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SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for NKX1-1

Z-value: 0.40

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Transcription factors associated with NKX1-1

Gene Symbol Gene ID Gene Info
NKX1-1
ENSG00000235608.1 NK1 homeobox 1

Activity profile of NKX1-1 motif

Sorted Z-values of NKX1-1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_+_8822113 1.54 ENST00000396290.1
ENST00000331129.3
ID2
inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
chr1_-_197115818 1.21 ENST00000367409.4
ENST00000294732.7
ASPM
asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
chr17_+_57233087 0.86 ENST00000578777.1
ENST00000577457.1
ENST00000582995.1
PRR11
proline rich 11
chr12_+_102513950 0.75 ENST00000378128.3
ENST00000327680.2
ENST00000541394.1
ENST00000543784.1
PARPBP
PARP1 binding protein
chr7_-_27239703 0.67 ENST00000222753.4
HOXA13
homeobox A13
chr17_+_57232690 0.67 ENST00000262293.4
PRR11
proline rich 11
chr8_+_26371763 0.66 ENST00000521913.1
DPYSL2
dihydropyrimidinase-like 2
chr17_-_45266542 0.62 ENST00000531206.1
ENST00000527547.1
ENST00000446365.2
ENST00000575483.1
ENST00000066544.3
CDC27
cell division cycle 27
chr12_+_102514019 0.61 ENST00000537257.1
ENST00000358383.5
ENST00000392911.2
PARPBP
PARP1 binding protein
chr4_-_89442940 0.59 ENST00000527353.1
PIGY
phosphatidylinositol glycan anchor biosynthesis, class Y
chr17_-_8113886 0.56 ENST00000577833.1
ENST00000534871.1
ENST00000583915.1
ENST00000316199.6
ENST00000581511.1
ENST00000585124.1
AURKB
aurora kinase B
chr9_+_116225999 0.54 ENST00000317613.6
RGS3
regulator of G-protein signaling 3
chr19_+_32897009 0.53 ENST00000342179.5
ENST00000586427.1
DPY19L3
dpy-19-like 3 (C. elegans)
chr7_-_73256838 0.49 ENST00000297873.4
WBSCR27
Williams Beuren syndrome chromosome region 27
chr7_-_86849883 0.48 ENST00000433078.1
TMEM243
transmembrane protein 243, mitochondrial
chr7_+_26331541 0.48 ENST00000416246.1
ENST00000338523.4
ENST00000412416.1
SNX10
sorting nexin 10
chr12_+_64798826 0.43 ENST00000540203.1
XPOT
exportin, tRNA
chrX_+_72783026 0.40 ENST00000373504.6
ENST00000373502.5
CHIC1
cysteine-rich hydrophobic domain 1
chr14_-_81425828 0.40 ENST00000555529.1
ENST00000556042.1
ENST00000556981.1
CEP128
centrosomal protein 128kDa
chr6_-_85473073 0.40 ENST00000606621.1
TBX18
T-box 18
chr10_-_1094819 0.39 ENST00000429642.1
IDI1
isopentenyl-diphosphate delta isomerase 1
chr19_+_32896697 0.39 ENST00000586987.1
DPY19L3
dpy-19-like 3 (C. elegans)
chr12_+_16500037 0.39 ENST00000536371.1
ENST00000010404.2
MGST1
microsomal glutathione S-transferase 1
chr6_-_82957433 0.33 ENST00000306270.7
IBTK
inhibitor of Bruton agammaglobulinemia tyrosine kinase
chr1_-_21620877 0.32 ENST00000527991.1
ECE1
endothelin converting enzyme 1
chr16_-_66864806 0.32 ENST00000566336.1
ENST00000394074.2
ENST00000563185.2
ENST00000359087.4
ENST00000379463.2
ENST00000565535.1
ENST00000290810.3
NAE1
NEDD8 activating enzyme E1 subunit 1
chr7_+_12727250 0.31 ENST00000404894.1
ARL4A
ADP-ribosylation factor-like 4A
chr1_-_159832438 0.31 ENST00000368100.1
VSIG8
V-set and immunoglobulin domain containing 8
chr12_+_28410128 0.30 ENST00000381259.1
ENST00000381256.1
CCDC91
coiled-coil domain containing 91
chr7_+_26331678 0.29 ENST00000446848.2
SNX10
sorting nexin 10
chr1_+_100818009 0.28 ENST00000370125.2
ENST00000361544.6
ENST00000370124.3
CDC14A
cell division cycle 14A
chr12_-_102513843 0.27 ENST00000551744.2
ENST00000552283.1
NUP37
nucleoporin 37kDa
chr1_-_151762943 0.26 ENST00000368825.3
ENST00000368823.1
ENST00000458431.2
ENST00000368827.6
ENST00000368824.3
TDRKH
tudor and KH domain containing
chr2_-_167232484 0.26 ENST00000375387.4
ENST00000303354.6
ENST00000409672.1
SCN9A
sodium channel, voltage-gated, type IX, alpha subunit
chr7_-_99716940 0.26 ENST00000440225.1
TAF6
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr17_-_57232596 0.25 ENST00000581068.1
ENST00000330137.7
SKA2
spindle and kinetochore associated complex subunit 2
chr15_-_78526942 0.25 ENST00000258873.4
ACSBG1
acyl-CoA synthetase bubblegum family member 1
chr12_+_16500599 0.25 ENST00000535309.1
ENST00000540056.1
ENST00000396209.1
ENST00000540126.1
MGST1
microsomal glutathione S-transferase 1
chr1_-_151762900 0.24 ENST00000440583.2
TDRKH
tudor and KH domain containing
chr17_-_57232525 0.24 ENST00000583380.1
ENST00000580541.1
ENST00000578105.1
ENST00000437036.2
SKA2
spindle and kinetochore associated complex subunit 2
chrX_-_47509994 0.24 ENST00000343894.4
ELK1
ELK1, member of ETS oncogene family
chr13_+_36050881 0.23 ENST00000537702.1
NBEA
neurobeachin
chr13_+_78315295 0.22 ENST00000351546.3
SLAIN1
SLAIN motif family, member 1
chr11_+_72983246 0.22 ENST00000393590.2
P2RY6
pyrimidinergic receptor P2Y, G-protein coupled, 6
chr11_-_105892937 0.21 ENST00000301919.4
ENST00000534458.1
ENST00000530108.1
ENST00000530788.1
MSANTD4
Myb/SANT-like DNA-binding domain containing 4 with coiled-coils
chr12_+_16500571 0.21 ENST00000543076.1
ENST00000396210.3
MGST1
microsomal glutathione S-transferase 1
chr12_-_6961050 0.21 ENST00000538862.2
CDCA3
cell division cycle associated 3
chr7_-_33102399 0.20 ENST00000242210.7
NT5C3A
5'-nucleotidase, cytosolic IIIA
chr15_-_64386120 0.20 ENST00000300030.3
FAM96A
family with sequence similarity 96, member A
chr11_-_4629367 0.19 ENST00000533021.1
TRIM68
tripartite motif containing 68
chr2_-_97405775 0.19 ENST00000264963.4
ENST00000537039.1
ENST00000377079.4
ENST00000426463.2
ENST00000534882.1
LMAN2L
lectin, mannose-binding 2-like
chr7_-_33102338 0.19 ENST00000610140.1
NT5C3A
5'-nucleotidase, cytosolic IIIA
chr1_+_161691353 0.18 ENST00000367948.2
FCRLB
Fc receptor-like B
chr2_-_47142884 0.17 ENST00000409105.1
ENST00000409973.1
ENST00000409913.1
ENST00000319466.4
MCFD2
multiple coagulation factor deficiency 2
chr2_-_47143160 0.17 ENST00000409800.1
ENST00000409218.1
MCFD2
multiple coagulation factor deficiency 2
chr8_+_98656693 0.17 ENST00000519934.1
MTDH
metadherin
chr1_+_240255166 0.16 ENST00000319653.9
FMN2
formin 2
chr11_-_124981475 0.15 ENST00000532156.1
ENST00000532407.1
ENST00000279968.4
ENST00000527766.1
ENST00000529583.1
ENST00000524373.1
ENST00000527271.1
ENST00000526175.1
ENST00000529609.1
ENST00000533273.1
ENST00000531909.1
ENST00000529530.1
TMEM218
transmembrane protein 218
chr19_+_36249057 0.15 ENST00000301165.5
ENST00000536950.1
ENST00000537459.1
ENST00000421853.2
C19orf55
chromosome 19 open reading frame 55
chr1_+_46972668 0.15 ENST00000371956.4
ENST00000360032.3
DMBX1
diencephalon/mesencephalon homeobox 1
chr1_+_100818156 0.15 ENST00000336454.3
CDC14A
cell division cycle 14A
chr19_+_36249044 0.14 ENST00000444637.2
ENST00000396908.4
ENST00000544099.1
C19orf55
chromosome 19 open reading frame 55
chr8_+_98656336 0.14 ENST00000336273.3
MTDH
metadherin
chr1_-_231004220 0.14 ENST00000366663.5
C1orf198
chromosome 1 open reading frame 198
chr10_-_1095050 0.13 ENST00000381344.3
IDI1
isopentenyl-diphosphate delta isomerase 1
chr3_+_23851928 0.13 ENST00000467766.1
ENST00000424381.1
UBE2E1
ubiquitin-conjugating enzyme E2E 1
chr6_+_34204642 0.13 ENST00000347617.6
ENST00000401473.3
ENST00000311487.5
ENST00000447654.1
ENST00000395004.3
HMGA1
high mobility group AT-hook 1
chr18_-_33709268 0.13 ENST00000269187.5
ENST00000590986.1
ENST00000440549.2
SLC39A6
solute carrier family 39 (zinc transporter), member 6
chr7_+_6048856 0.13 ENST00000223029.3
ENST00000400479.2
ENST00000395236.2
AIMP2
aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
chr13_+_78315348 0.11 ENST00000441784.1
SLAIN1
SLAIN motif family, member 1
chr2_+_187371440 0.11 ENST00000445547.1
ZC3H15
zinc finger CCCH-type containing 15
chr11_-_4629388 0.11 ENST00000526337.1
ENST00000300747.5
TRIM68
tripartite motif containing 68
chr10_-_99205607 0.10 ENST00000477692.2
ENST00000485122.2
ENST00000370886.5
ENST00000370885.4
ENST00000370902.3
ENST00000370884.5
EXOSC1
exosome component 1
chr3_+_57261743 0.10 ENST00000288266.3
APPL1
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
chr7_-_86849836 0.10 ENST00000455575.1
TMEM243
transmembrane protein 243, mitochondrial
chr10_+_5238793 0.10 ENST00000263126.1
AKR1C4
aldo-keto reductase family 1, member C4
chr15_-_78526855 0.10 ENST00000541759.1
ENST00000558130.1
ACSBG1
acyl-CoA synthetase bubblegum family member 1
chr12_-_117175819 0.09 ENST00000261318.3
ENST00000536380.1
C12orf49
chromosome 12 open reading frame 49
chr9_+_139780942 0.09 ENST00000247668.2
ENST00000359662.3
TRAF2
TNF receptor-associated factor 2
chr5_-_159546396 0.09 ENST00000523662.1
ENST00000456329.3
ENST00000307063.7
PWWP2A
PWWP domain containing 2A
chr1_+_62439037 0.09 ENST00000545929.1
INADL
InaD-like (Drosophila)
chr7_-_99716952 0.09 ENST00000523306.1
ENST00000344095.4
ENST00000417349.1
ENST00000493322.1
ENST00000520135.1
ENST00000418432.2
ENST00000460673.2
ENST00000452041.1
ENST00000452438.2
ENST00000451699.1
ENST00000453269.2
TAF6
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr1_-_108507631 0.08 ENST00000527011.1
ENST00000370056.4
VAV3
vav 3 guanine nucleotide exchange factor
chr15_+_96904487 0.08 ENST00000600790.1
AC087477.1
Uncharacterized protein
chr17_-_40337470 0.08 ENST00000293330.1
HCRT
hypocretin (orexin) neuropeptide precursor
chr12_+_7013897 0.07 ENST00000007969.8
ENST00000323702.5
LRRC23
leucine rich repeat containing 23
chr12_+_7014126 0.06 ENST00000415834.1
ENST00000436789.1
LRRC23
leucine rich repeat containing 23
chr15_-_64385981 0.06 ENST00000557835.1
ENST00000380290.3
ENST00000559950.1
FAM96A
family with sequence similarity 96, member A
chr4_-_66536196 0.06 ENST00000511294.1
EPHA5
EPH receptor A5
chr17_-_44439084 0.06 ENST00000575960.1
ENST00000575698.1
ENST00000571246.1
ENST00000434041.2
ENST00000570618.1
ENST00000450673.3
ARL17B
ADP-ribosylation factor-like 17B
chr11_+_119205222 0.05 ENST00000311413.4
RNF26
ring finger protein 26
chr1_-_190446759 0.05 ENST00000367462.3
BRINP3
bone morphogenetic protein/retinoic acid inducible neural-specific 3
chr17_-_44657017 0.05 ENST00000573185.1
ENST00000570550.1
ENST00000445552.2
ENST00000336125.5
ENST00000329240.4
ENST00000337845.7
ARL17A
ADP-ribosylation factor-like 17A
chr16_-_11036300 0.04 ENST00000331808.4
DEXI
Dexi homolog (mouse)
chr4_-_66536057 0.04 ENST00000273854.3
EPHA5
EPH receptor A5
chr18_-_44181442 0.04 ENST00000398722.4
LOXHD1
lipoxygenase homology domains 1
chr4_+_66536248 0.04 ENST00000514260.1
ENST00000507117.1
RP11-807H7.1
RP11-807H7.1
chr4_+_87515454 0.04 ENST00000427191.2
ENST00000436978.1
ENST00000502971.1
PTPN13
protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
chr7_-_99717463 0.03 ENST00000437822.2
TAF6
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr12_+_7014064 0.02 ENST00000443597.2
LRRC23
leucine rich repeat containing 23
chr7_+_120628731 0.02 ENST00000310396.5
CPED1
cadherin-like and PC-esterase domain containing 1
chr1_+_222910625 0.02 ENST00000360827.2
FAM177B
family with sequence similarity 177, member B
chr18_+_63273310 0.01 ENST00000579862.1
RP11-775G23.1
RP11-775G23.1
chrX_+_55026763 0.01 ENST00000374987.3
APEX2
APEX nuclease (apurinic/apyrimidinic endonuclease) 2
chr2_-_239197238 0.01 ENST00000254657.3
PER2
period circadian clock 2
chr10_+_120789223 0.01 ENST00000425699.1
NANOS1
nanos homolog 1 (Drosophila)
chr19_+_45504688 0.01 ENST00000221452.8
ENST00000540120.1
ENST00000505236.1
RELB
v-rel avian reticuloendotheliosis viral oncogene homolog B
chr19_+_39930212 0.01 ENST00000396843.1
AC011500.1
Interleukin-like; Uncharacterized protein
chr22_+_17956618 0.01 ENST00000262608.8
CECR2
cat eye syndrome chromosome region, candidate 2
chr3_+_158519654 0.01 ENST00000415822.2
ENST00000392813.4
ENST00000264266.8
MFSD1
major facilitator superfamily domain containing 1
chr16_-_2318055 0.00 ENST00000561518.1
ENST00000561718.1
ENST00000567147.1
ENST00000562690.1
ENST00000569598.2
RNPS1
RNA binding protein S1, serine-rich domain

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX1-1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0009786 regulation of asymmetric cell division(GO:0009786)
0.3 1.5 GO:0061030 epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.3 0.8 GO:0071449 cellular response to lipid hydroperoxide(GO:0071449)
0.1 0.4 GO:0060829 regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060827) negative regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060829)
0.1 0.5 GO:0050993 dimethylallyl diphosphate biosynthetic process(GO:0050992) dimethylallyl diphosphate metabolic process(GO:0050993)
0.1 1.4 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.1 0.6 GO:0043988 histone H3-S28 phosphorylation(GO:0043988)
0.1 0.9 GO:0018211 protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.1 0.2 GO:0051758 homologous chromosome movement towards spindle pole involved in homologous chromosome segregation(GO:0051758)
0.1 0.3 GO:0034959 substance P catabolic process(GO:0010814) calcitonin catabolic process(GO:0010816) endothelin maturation(GO:0034959)
0.0 0.1 GO:1903630 regulation of aminoacyl-tRNA ligase activity(GO:1903630)
0.0 0.1 GO:0090402 oncogene-induced cell senescence(GO:0090402)
0.0 0.4 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.0 0.3 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.0 0.4 GO:0046085 adenosine metabolic process(GO:0046085)
0.0 0.1 GO:1903719 regulation of I-kappaB phosphorylation(GO:1903719) positive regulation of I-kappaB phosphorylation(GO:1903721)
0.0 0.8 GO:0071539 protein localization to centrosome(GO:0071539)
0.0 0.3 GO:0090160 Golgi to lysosome transport(GO:0090160)
0.0 0.2 GO:0071394 cellular response to testosterone stimulus(GO:0071394)
0.0 0.1 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.0 0.3 GO:0034587 piRNA metabolic process(GO:0034587)
0.0 0.2 GO:0008343 adult feeding behavior(GO:0008343)
0.0 0.1 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.0 0.2 GO:0030321 transepithelial chloride transport(GO:0030321)
0.0 0.1 GO:0071395 response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395)
0.0 0.7 GO:0071431 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.0 0.7 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 0.6 GO:0006506 GPI anchor biosynthetic process(GO:0006506)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0071547 piP-body(GO:0071547)
0.1 1.2 GO:0072687 meiotic spindle(GO:0072687)
0.1 0.6 GO:0032133 chromosome passenger complex(GO:0032133)
0.1 0.8 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.1 0.3 GO:0031302 intrinsic component of endosome membrane(GO:0031302)
0.0 0.6 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0 0.4 GO:0060091 kinocilium(GO:0060091)
0.0 0.1 GO:0097057 TRAF2-GSTP1 complex(GO:0097057)
0.0 0.5 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 0.3 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 0.3 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 0.5 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.1 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.0 0.2 GO:0001518 voltage-gated sodium channel complex(GO:0001518)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.1 0.5 GO:0004452 isopentenyl-diphosphate delta-isomerase activity(GO:0004452)
0.1 0.3 GO:0019781 NEDD8 activating enzyme activity(GO:0019781)
0.1 0.4 GO:0008665 2'-phosphotransferase activity(GO:0008665)
0.1 0.3 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.1 0.6 GO:0035174 histone serine kinase activity(GO:0035174)
0.0 0.8 GO:0043295 glutathione binding(GO:0043295)
0.0 0.1 GO:0005174 CD40 receptor binding(GO:0005174)
0.0 0.8 GO:0000030 mannosyltransferase activity(GO:0000030)
0.0 0.2 GO:0045029 UDP-activated nucleotide receptor activity(GO:0045029)
0.0 0.1 GO:0047023 androsterone dehydrogenase activity(GO:0047023)
0.0 0.8 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 0.3 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 0.3 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0 0.1 GO:0042296 ISG15 transferase activity(GO:0042296)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 ST PHOSPHOINOSITIDE 3 KINASE PATHWAY PI3K Pathway
0.0 1.5 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.2 REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0 0.8 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 0.7 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.1 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection