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SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for KLF7

Z-value: 0.29

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Transcription factors associated with KLF7

Gene Symbol Gene ID Gene Info
KLF7
ENSG00000118263.10 Kruppel like factor 7

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
KLF7hg19_v2_chr2_-_208030886_2080309170.331.6e-01Click!

Activity profile of KLF7 motif

Sorted Z-values of KLF7 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr12_-_49582837 0.23 ENST00000547939.1
ENST00000546918.1
ENST00000552924.1
TUBA1A
tubulin, alpha 1a
chr17_+_19281787 0.21 ENST00000482850.1
MAPK7
mitogen-activated protein kinase 7
chr17_+_18218587 0.21 ENST00000406438.3
SMCR8
Smith-Magenis syndrome chromosome region, candidate 8
chr17_+_19282064 0.20 ENST00000603493.1
MAPK7
mitogen-activated protein kinase 7
chr17_-_48277552 0.20 ENST00000507689.1
COL1A1
collagen, type I, alpha 1
chr1_-_21948906 0.19 ENST00000374761.2
ENST00000599760.1
RAP1GAP
RAP1 GTPase activating protein
chr12_-_49582593 0.18 ENST00000295766.5
TUBA1A
tubulin, alpha 1a
chr1_-_19229218 0.18 ENST00000432718.1
ALDH4A1
aldehyde dehydrogenase 4 family, member A1
chr12_-_49581152 0.17 ENST00000550811.1
TUBA1A
tubulin, alpha 1a
chr17_-_18218237 0.16 ENST00000542570.1
TOP3A
topoisomerase (DNA) III alpha
chr7_-_47492782 0.15 ENST00000413551.1
TNS3
tensin 3
chr16_+_11439286 0.11 ENST00000312499.5
ENST00000576027.1
RMI2
RecQ mediated genome instability 2
chr3_-_178865747 0.11 ENST00000435560.1
RP11-360P21.2
RP11-360P21.2
chr2_-_74710078 0.11 ENST00000290418.4
CCDC142
coiled-coil domain containing 142
chr2_-_61765732 0.11 ENST00000443240.1
ENST00000436018.1
XPO1
exportin 1 (CRM1 homolog, yeast)
chr17_+_38375528 0.11 ENST00000583268.1
WIPF2
WAS/WASL interacting protein family, member 2
chr1_-_19229014 0.10 ENST00000538839.1
ENST00000290597.5
ALDH4A1
aldehyde dehydrogenase 4 family, member A1
chr17_-_18218270 0.10 ENST00000321105.5
TOP3A
topoisomerase (DNA) III alpha
chr16_+_81772633 0.10 ENST00000566191.1
ENST00000565272.1
ENST00000563954.1
ENST00000565054.1
RP11-960L18.1
PLCG2
RP11-960L18.1
phospholipase C, gamma 2 (phosphatidylinositol-specific)
chr19_+_39390320 0.09 ENST00000576510.1
NFKBIB
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
chr19_+_39390587 0.09 ENST00000572515.1
ENST00000392079.3
ENST00000575359.1
ENST00000313582.5
NFKBIB
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
chr1_-_157108266 0.08 ENST00000326786.4
ETV3
ets variant 3
chr1_-_19229248 0.08 ENST00000375341.3
ALDH4A1
aldehyde dehydrogenase 4 family, member A1
chr11_+_18417948 0.08 ENST00000542179.1
LDHA
lactate dehydrogenase A
chr5_+_141348721 0.08 ENST00000507163.1
ENST00000394519.1
RNF14
ring finger protein 14
chr18_+_72166564 0.07 ENST00000583216.1
ENST00000581912.1
ENST00000582589.1
CNDP2
CNDP dipeptidase 2 (metallopeptidase M20 family)
chr8_+_17104401 0.07 ENST00000324815.3
ENST00000518038.1
VPS37A
vacuolar protein sorting 37 homolog A (S. cerevisiae)
chr6_+_43603552 0.06 ENST00000372171.4
MAD2L1BP
MAD2L1 binding protein
chr2_+_74710194 0.06 ENST00000410003.1
ENST00000442235.2
ENST00000233623.5
TTC31
tetratricopeptide repeat domain 31
chr19_-_39390440 0.06 ENST00000249396.7
ENST00000414941.1
ENST00000392081.2
SIRT2
sirtuin 2
chr19_-_39390212 0.05 ENST00000437828.1
SIRT2
sirtuin 2
chr9_+_130565487 0.04 ENST00000373225.3
ENST00000431857.1
FPGS
folylpolyglutamate synthase
chr5_+_141348598 0.04 ENST00000394520.2
ENST00000347642.3
RNF14
ring finger protein 14
chr20_+_2821366 0.04 ENST00000453689.1
ENST00000417508.1
VPS16
vacuolar protein sorting 16 homolog (S. cerevisiae)
chr9_+_130565147 0.04 ENST00000373247.2
ENST00000373245.1
ENST00000393706.2
ENST00000373228.1
FPGS
folylpolyglutamate synthase
chr1_+_28157273 0.04 ENST00000311772.5
ENST00000236412.7
ENST00000373931.4
PPP1R8
protein phosphatase 1, regulatory subunit 8
chr22_-_30987849 0.04 ENST00000402284.3
ENST00000354694.7
PES1
pescadillo ribosomal biogenesis factor 1
chr17_+_38375574 0.04 ENST00000323571.4
ENST00000585043.1
ENST00000394103.3
ENST00000536600.1
WIPF2
WAS/WASL interacting protein family, member 2
chr1_-_6453399 0.04 ENST00000608083.1
ACOT7
acyl-CoA thioesterase 7
chr12_+_1099675 0.04 ENST00000545318.2
ERC1
ELKS/RAB6-interacting/CAST family member 1
chr22_-_30987837 0.04 ENST00000335214.6
PES1
pescadillo ribosomal biogenesis factor 1
chr17_-_42462688 0.04 ENST00000377068.3
ITGA2B
integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
chr2_+_113479063 0.03 ENST00000327581.4
NT5DC4
5'-nucleotidase domain containing 4
chr19_-_39390350 0.03 ENST00000447739.1
ENST00000358931.5
ENST00000407552.1
SIRT2
sirtuin 2
chr19_-_40931891 0.03 ENST00000357949.4
SERTAD1
SERTA domain containing 1
chr9_+_130565568 0.03 ENST00000423577.1
FPGS
folylpolyglutamate synthase
chr6_+_30585486 0.03 ENST00000259873.4
ENST00000506373.2
MRPS18B
mitochondrial ribosomal protein S18B
chr20_-_2821271 0.01 ENST00000448755.1
ENST00000360652.2
PCED1A
PC-esterase domain containing 1A
chr3_-_33138624 0.01 ENST00000445488.2
ENST00000307377.8
ENST00000440656.1
ENST00000436768.1
ENST00000307363.5
GLB1
galactosidase, beta 1
chr1_+_87380299 0.01 ENST00000370551.4
ENST00000370550.5
HS2ST1
heparan sulfate 2-O-sulfotransferase 1
chr19_+_58011258 0.01 ENST00000593916.1
ENST00000598770.1
ENST00000599847.1
ENST00000282292.4
ZNF773
zinc finger protein 773
chr9_-_35812140 0.01 ENST00000497810.1
ENST00000396638.2
ENST00000484764.1
SPAG8
sperm associated antigen 8
chr16_+_20499024 0.00 ENST00000593357.1
AC137056.1
Uncharacterized protein; cDNA FLJ34659 fis, clone KIDNE2018863
chr6_-_33239712 0.00 ENST00000436044.2
VPS52
vacuolar protein sorting 52 homolog (S. cerevisiae)

Network of associatons between targets according to the STRING database.

First level regulatory network of KLF7

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0070376 regulation of ERK5 cascade(GO:0070376) negative regulation of ERK5 cascade(GO:0070377)
0.1 0.2 GO:1903697 negative regulation of microvillus assembly(GO:1903697)
0.1 0.4 GO:0019470 4-hydroxyproline catabolic process(GO:0019470)
0.0 0.2 GO:0044691 tooth eruption(GO:0044691)
0.0 0.1 GO:0070446 cellular response to caloric restriction(GO:0061433) negative regulation of oligodendrocyte progenitor proliferation(GO:0070446)
0.0 0.1 GO:0046901 tetrahydrofolylpolyglutamate biosynthetic process(GO:0046901)
0.0 0.1 GO:0002316 follicular B cell differentiation(GO:0002316)
0.0 0.2 GO:1901098 positive regulation of autophagosome maturation(GO:1901098)
0.0 0.3 GO:0006265 DNA topological change(GO:0006265)
0.0 0.1 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0005584 collagen type I trimer(GO:0005584)
0.0 0.2 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.0 0.1 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.0 0.1 GO:0072687 meiotic spindle(GO:0072687)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0003842 1-pyrroline-5-carboxylate dehydrogenase activity(GO:0003842)
0.0 0.1 GO:0046970 NAD-dependent histone deacetylase activity (H4-K16 specific)(GO:0046970)
0.0 0.1 GO:0008841 tetrahydrofolylpolyglutamate synthase activity(GO:0004326) dihydrofolate synthase activity(GO:0008841)
0.0 0.3 GO:0003917 DNA topoisomerase type I activity(GO:0003917)
0.0 0.1 GO:0102008 cytosolic dipeptidase activity(GO:0102008)
0.0 0.4 GO:0004707 MAP kinase activity(GO:0004707)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.0 0.6 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway