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SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for NKX1-2_RAX

Z-value: 1.38

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Transcription factors associated with NKX1-2_RAX

Gene Symbol Gene ID Gene Info
NKX1-2
ENSG00000229544.6 NK1 homeobox 2
RAX
ENSG00000134438.9 retina and anterior neural fold homeobox

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NKX1-2hg19_v2_chr10_-_126138622_1261387530.982.5e-13Click!
RAXhg19_v2_chr18_-_56940611_56940660-0.445.0e-02Click!

Activity profile of NKX1-2_RAX motif

Sorted Z-values of NKX1-2_RAX motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_-_151034734 13.49 ENST00000260843.4
GPR87
G protein-coupled receptor 87
chr1_-_159915386 7.32 ENST00000361509.3
ENST00000368094.1
IGSF9
immunoglobulin superfamily, member 9
chr10_-_105845674 6.20 ENST00000353479.5
ENST00000369733.3
COL17A1
collagen, type XVII, alpha 1
chr4_-_74486217 5.45 ENST00000335049.5
ENST00000307439.5
RASSF6
Ras association (RalGDS/AF-6) domain family member 6
chr10_-_105845536 5.23 ENST00000393211.3
COL17A1
collagen, type XVII, alpha 1
chr5_+_66300464 5.22 ENST00000436277.1
MAST4
microtubule associated serine/threonine kinase family member 4
chr4_-_74486347 4.74 ENST00000342081.3
RASSF6
Ras association (RalGDS/AF-6) domain family member 6
chr11_-_13011081 4.66 ENST00000532541.1
ENST00000526388.1
ENST00000534477.1
ENST00000531402.1
ENST00000527945.1
ENST00000504230.2
LINC00958
long intergenic non-protein coding RNA 958
chr4_-_74486109 4.52 ENST00000395777.2
RASSF6
Ras association (RalGDS/AF-6) domain family member 6
chr3_-_105587879 4.50 ENST00000264122.4
ENST00000403724.1
ENST00000405772.1
CBLB
Cbl proto-oncogene B, E3 ubiquitin protein ligase
chr5_+_66300446 4.25 ENST00000261569.7
MAST4
microtubule associated serine/threonine kinase family member 4
chr6_+_130339710 4.07 ENST00000526087.1
ENST00000533560.1
ENST00000361794.2
L3MBTL3
l(3)mbt-like 3 (Drosophila)
chr17_-_39216344 3.71 ENST00000391418.2
KRTAP2-3
keratin associated protein 2-3
chr2_-_74618907 3.58 ENST00000421392.1
ENST00000437375.1
DCTN1
dynactin 1
chr3_+_195447738 3.48 ENST00000447234.2
ENST00000320736.6
ENST00000436408.1
MUC20
mucin 20, cell surface associated
chrX_+_43515467 3.29 ENST00000338702.3
ENST00000542639.1
MAOA
monoamine oxidase A
chr19_-_36822551 3.24 ENST00000591372.1
LINC00665
long intergenic non-protein coding RNA 665
chr3_-_105588231 3.23 ENST00000545639.1
ENST00000394027.3
ENST00000438603.1
ENST00000447441.1
ENST00000443752.1
CBLB
Cbl proto-oncogene B, E3 ubiquitin protein ligase
chr11_+_5710919 3.07 ENST00000379965.3
ENST00000425490.1
TRIM22
tripartite motif containing 22
chr2_+_210518057 3.01 ENST00000452717.1
MAP2
microtubule-associated protein 2
chr11_-_59383617 2.98 ENST00000263847.1
OSBP
oxysterol binding protein
chr9_+_124329336 2.95 ENST00000394340.3
ENST00000436835.1
ENST00000259371.2
DAB2IP
DAB2 interacting protein
chr2_+_210517895 2.87 ENST00000447185.1
MAP2
microtubule-associated protein 2
chr4_+_26324474 2.64 ENST00000514675.1
RBPJ
recombination signal binding protein for immunoglobulin kappa J region
chr19_+_11071546 2.61 ENST00000358026.2
SMARCA4
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
chr11_+_71900703 2.55 ENST00000393681.2
FOLR1
folate receptor 1 (adult)
chr1_+_160370344 2.46 ENST00000368061.2
VANGL2
VANGL planar cell polarity protein 2
chrX_+_135618258 2.39 ENST00000440515.1
ENST00000456412.1
VGLL1
vestigial like 1 (Drosophila)
chr20_-_50722183 2.37 ENST00000371523.4
ZFP64
ZFP64 zinc finger protein
chr8_-_37351424 2.37 ENST00000522718.1
RP11-150O12.1
RP11-150O12.1
chr11_+_71900572 2.37 ENST00000312293.4
FOLR1
folate receptor 1 (adult)
chr10_+_99205894 2.27 ENST00000370854.3
ENST00000393760.1
ENST00000414567.1
ENST00000370846.4
ZDHHC16
zinc finger, DHHC-type containing 16
chr6_+_26440700 2.24 ENST00000494393.1
ENST00000482451.1
ENST00000244519.2
ENST00000339789.4
ENST00000471353.1
ENST00000361232.3
ENST00000487627.1
ENST00000496719.1
ENST00000490254.1
ENST00000487272.1
BTN3A3
butyrophilin, subfamily 3, member A3
chr2_+_191221240 2.15 ENST00000409027.1
ENST00000458193.1
INPP1
inositol polyphosphate-1-phosphatase
chr3_+_158519654 2.12 ENST00000415822.2
ENST00000392813.4
ENST00000264266.8
MFSD1
major facilitator superfamily domain containing 1
chr14_-_88200641 2.00 ENST00000556168.1
RP11-1152H15.1
RP11-1152H15.1
chr4_-_25865159 1.95 ENST00000502949.1
ENST00000264868.5
ENST00000513691.1
ENST00000514872.1
SEL1L3
sel-1 suppressor of lin-12-like 3 (C. elegans)
chr17_+_1666108 1.94 ENST00000570731.1
SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr19_-_36001113 1.89 ENST00000434389.1
DMKN
dermokine
chr19_-_36822595 1.87 ENST00000585356.1
ENST00000438368.2
ENST00000590622.1
LINC00665
long intergenic non-protein coding RNA 665
chr15_+_93447675 1.79 ENST00000536619.1
CHD2
chromodomain helicase DNA binding protein 2
chr11_-_102651343 1.76 ENST00000279441.4
ENST00000539681.1
MMP10
matrix metallopeptidase 10 (stromelysin 2)
chr17_-_57232525 1.67 ENST00000583380.1
ENST00000580541.1
ENST00000578105.1
ENST00000437036.2
SKA2
spindle and kinetochore associated complex subunit 2
chr15_+_93443419 1.62 ENST00000557381.1
ENST00000420239.2
CHD2
chromodomain helicase DNA binding protein 2
chr17_+_57233087 1.62 ENST00000578777.1
ENST00000577457.1
ENST00000582995.1
PRR11
proline rich 11
chr10_+_99205959 1.60 ENST00000352634.4
ENST00000353979.3
ENST00000370842.2
ENST00000345745.5
ZDHHC16
zinc finger, DHHC-type containing 16
chr9_+_135937365 1.52 ENST00000372080.4
ENST00000351304.7
CEL
carboxyl ester lipase
chr5_-_102898465 1.52 ENST00000507423.1
ENST00000230792.2
NUDT12
nudix (nucleoside diphosphate linked moiety X)-type motif 12
chr13_-_36050819 1.48 ENST00000379919.4
MAB21L1
mab-21-like 1 (C. elegans)
chr8_-_37351344 1.48 ENST00000520422.1
RP11-150O12.1
RP11-150O12.1
chr12_-_22063787 1.35 ENST00000544039.1
ABCC9
ATP-binding cassette, sub-family C (CFTR/MRP), member 9
chr15_+_94899183 1.34 ENST00000557742.1
MCTP2
multiple C2 domains, transmembrane 2
chr14_+_32798462 1.32 ENST00000280979.4
AKAP6
A kinase (PRKA) anchor protein 6
chr6_-_167040693 1.28 ENST00000366863.2
RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr4_-_103749205 1.25 ENST00000508249.1
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr8_-_29605625 1.25 ENST00000506121.3
LINC00589
long intergenic non-protein coding RNA 589
chr1_-_152386732 1.21 ENST00000271835.3
CRNN
cornulin
chr14_-_71276211 1.20 ENST00000381250.4
ENST00000555993.2
MAP3K9
mitogen-activated protein kinase kinase kinase 9
chr7_+_100770328 1.19 ENST00000223095.4
ENST00000445463.2
SERPINE1
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
chr10_+_24755416 1.16 ENST00000396446.1
ENST00000396445.1
ENST00000376451.2
KIAA1217
KIAA1217
chr3_+_183853052 1.15 ENST00000273783.3
ENST00000432569.1
ENST00000444495.1
EIF2B5
eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa
chr16_-_28608424 1.12 ENST00000335715.4
SULT1A2
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
chr6_-_111927449 1.11 ENST00000368761.5
ENST00000392556.4
ENST00000340026.6
TRAF3IP2
TRAF3 interacting protein 2
chr12_-_10022735 1.10 ENST00000228438.2
CLEC2B
C-type lectin domain family 2, member B
chr7_-_87856303 1.08 ENST00000394641.3
SRI
sorcin
chr1_-_17766198 1.01 ENST00000375436.4
RCC2
regulator of chromosome condensation 2
chr11_-_111741994 1.01 ENST00000398006.2
ALG9
ALG9, alpha-1,2-mannosyltransferase
chr12_+_64798826 1.01 ENST00000540203.1
XPOT
exportin, tRNA
chr5_-_94890648 0.99 ENST00000513823.1
ENST00000514952.1
ENST00000358746.2
TTC37
tetratricopeptide repeat domain 37
chr3_+_28390637 0.98 ENST00000420223.1
ENST00000383768.2
ZCWPW2
zinc finger, CW type with PWWP domain 2
chr1_+_43148059 0.97 ENST00000321358.7
ENST00000332220.6
YBX1
Y box binding protein 1
chr6_-_167040731 0.95 ENST00000265678.4
RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr8_-_112248400 0.93 ENST00000519506.1
ENST00000522778.1
RP11-946L20.4
RP11-946L20.4
chr6_-_111927062 0.91 ENST00000359831.4
TRAF3IP2
TRAF3 interacting protein 2
chr9_+_109685630 0.90 ENST00000451160.2
RP11-508N12.4
Uncharacterized protein
chr7_-_87856280 0.86 ENST00000490437.1
ENST00000431660.1
SRI
sorcin
chr15_-_43882140 0.81 ENST00000429176.1
PPIP5K1
diphosphoinositol pentakisphosphate kinase 1
chr3_-_55539287 0.81 ENST00000472238.1
RP11-875H7.5
RP11-875H7.5
chr4_-_103749179 0.80 ENST00000502690.1
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr4_+_77356248 0.77 ENST00000296043.6
SHROOM3
shroom family member 3
chr12_-_74686314 0.77 ENST00000551210.1
ENST00000515416.2
ENST00000549905.1
RP11-81H3.2
RP11-81H3.2
chr17_+_57232690 0.74 ENST00000262293.4
PRR11
proline rich 11
chr9_-_5339873 0.69 ENST00000223862.1
ENST00000223858.4
RLN1
relaxin 1
chr1_+_162336686 0.68 ENST00000420220.1
C1orf226
chromosome 1 open reading frame 226
chrX_-_77225135 0.67 ENST00000458128.1
PGAM4
phosphoglycerate mutase family member 4
chr1_-_28969517 0.67 ENST00000263974.4
ENST00000373824.4
TAF12
TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa
chr17_-_45266542 0.63 ENST00000531206.1
ENST00000527547.1
ENST00000446365.2
ENST00000575483.1
ENST00000066544.3
CDC27
cell division cycle 27
chr1_-_224624730 0.62 ENST00000445239.1
WDR26
WD repeat domain 26
chr4_-_103749313 0.62 ENST00000394803.5
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr2_-_169887827 0.60 ENST00000263817.6
ABCB11
ATP-binding cassette, sub-family B (MDR/TAP), member 11
chr16_+_53133070 0.59 ENST00000565832.1
CHD9
chromodomain helicase DNA binding protein 9
chr9_+_125133315 0.56 ENST00000223423.4
ENST00000362012.2
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr19_-_6424783 0.54 ENST00000398148.3
KHSRP
KH-type splicing regulatory protein
chr9_-_3469181 0.50 ENST00000366116.2
AL365202.1
Uncharacterized protein
chr17_-_57232596 0.47 ENST00000581068.1
ENST00000330137.7
SKA2
spindle and kinetochore associated complex subunit 2
chr5_-_159546396 0.45 ENST00000523662.1
ENST00000456329.3
ENST00000307063.7
PWWP2A
PWWP domain containing 2A
chrX_+_114827851 0.44 ENST00000539310.1
PLS3
plastin 3
chr2_+_113763031 0.40 ENST00000259211.6
IL36A
interleukin 36, alpha
chr2_+_217524323 0.40 ENST00000456764.1
IGFBP2
insulin-like growth factor binding protein 2, 36kDa
chr19_+_37742773 0.39 ENST00000438770.2
ENST00000591116.1
ENST00000592712.1
AC012309.5
AC012309.5
chr14_+_103851712 0.39 ENST00000440884.3
ENST00000416682.2
ENST00000429436.2
ENST00000303622.9
MARK3
MAP/microtubule affinity-regulating kinase 3
chr12_+_32832203 0.39 ENST00000553257.1
ENST00000549701.1
ENST00000358214.5
ENST00000266481.6
ENST00000551476.1
ENST00000550154.1
ENST00000547312.1
ENST00000414834.2
ENST00000381000.4
ENST00000548750.1
DNM1L
dynamin 1-like
chr16_-_28608364 0.37 ENST00000533150.1
SULT1A2
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
chr11_-_62521614 0.35 ENST00000527994.1
ENST00000394807.3
ZBTB3
zinc finger and BTB domain containing 3
chr4_-_103749105 0.33 ENST00000394801.4
ENST00000394804.2
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr8_+_105235572 0.33 ENST00000523362.1
RIMS2
regulating synaptic membrane exocytosis 2
chr19_-_3985455 0.33 ENST00000309311.6
EEF2
eukaryotic translation elongation factor 2
chr14_+_32798547 0.31 ENST00000557354.1
ENST00000557102.1
ENST00000557272.1
AKAP6
A kinase (PRKA) anchor protein 6
chr21_-_37914898 0.31 ENST00000399136.1
CLDN14
claudin 14
chr7_+_21582638 0.30 ENST00000409508.3
ENST00000328843.6
DNAH11
dynein, axonemal, heavy chain 11
chr2_-_74618964 0.30 ENST00000417090.1
ENST00000409868.1
DCTN1
dynactin 1
chr16_-_20702578 0.30 ENST00000307493.4
ENST00000219151.4
ACSM1
acyl-CoA synthetase medium-chain family member 1
chrX_+_107288280 0.30 ENST00000458383.1
VSIG1
V-set and immunoglobulin domain containing 1
chr5_+_63802109 0.27 ENST00000334025.2
RGS7BP
regulator of G-protein signaling 7 binding protein
chr13_+_111748183 0.26 ENST00000422994.1
LINC00368
long intergenic non-protein coding RNA 368
chr8_+_29605860 0.26 ENST00000517491.1
AC145110.1
AC145110.1
chr8_-_101571964 0.25 ENST00000520552.1
ENST00000521345.1
ENST00000523000.1
ENST00000335659.3
ENST00000358990.3
ENST00000519597.1
ANKRD46
ankyrin repeat domain 46
chr8_+_29605841 0.23 ENST00000523123.1
AC145110.1
AC145110.1
chr10_+_114206956 0.22 ENST00000432306.1
ENST00000393077.2
VTI1A
vesicle transport through interaction with t-SNAREs 1A
chr3_-_180397256 0.19 ENST00000442201.2
CCDC39
coiled-coil domain containing 39
chr10_+_35894338 0.18 ENST00000321660.1
GJD4
gap junction protein, delta 4, 40.1kDa
chr11_-_65625678 0.18 ENST00000308162.5
CFL1
cofilin 1 (non-muscle)
chr8_-_30670384 0.18 ENST00000221138.4
ENST00000518243.1
PPP2CB
protein phosphatase 2, catalytic subunit, beta isozyme
chr8_-_135522425 0.16 ENST00000521673.1
ZFAT
zinc finger and AT hook domain containing
chr4_+_80584903 0.14 ENST00000506460.1
RP11-452C8.1
RP11-452C8.1
chr8_+_107738240 0.14 ENST00000449762.2
ENST00000297447.6
OXR1
oxidation resistance 1
chr17_+_39346139 0.13 ENST00000398470.1
ENST00000318329.5
KRTAP9-1
keratin associated protein 9-1
chr3_+_45986511 0.13 ENST00000458629.1
ENST00000457814.1
CXCR6
chemokine (C-X-C motif) receptor 6
chr6_-_82957433 0.12 ENST00000306270.7
IBTK
inhibitor of Bruton agammaglobulinemia tyrosine kinase
chr16_+_82068585 0.12 ENST00000563491.1
HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr16_+_29832634 0.12 ENST00000565164.1
ENST00000570234.1
MVP
major vault protein
chr19_+_46236509 0.11 ENST00000457052.2
AC074212.3
Uncharacterized protein
chr19_+_37808831 0.10 ENST00000589801.1
HKR1
HKR1, GLI-Kruppel zinc finger family member
chr2_-_74619152 0.10 ENST00000440727.1
ENST00000409240.1
DCTN1
dynactin 1
chr10_-_4285923 0.10 ENST00000418372.1
ENST00000608792.1
LINC00702
long intergenic non-protein coding RNA 702
chr7_+_37723336 0.10 ENST00000450180.1
GPR141
G protein-coupled receptor 141
chr1_-_153123345 0.09 ENST00000368748.4
SPRR2G
small proline-rich protein 2G
chr19_+_54641444 0.09 ENST00000221232.5
ENST00000358389.3
CNOT3
CCR4-NOT transcription complex, subunit 3
chr2_+_187371440 0.09 ENST00000445547.1
ZC3H15
zinc finger CCCH-type containing 15
chr11_+_29181503 0.08 ENST00000530960.1
RP11-466I1.1
RP11-466I1.1
chr15_+_64680003 0.05 ENST00000261884.3
TRIP4
thyroid hormone receptor interactor 4
chrX_-_6453159 0.05 ENST00000381089.3
ENST00000398729.1
VCX3A
variable charge, X-linked 3A
chr2_+_112939365 0.04 ENST00000272559.4
FBLN7
fibulin 7
chr20_-_1447547 0.04 ENST00000476071.1
NSFL1C
NSFL1 (p97) cofactor (p47)
chr20_-_1447467 0.03 ENST00000353088.2
ENST00000350991.4
NSFL1C
NSFL1 (p97) cofactor (p47)
chr11_+_112047087 0.03 ENST00000526088.1
ENST00000532593.1
ENST00000531169.1
BCO2
beta-carotene oxygenase 2
chr9_+_125132803 0.02 ENST00000540753.1
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr9_+_125133467 0.02 ENST00000426608.1
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr7_+_70597109 0.01 ENST00000333538.5
WBSCR17
Williams-Beuren syndrome chromosome region 17
chr4_-_68829226 0.00 ENST00000396188.2
TMPRSS11A
transmembrane protease, serine 11A
chr1_-_92952433 0.00 ENST00000294702.5
GFI1
growth factor independent 1 transcription repressor

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX1-2_RAX

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 4.9 GO:0061713 neural crest cell migration involved in heart formation(GO:0003147) anterior neural tube closure(GO:0061713)
0.8 2.5 GO:0060488 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.6 2.9 GO:0043553 vascular endothelial growth factor receptor-2 signaling pathway(GO:0036324) negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.5 13.5 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.5 2.6 GO:0007070 negative regulation of transcription during mitosis(GO:0007068) negative regulation of transcription from RNA polymerase II promoter during mitosis(GO:0007070)
0.5 1.5 GO:0006742 NADP catabolic process(GO:0006742) pyridine nucleotide catabolic process(GO:0019364)
0.4 4.0 GO:0090063 positive regulation of microtubule nucleation(GO:0090063)
0.4 1.2 GO:0001300 chronological cell aging(GO:0001300)
0.3 1.0 GO:0072356 chromosome passenger complex localization to kinetochore(GO:0072356)
0.3 2.6 GO:1901189 positive regulation of ephrin receptor signaling pathway(GO:1901189) positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068)
0.3 7.4 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.3 11.4 GO:0031581 hemidesmosome assembly(GO:0031581)
0.3 1.5 GO:0044240 multicellular organism lipid catabolic process(GO:0044240)
0.3 1.9 GO:1903575 cornified envelope assembly(GO:1903575)
0.3 4.1 GO:0043249 erythrocyte maturation(GO:0043249)
0.2 1.9 GO:0006880 intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
0.2 3.3 GO:0042420 dopamine catabolic process(GO:0042420)
0.2 1.6 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.2 1.9 GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
0.2 0.7 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
0.1 1.2 GO:0007256 activation of JNKK activity(GO:0007256)
0.1 0.4 GO:0036466 synaptic vesicle recycling via endosome(GO:0036466)
0.1 3.0 GO:0044126 regulation of growth of symbiont in host(GO:0044126)
0.1 0.6 GO:0015722 canalicular bile acid transport(GO:0015722)
0.1 0.3 GO:0018874 benzoate metabolic process(GO:0018874)
0.1 1.0 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.1 3.5 GO:0048012 hepatocyte growth factor receptor signaling pathway(GO:0048012)
0.1 3.0 GO:0018345 protein palmitoylation(GO:0018345)
0.1 1.5 GO:0006068 ethanol catabolic process(GO:0006068)
0.1 2.0 GO:0002230 positive regulation of defense response to virus by host(GO:0002230)
0.1 3.4 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 6.1 GO:0001578 microtubule bundle formation(GO:0001578)
0.0 0.8 GO:0045176 apical protein localization(GO:0045176)
0.0 1.5 GO:0010226 response to lithium ion(GO:0010226)
0.0 0.3 GO:0003352 regulation of cilium movement(GO:0003352) regulation of cilium beat frequency(GO:0003356)
0.0 0.5 GO:2000628 regulation of miRNA metabolic process(GO:2000628)
0.0 1.0 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.0 0.8 GO:0006020 inositol metabolic process(GO:0006020)
0.0 0.2 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
0.0 0.3 GO:2000767 positive regulation of cytoplasmic translation(GO:2000767)
0.0 0.4 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.0 2.5 GO:0070206 protein trimerization(GO:0070206)
0.0 0.6 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.0 3.3 GO:0032508 DNA duplex unwinding(GO:0032508)
0.0 0.3 GO:0098814 spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814)
0.0 0.2 GO:2000782 regulation of unidimensional cell growth(GO:0051510) negative regulation of unidimensional cell growth(GO:0051511) establishment of cell polarity regulating cell shape(GO:0071964) regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000769) positive regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000771) regulation of establishment of cell polarity regulating cell shape(GO:2000782) positive regulation of establishment of cell polarity regulating cell shape(GO:2000784) positive regulation of barbed-end actin filament capping(GO:2000814)
0.0 5.8 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 2.1 GO:0031110 regulation of microtubule polymerization or depolymerization(GO:0031110)
0.0 0.2 GO:0014717 regulation of satellite cell activation involved in skeletal muscle regeneration(GO:0014717) satellite cell activation involved in skeletal muscle regeneration(GO:0014901)
0.0 2.2 GO:0043647 inositol phosphate metabolic process(GO:0043647)
0.0 1.3 GO:0010107 potassium ion import(GO:0010107)
0.0 1.8 GO:0030574 collagen catabolic process(GO:0030574)
0.0 1.0 GO:0006409 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.0 2.2 GO:0002456 T cell mediated immunity(GO:0002456)
0.0 7.0 GO:0018105 peptidyl-serine phosphorylation(GO:0018105)
0.0 0.1 GO:0031953 negative regulation of protein autophosphorylation(GO:0031953)
0.0 0.7 GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123)
0.0 2.2 GO:0031424 keratinization(GO:0031424)
0.0 0.3 GO:0051639 actin filament network formation(GO:0051639)
0.0 0.3 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 2.9 GO:1990032 parallel fiber(GO:1990032)
0.7 5.9 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.6 2.5 GO:0060187 cell pole(GO:0060187)
0.4 11.4 GO:0030056 hemidesmosome(GO:0030056)
0.4 7.3 GO:0060077 inhibitory synapse(GO:0060077)
0.3 2.6 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.2 1.0 GO:0055087 Ski complex(GO:0055087)
0.2 4.0 GO:0005869 dynactin complex(GO:0005869)
0.2 1.9 GO:0044326 dendritic spine neck(GO:0044326)
0.2 4.9 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.2 1.3 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.1 2.1 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.1 1.0 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
0.1 1.6 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.1 3.5 GO:0031528 microvillus membrane(GO:0031528)
0.1 2.6 GO:0071564 npBAF complex(GO:0071564)
0.1 1.9 GO:0043203 axon hillock(GO:0043203)
0.0 0.6 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 1.0 GO:1990023 mitotic spindle midzone(GO:1990023)
0.0 0.7 GO:0000124 SAGA complex(GO:0000124) STAGA complex(GO:0030914)
0.0 2.2 GO:0045095 keratin filament(GO:0045095)
0.0 0.3 GO:0042788 polysomal ribosome(GO:0042788)
0.0 2.1 GO:0015030 Cajal body(GO:0015030)
0.0 1.5 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 0.6 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.7 GO:0097228 sperm principal piece(GO:0097228)
0.0 0.1 GO:1990730 VCP-NSFL1C complex(GO:1990730)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 4.9 GO:0061714 folic acid receptor activity(GO:0061714)
0.5 13.5 GO:0001608 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.4 2.2 GO:0052829 inositol-1,4-bisphosphate 1-phosphatase activity(GO:0004441) inositol-1,3,4-trisphosphate 1-phosphatase activity(GO:0052829)
0.4 2.9 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
0.4 3.3 GO:0008131 primary amine oxidase activity(GO:0008131)
0.3 1.3 GO:0008281 sulfonylurea receptor activity(GO:0008281)
0.3 1.5 GO:0035529 NADH pyrophosphatase activity(GO:0035529)
0.3 1.2 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.3 2.9 GO:0008142 oxysterol binding(GO:0008142)
0.3 1.0 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.2 1.5 GO:0047894 flavonol 3-sulfotransferase activity(GO:0047894)
0.2 0.6 GO:0015432 bile acid-exporting ATPase activity(GO:0015432)
0.2 5.9 GO:0002162 dystroglycan binding(GO:0002162)
0.2 0.7 GO:0046538 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.1 2.6 GO:0030957 Tat protein binding(GO:0030957)
0.1 2.6 GO:0000150 recombinase activity(GO:0000150)
0.1 0.6 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.1 0.8 GO:0004771 sterol esterase activity(GO:0004771)
0.1 0.8 GO:0033857 diphosphoinositol-pentakisphosphate kinase activity(GO:0033857)
0.1 7.2 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
0.1 7.7 GO:0001784 phosphotyrosine binding(GO:0001784)
0.1 1.6 GO:0008179 adenylate cyclase binding(GO:0008179)
0.1 3.0 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.1 4.0 GO:0070840 dynein complex binding(GO:0070840)
0.1 3.4 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.0 2.6 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 1.9 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 11.7 GO:0000287 magnesium ion binding(GO:0000287)
0.0 0.4 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 0.3 GO:0004321 fatty-acyl-CoA synthase activity(GO:0004321)
0.0 0.1 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.0 1.2 GO:0031369 translation initiation factor binding(GO:0031369)
0.0 0.3 GO:0008097 5S rRNA binding(GO:0008097)
0.0 0.1 GO:0047006 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity(GO:0047006)
0.0 2.8 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.5 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 1.0 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 0.7 GO:0017025 TBP-class protein binding(GO:0017025)
0.0 0.4 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.0 1.3 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 1.8 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 2.3 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 0.3 GO:0045505 dynein intermediate chain binding(GO:0045505)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 11.1 NABA COLLAGENS Genes encoding collagen proteins
0.1 7.3 PID CD40 PATHWAY CD40/CD40L signaling
0.1 2.3 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.1 2.8 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.1 4.0 PID NCADHERIN PATHWAY N-cadherin signaling events
0.1 5.9 PID LKB1 PATHWAY LKB1 signaling events
0.0 2.9 PID RAS PATHWAY Regulation of Ras family activation
0.0 2.2 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.0 2.6 PID PS1 PATHWAY Presenilin action in Notch and Wnt signaling
0.0 3.5 PID MET PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.0 1.2 ST JNK MAPK PATHWAY JNK MAPK Pathway
0.0 1.2 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.7 PID MYC PATHWAY C-MYC pathway
0.0 3.6 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.0 PID PTP1B PATHWAY Signaling events mediated by PTP1B

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.3 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.1 2.6 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.1 11.1 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.1 7.7 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.1 2.8 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.1 3.0 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 1.8 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 4.0 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 1.5 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 2.4 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.0 0.6 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.0 1.3 REACTOME INWARDLY RECTIFYING K CHANNELS Genes involved in Inwardly rectifying K+ channels
0.0 1.2 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0 0.4 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.5 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 0.4 REACTOME PHOSPHORYLATION OF THE APC C Genes involved in Phosphorylation of the APC/C