-interacting protein
chr15_+_78370140 0.05 ENST00000409568.2
SH2D7
SH2 domain containing 7
chrX_-_84634708 0.04 ENST00000373145.3
POF1B
premature ovarian failure, 1B
chr1_+_151253991 0.04 ENST00000443959.1
ZNF687
zinc finger protein 687
chr4_+_169418255 0.04 ENST00000505667.1
ENST00000511948.1
PALLD
palladin, cytoskeletal associated protein
chr4_+_147145709 0.04 ENST00000504313.1
RP11-6L6.2
Uncharacterized protein
chr21_-_39705323 0.03 ENST00000436845.1
AP001422.3
AP001422.3
chr6_+_31105426 0.03 ENST00000547221.1
PSORS1C1
psoriasis susceptibility 1 candidate 1
chrX_-_100872911 0.03 ENST00000361910.4
ENST00000539247.1
ENST00000538627.1
ARMCX6
armadillo repeat containing, X-linked 6
chr9_+_111624577 0.02 ENST00000333999.3
ACTL7A
actin-like 7A
chr11_+_113779704 0.02 ENST00000537778.1
HTR3B
5-hydroxytryptamine (serotonin) receptor 3B, ionotropic
chr2_+_128177253 0.02 ENST00000427769.1
PROC
protein C (inactivator of coagulation factors Va and VIIIa)
chr11_-_107729504 0.02 ENST00000265836.7
SLC35F2
solute carrier family 35, member F2
chr9_-_99540328 0.02 ENST00000223428.4
ENST00000375231.1
ENST00000374641.3
ZNF510
zinc finger protein 510
chr1_-_13390765 0.01 ENST00000357367.2
PRAMEF8
PRAME family member 8
chr5_+_40909354 0.01 ENST00000313164.9
C7
complement component 7
chr19_-_51920952 0.01 ENST00000356298.5
ENST00000339313.5
ENST00000529627.1
ENST00000439889.2
ENST00000353836.5
ENST00000432469.2
SIGLEC10
sialic acid binding Ig-like lectin 10
chr2_+_74685413 0.01 ENST00000233615.2
WBP1
WW domain binding protein 1
chr4_-_122085469 0.01 ENST00000057513.3
TNIP3
TNFAIP3 interacting protein 3
chr6_+_42989344 0.01 ENST00000244496.5
RRP36
ribosomal RNA processing 36 homolog (S. cerevisiae)
chr17_-_7307358 0.00 ENST00000576017.1
ENST00000302422.3
ENST00000535512.1
TMEM256
TMEM256-PLSCR3
transmembrane protein 256
TMEM256-PLSCR3 readthrough (NMD candidate)

Network of associatons between targets according to the STRING database.

First level regulatory network of ISL2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0002590 regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002589) negative regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002590) positive regulation of iron ion transport(GO:0034758) positive regulation of iron ion transmembrane transport(GO:0034761) regulation of iron ion import(GO:1900390) regulation of ferrous iron import into cell(GO:1903989) positive regulation of ferrous iron import into cell(GO:1903991) regulation of ferrous iron binding(GO:1904432) positive regulation of ferrous iron binding(GO:1904434) regulation of transferrin receptor binding(GO:1904435) positive regulation of transferrin receptor binding(GO:1904437) regulation of ferrous iron import across plasma membrane(GO:1904438) positive regulation of ferrous iron import across plasma membrane(GO:1904440) response to iron ion starvation(GO:1990641)
0.2 0.7 GO:0060345 spleen trabecula formation(GO:0060345) iron cation export(GO:1903414) ferrous iron export(GO:1903988)
0.2 0.9 GO:0072334 UDP-galactose transport(GO:0015785) UDP-galactose transmembrane transport(GO:0072334)
0.2 0.6 GO:0061300 cerebellum vasculature development(GO:0061300)
0.2 2.3 GO:0034392 negative regulation of smooth muscle cell apoptotic process(GO:0034392)
0.2 1.4 GO:0009753 response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395)
0.2 0.8 GO:1901675 negative regulation of histone H3-K27 acetylation(GO:1901675)
0.2 0.8 GO:0036511 trimming of terminal mannose on B branch(GO:0036509) trimming of first mannose on A branch(GO:0036511) trimming of second mannose on A branch(GO:0036512)
0.2 0.5 GO:1904204 regulation of skeletal muscle hypertrophy(GO:1904204)
0.2 1.1 GO:1903899 lung goblet cell differentiation(GO:0060480) positive regulation of PERK-mediated unfolded protein response(GO:1903899)
0.1 0.6 GO:0019442 tryptophan catabolic process to acetyl-CoA(GO:0019442)
0.1 2.2 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.1 0.9 GO:0086048 membrane depolarization during bundle of His cell action potential(GO:0086048)
0.1 0.7 GO:2001271 negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.1 1.8 GO:0072520 seminiferous tubule development(GO:0072520)
0.1 1.4 GO:1901078 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 2.0 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.1 0.6 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.1 0.6 GO:1904491 protein localization to ciliary transition zone(GO:1904491)
0.1 0.6 GO:0050955 thermoception(GO:0050955)
0.1 0.7 GO:0030242 pexophagy(GO:0030242)
0.1 0.4 GO:0032218 riboflavin transport(GO:0032218)
0.1 0.8 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.1 0.8 GO:0015808 L-alanine transport(GO:0015808)
0.1 1.1 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.1 0.2 GO:1903926 signal transduction involved in intra-S DNA damage checkpoint(GO:0072428) response to bisphenol A(GO:1903925) cellular response to bisphenol A(GO:1903926)
0.1 1.3 GO:0070933 histone H4 deacetylation(GO:0070933)
0.0 0.2 GO:0045209 MAPK phosphatase export from nucleus(GO:0045208) MAPK phosphatase export from nucleus, leptomycin B sensitive(GO:0045209)
0.0 0.8 GO:0090292 nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0 0.6 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.0 0.2 GO:0033387 putrescine biosynthetic process from ornithine(GO:0033387)
0.0 0.4 GO:0051552 flavone metabolic process(GO:0051552)
0.0 0.3 GO:1902748 positive regulation of lens fiber cell differentiation(GO:1902748)
0.0 1.4 GO:0045880 positive regulation of smoothened signaling pathway(GO:0045880)
0.0 0.2 GO:0006041 glucosamine metabolic process(GO:0006041)
0.0 0.2 GO:0018032 protein amidation(GO:0018032)
0.0 0.3 GO:0070995 NADPH oxidation(GO:0070995)
0.0 0.3 GO:0006335 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.0 0.3 GO:0034372 very-low-density lipoprotein particle remodeling(GO:0034372)
0.0 0.1 GO:1904806 regulation of protein oxidation(GO:1904806) positive regulation of protein oxidation(GO:1904808)
0.0 0.1 GO:0070475 rRNA base methylation(GO:0070475)
0.0 0.1 GO:0051919 positive regulation of fibrinolysis(GO:0051919)
0.0 0.6 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.0 0.1 GO:0019417 sulfur oxidation(GO:0019417)
0.0 0.1 GO:0060332 positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335)
0.0 1.1 GO:0071431 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.0 0.7 GO:0071425 hematopoietic stem cell proliferation(GO:0071425)
0.0 0.2 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
0.0 1.2 GO:0050919 negative chemotaxis(GO:0050919)
0.0 0.1 GO:0034334 adherens junction maintenance(GO:0034334)
0.0 1.1 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.0 0.3 GO:0000712 resolution of meiotic recombination intermediates(GO:0000712)
0.0 0.3 GO:0003334 keratinocyte development(GO:0003334)
0.0 0.4 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.0 0.8 GO:0016601 Rac protein signal transduction(GO:0016601)
0.0 0.1 GO:0002322 B cell proliferation involved in immune response(GO:0002322)
0.0 1.4 GO:0003333 amino acid transmembrane transport(GO:0003333)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.5 GO:0097149 centralspindlin complex(GO:0097149)
0.2 0.7 GO:0002947 tumor necrosis factor receptor superfamily complex(GO:0002947)
0.2 0.6 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.1 0.8 GO:1990246 uniplex complex(GO:1990246)
0.1 2.3 GO:0031089 platelet dense granule lumen(GO:0031089)
0.1 1.4 GO:0060091 kinocilium(GO:0060091)
0.1 1.8 GO:0005828 kinetochore microtubule(GO:0005828)
0.1 0.8 GO:1990357 terminal web(GO:1990357)
0.1 0.3 GO:0071821 FANCM-MHF complex(GO:0071821)
0.1 0.3 GO:0033186 CAF-1 complex(GO:0033186)
0.1 0.4 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.1 2.2 GO:0043194 axon initial segment(GO:0043194)
0.1 0.9 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 0.5 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.0 1.4 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.4 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 0.8 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.6 GO:0036038 MKS complex(GO:0036038)
0.0 0.6 GO:0042555 MCM complex(GO:0042555)
0.0 0.8 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.3 GO:0000439 core TFIIH complex(GO:0000439)
0.0 1.3 GO:0035861 site of double-strand break(GO:0035861)
0.0 1.0 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.6 GO:0016580 Sin3 complex(GO:0016580)
0.0 0.1 GO:0030906 retromer, cargo-selective complex(GO:0030906)
0.0 0.8 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.0 0.4 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 0.9 GO:0030173 integral component of Golgi membrane(GO:0030173)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.3 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.3 0.9 GO:0086057 voltage-gated calcium channel activity involved in bundle of His cell action potential(GO:0086057)
0.2 0.7 GO:0097689 iron channel activity(GO:0097689)
0.2 0.9 GO:0005459 UDP-galactose transmembrane transporter activity(GO:0005459)
0.2 1.4 GO:0047086 phenanthrene 9,10-monooxygenase activity(GO:0018636) ketosteroid monooxygenase activity(GO:0047086)
0.2 0.8 GO:0015173 aromatic amino acid transmembrane transporter activity(GO:0015173)
0.1 0.6 GO:0004833 tryptophan 2,3-dioxygenase activity(GO:0004833)
0.1 0.3 GO:0008511 sodium:potassium:chloride symporter activity(GO:0008511)
0.1 0.8 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.1 2.3 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.1 0.4 GO:0032217 riboflavin transporter activity(GO:0032217)
0.1 1.1 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.1 0.8 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.1 1.1 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 1.8 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.3 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.0 0.5 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 0.6 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.3 GO:0070087 chromo shadow domain binding(GO:0070087)
0.0 1.4 GO:0043015 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) gamma-tubulin binding(GO:0043015)
0.0 0.2 GO:0004504 peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598)
0.0 0.3 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0 0.1 GO:0070052 collagen V binding(GO:0070052)
0.0 1.2 GO:0038191 neuropilin binding(GO:0038191)
0.0 0.2 GO:0097603 temperature-gated ion channel activity(GO:0097603)
0.0 0.6 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 0.1 GO:0016434 rRNA (cytosine) methyltransferase activity(GO:0016434)
0.0 0.2 GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580)
0.0 0.7 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.0 0.8 GO:0005521 lamin binding(GO:0005521)
0.0 0.1 GO:1904854 proteasome core complex binding(GO:1904854)
0.0 1.1 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 0.1 GO:0052740 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740)
0.0 0.8 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 0.4 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 0.3 GO:0034185 apolipoprotein binding(GO:0034185)
0.0 2.0 GO:0017048 Rho GTPase binding(GO:0017048)
0.0 0.2 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.1 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 3.7 PID PLK1 PATHWAY PLK1 signaling events
0.0 1.1 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 1.3 PID TNF PATHWAY TNF receptor signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.2 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 1.8 REACTOME KINESINS Genes involved in Kinesins
0.0 0.8 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 1.0 REACTOME CTNNB1 PHOSPHORYLATION CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.0 0.6 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.0 0.6 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.6 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.0 2.5 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 1.4 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 0.5 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.9 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 0.3 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.4 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.2 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 0.8 REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.0 0.3 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport