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SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for JUND
Z-value: 1.13
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Transcription factors associated with JUND
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| JUND | hg19_v2_chr19_-_18391708_18391739 | 0.92 | 1.2e-08 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr21_-_43786634 Show fit | 5.80 |
ENST00000291527.2
|
trefoil factor 1 |
|
| chr17_+_25799008 Show fit | 4.84 |
ENST00000583370.1
ENST00000398988.3 ENST00000268763.6 |
kinase suppressor of ras 1 |
|
| chr16_+_57844549 Show fit | 4.71 |
ENST00000564282.1
|
uncharacterized protein LOC388282 |
|
| chr12_+_52695617 Show fit | 4.37 |
ENST00000293525.5
|
keratin 86 |
|
| chr20_-_62129163 Show fit | 4.35 |
ENST00000298049.7
|
eukaryotic translation elongation factor 1 alpha 2 |
|
| chr11_+_67250490 Show fit | 3.41 |
ENST00000528641.2
ENST00000279146.3 |
aryl hydrocarbon receptor interacting protein |
|
| chr8_-_27472198 Show fit | 3.31 |
ENST00000519472.1
ENST00000523589.1 ENST00000522413.1 ENST00000523396.1 ENST00000560366.1 |
clusterin |
|
| chr4_-_89079817 Show fit | 3.17 |
ENST00000505480.1
|
ATP-binding cassette, sub-family G (WHITE), member 2 |
|
| chr10_+_17270214 Show fit | 3.07 |
ENST00000544301.1
|
vimentin |
|
| chr15_+_59903975 Show fit | 3.00 |
ENST00000560585.1
ENST00000396065.1 |
glucosaminyl (N-acetyl) transferase 3, mucin type |
Network of associatons between targets according to the STRING database.
First level regulatory network of JUND
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 6.6 | GO:0051599 | response to hydrostatic pressure(GO:0051599) |
| 0.2 | 5.8 | GO:0030277 | maintenance of gastrointestinal epithelium(GO:0030277) |
| 0.8 | 5.6 | GO:0071725 | toll-like receptor TLR1:TLR2 signaling pathway(GO:0038123) response to triacyl bacterial lipopeptide(GO:0071725) cellular response to triacyl bacterial lipopeptide(GO:0071727) |
| 0.0 | 5.2 | GO:0007098 | centrosome cycle(GO:0007098) |
| 0.9 | 5.1 | GO:0061143 | alveolar primary septum development(GO:0061143) |
| 0.3 | 5.1 | GO:0070307 | lens fiber cell development(GO:0070307) |
| 0.0 | 4.8 | GO:0019933 | cAMP-mediated signaling(GO:0019933) |
| 0.2 | 4.3 | GO:1904714 | regulation of chaperone-mediated autophagy(GO:1904714) |
| 0.3 | 3.8 | GO:0014722 | regulation of skeletal muscle contraction by calcium ion signaling(GO:0014722) |
| 0.4 | 3.4 | GO:0051342 | regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051342) negative regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051344) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 6.6 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.6 | 5.6 | GO:0046696 | lipopolysaccharide receptor complex(GO:0046696) |
| 0.4 | 5.3 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.4 | 5.2 | GO:0070652 | HAUS complex(GO:0070652) |
| 0.1 | 4.9 | GO:0045095 | keratin filament(GO:0045095) |
| 0.0 | 4.6 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.0 | 4.4 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.3 | 4.3 | GO:0005853 | eukaryotic translation elongation factor 1 complex(GO:0005853) |
| 0.1 | 4.3 | GO:0031307 | integral component of mitochondrial outer membrane(GO:0031307) |
| 0.0 | 4.2 | GO:0015030 | Cajal body(GO:0015030) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.0 | GO:0097110 | scaffold protein binding(GO:0097110) |
| 0.8 | 5.6 | GO:0016019 | peptidoglycan receptor activity(GO:0016019) |
| 0.1 | 5.1 | GO:0051183 | vitamin transporter activity(GO:0051183) |
| 0.0 | 4.9 | GO:0031072 | heat shock protein binding(GO:0031072) |
| 0.3 | 4.8 | GO:0005078 | MAP-kinase scaffold activity(GO:0005078) |
| 0.1 | 4.3 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 0.0 | 4.2 | GO:0008083 | growth factor activity(GO:0008083) |
| 0.0 | 3.6 | GO:0048365 | Rac GTPase binding(GO:0048365) |
| 0.2 | 3.4 | GO:0017162 | aryl hydrocarbon receptor binding(GO:0017162) |
| 0.1 | 3.3 | GO:0051787 | misfolded protein binding(GO:0051787) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.6 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.1 | 6.4 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.1 | 6.4 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 4.8 | PID CERAMIDE PATHWAY | Ceramide signaling pathway |
| 0.0 | 3.3 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.1 | 3.2 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.0 | 3.1 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 2.0 | PID INTEGRIN CS PATHWAY | Integrin family cell surface interactions |
| 0.0 | 2.0 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.0 | 1.5 | PID RHOA PATHWAY | RhoA signaling pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 5.6 | REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 | Genes involved in IKK complex recruitment mediated by RIP1 |
| 0.2 | 3.2 | REACTOME ABACAVIR TRANSPORT AND METABOLISM | Genes involved in Abacavir transport and metabolism |
| 0.1 | 3.1 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.0 | 3.0 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.0 | 3.0 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.1 | 2.7 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |
| 0.0 | 2.7 | REACTOME O LINKED GLYCOSYLATION OF MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.0 | 2.0 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.0 | 1.7 | REACTOME EXTENSION OF TELOMERES | Genes involved in Extension of Telomeres |
| 0.0 | 1.5 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |