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SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for NKX2-8

Z-value: 0.31

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Transcription factors associated with NKX2-8

Gene Symbol Gene ID Gene Info
NKX2-8
ENSG00000136327.6 NK2 homeobox 8

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NKX2-8hg19_v2_chr14_-_37051798_37051831-0.698.1e-04Click!

Activity profile of NKX2-8 motif

Sorted Z-values of NKX2-8 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr12_+_13349650 0.92 ENST00000256951.5
ENST00000431267.2
ENST00000542474.1
ENST00000544053.1
EMP1
epithelial membrane protein 1
chr1_-_95007193 0.77 ENST00000370207.4
ENST00000334047.7
F3
coagulation factor III (thromboplastin, tissue factor)
chr14_-_24732403 0.76 ENST00000206765.6
TGM1
transglutaminase 1
chr5_-_78808617 0.73 ENST00000282260.6
ENST00000508576.1
ENST00000535690.1
HOMER1
homer homolog 1 (Drosophila)
chr12_+_13349711 0.70 ENST00000538364.1
ENST00000396301.3
EMP1
epithelial membrane protein 1
chr11_+_35222629 0.68 ENST00000526553.1
CD44
CD44 molecule (Indian blood group)
chr9_-_22009297 0.61 ENST00000276925.6
CDKN2B
cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
chr2_-_151395525 0.58 ENST00000439275.1
RND3
Rho family GTPase 3
chr15_+_45422178 0.52 ENST00000389037.3
ENST00000558322.1
DUOX1
dual oxidase 1
chr14_-_24732368 0.52 ENST00000544573.1
TGM1
transglutaminase 1
chrX_+_115567767 0.49 ENST00000371900.4
SLC6A14
solute carrier family 6 (amino acid transporter), member 14
chr8_-_29120604 0.48 ENST00000521515.1
KIF13B
kinesin family member 13B
chr3_-_87039662 0.46 ENST00000494229.1
VGLL3
vestigial like 3 (Drosophila)
chr3_+_111717511 0.45 ENST00000478951.1
ENST00000393917.2
TAGLN3
transgelin 3
chr4_-_119274121 0.44 ENST00000296498.3
PRSS12
protease, serine, 12 (neurotrypsin, motopsin)
chr6_+_30844192 0.43 ENST00000502955.1
ENST00000505066.1
DDR1
discoidin domain receptor tyrosine kinase 1
chr16_+_8807419 0.42 ENST00000565016.1
ENST00000567812.1
ABAT
4-aminobutyrate aminotransferase
chr1_+_151512775 0.41 ENST00000368849.3
ENST00000392712.3
ENST00000353024.3
ENST00000368848.2
ENST00000538902.1
TUFT1
tuftelin 1
chr4_-_153601136 0.40 ENST00000504064.1
ENST00000304385.3
TMEM154
transmembrane protein 154
chr1_-_94147385 0.39 ENST00000260502.6
BCAR3
breast cancer anti-estrogen resistance 3
chr12_+_66218212 0.39 ENST00000393578.3
ENST00000425208.2
ENST00000536545.1
ENST00000354636.3
HMGA2
high mobility group AT-hook 2
chr10_-_101673782 0.39 ENST00000422692.1
DNMBP
dynamin binding protein
chr5_+_3596168 0.35 ENST00000302006.3
IRX1
iroquois homeobox 1
chr10_+_71078595 0.35 ENST00000359426.6
HK1
hexokinase 1
chr1_-_31902614 0.34 ENST00000596131.1
AC114494.1
HCG1787699; Uncharacterized protein
chr3_+_111717600 0.34 ENST00000273368.4
TAGLN3
transgelin 3
chr17_+_61086917 0.34 ENST00000424789.2
ENST00000389520.4
TANC2
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
chr1_+_76251912 0.34 ENST00000370826.3
RABGGTB
Rab geranylgeranyltransferase, beta subunit
chr2_-_46385 0.34 ENST00000327669.4
FAM110C
family with sequence similarity 110, member C
chr1_+_154401791 0.33 ENST00000476006.1
IL6R
interleukin 6 receptor
chr5_+_176692466 0.32 ENST00000508029.1
ENST00000503056.1
NSD1
nuclear receptor binding SET domain protein 1
chr15_-_99057551 0.32 ENST00000558256.1
FAM169B
family with sequence similarity 169, member B
chr1_-_68698222 0.31 ENST00000370976.3
ENST00000354777.2
ENST00000262348.4
ENST00000540432.1
WLS
wntless Wnt ligand secretion mediator
chr1_+_12040238 0.31 ENST00000444836.1
ENST00000235329.5
MFN2
mitofusin 2
chr7_-_127672146 0.30 ENST00000476782.1
LRRC4
leucine rich repeat containing 4
chr11_+_35211429 0.29 ENST00000525688.1
ENST00000278385.6
ENST00000533222.1
CD44
CD44 molecule (Indian blood group)
chr2_-_178129853 0.29 ENST00000397062.3
NFE2L2
nuclear factor, erythroid 2-like 2
chr7_+_135242652 0.28 ENST00000285968.6
ENST00000440390.2
NUP205
nucleoporin 205kDa
chr4_-_100484825 0.28 ENST00000273962.3
ENST00000514547.1
ENST00000455368.2
TRMT10A
tRNA methyltransferase 10 homolog A (S. cerevisiae)
chr2_-_207024233 0.27 ENST00000423725.1
ENST00000233190.6
NDUFS1
NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
chr2_+_136289030 0.26 ENST00000409478.1
ENST00000264160.4
ENST00000329971.3
ENST00000438014.1
R3HDM1
R3H domain containing 1
chr22_+_21213771 0.26 ENST00000439214.1
SNAP29
synaptosomal-associated protein, 29kDa
chr8_+_27182862 0.26 ENST00000521164.1
ENST00000346049.5
PTK2B
protein tyrosine kinase 2 beta
chr11_-_10828892 0.25 ENST00000525681.1
EIF4G2
eukaryotic translation initiation factor 4 gamma, 2
chr6_-_137113604 0.25 ENST00000359015.4
MAP3K5
mitogen-activated protein kinase kinase kinase 5
chr14_-_88282595 0.25 ENST00000554519.1
RP11-1152H15.1
RP11-1152H15.1
chr8_-_144679264 0.25 ENST00000531953.1
ENST00000526133.1
EEF1D
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
chr15_-_60683326 0.24 ENST00000559350.1
ENST00000558986.1
ENST00000560389.1
ANXA2
annexin A2
chr2_-_207023918 0.24 ENST00000455934.2
ENST00000449699.1
ENST00000454195.1
NDUFS1
NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
chr3_+_63953415 0.24 ENST00000484332.1
ATXN7
ataxin 7
chr9_-_128412696 0.24 ENST00000420643.1
MAPKAP1
mitogen-activated protein kinase associated protein 1
chr17_-_8055747 0.24 ENST00000317276.4
ENST00000581703.1
PER1
period circadian clock 1
chr12_+_66218903 0.23 ENST00000393577.3
HMGA2
high mobility group AT-hook 2
chr18_-_72920372 0.23 ENST00000581620.1
ENST00000582437.1
ZADH2
zinc binding alcohol dehydrogenase domain containing 2
chr20_+_58296265 0.23 ENST00000395636.2
ENST00000361300.4
PHACTR3
phosphatase and actin regulator 3
chr1_-_115292591 0.22 ENST00000438362.2
CSDE1
cold shock domain containing E1, RNA-binding
chr8_+_104310661 0.22 ENST00000522566.1
FZD6
frizzled family receptor 6
chr3_+_187930429 0.22 ENST00000420410.1
LPP
LIM domain containing preferred translocation partner in lipoma
chr9_+_109685630 0.22 ENST00000451160.2
RP11-508N12.4
Uncharacterized protein
chr11_-_128457446 0.22 ENST00000392668.4
ETS1
v-ets avian erythroblastosis virus E26 oncogene homolog 1
chr12_+_25205568 0.22 ENST00000548766.1
ENST00000556887.1
LRMP
lymphoid-restricted membrane protein
chr1_+_152957707 0.22 ENST00000368762.1
SPRR1A
small proline-rich protein 1A
chr13_+_28712614 0.22 ENST00000380958.3
PAN3
PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)
chr2_-_207024134 0.21 ENST00000457011.1
ENST00000440274.1
ENST00000432169.1
NDUFS1
NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
chr6_-_32145861 0.21 ENST00000336984.6
AGPAT1
1-acylglycerol-3-phosphate O-acyltransferase 1
chr4_-_7873713 0.21 ENST00000382543.3
AFAP1
actin filament associated protein 1
chr21_-_35899113 0.21 ENST00000492600.1
ENST00000481448.1
ENST00000381132.2
RCAN1
regulator of calcineurin 1
chr1_+_16083098 0.20 ENST00000496928.2
ENST00000508310.1
FBLIM1
filamin binding LIM protein 1
chrX_+_123094672 0.20 ENST00000354548.5
ENST00000458700.1
STAG2
stromal antigen 2
chr1_+_55464600 0.19 ENST00000371265.4
BSND
Bartter syndrome, infantile, with sensorineural deafness (Barttin)
chr3_-_16524357 0.19 ENST00000432519.1
RFTN1
raftlin, lipid raft linker 1
chr18_-_44497308 0.19 ENST00000585916.1
ENST00000324794.7
ENST00000545673.1
PIAS2
protein inhibitor of activated STAT, 2
chr4_+_144303093 0.19 ENST00000505913.1
GAB1
GRB2-associated binding protein 1
chr5_+_43602750 0.19 ENST00000505678.2
ENST00000512422.1
ENST00000264663.5
NNT
nicotinamide nucleotide transhydrogenase
chr6_+_143772060 0.19 ENST00000367591.4
PEX3
peroxisomal biogenesis factor 3
chr14_-_36990354 0.19 ENST00000518149.1
NKX2-1
NK2 homeobox 1
chr10_+_123951957 0.19 ENST00000514539.1
TACC2
transforming, acidic coiled-coil containing protein 2
chr6_-_131299929 0.18 ENST00000531356.1
EPB41L2
erythrocyte membrane protein band 4.1-like 2
chr16_+_23194033 0.18 ENST00000300061.2
SCNN1G
sodium channel, non-voltage-gated 1, gamma subunit
chr12_+_25205666 0.18 ENST00000547044.1
LRMP
lymphoid-restricted membrane protein
chr12_+_25205446 0.18 ENST00000557489.1
ENST00000354454.3
ENST00000536173.1
LRMP
lymphoid-restricted membrane protein
chr15_+_74911430 0.18 ENST00000562670.1
ENST00000564096.1
CLK3
CDC-like kinase 3
chr6_+_158957431 0.18 ENST00000367090.3
TMEM181
transmembrane protein 181
chr11_-_117170403 0.18 ENST00000504995.1
BACE1
beta-site APP-cleaving enzyme 1
chr4_-_100485183 0.18 ENST00000394876.2
TRMT10A
tRNA methyltransferase 10 homolog A (S. cerevisiae)
chr9_+_131873842 0.18 ENST00000417728.1
PPP2R4
protein phosphatase 2A activator, regulatory subunit 4
chr17_-_62503015 0.18 ENST00000581806.1
DDX5
DEAD (Asp-Glu-Ala-Asp) box helicase 5
chrX_-_64196376 0.18 ENST00000447788.2
ZC4H2
zinc finger, C4H2 domain containing
chr13_-_23949671 0.18 ENST00000402364.1
SACS
spastic ataxia of Charlevoix-Saguenay (sacsin)
chr20_-_57089934 0.18 ENST00000439429.1
ENST00000371149.3
APCDD1L
adenomatosis polyposis coli down-regulated 1-like
chrX_-_64196351 0.17 ENST00000374839.3
ZC4H2
zinc finger, C4H2 domain containing
chr14_+_76618242 0.17 ENST00000557542.1
ENST00000557263.1
ENST00000557207.1
ENST00000312858.5
ENST00000261530.7
GPATCH2L
G patch domain containing 2-like
chr3_-_187455680 0.17 ENST00000438077.1
BCL6
B-cell CLL/lymphoma 6
chr14_+_58894404 0.17 ENST00000554463.1
ENST00000555833.1
KIAA0586
KIAA0586
chr12_+_121837905 0.17 ENST00000392465.3
ENST00000554606.1
ENST00000392464.2
ENST00000555076.1
RNF34
ring finger protein 34, E3 ubiquitin protein ligase
chrX_-_32173579 0.17 ENST00000359836.1
ENST00000343523.2
ENST00000378707.3
ENST00000541735.1
ENST00000474231.1
DMD
dystrophin
chr11_+_27062272 0.17 ENST00000529202.1
ENST00000533566.1
BBOX1
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr8_+_107593198 0.17 ENST00000517686.1
OXR1
oxidation resistance 1
chr17_-_46178527 0.17 ENST00000393408.3
CBX1
chromobox homolog 1
chr12_-_46663734 0.17 ENST00000550173.1
SLC38A1
solute carrier family 38, member 1
chr22_+_20877924 0.17 ENST00000445189.1
MED15
mediator complex subunit 15
chr7_+_18330035 0.16 ENST00000413509.2
HDAC9
histone deacetylase 9
chr13_-_46756351 0.16 ENST00000323076.2
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr2_-_110371720 0.16 ENST00000356688.4
SEPT10
septin 10
chr5_+_14664762 0.16 ENST00000284274.4
FAM105B
family with sequence similarity 105, member B
chr14_+_37667230 0.15 ENST00000556451.1
ENST00000556753.1
ENST00000396294.2
MIPOL1
mirror-image polydactyly 1
chr7_-_137686791 0.15 ENST00000452463.1
ENST00000330387.6
ENST00000456390.1
CREB3L2
cAMP responsive element binding protein 3-like 2
chr5_+_34929677 0.15 ENST00000342382.4
ENST00000382021.2
ENST00000303525.7
DNAJC21
DnaJ (Hsp40) homolog, subfamily C, member 21
chr22_-_30925150 0.15 ENST00000437871.1
SEC14L6
SEC14-like 6 (S. cerevisiae)
chr3_-_52739670 0.15 ENST00000497953.1
GLT8D1
glycosyltransferase 8 domain containing 1
chr2_+_119699864 0.15 ENST00000541757.1
ENST00000412481.1
MARCO
macrophage receptor with collagenous structure
chr20_+_55967129 0.15 ENST00000371219.2
RBM38
RNA binding motif protein 38
chr14_-_107219365 0.14 ENST00000424969.2
IGHV3-74
immunoglobulin heavy variable 3-74
chr3_-_125094093 0.14 ENST00000484491.1
ENST00000492394.1
ENST00000471196.1
ENST00000468369.1
ENST00000544464.1
ENST00000485866.1
ENST00000360647.4
ZNF148
zinc finger protein 148
chr10_+_24755416 0.14 ENST00000396446.1
ENST00000396445.1
ENST00000376451.2
KIAA1217
KIAA1217
chr17_+_34901353 0.14 ENST00000593016.1
GGNBP2
gametogenetin binding protein 2
chr12_+_25205155 0.14 ENST00000550945.1
LRMP
lymphoid-restricted membrane protein
chr7_+_30185496 0.14 ENST00000455738.1
C7orf41
maturin, neural progenitor differentiation regulator homolog (Xenopus)
chrX_-_64196307 0.14 ENST00000545618.1
ZC4H2
zinc finger, C4H2 domain containing
chrX_+_118533269 0.13 ENST00000336249.7
SLC25A43
solute carrier family 25, member 43
chr11_-_77348796 0.13 ENST00000263309.3
ENST00000525064.1
CLNS1A
chloride channel, nucleotide-sensitive, 1A
chr1_+_109289279 0.13 ENST00000370008.3
STXBP3
syntaxin binding protein 3
chr22_+_29834572 0.13 ENST00000354373.2
RFPL1
ret finger protein-like 1
chr12_-_95397442 0.13 ENST00000547157.1
ENST00000547986.1
ENST00000327772.2
NDUFA12
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12
chr1_+_10057274 0.13 ENST00000294435.7
RBP7
retinol binding protein 7, cellular
chr20_-_48747662 0.13 ENST00000371656.2
TMEM189
transmembrane protein 189
chr8_-_141810634 0.13 ENST00000521986.1
ENST00000523539.1
ENST00000538769.1
PTK2
protein tyrosine kinase 2
chr4_+_141264597 0.13 ENST00000338517.4
ENST00000394203.3
ENST00000506322.1
SCOC
short coiled-coil protein
chr1_+_224301787 0.12 ENST00000366862.5
ENST00000424254.2
FBXO28
F-box protein 28
chr8_-_145018905 0.12 ENST00000398774.2
PLEC
plectin
chr3_+_187930491 0.12 ENST00000443217.1
LPP
LIM domain containing preferred translocation partner in lipoma
chr14_+_58765103 0.12 ENST00000355431.3
ENST00000348476.3
ENST00000395168.3
ARID4A
AT rich interactive domain 4A (RBP1-like)
chr17_+_46185111 0.11 ENST00000582104.1
ENST00000584335.1
SNX11
sorting nexin 11
chr7_-_86974767 0.11 ENST00000610086.1
TP53TG1
TP53 target 1 (non-protein coding)
chr1_+_16083123 0.11 ENST00000510393.1
ENST00000430076.1
FBLIM1
filamin binding LIM protein 1
chr5_+_68665608 0.11 ENST00000509734.1
ENST00000354868.5
ENST00000521422.1
ENST00000354312.3
ENST00000345306.6
RAD17
RAD17 homolog (S. pombe)
chr2_+_119699742 0.11 ENST00000327097.4
MARCO
macrophage receptor with collagenous structure
chr12_+_60058458 0.10 ENST00000548610.1
SLC16A7
solute carrier family 16 (monocarboxylate transporter), member 7
chr7_+_30634297 0.10 ENST00000389266.3
GARS
glycyl-tRNA synthetase
chr7_+_112063192 0.10 ENST00000005558.4
IFRD1
interferon-related developmental regulator 1
chrX_+_123094369 0.10 ENST00000455404.1
ENST00000218089.9
STAG2
stromal antigen 2
chr22_+_38609538 0.10 ENST00000407965.1
MAFF
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
chr7_-_127671674 0.10 ENST00000478726.1
LRRC4
leucine rich repeat containing 4
chr17_+_71228793 0.09 ENST00000426147.2
C17orf80
chromosome 17 open reading frame 80
chr4_-_100485143 0.09 ENST00000394877.3
TRMT10A
tRNA methyltransferase 10 homolog A (S. cerevisiae)
chr11_-_104827425 0.09 ENST00000393150.3
CASP4
caspase 4, apoptosis-related cysteine peptidase
chr2_-_106054952 0.09 ENST00000336660.5
ENST00000393352.3
ENST00000607522.1
FHL2
four and a half LIM domains 2
chr1_+_173793777 0.09 ENST00000239457.5
DARS2
aspartyl-tRNA synthetase 2, mitochondrial
chr3_+_39093481 0.09 ENST00000302313.5
ENST00000544962.1
ENST00000396258.3
ENST00000418020.1
WDR48
WD repeat domain 48
chr3_+_4535025 0.09 ENST00000302640.8
ENST00000354582.6
ENST00000423119.2
ENST00000357086.4
ENST00000456211.2
ITPR1
inositol 1,4,5-trisphosphate receptor, type 1
chr2_+_62132781 0.08 ENST00000311832.5
COMMD1
copper metabolism (Murr1) domain containing 1
chr16_-_67493110 0.08 ENST00000602876.1
ATP6V0D1
ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1
chr3_+_126423045 0.08 ENST00000290913.3
ENST00000508789.1
CHCHD6
coiled-coil-helix-coiled-coil-helix domain containing 6
chr2_-_197675000 0.08 ENST00000342506.2
C2orf66
chromosome 2 open reading frame 66
chr11_-_19223523 0.08 ENST00000265968.3
CSRP3
cysteine and glycine-rich protein 3 (cardiac LIM protein)
chr3_+_177545563 0.08 ENST00000434309.1
RP11-91K9.1
RP11-91K9.1
chr14_-_78083112 0.08 ENST00000216484.2
SPTLC2
serine palmitoyltransferase, long chain base subunit 2
chr14_+_58765305 0.08 ENST00000445108.1
ARID4A
AT rich interactive domain 4A (RBP1-like)
chr1_-_104238912 0.08 ENST00000330330.5
AMY1B
amylase, alpha 1B (salivary)
chr19_+_52074502 0.08 ENST00000545217.1
ENST00000262259.2
ENST00000596504.1
ZNF175
zinc finger protein 175
chr17_-_62502639 0.08 ENST00000225792.5
ENST00000581697.1
ENST00000584279.1
ENST00000577922.1
DDX5
DEAD (Asp-Glu-Ala-Asp) box helicase 5
chr9_-_99637820 0.08 ENST00000289032.8
ENST00000535338.1
ZNF782
zinc finger protein 782
chr22_+_39101728 0.08 ENST00000216044.5
ENST00000484657.1
GTPBP1
GTP binding protein 1
chr11_-_77348821 0.08 ENST00000528364.1
ENST00000532069.1
ENST00000525428.1
CLNS1A
chloride channel, nucleotide-sensitive, 1A
chr3_-_47950745 0.07 ENST00000429422.1
MAP4
microtubule-associated protein 4
chr11_+_59705928 0.07 ENST00000398992.1
OOSP1
oocyte secreted protein 1
chr14_-_106068065 0.07 ENST00000390541.2
IGHE
immunoglobulin heavy constant epsilon
chr19_-_44259053 0.07 ENST00000601170.1
SMG9
SMG9 nonsense mediated mRNA decay factor
chr19_-_11347173 0.07 ENST00000587656.1
DOCK6
dedicator of cytokinesis 6
chrM_+_8366 0.07 ENST00000361851.1
MT-ATP8
mitochondrially encoded ATP synthase 8
chr2_-_136288740 0.06 ENST00000264159.6
ENST00000536680.1
ZRANB3
zinc finger, RAN-binding domain containing 3
chr3_+_10183447 0.06 ENST00000345392.2
VHL
von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
chrX_+_72064690 0.06 ENST00000438696.1
DMRTC1B
DMRT-like family C1B
chr16_-_3350614 0.06 ENST00000268674.2
TIGD7
tigger transposable element derived 7
chrM_+_8527 0.06 ENST00000361899.2
MT-ATP6
mitochondrially encoded ATP synthase 6
chr12_+_66218598 0.06 ENST00000541363.1
HMGA2
high mobility group AT-hook 2
chr12_+_25205628 0.06 ENST00000554942.1
LRMP
lymphoid-restricted membrane protein
chr20_+_42143136 0.06 ENST00000373134.1
L3MBTL1
l(3)mbt-like 1 (Drosophila)
chr19_-_17622269 0.06 ENST00000595116.1
CTD-3131K8.2
CTD-3131K8.2
chr11_+_925824 0.06 ENST00000525796.1
ENST00000534328.1
ENST00000448903.2
ENST00000332231.5
AP2A2
adaptor-related protein complex 2, alpha 2 subunit
chr6_-_18249971 0.05 ENST00000507591.1
DEK
DEK oncogene
chr11_-_10715117 0.05 ENST00000527509.2
MRVI1
murine retrovirus integration site 1 homolog
chr18_-_24722995 0.05 ENST00000581714.1
CHST9
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9
chr14_-_106518922 0.05 ENST00000390598.2
IGHV3-7
immunoglobulin heavy variable 3-7
chr14_-_107199464 0.05 ENST00000433072.2
IGHV3-72
immunoglobulin heavy variable 3-72
chr15_-_70387120 0.05 ENST00000539550.1
TLE3
transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)
chr17_+_39994032 0.05 ENST00000293303.4
ENST00000438813.1
KLHL10
kelch-like family member 10
chr3_+_101498026 0.05 ENST00000495842.1
NXPE3
neurexophilin and PC-esterase domain family, member 3
chr2_+_207024306 0.05 ENST00000236957.5
ENST00000392221.1
ENST00000392222.2
ENST00000445505.1
EEF1B2
eukaryotic translation elongation factor 1 beta 2
chr3_-_53164423 0.05 ENST00000467048.1
ENST00000394738.3
ENST00000296292.3
RFT1
RFT1 homolog (S. cerevisiae)
chr19_-_3600549 0.05 ENST00000589966.1
TBXA2R
thromboxane A2 receptor
chr17_+_62503073 0.05 ENST00000580188.1
ENST00000581056.1
CEP95
centrosomal protein 95kDa
chr14_-_106791536 0.05 ENST00000390613.2
IGHV3-30
immunoglobulin heavy variable 3-30
chr22_+_32753854 0.04 ENST00000249007.4
RFPL3
ret finger protein-like 3
chr7_+_73507409 0.04 ENST00000538333.3
LIMK1
LIM domain kinase 1
chr2_-_55277436 0.04 ENST00000354474.6
RTN4
reticulon 4
chr14_+_37667193 0.04 ENST00000539062.2
MIPOL1
mirror-image polydactyly 1
chr22_+_38453207 0.04 ENST00000404072.3
ENST00000424694.1
PICK1
protein interacting with PRKCA 1
chr10_-_135171178 0.04 ENST00000368551.1
FUOM
fucose mutarotase
chr16_+_4606347 0.04 ENST00000444310.4
C16orf96
chromosome 16 open reading frame 96

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX2-8

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0002541 activation of plasma proteins involved in acute inflammatory response(GO:0002541)
0.2 1.3 GO:0043163 cell envelope organization(GO:0043163) external encapsulating structure organization(GO:0045229)
0.2 0.7 GO:0007206 phospholipase C-activating G-protein coupled glutamate receptor signaling pathway(GO:0007206)
0.2 0.7 GO:0003131 mesodermal-endodermal cell signaling(GO:0003131) programmed DNA elimination(GO:0031049) chromosome breakage(GO:0031052) histone H2A-S139 phosphorylation(GO:0035978) positive regulation of cellular response to X-ray(GO:2000685)
0.1 1.0 GO:1900625 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.1 0.4 GO:0072086 specification of loop of Henle identity(GO:0072086) pattern specification involved in metanephros development(GO:0072268)
0.1 0.5 GO:0042335 cuticle development(GO:0042335)
0.1 0.4 GO:0014053 negative regulation of gamma-aminobutyric acid secretion(GO:0014053) aspartate secretion(GO:0061528) regulation of aspartate secretion(GO:1904448) positive regulation of aspartate secretion(GO:1904450)
0.1 0.3 GO:0002384 hepatic immune response(GO:0002384)
0.1 0.3 GO:0061357 positive regulation of Wnt protein secretion(GO:0061357)
0.1 0.2 GO:0052361 multi-organism catabolic process(GO:0044035) development of symbiont involved in interaction with host(GO:0044115) modulation of development of symbiont involved in interaction with host(GO:0044145) negative regulation of development of symbiont involved in interaction with host(GO:0044147) metabolism of substance in other organism involved in symbiotic interaction(GO:0052214) catabolism of substance in other organism involved in symbiotic interaction(GO:0052227) metabolism of macromolecule in other organism involved in symbiotic interaction(GO:0052229) catabolism by host of symbiont macromolecule(GO:0052360) catabolism by organism of macromolecule in other organism involved in symbiotic interaction(GO:0052361) catabolism by host of symbiont protein(GO:0052362) catabolism by organism of protein in other organism involved in symbiotic interaction(GO:0052363) catabolism by host of substance in symbiont(GO:0052364) metabolism by host of symbiont macromolecule(GO:0052416) metabolism by host of symbiont protein(GO:0052417) metabolism by organism of protein in other organism involved in symbiotic interaction(GO:0052418) metabolism by host of substance in symbiont(GO:0052419)
0.1 0.2 GO:0009405 pathogenesis(GO:0009405)
0.1 0.2 GO:2000374 regulation of oxygen metabolic process(GO:2000374)
0.1 0.2 GO:0035880 embryonic nail plate morphogenesis(GO:0035880)
0.1 1.6 GO:0032060 bleb assembly(GO:0032060)
0.1 0.3 GO:0016240 autophagosome docking(GO:0016240)
0.0 0.2 GO:0032764 negative regulation of mast cell cytokine production(GO:0032764) negative regulation of isotype switching to IgE isotypes(GO:0048294)
0.0 0.3 GO:0046223 mycotoxin catabolic process(GO:0043387) aflatoxin catabolic process(GO:0046223) organic heteropentacyclic compound catabolic process(GO:1901377) regulation of glutathione biosynthetic process(GO:1903786) positive regulation of glutathione biosynthetic process(GO:1903788)
0.0 0.5 GO:0034770 histone H4-K20 methylation(GO:0034770)
0.0 0.3 GO:2000537 regulation of cGMP-mediated signaling(GO:0010752) regulation of B cell chemotaxis(GO:2000537) positive regulation of B cell chemotaxis(GO:2000538)
0.0 0.1 GO:0033140 negative regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033140)
0.0 0.3 GO:0018344 protein geranylgeranylation(GO:0018344)
0.0 0.2 GO:0030950 establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.0 0.4 GO:0072656 maintenance of protein location in mitochondrion(GO:0072656)
0.0 0.2 GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966)
0.0 0.2 GO:2000323 negative regulation of glucocorticoid receptor signaling pathway(GO:2000323)
0.0 0.2 GO:0006740 NADPH regeneration(GO:0006740)
0.0 0.1 GO:0006667 sphinganine metabolic process(GO:0006667)
0.0 0.2 GO:0030578 PML body organization(GO:0030578)
0.0 0.1 GO:0015960 diadenosine polyphosphate biosynthetic process(GO:0015960) diadenosine tetraphosphate metabolic process(GO:0015965) diadenosine tetraphosphate biosynthetic process(GO:0015966)
0.0 0.2 GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
0.0 0.2 GO:0016557 peroxisome membrane biogenesis(GO:0016557)
0.0 0.4 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.0 0.1 GO:0006421 asparaginyl-tRNA aminoacylation(GO:0006421)
0.0 0.1 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
0.0 0.3 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
0.0 0.3 GO:0072383 plus-end-directed vesicle transport along microtubule(GO:0072383)
0.0 0.1 GO:0048706 embryonic skeletal system development(GO:0048706)
0.0 0.2 GO:0021759 globus pallidus development(GO:0021759)
0.0 0.1 GO:0038193 thromboxane A2 signaling pathway(GO:0038193)
0.0 0.1 GO:0035995 detection of muscle stretch(GO:0035995)
0.0 0.2 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.0 0.2 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.0 0.1 GO:0036292 DNA rewinding(GO:0036292)
0.0 0.3 GO:0033623 regulation of integrin activation(GO:0033623)
0.0 0.3 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
0.0 0.3 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.0 0.3 GO:0097119 postsynaptic density protein 95 clustering(GO:0097119)
0.0 0.2 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.0 0.3 GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.0 0.1 GO:1901475 pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475)
0.0 0.1 GO:0061428 negative regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061428)
0.0 0.1 GO:0090598 male genitalia morphogenesis(GO:0048808) male anatomical structure morphogenesis(GO:0090598)
0.0 0.1 GO:0048625 myoblast fate commitment(GO:0048625)
0.0 0.5 GO:1903846 positive regulation of transforming growth factor beta receptor signaling pathway(GO:0030511) positive regulation of cellular response to transforming growth factor beta stimulus(GO:1903846)
0.0 0.4 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.0 0.5 GO:0030488 tRNA methylation(GO:0030488)
0.0 0.2 GO:0010663 positive regulation of striated muscle cell apoptotic process(GO:0010663) positive regulation of cardiac muscle cell apoptotic process(GO:0010666)
0.0 0.1 GO:0051012 microtubule sliding(GO:0051012)
0.0 0.2 GO:0051292 nuclear pore complex assembly(GO:0051292)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.1 0.7 GO:0045272 plasma membrane respiratory chain complex I(GO:0045272)
0.1 0.4 GO:0032144 4-aminobutyrate transaminase complex(GO:0032144)
0.1 0.3 GO:0044611 nuclear pore inner ring(GO:0044611)
0.1 0.3 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.1 0.3 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.1 0.7 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.1 0.2 GO:0031251 PAN complex(GO:0031251)
0.0 0.2 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)
0.0 0.2 GO:1990667 PCSK9-AnxA2 complex(GO:1990667)
0.0 0.2 GO:0070931 Golgi-associated vesicle lumen(GO:0070931)
0.0 0.3 GO:0020018 ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018)
0.0 0.2 GO:0034715 pICln-Sm protein complex(GO:0034715)
0.0 0.4 GO:0043083 synaptic cleft(GO:0043083)
0.0 0.3 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.8 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
0.0 0.2 GO:0070852 cell body fiber(GO:0070852)
0.0 1.5 GO:0001533 cornified envelope(GO:0001533)
0.0 0.2 GO:0016013 syntrophin complex(GO:0016013)
0.0 0.8 GO:0043034 costamere(GO:0043034)
0.0 0.2 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.0 0.2 GO:0001940 male pronucleus(GO:0001940)
0.0 0.3 GO:0033270 paranode region of axon(GO:0033270)
0.0 0.1 GO:0061617 MICOS complex(GO:0061617)
0.0 0.3 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 0.4 GO:0043209 myelin sheath(GO:0043209)
0.0 0.2 GO:0008091 spectrin(GO:0008091)
0.0 0.1 GO:0097169 AIM2 inflammasome complex(GO:0097169)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0035501 MH1 domain binding(GO:0035501)
0.1 0.3 GO:0070119 ciliary neurotrophic factor binding(GO:0070119)
0.1 0.6 GO:0009019 tRNA (guanine-N1-)-methyltransferase activity(GO:0009019)
0.1 1.3 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.1 0.4 GO:0003867 4-aminobutyrate transaminase activity(GO:0003867) succinate-semialdehyde dehydrogenase binding(GO:0032145) (S)-3-amino-2-methylpropionate transaminase activity(GO:0047298)
0.1 0.4 GO:0030021 extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345)
0.1 0.2 GO:0016652 NAD(P)+ transhydrogenase activity(GO:0008746) oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor(GO:0016652)
0.1 0.3 GO:0042799 histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.1 0.3 GO:0004663 Rab geranylgeranyltransferase activity(GO:0004663)
0.1 0.3 GO:0035500 MH2 domain binding(GO:0035500)
0.0 0.2 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.0 0.3 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.0 0.4 GO:0004396 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.0 0.2 GO:0008798 beta-aspartyl-peptidase activity(GO:0008798)
0.0 0.5 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.0 0.2 GO:0047522 13-prostaglandin reductase activity(GO:0036132) 15-oxoprostaglandin 13-oxidase activity(GO:0047522)
0.0 0.7 GO:0035256 G-protein coupled glutamate receptor binding(GO:0035256)
0.0 0.2 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.0 0.4 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.0 0.6 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 0.1 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.0 1.0 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.2 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
0.0 0.7 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 0.2 GO:0061665 SUMO ligase activity(GO:0061665)
0.0 0.1 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0 0.1 GO:0032093 SAM domain binding(GO:0032093)
0.0 0.2 GO:0030280 structural constituent of epidermis(GO:0030280)
0.0 0.3 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.0 0.1 GO:0004961 thromboxane receptor activity(GO:0004960) thromboxane A2 receptor activity(GO:0004961)
0.0 0.4 GO:0044213 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213)
0.0 0.5 GO:0005328 neurotransmitter:sodium symporter activity(GO:0005328)
0.0 0.1 GO:0004815 aspartate-tRNA ligase activity(GO:0004815)
0.0 0.2 GO:1990226 histone methyltransferase binding(GO:1990226)
0.0 0.2 GO:0042731 PH domain binding(GO:0042731)
0.0 0.2 GO:0005283 sodium:amino acid symporter activity(GO:0005283)
0.0 0.3 GO:0031005 filamin binding(GO:0031005)
0.0 0.1 GO:0033170 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0 0.1 GO:0016454 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.1 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.5 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.8 REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE Genes involved in Formation of Fibrin Clot (Clotting Cascade)
0.0 0.3 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.0 0.4 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation