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SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for MLXIPL
Z-value: 0.93
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Transcription factors associated with MLXIPL
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MLXIPL | hg19_v2_chr7_-_73038867_73038878 | 0.84 | 4.0e-06 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_+_2249308 Show fit | 3.53 |
ENST00000592877.1
ENST00000221496.4 |
anti-Mullerian hormone |
|
| chr11_-_117695449 Show fit | 3.05 |
ENST00000292079.2
|
FXYD domain containing ion transport regulator 2 |
|
| chr7_+_93551011 Show fit | 2.70 |
ENST00000248564.5
|
guanine nucleotide binding protein (G protein), gamma 11 |
|
| chr19_-_38747172 Show fit | 2.49 |
ENST00000347262.4
ENST00000591585.1 ENST00000301242.4 |
protein phosphatase 1, regulatory (inhibitor) subunit 14A |
|
| chr20_+_61867235 Show fit | 2.07 |
ENST00000342412.6
ENST00000217169.3 |
baculoviral IAP repeat containing 7 |
|
| chr6_-_24358264 Show fit | 2.03 |
ENST00000378454.3
|
doublecortin domain containing 2 |
|
| chr19_-_55677920 Show fit | 2.00 |
ENST00000524407.2
ENST00000526003.1 ENST00000534170.1 |
dynein, axonemal, assembly factor 3 |
|
| chr7_-_155437075 Show fit | 1.94 |
ENST00000401694.1
|
Protein LOC100506302 |
|
| chr2_+_8822113 Show fit | 1.91 |
ENST00000396290.1
ENST00000331129.3 |
inhibitor of DNA binding 2, dominant negative helix-loop-helix protein |
|
| chr20_-_62203808 Show fit | 1.74 |
ENST00000467148.1
|
helicase with zinc finger 2, transcriptional coactivator |
Network of associatons between targets according to the STRING database.
First level regulatory network of MLXIPL
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 7.8 | GO:1902998 | regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998) |
| 0.0 | 5.9 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 0.1 | 4.5 | GO:0044458 | motile cilium assembly(GO:0044458) |
| 0.0 | 4.1 | GO:0051436 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436) |
| 0.9 | 3.8 | GO:0010900 | negative regulation of phosphatidylcholine catabolic process(GO:0010900) |
| 0.0 | 3.8 | GO:0070126 | mitochondrial translational termination(GO:0070126) |
| 0.2 | 3.6 | GO:0051601 | exocyst localization(GO:0051601) |
| 1.2 | 3.5 | GO:0007506 | gonadal mesoderm development(GO:0007506) |
| 0.1 | 3.1 | GO:0036376 | sodium ion export from cell(GO:0036376) |
| 0.0 | 3.1 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 11.4 | GO:0015935 | small ribosomal subunit(GO:0015935) |
| 0.5 | 7.8 | GO:0034366 | spherical high-density lipoprotein particle(GO:0034366) |
| 0.0 | 6.0 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.2 | 4.1 | GO:0042627 | chylomicron(GO:0042627) |
| 0.0 | 3.8 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.0 | 3.6 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.1 | 3.1 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 0.0 | 3.1 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.0 | 2.8 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.3 | 2.5 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 11.8 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.2 | 7.7 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 0.5 | 4.0 | GO:1990932 | 5.8S rRNA binding(GO:1990932) |
| 0.4 | 3.8 | GO:0060228 | phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228) |
| 0.0 | 3.4 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.1 | 3.2 | GO:0070003 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.1 | 3.1 | GO:0005391 | sodium:potassium-exchanging ATPase activity(GO:0005391) |
| 0.1 | 3.1 | GO:0005245 | voltage-gated calcium channel activity(GO:0005245) |
| 0.0 | 2.8 | GO:0005160 | transforming growth factor beta receptor binding(GO:0005160) |
| 0.3 | 2.5 | GO:0070740 | tubulin-glutamic acid ligase activity(GO:0070740) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.9 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 4.3 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.2 | 3.5 | PID ALK2 PATHWAY | ALK2 signaling events |
| 0.0 | 2.6 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.0 | 2.4 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.1 | 1.9 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.0 | 1.9 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.1 | 1.7 | SIG PIP3 SIGNALING IN B LYMPHOCYTES | Genes related to PIP3 signaling in B lymphocytes |
| 0.0 | 1.5 | ST T CELL SIGNAL TRANSDUCTION | T Cell Signal Transduction |
| 0.0 | 1.5 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.2 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.1 | 5.7 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.0 | 5.4 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.0 | 4.1 | REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION | Genes involved in 3' -UTR-mediated translational regulation |
| 0.0 | 3.7 | REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS | Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| 0.1 | 3.6 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.0 | 3.5 | REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
| 0.1 | 3.0 | REACTOME REGULATION OF KIT SIGNALING | Genes involved in Regulation of KIT signaling |
| 0.1 | 2.8 | REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA | Genes involved in G beta:gamma signalling through PLC beta |
| 0.1 | 2.7 | REACTOME ACYL CHAIN REMODELLING OF PG | Genes involved in Acyl chain remodelling of PG |