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SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for NFKB1
Z-value: 1.44
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Transcription factors associated with NFKB1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NFKB1 | hg19_v2_chr4_+_103422499_103422632 | -0.74 | 2.0e-04 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr12_+_52445191 Show fit | 12.87 |
ENST00000243050.1
ENST00000394825.1 ENST00000550763.1 ENST00000394824.2 ENST00000548232.1 ENST00000562373.1 |
nuclear receptor subfamily 4, group A, member 1 |
|
| chr4_-_74904398 Show fit | 8.36 |
ENST00000296026.4
|
chemokine (C-X-C motif) ligand 3 |
|
| chr4_-_74964904 Show fit | 7.54 |
ENST00000508487.2
|
chemokine (C-X-C motif) ligand 2 |
|
| chr2_+_228678550 Show fit | 5.94 |
ENST00000409189.3
ENST00000358813.4 |
chemokine (C-C motif) ligand 20 |
|
| chr19_-_6591113 Show fit | 5.24 |
ENST00000423145.3
ENST00000245903.3 |
CD70 molecule |
|
| chr4_+_74735102 Show fit | 5.04 |
ENST00000395761.3
|
chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) |
|
| chr4_-_74864386 Show fit | 4.51 |
ENST00000296027.4
|
chemokine (C-X-C motif) ligand 5 |
|
| chr12_+_52430894 Show fit | 4.26 |
ENST00000546842.1
|
nuclear receptor subfamily 4, group A, member 1 |
|
| chr1_-_186649543 Show fit | 3.90 |
ENST00000367468.5
|
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) |
|
| chr19_+_45504688 Show fit | 3.83 |
ENST00000221452.8
ENST00000540120.1 ENST00000505236.1 |
v-rel avian reticuloendotheliosis viral oncogene homolog B |
Network of associatons between targets according to the STRING database.
First level regulatory network of NFKB1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 20.9 | GO:0043435 | response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376) |
| 0.5 | 14.0 | GO:0090023 | positive regulation of neutrophil chemotaxis(GO:0090023) |
| 0.1 | 9.8 | GO:0000186 | activation of MAPKK activity(GO:0000186) |
| 0.1 | 7.9 | GO:0050885 | neuromuscular process controlling balance(GO:0050885) |
| 1.5 | 7.5 | GO:0036343 | psychomotor behavior(GO:0036343) |
| 1.4 | 7.1 | GO:1903971 | mammary gland fat development(GO:0060611) positive regulation of macrophage colony-stimulating factor signaling pathway(GO:1902228) positive regulation of response to macrophage colony-stimulating factor(GO:1903971) positive regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903974) positive regulation of microglial cell migration(GO:1904141) |
| 1.7 | 6.9 | GO:0060265 | positive regulation of respiratory burst involved in inflammatory response(GO:0060265) |
| 0.4 | 6.0 | GO:0060056 | mammary gland involution(GO:0060056) |
| 2.0 | 5.9 | GO:0045362 | regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362) |
| 0.2 | 5.2 | GO:0050884 | neuromuscular process controlling posture(GO:0050884) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 24.9 | GO:0005615 | extracellular space(GO:0005615) |
| 0.0 | 11.0 | GO:0031965 | nuclear membrane(GO:0031965) |
| 1.0 | 7.1 | GO:1990682 | CSF1-CSF1R complex(GO:1990682) |
| 0.1 | 6.9 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 1.1 | 4.6 | GO:0033257 | Bcl3/NF-kappaB2 complex(GO:0033257) |
| 0.0 | 4.5 | GO:0000323 | lytic vacuole(GO:0000323) lysosome(GO:0005764) |
| 0.0 | 4.2 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.7 | 4.0 | GO:0008537 | proteasome activator complex(GO:0008537) |
| 0.4 | 3.9 | GO:0042612 | MHC class I protein complex(GO:0042612) |
| 0.0 | 3.8 | GO:0005901 | caveola(GO:0005901) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 26.5 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 0.2 | 21.4 | GO:0098531 | RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531) |
| 0.2 | 9.5 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.0 | 8.9 | GO:0003713 | transcription coactivator activity(GO:0003713) |
| 0.2 | 7.8 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.9 | 7.1 | GO:0005157 | macrophage colony-stimulating factor receptor binding(GO:0005157) |
| 0.2 | 6.9 | GO:0017134 | fibroblast growth factor binding(GO:0017134) |
| 2.0 | 5.9 | GO:0031731 | CCR6 chemokine receptor binding(GO:0031731) |
| 0.1 | 4.9 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
| 0.6 | 4.4 | GO:0046979 | TAP2 binding(GO:0046979) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 24.8 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.3 | 20.1 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.2 | 9.9 | ST TUMOR NECROSIS FACTOR PATHWAY | Tumor Necrosis Factor Pathway. |
| 0.3 | 8.3 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.1 | 8.3 | PID IL23 PATHWAY | IL23-mediated signaling events |
| 0.2 | 7.1 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.1 | 6.4 | PID IL12 2PATHWAY | IL12-mediated signaling events |
| 0.1 | 3.3 | PID S1P S1P1 PATHWAY | S1P1 pathway |
| 0.1 | 2.5 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 0.1 | 2.5 | PID LKB1 PATHWAY | LKB1 signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 33.2 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.2 | 11.8 | REACTOME PIP3 ACTIVATES AKT SIGNALING | Genes involved in PIP3 activates AKT signaling |
| 0.3 | 8.3 | REACTOME CD28 DEPENDENT PI3K AKT SIGNALING | Genes involved in CD28 dependent PI3K/Akt signaling |
| 0.2 | 7.5 | REACTOME TRAF6 MEDIATED NFKB ACTIVATION | Genes involved in TRAF6 mediated NF-kB activation |
| 0.1 | 6.9 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.1 | 5.0 | REACTOME ER PHAGOSOME PATHWAY | Genes involved in ER-Phagosome pathway |
| 0.4 | 3.9 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 0.0 | 3.7 | REACTOME DIABETES PATHWAYS | Genes involved in Diabetes pathways |
| 0.2 | 3.6 | REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.0 | 2.9 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |