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SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for NKX2-2

Z-value: 1.35

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Transcription factors associated with NKX2-2

Gene Symbol Gene ID Gene Info
NKX2-2
ENSG00000125820.5 NK2 homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NKX2-2hg19_v2_chr20_-_21494654_214946780.135.8e-01Click!

Activity profile of NKX2-2 motif

Sorted Z-values of NKX2-2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr5_+_150404904 12.07 ENST00000521632.1
GPX3
glutathione peroxidase 3 (plasma)
chr3_+_189507523 5.80 ENST00000437221.1
ENST00000392463.2
ENST00000392461.3
ENST00000449992.1
ENST00000456148.1
TP63
tumor protein p63
chr3_+_189507460 5.56 ENST00000434928.1
TP63
tumor protein p63
chr8_-_49833978 5.31 ENST00000020945.1
SNAI2
snail family zinc finger 2
chr8_-_49834299 5.10 ENST00000396822.1
SNAI2
snail family zinc finger 2
chr12_-_28124903 4.91 ENST00000395872.1
ENST00000354417.3
ENST00000201015.4
PTHLH
parathyroid hormone-like hormone
chr16_+_55600580 4.76 ENST00000457326.2
CAPNS2
calpain, small subunit 2
chr3_-_121379739 4.61 ENST00000428394.2
ENST00000314583.3
HCLS1
hematopoietic cell-specific Lyn substrate 1
chr3_+_189507432 4.33 ENST00000354600.5
TP63
tumor protein p63
chr1_-_153363452 4.10 ENST00000368732.1
ENST00000368733.3
S100A8
S100 calcium binding protein A8
chr5_+_147443534 3.49 ENST00000398454.1
ENST00000359874.3
ENST00000508733.1
ENST00000256084.7
SPINK5
serine peptidase inhibitor, Kazal type 5
chr2_-_214013353 3.47 ENST00000451136.2
ENST00000421754.2
ENST00000374327.4
ENST00000413091.3
IKZF2
IKAROS family zinc finger 2 (Helios)
chr1_-_161046266 3.36 ENST00000453926.2
PVRL4
poliovirus receptor-related 4
chr11_+_34654011 3.05 ENST00000531794.1
EHF
ets homologous factor
chr3_-_69249863 3.02 ENST00000478263.1
ENST00000462512.1
FRMD4B
FERM domain containing 4B
chr3_-_196911002 2.99 ENST00000452595.1
DLG1
discs, large homolog 1 (Drosophila)
chrX_+_115567767 2.95 ENST00000371900.4
SLC6A14
solute carrier family 6 (amino acid transporter), member 14
chr5_+_148206156 2.79 ENST00000305988.4
ADRB2
adrenoceptor beta 2, surface
chr17_-_8059638 2.69 ENST00000584202.1
ENST00000354903.5
ENST00000577253.1
PER1
period circadian clock 1
chr9_+_71820057 2.67 ENST00000539225.1
TJP2
tight junction protein 2
chr5_+_154181816 2.66 ENST00000518677.1
LARP1
La ribonucleoprotein domain family, member 1
chr4_+_160203650 2.64 ENST00000514565.1
RAPGEF2
Rap guanine nucleotide exchange factor (GEF) 2
chr2_+_102953608 2.63 ENST00000311734.2
ENST00000409584.1
IL1RL1
interleukin 1 receptor-like 1
chr22_-_43567750 2.59 ENST00000494035.1
TTLL12
tubulin tyrosine ligase-like family, member 12
chr7_+_2393714 2.55 ENST00000431643.1
EIF3B
eukaryotic translation initiation factor 3, subunit B
chr5_+_82767583 2.55 ENST00000512590.2
ENST00000513960.1
ENST00000513984.1
ENST00000502527.2
VCAN
versican
chr14_-_100841794 2.52 ENST00000556295.1
ENST00000554820.1
WARS
tryptophanyl-tRNA synthetase
chr12_+_69202795 2.50 ENST00000539479.1
ENST00000393415.3
ENST00000523991.1
ENST00000543323.1
ENST00000393416.2
MDM2
MDM2 oncogene, E3 ubiquitin protein ligase
chr9_+_71819927 2.48 ENST00000535702.1
TJP2
tight junction protein 2
chr4_-_99578789 2.47 ENST00000511651.1
ENST00000505184.1
TSPAN5
tetraspanin 5
chr13_-_86373536 2.46 ENST00000400286.2
SLITRK6
SLIT and NTRK-like family, member 6
chr11_-_128894053 2.44 ENST00000392657.3
ARHGAP32
Rho GTPase activating protein 32
chr2_+_208104497 2.42 ENST00000430494.1
AC007879.7
AC007879.7
chr3_+_190281229 2.40 ENST00000453359.1
IL1RAP
interleukin 1 receptor accessory protein
chrX_+_152953505 2.39 ENST00000253122.5
SLC6A8
solute carrier family 6 (neurotransmitter transporter), member 8
chr7_-_24957699 2.38 ENST00000441059.1
ENST00000415162.1
OSBPL3
oxysterol binding protein-like 3
chr1_-_22222764 2.36 ENST00000439717.2
ENST00000412328.1
HSPG2
heparan sulfate proteoglycan 2
chr1_+_117963209 2.35 ENST00000449370.2
MAN1A2
mannosidase, alpha, class 1A, member 2
chr18_+_55888767 2.31 ENST00000431212.2
ENST00000586268.1
ENST00000587190.1
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
chr18_-_68004529 2.29 ENST00000578633.1
RP11-484N16.1
RP11-484N16.1
chr6_+_32937083 2.24 ENST00000456339.1
BRD2
bromodomain containing 2
chr5_+_82767487 2.14 ENST00000343200.5
ENST00000342785.4
VCAN
versican
chr17_+_61086917 2.12 ENST00000424789.2
ENST00000389520.4
TANC2
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
chr10_-_4720301 2.10 ENST00000449712.1
LINC00704
long intergenic non-protein coding RNA 704
chr12_+_14572070 2.10 ENST00000545769.1
ENST00000428217.2
ENST00000396279.2
ENST00000542514.1
ENST00000536279.1
ATF7IP
activating transcription factor 7 interacting protein
chr8_-_101962777 2.10 ENST00000395951.3
YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
chr2_-_151344172 2.05 ENST00000375734.2
ENST00000263895.4
ENST00000454202.1
RND3
Rho family GTPase 3
chr15_+_79165222 2.03 ENST00000559930.1
MORF4L1
mortality factor 4 like 1
chr5_+_156887027 1.98 ENST00000435489.2
ENST00000311946.7
NIPAL4
NIPA-like domain containing 4
chr5_-_160365601 1.97 ENST00000518580.1
ENST00000518301.1
RP11-109J4.1
RP11-109J4.1
chr1_+_19967014 1.96 ENST00000428975.1
NBL1
neuroblastoma 1, DAN family BMP antagonist
chr3_+_41241596 1.94 ENST00000450969.1
CTNNB1
catenin (cadherin-associated protein), beta 1, 88kDa
chr6_-_150212029 1.82 ENST00000529948.1
ENST00000357183.4
ENST00000367363.3
RAET1E
retinoic acid early transcript 1E
chr13_+_25875785 1.79 ENST00000381747.3
NUPL1
nucleoporin like 1
chr19_+_58193388 1.73 ENST00000596085.1
ENST00000594684.1
ZNF551
AC003006.7
zinc finger protein 551
Uncharacterized protein
chr11_-_8892900 1.73 ENST00000526155.1
ENST00000524757.1
ENST00000527392.1
ENST00000534665.1
ENST00000525169.1
ENST00000527516.1
ENST00000533471.1
ST5
suppression of tumorigenicity 5
chr9_+_131447342 1.69 ENST00000409104.3
SET
SET nuclear oncogene
chr12_+_69202975 1.68 ENST00000544561.1
ENST00000393410.1
ENST00000299252.4
ENST00000360430.2
ENST00000517852.1
ENST00000545204.1
ENST00000393413.3
ENST00000350057.5
ENST00000348801.2
ENST00000478070.1
MDM2
MDM2 oncogene, E3 ubiquitin protein ligase
chr10_-_104913367 1.67 ENST00000423468.2
NT5C2
5'-nucleotidase, cytosolic II
chr2_+_192542879 1.65 ENST00000409510.1
NABP1
nucleic acid binding protein 1
chr14_-_100841670 1.64 ENST00000557297.1
ENST00000555813.1
ENST00000557135.1
ENST00000556698.1
ENST00000554509.1
ENST00000555410.1
WARS
tryptophanyl-tRNA synthetase
chr17_+_66521936 1.63 ENST00000592800.1
PRKAR1A
protein kinase, cAMP-dependent, regulatory, type I, alpha
chr2_+_17721230 1.61 ENST00000457525.1
VSNL1
visinin-like 1
chr17_+_66511224 1.58 ENST00000588178.1
PRKAR1A
protein kinase, cAMP-dependent, regulatory, type I, alpha
chr1_-_227505289 1.56 ENST00000366765.3
CDC42BPA
CDC42 binding protein kinase alpha (DMPK-like)
chr5_+_140800638 1.54 ENST00000398587.2
ENST00000518882.1
PCDHGA11
protocadherin gamma subfamily A, 11
chr7_-_84121858 1.54 ENST00000448879.1
SEMA3A
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr14_-_82000140 1.52 ENST00000555824.1
ENST00000557372.1
ENST00000336735.4
SEL1L
sel-1 suppressor of lin-12-like (C. elegans)
chr4_-_99578776 1.51 ENST00000515287.1
TSPAN5
tetraspanin 5
chr4_-_36246060 1.50 ENST00000303965.4
ARAP2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr11_-_11374904 1.47 ENST00000528848.2
CSNK2A3
casein kinase 2, alpha 3 polypeptide
chr12_+_76653611 1.46 ENST00000550380.1
RP11-54A9.1
RP11-54A9.1
chr1_-_202936394 1.44 ENST00000367249.4
CYB5R1
cytochrome b5 reductase 1
chrM_+_12331 1.43 ENST00000361567.2
MT-ND5
mitochondrially encoded NADH dehydrogenase 5
chr17_-_38859996 1.42 ENST00000264651.2
KRT24
keratin 24
chr19_-_51568324 1.41 ENST00000595547.1
ENST00000335422.3
ENST00000595793.1
ENST00000596955.1
KLK13
kallikrein-related peptidase 13
chr10_+_98741041 1.40 ENST00000286067.2
C10orf12
chromosome 10 open reading frame 12
chr6_-_27440460 1.40 ENST00000377419.1
ZNF184
zinc finger protein 184
chr19_+_7445850 1.40 ENST00000593531.1
CTD-2207O23.3
Rho guanine nucleotide exchange factor 18
chr16_-_69166031 1.39 ENST00000398235.2
ENST00000520529.1
CHTF8
CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae)
chr1_-_31538517 1.39 ENST00000440538.2
ENST00000423018.2
ENST00000424085.2
ENST00000426105.2
ENST00000257075.5
ENST00000373747.3
ENST00000525843.1
ENST00000373742.2
PUM1
pumilio RNA-binding family member 1
chr7_+_18548878 1.39 ENST00000456174.2
HDAC9
histone deacetylase 9
chr12_+_76653682 1.38 ENST00000553247.1
RP11-54A9.1
RP11-54A9.1
chr10_+_13628921 1.38 ENST00000378572.3
PRPF18
pre-mRNA processing factor 18
chr3_-_33686925 1.37 ENST00000485378.2
ENST00000313350.6
ENST00000487200.1
CLASP2
cytoplasmic linker associated protein 2
chr2_-_214014959 1.37 ENST00000442445.1
ENST00000457361.1
ENST00000342002.2
IKZF2
IKAROS family zinc finger 2 (Helios)
chr3_+_63953415 1.36 ENST00000484332.1
ATXN7
ataxin 7
chr2_+_192543694 1.33 ENST00000435931.1
NABP1
nucleic acid binding protein 1
chr2_+_192543153 1.30 ENST00000425611.2
NABP1
nucleic acid binding protein 1
chr17_+_74372662 1.28 ENST00000591651.1
ENST00000545180.1
SPHK1
sphingosine kinase 1
chr22_-_36220420 1.28 ENST00000473487.2
RBFOX2
RNA binding protein, fox-1 homolog (C. elegans) 2
chrX_-_32173579 1.26 ENST00000359836.1
ENST00000343523.2
ENST00000378707.3
ENST00000541735.1
ENST00000474231.1
DMD
dystrophin
chr16_+_23194033 1.26 ENST00000300061.2
SCNN1G
sodium channel, non-voltage-gated 1, gamma subunit
chr13_-_99630233 1.24 ENST00000376460.1
ENST00000442173.1
DOCK9
dedicator of cytokinesis 9
chr4_-_119759795 1.17 ENST00000419654.2
SEC24D
SEC24 family member D
chr10_+_63808970 1.16 ENST00000309334.5
ARID5B
AT rich interactive domain 5B (MRF1-like)
chr13_-_41240717 1.16 ENST00000379561.5
FOXO1
forkhead box O1
chr5_-_124084493 1.16 ENST00000509799.1
ZNF608
zinc finger protein 608
chr11_+_64949899 1.15 ENST00000531068.1
ENST00000527699.1
ENST00000533909.1
ENST00000527323.1
CAPN1
calpain 1, (mu/I) large subunit
chr7_+_18548924 1.14 ENST00000524023.1
HDAC9
histone deacetylase 9
chr5_+_108083517 1.14 ENST00000281092.4
ENST00000536402.1
FER
fer (fps/fes related) tyrosine kinase
chr2_+_219110149 1.13 ENST00000456575.1
ARPC2
actin related protein 2/3 complex, subunit 2, 34kDa
chr1_+_104293028 1.13 ENST00000370079.3
AMY1C
amylase, alpha 1C (salivary)
chr20_-_36152914 1.12 ENST00000397131.1
BLCAP
bladder cancer associated protein
chr4_+_3076388 1.11 ENST00000355072.5
HTT
huntingtin
chr6_-_11779014 1.10 ENST00000229583.5
ADTRP
androgen-dependent TFPI-regulating protein
chr2_-_70409953 1.09 ENST00000419381.1
C2orf42
chromosome 2 open reading frame 42
chr8_-_99954788 1.08 ENST00000523601.1
STK3
serine/threonine kinase 3
chr5_+_179135246 1.08 ENST00000508787.1
CANX
calnexin
chr11_-_7698453 1.07 ENST00000524608.1
CYB5R2
cytochrome b5 reductase 2
chrX_+_123095546 1.07 ENST00000371157.3
ENST00000371145.3
ENST00000371144.3
STAG2
stromal antigen 2
chr4_+_87928140 1.07 ENST00000307808.6
AFF1
AF4/FMR2 family, member 1
chr3_-_69101461 1.06 ENST00000543976.1
TMF1
TATA element modulatory factor 1
chr13_+_25875662 1.05 ENST00000381736.3
ENST00000463407.1
ENST00000381718.3
NUPL1
nucleoporin like 1
chr9_+_123970052 1.03 ENST00000373823.3
GSN
gelsolin
chr10_+_13628933 1.02 ENST00000417658.1
ENST00000320054.4
PRPF18
pre-mRNA processing factor 18
chr1_-_154150651 1.01 ENST00000302206.5
TPM3
tropomyosin 3
chr6_+_158733692 1.00 ENST00000367094.2
ENST00000367097.3
TULP4
tubby like protein 4
chr4_+_144303093 1.00 ENST00000505913.1
GAB1
GRB2-associated binding protein 1
chr5_-_110848253 0.97 ENST00000505803.1
ENST00000502322.1
STARD4
StAR-related lipid transfer (START) domain containing 4
chr14_-_100841930 0.96 ENST00000555031.1
ENST00000553395.1
ENST00000553545.1
ENST00000344102.5
ENST00000556338.1
ENST00000392882.2
ENST00000553934.1
WARS
tryptophanyl-tRNA synthetase
chr1_-_9953295 0.95 ENST00000377258.1
CTNNBIP1
catenin, beta interacting protein 1
chr7_+_133615169 0.94 ENST00000541309.1
EXOC4
exocyst complex component 4
chr13_+_113863858 0.94 ENST00000375440.4
CUL4A
cullin 4A
chr15_+_79165296 0.93 ENST00000558746.1
ENST00000558830.1
ENST00000559345.1
MORF4L1
mortality factor 4 like 1
chr4_+_56719782 0.93 ENST00000381295.2
ENST00000346134.7
ENST00000349598.6
EXOC1
exocyst complex component 1
chr7_+_115862858 0.93 ENST00000393481.2
TES
testis derived transcript (3 LIM domains)
chr15_-_60683326 0.92 ENST00000559350.1
ENST00000558986.1
ENST00000560389.1
ANXA2
annexin A2
chr7_+_102715573 0.91 ENST00000434153.1
ARMC10
armadillo repeat containing 10
chr5_+_34757309 0.90 ENST00000397449.1
RAI14
retinoic acid induced 14
chr5_+_125758865 0.90 ENST00000542322.1
ENST00000544396.1
GRAMD3
GRAM domain containing 3
chr2_+_171034646 0.89 ENST00000409044.3
ENST00000408978.4
MYO3B
myosin IIIB
chr6_+_45296048 0.88 ENST00000465038.2
ENST00000352853.5
ENST00000541979.1
ENST00000371438.1
RUNX2
runt-related transcription factor 2
chr15_-_42840961 0.87 ENST00000563454.1
ENST00000397130.3
ENST00000570160.1
ENST00000323443.2
LRRC57
leucine rich repeat containing 57
chrY_+_15418467 0.86 ENST00000595988.1
AC010877.1
Uncharacterized protein
chr3_+_38206975 0.84 ENST00000446845.1
ENST00000311806.3
OXSR1
oxidative stress responsive 1
chr16_+_53241854 0.83 ENST00000565803.1
CHD9
chromodomain helicase DNA binding protein 9
chrX_-_130037162 0.82 ENST00000432489.1
ENOX2
ecto-NOX disulfide-thiol exchanger 2
chr8_+_26150628 0.82 ENST00000523925.1
ENST00000315985.7
PPP2R2A
protein phosphatase 2, regulatory subunit B, alpha
chr6_-_80247105 0.82 ENST00000369846.4
LCA5
Leber congenital amaurosis 5
chr1_+_67395922 0.81 ENST00000401042.3
ENST00000355356.3
MIER1
mesoderm induction early response 1, transcriptional regulator
chr13_+_111766897 0.81 ENST00000317133.5
ARHGEF7
Rho guanine nucleotide exchange factor (GEF) 7
chr6_-_80247140 0.81 ENST00000392959.1
ENST00000467898.3
LCA5
Leber congenital amaurosis 5
chr11_-_107729887 0.80 ENST00000525815.1
SLC35F2
solute carrier family 35, member F2
chr12_+_25205446 0.80 ENST00000557489.1
ENST00000354454.3
ENST00000536173.1
LRMP
lymphoid-restricted membrane protein
chr5_+_159656437 0.79 ENST00000402432.3
FABP6
fatty acid binding protein 6, ileal
chr8_-_141810634 0.78 ENST00000521986.1
ENST00000523539.1
ENST00000538769.1
PTK2
protein tyrosine kinase 2
chr1_-_110155671 0.77 ENST00000351050.3
GNAT2
guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
chr5_+_125758813 0.77 ENST00000285689.3
ENST00000515200.1
GRAMD3
GRAM domain containing 3
chr17_+_75315654 0.77 ENST00000590595.1
SEPT9
septin 9
chr11_+_9406169 0.76 ENST00000379719.3
ENST00000527431.1
IPO7
importin 7
chr1_+_84629976 0.76 ENST00000446538.1
ENST00000370684.1
ENST00000436133.1
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr5_+_118668846 0.76 ENST00000513374.1
TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chr15_-_38519066 0.76 ENST00000561320.1
ENST00000561161.1
RP11-346D14.1
RP11-346D14.1
chr9_+_129097520 0.73 ENST00000436593.3
MVB12B
multivesicular body subunit 12B
chr12_+_19389814 0.73 ENST00000536974.1
PLEKHA5
pleckstrin homology domain containing, family A member 5
chr9_+_137218362 0.72 ENST00000481739.1
RXRA
retinoid X receptor, alpha
chr17_+_75315534 0.71 ENST00000590294.1
ENST00000329047.8
SEPT9
septin 9
chr3_-_69101413 0.71 ENST00000398559.2
TMF1
TATA element modulatory factor 1
chr13_-_36944307 0.70 ENST00000355182.4
SPG20
spastic paraplegia 20 (Troyer syndrome)
chr4_-_140477928 0.69 ENST00000274031.3
SETD7
SET domain containing (lysine methyltransferase) 7
chr12_-_10875831 0.69 ENST00000279550.7
ENST00000228251.4
YBX3
Y box binding protein 3
chr14_-_31856397 0.69 ENST00000538864.2
ENST00000550366.1
HEATR5A
HEAT repeat containing 5A
chr13_-_33112956 0.68 ENST00000505213.1
N4BP2L2
NEDD4 binding protein 2-like 2
chr13_+_111855414 0.67 ENST00000375737.5
ARHGEF7
Rho guanine nucleotide exchange factor (GEF) 7
chr6_+_45296391 0.66 ENST00000371436.6
ENST00000576263.1
RUNX2
runt-related transcription factor 2
chr10_-_104262460 0.66 ENST00000446605.2
ENST00000369905.4
ENST00000545684.1
ACTR1A
ARP1 actin-related protein 1 homolog A, centractin alpha (yeast)
chr2_-_160472052 0.66 ENST00000437839.1
BAZ2B
bromodomain adjacent to zinc finger domain, 2B
chr10_+_102295616 0.65 ENST00000299163.6
HIF1AN
hypoxia inducible factor 1, alpha subunit inhibitor
chr11_+_65266507 0.65 ENST00000544868.1
MALAT1
metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)
chr18_-_43684230 0.63 ENST00000592989.1
ENST00000589869.1
ATP5A1
ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
chr6_+_32936353 0.62 ENST00000374825.4
BRD2
bromodomain containing 2
chr8_-_18666360 0.62 ENST00000286485.8
PSD3
pleckstrin and Sec7 domain containing 3
chr8_+_94767109 0.62 ENST00000409623.3
ENST00000453906.1
ENST00000521517.1
TMEM67
transmembrane protein 67
chr5_-_179047881 0.60 ENST00000521173.1
HNRNPH1
heterogeneous nuclear ribonucleoprotein H1 (H)
chr12_+_32552451 0.60 ENST00000534526.2
FGD4
FYVE, RhoGEF and PH domain containing 4
chr8_-_122653630 0.60 ENST00000303924.4
HAS2
hyaluronan synthase 2
chr6_+_44355257 0.59 ENST00000371477.3
CDC5L
cell division cycle 5-like
chr8_+_11666649 0.59 ENST00000528643.1
ENST00000525777.1
FDFT1
farnesyl-diphosphate farnesyltransferase 1
chr20_+_56964169 0.59 ENST00000475243.1
VAPB
VAMP (vesicle-associated membrane protein)-associated protein B and C
chr12_+_25205155 0.58 ENST00000550945.1
LRMP
lymphoid-restricted membrane protein
chr2_+_183582774 0.58 ENST00000537515.1
DNAJC10
DnaJ (Hsp40) homolog, subfamily C, member 10
chr22_+_42086547 0.58 ENST00000402966.1
C22orf46
chromosome 22 open reading frame 46
chr7_-_17598506 0.57 ENST00000451792.1
AC017060.1
AC017060.1
chr5_+_125759140 0.57 ENST00000543198.1
GRAMD3
GRAM domain containing 3
chr12_+_41136144 0.57 ENST00000548005.1
ENST00000552248.1
CNTN1
contactin 1
chr3_+_142838091 0.57 ENST00000309575.3
CHST2
carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
chr6_+_158957431 0.56 ENST00000367090.3
TMEM181
transmembrane protein 181
chr1_-_207095324 0.56 ENST00000530505.1
ENST00000367091.3
ENST00000442471.2
FAIM3
Fas apoptotic inhibitory molecule 3
chr7_+_16700806 0.55 ENST00000446596.1
ENST00000438834.1
BZW2
basic leucine zipper and W2 domains 2
chr3_+_69811858 0.55 ENST00000433517.1
MITF
microphthalmia-associated transcription factor
chr1_-_155880672 0.53 ENST00000609492.1
ENST00000368322.3
RIT1
Ras-like without CAAX 1
chr12_+_100750846 0.53 ENST00000323346.5
SLC17A8
solute carrier family 17 (vesicular glutamate transporter), member 8
chr1_+_180601139 0.52 ENST00000367590.4
ENST00000367589.3
XPR1
xenotropic and polytropic retrovirus receptor 1
chr1_-_182573514 0.52 ENST00000367558.5
RGS16
regulator of G-protein signaling 16
chr2_+_238969728 0.51 ENST00000416757.1
SCLY
selenocysteine lyase
chr3_+_179280668 0.51 ENST00000429709.2
ENST00000450518.2
ENST00000392662.1
ENST00000490364.1
ACTL6A
actin-like 6A
chr2_+_74229812 0.51 ENST00000305799.7
TET3
tet methylcytosine dioxygenase 3
chr19_-_3971050 0.51 ENST00000545797.2
ENST00000596311.1
DAPK3
death-associated protein kinase 3
chr5_-_150521192 0.50 ENST00000523714.1
ENST00000521749.1
ANXA6
annexin A6

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX2-2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
3.9 15.7 GO:0007499 ectoderm and mesoderm interaction(GO:0007499)
3.5 10.4 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
1.7 12.1 GO:0006982 response to lipid hydroperoxide(GO:0006982)
1.4 4.2 GO:1904404 cellular response to vitamin B1(GO:0071301) response to formaldehyde(GO:1904404)
0.9 2.8 GO:0002025 vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure(GO:0002025)
0.9 5.1 GO:0006436 tryptophanyl-tRNA aminoacylation(GO:0006436)
0.8 2.4 GO:0071030 nuclear mRNA surveillance of spliceosomal pre-mRNA splicing(GO:0071030) nuclear retention of unspliced pre-mRNA at the site of transcription(GO:0071048)
0.8 2.4 GO:1902598 creatine transport(GO:0015881) creatine transmembrane transport(GO:1902598)
0.7 5.0 GO:0038172 interleukin-33-mediated signaling pathway(GO:0038172)
0.5 5.1 GO:0071847 TNFSF11-mediated signaling pathway(GO:0071847)
0.5 3.5 GO:0002786 regulation of antimicrobial peptide production(GO:0002784) regulation of antibacterial peptide production(GO:0002786)
0.5 1.9 GO:1904793 glial cell fate determination(GO:0007403) canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation(GO:0061324) regulation of chromatin-mediated maintenance of transcription(GO:1904499) positive regulation of chromatin-mediated maintenance of transcription(GO:1904501) regulation of euchromatin binding(GO:1904793)
0.4 2.7 GO:0072752 cellular response to rapamycin(GO:0072752)
0.4 1.3 GO:0046521 sphingoid catabolic process(GO:0046521)
0.4 1.7 GO:1903045 neural crest cell migration involved in sympathetic nervous system development(GO:1903045)
0.4 2.5 GO:0060005 vestibular reflex(GO:0060005)
0.4 2.0 GO:0038098 sequestering of BMP from receptor via BMP binding(GO:0038098)
0.4 1.1 GO:0010877 lipid transport involved in lipid storage(GO:0010877)
0.4 1.1 GO:0050904 response to stem cell factor(GO:0036215) cellular response to stem cell factor stimulus(GO:0036216) Kit signaling pathway(GO:0038109) diapedesis(GO:0050904)
0.4 2.6 GO:2000670 positive regulation of dendritic cell apoptotic process(GO:2000670)
0.4 1.1 GO:0031587 positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0031587)
0.4 1.8 GO:2000843 testosterone secretion(GO:0035936) regulation of testosterone secretion(GO:2000843) positive regulation of testosterone secretion(GO:2000845)
0.3 2.7 GO:2000323 negative regulation of glucocorticoid receptor signaling pathway(GO:2000323)
0.3 2.4 GO:1904381 Golgi apparatus mannose trimming(GO:1904381)
0.3 2.3 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.3 3.0 GO:1903764 regulation of potassium ion export across plasma membrane(GO:1903764)
0.3 2.8 GO:0075525 viral translational termination-reinitiation(GO:0075525)
0.3 0.8 GO:2000681 negative regulation of rubidium ion transport(GO:2000681) negative regulation of rubidium ion transmembrane transporter activity(GO:2000687)
0.3 4.7 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.2 3.9 GO:0032119 sequestering of zinc ion(GO:0032119)
0.2 0.7 GO:0045994 positive regulation of translational initiation by iron(GO:0045994)
0.2 1.0 GO:0044855 plasma membrane raft distribution(GO:0044855) plasma membrane raft localization(GO:0044856) plasma membrane raft polarization(GO:0044858) regulation of plasma membrane raft polarization(GO:1903906)
0.2 1.0 GO:0006696 ergosterol biosynthetic process(GO:0006696) ergosterol metabolic process(GO:0008204)
0.2 1.2 GO:0035947 regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter(GO:0035947)
0.2 0.9 GO:0002528 regulation of vascular permeability involved in acute inflammatory response(GO:0002528)
0.2 1.1 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.2 0.7 GO:0048698 negative regulation of collateral sprouting in absence of injury(GO:0048698)
0.2 1.2 GO:0019075 virus maturation(GO:0019075)
0.2 0.5 GO:0044727 DNA demethylation of male pronucleus(GO:0044727)
0.2 0.7 GO:0052363 multi-organism catabolic process(GO:0044035) development of symbiont involved in interaction with host(GO:0044115) modulation of development of symbiont involved in interaction with host(GO:0044145) negative regulation of development of symbiont involved in interaction with host(GO:0044147) metabolism of substance in other organism involved in symbiotic interaction(GO:0052214) catabolism of substance in other organism involved in symbiotic interaction(GO:0052227) metabolism of macromolecule in other organism involved in symbiotic interaction(GO:0052229) catabolism by host of symbiont macromolecule(GO:0052360) catabolism by organism of macromolecule in other organism involved in symbiotic interaction(GO:0052361) catabolism by host of symbiont protein(GO:0052362) catabolism by organism of protein in other organism involved in symbiotic interaction(GO:0052363) catabolism by host of substance in symbiont(GO:0052364) metabolism by host of symbiont macromolecule(GO:0052416) metabolism by host of symbiont protein(GO:0052417) metabolism by organism of protein in other organism involved in symbiotic interaction(GO:0052418) metabolism by host of substance in symbiont(GO:0052419)
0.2 4.7 GO:0030208 dermatan sulfate biosynthetic process(GO:0030208)
0.2 4.9 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)
0.1 0.6 GO:0046379 extracellular polysaccharide biosynthetic process(GO:0045226) extracellular polysaccharide metabolic process(GO:0046379)
0.1 0.6 GO:1990637 response to prolactin(GO:1990637)
0.1 3.2 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.1 1.9 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
0.1 0.9 GO:2000819 regulation of nucleotide-excision repair(GO:2000819)
0.1 1.3 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.1 2.0 GO:0015693 magnesium ion transport(GO:0015693)
0.1 0.4 GO:0098884 postsynaptic neurotransmitter receptor internalization(GO:0098884)
0.1 2.5 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.1 1.5 GO:0002051 osteoblast fate commitment(GO:0002051)
0.1 0.5 GO:0060940 epithelial to mesenchymal transition involved in cardiac fibroblast development(GO:0060940)
0.1 2.1 GO:0090168 Golgi reassembly(GO:0090168)
0.1 1.4 GO:1900246 positive regulation of RIG-I signaling pathway(GO:1900246)
0.1 0.7 GO:0061428 negative regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061428)
0.1 1.8 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.1 1.3 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.1 3.6 GO:0043968 histone H2A acetylation(GO:0043968)
0.1 0.7 GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining(GO:2001034)
0.1 0.9 GO:0097338 response to clozapine(GO:0097338)
0.1 1.0 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.1 1.7 GO:0046085 adenosine metabolic process(GO:0046085)
0.1 1.8 GO:1904424 regulation of GTP binding(GO:1904424)
0.1 0.3 GO:1902396 protein localization to bicellular tight junction(GO:1902396)
0.1 0.9 GO:0048341 paraxial mesoderm formation(GO:0048341)
0.1 4.0 GO:0045747 positive regulation of Notch signaling pathway(GO:0045747)
0.1 1.1 GO:0060056 mammary gland involution(GO:0060056)
0.1 0.7 GO:1902035 positive regulation of hematopoietic stem cell proliferation(GO:1902035)
0.1 1.7 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.1 1.1 GO:0038007 netrin-activated signaling pathway(GO:0038007)
0.1 0.2 GO:0009405 pathogenesis(GO:0009405)
0.1 2.9 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.1 0.8 GO:0042670 retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549)
0.1 1.9 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.1 0.8 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043154)
0.1 1.1 GO:0031937 positive regulation of chromatin silencing(GO:0031937)
0.1 0.7 GO:2000767 negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902219) positive regulation of cytoplasmic translation(GO:2000767)
0.1 1.4 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.1 0.3 GO:0072560 glandular epithelial cell maturation(GO:0002071) type B pancreatic cell maturation(GO:0072560)
0.1 0.4 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.1 0.3 GO:1904274 tricellular tight junction assembly(GO:1904274)
0.1 0.6 GO:0006987 activation of signaling protein activity involved in unfolded protein response(GO:0006987)
0.1 1.2 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.1 0.4 GO:0032380 regulation of intracellular lipid transport(GO:0032377) regulation of intracellular sterol transport(GO:0032380) regulation of intracellular cholesterol transport(GO:0032383)
0.0 0.4 GO:1904694 negative regulation of vascular smooth muscle contraction(GO:1904694)
0.0 0.9 GO:0051601 exocyst localization(GO:0051601)
0.0 1.5 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.0 0.7 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.0 0.4 GO:0030242 pexophagy(GO:0030242)
0.0 7.0 GO:0022617 extracellular matrix disassembly(GO:0022617)
0.0 3.0 GO:0008206 bile acid metabolic process(GO:0008206)
0.0 1.6 GO:1904380 endoplasmic reticulum mannose trimming(GO:1904380)
0.0 0.3 GO:0001781 neutrophil apoptotic process(GO:0001781) regulation of neutrophil apoptotic process(GO:0033029) common myeloid progenitor cell proliferation(GO:0035726)
0.0 1.1 GO:0010592 positive regulation of lamellipodium assembly(GO:0010592)
0.0 0.8 GO:0007084 mitotic nuclear envelope reassembly(GO:0007084)
0.0 4.3 GO:0042795 snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.0 0.5 GO:0001887 selenium compound metabolic process(GO:0001887)
0.0 0.4 GO:0043923 positive regulation by host of viral transcription(GO:0043923)
0.0 0.2 GO:0072369 regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369)
0.0 0.2 GO:1902498 regulation of protein autoubiquitination(GO:1902498)
0.0 0.3 GO:0042780 tRNA 3'-end processing(GO:0042780)
0.0 0.9 GO:0035067 negative regulation of histone acetylation(GO:0035067)
0.0 0.3 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.0 1.6 GO:0046676 negative regulation of insulin secretion(GO:0046676)
0.0 1.0 GO:0035728 response to hepatocyte growth factor(GO:0035728)
0.0 0.7 GO:0061458 reproductive system development(GO:0061458)
0.0 0.3 GO:0097094 craniofacial suture morphogenesis(GO:0097094)
0.0 0.1 GO:0044245 polysaccharide digestion(GO:0044245)
0.0 0.6 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.0 0.5 GO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001241)
0.0 1.5 GO:0001913 T cell mediated cytotoxicity(GO:0001913)
0.0 1.1 GO:0030262 apoptotic nuclear changes(GO:0030262)
0.0 1.2 GO:0016577 histone demethylation(GO:0016577)
0.0 0.3 GO:0070070 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.0 0.3 GO:1904293 negative regulation of ERAD pathway(GO:1904293)
0.0 0.4 GO:0010603 regulation of cytoplasmic mRNA processing body assembly(GO:0010603)
0.0 0.1 GO:1903371 regulation of endoplasmic reticulum tubular network organization(GO:1903371)
0.0 0.6 GO:0006044 N-acetylglucosamine metabolic process(GO:0006044)
0.0 0.2 GO:1904322 response to forskolin(GO:1904321) cellular response to forskolin(GO:1904322)
0.0 2.3 GO:0016126 sterol biosynthetic process(GO:0016126)
0.0 0.6 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.0 0.5 GO:2000144 positive regulation of DNA-templated transcription, initiation(GO:2000144)
0.0 0.2 GO:0006006 glucose metabolic process(GO:0006006)
0.0 0.2 GO:0015727 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873)
0.0 1.3 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 0.2 GO:0070197 meiotic telomere tethering at nuclear periphery(GO:0044821) meiotic attachment of telomere to nuclear envelope(GO:0070197) chromosome attachment to the nuclear envelope(GO:0097240)
0.0 0.4 GO:0032802 low-density lipoprotein particle receptor catabolic process(GO:0032802)
0.0 0.5 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.0 0.2 GO:0007000 nucleolus organization(GO:0007000)
0.0 0.1 GO:0019249 lactate biosynthetic process(GO:0019249)
0.0 0.5 GO:0035435 phosphate ion transmembrane transport(GO:0035435)
0.0 2.1 GO:0006903 vesicle targeting(GO:0006903)
0.0 1.3 GO:0050891 multicellular organismal water homeostasis(GO:0050891)
0.0 2.1 GO:0070268 cornification(GO:0070268)
0.0 0.3 GO:0032486 Rap protein signal transduction(GO:0032486)
0.0 0.1 GO:0042797 5S class rRNA transcription from RNA polymerase III type 1 promoter(GO:0042791) tRNA transcription from RNA polymerase III promoter(GO:0042797)
0.0 0.5 GO:0051560 mitochondrial calcium ion homeostasis(GO:0051560)
0.0 0.1 GO:0010792 DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792)
0.0 0.1 GO:0016554 cytidine to uridine editing(GO:0016554)
0.0 0.2 GO:0033962 cytoplasmic mRNA processing body assembly(GO:0033962)
0.0 0.1 GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0 0.4 GO:0071577 zinc II ion transmembrane transport(GO:0071577)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.4 GO:0071020 post-spliceosomal complex(GO:0071020)
0.5 4.3 GO:0070876 SOSS complex(GO:0070876)
0.5 3.5 GO:0097209 epidermal lamellar body(GO:0097209)
0.4 1.1 GO:0036194 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.4 1.9 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.3 2.8 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.2 1.9 GO:0070369 Scrib-APC-beta-catenin complex(GO:0034750) beta-catenin-TCF7L2 complex(GO:0070369)
0.2 0.9 GO:0098592 cytoplasmic side of apical plasma membrane(GO:0098592)
0.2 3.0 GO:0097025 lateral loop(GO:0043219) MPP7-DLG1-LIN7 complex(GO:0097025)
0.2 0.5 GO:0097451 basilar dendrite(GO:0097441) glial limiting end-foot(GO:0097451)
0.2 2.7 GO:0031931 TORC1 complex(GO:0031931)
0.2 4.1 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 1.8 GO:0000322 storage vacuole(GO:0000322)
0.1 1.3 GO:0016013 syntrophin complex(GO:0016013)
0.1 0.7 GO:1990667 PCSK9-AnxA2 complex(GO:1990667)
0.1 0.4 GO:0098844 postsynaptic endocytic zone membrane(GO:0098844)
0.1 0.5 GO:0071006 U2-type catalytic step 1 spliceosome(GO:0071006)
0.1 1.4 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.1 0.9 GO:0002177 manchette(GO:0002177)
0.1 1.8 GO:0005828 kinetochore microtubule(GO:0005828)
0.1 2.4 GO:0032433 filopodium tip(GO:0032433)
0.1 13.0 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.1 1.2 GO:0001940 male pronucleus(GO:0001940)
0.1 0.9 GO:0032584 growth cone membrane(GO:0032584)
0.1 3.6 GO:1902562 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.1 1.0 GO:0030478 actin cap(GO:0030478)
0.1 1.2 GO:0000813 ESCRT I complex(GO:0000813)
0.1 0.6 GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.1 0.9 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.1 1.4 GO:0030127 COPII vesicle coat(GO:0030127)
0.1 0.4 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.0 1.0 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 0.9 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.0 1.4 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 1.5 GO:0031105 septin complex(GO:0031105)
0.0 8.4 GO:0005923 bicellular tight junction(GO:0005923)
0.0 0.3 GO:0061689 tricellular tight junction(GO:0061689)
0.0 5.1 GO:0005796 Golgi lumen(GO:0005796)
0.0 0.8 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 0.6 GO:0000974 Prp19 complex(GO:0000974) DNA replication factor A complex(GO:0005662)
0.0 2.3 GO:0005771 multivesicular body(GO:0005771)
0.0 0.6 GO:0036038 MKS complex(GO:0036038)
0.0 0.7 GO:0016459 myosin complex(GO:0016459)
0.0 2.5 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 13.7 GO:0000790 nuclear chromatin(GO:0000790)
0.0 0.6 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 2.7 GO:0005811 lipid particle(GO:0005811)
0.0 2.1 GO:0031526 brush border membrane(GO:0031526)
0.0 0.7 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 4.2 GO:0030666 endocytic vesicle membrane(GO:0030666)
0.0 0.3 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.0 1.5 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.4 GO:0005902 microvillus(GO:0005902)
0.0 3.2 GO:0030665 clathrin-coated vesicle membrane(GO:0030665)
0.0 1.4 GO:0035577 azurophil granule membrane(GO:0035577)
0.0 1.3 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.8 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.2 GO:0005688 U6 snRNP(GO:0005688)
0.0 2.7 GO:0048770 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 4.3 GO:0045111 intermediate filament cytoskeleton(GO:0045111)
0.0 1.4 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 3.6 GO:0001650 fibrillar center(GO:0001650)
0.0 1.9 GO:0042641 actomyosin(GO:0042641)
0.0 0.4 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 0.3 GO:0030057 desmosome(GO:0030057)
0.0 0.1 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.0 0.3 GO:0005922 connexon complex(GO:0005922)
0.0 3.5 GO:0001726 ruffle(GO:0001726)
0.0 5.0 GO:0005667 transcription factor complex(GO:0005667)
0.0 0.8 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 0.2 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.0 1.4 GO:0016363 nuclear matrix(GO:0016363)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 4.2 GO:0061663 NEDD8 ligase activity(GO:0061663)
1.0 15.7 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.9 2.8 GO:0004939 beta-adrenergic receptor activity(GO:0004939)
0.9 2.6 GO:0002113 interleukin-33 binding(GO:0002113)
0.9 5.1 GO:0004830 tryptophan-tRNA ligase activity(GO:0004830)
0.8 2.4 GO:0005308 creatine transmembrane transporter activity(GO:0005308)
0.6 2.4 GO:0002114 interleukin-33 receptor activity(GO:0002114)
0.6 4.1 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
0.6 12.0 GO:0008430 selenium binding(GO:0008430)
0.6 1.7 GO:0050146 nucleoside phosphotransferase activity(GO:0050146)
0.5 2.4 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
0.2 1.0 GO:0004310 farnesyl-diphosphate farnesyltransferase activity(GO:0004310) squalene synthase activity(GO:0051996)
0.2 0.7 GO:0030626 U12 snRNA binding(GO:0030626)
0.2 3.0 GO:0097016 L27 domain binding(GO:0097016)
0.2 2.6 GO:0031697 beta-1 adrenergic receptor binding(GO:0031697)
0.2 0.6 GO:0033149 FFAT motif binding(GO:0033149)
0.2 1.3 GO:0017050 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.2 0.7 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.2 2.0 GO:0016015 morphogen activity(GO:0016015)
0.2 2.5 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.2 2.4 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.1 0.6 GO:0071987 WD40-repeat domain binding(GO:0071987)
0.1 2.3 GO:0019870 potassium channel inhibitor activity(GO:0019870)
0.1 1.8 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.1 3.2 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.1 0.5 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.1 4.9 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.1 0.5 GO:0070579 methylcytosine dioxygenase activity(GO:0070579)
0.1 2.6 GO:0008494 translation activator activity(GO:0008494)
0.1 0.4 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798)
0.1 0.4 GO:0070538 oleic acid binding(GO:0070538)
0.1 0.6 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.1 4.8 GO:0004385 guanylate kinase activity(GO:0004385)
0.1 3.0 GO:0005328 neurotransmitter:sodium symporter activity(GO:0005328)
0.1 3.1 GO:0002162 dystroglycan binding(GO:0002162)
0.1 0.6 GO:0043532 angiostatin binding(GO:0043532)
0.1 0.3 GO:1904455 ubiquitin-specific protease activity involved in negative regulation of ERAD pathway(GO:1904455)
0.1 2.0 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.1 1.7 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 2.5 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.1 3.5 GO:0015248 sterol transporter activity(GO:0015248)
0.1 2.9 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 0.6 GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517)
0.1 0.8 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.1 1.9 GO:0070411 I-SMAD binding(GO:0070411)
0.1 1.0 GO:0045159 myosin II binding(GO:0045159)
0.1 2.8 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.1 1.1 GO:0034452 dynactin binding(GO:0034452)
0.1 0.7 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
0.1 0.7 GO:0071532 ankyrin repeat binding(GO:0071532)
0.1 2.9 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.1 1.2 GO:0001223 transcription coactivator binding(GO:0001223)
0.1 2.8 GO:0031369 translation initiation factor binding(GO:0031369)
0.1 0.4 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.1 0.4 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.1 1.8 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.0 1.5 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.0 0.9 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.9 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 1.1 GO:0008432 JUN kinase binding(GO:0008432)
0.0 0.8 GO:0048156 tau protein binding(GO:0048156)
0.0 0.8 GO:0032052 bile acid binding(GO:0032052)
0.0 0.5 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.0 8.2 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 3.2 GO:0070888 E-box binding(GO:0070888)
0.0 0.7 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 0.6 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.0 0.9 GO:0008266 poly(U) RNA binding(GO:0008266)
0.0 0.3 GO:0042296 ISG15 transferase activity(GO:0042296)
0.0 0.1 GO:0016230 sphingomyelin phosphodiesterase activator activity(GO:0016230)
0.0 0.3 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
0.0 0.1 GO:0004556 alpha-amylase activity(GO:0004556)
0.0 1.1 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 1.7 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 0.9 GO:0017160 Ral GTPase binding(GO:0017160)
0.0 0.3 GO:0017040 ceramidase activity(GO:0017040)
0.0 4.9 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 2.5 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.2 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.0 0.6 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 1.1 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.5 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.6 GO:0031005 filamin binding(GO:0031005)
0.0 1.2 GO:0032452 histone demethylase activity(GO:0032452)
0.0 3.2 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.0 1.3 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.2 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.0 0.2 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 0.5 GO:0005313 L-glutamate transmembrane transporter activity(GO:0005313) acidic amino acid transmembrane transporter activity(GO:0015172)
0.0 0.6 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.8 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.8 GO:0004407 histone deacetylase activity(GO:0004407)
0.0 0.7 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 0.2 GO:0042731 PH domain binding(GO:0042731)
0.0 0.5 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.0 0.4 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.0 0.2 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 0.1 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.0 0.4 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.0 0.8 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 0.2 GO:0001054 RNA polymerase I activity(GO:0001054)
0.0 2.4 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 0.1 GO:0043533 inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.0 0.4 GO:1990381 ubiquitin-specific protease binding(GO:1990381)
0.0 0.2 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0 3.6 GO:0000287 magnesium ion binding(GO:0000287)
0.0 0.1 GO:0022850 serotonin-gated cation channel activity(GO:0022850)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 8.8 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.2 4.2 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.2 15.7 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 4.9 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.1 12.7 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.1 2.8 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.1 2.9 PID GMCSF PATHWAY GMCSF-mediated signaling events
0.1 6.9 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.1 6.6 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.1 3.0 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.1 3.2 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.1 2.4 PID IL1 PATHWAY IL1-mediated signaling events
0.1 5.6 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 3.0 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 1.0 PID AVB3 OPN PATHWAY Osteopontin-mediated events
0.0 3.9 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.0 5.1 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 1.2 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 2.3 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.0 1.6 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.3 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.0 0.8 PID CONE PATHWAY Visual signal transduction: Cones
0.0 0.7 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.0 2.0 PID CDC42 PATHWAY CDC42 signaling events
0.0 1.9 PID PLK1 PATHWAY PLK1 signaling events
0.0 0.2 PID ERBB1 RECEPTOR PROXIMAL PATHWAY EGF receptor (ErbB1) signaling pathway
0.0 0.5 PID MYC PATHWAY C-MYC pathway
0.0 0.8 PID ARF6 PATHWAY Arf6 signaling events
0.0 1.1 PID PTP1B PATHWAY Signaling events mediated by PTP1B
0.0 0.7 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 0.4 PID ARF 3PATHWAY Arf1 pathway
0.0 1.5 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 0.8 PID TGFBR PATHWAY TGF-beta receptor signaling
0.0 0.7 PID P53 REGULATION PATHWAY p53 pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 7.1 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.1 3.9 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.1 6.3 REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.1 5.1 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.1 3.0 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.1 3.0 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 1.7 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.1 4.1 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.1 1.3 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.1 3.4 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.1 1.7 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.1 2.2 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.1 1.5 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.1 2.1 REACTOME DESTABILIZATION OF MRNA BY KSRP Genes involved in Destabilization of mRNA by KSRP
0.1 1.9 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.1 3.5 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 1.9 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 2.7 REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0 0.9 REACTOME G PROTEIN ACTIVATION Genes involved in G-protein activation
0.0 1.2 REACTOME PIP3 ACTIVATES AKT SIGNALING Genes involved in PIP3 activates AKT signaling
0.0 1.1 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 2.4 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.0 0.5 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 2.8 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 1.9 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 1.1 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.0 1.0 REACTOME GAB1 SIGNALOSOME Genes involved in GAB1 signalosome
0.0 2.0 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.0 3.8 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 1.0 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.6 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 2.5 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 1.7 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.9 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 0.6 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.0 0.9 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation
0.0 1.7 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.4 REACTOME SIGNALLING TO P38 VIA RIT AND RIN Genes involved in Signalling to p38 via RIT and RIN
0.0 1.1 REACTOME SIGNALING BY SCF KIT Genes involved in Signaling by SCF-KIT
0.0 0.4 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 0.7 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.0 1.4 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 0.7 REACTOME REGULATION OF HYPOXIA INDUCIBLE FACTOR HIF BY OXYGEN Genes involved in Regulation of Hypoxia-inducible Factor (HIF) by Oxygen
0.0 0.8 REACTOME G1 PHASE Genes involved in G1 Phase
0.0 1.9 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 0.4 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 0.3 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.0 0.6 REACTOME SIGNALING BY NOTCH1 Genes involved in Signaling by NOTCH1
0.0 0.3 REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
0.0 1.1 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 0.3 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions