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SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for NFIX_NFIB
Z-value: 2.70
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Transcription factors associated with NFIX_NFIB
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NFIX | hg19_v2_chr19_+_13135790_13135811 | 0.52 | 1.8e-02 | Click! |
| NFIB | hg19_v2_chr9_-_14308004_14308041 | -0.49 | 2.8e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of NFIX_NFIB
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 15.2 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.1 | 15.0 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 1.6 | 14.5 | GO:0001661 | conditioned taste aversion(GO:0001661) |
| 2.9 | 14.4 | GO:0015891 | iron chelate transport(GO:0015688) siderophore transport(GO:0015891) |
| 0.1 | 9.5 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 0.3 | 7.9 | GO:2000404 | regulation of T cell migration(GO:2000404) |
| 0.1 | 6.9 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.1 | 6.7 | GO:0006501 | C-terminal protein lipidation(GO:0006501) |
| 0.3 | 6.3 | GO:0097264 | self proteolysis(GO:0097264) |
| 0.1 | 6.3 | GO:0018149 | peptide cross-linking(GO:0018149) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 67.8 | GO:0031224 | intrinsic component of membrane(GO:0031224) |
| 0.0 | 46.0 | GO:0005615 | extracellular space(GO:0005615) |
| 0.2 | 19.2 | GO:0035580 | specific granule lumen(GO:0035580) |
| 1.7 | 15.3 | GO:0035976 | AP1 complex(GO:0035976) |
| 0.2 | 12.0 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.1 | 11.8 | GO:0005604 | basement membrane(GO:0005604) |
| 0.1 | 10.8 | GO:0035577 | azurophil granule membrane(GO:0035577) |
| 0.1 | 9.0 | GO:0030964 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.5 | 8.5 | GO:0031089 | platelet dense granule lumen(GO:0031089) |
| 0.1 | 8.5 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 29.2 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.1 | 18.6 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.2 | 13.4 | GO:0001102 | RNA polymerase II activating transcription factor binding(GO:0001102) |
| 0.1 | 11.7 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.1 | 9.5 | GO:0008083 | growth factor activity(GO:0008083) |
| 0.0 | 8.9 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.1 | 6.9 | GO:0008137 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.3 | 6.3 | GO:0019841 | retinol binding(GO:0019841) |
| 0.4 | 6.2 | GO:0038062 | protein tyrosine kinase collagen receptor activity(GO:0038062) |
| 0.3 | 6.1 | GO:0036312 | phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 52.5 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 34.8 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 22.9 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.2 | 16.4 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.1 | 15.5 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.4 | 11.9 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.1 | 9.5 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.1 | 6.5 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 0.2 | 6.1 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.1 | 6.1 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 16.3 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.2 | 15.1 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 11.7 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.3 | 9.4 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.1 | 8.9 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.1 | 8.2 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.2 | 6.8 | REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING | Genes involved in Advanced glycosylation endproduct receptor signaling |
| 0.1 | 6.8 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.1 | 6.7 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.1 | 6.4 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |