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SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for NFE2L1
Z-value: 1.68
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Transcription factors associated with NFE2L1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NFE2L1 | hg19_v2_chr17_+_46125707_46125746 | 0.91 | 3.0e-08 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr12_-_52887034 Show fit | 19.88 |
ENST00000330722.6
|
keratin 6A |
|
| chr11_+_117947782 Show fit | 11.74 |
ENST00000522307.1
ENST00000523251.1 ENST00000437212.3 ENST00000522824.1 ENST00000522151.1 |
transmembrane protease, serine 4 |
|
| chr2_-_161056762 Show fit | 8.48 |
ENST00000428609.2
ENST00000409967.2 |
integrin, beta 6 |
|
| chr12_-_15104040 Show fit | 8.26 |
ENST00000541644.1
ENST00000545895.1 |
Rho GDP dissociation inhibitor (GDI) beta |
|
| chr2_-_161056802 Show fit | 8.13 |
ENST00000283249.2
ENST00000409872.1 |
integrin, beta 6 |
|
| chr2_-_113594279 Show fit | 7.89 |
ENST00000416750.1
ENST00000418817.1 ENST00000263341.2 |
interleukin 1, beta |
|
| chr11_+_117947724 Show fit | 7.64 |
ENST00000534111.1
|
transmembrane protease, serine 4 |
|
| chr12_-_15103621 Show fit | 6.88 |
ENST00000536592.1
|
Rho GDP dissociation inhibitor (GDI) beta |
|
| chr11_-_119999539 Show fit | 6.76 |
ENST00000541857.1
|
tripartite motif containing 29 |
|
| chr11_-_119999611 Show fit | 6.70 |
ENST00000529044.1
|
tripartite motif containing 29 |
Network of associatons between targets according to the STRING database.
First level regulatory network of NFE2L1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.3 | 27.8 | GO:0070487 | monocyte aggregation(GO:0070487) |
| 5.0 | 19.9 | GO:0051710 | cytolysis by symbiont of host cells(GO:0001897) regulation of cytolysis in other organism(GO:0051710) |
| 0.1 | 18.2 | GO:1900181 | negative regulation of protein localization to nucleus(GO:1900181) |
| 1.5 | 16.6 | GO:0038044 | transforming growth factor-beta secretion(GO:0038044) |
| 2.2 | 15.1 | GO:0071461 | cellular response to redox state(GO:0071461) |
| 1.1 | 12.0 | GO:0042905 | 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905) |
| 0.0 | 11.1 | GO:0006898 | receptor-mediated endocytosis(GO:0006898) |
| 2.3 | 6.9 | GO:0035604 | fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow(GO:0035602) fibroblast growth factor receptor signaling pathway involved in hemopoiesis(GO:0035603) fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow(GO:0035604) fibroblast growth factor receptor signaling pathway involved in mammary gland specification(GO:0060595) mammary gland bud formation(GO:0060615) branch elongation involved in salivary gland morphogenesis(GO:0060667) mesenchymal cell differentiation involved in lung development(GO:0060915) |
| 0.2 | 6.3 | GO:0016338 | calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338) |
| 1.0 | 6.0 | GO:0033031 | positive regulation of neutrophil apoptotic process(GO:0033031) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.5 | 19.9 | GO:0035692 | macrophage migration inhibitory factor receptor complex(GO:0035692) |
| 0.1 | 18.0 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.2 | 17.0 | GO:0045095 | keratin filament(GO:0045095) |
| 5.5 | 16.6 | GO:0034685 | integrin alphav-beta6 complex(GO:0034685) |
| 0.0 | 15.9 | GO:0060076 | excitatory synapse(GO:0060076) |
| 0.1 | 11.8 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.2 | 5.8 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.1 | 5.7 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.2 | 5.6 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.2 | 5.4 | GO:0005922 | connexon complex(GO:0005922) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 22.8 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.2 | 18.9 | GO:0005044 | scavenger receptor activity(GO:0005044) |
| 0.2 | 18.5 | GO:0001618 | virus receptor activity(GO:0001618) |
| 0.5 | 18.1 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.4 | 16.9 | GO:0098641 | cadherin binding involved in cell-cell adhesion(GO:0098641) |
| 1.3 | 15.1 | GO:0005094 | Rho GDP-dissociation inhibitor activity(GO:0005094) |
| 0.5 | 13.3 | GO:0005149 | interleukin-1 receptor binding(GO:0005149) |
| 0.9 | 12.0 | GO:0047035 | alcohol dehydrogenase (NAD) activity(GO:0004022) testosterone dehydrogenase (NAD+) activity(GO:0047035) |
| 0.0 | 7.2 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.6 | 6.9 | GO:0005007 | fibroblast growth factor-activated receptor activity(GO:0005007) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 27.7 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.4 | 17.0 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.1 | 17.0 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.1 | 9.5 | PID FGF PATHWAY | FGF signaling pathway |
| 0.2 | 8.2 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.1 | 6.2 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.1 | 5.3 | PID SYNDECAN 2 PATHWAY | Syndecan-2-mediated signaling events |
| 0.0 | 4.2 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.1 | 4.0 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.0 | 3.5 | PID PS1 PATHWAY | Presenilin action in Notch and Wnt signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 18.1 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.1 | 17.9 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.1 | 15.3 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.4 | 7.0 | REACTOME FGFR2C LIGAND BINDING AND ACTIVATION | Genes involved in FGFR2c ligand binding and activation |
| 0.0 | 7.0 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 0.1 | 6.1 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.1 | 6.1 | REACTOME IL1 SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.1 | 5.7 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.2 | 5.4 | REACTOME GAP JUNCTION ASSEMBLY | Genes involved in Gap junction assembly |
| 0.1 | 4.0 | REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE | Genes involved in Synthesis of PIPs at the Golgi membrane |