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SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for KLF1

Z-value: 4.02

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Transcription factors associated with KLF1

Gene Symbol Gene ID Gene Info
KLF1
ENSG00000105610.4 Kruppel like factor 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
KLF1hg19_v2_chr19_-_12997995_12998021-0.029.5e-01Click!

Activity profile of KLF1 motif

Sorted Z-values of KLF1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr16_-_31147020 25.33 ENST00000568261.1
ENST00000567797.1
ENST00000317508.6
PRSS8
protease, serine, 8
chr17_-_39661849 23.23 ENST00000246635.3
ENST00000336861.3
ENST00000587544.1
ENST00000587435.1
KRT13
keratin 13
chr15_+_43885252 19.29 ENST00000453782.1
ENST00000300283.6
ENST00000437924.1
ENST00000450086.2
CKMT1B
creatine kinase, mitochondrial 1B
chr15_+_43985084 18.55 ENST00000434505.1
ENST00000411750.1
CKMT1A
creatine kinase, mitochondrial 1A
chr19_+_35607166 16.99 ENST00000604255.1
ENST00000346446.5
ENST00000344013.6
ENST00000603449.1
ENST00000406988.1
ENST00000605550.1
ENST00000604804.1
ENST00000605552.1
FXYD3
FXYD domain containing ion transport regulator 3
chr8_-_143867946 16.12 ENST00000301263.4
LY6D
lymphocyte antigen 6 complex, locus D
chr16_+_55600580 15.85 ENST00000457326.2
CAPNS2
calpain, small subunit 2
chr18_+_29027696 15.75 ENST00000257189.4
DSG3
desmoglein 3
chr19_+_35606777 15.69 ENST00000604404.1
ENST00000435734.2
ENST00000603181.1
FXYD3
FXYD domain containing ion transport regulator 3
chr1_+_209602156 15.47 ENST00000429156.1
ENST00000366437.3
ENST00000603283.1
ENST00000431096.1
MIR205HG
MIR205 host gene (non-protein coding)
chr17_-_39661947 15.19 ENST00000590425.1
KRT13
keratin 13
chr1_+_35225339 15.14 ENST00000339480.1
GJB4
gap junction protein, beta 4, 30.3kDa
chr12_+_7072354 14.80 ENST00000537269.1
U47924.27
U47924.27
chr1_-_27816556 14.75 ENST00000536657.1
WASF2
WAS protein family, member 2
chr17_+_46126135 14.39 ENST00000361665.3
ENST00000585062.1
NFE2L1
nuclear factor, erythroid 2-like 1
chr17_+_46125685 14.36 ENST00000579889.1
NFE2L1
nuclear factor, erythroid 2-like 1
chr17_-_7166500 14.23 ENST00000575313.1
ENST00000397317.4
CLDN7
claudin 7
chr16_-_31146961 14.06 ENST00000567531.1
PRSS8
protease, serine, 8
chr19_+_35606692 12.57 ENST00000406242.3
ENST00000454903.2
FXYD3
FXYD domain containing ion transport regulator 3
chr17_+_46125707 12.37 ENST00000584137.1
ENST00000362042.3
ENST00000585291.1
ENST00000357480.5
NFE2L1
nuclear factor, erythroid 2-like 1
chr17_-_7493390 12.07 ENST00000538513.2
ENST00000570788.1
ENST00000250055.2
SOX15
SRY (sex determining region Y)-box 15
chr19_-_51522955 11.88 ENST00000358789.3
KLK10
kallikrein-related peptidase 10
chr8_-_101963482 11.10 ENST00000419477.2
YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
chr10_-_47173994 11.09 ENST00000414655.2
ENST00000545298.1
ENST00000359178.4
ENST00000358140.4
ENST00000503031.1
ANXA8L1
LINC00842
annexin A8-like 1
long intergenic non-protein coding RNA 842
chr1_-_39395165 11.03 ENST00000372985.3
RHBDL2
rhomboid, veinlet-like 2 (Drosophila)
chr2_-_166651152 10.93 ENST00000431484.1
ENST00000412248.1
GALNT3
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)
chr4_-_90756769 10.65 ENST00000345009.4
ENST00000505199.1
ENST00000502987.1
SNCA
synuclein, alpha (non A4 component of amyloid precursor)
chr15_+_90931450 10.55 ENST00000268182.5
ENST00000560738.1
ENST00000560418.1
IQGAP1
IQ motif containing GTPase activating protein 1
chr2_-_166651191 10.47 ENST00000392701.3
GALNT3
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)
chr1_-_27816641 10.37 ENST00000430629.2
WASF2
WAS protein family, member 2
chr19_-_51523412 10.36 ENST00000391805.1
ENST00000599077.1
KLK10
kallikrein-related peptidase 10
chr2_-_219151487 10.27 ENST00000444881.1
TMBIM1
transmembrane BAX inhibitor motif containing 1
chrX_-_48326764 10.23 ENST00000413668.1
ENST00000441948.1
SLC38A5
solute carrier family 38, member 5
chr2_+_173292301 10.12 ENST00000264106.6
ENST00000375221.2
ENST00000343713.4
ITGA6
integrin, alpha 6
chr9_+_71736177 10.00 ENST00000606364.1
ENST00000453658.2
TJP2
tight junction protein 2
chrX_-_3264682 9.98 ENST00000217939.6
MXRA5
matrix-remodelling associated 5
chr2_-_219151984 9.82 ENST00000444000.1
ENST00000418569.1
TMBIM1
transmembrane BAX inhibitor motif containing 1
chr17_+_46131912 9.81 ENST00000584634.1
ENST00000580050.1
NFE2L1
nuclear factor, erythroid 2-like 1
chr11_-_62313090 9.70 ENST00000528508.1
ENST00000533365.1
AHNAK
AHNAK nucleoprotein
chr19_-_36004543 9.46 ENST00000339686.3
ENST00000447113.2
ENST00000440396.1
DMKN
dermokine
chr10_+_47746929 9.42 ENST00000340243.6
ENST00000374277.5
ENST00000449464.2
ENST00000538825.1
ENST00000335083.5
ANXA8L2
AL603965.1
annexin A8-like 2
Protein LOC100996760
chr17_-_34122596 9.30 ENST00000250144.8
MMP28
matrix metallopeptidase 28
chr1_-_26680570 9.27 ENST00000475866.2
AIM1L
absent in melanoma 1-like
chr14_+_24867992 9.25 ENST00000382554.3
NYNRIN
NYN domain and retroviral integrase containing
chr3_+_50192457 9.18 ENST00000414301.1
ENST00000450338.1
SEMA3F
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
chr19_-_51523275 9.06 ENST00000309958.3
KLK10
kallikrein-related peptidase 10
chr2_+_173292390 9.02 ENST00000442250.1
ENST00000458358.1
ENST00000409080.1
ITGA6
integrin, alpha 6
chr6_+_41606176 8.91 ENST00000441667.1
ENST00000230321.6
ENST00000373050.4
ENST00000446650.1
ENST00000435476.1
MDFI
MyoD family inhibitor
chr6_+_30850862 8.83 ENST00000504651.1
ENST00000512694.1
ENST00000515233.1
DDR1
discoidin domain receptor tyrosine kinase 1
chr1_+_36771946 8.79 ENST00000373139.2
ENST00000453908.2
ENST00000426732.2
SH3D21
SH3 domain containing 21
chr11_-_73471655 8.74 ENST00000400470.2
RAB6A
RAB6A, member RAS oncogene family
chr6_+_30850697 8.65 ENST00000509639.1
ENST00000412274.2
ENST00000507901.1
ENST00000507046.1
ENST00000437124.2
ENST00000454612.2
ENST00000396342.2
DDR1
discoidin domain receptor tyrosine kinase 1
chr17_+_46131843 8.53 ENST00000577411.1
NFE2L1
nuclear factor, erythroid 2-like 1
chr14_-_23623577 8.28 ENST00000422941.2
ENST00000453702.1
SLC7A8
solute carrier family 7 (amino acid transporter light chain, L system), member 8
chr18_-_28682374 8.18 ENST00000280904.6
DSC2
desmocollin 2
chr18_+_21452804 8.12 ENST00000269217.6
LAMA3
laminin, alpha 3
chr1_+_44399347 8.02 ENST00000477048.1
ENST00000471394.2
ARTN
artemin
chr19_+_39687596 7.98 ENST00000339852.4
NCCRP1
non-specific cytotoxic cell receptor protein 1 homolog (zebrafish)
chr18_+_21452964 7.95 ENST00000587184.1
LAMA3
laminin, alpha 3
chr7_+_134430212 7.94 ENST00000436461.2
CALD1
caldesmon 1
chr2_+_17721920 7.93 ENST00000295156.4
VSNL1
visinin-like 1
chr2_+_173292280 7.84 ENST00000264107.7
ITGA6
integrin, alpha 6
chr16_+_67233007 7.75 ENST00000360833.1
ENST00000393997.2
ELMO3
engulfment and cell motility 3
chr3_-_195538760 7.71 ENST00000475231.1
MUC4
mucin 4, cell surface associated
chr17_+_46132037 7.70 ENST00000582155.1
ENST00000583378.1
ENST00000536222.1
NFE2L1
nuclear factor, erythroid 2-like 1
chr3_+_50273625 7.70 ENST00000536647.1
GNAI2
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
chr3_+_50192499 7.70 ENST00000413852.1
SEMA3F
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
chr2_+_54684327 7.62 ENST00000389980.3
SPTBN1
spectrin, beta, non-erythrocytic 1
chr3_+_50192537 7.59 ENST00000002829.3
SEMA3F
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
chr3_-_168864427 7.58 ENST00000468789.1
MECOM
MDS1 and EVI1 complex locus
chr2_+_102314161 7.57 ENST00000425019.1
MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chr1_-_111743285 7.55 ENST00000357640.4
DENND2D
DENN/MADD domain containing 2D
chr12_-_8815404 7.55 ENST00000359478.2
ENST00000396549.2
MFAP5
microfibrillar associated protein 5
chr6_+_150464155 7.36 ENST00000361131.4
PPP1R14C
protein phosphatase 1, regulatory (inhibitor) subunit 14C
chr5_-_95297678 7.17 ENST00000237853.4
ELL2
elongation factor, RNA polymerase II, 2
chr8_-_75233563 7.11 ENST00000342232.4
JPH1
junctophilin 1
chr1_+_44398943 7.02 ENST00000372359.5
ENST00000414809.3
ARTN
artemin
chr5_-_95297534 6.96 ENST00000513343.1
ENST00000431061.2
ELL2
elongation factor, RNA polymerase II, 2
chr15_+_78556809 6.92 ENST00000343789.3
ENST00000394852.3
DNAJA4
DnaJ (Hsp40) homolog, subfamily A, member 4
chr9_-_100954910 6.83 ENST00000375077.4
CORO2A
coronin, actin binding protein, 2A
chr11_-_118661588 6.74 ENST00000534980.1
ENST00000526070.2
DDX6
DEAD (Asp-Glu-Ala-Asp) box helicase 6
chr2_+_17721937 6.71 ENST00000451533.1
VSNL1
visinin-like 1
chr3_-_197024965 6.69 ENST00000392382.2
DLG1
discs, large homolog 1 (Drosophila)
chrX_-_153151586 6.69 ENST00000370060.1
ENST00000370055.1
ENST00000420165.1
L1CAM
L1 cell adhesion molecule
chr19_+_18668616 6.64 ENST00000600372.1
KXD1
KxDL motif containing 1
chr8_+_38758845 6.56 ENST00000519640.1
PLEKHA2
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2
chr1_+_44399466 6.55 ENST00000498139.2
ENST00000491846.1
ARTN
artemin
chr12_-_120663792 6.50 ENST00000546532.1
ENST00000548912.1
PXN
paxillin
chr9_-_34048873 6.46 ENST00000449054.1
ENST00000379239.4
ENST00000539807.1
ENST00000379238.1
ENST00000418786.2
ENST00000360802.1
ENST00000412543.1
UBAP2
ubiquitin associated protein 2
chr9_+_112887772 6.44 ENST00000259318.7
AKAP2
A kinase (PRKA) anchor protein 2
chrX_+_56258844 6.34 ENST00000374928.3
KLF8
Kruppel-like factor 8
chr6_-_33547975 6.28 ENST00000442998.2
ENST00000360661.5
BAK1
BCL2-antagonist/killer 1
chr14_-_100841794 6.26 ENST00000556295.1
ENST00000554820.1
WARS
tryptophanyl-tRNA synthetase
chr4_-_185726906 6.23 ENST00000513317.1
ACSL1
acyl-CoA synthetase long-chain family member 1
chr6_-_33548006 6.21 ENST00000374467.3
BAK1
BCL2-antagonist/killer 1
chr7_-_80548493 6.17 ENST00000536800.1
SEMA3C
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr1_-_115212696 6.13 ENST00000393276.3
ENST00000393277.1
DENND2C
DENN/MADD domain containing 2C
chr6_+_7541808 6.12 ENST00000379802.3
DSP
desmoplakin
chr17_-_39553844 6.10 ENST00000251645.2
KRT31
keratin 31
chr12_-_85306562 6.05 ENST00000551612.1
ENST00000450363.3
ENST00000552192.1
SLC6A15
solute carrier family 6 (neutral amino acid transporter), member 15
chr3_+_50211240 6.04 ENST00000420831.1
SEMA3F
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
chr8_-_101962777 6.00 ENST00000395951.3
YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
chr7_+_142982023 5.96 ENST00000359333.3
ENST00000409244.1
ENST00000409541.1
ENST00000410004.1
TMEM139
transmembrane protein 139
chr17_+_72744791 5.94 ENST00000583369.1
ENST00000262613.5
SLC9A3R1
solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
chr1_-_27709816 5.93 ENST00000374030.1
CD164L2
CD164 sialomucin-like 2
chr6_-_38607628 5.86 ENST00000498633.1
BTBD9
BTB (POZ) domain containing 9
chr13_-_74708372 5.79 ENST00000377666.4
KLF12
Kruppel-like factor 12
chr12_-_85306594 5.72 ENST00000266682.5
SLC6A15
solute carrier family 6 (neutral amino acid transporter), member 15
chr1_-_27709793 5.63 ENST00000374027.3
ENST00000374025.3
CD164L2
CD164 sialomucin-like 2
chr12_-_96793142 5.60 ENST00000552262.1
ENST00000551816.1
ENST00000552496.1
CDK17
cyclin-dependent kinase 17
chr1_+_27189631 5.54 ENST00000339276.4
SFN
stratifin
chr12_-_123011476 5.52 ENST00000528279.1
ENST00000344591.4
ENST00000526560.2
RSRC2
arginine/serine-rich coiled-coil 2
chr20_-_62168672 5.44 ENST00000217185.2
PTK6
protein tyrosine kinase 6
chr5_+_95998673 5.40 ENST00000514845.1
CAST
calpastatin
chr2_-_153573887 5.37 ENST00000493468.2
ENST00000545856.1
PRPF40A
PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)
chr3_-_197024394 5.32 ENST00000434148.1
ENST00000412364.2
ENST00000436682.1
ENST00000456699.2
ENST00000392380.2
DLG1
discs, large homolog 1 (Drosophila)
chr12_-_49581152 5.27 ENST00000550811.1
TUBA1A
tubulin, alpha 1a
chr3_-_49449350 5.22 ENST00000454011.2
ENST00000445425.1
ENST00000422781.1
RHOA
ras homolog family member A
chr3_-_168864315 5.19 ENST00000475754.1
ENST00000484519.1
MECOM
MDS1 and EVI1 complex locus
chr15_-_44069513 5.16 ENST00000433927.1
ELL3
elongation factor RNA polymerase II-like 3
chr3_-_105587879 5.02 ENST00000264122.4
ENST00000403724.1
ENST00000405772.1
CBLB
Cbl proto-oncogene B, E3 ubiquitin protein ligase
chr12_-_8815215 4.95 ENST00000544889.1
ENST00000543369.1
MFAP5
microfibrillar associated protein 5
chr6_+_130339710 4.94 ENST00000526087.1
ENST00000533560.1
ENST00000361794.2
L3MBTL3
l(3)mbt-like 3 (Drosophila)
chr1_+_6511651 4.94 ENST00000434576.1
ESPN
espin
chr3_+_10857885 4.93 ENST00000254488.2
ENST00000454147.1
SLC6A11
solute carrier family 6 (neurotransmitter transporter), member 11
chr15_-_64648273 4.86 ENST00000607537.1
ENST00000303052.7
ENST00000303032.6
CSNK1G1
casein kinase 1, gamma 1
chr12_-_8815477 4.85 ENST00000433590.2
MFAP5
microfibrillar associated protein 5
chr5_-_115910091 4.83 ENST00000257414.8
SEMA6A
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
chr17_-_1619568 4.82 ENST00000571595.1
MIR22HG
MIR22 host gene (non-protein coding)
chr2_-_230787879 4.79 ENST00000435716.1
TRIP12
thyroid hormone receptor interactor 12
chr6_+_74405501 4.79 ENST00000437994.2
ENST00000422508.2
CD109
CD109 molecule
chr1_-_6526192 4.76 ENST00000377782.3
ENST00000351959.5
ENST00000356876.3
TNFRSF25
tumor necrosis factor receptor superfamily, member 25
chr15_+_67390920 4.76 ENST00000559092.1
ENST00000560175.1
SMAD3
SMAD family member 3
chr5_-_43412418 4.73 ENST00000537013.1
ENST00000361115.4
CCL28
chemokine (C-C motif) ligand 28
chr6_+_74405804 4.72 ENST00000287097.5
CD109
CD109 molecule
chr3_-_195538728 4.72 ENST00000349607.4
ENST00000346145.4
MUC4
mucin 4, cell surface associated
chr4_+_2845655 4.70 ENST00000511797.1
ENST00000513328.2
ENST00000508277.1
ENST00000503455.2
ADD1
adducin 1 (alpha)
chr3_-_48130314 4.69 ENST00000439356.1
ENST00000395734.3
ENST00000426837.2
MAP4
microtubule-associated protein 4
chr1_-_23670752 4.69 ENST00000302271.6
ENST00000426846.2
ENST00000427764.2
ENST00000606561.1
ENST00000374616.3
HNRNPR
heterogeneous nuclear ribonucleoprotein R
chr12_-_8815299 4.59 ENST00000535336.1
MFAP5
microfibrillar associated protein 5
chr1_+_111682827 4.57 ENST00000357172.4
CEPT1
choline/ethanolamine phosphotransferase 1
chr12_+_69004736 4.56 ENST00000545720.2
RAP1B
RAP1B, member of RAS oncogene family
chr5_+_95998746 4.54 ENST00000508608.1
CAST
calpastatin
chr1_+_33207381 4.50 ENST00000401073.2
KIAA1522
KIAA1522
chr1_-_23670813 4.48 ENST00000374612.1
HNRNPR
heterogeneous nuclear ribonucleoprotein R
chr7_+_17338239 4.46 ENST00000242057.4
AHR
aryl hydrocarbon receptor
chr5_-_115910630 4.40 ENST00000343348.6
SEMA6A
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
chr1_-_185286461 4.38 ENST00000367498.3
IVNS1ABP
influenza virus NS1A binding protein
chr5_+_82767583 4.37 ENST00000512590.2
ENST00000513960.1
ENST00000513984.1
ENST00000502527.2
VCAN
versican
chr17_+_18280976 4.34 ENST00000399134.4
EVPLL
envoplakin-like
chr2_-_222436988 4.32 ENST00000409854.1
ENST00000281821.2
ENST00000392071.4
ENST00000443796.1
EPHA4
EPH receptor A4
chr12_+_56477093 4.27 ENST00000549672.1
ENST00000415288.2
ERBB3
v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3
chr11_-_118789613 4.25 ENST00000532899.1
BCL9L
B-cell CLL/lymphoma 9-like
chr7_-_80548667 4.25 ENST00000265361.3
SEMA3C
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr1_+_33231221 4.19 ENST00000294521.3
KIAA1522
KIAA1522
chr18_-_48723690 4.17 ENST00000406189.3
MEX3C
mex-3 RNA binding family member C
chr4_-_10117949 4.17 ENST00000508079.1
WDR1
WD repeat domain 1
chr5_-_83680603 4.14 ENST00000296591.5
EDIL3
EGF-like repeats and discoidin I-like domains 3
chrX_+_133507389 4.10 ENST00000370800.4
PHF6
PHD finger protein 6
chr4_+_2845547 4.10 ENST00000264758.7
ENST00000446856.1
ENST00000398125.1
ADD1
adducin 1 (alpha)
chr2_-_64371546 4.09 ENST00000358912.4
PELI1
pellino E3 ubiquitin protein ligase 1
chr5_-_142077569 4.09 ENST00000407758.1
ENST00000441680.2
ENST00000419524.2
FGF1
fibroblast growth factor 1 (acidic)
chr1_+_16090914 4.07 ENST00000441801.2
FBLIM1
filamin binding LIM protein 1
chr7_+_73245193 4.07 ENST00000340958.2
CLDN4
claudin 4
chr9_+_110046334 4.06 ENST00000416373.2
RAD23B
RAD23 homolog B (S. cerevisiae)
chr22_-_36357671 4.01 ENST00000408983.2
RBFOX2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr1_+_40505891 3.99 ENST00000372797.3
ENST00000372802.1
ENST00000449311.1
CAP1
CAP, adenylate cyclase-associated protein 1 (yeast)
chr3_-_106959424 3.96 ENST00000607801.1
ENST00000479612.2
ENST00000484698.1
ENST00000477210.2
ENST00000473636.1
LINC00882
long intergenic non-protein coding RNA 882
chr1_+_161195835 3.95 ENST00000545897.1
TOMM40L
translocase of outer mitochondrial membrane 40 homolog (yeast)-like
chr16_-_30597000 3.95 ENST00000470110.1
ENST00000395216.2
ZNF785
zinc finger protein 785
chr6_+_143857949 3.93 ENST00000367584.4
PHACTR2
phosphatase and actin regulator 2
chr19_+_13135731 3.90 ENST00000587260.1
NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr6_-_30654977 3.90 ENST00000399199.3
PPP1R18
protein phosphatase 1, regulatory subunit 18
chr3_-_113464906 3.87 ENST00000477813.1
NAA50
N(alpha)-acetyltransferase 50, NatE catalytic subunit
chr1_-_33168336 3.82 ENST00000373484.3
SYNC
syncoilin, intermediate filament protein
chr4_+_48018781 3.82 ENST00000295461.5
NIPAL1
NIPA-like domain containing 1
chr20_-_20693131 3.80 ENST00000202677.7
RALGAPA2
Ral GTPase activating protein, alpha subunit 2 (catalytic)
chr19_-_10676666 3.80 ENST00000539027.1
ENST00000543682.1
ENST00000361821.5
ENST00000312962.6
KRI1
KRI1 homolog (S. cerevisiae)
chr1_-_23670817 3.79 ENST00000478691.1
HNRNPR
heterogeneous nuclear ribonucleoprotein R
chr17_-_1619491 3.74 ENST00000570416.1
ENST00000575626.1
ENST00000610106.1
ENST00000608198.1
ENST00000609442.1
ENST00000334146.3
ENST00000576489.1
ENST00000608245.1
ENST00000609398.1
ENST00000608913.1
ENST00000574016.1
ENST00000571091.1
ENST00000573127.1
ENST00000609990.1
ENST00000576749.1
MIR22HG
MIR22 host gene (non-protein coding)
chr3_-_105588231 3.72 ENST00000545639.1
ENST00000394027.3
ENST00000438603.1
ENST00000447441.1
ENST00000443752.1
CBLB
Cbl proto-oncogene B, E3 ubiquitin protein ligase
chr1_+_11072738 3.72 ENST00000439080.2
TARDBP
TAR DNA binding protein
chr1_-_205744574 3.67 ENST00000367139.3
ENST00000235932.4
ENST00000437324.2
ENST00000414729.1
RAB7L1
RAB7, member RAS oncogene family-like 1
chr2_-_85637459 3.66 ENST00000409921.1
CAPG
capping protein (actin filament), gelsolin-like
chr1_-_113249734 3.61 ENST00000484054.3
ENST00000369636.2
ENST00000369637.1
ENST00000285735.2
ENST00000369638.2
RHOC
ras homolog family member C
chr17_-_56065484 3.60 ENST00000581208.1
VEZF1
vascular endothelial zinc finger 1
chr1_-_205744205 3.58 ENST00000446390.2
RAB7L1
RAB7, member RAS oncogene family-like 1
chr7_+_22766766 3.57 ENST00000426291.1
ENST00000401651.1
ENST00000258743.5
ENST00000420258.2
ENST00000407492.1
ENST00000401630.3
ENST00000406575.1
IL6
interleukin 6 (interferon, beta 2)
chr6_-_138428613 3.55 ENST00000421351.3
PERP
PERP, TP53 apoptosis effector
chr1_-_113249678 3.54 ENST00000369633.2
ENST00000425265.2
ENST00000369632.2
ENST00000436685.2
RHOC
ras homolog family member C
chr1_-_94147385 3.53 ENST00000260502.6
BCAR3
breast cancer anti-estrogen resistance 3
chr3_-_71114066 3.53 ENST00000485326.2
FOXP1
forkhead box P1
chr2_+_201171372 3.52 ENST00000409140.3
SPATS2L
spermatogenesis associated, serine-rich 2-like
chr19_-_36019123 3.52 ENST00000588674.1
ENST00000452271.2
ENST00000518157.1
SBSN
suprabasin
chr11_+_71903169 3.51 ENST00000393676.3
FOLR1
folate receptor 1 (adult)
chr20_-_50722183 3.50 ENST00000371523.4
ZFP64
ZFP64 zinc finger protein
chr1_-_6526167 3.49 ENST00000351748.3
ENST00000348333.3
TNFRSF25
tumor necrosis factor receptor superfamily, member 25
chr2_-_61765732 3.47 ENST00000443240.1
ENST00000436018.1
XPO1
exportin 1 (CRM1 homolog, yeast)
chr12_-_54778471 3.45 ENST00000550120.1
ENST00000394313.2
ENST00000547210.1
ZNF385A
zinc finger protein 385A
chr17_-_7382834 3.42 ENST00000380599.4
ZBTB4
zinc finger and BTB domain containing 4

Network of associatons between targets according to the STRING database.

First level regulatory network of KLF1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
4.2 12.5 GO:0048597 B cell negative selection(GO:0002352) post-embryonic camera-type eye morphogenesis(GO:0048597)
4.0 12.1 GO:0048627 myoblast development(GO:0048627)
3.6 21.6 GO:0097021 lymphocyte migration into lymphoid organs(GO:0097021)
3.3 20.1 GO:1902045 negative regulation of Fas signaling pathway(GO:1902045)
2.6 7.8 GO:1990108 protein linear deubiquitination(GO:1990108)
2.6 20.5 GO:0018242 protein O-linked glycosylation via serine(GO:0018242)
2.4 14.5 GO:1902766 skeletal muscle satellite cell migration(GO:1902766)
2.2 30.5 GO:0035290 trunk segmentation(GO:0035290) trunk neural crest cell migration(GO:0036484) ventral trunk neural crest cell migration(GO:0036486) neural crest cell migration involved in autonomic nervous system development(GO:1901166)
2.1 10.7 GO:1903284 negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) positive regulation of peroxidase activity(GO:2000470)
2.0 5.9 GO:0035508 positive regulation of myosin-light-chain-phosphatase activity(GO:0035508)
1.8 7.0 GO:0097156 fasciculation of motor neuron axon(GO:0097156)
1.7 8.7 GO:0018125 peptidyl-cysteine methylation(GO:0018125)
1.7 10.4 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
1.7 27.0 GO:0010668 ectodermal cell differentiation(GO:0010668)
1.7 6.7 GO:0019074 viral genome packaging(GO:0019072) viral RNA genome packaging(GO:0019074)
1.6 29.6 GO:0043587 tongue morphogenesis(GO:0043587)
1.6 9.6 GO:0006436 tryptophanyl-tRNA aminoacylation(GO:0006436)
1.6 10.9 GO:0072675 multinuclear osteoclast differentiation(GO:0072674) osteoclast fusion(GO:0072675)
1.6 9.3 GO:0010760 negative regulation of macrophage chemotaxis(GO:0010760)
1.5 17.7 GO:0086073 bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073)
1.5 4.4 GO:0001300 chronological cell aging(GO:0001300)
1.4 62.7 GO:0006783 heme biosynthetic process(GO:0006783)
1.4 9.9 GO:1902164 mRNA localization resulting in posttranscriptional regulation of gene expression(GO:0010609) regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902162) positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902164)
1.4 9.5 GO:1903575 cornified envelope assembly(GO:1903575)
1.3 7.6 GO:1900042 positive regulation of interleukin-2 secretion(GO:1900042)
1.2 12.0 GO:1903764 regulation of potassium ion export across plasma membrane(GO:1903764)
1.2 21.3 GO:0090168 Golgi reassembly(GO:0090168)
1.2 11.8 GO:0015820 leucine transport(GO:0015820)
1.2 3.5 GO:0050904 diapedesis(GO:0050904)
1.2 3.5 GO:0061713 neural crest cell migration involved in heart formation(GO:0003147) anterior neural tube closure(GO:0061713)
1.2 15.1 GO:0042048 olfactory behavior(GO:0042048)
1.1 5.5 GO:0010481 epidermal cell division(GO:0010481) regulation of epidermal cell division(GO:0010482)
1.1 18.5 GO:0006600 creatine metabolic process(GO:0006600)
1.0 4.2 GO:0016334 morphogenesis of follicular epithelium(GO:0016333) establishment or maintenance of polarity of follicular epithelium(GO:0016334) establishment of planar polarity of follicular epithelium(GO:0042247)
1.0 16.1 GO:0035634 response to stilbenoid(GO:0035634)
1.0 10.0 GO:0071847 TNFSF11-mediated signaling pathway(GO:0071847)
1.0 5.9 GO:0051683 establishment of Golgi localization(GO:0051683)
1.0 3.0 GO:0048203 vesicle targeting, trans-Golgi to endosome(GO:0048203)
1.0 17.5 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.9 3.6 GO:0002384 hepatic immune response(GO:0002384) response to prolactin(GO:1990637)
0.9 27.3 GO:0010592 positive regulation of lamellipodium assembly(GO:0010592)
0.9 6.2 GO:0072553 terminal button organization(GO:0072553)
0.8 7.6 GO:1900242 regulation of synaptic vesicle endocytosis(GO:1900242)
0.8 9.3 GO:1903142 positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142)
0.8 7.6 GO:0070601 centromeric sister chromatid cohesion(GO:0070601)
0.8 13.6 GO:2000675 negative regulation of type B pancreatic cell apoptotic process(GO:2000675)
0.8 10.6 GO:1900086 positive regulation of peptidyl-tyrosine autophosphorylation(GO:1900086)
0.7 3.7 GO:1903237 negative regulation of leukocyte tethering or rolling(GO:1903237)
0.7 3.0 GO:0097010 eukaryotic translation initiation factor 4F complex assembly(GO:0097010)
0.7 3.6 GO:0002296 T-helper 1 cell lineage commitment(GO:0002296)
0.7 0.7 GO:1904666 regulation of ubiquitin protein ligase activity(GO:1904666) positive regulation of ubiquitin protein ligase activity(GO:1904668)
0.7 4.8 GO:0061767 negative regulation of lung blood pressure(GO:0061767)
0.7 4.7 GO:0051012 microtubule sliding(GO:0051012)
0.7 38.0 GO:2000649 regulation of sodium ion transmembrane transporter activity(GO:2000649)
0.7 10.6 GO:0015816 glycine transport(GO:0015816)
0.7 2.0 GO:2000681 negative regulation of rubidium ion transport(GO:2000681) negative regulation of rubidium ion transmembrane transporter activity(GO:2000687)
0.6 3.1 GO:0090649 rRNA transport(GO:0051029) response to oxygen-glucose deprivation(GO:0090649) cellular response to oxygen-glucose deprivation(GO:0090650)
0.6 2.5 GO:0050916 sensory perception of sweet taste(GO:0050916)
0.6 3.5 GO:0016476 regulation of embryonic cell shape(GO:0016476)
0.6 3.5 GO:0072619 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
0.6 4.1 GO:0008063 Toll signaling pathway(GO:0008063)
0.6 9.3 GO:0015074 DNA integration(GO:0015074)
0.6 2.9 GO:0032185 septin cytoskeleton organization(GO:0032185)
0.6 3.3 GO:0033489 cholesterol biosynthetic process via desmosterol(GO:0033489) cholesterol biosynthetic process via lathosterol(GO:0033490)
0.5 6.0 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.5 3.2 GO:0006438 valyl-tRNA aminoacylation(GO:0006438)
0.5 18.3 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.5 38.9 GO:0010765 positive regulation of sodium ion transport(GO:0010765)
0.5 4.2 GO:0003415 chondrocyte hypertrophy(GO:0003415)
0.5 6.2 GO:0044539 long-chain fatty acid import(GO:0044539)
0.5 1.6 GO:1990654 sebum secreting cell proliferation(GO:1990654)
0.5 4.1 GO:0033623 regulation of integrin activation(GO:0033623)
0.5 2.0 GO:0035521 monoubiquitinated histone deubiquitination(GO:0035521) monoubiquitinated histone H2A deubiquitination(GO:0035522)
0.5 4.0 GO:0021592 fourth ventricle development(GO:0021592)
0.5 2.5 GO:2001045 negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.5 26.0 GO:0060216 definitive hemopoiesis(GO:0060216)
0.5 1.5 GO:0060988 lipid tube assembly(GO:0060988)
0.5 2.9 GO:0036353 histone H2A-K119 monoubiquitination(GO:0036353)
0.5 15.8 GO:0031581 hemidesmosome assembly(GO:0031581)
0.5 4.8 GO:0033183 negative regulation of histone ubiquitination(GO:0033183) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315)
0.5 4.3 GO:0099590 neurotransmitter receptor internalization(GO:0099590)
0.5 2.8 GO:0008626 granzyme-mediated apoptotic signaling pathway(GO:0008626)
0.5 12.1 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.5 1.8 GO:2000370 positive regulation of clathrin-mediated endocytosis(GO:2000370)
0.5 4.1 GO:1901509 regulation of endothelial tube morphogenesis(GO:1901509)
0.4 1.8 GO:0010637 negative regulation of mitochondrial fusion(GO:0010637)
0.4 9.3 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.4 2.2 GO:1901097 negative regulation of autophagosome maturation(GO:1901097)
0.4 1.7 GO:1905224 clathrin-coated pit assembly(GO:1905224)
0.4 8.1 GO:0005981 regulation of glycogen catabolic process(GO:0005981)
0.4 1.6 GO:0033206 meiotic chromosome movement towards spindle pole(GO:0016344) meiotic cytokinesis(GO:0033206)
0.4 8.7 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.4 2.4 GO:0035026 leading edge cell differentiation(GO:0035026)
0.4 8.6 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
0.4 2.7 GO:0098914 membrane repolarization during atrial cardiac muscle cell action potential(GO:0098914)
0.4 3.1 GO:0032808 lacrimal gland development(GO:0032808)
0.4 4.6 GO:0006657 CDP-choline pathway(GO:0006657)
0.4 3.8 GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000447)
0.4 2.6 GO:0006041 glucosamine metabolic process(GO:0006041)
0.4 2.2 GO:0002317 plasma cell differentiation(GO:0002317)
0.4 1.1 GO:2000656 regulation of apolipoprotein binding(GO:2000656) negative regulation of apolipoprotein binding(GO:2000657)
0.4 8.9 GO:0009950 dorsal/ventral axis specification(GO:0009950)
0.3 3.5 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
0.3 3.5 GO:0000055 ribosomal large subunit export from nucleus(GO:0000055) ribosomal small subunit export from nucleus(GO:0000056)
0.3 11.2 GO:0030033 microvillus assembly(GO:0030033)
0.3 1.7 GO:0070829 response to vitamin B2(GO:0033274) heterochromatin maintenance(GO:0070829)
0.3 4.3 GO:0030091 protein repair(GO:0030091)
0.3 4.9 GO:0030046 parallel actin filament bundle assembly(GO:0030046)
0.3 5.0 GO:0015693 magnesium ion transport(GO:0015693)
0.3 2.8 GO:0018879 biphenyl metabolic process(GO:0018879)
0.3 3.9 GO:0071763 nuclear membrane organization(GO:0071763)
0.3 6.9 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
0.3 3.0 GO:0002934 desmosome organization(GO:0002934)
0.3 1.8 GO:0044805 late nucleophagy(GO:0044805)
0.3 4.4 GO:0043249 erythrocyte maturation(GO:0043249)
0.3 2.0 GO:0010025 wax biosynthetic process(GO:0010025) wax metabolic process(GO:0010166)
0.3 0.3 GO:0021897 forebrain astrocyte differentiation(GO:0021896) forebrain astrocyte development(GO:0021897)
0.3 14.6 GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0035774)
0.3 10.0 GO:0061157 mRNA destabilization(GO:0061157)
0.3 3.1 GO:0031053 primary miRNA processing(GO:0031053)
0.2 8.3 GO:0015695 organic cation transport(GO:0015695)
0.2 6.8 GO:0030208 dermatan sulfate biosynthetic process(GO:0030208)
0.2 5.4 GO:0060575 intestinal epithelial cell differentiation(GO:0060575)
0.2 0.5 GO:0090149 mitochondrial membrane fission(GO:0090149)
0.2 5.1 GO:0015812 gamma-aminobutyric acid transport(GO:0015812)
0.2 5.3 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.2 2.7 GO:0033182 regulation of histone ubiquitination(GO:0033182)
0.2 4.4 GO:0060340 positive regulation of type I interferon-mediated signaling pathway(GO:0060340)
0.2 2.0 GO:0007288 sperm axoneme assembly(GO:0007288)
0.2 0.7 GO:0090238 negative regulation of icosanoid secretion(GO:0032304) regulation of arachidonic acid secretion(GO:0090237) positive regulation of arachidonic acid secretion(GO:0090238)
0.2 8.6 GO:0000717 nucleotide-excision repair, DNA duplex unwinding(GO:0000717)
0.2 3.5 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.2 5.2 GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:1902166)
0.2 1.4 GO:0055005 ventricular cardiac myofibril assembly(GO:0055005)
0.2 7.4 GO:0071425 hematopoietic stem cell proliferation(GO:0071425)
0.2 4.3 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
0.2 3.1 GO:2000291 regulation of myoblast proliferation(GO:2000291)
0.2 2.3 GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter(GO:0032968)
0.2 3.2 GO:0031937 positive regulation of chromatin silencing(GO:0031937)
0.2 4.8 GO:1904778 regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778)
0.2 1.8 GO:0051005 negative regulation of lipoprotein lipase activity(GO:0051005)
0.2 0.4 GO:0071315 cellular response to morphine(GO:0071315) cellular response to isoquinoline alkaloid(GO:0071317)
0.2 4.9 GO:0019373 epoxygenase P450 pathway(GO:0019373)
0.2 1.9 GO:0001714 endodermal cell fate specification(GO:0001714)
0.2 12.9 GO:0001954 positive regulation of cell-matrix adhesion(GO:0001954)
0.2 7.1 GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity(GO:0060314)
0.2 4.7 GO:0003323 type B pancreatic cell development(GO:0003323)
0.2 2.3 GO:0072718 response to cisplatin(GO:0072718)
0.2 2.1 GO:0035019 somatic stem cell population maintenance(GO:0035019)
0.2 0.5 GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway(GO:0007198)
0.2 9.1 GO:0006383 transcription from RNA polymerase III promoter(GO:0006383)
0.2 1.1 GO:1904491 protein localization to ciliary transition zone(GO:1904491)
0.2 14.9 GO:0009301 snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.2 1.7 GO:0042492 gamma-delta T cell differentiation(GO:0042492)
0.1 0.9 GO:0093001 glycolysis from storage polysaccharide through glucose-1-phosphate(GO:0093001)
0.1 7.1 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)
0.1 2.2 GO:1904896 ESCRT complex disassembly(GO:1904896) ESCRT III complex disassembly(GO:1904903)
0.1 0.8 GO:0046600 negative regulation of centriole replication(GO:0046600)
0.1 6.5 GO:0060396 growth hormone receptor signaling pathway(GO:0060396) cellular response to growth hormone stimulus(GO:0071378)
0.1 19.0 GO:0070268 cornification(GO:0070268)
0.1 7.0 GO:1904837 beta-catenin-TCF complex assembly(GO:1904837)
0.1 1.9 GO:0033235 positive regulation of protein sumoylation(GO:0033235)
0.1 1.9 GO:0032287 peripheral nervous system myelin maintenance(GO:0032287)
0.1 1.1 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.1 2.7 GO:0031639 plasminogen activation(GO:0031639)
0.1 0.4 GO:1902525 regulation of protein monoubiquitination(GO:1902525)
0.1 1.0 GO:1900004 negative regulation of serine-type endopeptidase activity(GO:1900004) negative regulation of serine-type peptidase activity(GO:1902572)
0.1 1.4 GO:0006621 protein retention in ER lumen(GO:0006621)
0.1 0.4 GO:1901165 positive regulation of trophoblast cell migration(GO:1901165)
0.1 1.5 GO:0043985 histone H4-R3 methylation(GO:0043985)
0.1 3.8 GO:0010628 positive regulation of gene expression(GO:0010628)
0.1 1.2 GO:2000623 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.1 5.3 GO:0035666 TRIF-dependent toll-like receptor signaling pathway(GO:0035666)
0.1 1.0 GO:0006552 leucine catabolic process(GO:0006552)
0.1 3.4 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.1 3.8 GO:0002576 platelet degranulation(GO:0002576)
0.1 1.1 GO:0010571 positive regulation of nuclear cell cycle DNA replication(GO:0010571)
0.1 0.3 GO:0045553 TRAIL biosynthetic process(GO:0045553) regulation of TRAIL biosynthetic process(GO:0045554) positive regulation of TRAIL biosynthetic process(GO:0045556)
0.1 2.2 GO:0006490 oligosaccharide-lipid intermediate biosynthetic process(GO:0006490)
0.1 1.7 GO:0035563 positive regulation of chromatin binding(GO:0035563)
0.1 1.4 GO:0061635 regulation of protein complex stability(GO:0061635)
0.1 3.3 GO:0022400 regulation of rhodopsin mediated signaling pathway(GO:0022400)
0.1 3.2 GO:0046710 GDP metabolic process(GO:0046710)
0.1 3.0 GO:0000281 mitotic cytokinesis(GO:0000281)
0.1 2.1 GO:0045773 positive regulation of axon extension(GO:0045773)
0.1 2.0 GO:0010800 positive regulation of peptidyl-threonine phosphorylation(GO:0010800)
0.1 7.1 GO:0032465 regulation of cytokinesis(GO:0032465)
0.1 1.5 GO:0043562 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.1 7.9 GO:0032418 lysosome localization(GO:0032418)
0.1 1.1 GO:0035269 protein O-linked mannosylation(GO:0035269)
0.1 0.4 GO:0021707 cerebellar granular layer morphogenesis(GO:0021683) cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.1 0.2 GO:0035408 histone H3-T6 phosphorylation(GO:0035408)
0.1 0.4 GO:0090038 negative regulation of protein kinase C signaling(GO:0090038)
0.1 2.8 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.1 3.9 GO:0001885 endothelial cell development(GO:0001885)
0.1 1.3 GO:0071427 mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427)
0.1 2.5 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.1 0.5 GO:0038165 oncostatin-M-mediated signaling pathway(GO:0038165)
0.1 1.2 GO:0006474 N-terminal protein amino acid acetylation(GO:0006474)
0.1 3.1 GO:0006099 tricarboxylic acid cycle(GO:0006099)
0.1 2.7 GO:0007190 activation of adenylate cyclase activity(GO:0007190)
0.1 3.8 GO:0003009 skeletal muscle contraction(GO:0003009)
0.1 4.9 GO:0008360 regulation of cell shape(GO:0008360)
0.1 0.3 GO:0048146 positive regulation of fibroblast proliferation(GO:0048146)
0.1 0.2 GO:0072254 metanephric mesangial cell differentiation(GO:0072209) metanephric glomerular mesangial cell differentiation(GO:0072254) metanephric glomerular mesangial cell development(GO:0072255) reversible differentiation(GO:0090677) cell dedifferentiation involved in phenotypic switching(GO:0090678) positive regulation of phenotypic switching(GO:1900241) regulation of vascular smooth muscle cell dedifferentiation(GO:1905174) positive regulation of vascular smooth muscle cell dedifferentiation(GO:1905176) vascular smooth muscle cell dedifferentiation(GO:1990936)
0.1 4.5 GO:0030888 regulation of B cell proliferation(GO:0030888)
0.1 1.8 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.1 2.0 GO:0000301 retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.0 0.6 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 2.0 GO:0034035 purine ribonucleoside bisphosphate metabolic process(GO:0034035) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427)
0.0 0.6 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.0 0.8 GO:0006069 ethanol oxidation(GO:0006069)
0.0 1.8 GO:1903959 regulation of anion transmembrane transport(GO:1903959)
0.0 1.5 GO:0045494 photoreceptor cell maintenance(GO:0045494)
0.0 2.0 GO:0050435 beta-amyloid metabolic process(GO:0050435)
0.0 5.4 GO:0016032 viral process(GO:0016032) multi-organism cellular process(GO:0044764)
0.0 0.4 GO:0032876 regulation of DNA endoreduplication(GO:0032875) negative regulation of DNA endoreduplication(GO:0032876) DNA endoreduplication(GO:0042023)
0.0 0.2 GO:0061086 negative regulation of histone H3-K27 methylation(GO:0061086)
0.0 2.5 GO:0006305 DNA alkylation(GO:0006305) DNA methylation(GO:0006306)
0.0 2.8 GO:0006939 smooth muscle contraction(GO:0006939)
0.0 0.8 GO:0021591 ventricular system development(GO:0021591)
0.0 1.9 GO:0005977 glycogen metabolic process(GO:0005977)
0.0 0.5 GO:0031532 actin cytoskeleton reorganization(GO:0031532)
0.0 0.7 GO:0070932 histone H3 deacetylation(GO:0070932)
0.0 0.2 GO:0019368 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 0.1 GO:1904154 positive regulation of retrograde protein transport, ER to cytosol(GO:1904154)
0.0 0.6 GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123)
0.0 0.4 GO:0061049 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0 1.2 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.0 0.6 GO:0071377 cellular response to glucagon stimulus(GO:0071377)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
6.7 27.0 GO:0034676 integrin alpha6-beta4 complex(GO:0034676)
1.5 16.1 GO:0005610 laminin-5 complex(GO:0005610)
1.5 4.4 GO:0072563 endothelial microparticle(GO:0072563)
1.5 8.7 GO:0070381 endosome to plasma membrane transport vesicle(GO:0070381)
1.4 7.0 GO:0071942 XPC complex(GO:0071942)
1.4 25.1 GO:0031209 SCAR complex(GO:0031209)
1.0 7.6 GO:0032437 cuticular plate(GO:0032437)
0.9 12.5 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.9 2.7 GO:0031372 UBC13-MMS2 complex(GO:0031372)
0.9 10.6 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.8 21.9 GO:0001527 microfibril(GO:0001527) fibril(GO:0043205)
0.8 3.4 GO:0071665 gamma-catenin-TCF7L2 complex(GO:0071665)
0.8 4.2 GO:0042643 actomyosin, actin portion(GO:0042643)
0.8 14.0 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.8 4.1 GO:0034753 nuclear aryl hydrocarbon receptor complex(GO:0034753)
0.8 2.4 GO:0036195 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.8 6.2 GO:0031415 NatA complex(GO:0031415)
0.8 12.0 GO:0097025 lateral loop(GO:0043219) MPP7-DLG1-LIN7 complex(GO:0097025)
0.7 3.6 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.7 29.7 GO:0030057 desmosome(GO:0030057)
0.7 3.5 GO:0034669 integrin alpha4-beta7 complex(GO:0034669)
0.7 3.5 GO:0030906 retromer, cargo-selective complex(GO:0030906)
0.7 4.0 GO:0097513 myosin II filament(GO:0097513)
0.7 3.9 GO:0005726 perichromatin fibrils(GO:0005726)
0.6 10.2 GO:0032426 stereocilium tip(GO:0032426)
0.6 3.1 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.6 6.0 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
0.6 7.1 GO:0030314 junctional membrane complex(GO:0030314)
0.6 24.1 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.6 15.1 GO:0005922 connexon complex(GO:0005922)
0.5 7.9 GO:0030478 actin cap(GO:0030478)
0.5 10.3 GO:0097227 sperm annulus(GO:0097227)
0.5 18.3 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.5 38.0 GO:0045095 keratin filament(GO:0045095)
0.5 5.3 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.4 4.8 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.4 43.8 GO:0034707 chloride channel complex(GO:0034707)
0.4 13.7 GO:0044295 axonal growth cone(GO:0044295)
0.4 6.8 GO:0008290 F-actin capping protein complex(GO:0008290)
0.4 20.5 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.3 10.5 GO:0031083 BLOC-1 complex(GO:0031083)
0.3 7.1 GO:0071004 U2-type prespliceosome(GO:0071004)
0.3 2.4 GO:0035976 AP1 complex(GO:0035976)
0.2 17.5 GO:0008023 transcription elongation factor complex(GO:0008023)
0.2 1.2 GO:0031417 NatC complex(GO:0031417)
0.2 4.4 GO:0032433 filopodium tip(GO:0032433)
0.2 9.5 GO:0043034 costamere(GO:0043034)
0.2 5.0 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.2 1.0 GO:0002169 3-methylcrotonyl-CoA carboxylase complex, mitochondrial(GO:0002169) methylcrotonoyl-CoA carboxylase complex(GO:1905202)
0.2 3.8 GO:0005861 troponin complex(GO:0005861)
0.2 14.5 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.2 3.1 GO:0071141 SMAD protein complex(GO:0071141)
0.2 0.9 GO:0097427 microtubule bundle(GO:0097427)
0.1 20.1 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.1 5.8 GO:0090545 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1 2.5 GO:0016342 catenin complex(GO:0016342)
0.1 3.3 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.1 12.7 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 19.1 GO:0005796 Golgi lumen(GO:0005796)
0.1 12.8 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 21.3 GO:0035579 specific granule membrane(GO:0035579)
0.1 3.0 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.1 8.8 GO:0016235 aggresome(GO:0016235)
0.1 13.3 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 3.0 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.1 0.9 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.1 14.2 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.1 2.4 GO:0033270 paranode region of axon(GO:0033270)
0.1 3.8 GO:0030686 90S preribosome(GO:0030686)
0.1 6.3 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 0.6 GO:0034991 nuclear meiotic cohesin complex(GO:0034991)
0.1 8.0 GO:0035577 azurophil granule membrane(GO:0035577)
0.1 3.9 GO:0031985 Golgi cisterna(GO:0031985)
0.1 14.3 GO:0031225 anchored component of membrane(GO:0031225)
0.1 4.7 GO:0099738 cell cortex region(GO:0099738)
0.1 16.4 GO:0072562 blood microparticle(GO:0072562)
0.1 2.9 GO:0031258 lamellipodium membrane(GO:0031258)
0.1 1.8 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.1 1.6 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.1 1.5 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.1 0.6 GO:0030905 retromer, tubulation complex(GO:0030905)
0.1 2.5 GO:0005640 nuclear outer membrane(GO:0005640)
0.1 1.1 GO:0031143 pseudopodium(GO:0031143)
0.0 1.5 GO:0000421 autophagosome membrane(GO:0000421)
0.0 0.2 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.0 5.1 GO:0097517 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 5.1 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 1.0 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.0 4.7 GO:0005930 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.0 4.8 GO:0035578 azurophil granule lumen(GO:0035578)
0.0 6.2 GO:0005923 bicellular tight junction(GO:0005923)
0.0 0.5 GO:0042641 actomyosin(GO:0042641)
0.0 1.9 GO:0055037 recycling endosome(GO:0055037)
0.0 0.7 GO:0000124 SAGA complex(GO:0000124)
0.0 2.0 GO:0005720 nuclear heterochromatin(GO:0005720)
0.0 3.4 GO:0035097 histone methyltransferase complex(GO:0035097)
0.0 3.9 GO:0005681 spliceosomal complex(GO:0005681)
0.0 1.6 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.0 0.9 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 4.7 GO:0016605 PML body(GO:0016605)
0.0 9.3 GO:0000790 nuclear chromatin(GO:0000790)
0.0 1.5 GO:0001917 photoreceptor inner segment(GO:0001917)
0.0 0.4 GO:0046930 pore complex(GO:0046930)
0.0 0.4 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 1.5 GO:0030315 T-tubule(GO:0030315)
0.0 2.4 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 1.0 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 5.5 GO:0030016 myofibril(GO:0030016)
0.0 1.4 GO:0005771 multivesicular body(GO:0005771)
0.0 41.9 GO:0005615 extracellular space(GO:0005615)
0.0 0.6 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 32.2 GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network(GO:0042175)
0.0 1.8 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.0 0.8 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 2.2 GO:0005770 late endosome(GO:0005770)
0.0 0.8 GO:0016592 mediator complex(GO:0016592)
0.0 2.1 GO:0019897 extrinsic component of plasma membrane(GO:0019897)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
3.9 11.8 GO:0005298 proline:sodium symporter activity(GO:0005298)
2.6 26.1 GO:0004111 creatine kinase activity(GO:0004111)
2.5 12.4 GO:0030197 extracellular matrix constituent, lubricant activity(GO:0030197)
2.2 31.3 GO:0038132 neuregulin binding(GO:0038132)
2.1 10.7 GO:0060961 phospholipase D inhibitor activity(GO:0060961)
1.6 8.1 GO:0050115 myosin-light-chain-phosphatase activity(GO:0050115)
1.6 9.6 GO:0004830 tryptophan-tRNA ligase activity(GO:0004830)
1.5 17.7 GO:0086083 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083)
1.4 5.5 GO:0008426 protein kinase C inhibitor activity(GO:0008426)
1.3 30.5 GO:0045499 chemorepellent activity(GO:0045499)
1.2 13.6 GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
1.2 17.5 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
1.1 4.6 GO:0004142 diacylglycerol cholinephosphotransferase activity(GO:0004142) ethanolaminephosphotransferase activity(GO:0004307)
1.1 4.5 GO:0004874 aryl hydrocarbon receptor activity(GO:0004874)
1.0 3.1 GO:0004108 citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440)
1.0 71.1 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
1.0 81.9 GO:0017080 sodium channel regulator activity(GO:0017080)
0.9 12.0 GO:0097016 L27 domain binding(GO:0097016)
0.9 3.5 GO:0061714 folic acid receptor activity(GO:0061714)
0.8 23.5 GO:0044548 S100 protein binding(GO:0044548)
0.8 4.7 GO:0051032 nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
0.7 5.2 GO:0051021 GDP-dissociation inhibitor binding(GO:0051021) Rho GDP-dissociation inhibitor binding(GO:0051022)
0.7 3.0 GO:0034057 RNA strand-exchange activity(GO:0034057)
0.7 2.2 GO:0030395 lactose binding(GO:0030395)
0.7 10.2 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.7 4.8 GO:0031962 mineralocorticoid receptor binding(GO:0031962)
0.6 4.5 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.6 8.3 GO:0019534 toxin transporter activity(GO:0019534)
0.6 11.2 GO:0030215 semaphorin receptor binding(GO:0030215)
0.6 2.5 GO:0000822 inositol hexakisphosphate binding(GO:0000822) inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.6 4.9 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332) gamma-aminobutyric acid transmembrane transporter activity(GO:0015185)
0.6 7.7 GO:0042731 PH domain binding(GO:0042731)
0.6 12.5 GO:0051400 BH domain binding(GO:0051400)
0.6 7.3 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.6 2.2 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.5 4.4 GO:0005534 galactose binding(GO:0005534)
0.5 2.7 GO:0086089 voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization(GO:0086089)
0.5 3.2 GO:0004832 valine-tRNA ligase activity(GO:0004832)
0.5 7.4 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.5 2.8 GO:0050815 phosphoserine binding(GO:0050815)
0.5 20.1 GO:0005123 death receptor binding(GO:0005123)
0.5 11.3 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.4 3.5 GO:0019960 C-X3-C chemokine binding(GO:0019960)
0.4 5.7 GO:0015288 porin activity(GO:0015288)
0.4 17.4 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.4 7.4 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.4 5.9 GO:0045159 myosin II binding(GO:0045159)
0.4 2.7 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.4 2.6 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.4 1.8 GO:0010465 nerve growth factor receptor activity(GO:0010465)
0.4 1.1 GO:0070984 SET domain binding(GO:0070984)
0.4 3.6 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.3 2.3 GO:0031748 D1 dopamine receptor binding(GO:0031748)
0.3 3.0 GO:0019870 potassium channel inhibitor activity(GO:0019870)
0.3 2.0 GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019)
0.3 1.7 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
0.3 7.9 GO:0005523 tropomyosin binding(GO:0005523)
0.3 13.2 GO:0004385 guanylate kinase activity(GO:0004385)
0.3 0.8 GO:0097158 pre-mRNA intronic pyrimidine-rich binding(GO:0097158)
0.3 3.8 GO:0031014 troponin T binding(GO:0031014)
0.3 10.0 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.3 3.2 GO:1990226 histone methyltransferase binding(GO:1990226)
0.3 3.1 GO:0032794 GTPase activating protein binding(GO:0032794)
0.2 2.0 GO:0071532 ankyrin repeat binding(GO:0071532)
0.2 9.3 GO:0017166 vinculin binding(GO:0017166)
0.2 3.1 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.2 6.2 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.2 2.0 GO:0070740 tubulin-glutamic acid ligase activity(GO:0070740)
0.2 5.0 GO:0070330 aromatase activity(GO:0070330)
0.2 16.9 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.2 4.0 GO:0008179 adenylate cyclase binding(GO:0008179)
0.2 8.5 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.2 7.9 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.2 2.5 GO:0008526 phosphatidylcholine transporter activity(GO:0008525) phosphatidylinositol transporter activity(GO:0008526)
0.2 7.4 GO:0030506 ankyrin binding(GO:0030506)
0.2 1.0 GO:0004485 methylcrotonoyl-CoA carboxylase activity(GO:0004485)
0.2 9.3 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.2 4.1 GO:0031005 filamin binding(GO:0031005)
0.2 41.6 GO:0017124 SH3 domain binding(GO:0017124)
0.2 12.7 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.2 5.8 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.1 4.7 GO:0031489 myosin V binding(GO:0031489)
0.1 2.3 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.1 16.2 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 3.1 GO:0051721 protein phosphatase 2A binding(GO:0051721)
0.1 1.7 GO:0003964 telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)
0.1 38.0 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 0.6 GO:1990460 leptin receptor binding(GO:1990460)
0.1 11.4 GO:0008307 structural constituent of muscle(GO:0008307)
0.1 2.8 GO:0017049 GTP-Rho binding(GO:0017049)
0.1 2.5 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.1 5.2 GO:0097110 scaffold protein binding(GO:0097110)
0.1 3.0 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.1 3.4 GO:0008327 methyl-CpG binding(GO:0008327)
0.1 4.8 GO:0046966 thyroid hormone receptor binding(GO:0046966)
0.1 7.2 GO:0019003 GDP binding(GO:0019003)
0.1 2.4 GO:0071837 HMG box domain binding(GO:0071837)
0.1 5.4 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.1 9.9 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.1 0.8 GO:0004024 alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
0.1 0.7 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.1 3.3 GO:0030553 cGMP binding(GO:0030553)
0.1 0.9 GO:0003872 6-phosphofructokinase activity(GO:0003872)
0.1 7.0 GO:0031593 polyubiquitin binding(GO:0031593)
0.1 3.3 GO:0042605 peptide antigen binding(GO:0042605)
0.1 0.4 GO:0034711 inhibin binding(GO:0034711)
0.1 3.7 GO:0008009 chemokine activity(GO:0008009)
0.1 16.7 GO:0044325 ion channel binding(GO:0044325)
0.1 20.8 GO:0051015 actin filament binding(GO:0051015)
0.1 1.2 GO:0030276 clathrin binding(GO:0030276)
0.1 5.0 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899)
0.1 9.3 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 5.1 GO:0005048 signal sequence binding(GO:0005048)
0.1 7.2 GO:0004407 histone deacetylase activity(GO:0004407)
0.1 2.0 GO:0004062 aryl sulfotransferase activity(GO:0004062)
0.1 1.7 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.1 1.9 GO:0019789 SUMO transferase activity(GO:0019789)
0.1 1.2 GO:0008494 translation activator activity(GO:0008494)
0.1 9.6 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 1.1 GO:0070567 cytidylyltransferase activity(GO:0070567)
0.1 2.3 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.1 6.7 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.1 9.9 GO:0019208 phosphatase regulator activity(GO:0019208)
0.1 13.6 GO:0008083 growth factor activity(GO:0008083)
0.1 7.2 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.1 1.0 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.1 50.2 GO:0005198 structural molecule activity(GO:0005198)
0.1 0.6 GO:0031702 angiotensin receptor binding(GO:0031701) type 1 angiotensin receptor binding(GO:0031702)
0.1 0.2 GO:0016534 cyclin-dependent protein kinase 5 activator activity(GO:0016534)
0.1 0.2 GO:0034988 Fc-gamma receptor I complex binding(GO:0034988)
0.1 1.4 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.1 0.2 GO:0035403 histone kinase activity (H3-T6 specific)(GO:0035403)
0.1 2.4 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 1.1 GO:0070403 NAD+ binding(GO:0070403)
0.0 4.4 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.5 GO:0051378 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.0 1.4 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 1.8 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 5.1 GO:0019902 phosphatase binding(GO:0019902)
0.0 0.3 GO:0043533 inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.0 6.9 GO:0051082 unfolded protein binding(GO:0051082)
0.0 1.6 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 1.4 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.0 4.6 GO:0008013 beta-catenin binding(GO:0008013)
0.0 1.0 GO:0008242 omega peptidase activity(GO:0008242)
0.0 0.7 GO:0043274 phospholipase binding(GO:0043274)
0.0 1.4 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 0.1 GO:0052593 tryptamine:oxygen oxidoreductase (deaminating) activity(GO:0052593) aminoacetone:oxygen oxidoreductase(deaminating) activity(GO:0052594) aliphatic-amine oxidase activity(GO:0052595) phenethylamine:oxygen oxidoreductase (deaminating) activity(GO:0052596)
0.0 0.3 GO:0005328 neurotransmitter:sodium symporter activity(GO:0005328)
0.0 0.6 GO:0022832 voltage-gated ion channel activity(GO:0005244) voltage-gated channel activity(GO:0022832)
0.0 20.2 GO:0005509 calcium ion binding(GO:0005509)
0.0 2.3 GO:0008237 metallopeptidase activity(GO:0008237)
0.0 4.1 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 0.2 GO:0009922 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0 0.1 GO:0004594 pantothenate kinase activity(GO:0004594)
0.0 0.7 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 1.8 GO:0017048 Rho GTPase binding(GO:0017048)
0.0 0.1 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.0 1.2 GO:0008565 protein transporter activity(GO:0008565)
0.0 0.0 GO:0005128 erythropoietin receptor binding(GO:0005128)
0.0 0.4 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 0.1 GO:0070410 co-SMAD binding(GO:0070410)
0.0 2.0 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 1.5 GO:0051020 GTPase binding(GO:0051020)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 43.1 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.6 60.2 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.5 30.1 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.5 12.5 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.4 9.0 PID S1P S1P4 PATHWAY S1P4 pathway
0.3 5.5 ST STAT3 PATHWAY STAT3 Pathway
0.3 77.5 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.3 16.5 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.2 9.3 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.2 11.1 PID CD40 PATHWAY CD40/CD40L signaling
0.2 7.0 PID EPHA FWDPATHWAY EPHA forward signaling
0.2 16.2 PID EPHB FWD PATHWAY EPHB forward signaling
0.2 23.4 PID NOTCH PATHWAY Notch signaling pathway
0.2 13.3 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.2 12.0 PID TGFBR PATHWAY TGF-beta receptor signaling
0.1 4.9 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.1 3.6 SIG IL4RECEPTOR IN B LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes
0.1 9.9 PID RHOA PATHWAY RhoA signaling pathway
0.1 3.5 PID LYMPH ANGIOGENESIS PATHWAY VEGFR3 signaling in lymphatic endothelium
0.1 8.1 PID PI3KCI PATHWAY Class I PI3K signaling events
0.1 5.2 PID ALK1 PATHWAY ALK1 signaling events
0.1 9.3 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.1 5.2 ST ADRENERGIC Adrenergic Pathway
0.1 4.4 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.1 4.3 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.1 4.3 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling
0.1 5.0 PID PTP1B PATHWAY Signaling events mediated by PTP1B
0.1 6.6 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
0.1 7.7 PID PLK1 PATHWAY PLK1 signaling events
0.1 2.7 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
0.1 2.7 PID IL1 PATHWAY IL1-mediated signaling events
0.1 1.8 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.1 8.4 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.1 10.4 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.1 3.7 SIG PIP3 SIGNALING IN CARDIAC MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.1 2.6 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.1 0.5 PID S1P S1P2 PATHWAY S1P2 pathway
0.1 3.3 PID RHODOPSIN PATHWAY Visual signal transduction: Rods
0.1 8.2 PID P73PATHWAY p73 transcription factor network
0.1 4.0 PID RAC1 PATHWAY RAC1 signaling pathway
0.1 4.1 PID FGF PATHWAY FGF signaling pathway
0.1 10.0 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.1 21.4 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.1 5.8 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.1 17.1 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.6 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 1.4 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 1.3 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.0 0.8 PID THROMBIN PAR1 PATHWAY PAR1-mediated thrombin signaling events
0.0 0.8 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 1.2 PID CMYB PATHWAY C-MYB transcription factor network
0.0 0.3 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.8 PID ILK PATHWAY Integrin-linked kinase signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 31.9 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.6 17.0 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.6 15.1 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.6 21.3 REACTOME DESTABILIZATION OF MRNA BY KSRP Genes involved in Destabilization of mRNA by KSRP
0.4 11.7 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.4 18.3 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.4 18.2 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.4 18.5 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.4 6.8 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.4 6.7 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.3 2.8 REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP Genes involved in Destabilization of mRNA by Tristetraprolin (TTP)
0.3 16.3 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.3 12.9 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.3 10.0 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.3 8.7 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.3 3.6 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.3 29.4 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.3 17.0 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.3 4.1 REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 Genes involved in Signaling by activated point mutants of FGFR1
0.2 6.4 REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY Genes involved in Adenylate cyclase inhibitory pathway
0.2 1.6 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.2 26.2 REACTOME CELL JUNCTION ORGANIZATION Genes involved in Cell junction organization
0.2 8.6 REACTOME SIGNALING BY FGFR1 MUTANTS Genes involved in Signaling by FGFR1 mutants
0.2 11.2 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.2 1.1 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.2 6.8 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.2 7.0 REACTOME FORMATION OF INCISION COMPLEX IN GG NER Genes involved in Formation of incision complex in GG-NER
0.2 10.1 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.2 6.5 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.2 4.6 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.2 2.6 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.2 11.5 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.1 3.4 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 6.7 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 6.9 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.1 2.2 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.1 3.1 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.1 2.2 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.1 3.0 REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION Genes involved in 3' -UTR-mediated translational regulation
0.1 18.5 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.1 9.9 REACTOME AMYLOIDS Genes involved in Amyloids
0.1 3.1 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.1 3.3 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 2.9 REACTOME SEMA3A PAK DEPENDENT AXON REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
0.1 5.3 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.1 3.1 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.1 5.5 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.1 30.0 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.1 1.4 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 2.1 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.1 1.4 REACTOME ER PHAGOSOME PATHWAY Genes involved in ER-Phagosome pathway
0.1 3.3 REACTOME GABA B RECEPTOR ACTIVATION Genes involved in GABA B receptor activation
0.1 3.6 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 3.2 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.1 2.0 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.1 2.2 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.1 0.8 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.1 1.1 REACTOME RNA POL I TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.1 3.7 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 1.4 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.1 5.3 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 0.8 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.0 0.5 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.0 0.6 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 1.7 REACTOME MUSCLE CONTRACTION Genes involved in Muscle contraction
0.0 1.0 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 0.8 REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.0 2.9 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 0.4 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.0 5.3 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 0.2 REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.0 1.3 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.4 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 1.0 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.0 0.2 REACTOME ACTIVATION OF NF KAPPAB IN B CELLS Genes involved in Activation of NF-kappaB in B Cells
0.0 0.9 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription