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SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for NKX3-2

Z-value: 0.64

Motif logo

Transcription factors associated with NKX3-2

Gene Symbol Gene ID Gene Info
ENSG00000109705.7 NK3 homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NKX3-2hg19_v2_chr4_-_13546632_13546674-0.243.1e-01Click!

Activity profile of NKX3-2 motif

Sorted Z-values of NKX3-2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr3_+_193853927 0.79 ENST00000232424.3
hes family bHLH transcription factor 1
chr1_+_205473720 0.73 ENST00000429964.2
ENST00000506784.1
ENST00000360066.2
cyclin-dependent kinase 18
chr12_+_4382917 0.68 ENST00000261254.3
cyclin D2
chr11_-_119993979 0.63 ENST00000524816.3
ENST00000525327.1
tripartite motif containing 29
chr2_-_25451065 0.62 ENST00000606328.1
RP11-458N5.1
chr10_-_98031265 0.62 ENST00000224337.5
ENST00000371176.2
B-cell linker
chr19_-_6720686 0.62 ENST00000245907.6
complement component 3
chr19_-_6670128 0.60 ENST00000245912.3
tumor necrosis factor (ligand) superfamily, member 14
chr10_-_98031310 0.60 ENST00000427367.2
ENST00000413476.2
B-cell linker
chr12_-_10022735 0.59 ENST00000228438.2
C-type lectin domain family 2, member B
chr15_-_31521567 0.55 ENST00000560812.1
ENST00000559853.1
ENST00000558109.1
RP11-16E12.2
chr10_-_95360983 0.53 ENST00000371464.3
retinol binding protein 4, plasma
chr19_+_18544045 0.53 ENST00000599699.2
single stranded DNA binding protein 4
chr10_-_7708918 0.52 ENST00000256861.6
ENST00000397146.2
ENST00000446830.2
ENST00000397145.2
inter-alpha-trypsin inhibitor heavy chain family, member 5
chr2_+_17721920 0.51 ENST00000295156.4
visinin-like 1
chr1_+_26606608 0.51 ENST00000319041.6
SH3 domain binding glutamic acid-rich protein like 3
chr17_-_1619568 0.49 ENST00000571595.1
MIR22 host gene (non-protein coding)
chr19_+_7694623 0.48 ENST00000594797.1
ENST00000456958.3
ENST00000601406.1
PET100 homolog (S. cerevisiae)
chr11_-_59633951 0.45 ENST00000257264.3
transcobalamin I (vitamin B12 binding protein, R binder family)
chr6_-_32784687 0.44 ENST00000447394.1
ENST00000438763.2
major histocompatibility complex, class II, DO beta
chr19_-_36297348 0.44 ENST00000589835.1
proline dehydrogenase (oxidase) 2
chr1_+_205473784 0.44 ENST00000478560.1
ENST00000443813.2
cyclin-dependent kinase 18
chr11_+_35222629 0.43 ENST00000526553.1
CD44 molecule (Indian blood group)
chr20_-_39995467 0.42 ENST00000332312.3
elastin microfibril interfacer 3
chr8_-_49833978 0.42 ENST00000020945.1
snail family zinc finger 2
chr2_+_208104497 0.41 ENST00000430494.1
AC007879.7
chr1_+_152974218 0.41 ENST00000331860.3
ENST00000443178.1
ENST00000295367.4
small proline-rich protein 3
chr19_+_48867652 0.40 ENST00000344846.2
synaptogyrin 4
chr15_+_41136734 0.40 ENST00000568580.1
serine peptidase inhibitor, Kunitz type 1
chr3_+_50192537 0.40 ENST00000002829.3
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
chr3_+_50192499 0.40 ENST00000413852.1
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
chrX_+_105937068 0.39 ENST00000324342.3
ring finger protein 128, E3 ubiquitin protein ligase
chr19_+_54609230 0.39 ENST00000420296.1
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa
chr11_+_64879317 0.39 ENST00000526809.1
ENST00000279263.7
ENST00000524986.1
ENST00000534371.1
ENST00000540748.1
ENST00000525385.1
ENST00000345348.5
ENST00000531321.1
ENST00000529414.1
ENST00000526085.1
ENST00000530750.1
transmembrane 7 superfamily member 2
chr1_+_86889769 0.39 ENST00000370565.4
chloride channel accessory 2
chr7_-_45957011 0.39 ENST00000417621.1
insulin-like growth factor binding protein 3
chr12_-_50616122 0.39 ENST00000552823.1
ENST00000552909.1
LIM domain and actin binding 1
chr8_-_49834299 0.38 ENST00000396822.1
snail family zinc finger 2
chr2_-_25016251 0.38 ENST00000328379.5
peptidyl-tRNA hydrolase domain containing 1
chrX_+_105936982 0.38 ENST00000418562.1
ring finger protein 128, E3 ubiquitin protein ligase
chr9_-_22009297 0.36 ENST00000276925.6
cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
chr5_-_149792295 0.36 ENST00000518797.1
ENST00000524315.1
ENST00000009530.7
ENST00000377795.3
CD74 molecule, major histocompatibility complex, class II invariant chain
chr22_+_38453207 0.36 ENST00000404072.3
ENST00000424694.1
protein interacting with PRKCA 1
chr12_+_56473939 0.34 ENST00000450146.2
v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3
chr22_-_31328881 0.34 ENST00000445980.1
MORC family CW-type zinc finger 2
chr19_-_5680202 0.34 ENST00000590389.1
chromosome 19 open reading frame 70
chr1_-_204183071 0.34 ENST00000308302.3
golgi transport 1A
chr14_+_78227105 0.33 ENST00000439131.2
ENST00000355883.3
ENST00000557011.1
ENST00000556047.1
chromosome 14 open reading frame 178
chr8_-_29592736 0.33 ENST00000518623.1
long intergenic non-protein coding RNA 589
chr3_-_107777208 0.33 ENST00000398258.3
CD47 molecule
chr19_-_10444188 0.33 ENST00000293677.6
ribonucleoprotein, PTB-binding 1
chr7_-_45956856 0.33 ENST00000428530.1
insulin-like growth factor binding protein 3
chr10_-_131762105 0.32 ENST00000368648.3
ENST00000355311.5
early B-cell factor 3
chr1_+_149822620 0.32 ENST00000369159.2
histone cluster 2, H2aa4
chr5_-_77072085 0.32 ENST00000518338.2
ENST00000520039.1
ENST00000306388.6
ENST00000520361.1
tubulin folding cofactor A
chr9_+_35906176 0.32 ENST00000354323.2
histidine rich carboxyl terminus 1
chr7_-_102213030 0.31 ENST00000511313.1
ENST00000513438.1
ENST00000513506.1
polymerase (RNA) II (DNA directed) polypeptide J3
chr10_+_7745232 0.31 ENST00000358415.4
inter-alpha-trypsin inhibitor heavy chain 2
chr7_+_90339169 0.31 ENST00000436577.2
cyclin-dependent kinase 14
chr11_+_128563652 0.31 ENST00000527786.2
Fli-1 proto-oncogene, ETS transcription factor
chr14_+_21566980 0.31 ENST00000418511.2
ENST00000554329.2
transmembrane protein 253
chrX_+_51928002 0.31 ENST00000375626.3
melanoma antigen family D, 4
chr8_+_35649365 0.31 ENST00000437887.1
Uncharacterized protein
chr9_+_34458771 0.31 ENST00000437363.1
ENST00000242317.4
dynein, axonemal, intermediate chain 1
chr20_-_2821271 0.30 ENST00000448755.1
ENST00000360652.2
PC-esterase domain containing 1A
chr11_+_66045634 0.30 ENST00000528852.1
ENST00000311445.6
cornichon family AMPA receptor auxiliary protein 2
chr7_-_8276508 0.30 ENST00000401396.1
ENST00000317367.5
islet cell autoantigen 1, 69kDa
chr3_-_69249863 0.30 ENST00000478263.1
ENST00000462512.1
FERM domain containing 4B
chrX_+_48660287 0.29 ENST00000444343.2
ENST00000376610.2
ENST00000334136.5
ENST00000376619.2
histone deacetylase 6
chr22_-_21356375 0.29 ENST00000215742.4
ENST00000399133.2
THAP domain containing 7
chr14_-_62162541 0.29 ENST00000557544.1
HIF1A antisense RNA 1
chr21_-_33985127 0.29 ENST00000290155.3
chromosome 21 open reading frame 59
chr20_+_1115821 0.29 ENST00000435720.1
proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
chr1_-_149814478 0.29 ENST00000369161.3
histone cluster 2, H2aa3
chr1_-_155145721 0.28 ENST00000295682.4
keratinocyte associated protein 2
chr7_+_90338712 0.28 ENST00000265741.3
ENST00000406263.1
cyclin-dependent kinase 14
chr12_-_113658892 0.28 ENST00000299732.2
ENST00000416617.2
IQ motif containing D
chr2_-_27294500 0.28 ENST00000447619.1
ENST00000429985.1
ENST00000456793.1
oligosaccharyltransferase 4 homolog (S. cerevisiae)
chr19_-_36545649 0.28 ENST00000292894.1
THAP domain containing 8
chr21_-_33984888 0.28 ENST00000382549.4
ENST00000540881.1
chromosome 21 open reading frame 59
chr12_+_6494285 0.27 ENST00000541102.1
lymphotoxin beta receptor (TNFR superfamily, member 3)
chr10_-_47173994 0.27 ENST00000414655.2
ENST00000545298.1
ENST00000359178.4
ENST00000358140.4
ENST00000503031.1
annexin A8-like 1
long intergenic non-protein coding RNA 842
chr14_+_21156915 0.27 ENST00000397990.4
ENST00000555597.1
angiogenin, ribonuclease, RNase A family, 5
ribonuclease, RNase A family, 4
chr1_-_153013588 0.27 ENST00000360379.3
small proline-rich protein 2D
chr2_-_42160486 0.27 ENST00000427054.1
AC104654.2
chr17_+_68071389 0.27 ENST00000283936.1
ENST00000392671.1
potassium inwardly-rectifying channel, subfamily J, member 16
chr10_+_7745303 0.26 ENST00000429820.1
ENST00000379587.4
inter-alpha-trypsin inhibitor heavy chain 2
chr1_+_149230680 0.26 ENST00000443018.1
RP11-403I13.5
chr8_+_145162629 0.26 ENST00000323662.8
KIAA1875
chr16_+_30671223 0.26 ENST00000568722.1
fibrosin
chr3_-_42003613 0.26 ENST00000414606.1
unc-51 like kinase 4
chr9_-_22009241 0.26 ENST00000380142.4
cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
chr6_+_29910301 0.26 ENST00000376809.5
ENST00000376802.2
major histocompatibility complex, class I, A
chr3_-_128712955 0.26 ENST00000265068.5
KIAA1257
chr17_+_7482785 0.25 ENST00000250092.6
ENST00000380498.6
ENST00000584502.1
CD68 molecule
chr15_+_42694573 0.25 ENST00000397200.4
ENST00000569827.1
calpain 3, (p94)
chr19_-_5680231 0.25 ENST00000587950.1
chromosome 19 open reading frame 70
chr8_+_22414182 0.24 ENST00000524057.1
sorbin and SH3 domain containing 3
chrX_+_153665248 0.24 ENST00000447750.2
GDP dissociation inhibitor 1
chr19_+_843314 0.24 ENST00000544537.2
proteinase 3
chr11_-_5537920 0.24 ENST00000380184.1
ubiquilin-like
chr7_-_99573677 0.24 ENST00000292401.4
alpha-2-glycoprotein 1, zinc-binding
chr11_-_119993734 0.24 ENST00000533302.1
tripartite motif containing 29
chr17_+_34171081 0.24 ENST00000585577.1
TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
chr7_-_102119342 0.23 ENST00000393794.3
ENST00000292614.5
polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa
chr2_-_182545603 0.23 ENST00000295108.3
neuronal differentiation 1
chr7_-_135412925 0.23 ENST00000354042.4
solute carrier family 13 (sodium/sulfate symporter), member 4
chr7_+_30174668 0.23 ENST00000415604.1
maturin, neural progenitor differentiation regulator homolog (Xenopus)
chr12_-_95397442 0.23 ENST00000547157.1
ENST00000547986.1
ENST00000327772.2
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12
chrX_+_44732757 0.23 ENST00000377967.4
ENST00000536777.1
ENST00000382899.4
ENST00000543216.1
lysine (K)-specific demethylase 6A
chr12_-_50616382 0.23 ENST00000552783.1
LIM domain and actin binding 1
chr1_+_6845497 0.23 ENST00000473578.1
ENST00000557126.1
calmodulin binding transcription activator 1
chr6_-_47010061 0.23 ENST00000371253.2
G protein-coupled receptor 110
chr2_+_220379052 0.23 ENST00000347842.3
ENST00000358078.4
acid-sensing (proton-gated) ion channel family member 4
chr17_+_18380051 0.23 ENST00000581545.1
ENST00000582333.1
ENST00000328114.6
ENST00000412421.2
ENST00000583322.1
ENST00000584941.1
lectin, galactoside-binding, soluble, 9C
chr11_+_67250490 0.22 ENST00000528641.2
ENST00000279146.3
aryl hydrocarbon receptor interacting protein
chr11_-_64511789 0.22 ENST00000419843.1
ENST00000394430.1
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
chr5_-_127418573 0.22 ENST00000508353.1
ENST00000508878.1
ENST00000501652.1
ENST00000514409.1
CTC-228N24.3
chr20_-_2821756 0.22 ENST00000356872.3
ENST00000439542.1
PC-esterase domain containing 1A
chr8_+_87111059 0.22 ENST00000285393.3
ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2
chr15_-_74726283 0.22 ENST00000543145.2
semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
chr15_+_75639951 0.22 ENST00000564784.1
ENST00000569035.1
nei endonuclease VIII-like 1 (E. coli)
chr17_+_76126842 0.21 ENST00000590426.1
ENST00000590799.1
ENST00000318430.5
ENST00000589691.1
transmembrane channel-like 8
chr1_+_6845578 0.21 ENST00000467404.2
ENST00000439411.2
calmodulin binding transcription activator 1
chr3_-_52008016 0.21 ENST00000489595.2
ENST00000461108.1
ENST00000395008.2
ENST00000525795.1
ENST00000361143.5
Poly(rC)-binding protein 4
abhydrolase domain containing 14B
chr9_-_74979420 0.21 ENST00000343431.2
ENST00000376956.3
zinc finger, AN1-type domain 5
chrX_+_13707235 0.21 ENST00000464506.1
RAB9A, member RAS oncogene family
chr19_+_41497178 0.21 ENST00000324071.4
cytochrome P450, family 2, subfamily B, polypeptide 6
chrX_-_15332665 0.21 ENST00000537676.1
ENST00000344384.4
ankyrin repeat and SOCS box containing 11
chr1_+_202183200 0.21 ENST00000439764.2
leucine-rich repeat containing G protein-coupled receptor 6
chr3_+_48481658 0.20 ENST00000438607.2
translation machinery associated 7 homolog (S. cerevisiae)
chr17_+_45810594 0.20 ENST00000177694.1
T-box 21
chr6_+_32821924 0.20 ENST00000374859.2
ENST00000453265.2
proteasome (prosome, macropain) subunit, beta type, 9
chr8_-_101734170 0.20 ENST00000522387.1
ENST00000518196.1
poly(A) binding protein, cytoplasmic 1
chr21_-_33984865 0.20 ENST00000458138.1
chromosome 21 open reading frame 59
chr15_+_81475047 0.20 ENST00000559388.1
interleukin 16
chr15_-_40401062 0.20 ENST00000354670.4
ENST00000559701.1
ENST00000557870.1
ENST00000558774.1
Bcl2 modifying factor
chr6_-_47009996 0.19 ENST00000371243.2
G protein-coupled receptor 110
chr9_-_34458531 0.19 ENST00000379089.1
ENST00000379087.1
ENST00000379084.1
ENST00000379081.1
ENST00000379080.1
ENST00000422409.1
ENST00000379078.1
ENST00000445726.1
ENST00000297620.4
family with sequence similarity 219, member A
chr9_+_109694914 0.19 ENST00000542028.1
zinc finger protein 462
chr7_-_150780487 0.19 ENST00000482202.1
transmembrane and ubiquitin-like domain containing 1
chr8_-_90769422 0.19 ENST00000524190.1
ENST00000523859.1
RP11-37B2.1
chr19_+_16435625 0.19 ENST00000248071.5
ENST00000592003.1
Kruppel-like factor 2
chr10_+_23384435 0.19 ENST00000376510.3
methionine sulfoxide reductase B2
chr7_-_22862406 0.19 ENST00000372879.4
translocase of outer mitochondrial membrane 7 homolog (yeast)
chr11_-_93474645 0.19 ENST00000532455.1
TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
chr20_+_32399093 0.18 ENST00000217402.2
charged multivesicular body protein 4B
chr12_-_54978086 0.18 ENST00000553113.1
protein phosphatase 1, regulatory (inhibitor) subunit 1A
chr1_-_35497506 0.18 ENST00000317538.5
ENST00000373340.2
ENST00000357182.4
zinc finger, MYM-type 6
chr1_+_116519112 0.18 ENST00000369503.4
solute carrier family 22, member 15
chr7_+_29234375 0.18 ENST00000409350.1
ENST00000495789.2
ENST00000539389.1
chimerin 2
chr12_-_21927736 0.18 ENST00000240662.2
potassium inwardly-rectifying channel, subfamily J, member 8
chr7_+_99971129 0.18 ENST00000394000.2
ENST00000350573.2
paired immunoglobin-like type 2 receptor alpha
chrX_-_73051037 0.18 ENST00000445814.1
X inactive specific transcript (non-protein coding)
chr1_+_155146318 0.18 ENST00000368385.4
ENST00000545012.1
ENST00000392451.2
ENST00000368383.3
ENST00000368382.1
ENST00000334634.4
tripartite motif containing 46
chr17_+_38083977 0.18 ENST00000578802.1
ENST00000578478.1
ENST00000582263.1
RP11-387H17.4
chr1_+_35247859 0.18 ENST00000373362.3
gap junction protein, beta 3, 31kDa
chr12_-_21928515 0.18 ENST00000537950.1
potassium inwardly-rectifying channel, subfamily J, member 8
chr4_-_52883786 0.18 ENST00000343457.3
leucine rich repeat containing 66
chr9_-_23821842 0.17 ENST00000544538.1
ELAV like neuron-specific RNA binding protein 2
chr6_+_37012607 0.17 ENST00000423336.1
cytochrome c oxidase subunit VIa polypeptide 1 pseudogene 2
chr3_+_50192457 0.17 ENST00000414301.1
ENST00000450338.1
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
chrX_-_49965663 0.17 ENST00000376056.2
ENST00000376058.2
ENST00000358526.2
A kinase (PRKA) anchor protein 4
chr17_+_43238438 0.17 ENST00000593138.1
ENST00000586681.1
hexamethylene bis-acetamide inducible 2
chr3_+_177159695 0.17 ENST00000442937.1
long intergenic non-protein coding RNA 578
chr22_+_38453378 0.17 ENST00000437453.1
ENST00000356976.3
protein interacting with PRKCA 1
chr20_+_2821340 0.17 ENST00000380445.3
ENST00000380469.3
vacuolar protein sorting 16 homolog (S. cerevisiae)
chr3_-_100551141 0.17 ENST00000478235.1
ENST00000471901.1
ABI family, member 3 (NESH) binding protein
chr7_-_120498357 0.17 ENST00000415871.1
ENST00000222747.3
ENST00000430985.1
tetraspanin 12
chr19_+_36266417 0.17 ENST00000378944.5
ENST00000007510.4
Rho GTPase activating protein 33
chrY_+_15418467 0.17 ENST00000595988.1
Uncharacterized protein
chr7_-_128415844 0.17 ENST00000249389.2
opsin 1 (cone pigments), short-wave-sensitive
chr5_+_140810132 0.17 ENST00000252085.3
protocadherin gamma subfamily A, 12
chr6_+_42928485 0.17 ENST00000372808.3
glycine N-methyltransferase
chr19_+_16999654 0.17 ENST00000248076.3
coagulation factor II (thrombin) receptor-like 3
chr18_+_28898052 0.17 ENST00000257192.4
desmoglein 1
chr3_+_48507210 0.16 ENST00000433541.1
ENST00000422277.2
ENST00000436480.2
ENST00000444177.1
three prime repair exonuclease 1
chr11_-_118047376 0.16 ENST00000278947.5
sodium channel, voltage-gated, type II, beta subunit
chr17_-_74137374 0.16 ENST00000322957.6
forkhead box J1
chr15_-_85259294 0.16 ENST00000558217.1
ENST00000558196.1
ENST00000558134.1
SEC11 homolog A (S. cerevisiae)
chr1_+_211433275 0.16 ENST00000367005.4
REST corepressor 3
chr9_+_5890802 0.16 ENST00000381477.3
ENST00000381476.1
ENST00000381471.1
melan-A
chr7_+_129007964 0.16 ENST00000460109.1
ENST00000474594.1
ENST00000446212.1
adenosylhomocysteinase-like 2
chrX_-_103087136 0.16 ENST00000243298.2
RAB9B, member RAS oncogene family
chr15_+_90895471 0.16 ENST00000354377.3
ENST00000379090.5
zinc finger protein 774
chr4_+_156680518 0.16 ENST00000513437.1
guanylate cyclase 1, soluble, beta 3
chr17_+_68071458 0.16 ENST00000589377.1
potassium inwardly-rectifying channel, subfamily J, member 16
chr15_+_89402148 0.16 ENST00000560601.1
aggrecan
chr19_+_17337473 0.16 ENST00000598068.1
occludin/ELL domain containing 1
chr6_-_30080876 0.16 ENST00000376734.3
tripartite motif containing 31
chr3_-_50541028 0.16 ENST00000266039.3
ENST00000435965.1
ENST00000395083.1
calcium channel, voltage-dependent, alpha 2/delta subunit 2
chr1_+_210111534 0.15 ENST00000422431.1
ENST00000534859.1
ENST00000399639.2
ENST00000537238.1
synaptotagmin XIV
chr17_-_46507537 0.15 ENST00000336915.6
src kinase associated phosphoprotein 1
chr19_+_37407351 0.15 ENST00000455427.2
ENST00000587857.1
zinc finger protein 568
chr12_+_71833550 0.15 ENST00000266674.5
leucine-rich repeat containing G protein-coupled receptor 5
chr5_+_110407390 0.15 ENST00000344895.3
thymic stromal lymphopoietin
chr3_+_177545563 0.15 ENST00000434309.1
RP11-91K9.1
chr2_+_232572361 0.15 ENST00000409321.1
prothymosin, alpha
chr21_+_33671160 0.15 ENST00000303645.5
melanocortin 2 receptor accessory protein
chr9_+_34458851 0.15 ENST00000545019.1
dynein, axonemal, intermediate chain 1

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX3-2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:2000974 auditory receptor cell fate determination(GO:0042668) negative regulation of pro-B cell differentiation(GO:2000974)
0.3 0.8 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
0.2 0.6 GO:0001798 positive regulation of type IIa hypersensitivity(GO:0001798) positive regulation of type II hypersensitivity(GO:0002894)
0.1 0.4 GO:0002581 negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581)
0.1 0.6 GO:0008588 release of cytoplasmic sequestered NF-kappaB(GO:0008588)
0.1 0.5 GO:0048807 female genitalia morphogenesis(GO:0048807)
0.1 0.2 GO:0060730 regulation of intestinal epithelial structure maintenance(GO:0060730)
0.1 0.3 GO:1902683 regulation of receptor localization to synapse(GO:1902683)
0.1 0.1 GO:0007039 protein catabolic process in the vacuole(GO:0007039)
0.1 0.4 GO:0002906 mature B cell apoptotic process(GO:0002901) regulation of mature B cell apoptotic process(GO:0002905) negative regulation of mature B cell apoptotic process(GO:0002906)
0.1 1.0 GO:0036486 trunk segmentation(GO:0035290) trunk neural crest cell migration(GO:0036484) ventral trunk neural crest cell migration(GO:0036486) neural crest cell migration involved in autonomic nervous system development(GO:1901166)
0.1 0.5 GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316)
0.1 0.4 GO:0010133 proline catabolic process to glutamate(GO:0010133)
0.1 0.2 GO:0002663 B cell tolerance induction(GO:0002514) regulation of B cell tolerance induction(GO:0002661) positive regulation of B cell tolerance induction(GO:0002663)
0.0 0.2 GO:0097029 mature conventional dendritic cell differentiation(GO:0097029)
0.0 0.4 GO:1900625 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.0 0.1 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.0 0.3 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.0 0.6 GO:0015889 cobalamin transport(GO:0015889)
0.0 0.3 GO:0052551 response to defense-related nitric oxide production by other organism involved in symbiotic interaction(GO:0052551) response to defense-related host nitric oxide production(GO:0052565)
0.0 0.2 GO:0070846 misfolded protein transport(GO:0070843) polyubiquitinated protein transport(GO:0070844) polyubiquitinated misfolded protein transport(GO:0070845) Hsp90 deacetylation(GO:0070846)
0.0 0.0 GO:0060349 bone morphogenesis(GO:0060349)
0.0 0.2 GO:0034343 type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344)
0.0 0.2 GO:0071409 cellular response to cycloheximide(GO:0071409)
0.0 0.2 GO:0014718 positive regulation of satellite cell activation involved in skeletal muscle regeneration(GO:0014718)
0.0 0.2 GO:1990523 bone regeneration(GO:1990523)
0.0 0.2 GO:0060024 rhythmic synaptic transmission(GO:0060024)
0.0 0.1 GO:0019859 pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859)
0.0 0.7 GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568)
0.0 0.1 GO:0018352 protein-pyridoxal-5-phosphate linkage(GO:0018352)
0.0 0.2 GO:0090611 ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway(GO:0090611)
0.0 0.1 GO:0032824 negative regulation of natural killer cell differentiation(GO:0032824) negative regulation of natural killer cell differentiation involved in immune response(GO:0032827) positive regulation of cytolysis in other organism(GO:0051714)
0.0 0.3 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.0 0.4 GO:0032074 negative regulation of nuclease activity(GO:0032074)
0.0 0.3 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.0 0.2 GO:0071557 histone H3-K27 demethylation(GO:0071557)
0.0 0.4 GO:1904352 positive regulation of protein catabolic process in the vacuole(GO:1904352)
0.0 0.1 GO:1901594 detection of temperature stimulus involved in thermoception(GO:0050960) response to capsazepine(GO:1901594)
0.0 0.3 GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480)
0.0 0.7 GO:0071481 cellular response to X-ray(GO:0071481)
0.0 0.2 GO:0046684 response to pyrethroid(GO:0046684)
0.0 0.2 GO:0032482 Rab protein signal transduction(GO:0032482)
0.0 0.1 GO:0038163 endomitotic cell cycle(GO:0007113) thrombopoietin-mediated signaling pathway(GO:0038163)
0.0 0.2 GO:0052405 negative regulation by host of symbiont molecular function(GO:0052405)
0.0 0.1 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.0 0.5 GO:0033617 mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.0 0.1 GO:0061153 trachea submucosa development(GO:0061152) trachea gland development(GO:0061153)
0.0 0.2 GO:0038060 nitric oxide-cGMP-mediated signaling pathway(GO:0038060)
0.0 0.1 GO:0071603 endothelial cell-cell adhesion(GO:0071603)
0.0 0.1 GO:0046967 cytosol to ER transport(GO:0046967)
0.0 0.3 GO:2001013 epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013)
0.0 0.4 GO:1990573 potassium ion import across plasma membrane(GO:1990573)
0.0 0.5 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
0.0 0.5 GO:0036158 outer dynein arm assembly(GO:0036158)
0.0 1.1 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.0 0.8 GO:1903846 positive regulation of transforming growth factor beta receptor signaling pathway(GO:0030511) positive regulation of cellular response to transforming growth factor beta stimulus(GO:1903846)
0.0 0.1 GO:0010836 negative regulation of protein ADP-ribosylation(GO:0010836)
0.0 0.1 GO:0051935 amino acid neurotransmitter reuptake(GO:0051933) glutamate reuptake(GO:0051935)
0.0 0.2 GO:1904030 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.0 0.2 GO:0022417 protein maturation by protein folding(GO:0022417)
0.0 0.2 GO:0045040 protein import into mitochondrial outer membrane(GO:0045040)
0.0 0.1 GO:0071351 interleukin-18-mediated signaling pathway(GO:0035655) interleukin-33-mediated signaling pathway(GO:0038172) cellular response to interleukin-18(GO:0071351)
0.0 0.3 GO:0008228 opsonization(GO:0008228)
0.0 0.4 GO:0060670 branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.0 0.1 GO:0001828 inner cell mass cell fate commitment(GO:0001827) inner cell mass cellular morphogenesis(GO:0001828)
0.0 1.2 GO:0018149 peptide cross-linking(GO:0018149)
0.0 0.1 GO:0070346 positive regulation of fat cell proliferation(GO:0070346) positive regulation of cell chemotaxis to fibroblast growth factor(GO:1904849) positive regulation of endothelial cell chemotaxis to fibroblast growth factor(GO:2000546)
0.0 0.2 GO:0099612 protein localization to axon(GO:0099612)
0.0 0.6 GO:0010107 potassium ion import(GO:0010107)
0.0 0.2 GO:0030091 protein repair(GO:0030091)
0.0 0.1 GO:0045919 positive regulation of cytolysis(GO:0045919)
0.0 0.2 GO:0042738 exogenous drug catabolic process(GO:0042738)
0.0 0.2 GO:1904936 cerebral cortex tangential migration(GO:0021800) cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.0 0.1 GO:2000690 regulation of cardiac muscle cell myoblast differentiation(GO:2000690) negative regulation of cardiac muscle cell myoblast differentiation(GO:2000691)
0.0 0.0 GO:0036058 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060) negative regulation of retinal ganglion cell axon guidance(GO:0090260)
0.0 0.1 GO:0016240 autophagosome docking(GO:0016240)
0.0 0.1 GO:0002396 MHC protein complex assembly(GO:0002396) MHC class II protein complex assembly(GO:0002399)
0.0 0.1 GO:0070171 negative regulation of tooth mineralization(GO:0070171)
0.0 0.2 GO:0018298 protein-chromophore linkage(GO:0018298)
0.0 0.2 GO:0006883 cellular sodium ion homeostasis(GO:0006883)
0.0 0.1 GO:0009744 response to sucrose(GO:0009744) response to disaccharide(GO:0034285)
0.0 0.2 GO:0090493 dopamine uptake involved in synaptic transmission(GO:0051583) catecholamine uptake involved in synaptic transmission(GO:0051934) catecholamine uptake(GO:0090493) dopamine uptake(GO:0090494)
0.0 0.1 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091)
0.0 0.0 GO:0010986 positive regulation of lipoprotein particle clearance(GO:0010986)
0.0 0.1 GO:0007402 ganglion mother cell fate determination(GO:0007402)
0.0 0.1 GO:0098912 membrane depolarization during atrial cardiac muscle cell action potential(GO:0098912) positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
0.0 0.6 GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0035774)
0.0 0.1 GO:0009256 10-formyltetrahydrofolate metabolic process(GO:0009256)
0.0 0.2 GO:0060155 platelet dense granule organization(GO:0060155)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.1 0.8 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.1 0.7 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.1 0.7 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.1 0.2 GO:0005668 RNA polymerase transcription factor SL1 complex(GO:0005668)
0.0 0.4 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.0 0.3 GO:0032311 angiogenin-PRI complex(GO:0032311)
0.0 0.3 GO:0016013 syntrophin complex(GO:0016013)
0.0 0.5 GO:0036157 outer dynein arm(GO:0036157)
0.0 0.1 GO:0008623 CHRAC(GO:0008623)
0.0 0.1 GO:0071821 FANCM-MHF complex(GO:0071821)
0.0 0.7 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.3 GO:0005787 signal peptidase complex(GO:0005787)
0.0 0.2 GO:1990769 proximal neuron projection(GO:1990769)
0.0 0.2 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.0 0.2 GO:1990111 spermatoproteasome complex(GO:1990111)
0.0 0.5 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 0.1 GO:1990131 Gtr1-Gtr2 GTPase complex(GO:1990131)
0.0 0.1 GO:0010370 perinucleolar chromocenter(GO:0010370)
0.0 0.3 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 0.1 GO:0070695 FHF complex(GO:0070695)
0.0 0.2 GO:0061689 tricellular tight junction(GO:0061689)
0.0 0.1 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.0 0.3 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.0 0.1 GO:0097629 extrinsic component of omegasome membrane(GO:0097629)
0.0 0.5 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 0.2 GO:0044666 MLL3/4 complex(GO:0044666)
0.0 0.2 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.0 0.0 GO:0005674 transcription factor TFIIF complex(GO:0005674)
0.0 0.5 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 0.1 GO:0005863 striated muscle myosin thick filament(GO:0005863)
0.0 0.2 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 1.0 GO:0001533 cornified envelope(GO:0001533)
0.0 0.1 GO:0097013 phagocytic vesicle lumen(GO:0097013)
0.0 0.0 GO:0097224 sperm connecting piece(GO:0097224)
0.0 0.3 GO:0005839 proteasome core complex(GO:0005839)
0.0 0.1 GO:0042825 TAP complex(GO:0042825)
0.0 0.1 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.0 0.2 GO:0000815 ESCRT III complex(GO:0000815)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0008160 protein tyrosine phosphatase activator activity(GO:0008160)
0.1 0.4 GO:0050613 delta14-sterol reductase activity(GO:0050613)
0.1 0.4 GO:0004657 proline dehydrogenase activity(GO:0004657)
0.1 0.4 GO:0017098 sulfonylurea receptor binding(GO:0017098)
0.1 0.4 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
0.1 0.2 GO:0005334 norepinephrine:sodium symporter activity(GO:0005334)
0.0 0.1 GO:0031783 corticotropin hormone receptor binding(GO:0031780) type 5 melanocortin receptor binding(GO:0031783)
0.0 0.4 GO:0042289 MHC class II protein binding(GO:0042289)
0.0 0.6 GO:0031419 cobalamin binding(GO:0031419)
0.0 0.6 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.0 1.3 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0 1.0 GO:0045499 chemorepellent activity(GO:0045499)
0.0 0.3 GO:0004522 ribonuclease A activity(GO:0004522)
0.0 0.1 GO:0002113 interleukin-33 binding(GO:0002113)
0.0 0.1 GO:0004487 methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487)
0.0 0.3 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0 0.8 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 0.5 GO:0038132 neuregulin binding(GO:0038132)
0.0 0.5 GO:0032395 MHC class II receptor activity(GO:0032395)
0.0 0.1 GO:0004948 calcitonin receptor activity(GO:0004948)
0.0 0.1 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.0 0.1 GO:0004464 leukotriene-C4 synthase activity(GO:0004464)
0.0 0.3 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.0 0.2 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.0 0.2 GO:0050682 AF-2 domain binding(GO:0050682)
0.0 0.5 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.2 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.0 0.2 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.0 1.9 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.0 0.1 GO:0005333 norepinephrine transmembrane transporter activity(GO:0005333)
0.0 0.5 GO:0001055 RNA polymerase II activity(GO:0001055)
0.0 0.1 GO:0008427 calcium-dependent protein kinase inhibitor activity(GO:0008427)
0.0 0.2 GO:0042903 tubulin deacetylase activity(GO:0042903)
0.0 0.1 GO:0004769 steroid delta-isomerase activity(GO:0004769)
0.0 0.6 GO:0016918 retinal binding(GO:0016918) retinol binding(GO:0019841)
0.0 0.3 GO:0070053 thrombospondin receptor activity(GO:0070053)
0.0 0.1 GO:0008745 N-acetylmuramoyl-L-alanine amidase activity(GO:0008745)
0.0 0.1 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.0 0.5 GO:0045504 dynein heavy chain binding(GO:0045504)
0.0 0.4 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 0.2 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 0.1 GO:0030627 pre-mRNA 5'-splice site binding(GO:0030627)
0.0 0.2 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.0 0.4 GO:0008320 protein transmembrane transporter activity(GO:0008320)
0.0 0.1 GO:0005011 macrophage colony-stimulating factor receptor activity(GO:0005011)
0.0 0.7 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.1 GO:0008457 beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity(GO:0008457) lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity(GO:0047256)
0.0 0.2 GO:0004689 phosphorylase kinase activity(GO:0004689)
0.0 0.2 GO:0033613 activating transcription factor binding(GO:0033613)
0.0 0.3 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.0 0.5 GO:0004383 guanylate cyclase activity(GO:0004383)
0.0 0.1 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.0 0.0 GO:0050146 nucleoside phosphotransferase activity(GO:0050146)
0.0 0.1 GO:0017099 very-long-chain-acyl-CoA dehydrogenase activity(GO:0017099)
0.0 0.1 GO:0097603 temperature-gated ion channel activity(GO:0097603)
0.0 0.3 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.6 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.0 0.4 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.0 0.1 GO:0060698 endoribonuclease inhibitor activity(GO:0060698)
0.0 0.2 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 0.1 GO:0004977 melanocortin receptor activity(GO:0004977)
0.0 0.2 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0 0.3 GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906)
0.0 0.1 GO:1904929 coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway(GO:1904929)
0.0 0.2 GO:0015643 toxic substance binding(GO:0015643)
0.0 0.2 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 0.1 GO:0050119 N-acetylglucosamine deacetylase activity(GO:0050119)
0.0 0.2 GO:0055103 ligase regulator activity(GO:0055103)
0.0 0.1 GO:0046979 TAP2 binding(GO:0046979)
0.0 0.6 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.1 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.0 0.4 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.0 1.5 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.4 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 0.6 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.4 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 1.0 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 0.7 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.0 2.8 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.1 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.6 NABA PROTEOGLYCANS Genes encoding proteoglycans

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 1.3 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.0 0.6 REACTOME INITIAL TRIGGERING OF COMPLEMENT Genes involved in Initial triggering of complement
0.0 0.3 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.0 0.4 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.2 REACTOME OPSINS Genes involved in Opsins
0.0 1.3 REACTOME G1 PHASE Genes involved in G1 Phase
0.0 1.0 REACTOME INWARDLY RECTIFYING K CHANNELS Genes involved in Inwardly rectifying K+ channels
0.0 0.5 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.8 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.0 0.3 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 0.5 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0 0.3 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.0 0.2 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.0 0.3 REACTOME VIRAL MESSENGER RNA SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.0 1.1 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.4 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis