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SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for NFKB1

Z-value: 1.44

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Transcription factors associated with NFKB1

Gene Symbol Gene ID Gene Info
NFKB1
ENSG00000109320.7 nuclear factor kappa B subunit 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NFKB1hg19_v2_chr4_+_103422499_103422632-0.742.0e-04Click!

Activity profile of NFKB1 motif

Sorted Z-values of NFKB1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr12_+_52445191 12.87 ENST00000243050.1
ENST00000394825.1
ENST00000550763.1
ENST00000394824.2
ENST00000548232.1
ENST00000562373.1
NR4A1
nuclear receptor subfamily 4, group A, member 1
chr4_-_74904398 8.36 ENST00000296026.4
CXCL3
chemokine (C-X-C motif) ligand 3
chr4_-_74964904 7.54 ENST00000508487.2
CXCL2
chemokine (C-X-C motif) ligand 2
chr2_+_228678550 5.94 ENST00000409189.3
ENST00000358813.4
CCL20
chemokine (C-C motif) ligand 20
chr19_-_6591113 5.24 ENST00000423145.3
ENST00000245903.3
CD70
CD70 molecule
chr4_+_74735102 5.04 ENST00000395761.3
CXCL1
chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
chr4_-_74864386 4.51 ENST00000296027.4
CXCL5
chemokine (C-X-C motif) ligand 5
chr12_+_52430894 4.26 ENST00000546842.1
NR4A1
nuclear receptor subfamily 4, group A, member 1
chr1_-_186649543 3.90 ENST00000367468.5
PTGS2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
chr19_+_45504688 3.83 ENST00000221452.8
ENST00000540120.1
ENST00000505236.1
RELB
v-rel avian reticuloendotheliosis viral oncogene homolog B
chr16_+_29823427 3.61 ENST00000358758.7
ENST00000567659.1
ENST00000572820.1
PRRT2
proline-rich transmembrane protein 2
chr1_+_110453203 3.57 ENST00000357302.4
ENST00000344188.5
ENST00000329608.6
CSF1
colony stimulating factor 1 (macrophage)
chr12_-_49259643 3.56 ENST00000309739.5
RND1
Rho family GTPase 1
chr6_-_31550192 3.46 ENST00000429299.2
ENST00000446745.2
LTB
lymphotoxin beta (TNF superfamily, member 3)
chr1_+_6845384 3.45 ENST00000303635.7
CAMTA1
calmodulin binding transcription activator 1
chr10_+_30723105 3.09 ENST00000375322.2
MAP3K8
mitogen-activated protein kinase kinase kinase 8
chr10_+_104154229 3.00 ENST00000428099.1
ENST00000369966.3
NFKB2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
chr6_-_29527702 2.97 ENST00000377050.4
UBD
ubiquitin D
chr12_+_7052974 2.92 ENST00000544681.1
ENST00000537087.1
C12orf57
chromosome 12 open reading frame 57
chr19_-_46145696 2.89 ENST00000588172.1
EML2
echinoderm microtubule associated protein like 2
chr1_+_186649754 2.84 ENST00000608917.1
RP5-973M2.2
RP5-973M2.2
chr14_-_24616426 2.84 ENST00000216802.5
PSME2
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr1_+_37940153 2.82 ENST00000373087.6
ZC3H12A
zinc finger CCCH-type containing 12A
chr1_+_201979743 2.76 ENST00000446188.1
ELF3
E74-like factor 3 (ets domain transcription factor, epithelial-specific )
chr10_+_30723045 2.66 ENST00000542547.1
ENST00000415139.1
MAP3K8
mitogen-activated protein kinase kinase kinase 8
chr14_+_24521202 2.65 ENST00000334420.7
ENST00000342740.5
LRRC16B
leucine rich repeat containing 16B
chr19_-_41222775 2.57 ENST00000324464.3
ENST00000450541.1
ENST00000594720.1
ADCK4
aarF domain containing kinase 4
chr14_-_103589246 2.54 ENST00000558224.1
ENST00000560742.1
LINC00677
long intergenic non-protein coding RNA 677
chr19_+_55795493 2.53 ENST00000309383.1
BRSK1
BR serine/threonine kinase 1
chr10_+_30722866 2.52 ENST00000263056.1
MAP3K8
mitogen-activated protein kinase kinase kinase 8
chr12_+_7053172 2.50 ENST00000229281.5
C12orf57
chromosome 12 open reading frame 57
chr6_-_30080876 2.48 ENST00000376734.3
TRIM31
tripartite motif containing 31
chr1_-_41950342 2.47 ENST00000372587.4
EDN2
endothelin 2
chr6_+_32821924 2.44 ENST00000374859.2
ENST00000453265.2
PSMB9
proteasome (prosome, macropain) subunit, beta type, 9
chr19_+_42364313 2.44 ENST00000601492.1
ENST00000600467.1
ENST00000221975.2
RPS19
ribosomal protein S19
chr19_+_42363917 2.44 ENST00000598742.1
RPS19
ribosomal protein S19
chr6_-_30080863 2.42 ENST00000540829.1
TRIM31
tripartite motif containing 31
chr19_-_38747172 2.40 ENST00000347262.4
ENST00000591585.1
ENST00000301242.4
PPP1R14A
protein phosphatase 1, regulatory (inhibitor) subunit 14A
chr1_+_201979645 2.36 ENST00000367284.5
ENST00000367283.3
ELF3
E74-like factor 3 (ets domain transcription factor, epithelial-specific )
chr2_-_157189180 2.27 ENST00000539077.1
ENST00000424077.1
ENST00000426264.1
ENST00000339562.4
ENST00000421709.1
NR4A2
nuclear receptor subfamily 4, group A, member 2
chr10_-_7708918 2.25 ENST00000256861.6
ENST00000397146.2
ENST00000446830.2
ENST00000397145.2
ITIH5
inter-alpha-trypsin inhibitor heavy chain family, member 5
chr1_+_110453514 2.19 ENST00000369802.3
ENST00000420111.2
CSF1
colony stimulating factor 1 (macrophage)
chr12_-_58131931 2.18 ENST00000547588.1
AGAP2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr17_+_4854375 2.16 ENST00000521811.1
ENST00000519602.1
ENST00000323997.6
ENST00000522249.1
ENST00000519584.1
ENO3
enolase 3 (beta, muscle)
chr19_-_38746979 2.14 ENST00000591291.1
PPP1R14A
protein phosphatase 1, regulatory (inhibitor) subunit 14A
chr6_+_138188351 2.12 ENST00000421450.1
TNFAIP3
tumor necrosis factor, alpha-induced protein 3
chr11_+_560956 2.11 ENST00000397582.3
ENST00000344375.4
ENST00000397583.3
RASSF7
Ras association (RalGDS/AF-6) domain family (N-terminal) member 7
chr11_+_72525353 2.09 ENST00000321297.5
ENST00000534905.1
ENST00000540567.1
ATG16L2
autophagy related 16-like 2 (S. cerevisiae)
chr19_-_46272462 2.08 ENST00000317578.6
SIX5
SIX homeobox 5
chr12_+_7053228 2.07 ENST00000540506.2
C12orf57
chromosome 12 open reading frame 57
chr6_+_29691056 2.05 ENST00000414333.1
ENST00000334668.4
ENST00000259951.7
HLA-F
major histocompatibility complex, class I, F
chr19_+_42364460 2.03 ENST00000593863.1
RPS19
ribosomal protein S19
chr19_+_35485682 2.01 ENST00000599564.1
GRAMD1A
GRAM domain containing 1A
chr19_+_2476116 2.00 ENST00000215631.4
ENST00000587345.1
GADD45B
growth arrest and DNA-damage-inducible, beta
chr14_-_35873856 1.98 ENST00000553342.1
ENST00000216797.5
ENST00000557140.1
NFKBIA
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
chr19_-_4182530 1.98 ENST00000601571.1
ENST00000601488.1
ENST00000305232.6
ENST00000381935.3
ENST00000337491.2
SIRT6
sirtuin 6
chr12_-_62997214 1.96 ENST00000408887.2
C12orf61
chromosome 12 open reading frame 61
chr7_+_69064566 1.96 ENST00000403018.2
AUTS2
autism susceptibility candidate 2
chr1_+_6845497 1.93 ENST00000473578.1
ENST00000557126.1
CAMTA1
calmodulin binding transcription activator 1
chr19_-_47734448 1.91 ENST00000439096.2
BBC3
BCL2 binding component 3
chr11_-_3862206 1.87 ENST00000351018.4
RHOG
ras homolog family member G
chr19_+_48898132 1.85 ENST00000263269.3
GRIN2D
glutamate receptor, ionotropic, N-methyl D-aspartate 2D
chr7_-_100881109 1.82 ENST00000308344.5
CLDN15
claudin 15
chr11_-_66313699 1.82 ENST00000526986.1
ENST00000310442.3
ZDHHC24
zinc finger, DHHC-type containing 24
chr11_+_102188272 1.81 ENST00000532808.1
BIRC3
baculoviral IAP repeat containing 3
chr17_+_7123207 1.80 ENST00000584103.1
ENST00000579886.2
ACADVL
acyl-CoA dehydrogenase, very long chain
chr19_+_40697514 1.76 ENST00000253055.3
MAP3K10
mitogen-activated protein kinase kinase kinase 10
chr9_-_136344197 1.75 ENST00000414172.1
ENST00000371897.4
SLC2A6
solute carrier family 2 (facilitated glucose transporter), member 6
chr19_-_46272106 1.72 ENST00000560168.1
SIX5
SIX homeobox 5
chr12_+_56732658 1.69 ENST00000228534.4
IL23A
interleukin 23, alpha subunit p19
chr6_-_33160231 1.69 ENST00000395194.1
ENST00000457788.1
ENST00000341947.2
ENST00000357486.1
ENST00000374714.1
ENST00000374713.1
ENST00000395197.1
ENST00000374712.1
ENST00000361917.1
ENST00000374708.4
COL11A2
collagen, type XI, alpha 2
chr2_-_177502659 1.68 ENST00000295549.4
AC017048.3
long intergenic non-protein coding RNA 1116
chr16_+_29823552 1.63 ENST00000300797.6
PRRT2
proline-rich transmembrane protein 2
chr17_+_47074758 1.63 ENST00000290341.3
IGF2BP1
insulin-like growth factor 2 mRNA binding protein 1
chr6_+_29691198 1.62 ENST00000440587.2
ENST00000434407.2
HLA-F
major histocompatibility complex, class I, F
chr15_+_76030311 1.59 ENST00000543887.1
AC019294.1
AC019294.1
chr19_+_45251804 1.57 ENST00000164227.5
BCL3
B-cell CLL/lymphoma 3
chr11_+_66059339 1.55 ENST00000327259.4
TMEM151A
transmembrane protein 151A
chr10_+_89419370 1.52 ENST00000361175.4
ENST00000456849.1
PAPSS2
3'-phosphoadenosine 5'-phosphosulfate synthase 2
chr17_+_25799008 1.51 ENST00000583370.1
ENST00000398988.3
ENST00000268763.6
KSR1
kinase suppressor of ras 1
chr19_-_4182497 1.50 ENST00000597896.1
SIRT6
sirtuin 6
chr20_+_44746885 1.47 ENST00000372285.3
CD40
CD40 molecule, TNF receptor superfamily member 5
chr12_+_52431016 1.46 ENST00000553200.1
NR4A1
nuclear receptor subfamily 4, group A, member 1
chr1_+_6845578 1.45 ENST00000467404.2
ENST00000439411.2
CAMTA1
calmodulin binding transcription activator 1
chr1_+_38259540 1.42 ENST00000397631.3
MANEAL
mannosidase, endo-alpha-like
chr5_-_137090028 1.41 ENST00000314940.4
HNRNPA0
heterogeneous nuclear ribonucleoprotein A0
chr17_-_61777090 1.40 ENST00000578061.1
LIMD2
LIM domain containing 2
chr14_+_24439148 1.39 ENST00000543805.1
ENST00000534993.1
DHRS4L2
dehydrogenase/reductase (SDR family) member 4 like 2
chr20_-_2451395 1.35 ENST00000339610.6
ENST00000381342.2
ENST00000438552.2
SNRPB
small nuclear ribonucleoprotein polypeptides B and B1
chr19_+_41860047 1.29 ENST00000604123.1
TMEM91
transmembrane protein 91
chr2_+_97202480 1.29 ENST00000357485.3
ARID5A
AT rich interactive domain 5A (MRF1-like)
chr9_+_134103496 1.28 ENST00000498010.1
ENST00000476004.1
ENST00000528406.1
NUP214
nucleoporin 214kDa
chr7_-_93520191 1.27 ENST00000545378.1
TFPI2
tissue factor pathway inhibitor 2
chr3_+_49058444 1.26 ENST00000326925.6
ENST00000395458.2
NDUFAF3
NADH dehydrogenase (ubiquinone) complex I, assembly factor 3
chr17_+_7590734 1.26 ENST00000457584.2
WRAP53
WD repeat containing, antisense to TP53
chr2_+_38893047 1.21 ENST00000272252.5
GALM
galactose mutarotase (aldose 1-epimerase)
chr12_+_6875519 1.21 ENST00000389462.4
ENST00000540874.1
ENST00000309083.6
PTMS
parathymosin
chr3_+_52280173 1.20 ENST00000296487.4
PPM1M
protein phosphatase, Mg2+/Mn2+ dependent, 1M
chr19_-_17958832 1.19 ENST00000458235.1
JAK3
Janus kinase 3
chr6_+_138188551 1.19 ENST00000237289.4
ENST00000433680.1
TNFAIP3
tumor necrosis factor, alpha-induced protein 3
chr1_-_205904950 1.19 ENST00000340781.4
SLC26A9
solute carrier family 26 (anion exchanger), member 9
chr14_-_24615805 1.18 ENST00000560410.1
PSME2
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr20_+_44746939 1.18 ENST00000372276.3
CD40
CD40 molecule, TNF receptor superfamily member 5
chr1_+_38259459 1.18 ENST00000373045.6
MANEAL
mannosidase, endo-alpha-like
chr8_+_145582217 1.18 ENST00000530047.1
ENST00000527078.1
SLC52A2
solute carrier family 52 (riboflavin transporter), member 2
chr11_+_63997750 1.17 ENST00000321685.3
DNAJC4
DnaJ (Hsp40) homolog, subfamily C, member 4
chr7_-_100881041 1.17 ENST00000412417.1
ENST00000414035.1
CLDN15
claudin 15
chr19_-_46234119 1.16 ENST00000317683.3
FBXO46
F-box protein 46
chr10_+_102756800 1.16 ENST00000370223.3
LZTS2
leucine zipper, putative tumor suppressor 2
chr6_-_32122106 1.15 ENST00000428778.1
PRRT1
proline-rich transmembrane protein 1
chr11_-_6426635 1.15 ENST00000608645.1
ENST00000608394.1
ENST00000529519.1
APBB1
amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
chr2_+_97203082 1.14 ENST00000454558.2
ARID5A
AT rich interactive domain 5A (MRF1-like)
chr17_+_48638371 1.12 ENST00000360761.4
ENST00000352832.5
ENST00000354983.4
CACNA1G
calcium channel, voltage-dependent, T type, alpha 1G subunit
chr17_+_30594823 1.09 ENST00000536287.1
RHBDL3
rhomboid, veinlet-like 3 (Drosophila)
chr8_-_145582118 1.09 ENST00000455319.2
ENST00000331890.5
FBXL6
F-box and leucine-rich repeat protein 6
chr2_+_38893208 1.07 ENST00000410063.1
GALM
galactose mutarotase (aldose 1-epimerase)
chr11_-_64570706 1.07 ENST00000294066.2
ENST00000377350.3
MAP4K2
mitogen-activated protein kinase kinase kinase kinase 2
chr16_+_57126428 1.07 ENST00000290776.8
CPNE2
copine II
chrX_-_100129128 1.06 ENST00000372960.4
ENST00000372964.1
ENST00000217885.5
NOX1
NADPH oxidase 1
chr3_+_52280220 1.05 ENST00000409502.3
ENST00000323588.4
PPM1M
protein phosphatase, Mg2+/Mn2+ dependent, 1M
chr17_+_47075023 1.02 ENST00000431824.2
IGF2BP1
insulin-like growth factor 2 mRNA binding protein 1
chr1_+_169077172 1.02 ENST00000499679.3
ATP1B1
ATPase, Na+/K+ transporting, beta 1 polypeptide
chr17_-_4852332 1.01 ENST00000572383.1
PFN1
profilin 1
chr1_-_8000872 1.01 ENST00000377507.3
TNFRSF9
tumor necrosis factor receptor superfamily, member 9
chr11_+_119056178 1.01 ENST00000525131.1
ENST00000531114.1
ENST00000355547.5
ENST00000322712.4
PDZD3
PDZ domain containing 3
chr19_-_33555780 1.01 ENST00000254260.3
ENST00000400226.4
RHPN2
rhophilin, Rho GTPase binding protein 2
chr19_+_18492973 1.00 ENST00000595973.2
GDF15
growth differentiation factor 15
chr19_-_40324255 1.00 ENST00000593685.1
ENST00000600611.1
DYRK1B
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
chrX_-_100129320 0.99 ENST00000372966.3
NOX1
NADPH oxidase 1
chr17_+_2264983 0.98 ENST00000574650.1
SGSM2
small G protein signaling modulator 2
chr11_-_75062730 0.97 ENST00000420843.2
ENST00000360025.3
ARRB1
arrestin, beta 1
chr8_+_145582231 0.96 ENST00000526338.1
ENST00000402965.1
ENST00000534725.1
ENST00000532887.1
ENST00000329994.2
SLC52A2
solute carrier family 52 (riboflavin transporter), member 2
chr1_+_110453462 0.95 ENST00000488198.1
CSF1
colony stimulating factor 1 (macrophage)
chr7_-_100808394 0.95 ENST00000445482.2
VGF
VGF nerve growth factor inducible
chr19_-_5785630 0.95 ENST00000586012.1
ENST00000590343.1
CTB-54O9.9
DUS3L
Uncharacterized protein
dihydrouridine synthase 3-like (S. cerevisiae)
chr16_+_57126482 0.94 ENST00000537605.1
ENST00000535318.2
CPNE2
copine II
chr7_-_155601766 0.93 ENST00000430104.1
SHH
sonic hedgehog
chr1_-_21978312 0.93 ENST00000359708.4
ENST00000290101.4
RAP1GAP
RAP1 GTPase activating protein
chr11_-_44331679 0.93 ENST00000329255.3
ALX4
ALX homeobox 4
chr11_-_46142948 0.93 ENST00000257821.4
PHF21A
PHD finger protein 21A
chr17_+_40440481 0.92 ENST00000590726.2
ENST00000452307.2
ENST00000444283.1
ENST00000588868.1
STAT5A
signal transducer and activator of transcription 5A
chr17_+_4634705 0.92 ENST00000575284.1
ENST00000573708.1
ENST00000293777.5
MED11
mediator complex subunit 11
chr2_-_217560248 0.92 ENST00000233813.4
IGFBP5
insulin-like growth factor binding protein 5
chr7_-_93520259 0.90 ENST00000222543.5
TFPI2
tissue factor pathway inhibitor 2
chr5_+_159895275 0.90 ENST00000517927.1
MIR146A
microRNA 146a
chr2_-_163175133 0.88 ENST00000421365.2
ENST00000263642.2
IFIH1
interferon induced with helicase C domain 1
chr14_-_64970494 0.88 ENST00000608382.1
ZBTB25
zinc finger and BTB domain containing 25
chr17_-_7154984 0.87 ENST00000574322.1
CTDNEP1
CTD nuclear envelope phosphatase 1
chr19_+_1067271 0.87 ENST00000536472.1
ENST00000590214.1
HMHA1
histocompatibility (minor) HA-1
chr17_-_7123021 0.87 ENST00000399510.2
DLG4
discs, large homolog 4 (Drosophila)
chr15_-_27018884 0.86 ENST00000299267.4
GABRB3
gamma-aminobutyric acid (GABA) A receptor, beta 3
chr11_+_118754475 0.86 ENST00000292174.4
CXCR5
chemokine (C-X-C motif) receptor 5
chr17_-_17740287 0.86 ENST00000355815.4
ENST00000261646.5
SREBF1
sterol regulatory element binding transcription factor 1
chr16_+_67282853 0.86 ENST00000299798.11
SLC9A5
solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5
chr19_+_39390320 0.85 ENST00000576510.1
NFKBIB
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
chr1_+_45274154 0.85 ENST00000450269.1
ENST00000453418.1
ENST00000409335.2
BTBD19
BTB (POZ) domain containing 19
chr19_+_39390587 0.84 ENST00000572515.1
ENST00000392079.3
ENST00000575359.1
ENST00000313582.5
NFKBIB
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
chr6_+_135502466 0.84 ENST00000367814.4
MYB
v-myb avian myeloblastosis viral oncogene homolog
chr11_+_102188224 0.83 ENST00000263464.3
BIRC3
baculoviral IAP repeat containing 3
chr2_+_163175394 0.82 ENST00000446271.1
ENST00000429691.2
GCA
grancalcin, EF-hand calcium binding protein
chr3_-_156878482 0.81 ENST00000295925.4
CCNL1
cyclin L1
chr17_-_39968406 0.80 ENST00000393928.1
LEPREL4
leprecan-like 4
chr5_-_127418573 0.80 ENST00000508353.1
ENST00000508878.1
ENST00000501652.1
ENST00000514409.1
CTC-228N24.3
CTC-228N24.3
chr4_+_185395947 0.80 ENST00000605834.1
RP11-326I11.3
RP11-326I11.3
chr3_-_156878540 0.79 ENST00000461804.1
CCNL1
cyclin L1
chr5_+_170846640 0.79 ENST00000274625.5
FGF18
fibroblast growth factor 18
chr1_+_56880606 0.79 ENST00000451914.1
RP4-710M16.2
RP4-710M16.2
chr11_+_65292538 0.77 ENST00000270176.5
ENST00000525364.1
ENST00000420247.2
ENST00000533862.1
ENST00000279270.6
ENST00000524944.1
SCYL1
SCY1-like 1 (S. cerevisiae)
chr20_-_62462566 0.77 ENST00000245663.4
ENST00000302995.2
ZBTB46
zinc finger and BTB domain containing 46
chr17_+_7123125 0.77 ENST00000356839.5
ENST00000583312.1
ENST00000350303.5
ACADVL
acyl-CoA dehydrogenase, very long chain
chr1_+_185703513 0.77 ENST00000271588.4
ENST00000367492.2
HMCN1
hemicentin 1
chr19_-_39330818 0.76 ENST00000594769.1
ENST00000602021.1
AC104534.3
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial
chr16_-_4303767 0.75 ENST00000573268.1
ENST00000573042.1
RP11-95P2.1
RP11-95P2.1
chr17_-_1420006 0.75 ENST00000320345.6
ENST00000406424.4
INPP5K
inositol polyphosphate-5-phosphatase K
chr8_+_72755796 0.75 ENST00000524152.1
RP11-383H13.1
Protein LOC100132891; cDNA FLJ53548
chr15_-_89438742 0.74 ENST00000562281.1
ENST00000562889.1
ENST00000359595.3
HAPLN3
hyaluronan and proteoglycan link protein 3
chr6_-_32821599 0.73 ENST00000354258.4
TAP1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr10_+_99609996 0.73 ENST00000370602.1
GOLGA7B
golgin A7 family, member B
chr1_+_159796534 0.73 ENST00000289707.5
SLAMF8
SLAM family member 8
chr12_+_49761224 0.73 ENST00000553127.1
ENST00000321898.6
SPATS2
spermatogenesis associated, serine-rich 2
chr19_+_1067144 0.72 ENST00000313093.2
HMHA1
histocompatibility (minor) HA-1
chr10_+_12391481 0.71 ENST00000378847.3
CAMK1D
calcium/calmodulin-dependent protein kinase ID
chr4_-_122085469 0.70 ENST00000057513.3
TNIP3
TNFAIP3 interacting protein 3
chr6_-_31138439 0.70 ENST00000259915.8
POU5F1
POU class 5 homeobox 1
chr4_+_142557717 0.69 ENST00000320650.4
ENST00000296545.7
IL15
interleukin 15
chr17_+_79373540 0.69 ENST00000307745.7
RP11-1055B8.7
BAH and coiled-coil domain-containing protein 1
chr9_-_140115775 0.69 ENST00000391553.1
ENST00000392827.1
RNF208
ring finger protein 208
chr5_-_150460914 0.68 ENST00000389378.2
TNIP1
TNFAIP3 interacting protein 1
chr19_+_39759154 0.67 ENST00000331982.5
IFNL2
interferon, lambda 2
chr6_+_30297306 0.66 ENST00000420746.1
ENST00000513556.1
TRIM39
TRIM39-RPP21
tripartite motif containing 39
TRIM39-RPP21 readthrough
chr1_-_24469602 0.66 ENST00000270800.1
IL22RA1
interleukin 22 receptor, alpha 1
chr5_-_127418755 0.66 ENST00000501702.2
ENST00000501173.2
ENST00000514573.1
ENST00000499346.2
ENST00000606251.1
CTC-228N24.3
CTC-228N24.3
chr19_-_39735646 0.66 ENST00000413851.2
IFNL3
interferon, lambda 3
chr12_-_132905789 0.65 ENST00000328957.8
GALNT9
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 9 (GalNAc-T9)
chr17_-_1420182 0.64 ENST00000421807.2
INPP5K
inositol polyphosphate-5-phosphatase K
chr5_-_67730240 0.63 ENST00000507733.1
CTC-537E7.3
CTC-537E7.3
chrX_-_21776281 0.63 ENST00000379494.3
SMPX
small muscle protein, X-linked
chr2_-_100721178 0.63 ENST00000409236.2
AFF3
AF4/FMR2 family, member 3
chr19_+_1067492 0.63 ENST00000586866.1
HMHA1
histocompatibility (minor) HA-1
chr1_+_221054584 0.62 ENST00000549319.1
HLX
H2.0-like homeobox

Network of associatons between targets according to the STRING database.

First level regulatory network of NFKB1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 5.9 GO:0045362 regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362)
1.7 6.9 GO:0060265 positive regulation of respiratory burst involved in inflammatory response(GO:0060265)
1.6 20.9 GO:0043435 response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
1.5 7.5 GO:0036343 psychomotor behavior(GO:0036343)
1.4 7.1 GO:1903971 mammary gland fat development(GO:0060611) positive regulation of macrophage colony-stimulating factor signaling pathway(GO:1902228) positive regulation of response to macrophage colony-stimulating factor(GO:1903971) positive regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903974) positive regulation of microglial cell migration(GO:1904141)
1.3 3.9 GO:0090271 positive regulation of fibroblast growth factor production(GO:0090271)
1.2 3.5 GO:0003245 cardiac muscle tissue growth involved in heart morphogenesis(GO:0003245) histone H3-K9 deacetylation(GO:1990619)
1.1 4.6 GO:0002268 follicular dendritic cell differentiation(GO:0002268)
1.0 3.1 GO:2000349 regulation of toll-like receptor 5 signaling pathway(GO:0034147) negative regulation of toll-like receptor 5 signaling pathway(GO:0034148) negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070429) tolerance induction to lipopolysaccharide(GO:0072573) negative regulation of CD40 signaling pathway(GO:2000349)
0.9 3.8 GO:1902723 negative regulation of skeletal muscle cell proliferation(GO:0014859) negative regulation of skeletal muscle satellite cell proliferation(GO:1902723)
0.9 2.8 GO:2000625 regulation of miRNA catabolic process(GO:2000625) positive regulation of miRNA catabolic process(GO:2000627)
0.7 2.0 GO:0070427 nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427)
0.6 2.5 GO:0060585 regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.6 2.3 GO:0033499 galactose catabolic process via UDP-galactose(GO:0033499)
0.5 1.6 GO:0045210 negative regulation of dendritic cell cytokine production(GO:0002731) FasL biosynthetic process(GO:0045210)
0.5 14.0 GO:0090023 positive regulation of neutrophil chemotaxis(GO:0090023)
0.5 2.6 GO:0033590 response to cobalamin(GO:0033590)
0.5 2.0 GO:0045726 positive regulation of integrin biosynthetic process(GO:0045726)
0.5 1.5 GO:0045062 extrathymic T cell selection(GO:0045062)
0.4 3.5 GO:0045084 positive regulation of interleukin-12 biosynthetic process(GO:0045084)
0.4 2.1 GO:0032218 riboflavin transport(GO:0032218)
0.4 1.3 GO:0032203 telomere formation via telomerase(GO:0032203)
0.4 3.9 GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480)
0.4 1.1 GO:0050760 negative regulation of thymidylate synthase biosynthetic process(GO:0050760)
0.4 1.5 GO:0000103 sulfate assimilation(GO:0000103)
0.4 6.0 GO:0060056 mammary gland involution(GO:0060056)
0.3 2.1 GO:0039689 negative stranded viral RNA replication(GO:0039689) multi-organism biosynthetic process(GO:0044034)
0.3 1.7 GO:0060023 soft palate development(GO:0060023)
0.3 1.3 GO:0098582 innate vocalization behavior(GO:0098582)
0.3 1.9 GO:2001153 regulation of renal water transport(GO:2001151) positive regulation of renal water transport(GO:2001153)
0.3 0.9 GO:0060738 intein-mediated protein splicing(GO:0016539) protein splicing(GO:0030908) positive regulation of immature T cell proliferation(GO:0033091) positive regulation of immature T cell proliferation in thymus(GO:0033092) right lung development(GO:0060458) primary prostatic bud elongation(GO:0060516) epithelial-mesenchymal signaling involved in prostate gland development(GO:0060738)
0.3 0.9 GO:1903697 negative regulation of microvillus assembly(GO:1903697)
0.3 0.8 GO:1904897 regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922)
0.3 3.0 GO:0070842 aggresome assembly(GO:0070842)
0.3 2.6 GO:0070424 regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070424)
0.3 2.9 GO:0010968 regulation of microtubule nucleation(GO:0010968)
0.2 5.2 GO:0050884 neuromuscular process controlling posture(GO:0050884)
0.2 1.5 GO:0042699 follicle-stimulating hormone signaling pathway(GO:0042699)
0.2 1.0 GO:0034499 late endosome to Golgi transport(GO:0034499)
0.2 0.7 GO:0009786 regulation of asymmetric cell division(GO:0009786)
0.2 0.9 GO:0034343 type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344)
0.2 0.4 GO:0002232 leukocyte chemotaxis involved in inflammatory response(GO:0002232)
0.2 0.6 GO:1904530 negative regulation of actin filament binding(GO:1904530) negative regulation of actin binding(GO:1904617)
0.2 1.0 GO:2001180 negative regulation of interleukin-10 secretion(GO:2001180) negative regulation of interleukin-12 secretion(GO:2001183)
0.2 1.8 GO:0007256 activation of JNKK activity(GO:0007256)
0.2 0.7 GO:0046967 cytosol to ER transport(GO:0046967)
0.2 1.2 GO:1903288 protein transport into plasma membrane raft(GO:0044861) positive regulation of calcium:sodium antiporter activity(GO:1903281) positive regulation of potassium ion import(GO:1903288)
0.2 3.6 GO:0016322 neuron remodeling(GO:0016322)
0.2 1.9 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.2 1.0 GO:0035063 nuclear speck organization(GO:0035063)
0.2 5.2 GO:0046597 negative regulation of viral entry into host cell(GO:0046597)
0.2 1.0 GO:0000255 allantoin metabolic process(GO:0000255)
0.2 2.6 GO:0046322 negative regulation of fatty acid oxidation(GO:0046322)
0.2 0.6 GO:0009386 translational attenuation(GO:0009386)
0.2 0.5 GO:0090330 regulation of platelet aggregation(GO:0090330) negative regulation of platelet aggregation(GO:0090331)
0.2 0.8 GO:0031296 positive regulation of germinal center formation(GO:0002636) B cell costimulation(GO:0031296)
0.1 0.4 GO:1903093 regulation of protein K48-linked deubiquitination(GO:1903093) negative regulation of protein K48-linked deubiquitination(GO:1903094) negative regulation of ubiquitin-specific protease activity(GO:2000157)
0.1 1.6 GO:1901409 positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409)
0.1 0.5 GO:0035262 gonad morphogenesis(GO:0035262)
0.1 9.8 GO:0000186 activation of MAPKK activity(GO:0000186)
0.1 0.8 GO:2000546 positive regulation of cell chemotaxis to fibroblast growth factor(GO:1904849) positive regulation of endothelial cell chemotaxis to fibroblast growth factor(GO:2000546)
0.1 1.0 GO:0086046 membrane depolarization during SA node cell action potential(GO:0086046)
0.1 0.8 GO:2001199 negative regulation of dendritic cell differentiation(GO:2001199)
0.1 0.6 GO:0097039 protein linear polyubiquitination(GO:0097039)
0.1 1.0 GO:0043950 positive regulation of cAMP-mediated signaling(GO:0043950)
0.1 0.7 GO:0051138 positive regulation of NK T cell differentiation(GO:0051138)
0.1 7.9 GO:0050885 neuromuscular process controlling balance(GO:0050885)
0.1 0.9 GO:0002943 tRNA dihydrouridine synthesis(GO:0002943)
0.1 0.3 GO:0021589 hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589)
0.1 0.6 GO:0061086 negative regulation of histone H3-K27 methylation(GO:0061086)
0.1 0.6 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)
0.1 0.2 GO:0045113 regulation of integrin biosynthetic process(GO:0045113)
0.1 1.0 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.1 0.2 GO:0046013 T cell homeostatic proliferation(GO:0001777) regulation of T cell homeostatic proliferation(GO:0046013)
0.1 0.6 GO:0045627 positive regulation of T-helper 1 cell differentiation(GO:0045627)
0.1 2.8 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.1 0.4 GO:0038155 interleukin-23-mediated signaling pathway(GO:0038155)
0.1 1.3 GO:0032688 negative regulation of interferon-beta production(GO:0032688)
0.1 1.7 GO:0010867 positive regulation of triglyceride biosynthetic process(GO:0010867)
0.1 0.2 GO:0003365 establishment of cell polarity involved in ameboidal cell migration(GO:0003365)
0.1 0.3 GO:0060010 Sertoli cell fate commitment(GO:0060010)
0.1 1.4 GO:0070935 3'-UTR-mediated mRNA stabilization(GO:0070935)
0.1 1.2 GO:0019532 oxalate transport(GO:0019532)
0.1 0.2 GO:0071393 cellular response to progesterone stimulus(GO:0071393)
0.1 0.5 GO:0042940 D-amino acid transport(GO:0042940)
0.1 0.2 GO:0031133 regulation of axon diameter(GO:0031133) regulation of adenosine receptor signaling pathway(GO:0060167) positive regulation of adenosine receptor signaling pathway(GO:0060168)
0.1 0.7 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.1 2.2 GO:0071498 cellular response to fluid shear stress(GO:0071498)
0.1 1.9 GO:0051930 regulation of sensory perception of pain(GO:0051930) regulation of sensory perception(GO:0051931)
0.1 0.3 GO:0035105 sterol regulatory element binding protein import into nucleus(GO:0035105)
0.1 0.9 GO:0098719 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.0 0.3 GO:0048619 embryonic hindgut morphogenesis(GO:0048619)
0.0 0.4 GO:0043652 engulfment of apoptotic cell(GO:0043652)
0.0 0.8 GO:0006032 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.0 0.1 GO:0090291 negative regulation of osteoclast proliferation(GO:0090291)
0.0 0.9 GO:0071420 cellular response to histamine(GO:0071420)
0.0 2.2 GO:0043403 skeletal muscle tissue regeneration(GO:0043403)
0.0 0.5 GO:0035897 proteolysis in other organism(GO:0035897)
0.0 1.8 GO:1904659 hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659)
0.0 1.0 GO:1901741 positive regulation of myoblast fusion(GO:1901741)
0.0 4.1 GO:0035690 cellular response to drug(GO:0035690)
0.0 0.6 GO:0097151 positive regulation of inhibitory postsynaptic potential(GO:0097151) modulation of inhibitory postsynaptic potential(GO:0098828)
0.0 1.0 GO:0007520 myoblast fusion(GO:0007520)
0.0 1.9 GO:0090200 positive regulation of release of cytochrome c from mitochondria(GO:0090200)
0.0 1.6 GO:1900027 regulation of ruffle assembly(GO:1900027)
0.0 4.2 GO:0006521 regulation of cellular amino acid metabolic process(GO:0006521)
0.0 2.4 GO:0071391 cellular response to estrogen stimulus(GO:0071391)
0.0 1.8 GO:0071577 zinc II ion transmembrane transport(GO:0071577)
0.0 0.1 GO:1902725 negative regulation of satellite cell differentiation(GO:1902725)
0.0 0.2 GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining(GO:2001034)
0.0 0.6 GO:0001675 acrosome assembly(GO:0001675)
0.0 0.6 GO:0010603 regulation of cytoplasmic mRNA processing body assembly(GO:0010603)
0.0 0.1 GO:0090403 oxidative stress-induced premature senescence(GO:0090403)
0.0 0.4 GO:0098734 macromolecule depalmitoylation(GO:0098734)
0.0 0.4 GO:2000427 positive regulation of apoptotic cell clearance(GO:2000427)
0.0 0.7 GO:2000059 negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000059)
0.0 0.9 GO:0002021 response to dietary excess(GO:0002021)
0.0 0.5 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 0.2 GO:1904668 positive regulation of ubiquitin protein ligase activity(GO:1904668)
0.0 0.3 GO:0060022 hard palate development(GO:0060022)
0.0 1.3 GO:0008334 histone mRNA metabolic process(GO:0008334)
0.0 0.7 GO:0002385 mucosal immune response(GO:0002385)
0.0 0.1 GO:0018057 peptidyl-lysine oxidation(GO:0018057)
0.0 1.9 GO:0071277 cellular response to calcium ion(GO:0071277)
0.0 0.4 GO:0042340 keratan sulfate catabolic process(GO:0042340)
0.0 0.6 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
0.0 0.1 GO:0045196 establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200)
0.0 0.8 GO:0001702 gastrulation with mouth forming second(GO:0001702)
0.0 0.0 GO:0002874 regulation of chronic inflammatory response to antigenic stimulus(GO:0002874)
0.0 0.3 GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter(GO:0032968)
0.0 0.2 GO:0016191 synaptic vesicle uncoating(GO:0016191)
0.0 0.7 GO:0071219 cellular response to molecule of bacterial origin(GO:0071219)
0.0 0.1 GO:1901660 calcium ion export(GO:1901660) calcium ion export from cell(GO:1990034)
0.0 0.2 GO:0035115 embryonic forelimb morphogenesis(GO:0035115)
0.0 0.2 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.0 0.0 GO:0021914 negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021914)
0.0 0.3 GO:0001845 phagolysosome assembly(GO:0001845)
0.0 0.2 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.0 0.7 GO:0006370 7-methylguanosine mRNA capping(GO:0006370)
0.0 0.4 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.0 0.1 GO:2000389 regulation of neutrophil extravasation(GO:2000389)
0.0 0.4 GO:0060334 regulation of interferon-gamma-mediated signaling pathway(GO:0060334)
0.0 1.3 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0 0.9 GO:0042733 embryonic digit morphogenesis(GO:0042733)
0.0 0.3 GO:0031629 synaptic vesicle fusion to presynaptic active zone membrane(GO:0031629) vesicle fusion to plasma membrane(GO:0099500)
0.0 0.1 GO:0034214 protein hexamerization(GO:0034214)
0.0 0.9 GO:0086010 membrane depolarization during action potential(GO:0086010)
0.0 1.1 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0 0.1 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.0 0.9 GO:0070098 chemokine-mediated signaling pathway(GO:0070098)
0.0 2.0 GO:0033209 tumor necrosis factor-mediated signaling pathway(GO:0033209)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 4.6 GO:0033257 Bcl3/NF-kappaB2 complex(GO:0033257)
1.0 7.1 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.9 3.5 GO:0031933 telomeric heterochromatin(GO:0031933)
0.7 4.0 GO:0008537 proteasome activator complex(GO:0008537)
0.4 2.8 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.4 3.9 GO:0042612 MHC class I protein complex(GO:0042612)
0.3 2.6 GO:0043196 varicosity(GO:0043196)
0.3 2.4 GO:1990111 spermatoproteasome complex(GO:1990111)
0.3 1.3 GO:1990876 cytoplasmic side of nuclear pore(GO:1990876)
0.2 2.2 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.1 1.3 GO:0005683 U7 snRNP(GO:0005683)
0.1 0.9 GO:0071595 Nem1-Spo7 phosphatase complex(GO:0071595)
0.1 1.9 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.1 1.3 GO:0016942 insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)
0.1 1.1 GO:1990812 growth cone filopodium(GO:1990812)
0.1 2.0 GO:0071438 invadopodium membrane(GO:0071438)
0.1 1.7 GO:0005583 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1 0.6 GO:0005927 muscle tendon junction(GO:0005927)
0.1 0.7 GO:0042825 TAP complex(GO:0042825)
0.1 0.3 GO:0035101 FACT complex(GO:0035101)
0.1 0.6 GO:0071797 LUBAC complex(GO:0071797)
0.1 6.9 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 0.6 GO:0031501 mannosyltransferase complex(GO:0031501)
0.1 1.1 GO:0098839 postsynaptic density membrane(GO:0098839)
0.1 0.4 GO:0072536 interleukin-23 receptor complex(GO:0072536)
0.1 1.3 GO:0030126 COPI vesicle coat(GO:0030126)
0.1 0.4 GO:0019815 B cell receptor complex(GO:0019815)
0.0 1.2 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0 4.2 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 1.4 GO:0031143 pseudopodium(GO:0031143)
0.0 0.7 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.0 2.1 GO:0000421 autophagosome membrane(GO:0000421)
0.0 0.4 GO:0032584 growth cone membrane(GO:0032584)
0.0 3.0 GO:0016235 aggresome(GO:0016235)
0.0 0.6 GO:0002199 zona pellucida receptor complex(GO:0002199)
0.0 2.4 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 3.8 GO:0005901 caveola(GO:0005901)
0.0 0.7 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.0 0.6 GO:0060077 inhibitory synapse(GO:0060077)
0.0 0.9 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 3.1 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 0.3 GO:0005638 lamin filament(GO:0005638)
0.0 0.2 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.0 1.6 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 11.0 GO:0031965 nuclear membrane(GO:0031965)
0.0 0.6 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 0.9 GO:0016592 mediator complex(GO:0016592)
0.0 0.6 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 1.3 GO:0015030 Cajal body(GO:0015030)
0.0 0.1 GO:0031264 death-inducing signaling complex(GO:0031264) CD95 death-inducing signaling complex(GO:0031265)
0.0 0.5 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 4.5 GO:0000323 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.0 0.3 GO:0033268 node of Ranvier(GO:0033268)
0.0 24.9 GO:0005615 extracellular space(GO:0005615)
0.0 2.9 GO:0008021 synaptic vesicle(GO:0008021)
0.0 0.4 GO:0043204 perikaryon(GO:0043204)
0.0 0.3 GO:0032809 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0 1.8 GO:0032587 ruffle membrane(GO:0032587)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 5.9 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)
1.8 26.5 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
1.2 3.5 GO:0032129 histone deacetylase activity (H3-K9 specific)(GO:0032129) NAD-dependent histone deacetylase activity (H3-K9 specific)(GO:0046969)
0.9 7.1 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
0.8 3.9 GO:0050473 prostaglandin-endoperoxide synthase activity(GO:0004666) arachidonate 15-lipoxygenase activity(GO:0050473)
0.6 4.4 GO:0046979 TAP2 binding(GO:0046979)
0.5 1.5 GO:0004020 adenylylsulfate kinase activity(GO:0004020) sulfate adenylyltransferase activity(GO:0004779) sulfate adenylyltransferase (ATP) activity(GO:0004781)
0.5 2.5 GO:0031708 endothelin B receptor binding(GO:0031708)
0.5 1.5 GO:0031896 V2 vasopressin receptor binding(GO:0031896)
0.4 4.0 GO:0061133 endopeptidase activator activity(GO:0061133)
0.4 1.8 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.4 2.1 GO:0032217 riboflavin transporter activity(GO:0032217)
0.4 1.1 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)
0.3 2.0 GO:0030171 voltage-gated proton channel activity(GO:0030171)
0.3 2.6 GO:0004466 long-chain-acyl-CoA dehydrogenase activity(GO:0004466)
0.3 1.0 GO:0031811 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.2 2.2 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.2 1.2 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.2 1.9 GO:0042577 lipid phosphatase activity(GO:0042577)
0.2 3.0 GO:0008420 CTD phosphatase activity(GO:0008420)
0.2 1.3 GO:0071208 histone pre-mRNA DCP binding(GO:0071208)
0.2 7.8 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.2 0.6 GO:0004584 dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity(GO:0004584)
0.2 6.9 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.2 21.4 GO:0098531 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.2 9.5 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.2 1.0 GO:0004906 interferon-gamma receptor activity(GO:0004906)
0.2 1.7 GO:0030020 extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.2 0.6 GO:0004917 interleukin-7 receptor activity(GO:0004917)
0.1 2.4 GO:0046965 retinoid X receptor binding(GO:0046965)
0.1 1.9 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.1 2.8 GO:0035613 RNA stem-loop binding(GO:0035613)
0.1 0.7 GO:0004904 interferon receptor activity(GO:0004904)
0.1 0.9 GO:0043237 laminin-1 binding(GO:0043237)
0.1 2.3 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.1 1.0 GO:0030249 cyclase regulator activity(GO:0010851) guanylate cyclase regulator activity(GO:0030249)
0.1 2.5 GO:0050321 tau-protein kinase activity(GO:0050321)
0.1 0.9 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.1 1.3 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.1 0.4 GO:0016532 superoxide dismutase copper chaperone activity(GO:0016532)
0.1 3.7 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.1 1.8 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.1 2.4 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1 0.2 GO:0004911 interleukin-2 receptor activity(GO:0004911) interleukin-2 binding(GO:0019976)
0.1 0.7 GO:0001849 complement component C1q binding(GO:0001849)
0.1 1.3 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.1 0.4 GO:0042019 interleukin-23 binding(GO:0042019) interleukin-23 receptor activity(GO:0042020)
0.1 1.0 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.1 0.9 GO:0022851 GABA-gated chloride ion channel activity(GO:0022851)
0.1 2.7 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.1 1.0 GO:0002151 G-quadruplex RNA binding(GO:0002151)
0.1 2.5 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.1 4.9 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.1 1.2 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.1 1.2 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
0.1 0.9 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.1 0.8 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.1 0.9 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
0.1 1.3 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 2.0 GO:0051059 NF-kappaB binding(GO:0051059)
0.0 0.8 GO:0004568 chitinase activity(GO:0004568)
0.0 0.7 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0 1.8 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 3.3 GO:0043621 protein self-association(GO:0043621)
0.0 1.6 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.1 GO:0004727 prenylated protein tyrosine phosphatase activity(GO:0004727)
0.0 0.9 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.6 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 0.7 GO:0035198 miRNA binding(GO:0035198)
0.0 0.1 GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097199)
0.0 0.2 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.0 0.4 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 0.7 GO:0001054 RNA polymerase I activity(GO:0001054) RNA polymerase II activity(GO:0001055)
0.0 0.2 GO:0043532 angiostatin binding(GO:0043532)
0.0 0.3 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.0 4.0 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.8 GO:0070628 proteasome binding(GO:0070628)
0.0 0.5 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 1.0 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.1 GO:0055077 gap junction hemi-channel activity(GO:0055077)
0.0 0.6 GO:0031005 filamin binding(GO:0031005)
0.0 0.2 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.0 0.7 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 0.1 GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580)
0.0 0.5 GO:0071837 HMG box domain binding(GO:0071837)
0.0 0.2 GO:0004800 thyroxine 5'-deiodinase activity(GO:0004800)
0.0 8.9 GO:0003713 transcription coactivator activity(GO:0003713)
0.0 0.1 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.0 0.8 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 3.5 GO:0005125 cytokine activity(GO:0005125)
0.0 2.6 GO:0016798 hydrolase activity, acting on glycosyl bonds(GO:0016798)
0.0 0.1 GO:0004583 dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity(GO:0004583)
0.0 0.1 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.0 0.2 GO:0015250 water channel activity(GO:0015250)
0.0 0.1 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.0 0.0 GO:1904315 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.0 0.9 GO:0001104 RNA polymerase II transcription cofactor activity(GO:0001104)
0.0 0.5 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 1.1 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.0 GO:0036435 K48-linked polyubiquitin binding(GO:0036435)
0.0 0.2 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 1.6 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.3 20.1 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.3 8.3 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.2 7.1 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.2 9.9 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.1 8.3 PID IL23 PATHWAY IL23-mediated signaling events
0.1 1.1 ST JAK STAT PATHWAY Jak-STAT Pathway
0.1 3.3 PID S1P S1P1 PATHWAY S1P1 pathway
0.1 6.4 PID IL12 2PATHWAY IL12-mediated signaling events
0.1 2.5 PID CD40 PATHWAY CD40/CD40L signaling
0.1 2.5 PID LKB1 PATHWAY LKB1 signaling events
0.1 24.8 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 1.5 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.0 1.5 PID NETRIN PATHWAY Netrin-mediated signaling events
0.0 1.3 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 0.7 PID TRAIL PATHWAY TRAIL signaling pathway
0.0 1.5 PID ENDOTHELIN PATHWAY Endothelins
0.0 1.9 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 1.7 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.0 0.8 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.0 1.0 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.0 1.1 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.1 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.0 0.9 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.2 PID NFAT 3PATHWAY Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.0 0.8 PID MYC PATHWAY C-MYC pathway
0.0 1.6 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 0.6 PID CERAMIDE PATHWAY Ceramide signaling pathway
0.0 0.7 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 1.0 PID RAC1 PATHWAY RAC1 signaling pathway
0.0 0.4 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 33.2 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.4 3.9 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.3 8.3 REACTOME CD28 DEPENDENT PI3K AKT SIGNALING Genes involved in CD28 dependent PI3K/Akt signaling
0.2 11.8 REACTOME PIP3 ACTIVATES AKT SIGNALING Genes involved in PIP3 activates AKT signaling
0.2 7.5 REACTOME TRAF6 MEDIATED NFKB ACTIVATION Genes involved in TRAF6 mediated NF-kB activation
0.2 3.6 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.1 2.7 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.1 2.6 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.1 6.9 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1 1.3 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.1 1.2 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.1 1.9 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.1 1.9 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.1 1.8 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.1 5.0 REACTOME ER PHAGOSOME PATHWAY Genes involved in ER-Phagosome pathway
0.1 0.5 REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION Genes involved in activated TAK1 mediates p38 MAPK activation
0.0 1.8 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 1.3 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 1.5 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 2.2 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 0.9 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling
0.0 1.8 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.0 0.5 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 1.0 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 0.6 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 2.2 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 1.3 REACTOME EXTENSION OF TELOMERES Genes involved in Extension of Telomeres
0.0 2.6 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 2.9 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 1.5 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.0 0.7 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.0 1.5 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.9 REACTOME RORA ACTIVATES CIRCADIAN EXPRESSION Genes involved in RORA Activates Circadian Expression
0.0 0.4 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.0 1.2 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.0 1.7 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 1.0 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.0 0.4 REACTOME INITIAL TRIGGERING OF COMPLEMENT Genes involved in Initial triggering of complement
0.0 3.7 REACTOME DIABETES PATHWAYS Genes involved in Diabetes pathways
0.0 2.5 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.6 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 0.5 REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA Genes involved in G beta:gamma signalling through PLC beta
0.0 0.2 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.1 REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10 Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.0 0.9 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.3 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 2.2 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.2 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 0.3 REACTOME ELONGATION ARREST AND RECOVERY Genes involved in Elongation arrest and recovery