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SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for JDP2
Z-value: 2.15
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Transcription factors associated with JDP2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| JDP2 | hg19_v2_chr14_+_75894391_75894435 | 0.37 | 1.0e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of JDP2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 18.2 | GO:0051599 | response to hydrostatic pressure(GO:0051599) |
| 1.2 | 17.6 | GO:0090385 | phagosome-lysosome fusion(GO:0090385) |
| 0.2 | 13.7 | GO:0061718 | NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718) |
| 0.8 | 12.4 | GO:0070307 | lens fiber cell development(GO:0070307) |
| 2.3 | 11.3 | GO:0035105 | sterol regulatory element binding protein import into nucleus(GO:0035105) |
| 0.5 | 11.2 | GO:0070493 | thrombin receptor signaling pathway(GO:0070493) |
| 1.8 | 10.9 | GO:0015722 | canalicular bile acid transport(GO:0015722) |
| 0.5 | 10.8 | GO:0044849 | estrous cycle(GO:0044849) |
| 0.8 | 10.0 | GO:0061087 | positive regulation of histone H3-K27 methylation(GO:0061087) |
| 0.4 | 9.8 | GO:1904714 | regulation of chaperone-mediated autophagy(GO:1904714) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 18.7 | GO:0030670 | phagocytic vesicle membrane(GO:0030670) |
| 0.1 | 18.3 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.4 | 18.2 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 1.5 | 13.4 | GO:0000015 | phosphopyruvate hydratase complex(GO:0000015) |
| 1.1 | 11.3 | GO:0005638 | lamin filament(GO:0005638) |
| 0.2 | 10.0 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
| 0.7 | 9.5 | GO:0005853 | eukaryotic translation elongation factor 1 complex(GO:0005853) |
| 0.5 | 7.8 | GO:0034366 | spherical high-density lipoprotein particle(GO:0034366) |
| 0.0 | 7.4 | GO:0036464 | cytoplasmic ribonucleoprotein granule(GO:0036464) |
| 0.3 | 6.6 | GO:0005915 | zonula adherens(GO:0005915) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 18.2 | GO:0097110 | scaffold protein binding(GO:0097110) |
| 0.6 | 17.6 | GO:0017160 | Ral GTPase binding(GO:0017160) |
| 1.5 | 13.4 | GO:0004634 | phosphopyruvate hydratase activity(GO:0004634) |
| 0.0 | 12.3 | GO:0004674 | protein serine/threonine kinase activity(GO:0004674) |
| 1.6 | 11.2 | GO:0015057 | thrombin receptor activity(GO:0015057) |
| 3.6 | 10.9 | GO:0015432 | bile acid-exporting ATPase activity(GO:0015432) |
| 0.1 | 10.0 | GO:0035064 | methylated histone binding(GO:0035064) |
| 0.3 | 9.5 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 0.2 | 9.5 | GO:0046875 | ephrin receptor binding(GO:0046875) |
| 1.3 | 8.0 | GO:0008853 | exodeoxyribonuclease III activity(GO:0008853) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 18.1 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.1 | 13.3 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.5 | 11.2 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
| 0.1 | 10.0 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.0 | 8.8 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 8.3 | ST TUMOR NECROSIS FACTOR PATHWAY | Tumor Necrosis Factor Pathway. |
| 0.1 | 8.1 | PID E2F PATHWAY | E2F transcription factor network |
| 0.1 | 7.8 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.1 | 7.4 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 6.5 | SA B CELL RECEPTOR COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 13.7 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.2 | 12.2 | REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS | Genes involved in Thrombin signalling through proteinase activated receptors (PARs) |
| 0.1 | 12.2 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.6 | 10.9 | REACTOME RECYCLING OF BILE ACIDS AND SALTS | Genes involved in Recycling of bile acids and salts |
| 0.2 | 10.5 | REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.2 | 10.1 | REACTOME SYNTHESIS OF PA | Genes involved in Synthesis of PA |
| 0.0 | 8.5 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.0 | 7.8 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.1 | 6.9 | REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
| 0.3 | 6.8 | REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10 | Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 |