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SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for NKX2-3

Z-value: 0.59

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Transcription factors associated with NKX2-3

Gene Symbol Gene ID Gene Info
NKX2-3
ENSG00000119919.9 NK2 homeobox 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NKX2-3hg19_v2_chr10_+_101292684_101292706-0.174.6e-01Click!

Activity profile of NKX2-3 motif

Sorted Z-values of NKX2-3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr5_+_150404904 2.15 ENST00000521632.1
GPX3
glutathione peroxidase 3 (plasma)
chr4_-_90758227 0.88 ENST00000506691.1
ENST00000394986.1
ENST00000506244.1
ENST00000394989.2
ENST00000394991.3
SNCA
synuclein, alpha (non A4 component of amyloid precursor)
chr11_+_35211511 0.87 ENST00000524922.1
CD44
CD44 molecule (Indian blood group)
chr12_-_123201337 0.84 ENST00000528880.2
HCAR3
hydroxycarboxylic acid receptor 3
chr1_+_35220613 0.78 ENST00000338513.1
GJB5
gap junction protein, beta 5, 31.1kDa
chr5_+_179105615 0.76 ENST00000514383.1
CANX
calnexin
chr17_+_66521936 0.76 ENST00000592800.1
PRKAR1A
protein kinase, cAMP-dependent, regulatory, type I, alpha
chr12_-_123187890 0.75 ENST00000328880.5
HCAR2
hydroxycarboxylic acid receptor 2
chr18_-_33702078 0.74 ENST00000586829.1
SLC39A6
solute carrier family 39 (zinc transporter), member 6
chr18_-_74839891 0.72 ENST00000581878.1
MBP
myelin basic protein
chr16_-_69166031 0.70 ENST00000398235.2
ENST00000520529.1
CHTF8
CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae)
chr7_-_2883650 0.69 ENST00000544127.1
GNA12
guanine nucleotide binding protein (G protein) alpha 12
chr18_+_72166564 0.69 ENST00000583216.1
ENST00000581912.1
ENST00000582589.1
CNDP2
CNDP dipeptidase 2 (metallopeptidase M20 family)
chr7_-_80548493 0.69 ENST00000536800.1
SEMA3C
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr19_-_51504852 0.67 ENST00000391806.2
ENST00000347619.4
ENST00000291726.7
ENST00000320838.5
KLK8
kallikrein-related peptidase 8
chr17_+_26662679 0.67 ENST00000578158.1
TNFAIP1
tumor necrosis factor, alpha-induced protein 1 (endothelial)
chr9_+_131447342 0.67 ENST00000409104.3
SET
SET nuclear oncogene
chr19_+_7445850 0.66 ENST00000593531.1
CTD-2207O23.3
Rho guanine nucleotide exchange factor 18
chr10_-_32345305 0.64 ENST00000302418.4
KIF5B
kinesin family member 5B
chr3_-_69062790 0.63 ENST00000540955.1
ENST00000456376.1
EOGT
EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase
chr7_-_80548667 0.63 ENST00000265361.3
SEMA3C
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr3_+_113775594 0.62 ENST00000479882.1
ENST00000493014.1
QTRTD1
queuine tRNA-ribosyltransferase domain containing 1
chr11_+_35211429 0.62 ENST00000525688.1
ENST00000278385.6
ENST00000533222.1
CD44
CD44 molecule (Indian blood group)
chr1_+_230193521 0.62 ENST00000543760.1
GALNT2
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2)
chr2_+_64073187 0.62 ENST00000491621.1
UGP2
UDP-glucose pyrophosphorylase 2
chr5_-_159846066 0.61 ENST00000519349.1
ENST00000520664.1
SLU7
SLU7 splicing factor homolog (S. cerevisiae)
chrX_+_114795489 0.61 ENST00000355899.3
ENST00000537301.1
ENST00000289290.3
PLS3
plastin 3
chr14_-_69262947 0.59 ENST00000557086.1
ZFP36L1
ZFP36 ring finger protein-like 1
chr6_-_26216872 0.59 ENST00000244601.3
HIST1H2BG
histone cluster 1, H2bg
chr4_-_85654615 0.58 ENST00000514711.1
WDFY3
WD repeat and FYVE domain containing 3
chr10_+_101419187 0.57 ENST00000370489.4
ENTPD7
ectonucleoside triphosphate diphosphohydrolase 7
chr2_-_178128528 0.57 ENST00000397063.4
ENST00000421929.1
NFE2L2
nuclear factor, erythroid 2-like 2
chr4_+_48343339 0.57 ENST00000264313.6
SLAIN2
SLAIN motif family, member 2
chr17_-_80797886 0.55 ENST00000572562.1
ZNF750
zinc finger protein 750
chr17_+_75401152 0.54 ENST00000585930.1
SEPT9
septin 9
chr12_+_41136144 0.54 ENST00000548005.1
ENST00000552248.1
CNTN1
contactin 1
chr5_-_142814241 0.53 ENST00000504572.1
NR3C1
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr7_+_56032652 0.52 ENST00000437587.1
GBAS
glioblastoma amplified sequence
chr8_-_49834299 0.52 ENST00000396822.1
SNAI2
snail family zinc finger 2
chr17_-_8059638 0.51 ENST00000584202.1
ENST00000354903.5
ENST00000577253.1
PER1
period circadian clock 1
chrX_+_153029633 0.51 ENST00000538966.1
ENST00000361971.5
ENST00000538776.1
ENST00000538543.1
PLXNB3
plexin B3
chr11_+_57435441 0.50 ENST00000528177.1
ZDHHC5
zinc finger, DHHC-type containing 5
chr6_-_32634425 0.50 ENST00000399082.3
ENST00000399079.3
ENST00000374943.4
ENST00000434651.2
HLA-DQB1
major histocompatibility complex, class II, DQ beta 1
chr10_+_116697946 0.50 ENST00000298746.3
TRUB1
TruB pseudouridine (psi) synthase family member 1
chr7_-_38948774 0.50 ENST00000395969.2
ENST00000414632.1
ENST00000310301.4
VPS41
vacuolar protein sorting 41 homolog (S. cerevisiae)
chr7_-_130353553 0.50 ENST00000330992.7
ENST00000445977.2
COPG2
coatomer protein complex, subunit gamma 2
chr9_+_71820057 0.50 ENST00000539225.1
TJP2
tight junction protein 2
chr1_-_46642154 0.49 ENST00000540385.1
PIK3R3
phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
chr11_+_64950801 0.48 ENST00000526468.1
CAPN1
calpain 1, (mu/I) large subunit
chr1_-_31538517 0.48 ENST00000440538.2
ENST00000423018.2
ENST00000424085.2
ENST00000426105.2
ENST00000257075.5
ENST00000373747.3
ENST00000525843.1
ENST00000373742.2
PUM1
pumilio RNA-binding family member 1
chr2_-_37501692 0.47 ENST00000443977.1
PRKD3
protein kinase D3
chr5_+_138210919 0.47 ENST00000522013.1
ENST00000520260.1
ENST00000523298.1
ENST00000520865.1
ENST00000519634.1
ENST00000517533.1
ENST00000523685.1
ENST00000519768.1
ENST00000517656.1
ENST00000521683.1
ENST00000521640.1
ENST00000519116.1
CTNNA1
catenin (cadherin-associated protein), alpha 1, 102kDa
chr8_-_49833978 0.47 ENST00000020945.1
SNAI2
snail family zinc finger 2
chr22_-_30814469 0.47 ENST00000598426.1
KIAA1658
KIAA1658
chr12_+_14572070 0.47 ENST00000545769.1
ENST00000428217.2
ENST00000396279.2
ENST00000542514.1
ENST00000536279.1
ATF7IP
activating transcription factor 7 interacting protein
chr11_+_33563618 0.46 ENST00000526400.1
KIAA1549L
KIAA1549-like
chr6_-_111927062 0.46 ENST00000359831.4
TRAF3IP2
TRAF3 interacting protein 2
chr18_-_43684230 0.46 ENST00000592989.1
ENST00000589869.1
ATP5A1
ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
chr9_+_71819927 0.46 ENST00000535702.1
TJP2
tight junction protein 2
chr13_-_30881134 0.45 ENST00000380617.3
ENST00000441394.1
KATNAL1
katanin p60 subunit A-like 1
chr3_+_186743261 0.44 ENST00000423451.1
ENST00000446170.1
ST6GAL1
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chr1_-_35325318 0.44 ENST00000423898.1
ENST00000456842.1
SMIM12
small integral membrane protein 12
chr7_+_134430212 0.43 ENST00000436461.2
CALD1
caldesmon 1
chr5_-_110848253 0.43 ENST00000505803.1
ENST00000502322.1
STARD4
StAR-related lipid transfer (START) domain containing 4
chr2_-_31440377 0.43 ENST00000444918.2
ENST00000403897.3
CAPN14
calpain 14
chr4_-_90757364 0.43 ENST00000508895.1
SNCA
synuclein, alpha (non A4 component of amyloid precursor)
chr3_-_69062742 0.42 ENST00000424374.1
EOGT
EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase
chrX_-_108976410 0.42 ENST00000504980.1
ACSL4
acyl-CoA synthetase long-chain family member 4
chr2_+_201170596 0.42 ENST00000439084.1
ENST00000409718.1
SPATS2L
spermatogenesis associated, serine-rich 2-like
chr4_+_146403912 0.41 ENST00000507367.1
ENST00000394092.2
ENST00000515385.1
SMAD1
SMAD family member 1
chr4_-_90758118 0.41 ENST00000420646.2
SNCA
synuclein, alpha (non A4 component of amyloid precursor)
chr14_+_64565442 0.41 ENST00000553308.1
SYNE2
spectrin repeat containing, nuclear envelope 2
chr14_-_91720224 0.40 ENST00000238699.3
ENST00000531499.2
GPR68
G protein-coupled receptor 68
chr2_-_172291273 0.39 ENST00000442778.1
ENST00000453846.1
METTL8
methyltransferase like 8
chr15_+_40674920 0.38 ENST00000416151.2
ENST00000249776.8
KNSTRN
kinetochore-localized astrin/SPAG5 binding protein
chr12_-_123565834 0.38 ENST00000546049.1
PITPNM2
phosphatidylinositol transfer protein, membrane-associated 2
chrX_+_69509870 0.38 ENST00000374388.3
KIF4A
kinesin family member 4A
chr16_-_18911366 0.38 ENST00000565224.1
SMG1
SMG1 phosphatidylinositol 3-kinase-related kinase
chr3_-_122233723 0.38 ENST00000493510.1
ENST00000344337.6
ENST00000476916.1
ENST00000465882.1
KPNA1
karyopherin alpha 1 (importin alpha 5)
chr5_+_108083517 0.37 ENST00000281092.4
ENST00000536402.1
FER
fer (fps/fes related) tyrosine kinase
chr2_-_38303218 0.37 ENST00000407341.1
ENST00000260630.3
CYP1B1
cytochrome P450, family 1, subfamily B, polypeptide 1
chr3_-_123512688 0.36 ENST00000475616.1
MYLK
myosin light chain kinase
chr2_+_172309634 0.36 ENST00000339506.3
DCAF17
DDB1 and CUL4 associated factor 17
chr10_+_1120312 0.36 ENST00000436154.1
WDR37
WD repeat domain 37
chr2_+_64069240 0.35 ENST00000497883.1
UGP2
UDP-glucose pyrophosphorylase 2
chr3_+_182971018 0.35 ENST00000326505.3
B3GNT5
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
chr3_+_30647994 0.35 ENST00000295754.5
TGFBR2
transforming growth factor, beta receptor II (70/80kDa)
chrX_-_134049233 0.35 ENST00000370779.4
MOSPD1
motile sperm domain containing 1
chrX_+_9502971 0.35 ENST00000452824.1
TBL1X
transducin (beta)-like 1X-linked
chr10_+_99332198 0.35 ENST00000307518.5
ENST00000298808.5
ENST00000370655.1
ANKRD2
ankyrin repeat domain 2 (stretch responsive muscle)
chr14_+_36295638 0.34 ENST00000543183.1
BRMS1L
breast cancer metastasis-suppressor 1-like
chr17_+_26662597 0.34 ENST00000544907.2
TNFAIP1
tumor necrosis factor, alpha-induced protein 1 (endothelial)
chr14_+_100531738 0.33 ENST00000555706.1
EVL
Enah/Vasp-like
chr4_-_36246060 0.33 ENST00000303965.4
ARAP2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr2_+_71357744 0.33 ENST00000498451.2
MPHOSPH10
M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein)
chr3_-_69062764 0.32 ENST00000295571.5
EOGT
EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase
chr6_-_32160622 0.32 ENST00000487761.1
ENST00000375040.3
GPSM3
G-protein signaling modulator 3
chr8_-_99954788 0.32 ENST00000523601.1
STK3
serine/threonine kinase 3
chr5_+_49961727 0.32 ENST00000505697.2
ENST00000503750.2
ENST00000514342.2
PARP8
poly (ADP-ribose) polymerase family, member 8
chr2_+_64069016 0.31 ENST00000488245.2
UGP2
UDP-glucose pyrophosphorylase 2
chr15_-_78369994 0.31 ENST00000300584.3
ENST00000409931.3
TBC1D2B
TBC1 domain family, member 2B
chr22_+_21213771 0.31 ENST00000439214.1
SNAP29
synaptosomal-associated protein, 29kDa
chr10_-_104262460 0.31 ENST00000446605.2
ENST00000369905.4
ENST00000545684.1
ACTR1A
ARP1 actin-related protein 1 homolog A, centractin alpha (yeast)
chr7_+_7196565 0.31 ENST00000429911.1
C1GALT1
core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1
chr1_-_89488510 0.31 ENST00000564665.1
ENST00000370481.4
GBP3
guanylate binding protein 3
chr10_+_13203543 0.30 ENST00000378714.3
ENST00000479669.1
ENST00000484800.2
MCM10
minichromosome maintenance complex component 10
chr1_+_174670143 0.30 ENST00000367687.1
ENST00000347255.2
RABGAP1L
RAB GTPase activating protein 1-like
chr1_-_68962805 0.30 ENST00000370966.5
DEPDC1
DEP domain containing 1
chr9_+_131644398 0.30 ENST00000372599.3
LRRC8A
leucine rich repeat containing 8 family, member A
chr2_+_219110149 0.30 ENST00000456575.1
ARPC2
actin related protein 2/3 complex, subunit 2, 34kDa
chr19_+_45409011 0.30 ENST00000252486.4
ENST00000446996.1
ENST00000434152.1
APOE
apolipoprotein E
chr1_-_232598163 0.29 ENST00000308942.4
SIPA1L2
signal-induced proliferation-associated 1 like 2
chr1_-_200379104 0.29 ENST00000367352.3
ZNF281
zinc finger protein 281
chr1_+_65613340 0.29 ENST00000546702.1
AK4
adenylate kinase 4
chr19_+_53761545 0.28 ENST00000341702.3
VN1R2
vomeronasal 1 receptor 2
chr10_-_36813162 0.28 ENST00000440465.1
NAMPTL
nicotinamide phosphoribosyltransferase-like
chr3_+_101818088 0.28 ENST00000491959.1
ZPLD1
zona pellucida-like domain containing 1
chr9_+_131644388 0.28 ENST00000372600.4
LRRC8A
leucine rich repeat containing 8 family, member A
chr15_+_40674963 0.27 ENST00000448395.2
KNSTRN
kinetochore-localized astrin/SPAG5 binding protein
chr17_-_8055747 0.27 ENST00000317276.4
ENST00000581703.1
PER1
period circadian clock 1
chr13_-_30880979 0.27 ENST00000414289.1
KATNAL1
katanin p60 subunit A-like 1
chr10_-_73976884 0.27 ENST00000317126.4
ENST00000545550.1
ASCC1
activating signal cointegrator 1 complex subunit 1
chr16_-_58663720 0.27 ENST00000564557.1
ENST00000569240.1
ENST00000441024.2
ENST00000569020.1
ENST00000317147.5
CNOT1
CCR4-NOT transcription complex, subunit 1
chr3_+_39093481 0.26 ENST00000302313.5
ENST00000544962.1
ENST00000396258.3
ENST00000418020.1
WDR48
WD repeat domain 48
chr2_+_232135245 0.26 ENST00000446447.1
ARMC9
armadillo repeat containing 9
chr18_-_43684186 0.26 ENST00000590406.1
ENST00000282050.2
ENST00000590324.1
ATP5A1
ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
chr4_-_39034542 0.26 ENST00000344606.6
TMEM156
transmembrane protein 156
chr19_+_14492217 0.26 ENST00000587606.1
ENST00000586517.1
ENST00000591080.1
CD97
CD97 molecule
chr2_+_64068844 0.25 ENST00000337130.5
UGP2
UDP-glucose pyrophosphorylase 2
chr4_-_141677267 0.25 ENST00000442267.2
TBC1D9
TBC1 domain family, member 9 (with GRAM domain)
chr1_-_35325400 0.25 ENST00000521580.2
SMIM12
small integral membrane protein 12
chrX_-_40036520 0.25 ENST00000406200.2
ENST00000378455.4
ENST00000342274.4
BCOR
BCL6 corepressor
chr11_-_71752838 0.25 ENST00000537930.1
NUMA1
nuclear mitotic apparatus protein 1
chr11_+_7595136 0.24 ENST00000529575.1
PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr12_+_6309963 0.24 ENST00000382515.2
CD9
CD9 molecule
chr8_+_75262629 0.24 ENST00000434412.2
GDAP1
ganglioside induced differentiation associated protein 1
chr10_+_129785536 0.24 ENST00000419012.2
PTPRE
protein tyrosine phosphatase, receptor type, E
chr14_-_94547541 0.24 ENST00000544005.1
ENST00000555054.1
ENST00000330836.5
DDX24
DEAD (Asp-Glu-Ala-Asp) box helicase 24
chr2_+_64069459 0.24 ENST00000445915.2
ENST00000475462.1
UGP2
UDP-glucose pyrophosphorylase 2
chr5_-_39270725 0.24 ENST00000512138.1
ENST00000512982.1
ENST00000540520.1
FYB
FYN binding protein
chr10_-_104913367 0.24 ENST00000423468.2
NT5C2
5'-nucleotidase, cytosolic II
chr8_-_135652051 0.24 ENST00000522257.1
ZFAT
zinc finger and AT hook domain containing
chr19_-_10341948 0.24 ENST00000590320.1
ENST00000592342.1
ENST00000588952.1
S1PR2
DNMT1
sphingosine-1-phosphate receptor 2
DNA (cytosine-5-)-methyltransferase 1
chr10_-_27529486 0.23 ENST00000375888.1
ACBD5
acyl-CoA binding domain containing 5
chr1_+_46806452 0.23 ENST00000536062.1
NSUN4
NOP2/Sun domain family, member 4
chr13_-_50018241 0.23 ENST00000409308.1
CAB39L
calcium binding protein 39-like
chr12_+_12966250 0.23 ENST00000352940.4
ENST00000358007.3
ENST00000544400.1
DDX47
DEAD (Asp-Glu-Ala-Asp) box polypeptide 47
chr11_+_12399071 0.23 ENST00000539723.1
ENST00000550549.1
PARVA
parvin, alpha
chr10_+_27793197 0.23 ENST00000356940.6
ENST00000535776.1
RAB18
RAB18, member RAS oncogene family
chr3_+_30648066 0.22 ENST00000359013.4
TGFBR2
transforming growth factor, beta receptor II (70/80kDa)
chr1_+_110091189 0.22 ENST00000369851.4
GNAI3
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
chr2_-_36825281 0.22 ENST00000405912.3
ENST00000379245.4
FEZ2
fasciculation and elongation protein zeta 2 (zygin II)
chr13_-_50018140 0.22 ENST00000410043.1
ENST00000347776.5
CAB39L
calcium binding protein 39-like
chr1_+_46806837 0.22 ENST00000537428.1
NSUN4
NOP2/Sun domain family, member 4
chrX_+_109602039 0.22 ENST00000520821.1
RGAG1
retrotransposon gag domain containing 1
chrX_+_37865804 0.22 ENST00000297875.2
ENST00000357972.5
SYTL5
synaptotagmin-like 5
chr2_-_54197915 0.21 ENST00000404125.1
PSME4
proteasome (prosome, macropain) activator subunit 4
chr10_+_99332529 0.21 ENST00000455090.1
ANKRD2
ankyrin repeat domain 2 (stretch responsive muscle)
chr4_+_144303093 0.21 ENST00000505913.1
GAB1
GRB2-associated binding protein 1
chr15_+_43477455 0.21 ENST00000300213.4
CCNDBP1
cyclin D-type binding-protein 1
chr14_-_23762777 0.20 ENST00000431326.2
HOMEZ
homeobox and leucine zipper encoding
chr12_+_19389814 0.20 ENST00000536974.1
PLEKHA5
pleckstrin homology domain containing, family A member 5
chr10_+_129785574 0.20 ENST00000430713.2
ENST00000471218.1
PTPRE
protein tyrosine phosphatase, receptor type, E
chr19_+_14491948 0.20 ENST00000358600.3
CD97
CD97 molecule
chr2_+_102803433 0.19 ENST00000264257.2
ENST00000441515.2
IL1RL2
interleukin 1 receptor-like 2
chr15_+_43477580 0.19 ENST00000356633.5
CCNDBP1
cyclin D-type binding-protein 1
chr3_-_42623805 0.19 ENST00000456515.1
SEC22C
SEC22 vesicle trafficking protein homolog C (S. cerevisiae)
chr1_+_174669653 0.19 ENST00000325589.5
RABGAP1L
RAB GTPase activating protein 1-like
chrX_-_16730984 0.19 ENST00000380241.3
CTPS2
CTP synthase 2
chr1_+_109632425 0.19 ENST00000338272.8
TMEM167B
transmembrane protein 167B
chr11_+_11863500 0.19 ENST00000527733.1
ENST00000539466.1
USP47
ubiquitin specific peptidase 47
chr14_+_36295504 0.18 ENST00000216807.7
BRMS1L
breast cancer metastasis-suppressor 1-like
chr1_+_40839369 0.18 ENST00000372718.3
SMAP2
small ArfGAP2
chr11_-_71753188 0.18 ENST00000543009.1
NUMA1
nuclear mitotic apparatus protein 1
chr19_-_19051993 0.18 ENST00000594794.1
ENST00000355887.6
ENST00000392351.3
ENST00000596482.1
HOMER3
homer homolog 3 (Drosophila)
chr2_+_161993465 0.18 ENST00000457476.1
TANK
TRAF family member-associated NFKB activator
chrX_-_32173579 0.18 ENST00000359836.1
ENST00000343523.2
ENST00000378707.3
ENST00000541735.1
ENST00000474231.1
DMD
dystrophin
chr3_+_183892635 0.17 ENST00000427072.1
ENST00000411763.2
ENST00000292807.5
ENST00000448139.1
ENST00000455925.1
AP2M1
adaptor-related protein complex 2, mu 1 subunit
chr16_+_68877496 0.17 ENST00000261778.1
TANGO6
transport and golgi organization 6 homolog (Drosophila)
chr5_-_42887494 0.17 ENST00000514218.1
SEPP1
selenoprotein P, plasma, 1
chr2_+_114163945 0.17 ENST00000453673.3
IGKV1OR2-108
immunoglobulin kappa variable 1/OR2-108 (non-functional)
chr15_+_33022885 0.17 ENST00000322805.4
GREM1
gremlin 1, DAN family BMP antagonist
chr10_+_3146868 0.17 ENST00000415005.1
ENST00000468050.1
PFKP
phosphofructokinase, platelet
chr1_-_182573514 0.17 ENST00000367558.5
RGS16
regulator of G-protein signaling 16
chr6_+_46761118 0.17 ENST00000230588.4
MEP1A
meprin A, alpha (PABA peptide hydrolase)
chr6_-_150212029 0.16 ENST00000529948.1
ENST00000357183.4
ENST00000367363.3
RAET1E
retinoic acid early transcript 1E
chr3_+_38179969 0.16 ENST00000396334.3
ENST00000417037.2
ENST00000424893.1
ENST00000495303.1
ENST00000443433.2
ENST00000421516.1
MYD88
myeloid differentiation primary response 88
chr6_-_33239712 0.16 ENST00000436044.2
VPS52
vacuolar protein sorting 52 homolog (S. cerevisiae)
chr19_+_50084561 0.16 ENST00000246794.5
PRRG2
proline rich Gla (G-carboxyglutamic acid) 2
chr14_+_55494323 0.16 ENST00000339298.2
SOCS4
suppressor of cytokine signaling 4
chr14_+_67831576 0.16 ENST00000555876.1
EIF2S1
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
chr20_+_56964169 0.16 ENST00000475243.1
VAPB
VAMP (vesicle-associated membrane protein)-associated protein B and C
chr16_+_56969284 0.16 ENST00000568358.1
HERPUD1
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr22_+_45714301 0.16 ENST00000427777.1
FAM118A
family with sequence similarity 118, member A
chr10_+_16478942 0.16 ENST00000535784.2
ENST00000423462.2
ENST00000378000.1
PTER
phosphotriesterase related
chr12_-_122018859 0.16 ENST00000536437.1
ENST00000377071.4
ENST00000538046.2
KDM2B
lysine (K)-specific demethylase 2B
chr3_+_190105909 0.16 ENST00000456423.1
CLDN16
claudin 16
chr15_-_99791413 0.15 ENST00000394129.2
ENST00000558663.1
ENST00000394135.3
ENST00000561365.1
ENST00000560279.1
TTC23
tetratricopeptide repeat domain 23
chr1_+_152730499 0.15 ENST00000368773.1
KPRP
keratinocyte proline-rich protein
chr9_+_135906076 0.15 ENST00000372097.5
ENST00000440319.1
GTF3C5
general transcription factor IIIC, polypeptide 5, 63kDa

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX2-3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.7 GO:0051620 negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) positive regulation of peroxidase activity(GO:2000470)
0.3 1.0 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
0.3 2.1 GO:0006982 response to lipid hydroperoxide(GO:0006982)
0.3 0.9 GO:0010877 lipid transport involved in lipid storage(GO:0010877)
0.2 1.8 GO:0019255 glucose 1-phosphate metabolic process(GO:0019255)
0.2 0.6 GO:0002661 B cell tolerance induction(GO:0002514) regulation of B cell tolerance induction(GO:0002661) positive regulation of B cell tolerance induction(GO:0002663)
0.2 1.5 GO:1900625 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.2 0.8 GO:0060708 spongiotrophoblast differentiation(GO:0060708)
0.1 0.6 GO:0035617 stress granule disassembly(GO:0035617)
0.1 0.5 GO:0042144 vacuole fusion, non-autophagic(GO:0042144)
0.1 0.4 GO:0050904 response to stem cell factor(GO:0036215) cellular response to stem cell factor stimulus(GO:0036216) Kit signaling pathway(GO:0038109) diapedesis(GO:0050904)
0.1 0.7 GO:0033031 positive regulation of neutrophil apoptotic process(GO:0033031)
0.1 0.7 GO:1904209 regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209)
0.1 1.3 GO:0003350 pulmonary myocardium development(GO:0003350)
0.1 0.6 GO:0002378 immunoglobulin biosynthetic process(GO:0002378)
0.1 0.8 GO:2000323 negative regulation of glucocorticoid receptor signaling pathway(GO:2000323)
0.1 0.7 GO:0031642 negative regulation of myelination(GO:0031642)
0.1 1.0 GO:0071847 TNFSF11-mediated signaling pathway(GO:0071847)
0.1 0.5 GO:2001045 negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.1 0.4 GO:0061304 retinal blood vessel morphogenesis(GO:0061304)
0.1 0.2 GO:0048611 ectodermal digestive tract development(GO:0007439) embryonic ectodermal digestive tract development(GO:0048611)
0.1 0.6 GO:1903788 mycotoxin catabolic process(GO:0043387) aflatoxin catabolic process(GO:0046223) organic heteropentacyclic compound catabolic process(GO:1901377) regulation of glutathione biosynthetic process(GO:1903786) positive regulation of glutathione biosynthetic process(GO:1903788)
0.1 0.3 GO:0016267 O-glycan processing, core 1(GO:0016267)
0.1 0.7 GO:0051013 microtubule severing(GO:0051013)
0.1 0.5 GO:1990481 mRNA pseudouridine synthesis(GO:1990481)
0.1 0.8 GO:0035973 aggrephagy(GO:0035973)
0.1 0.2 GO:0000415 negative regulation of histone H3-K36 methylation(GO:0000415)
0.1 0.3 GO:0016240 autophagosome docking(GO:0016240)
0.1 0.2 GO:0032747 positive regulation of interleukin-23 production(GO:0032747)
0.1 0.2 GO:1990737 response to manganese-induced endoplasmic reticulum stress(GO:1990737)
0.1 0.5 GO:0089700 protein kinase D signaling(GO:0089700)
0.1 0.6 GO:0002329 pre-B cell differentiation(GO:0002329)
0.1 0.2 GO:0070898 RNA polymerase III transcriptional preinitiation complex assembly(GO:0070898)
0.1 0.4 GO:2001206 positive regulation of osteoclast development(GO:2001206)
0.1 0.5 GO:0042256 mature ribosome assembly(GO:0042256)
0.0 0.5 GO:0000389 mRNA 3'-splice site recognition(GO:0000389)
0.0 0.3 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.0 0.1 GO:0032290 peripheral nervous system myelin formation(GO:0032290)
0.0 0.6 GO:2000291 regulation of myoblast proliferation(GO:2000291)
0.0 0.1 GO:1903598 positive regulation of gap junction assembly(GO:1903598)
0.0 0.5 GO:0010593 negative regulation of lamellipodium assembly(GO:0010593)
0.0 0.1 GO:0033037 polysaccharide localization(GO:0033037)
0.0 0.4 GO:0031022 nuclear migration along microfilament(GO:0031022)
0.0 0.4 GO:0060136 embryonic process involved in female pregnancy(GO:0060136)
0.0 0.4 GO:1902365 regulation of spindle elongation(GO:0032887) regulation of mitotic spindle elongation(GO:0032888) anastral spindle assembly(GO:0055048) protein localization to spindle pole body(GO:0071988) regulation of protein localization to spindle pole body(GO:1902363) positive regulation of protein localization to spindle pole body(GO:1902365) positive regulation of mitotic spindle elongation(GO:1902846)
0.0 0.2 GO:1900154 regulation of bone trabecula formation(GO:1900154) negative regulation of bone trabecula formation(GO:1900155)
0.0 0.4 GO:0046940 nucleoside monophosphate phosphorylation(GO:0046940)
0.0 0.4 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.0 0.5 GO:1900246 positive regulation of RIG-I signaling pathway(GO:1900246)
0.0 0.2 GO:0044210 'de novo' CTP biosynthetic process(GO:0044210)
0.0 0.7 GO:0071578 zinc II ion transmembrane import(GO:0071578)
0.0 0.8 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.0 0.8 GO:0045835 negative regulation of meiotic nuclear division(GO:0045835)
0.0 0.5 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
0.0 0.3 GO:0019236 response to pheromone(GO:0019236)
0.0 0.8 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.0 0.3 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.0 0.4 GO:0002051 osteoblast fate commitment(GO:0002051)
0.0 0.2 GO:0090116 C-5 methylation of cytosine(GO:0090116)
0.0 0.2 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.0 0.3 GO:1902525 regulation of protein monoubiquitination(GO:1902525)
0.0 0.7 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.0 0.5 GO:0060056 mammary gland involution(GO:0060056)
0.0 0.8 GO:0051639 actin filament network formation(GO:0051639)
0.0 1.0 GO:0035024 negative regulation of Rho protein signal transduction(GO:0035024)
0.0 0.1 GO:1904117 response to vasopressin(GO:1904116) cellular response to vasopressin(GO:1904117)
0.0 0.2 GO:0021993 initiation of neural tube closure(GO:0021993)
0.0 0.3 GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
0.0 0.6 GO:0034656 nucleobase-containing small molecule catabolic process(GO:0034656)
0.0 0.6 GO:0006750 glutathione biosynthetic process(GO:0006750)
0.0 0.4 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.0 0.1 GO:0051490 negative regulation of filopodium assembly(GO:0051490)
0.0 0.7 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.0 0.2 GO:0035520 monoubiquitinated protein deubiquitination(GO:0035520)
0.0 0.2 GO:0009414 response to water deprivation(GO:0009414)
0.0 0.1 GO:0001951 intestinal D-glucose absorption(GO:0001951)
0.0 0.1 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
0.0 0.3 GO:1900017 positive regulation of cytokine production involved in inflammatory response(GO:1900017)
0.0 0.2 GO:1903071 positive regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903071)
0.0 0.2 GO:0006987 activation of signaling protein activity involved in unfolded protein response(GO:0006987)
0.0 0.3 GO:0006307 DNA dealkylation involved in DNA repair(GO:0006307)
0.0 0.4 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.0 0.0 GO:0071963 establishment or maintenance of cell polarity regulating cell shape(GO:0071963)
0.0 0.1 GO:0072369 regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369)
0.0 0.1 GO:2000691 regulation of cardiac muscle cell myoblast differentiation(GO:2000690) negative regulation of cardiac muscle cell myoblast differentiation(GO:2000691)
0.0 0.5 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.0 0.5 GO:0001783 B cell apoptotic process(GO:0001783)
0.0 0.2 GO:0046085 adenosine metabolic process(GO:0046085)
0.0 0.2 GO:0071670 smooth muscle cell chemotaxis(GO:0071670)
0.0 0.2 GO:1900028 negative regulation of ruffle assembly(GO:1900028)
0.0 0.6 GO:0031116 positive regulation of microtubule polymerization(GO:0031116)
0.0 0.2 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.0 0.2 GO:1902902 negative regulation of autophagosome assembly(GO:1902902)
0.0 0.5 GO:0000470 maturation of LSU-rRNA(GO:0000470)
0.0 0.1 GO:0000117 regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0000117)
0.0 0.2 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.0 0.1 GO:0070980 biphenyl catabolic process(GO:0070980)
0.0 0.1 GO:0046373 arabinose metabolic process(GO:0019566) L-arabinose metabolic process(GO:0046373)
0.0 0.1 GO:0051012 microtubule sliding(GO:0051012)
0.0 0.3 GO:0010592 positive regulation of lamellipodium assembly(GO:0010592)
0.0 0.1 GO:0070475 rRNA base methylation(GO:0070475)
0.0 0.5 GO:2001275 positive regulation of glucose import in response to insulin stimulus(GO:2001275)
0.0 0.4 GO:0006309 apoptotic DNA fragmentation(GO:0006309)
0.0 0.9 GO:0010762 regulation of fibroblast migration(GO:0010762)
0.0 0.1 GO:0019249 regulation of amino acid import(GO:0010958) lactate biosynthetic process(GO:0019249) regulation of amino acid uptake involved in synaptic transmission(GO:0051941) regulation of glutamate uptake involved in transmission of nerve impulse(GO:0051946) regulation of L-glutamate import(GO:1900920)
0.0 0.1 GO:0060005 vestibular reflex(GO:0060005)
0.0 0.1 GO:0097411 hypoxia-inducible factor-1alpha signaling pathway(GO:0097411)
0.0 0.3 GO:0071305 cellular response to vitamin D(GO:0071305)
0.0 0.1 GO:1901545 cellular response to raffinose(GO:0097403) response to raffinose(GO:1901545)
0.0 0.0 GO:0090472 viral protein processing(GO:0019082) regulation of nerve growth factor production(GO:0032903) negative regulation of nerve growth factor production(GO:0032904) dibasic protein processing(GO:0090472)
0.0 0.1 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.0 1.7 GO:0006493 protein O-linked glycosylation(GO:0006493)
0.0 0.3 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0 0.3 GO:0006337 nucleosome disassembly(GO:0006337)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.5 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.1 0.6 GO:0097635 extrinsic component of autophagosome membrane(GO:0097635)
0.1 0.3 GO:0036194 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.1 0.3 GO:0034365 discoidal high-density lipoprotein particle(GO:0034365)
0.1 0.7 GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.1 1.2 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.1 0.3 GO:0034457 Mpp10 complex(GO:0034457)
0.1 0.1 GO:0034274 Atg12-Atg5-Atg16 complex(GO:0034274)
0.1 0.2 GO:1990745 EARP complex(GO:1990745)
0.1 0.7 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.1 0.2 GO:0043614 multi-eIF complex(GO:0043614) translation preinitiation complex(GO:0070993) glial limiting end-foot(GO:0097451)
0.1 0.6 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.1 0.3 GO:0020016 ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018)
0.1 0.5 GO:0033263 CORVET complex(GO:0033263)
0.0 0.7 GO:0033269 internode region of axon(GO:0033269)
0.0 2.0 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.4 GO:0070545 PeBoW complex(GO:0070545)
0.0 0.4 GO:0055028 cortical microtubule(GO:0055028)
0.0 0.3 GO:0002177 manchette(GO:0002177)
0.0 0.6 GO:0035253 ciliary rootlet(GO:0035253)
0.0 0.6 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 0.4 GO:0031298 replication fork protection complex(GO:0031298)
0.0 0.8 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 0.4 GO:0030478 actin cap(GO:0030478)
0.0 0.8 GO:0005922 connexon complex(GO:0005922)
0.0 1.2 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 0.5 GO:0016600 flotillin complex(GO:0016600)
0.0 1.2 GO:0035371 microtubule plus-end(GO:0035371)
0.0 0.2 GO:1990111 spermatoproteasome complex(GO:1990111)
0.0 0.2 GO:1990037 Lewy body core(GO:1990037)
0.0 0.1 GO:0048269 methionine adenosyltransferase complex(GO:0048269)
0.0 0.1 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.0 0.3 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 0.2 GO:0016013 syntrophin complex(GO:0016013)
0.0 0.4 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 0.2 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.0 0.1 GO:0071203 WASH complex(GO:0071203)
0.0 0.5 GO:0031105 septin complex(GO:0031105)
0.0 0.5 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 1.0 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.4 GO:0071141 SMAD protein complex(GO:0071141)
0.0 0.5 GO:0070822 Sin3-type complex(GO:0070822)
0.0 0.1 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.0 0.3 GO:0031332 RISC complex(GO:0016442) RNAi effector complex(GO:0031332)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.7 GO:0060961 phospholipase D inhibitor activity(GO:0060961)
0.3 1.8 GO:0051748 UTP:glucose-1-phosphate uridylyltransferase activity(GO:0003983) UTP-monosaccharide-1-phosphate uridylyltransferase activity(GO:0051748)
0.2 1.4 GO:0016262 protein N-acetylglucosaminyltransferase activity(GO:0016262)
0.2 0.6 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.2 0.6 GO:0099609 microtubule lateral binding(GO:0099609)
0.1 0.6 GO:0005026 transforming growth factor beta receptor activity, type II(GO:0005026)
0.1 0.7 GO:0102008 cytosolic dipeptidase activity(GO:0102008)
0.1 0.4 GO:0047676 arachidonate-CoA ligase activity(GO:0047676)
0.1 0.6 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
0.1 0.5 GO:0009383 rRNA (cytosine-C5-)-methyltransferase activity(GO:0009383)
0.1 0.7 GO:0043532 angiostatin binding(GO:0043532)
0.1 2.1 GO:0008430 selenium binding(GO:0008430)
0.1 0.8 GO:0031752 D5 dopamine receptor binding(GO:0031752)
0.1 0.3 GO:0016503 pheromone receptor activity(GO:0016503)
0.1 0.2 GO:0050146 nucleoside phosphotransferase activity(GO:0050146)
0.1 0.3 GO:0016263 glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity(GO:0016263)
0.1 0.3 GO:0070326 very-low-density lipoprotein particle receptor binding(GO:0070326)
0.1 0.5 GO:0051022 GDP-dissociation inhibitor binding(GO:0051021) Rho GDP-dissociation inhibitor binding(GO:0051022)
0.1 0.4 GO:0008457 beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity(GO:0008457) lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity(GO:0047256)
0.1 0.4 GO:0046899 nucleoside triphosphate adenylate kinase activity(GO:0046899)
0.1 0.7 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.1 1.3 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 0.5 GO:0038051 glucocorticoid receptor activity(GO:0004883) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.1 0.2 GO:0071987 WD40-repeat domain binding(GO:0071987)
0.1 0.2 GO:0033149 FFAT motif binding(GO:0033149)
0.1 0.2 GO:0001003 polymerase III regulatory region sequence-specific DNA binding(GO:0000992) RNA polymerase III type 1 promoter sequence-specific DNA binding(GO:0001002) RNA polymerase III type 2 promoter sequence-specific DNA binding(GO:0001003)
0.0 0.1 GO:0016434 rRNA (cytosine) methyltransferase activity(GO:0016434)
0.0 0.4 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.0 0.7 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.6 GO:0003831 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity(GO:0003831)
0.0 0.1 GO:0030626 U12 snRNA binding(GO:0030626)
0.0 0.2 GO:0003883 CTP synthase activity(GO:0003883)
0.0 1.5 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.4 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 1.0 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 0.1 GO:0004530 deoxyribonuclease I activity(GO:0004530)
0.0 0.3 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.0 0.5 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.8 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.0 0.1 GO:0016435 rRNA (guanine) methyltransferase activity(GO:0016435)
0.0 0.2 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 0.2 GO:0004909 interleukin-1, Type I, activating receptor activity(GO:0004909)
0.0 0.1 GO:0050659 N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity(GO:0050659)
0.0 0.4 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.0 0.5 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.0 0.6 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.0 0.1 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0 0.4 GO:0032395 MHC class II receptor activity(GO:0032395)
0.0 0.1 GO:0019776 Atg8 ligase activity(GO:0019776)
0.0 0.4 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0 0.9 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.1 GO:0008048 calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.0 0.4 GO:0051011 microtubule minus-end binding(GO:0051011)
0.0 0.6 GO:0017127 cholesterol transporter activity(GO:0017127)
0.0 0.1 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.0 1.0 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 0.1 GO:0008241 peptidyl-dipeptidase activity(GO:0008241)
0.0 0.2 GO:0003872 6-phosphofructokinase activity(GO:0003872)
0.0 0.1 GO:0016403 dimethylargininase activity(GO:0016403)
0.0 0.7 GO:0017166 vinculin binding(GO:0017166)
0.0 0.1 GO:0004534 5'-3' exoribonuclease activity(GO:0004534)
0.0 0.4 GO:0034185 apolipoprotein binding(GO:0034185)
0.0 0.7 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.2 GO:0016015 morphogen activity(GO:0016015)
0.0 0.2 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.0 0.6 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.0 GO:0031896 V2 vasopressin receptor binding(GO:0031896)
0.0 0.1 GO:0004024 alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
0.0 0.3 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.2 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.0 0.4 GO:0070330 aromatase activity(GO:0070330)
0.0 0.1 GO:0046556 alpha-L-arabinofuranosidase activity(GO:0046556)
0.0 0.5 GO:0004697 protein kinase C activity(GO:0004697)
0.0 0.1 GO:0042296 ISG15 transferase activity(GO:0042296)
0.0 0.4 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.2 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.0 0.4 GO:0019198 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 0.6 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.4 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.3 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.8 GO:0070888 E-box binding(GO:0070888)
0.0 0.1 GO:0005412 glucose:sodium symporter activity(GO:0005412)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 PID PI3KCI AKT PATHWAY Class I PI3K signaling events mediated by Akt
0.0 1.5 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.8 PID S1P S1P4 PATHWAY S1P4 pathway
0.0 0.9 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 1.0 PID ALK1 PATHWAY ALK1 signaling events
0.0 1.8 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.0 1.3 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 0.2 PID S1P META PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.0 0.8 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 0.7 PID ERBB1 RECEPTOR PROXIMAL PATHWAY EGF receptor (ErbB1) signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.5 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 1.4 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.0 1.0 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.8 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.0 0.7 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 0.1 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.0 2.3 REACTOME AMYLOIDS Genes involved in Amyloids
0.0 0.8 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 1.0 REACTOME KINESINS Genes involved in Kinesins
0.0 1.4 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 0.2 REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY Genes involved in Adenylate cyclase inhibitory pathway
0.0 0.7 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 0.6 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.4 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 1.7 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.4 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0 0.8 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.0 0.8 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.4 REACTOME ENDOGENOUS STEROLS Genes involved in Endogenous sterols
0.0 0.5 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.5 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.8 REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.0 0.5 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.0 0.5 REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.0 0.3 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 0.5 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 0.2 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.0 0.2 REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES Genes involved in p75NTR recruits signalling complexes
0.0 0.4 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.5 REACTOME PERK REGULATED GENE EXPRESSION Genes involved in PERK regulated gene expression