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SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for KLF14_SP8
Z-value: 1.51
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Transcription factors associated with KLF14_SP8
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| KLF14 | hg19_v2_chr7_-_130418888_130418888 | -0.23 | 3.4e-01 | Click! |
| SP8 | hg19_v2_chr7_-_20826504_20826526 | 0.12 | 6.3e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_+_228362251 Show fit | 4.52 |
ENST00000546123.1
|
IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae) |
|
| chr3_+_49507674 Show fit | 3.40 |
ENST00000431960.1
ENST00000452317.1 ENST00000435508.2 ENST00000452060.1 ENST00000428779.1 ENST00000419218.1 ENST00000430636.1 |
dystroglycan 1 (dystrophin-associated glycoprotein 1) |
|
| chr11_-_64851496 Show fit | 2.63 |
ENST00000404147.3
ENST00000275517.3 |
cell division cycle associated 5 |
|
| chr14_+_74551650 Show fit | 2.53 |
ENST00000554938.1
|
lin-52 homolog (C. elegans) |
|
| chr12_+_110718428 Show fit | 2.16 |
ENST00000552636.1
|
ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 |
|
| chr2_-_128615517 Show fit | 2.10 |
ENST00000409698.1
|
polymerase (RNA) II (DNA directed) polypeptide D |
|
| chr7_+_36192855 Show fit | 2.09 |
ENST00000534978.1
|
endonuclease/exonuclease/phosphatase family domain containing 1 |
|
| chr12_-_109125285 Show fit | 2.08 |
ENST00000552871.1
ENST00000261401.3 |
coronin, actin binding protein, 1C |
|
| chr7_+_36192758 Show fit | 2.06 |
ENST00000242108.4
|
endonuclease/exonuclease/phosphatase family domain containing 1 |
|
| chr13_+_53029564 Show fit | 2.00 |
ENST00000468284.1
ENST00000378034.3 ENST00000258607.5 ENST00000378037.5 |
cytoskeleton associated protein 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of KLF14_SP8
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.5 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 1.5 | 4.5 | GO:0016340 | calcium-dependent cell-matrix adhesion(GO:0016340) |
| 0.4 | 4.5 | GO:0010032 | meiotic chromosome condensation(GO:0010032) |
| 0.0 | 4.5 | GO:0007062 | sister chromatid cohesion(GO:0007062) |
| 0.1 | 3.9 | GO:0031163 | iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163) |
| 0.4 | 3.8 | GO:2000286 | receptor internalization involved in canonical Wnt signaling pathway(GO:2000286) |
| 0.1 | 3.8 | GO:0007099 | centriole replication(GO:0007099) |
| 0.3 | 3.5 | GO:0006065 | UDP-glucuronate biosynthetic process(GO:0006065) |
| 0.1 | 3.4 | GO:0090503 | RNA phosphodiester bond hydrolysis, exonucleolytic(GO:0090503) |
| 0.2 | 3.2 | GO:0007253 | cytoplasmic sequestering of NF-kappaB(GO:0007253) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.1 | GO:0044439 | microbody part(GO:0044438) peroxisomal part(GO:0044439) |
| 0.4 | 5.0 | GO:0000796 | condensin complex(GO:0000796) |
| 0.0 | 4.6 | GO:0000776 | kinetochore(GO:0000776) |
| 0.4 | 4.5 | GO:0016011 | dystroglycan complex(GO:0016011) |
| 0.3 | 4.5 | GO:0000808 | origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664) |
| 0.0 | 3.9 | GO:0031901 | early endosome membrane(GO:0031901) |
| 0.0 | 3.9 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.1 | 3.8 | GO:1990023 | mitotic spindle midzone(GO:1990023) |
| 0.2 | 3.6 | GO:0097470 | ribbon synapse(GO:0097470) |
| 0.2 | 3.4 | GO:0008278 | cohesin complex(GO:0008278) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.0 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.1 | 5.4 | GO:0003899 | DNA-directed RNA polymerase activity(GO:0003899) |
| 0.5 | 4.5 | GO:0043237 | laminin-1 binding(GO:0043237) |
| 0.1 | 4.3 | GO:0005487 | nucleocytoplasmic transporter activity(GO:0005487) |
| 0.1 | 4.2 | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) |
| 0.3 | 4.1 | GO:0030976 | thiamine pyrophosphate binding(GO:0030976) |
| 0.1 | 3.9 | GO:0004535 | poly(A)-specific ribonuclease activity(GO:0004535) |
| 0.1 | 3.8 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
| 0.0 | 3.8 | GO:0101005 | ubiquitinyl hydrolase activity(GO:0101005) |
| 0.0 | 3.7 | GO:0048365 | Rac GTPase binding(GO:0048365) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 12.8 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.1 | 8.6 | PID E2F PATHWAY | E2F transcription factor network |
| 0.1 | 6.0 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.1 | 4.6 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.4 | 4.3 | ST PAC1 RECEPTOR PATHWAY | PAC1 Receptor Pathway |
| 0.0 | 3.8 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.1 | 2.4 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.0 | 2.4 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.0 | 2.2 | PID ATM PATHWAY | ATM pathway |
| 0.0 | 2.1 | PID CDC42 PATHWAY | CDC42 signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.2 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.4 | 6.8 | REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION | Genes involved in E2F-enabled inhibition of pre-replication complex formation |
| 0.1 | 5.6 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.1 | 4.9 | REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.1 | 4.0 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.0 | 3.9 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.1 | 3.6 | REACTOME G0 AND EARLY G1 | Genes involved in G0 and Early G1 |
| 0.1 | 3.5 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.0 | 3.5 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.1 | 3.1 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |