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SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for MAFA

Z-value: 0.29

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Transcription factors associated with MAFA

Gene Symbol Gene ID Gene Info
ENSG00000182759.3 MAF bZIP transcription factor A

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
MAFAhg19_v2_chr8_-_144512576_1445125760.223.6e-01Click!

Activity profile of MAFA motif

Sorted Z-values of MAFA motif

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_153517473 0.62 ENST00000368715.1
S100 calcium binding protein A4
chr6_+_7727030 0.60 ENST00000283147.6
bone morphogenetic protein 6
chr1_+_66458072 0.41 ENST00000423207.2
phosphodiesterase 4B, cAMP-specific
chr9_+_97488939 0.28 ENST00000277198.2
ENST00000297979.5
chromosome 9 open reading frame 3
chr12_+_56546363 0.26 ENST00000551834.1
ENST00000552568.1
myosin, light chain 6B, alkali, smooth muscle and non-muscle
chr1_+_221054411 0.25 ENST00000427693.1
H2.0-like homeobox
chr7_-_86849836 0.22 ENST00000455575.1
transmembrane protein 243, mitochondrial
chr15_+_80696666 0.21 ENST00000303329.4
aryl-hydrocarbon receptor nuclear translocator 2
chr9_+_2622085 0.20 ENST00000382099.2
very low density lipoprotein receptor
chr1_-_57045228 0.19 ENST00000371250.3
phosphatidic acid phosphatase type 2B
chr22_+_48972118 0.19 ENST00000358295.5
family with sequence similarity 19 (chemokine (C-C motif)-like), member A5
chr7_-_86849883 0.19 ENST00000433078.1
transmembrane protein 243, mitochondrial
chr2_+_103236004 0.19 ENST00000233969.2
solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
chr2_+_191745560 0.19 ENST00000338435.4
glutaminase
chr20_+_306221 0.17 ENST00000342665.2
SRY (sex determining region Y)-box 12
chr1_+_221054584 0.17 ENST00000549319.1
H2.0-like homeobox
chr8_+_145438870 0.17 ENST00000527931.1
family with sequence similarity 203, member B
chr12_+_21654714 0.17 ENST00000542038.1
ENST00000540141.1
ENST00000229314.5
golgi transport 1B
chrX_-_47509994 0.16 ENST00000343894.4
ELK1, member of ETS oncogene family
chr4_+_74606223 0.16 ENST00000307407.3
ENST00000401931.1
interleukin 8
chr16_+_67312049 0.16 ENST00000565899.1
pleckstrin homology domain containing, family G (with RhoGef domain) member 4
chr20_+_306177 0.16 ENST00000544632.1
SRY (sex determining region Y)-box 12
chr11_+_777562 0.15 ENST00000530083.1
Protein LOC100506518
chr19_+_36103631 0.15 ENST00000203166.5
ENST00000379045.2
HAUS augmin-like complex, subunit 5
chr19_+_39647271 0.15 ENST00000599657.1
p21 protein (Cdc42/Rac)-activated kinase 4
chr10_-_70231639 0.14 ENST00000551118.2
ENST00000358410.3
ENST00000399180.2
ENST00000399179.2
DNA replication helicase/nuclease 2
chr7_-_150754935 0.14 ENST00000297518.4
cyclin-dependent kinase 5
chr6_-_24489842 0.14 ENST00000230036.1
glycosylphosphatidylinositol specific phospholipase D1
chr17_-_3796334 0.14 ENST00000381771.2
ENST00000348335.2
ENST00000158166.5
calcium/calmodulin-dependent protein kinase kinase 1, alpha
chr15_-_90456156 0.14 ENST00000357484.5
chromosome 15 open reading frame 38
chr15_-_66858298 0.14 ENST00000537670.1
lactase-like
chr19_+_38880695 0.13 ENST00000587947.1
ENST00000338502.4
sprouty-related, EVH1 domain containing 3
chr18_-_2982869 0.13 ENST00000584915.1
lipin 2
chr9_-_130712995 0.13 ENST00000373084.4
family with sequence similarity 102, member A
chr2_-_26205550 0.13 ENST00000405914.1
kinesin family member 3C
chr9_+_2621950 0.12 ENST00000382096.1
very low density lipoprotein receptor
chr12_+_79258547 0.12 ENST00000457153.2
synaptotagmin I
chr3_+_196439275 0.11 ENST00000296333.5
phosphatidylinositol glycan anchor biosynthesis, class X
chr10_-_102289611 0.11 ENST00000299166.4
ENST00000370320.4
ENST00000531258.1
ENST00000370322.1
ENST00000535773.1
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa
SEC31 homolog B (S. cerevisiae)
chr9_-_100000957 0.11 ENST00000366109.2
ENST00000607322.1
RP11-498P14.5
chr2_+_26915584 0.11 ENST00000302909.3
potassium channel, subfamily K, member 3
chr9_+_100000717 0.11 ENST00000375205.2
ENST00000357054.1
ENST00000395220.1
ENST00000375202.2
ENST00000411667.2
coiled-coil domain containing 180
chr14_+_50779029 0.11 ENST00000245448.6
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
chr3_-_131736593 0.11 ENST00000514999.1
copine IV
chr15_+_90744745 0.11 ENST00000558051.1
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B
chr6_-_74161977 0.10 ENST00000370318.1
ENST00000370315.3
Mab-21 domain containing 1
chr12_+_79258444 0.10 ENST00000261205.4
synaptotagmin I
chrX_-_53310791 0.10 ENST00000375365.2
IQ motif and Sec7 domain 2
chr9_+_2621798 0.10 ENST00000382100.3
very low density lipoprotein receptor
chr17_-_47925379 0.10 ENST00000352793.2
ENST00000334568.4
ENST00000398154.1
ENST00000436235.1
ENST00000326219.5
tachykinin 4 (hemokinin)
chr14_-_54317532 0.10 ENST00000418927.1
AL162759.1
chr15_-_23086259 0.09 ENST00000538684.1
non imprinted in Prader-Willi/Angelman syndrome 1
chr2_+_191745535 0.09 ENST00000320717.3
glutaminase
chr5_-_179285785 0.09 ENST00000520698.1
ENST00000518235.1
ENST00000376931.2
ENST00000518219.1
ENST00000521333.1
ENST00000523084.1
chromosome 5 open reading frame 45
chr10_+_135122906 0.09 ENST00000368554.4
zinc finger protein 511
chr19_-_51141196 0.08 ENST00000338916.4
synaptotagmin III
chr19_+_12949251 0.08 ENST00000251472.4
microtubule associated serine/threonine kinase 1
chr9_+_131549610 0.08 ENST00000223865.8
TBC1 domain family, member 13
chr11_-_93276514 0.08 ENST00000526869.1
single-pass membrane protein with coiled-coil domains 4
chr17_-_41623009 0.08 ENST00000393664.2
ets variant 4
chr16_+_58074069 0.08 ENST00000570065.1
matrix metallopeptidase 15 (membrane-inserted)
chr12_+_120137573 0.07 ENST00000535109.1
Uncharacterized protein
chr5_+_176853702 0.07 ENST00000507633.1
ENST00000393576.3
ENST00000355958.5
ENST00000528793.1
ENST00000512684.1
G protein-coupled receptor kinase 6
chr14_+_50779071 0.07 ENST00000426751.2
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
chrX_-_65859096 0.07 ENST00000456230.2
ectodysplasin A2 receptor
chr1_+_90286562 0.07 ENST00000525774.1
ENST00000337338.5
leucine rich repeat containing 8 family, member D
chr15_-_90456114 0.07 ENST00000398333.3
C15orf38-AP3S2 readthrough
chr8_-_63998590 0.07 ENST00000260116.4
tocopherol (alpha) transfer protein
chr9_-_130889990 0.07 ENST00000449878.1
prostaglandin E synthase 2
chr3_-_49823941 0.06 ENST00000321599.4
ENST00000395238.1
ENST00000468463.1
ENST00000460540.1
inositol hexakisphosphate kinase 1
chr15_-_23086394 0.06 ENST00000337435.4
non imprinted in Prader-Willi/Angelman syndrome 1
chr17_+_25936862 0.06 ENST00000582410.1
kinase suppressor of ras 1
chr7_-_30029328 0.06 ENST00000425819.2
ENST00000409570.1
secernin 1
chr9_-_28670283 0.06 ENST00000379992.2
leucine rich repeat and Ig domain containing 2
chrX_-_47509887 0.06 ENST00000247161.3
ENST00000592066.1
ENST00000376983.3
ELK1, member of ETS oncogene family
chr3_+_196439170 0.06 ENST00000392391.3
ENST00000314118.4
phosphatidylinositol glycan anchor biosynthesis, class X
chr13_-_103426112 0.06 ENST00000376032.4
ENST00000376029.3
testis expressed 30
chrX_-_63425561 0.06 ENST00000374869.3
ENST00000330258.3
APC membrane recruitment protein 1
chr12_-_21654479 0.05 ENST00000421138.2
ENST00000444129.2
ENST00000539672.1
ENST00000542432.1
ENST00000536964.1
ENST00000536240.1
ENST00000396093.3
ENST00000314748.6
RecQ protein-like (DNA helicase Q1-like)
chr14_+_24605389 0.05 ENST00000382708.3
ENST00000561435.1
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr19_-_4124079 0.05 ENST00000394867.4
ENST00000262948.5
mitogen-activated protein kinase kinase 2
chr11_-_75380165 0.05 ENST00000304771.3
microtubule-associated protein 6
chr10_+_124221036 0.05 ENST00000368984.3
HtrA serine peptidase 1
chr11_-_70507901 0.05 ENST00000449833.2
ENST00000357171.3
ENST00000449116.2
SH3 and multiple ankyrin repeat domains 2
chr17_+_18759612 0.05 ENST00000432893.2
ENST00000414602.1
ENST00000574522.1
ENST00000570450.1
ENST00000419071.2
phosphoribosyl pyrophosphate synthetase-associated protein 2
chr10_-_79397391 0.05 ENST00000286628.8
ENST00000406533.3
ENST00000354353.5
ENST00000404857.1
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
chr6_-_143832793 0.05 ENST00000438118.2
fucosidase, alpha-L- 2, plasma
chr10_+_102505468 0.05 ENST00000361791.3
ENST00000355243.3
ENST00000428433.1
ENST00000370296.2
paired box 2
chr4_+_72052964 0.05 ENST00000264485.5
ENST00000425175.1
solute carrier family 4 (sodium bicarbonate cotransporter), member 4
chr19_+_33182823 0.05 ENST00000397061.3
nudix (nucleoside diphosphate linked moiety X)-type motif 19
chr2_+_118846008 0.05 ENST00000245787.4
insulin induced gene 2
chr13_-_103426081 0.05 ENST00000376022.1
ENST00000376021.4
testis expressed 30
chr12_+_53817633 0.04 ENST00000257863.4
ENST00000550311.1
ENST00000379791.3
anti-Mullerian hormone receptor, type II
chr1_-_32403903 0.04 ENST00000344035.6
ENST00000356536.3
protein tyrosine phosphatase type IVA, member 2
chr1_-_216978709 0.04 ENST00000360012.3
estrogen-related receptor gamma
chr3_+_184016986 0.04 ENST00000417952.1
proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
chr1_+_110754094 0.04 ENST00000369787.3
ENST00000413138.3
ENST00000438661.2
potassium voltage-gated channel, Shaw-related subfamily, member 4
chr5_+_60933634 0.04 ENST00000505642.1
chromosome 5 open reading frame 64
chr19_-_37958318 0.04 ENST00000316950.6
ENST00000591710.1
zinc finger protein 569
chr16_-_87525651 0.04 ENST00000268616.4
zinc finger, CCHC domain containing 14
chr22_-_30662828 0.04 ENST00000403463.1
ENST00000215781.2
oncostatin M
chr13_+_53226963 0.04 ENST00000343788.6
ENST00000535397.1
ENST00000310528.8
SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae)
chrX_-_65858865 0.04 ENST00000374719.3
ENST00000450752.1
ENST00000451436.2
ectodysplasin A2 receptor
chr10_-_79397479 0.04 ENST00000404771.3
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
chr5_-_94620239 0.04 ENST00000515393.1
multiple C2 domains, transmembrane 1
chr11_-_57518848 0.04 ENST00000436147.3
BTB (POZ) domain containing 18
chr12_+_54943134 0.04 ENST00000243052.3
phosphodiesterase 1B, calmodulin-dependent
chr17_+_38465441 0.03 ENST00000577646.1
ENST00000254066.5
retinoic acid receptor, alpha
chr21_+_44589118 0.03 ENST00000291554.2
crystallin, alpha A
chr17_-_17109579 0.03 ENST00000321560.3
phospholipase D family, member 6
chr5_-_179285848 0.03 ENST00000403396.2
ENST00000292586.6
chromosome 5 open reading frame 45
chr7_-_73133959 0.03 ENST00000395155.3
ENST00000395154.3
ENST00000222812.3
ENST00000395156.3
syntaxin 1A (brain)
chr5_+_139739772 0.03 ENST00000506757.2
ENST00000230993.6
ENST00000506545.1
ENST00000432095.2
ENST00000507527.1
solute carrier family 4, sodium bicarbonate cotransporter, member 9
chr10_-_118897567 0.03 ENST00000369206.5
ventral anterior homeobox 1
chr2_+_33172221 0.03 ENST00000354476.3
latent transforming growth factor beta binding protein 1
chr7_-_135412925 0.03 ENST00000354042.4
solute carrier family 13 (sodium/sulfate symporter), member 4
chr14_+_24600484 0.03 ENST00000267426.5
fat storage-inducing transmembrane protein 1
chr1_-_32403370 0.03 ENST00000534796.1
protein tyrosine phosphatase type IVA, member 2
chr7_-_30029367 0.03 ENST00000242059.5
secernin 1
chr19_-_43099070 0.03 ENST00000244336.5
carcinoembryonic antigen-related cell adhesion molecule 8
chrX_-_153141783 0.03 ENST00000458029.1
L1 cell adhesion molecule
chr3_+_141121164 0.03 ENST00000510338.1
ENST00000504673.1
zinc finger and BTB domain containing 38
chr19_-_43099109 0.02 ENST00000599005.1
carcinoembryonic antigen-related cell adhesion molecule 8
chr19_-_50464338 0.02 ENST00000426971.2
ENST00000447370.2
sialic acid binding Ig-like lectin 11
chr6_+_42896865 0.02 ENST00000372836.4
ENST00000394142.3
canopy FGF signaling regulator 3
chr4_+_72053017 0.02 ENST00000351898.6
solute carrier family 4 (sodium bicarbonate cotransporter), member 4
chr7_+_100860949 0.02 ENST00000305105.2
zinc finger, HIT-type containing 1
chr19_+_18451439 0.02 ENST00000597431.2
pyroglutamyl-peptidase I
chr10_+_120967072 0.02 ENST00000392870.2
G protein-coupled receptor kinase 5
chr10_+_102505954 0.02 ENST00000556085.1
ENST00000427256.1
paired box 2
chr11_-_104817919 0.02 ENST00000533252.1
caspase 4, apoptosis-related cysteine peptidase
chr11_+_107461948 0.02 ENST00000265840.7
ENST00000443271.2
ELMO/CED-12 domain containing 1
chr17_-_42019836 0.01 ENST00000225992.3
pancreatic polypeptide
chr6_+_22221010 0.01 ENST00000567753.1
RP11-524C21.2
chr1_-_13331692 0.01 ENST00000353410.5
ENST00000376173.3
PRAME family member 3
chr7_-_108168580 0.01 ENST00000453085.1
patatin-like phospholipase domain containing 8
chr7_+_142749417 0.01 ENST00000418316.1
olfactory receptor, family 6, subfamily V, member 1
chr6_-_139613269 0.01 ENST00000358430.3
taxilin beta
chrX_+_118892545 0.01 ENST00000343905.3
sosondowah ankyrin repeat domain family member D
chr8_-_89339705 0.01 ENST00000286614.6
matrix metallopeptidase 16 (membrane-inserted)
chr9_-_127905736 0.01 ENST00000336505.6
ENST00000373549.4
suppressor of cancer cell invasion
chr7_-_30029574 0.01 ENST00000426154.1
ENST00000421434.1
ENST00000434476.2
secernin 1
chr2_+_102624977 0.01 ENST00000441002.1
interleukin 1 receptor, type II
chr10_-_118897806 0.00 ENST00000277905.2
ventral anterior homeobox 1
chr17_+_31318886 0.00 ENST00000269053.3
ENST00000394638.1
sperm acrosome associated 3
chr5_-_118324200 0.00 ENST00000515439.3
ENST00000510708.1
DTW domain containing 2
chr16_+_70258261 0.00 ENST00000594734.1
FKSG63
chr1_+_202091980 0.00 ENST00000367282.5
G protein-coupled receptor 37 like 1
chr6_+_147525541 0.00 ENST00000367481.3
ENST00000546097.1
syntaxin binding protein 5 (tomosyn)

Network of associatons between targets according to the STRING database.

First level regulatory network of MAFA

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0090031 positive regulation of steroid hormone biosynthetic process(GO:0090031)
0.1 0.4 GO:0034436 glycoprotein transport(GO:0034436)
0.0 0.4 GO:0045629 negative regulation of T-helper 2 cell differentiation(GO:0045629)
0.0 0.3 GO:0006543 glutamine catabolic process(GO:0006543)
0.0 0.2 GO:0098746 fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746)
0.0 0.1 GO:1902990 DNA replication, removal of RNA primer(GO:0043137) mitotic telomere maintenance via semi-conservative replication(GO:1902990)
0.0 0.1 GO:0010983 positive regulation of high-density lipoprotein particle clearance(GO:0010983)
0.0 0.4 GO:1901078 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 0.1 GO:0035566 vestibulocochlear nerve formation(GO:0021650) regulation of metanephros size(GO:0035566)
0.0 0.1 GO:0097187 dentinogenesis(GO:0097187)
0.0 0.2 GO:0071394 cellular response to testosterone stimulus(GO:0071394)
0.0 0.1 GO:0046878 positive regulation of saliva secretion(GO:0046878)
0.0 0.1 GO:0090210 vitamin E metabolic process(GO:0042360) regulation of establishment of blood-brain barrier(GO:0090210) negative regulation of establishment of blood-brain barrier(GO:0090212)
0.0 0.1 GO:0046826 negative regulation of protein export from nucleus(GO:0046826)
0.0 0.1 GO:0060083 smooth muscle contraction involved in micturition(GO:0060083)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.0 0.2 GO:0060201 clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
0.0 0.0 GO:0034515 proteasome storage granule(GO:0034515)
0.0 0.3 GO:0016461 unconventional myosin complex(GO:0016461)
0.0 0.0 GO:0002189 ribose phosphate diphosphokinase complex(GO:0002189)
0.0 0.4 GO:0034385 very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)
0.0 0.4 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.0 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.0 0.1 GO:0070652 HAUS complex(GO:0070652)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0034189 very-low-density lipoprotein particle binding(GO:0034189)
0.0 0.6 GO:0070700 BMP receptor binding(GO:0070700)
0.0 0.3 GO:0004359 glutaminase activity(GO:0004359)
0.0 0.1 GO:0047696 beta-adrenergic receptor kinase activity(GO:0047696)
0.0 0.1 GO:0008422 beta-glucosidase activity(GO:0008422)
0.0 0.6 GO:0050786 RAGE receptor binding(GO:0050786)
0.0 0.1 GO:0017108 5'-flap endonuclease activity(GO:0017108)
0.0 0.1 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.0 0.2 GO:0030348 syntaxin-3 binding(GO:0030348)
0.0 0.1 GO:1904713 beta-catenin destruction complex binding(GO:1904713)
0.0 0.1 GO:0004727 prenylated protein tyrosine phosphatase activity(GO:0004727)
0.0 0.1 GO:0008431 vitamin E binding(GO:0008431)
0.0 0.1 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.0 0.2 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.0 0.0 GO:0004560 alpha-L-fucosidase activity(GO:0004560) fucosidase activity(GO:0015928)
0.0 0.1 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.0 0.0 GO:0005026 transforming growth factor beta receptor activity, type II(GO:0005026)
0.0 0.2 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle