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SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for KLF16_SP2
Z-value: 4.80
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Transcription factors associated with KLF16_SP2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SP2 | hg19_v2_chr17_+_45973516_45973618 | -0.91 | 2.5e-08 | Click! |
| KLF16 | hg19_v2_chr19_-_1863567_1863586 | 0.08 | 7.5e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_+_55795493 Show fit | 46.05 |
ENST00000309383.1
|
BR serine/threonine kinase 1 |
|
| chr19_-_8675559 Show fit | 34.88 |
ENST00000597188.1
|
ADAM metallopeptidase with thrombospondin type 1 motif, 10 |
|
| chr16_+_1203194 Show fit | 30.89 |
ENST00000348261.5
ENST00000358590.4 |
calcium channel, voltage-dependent, T type, alpha 1H subunit |
|
| chr5_+_176513895 Show fit | 28.81 |
ENST00000503708.1
ENST00000393648.2 ENST00000514472.1 ENST00000502906.1 ENST00000292410.3 ENST00000510911.1 |
fibroblast growth factor receptor 4 |
|
| chr11_-_407103 Show fit | 27.54 |
ENST00000526395.1
|
single immunoglobulin and toll-interleukin 1 receptor (TIR) domain |
|
| chr19_-_11456872 Show fit | 26.44 |
ENST00000586218.1
|
transmembrane protein 205 |
|
| chr11_+_57227981 Show fit | 25.95 |
ENST00000335099.3
|
reticulon 4 receptor-like 2 |
|
| chr7_+_5322561 Show fit | 24.75 |
ENST00000396872.3
ENST00000444741.1 ENST00000297195.4 ENST00000406453.3 |
solute carrier family 29 (equilibrative nucleoside transporter), member 4 |
|
| chr19_-_11456905 Show fit | 24.31 |
ENST00000588560.1
ENST00000592952.1 |
transmembrane protein 205 |
|
| chr19_+_589893 Show fit | 24.04 |
ENST00000251287.2
|
hyperpolarization activated cyclic nucleotide-gated potassium channel 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of KLF16_SP2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 157.6 | GO:0006414 | translational elongation(GO:0006414) |
| 7.1 | 64.0 | GO:0031444 | slow-twitch skeletal muscle fiber contraction(GO:0031444) |
| 10.3 | 62.0 | GO:0009051 | pentose-phosphate shunt, oxidative branch(GO:0009051) |
| 0.5 | 54.5 | GO:0051436 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436) regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051439) |
| 0.4 | 51.4 | GO:0006805 | xenobiotic metabolic process(GO:0006805) |
| 1.9 | 50.0 | GO:1901663 | ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663) |
| 8.3 | 49.5 | GO:1903412 | response to bile acid(GO:1903412) |
| 0.3 | 43.9 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 3.0 | 42.4 | GO:0061469 | regulation of type B pancreatic cell proliferation(GO:0061469) |
| 3.0 | 42.2 | GO:0007144 | female meiosis I(GO:0007144) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 894.0 | GO:0016021 | integral component of membrane(GO:0016021) |
| 0.7 | 96.4 | GO:0099501 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 3.1 | 74.9 | GO:0005861 | troponin complex(GO:0005861) |
| 1.6 | 74.7 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 0.5 | 62.8 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.8 | 61.0 | GO:0005761 | organellar ribosome(GO:0000313) mitochondrial ribosome(GO:0005761) |
| 1.0 | 54.9 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.4 | 52.8 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.6 | 49.8 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.1 | 47.0 | GO:0005759 | mitochondrial matrix(GO:0005759) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 159.2 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.6 | 154.9 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.5 | 77.3 | GO:0000149 | SNARE binding(GO:0000149) |
| 5.4 | 75.5 | GO:0031014 | troponin T binding(GO:0031014) |
| 1.2 | 59.0 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 11.0 | 55.1 | GO:0004345 | glucose-6-phosphate dehydrogenase activity(GO:0004345) |
| 4.0 | 47.9 | GO:0005007 | fibroblast growth factor-activated receptor activity(GO:0005007) |
| 7.3 | 43.9 | GO:0000213 | tRNA-intron endonuclease activity(GO:0000213) |
| 2.7 | 40.1 | GO:0005030 | neurotrophin receptor activity(GO:0005030) |
| 2.0 | 39.8 | GO:0039706 | co-receptor binding(GO:0039706) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 44.3 | ST GAQ PATHWAY | G alpha q Pathway |
| 0.6 | 38.8 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.4 | 37.1 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.3 | 32.6 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.4 | 29.7 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.2 | 25.5 | PID E2F PATHWAY | E2F transcription factor network |
| 0.3 | 24.6 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.3 | 24.4 | ST T CELL SIGNAL TRANSDUCTION | T Cell Signal Transduction |
| 0.9 | 23.6 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.3 | 23.0 | PID AURORA B PATHWAY | Aurora B signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 110.8 | REACTOME POTASSIUM CHANNELS | Genes involved in Potassium Channels |
| 0.6 | 96.4 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 1.0 | 73.2 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.9 | 70.9 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 1.1 | 68.6 | REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |
| 0.8 | 58.3 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 3.3 | 56.1 | REACTOME FGFR4 LIGAND BINDING AND ACTIVATION | Genes involved in FGFR4 ligand binding and activation |
| 0.7 | 54.4 | REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
| 1.7 | 50.5 | REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
| 1.8 | 44.3 | REACTOME PROCESSIVE SYNTHESIS ON THE LAGGING STRAND | Genes involved in Processive synthesis on the lagging strand |