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SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for NKX6-2

Z-value: 0.80

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Transcription factors associated with NKX6-2

Gene Symbol Gene ID Gene Info
NKX6-2
ENSG00000148826.6 NK6 homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NKX6-2hg19_v2_chr10_-_134599556_134599653-0.174.8e-01Click!

Activity profile of NKX6-2 motif

Sorted Z-values of NKX6-2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr5_+_166711804 4.07 ENST00000518659.1
ENST00000545108.1
TENM2
teneurin transmembrane protein 2
chr12_-_28124903 3.55 ENST00000395872.1
ENST00000354417.3
ENST00000201015.4
PTHLH
parathyroid hormone-like hormone
chr1_+_209878182 2.99 ENST00000367027.3
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chr12_+_4385230 2.89 ENST00000536537.1
CCND2
cyclin D2
chr7_-_20256965 2.74 ENST00000400331.5
ENST00000332878.4
MACC1
metastasis associated in colon cancer 1
chr5_+_31193847 2.57 ENST00000514738.1
ENST00000265071.2
CDH6
cadherin 6, type 2, K-cadherin (fetal kidney)
chr1_-_221915418 2.01 ENST00000323825.3
ENST00000366899.3
DUSP10
dual specificity phosphatase 10
chr4_+_169013666 1.98 ENST00000359299.3
ANXA10
annexin A10
chr2_+_210444142 1.93 ENST00000360351.4
ENST00000361559.4
MAP2
microtubule-associated protein 2
chr6_-_113953705 1.90 ENST00000452675.1
RP11-367G18.1
RP11-367G18.1
chr4_+_71384257 1.84 ENST00000339336.4
AMTN
amelotin
chr4_+_71384300 1.79 ENST00000504451.1
AMTN
amelotin
chr2_+_210443993 1.66 ENST00000392193.1
MAP2
microtubule-associated protein 2
chrX_-_80457385 1.24 ENST00000451455.1
ENST00000436386.1
ENST00000358130.2
HMGN5
high mobility group nucleosome binding domain 5
chrX_+_102840408 1.22 ENST00000468024.1
ENST00000472484.1
ENST00000415568.2
ENST00000490644.1
ENST00000459722.1
ENST00000472745.1
ENST00000494801.1
ENST00000434216.2
ENST00000425011.1
TCEAL4
transcription elongation factor A (SII)-like 4
chr10_-_115904361 1.20 ENST00000428953.1
ENST00000543782.1
C10orf118
chromosome 10 open reading frame 118
chr2_+_210444298 1.16 ENST00000445941.1
MAP2
microtubule-associated protein 2
chr1_+_79115503 1.15 ENST00000370747.4
ENST00000438486.1
ENST00000545124.1
IFI44
interferon-induced protein 44
chr1_+_85527987 1.13 ENST00000326813.8
ENST00000294664.6
ENST00000528899.1
WDR63
WD repeat domain 63
chr15_+_49715449 1.09 ENST00000560979.1
FGF7
fibroblast growth factor 7
chr14_+_52164820 1.07 ENST00000554167.1
FRMD6
FERM domain containing 6
chr5_+_145316120 1.03 ENST00000359120.4
SH3RF2
SH3 domain containing ring finger 2
chr1_+_70820451 1.02 ENST00000361764.4
ENST00000359875.5
ENST00000370940.5
ENST00000531950.1
ENST00000432224.1
HHLA3
HERV-H LTR-associating 3
chr3_-_74570291 1.01 ENST00000263665.6
CNTN3
contactin 3 (plasmacytoma associated)
chr3_-_79816965 0.94 ENST00000464233.1
ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chrX_+_105936982 0.93 ENST00000418562.1
RNF128
ring finger protein 128, E3 ubiquitin protein ligase
chr6_-_56716686 0.90 ENST00000520645.1
DST
dystonin
chr3_+_156799587 0.88 ENST00000469196.1
RP11-6F2.5
RP11-6F2.5
chrX_+_105937068 0.87 ENST00000324342.3
RNF128
ring finger protein 128, E3 ubiquitin protein ligase
chr14_+_52164675 0.85 ENST00000555936.1
FRMD6
FERM domain containing 6
chr9_+_109685630 0.84 ENST00000451160.2
RP11-508N12.4
Uncharacterized protein
chr18_+_42260059 0.82 ENST00000426838.4
SETBP1
SET binding protein 1
chr8_+_97597148 0.78 ENST00000521590.1
SDC2
syndecan 2
chr6_-_26199499 0.77 ENST00000377831.5
HIST1H3D
histone cluster 1, H3d
chr12_+_32655048 0.77 ENST00000427716.2
ENST00000266482.3
FGD4
FYVE, RhoGEF and PH domain containing 4
chr16_-_4852915 0.77 ENST00000322048.7
ROGDI
rogdi homolog (Drosophila)
chr9_-_71869642 0.76 ENST00000600472.1
AL358113.1
Tight junction protein 2 (Zona occludens 2) isoform 1 variant; Uncharacterized protein
chr3_-_138048682 0.76 ENST00000383180.2
NME9
NME/NM23 family member 9
chr8_-_42358742 0.76 ENST00000517366.1
SLC20A2
solute carrier family 20 (phosphate transporter), member 2
chr1_+_78383813 0.75 ENST00000342754.5
NEXN
nexilin (F actin binding protein)
chr6_-_26199471 0.73 ENST00000341023.1
HIST1H2AD
histone cluster 1, H2ad
chr1_+_196621002 0.71 ENST00000367429.4
ENST00000439155.2
CFH
complement factor H
chr4_+_26324474 0.70 ENST00000514675.1
RBPJ
recombination signal binding protein for immunoglobulin kappa J region
chr2_-_208030295 0.70 ENST00000458272.1
KLF7
Kruppel-like factor 7 (ubiquitous)
chr6_+_15401075 0.70 ENST00000541660.1
JARID2
jumonji, AT rich interactive domain 2
chr15_+_93443419 0.70 ENST00000557381.1
ENST00000420239.2
CHD2
chromodomain helicase DNA binding protein 2
chr12_+_32655110 0.68 ENST00000546442.1
ENST00000583694.1
FGD4
FYVE, RhoGEF and PH domain containing 4
chr3_-_71294304 0.68 ENST00000498215.1
FOXP1
forkhead box P1
chr18_-_47018769 0.66 ENST00000583637.1
ENST00000578528.1
ENST00000578532.1
ENST00000580387.1
ENST00000579248.1
ENST00000581373.1
RPL17
ribosomal protein L17
chr18_-_47018897 0.65 ENST00000418495.1
RPL17
ribosomal protein L17
chr8_-_57123815 0.64 ENST00000316981.3
ENST00000423799.2
ENST00000429357.2
PLAG1
pleiomorphic adenoma gene 1
chr3_-_141747439 0.63 ENST00000467667.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr4_-_110723194 0.62 ENST00000394635.3
CFI
complement factor I
chr8_+_104831472 0.62 ENST00000262231.10
ENST00000507740.1
RIMS2
regulating synaptic membrane exocytosis 2
chr1_-_21377447 0.57 ENST00000374937.3
ENST00000264211.8
EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr2_-_208030886 0.57 ENST00000426163.1
KLF7
Kruppel-like factor 7 (ubiquitous)
chr6_+_47666275 0.56 ENST00000327753.3
ENST00000283303.2
GPR115
G protein-coupled receptor 115
chrX_+_55744228 0.56 ENST00000262850.7
RRAGB
Ras-related GTP binding B
chr12_-_122241812 0.56 ENST00000538335.1
AC084018.1
AC084018.1
chr1_-_110155671 0.56 ENST00000351050.3
GNAT2
guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
chr7_+_107224364 0.55 ENST00000491150.1
BCAP29
B-cell receptor-associated protein 29
chr1_+_174933899 0.54 ENST00000367688.3
RABGAP1L
RAB GTPase activating protein 1-like
chr19_+_12175596 0.54 ENST00000441304.2
ZNF844
zinc finger protein 844
chr1_+_201617264 0.53 ENST00000367296.4
NAV1
neuron navigator 1
chr18_+_76829441 0.53 ENST00000458297.2
ATP9B
ATPase, class II, type 9B
chr12_-_74686314 0.53 ENST00000551210.1
ENST00000515416.2
ENST00000549905.1
RP11-81H3.2
RP11-81H3.2
chr17_-_56494908 0.52 ENST00000577716.1
RNF43
ring finger protein 43
chr4_-_87374283 0.52 ENST00000361569.2
MAPK10
mitogen-activated protein kinase 10
chr12_+_25205568 0.52 ENST00000548766.1
ENST00000556887.1
LRMP
lymphoid-restricted membrane protein
chr8_+_79428539 0.52 ENST00000352966.5
PKIA
protein kinase (cAMP-dependent, catalytic) inhibitor alpha
chr1_+_201617450 0.52 ENST00000295624.6
ENST00000367297.4
ENST00000367300.3
NAV1
neuron navigator 1
chr21_-_27462351 0.51 ENST00000448850.1
APP
amyloid beta (A4) precursor protein
chr18_-_47018869 0.51 ENST00000583036.1
ENST00000580261.1
RPL17
ribosomal protein L17
chr11_-_8892900 0.50 ENST00000526155.1
ENST00000524757.1
ENST00000527392.1
ENST00000534665.1
ENST00000525169.1
ENST00000527516.1
ENST00000533471.1
ST5
suppression of tumorigenicity 5
chr12_+_14561422 0.50 ENST00000541056.1
ATF7IP
activating transcription factor 7 interacting protein
chr7_+_18536090 0.49 ENST00000441986.1
HDAC9
histone deacetylase 9
chr1_-_17766198 0.47 ENST00000375436.4
RCC2
regulator of chromosome condensation 2
chr1_+_174670143 0.47 ENST00000367687.1
ENST00000347255.2
RABGAP1L
RAB GTPase activating protein 1-like
chr3_-_141747950 0.46 ENST00000497579.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr17_-_56494882 0.46 ENST00000584437.1
RNF43
ring finger protein 43
chrX_+_55744166 0.46 ENST00000374941.4
ENST00000414239.1
RRAGB
Ras-related GTP binding B
chr17_-_56494713 0.45 ENST00000407977.2
RNF43
ring finger protein 43
chr14_+_101295638 0.45 ENST00000523671.2
MEG3
maternally expressed 3 (non-protein coding)
chr1_-_149858227 0.44 ENST00000369155.2
HIST2H2BE
histone cluster 2, H2be
chr4_+_100495864 0.44 ENST00000265517.5
ENST00000422897.2
MTTP
microsomal triglyceride transfer protein
chr6_-_80247140 0.43 ENST00000392959.1
ENST00000467898.3
LCA5
Leber congenital amaurosis 5
chr20_+_57467204 0.43 ENST00000603546.1
GNAS
GNAS complex locus
chr13_-_45048386 0.43 ENST00000472477.1
TSC22D1
TSC22 domain family, member 1
chr15_+_79166065 0.42 ENST00000559690.1
ENST00000559158.1
MORF4L1
mortality factor 4 like 1
chr18_-_53255379 0.42 ENST00000565908.2
TCF4
transcription factor 4
chr20_-_7921090 0.42 ENST00000378789.3
HAO1
hydroxyacid oxidase (glycolate oxidase) 1
chr6_-_80247105 0.42 ENST00000369846.4
LCA5
Leber congenital amaurosis 5
chr1_-_226926864 0.41 ENST00000429204.1
ENST00000366784.1
ITPKB
inositol-trisphosphate 3-kinase B
chr3_+_51575596 0.39 ENST00000409535.2
RAD54L2
RAD54-like 2 (S. cerevisiae)
chr19_+_54641444 0.37 ENST00000221232.5
ENST00000358389.3
CNOT3
CCR4-NOT transcription complex, subunit 3
chr22_+_46476192 0.36 ENST00000443490.1
FLJ27365
hsa-mir-4763
chr16_+_70695570 0.36 ENST00000597002.1
FLJ00418
FLJ00418
chr2_-_207024233 0.36 ENST00000423725.1
ENST00000233190.6
NDUFS1
NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
chr6_+_158733692 0.35 ENST00000367094.2
ENST00000367097.3
TULP4
tubby like protein 4
chr2_+_68961934 0.34 ENST00000409202.3
ARHGAP25
Rho GTPase activating protein 25
chr4_-_23891693 0.34 ENST00000264867.2
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr19_+_12175504 0.34 ENST00000439326.3
ZNF844
zinc finger protein 844
chr17_-_60885659 0.34 ENST00000311269.5
MARCH10
membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase
chr18_+_32290218 0.34 ENST00000348997.5
ENST00000588949.1
ENST00000597599.1
DTNA
dystrobrevin, alpha
chr14_+_86401039 0.33 ENST00000557195.1
CTD-2341M24.1
CTD-2341M24.1
chr12_+_40787194 0.33 ENST00000425730.2
ENST00000454784.4
MUC19
mucin 19, oligomeric
chr10_+_26505179 0.33 ENST00000376261.3
GAD2
glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
chr4_+_188916918 0.32 ENST00000509524.1
ENST00000326866.4
ZFP42
ZFP42 zinc finger protein
chr2_-_208030647 0.32 ENST00000309446.6
KLF7
Kruppel-like factor 7 (ubiquitous)
chr5_+_67586465 0.32 ENST00000336483.5
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr17_-_60885645 0.31 ENST00000544856.2
MARCH10
membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase
chr17_-_60885700 0.31 ENST00000583600.1
MARCH10
membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase
chr5_+_95066823 0.31 ENST00000506817.1
ENST00000379982.3
RHOBTB3
Rho-related BTB domain containing 3
chr2_+_68961905 0.31 ENST00000295381.3
ARHGAP25
Rho GTPase activating protein 25
chr1_-_116383322 0.30 ENST00000429731.1
NHLH2
nescient helix loop helix 2
chr8_-_72268721 0.30 ENST00000419131.1
ENST00000388743.2
EYA1
eyes absent homolog 1 (Drosophila)
chr20_+_42136308 0.29 ENST00000434666.1
ENST00000427442.2
ENST00000439769.1
ENST00000418998.1
L3MBTL1
l(3)mbt-like 1 (Drosophila)
chr2_+_68962014 0.29 ENST00000467265.1
ARHGAP25
Rho GTPase activating protein 25
chr3_-_193272874 0.28 ENST00000342695.4
ATP13A4
ATPase type 13A4
chr2_+_218990727 0.28 ENST00000318507.2
ENST00000454148.1
CXCR2
chemokine (C-X-C motif) receptor 2
chr18_+_32402321 0.27 ENST00000587723.1
DTNA
dystrobrevin, alpha
chr1_+_244624678 0.27 ENST00000366534.4
ENST00000366533.4
ENST00000428042.1
ENST00000366531.3
C1orf101
chromosome 1 open reading frame 101
chr7_-_102184083 0.27 ENST00000379357.5
POLR2J3
polymerase (RNA) II (DNA directed) polypeptide J3
chr12_-_94673956 0.26 ENST00000551941.1
RP11-1105G2.3
Uncharacterized protein
chr10_+_50887683 0.25 ENST00000374113.3
ENST00000374111.3
ENST00000374112.3
ENST00000535836.1
C10orf53
chromosome 10 open reading frame 53
chr9_-_23825956 0.25 ENST00000397312.2
ELAVL2
ELAV like neuron-specific RNA binding protein 2
chr10_+_91589309 0.24 ENST00000448490.1
LINC00865
long intergenic non-protein coding RNA 865
chr5_-_13944652 0.24 ENST00000265104.4
DNAH5
dynein, axonemal, heavy chain 5
chr2_+_179149636 0.24 ENST00000409631.1
OSBPL6
oxysterol binding protein-like 6
chr11_+_57529234 0.24 ENST00000360682.6
ENST00000361796.4
ENST00000529526.1
ENST00000426142.2
ENST00000399050.4
ENST00000361391.6
ENST00000361332.4
ENST00000532463.1
ENST00000529986.1
ENST00000358694.6
ENST00000532787.1
ENST00000533667.1
ENST00000532649.1
ENST00000528621.1
ENST00000530748.1
ENST00000428599.2
ENST00000527467.1
ENST00000528232.1
ENST00000531014.1
ENST00000526772.1
ENST00000529873.1
ENST00000525902.1
ENST00000532844.1
ENST00000526357.1
ENST00000530094.1
ENST00000415361.2
ENST00000532245.1
ENST00000534579.1
ENST00000526938.1
CTNND1
catenin (cadherin-associated protein), delta 1
chr2_+_218989991 0.24 ENST00000453237.1
CXCR2
chemokine (C-X-C motif) receptor 2
chr11_-_94706705 0.24 ENST00000279839.6
CWC15
CWC15 spliceosome-associated protein homolog (S. cerevisiae)
chr16_+_14841923 0.24 ENST00000530328.1
ENST00000529166.1
NPIPA2
nuclear pore complex interacting protein family, member A2
chr18_-_12656715 0.23 ENST00000462226.1
ENST00000497844.2
ENST00000309836.5
ENST00000453447.2
SPIRE1
spire-type actin nucleation factor 1
chr12_+_122241928 0.23 ENST00000604567.1
ENST00000542440.1
SETD1B
SET domain containing 1B
chr9_-_23826298 0.22 ENST00000380117.1
ELAVL2
ELAV like neuron-specific RNA binding protein 2
chr8_+_104831554 0.22 ENST00000408894.2
RIMS2
regulating synaptic membrane exocytosis 2
chr11_-_26744908 0.22 ENST00000533617.1
SLC5A12
solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12
chr6_+_114178512 0.22 ENST00000368635.4
MARCKS
myristoylated alanine-rich protein kinase C substrate
chr19_+_12175535 0.22 ENST00000550826.1
ZNF844
zinc finger protein 844
chr2_+_207024306 0.21 ENST00000236957.5
ENST00000392221.1
ENST00000392222.2
ENST00000445505.1
EEF1B2
eukaryotic translation elongation factor 1 beta 2
chr10_-_71169031 0.21 ENST00000373307.1
TACR2
tachykinin receptor 2
chr17_-_57232525 0.21 ENST00000583380.1
ENST00000580541.1
ENST00000578105.1
ENST00000437036.2
SKA2
spindle and kinetochore associated complex subunit 2
chr4_-_25865159 0.21 ENST00000502949.1
ENST00000264868.5
ENST00000513691.1
ENST00000514872.1
SEL1L3
sel-1 suppressor of lin-12-like 3 (C. elegans)
chr14_-_99737565 0.20 ENST00000357195.3
BCL11B
B-cell CLL/lymphoma 11B (zinc finger protein)
chr8_+_104831440 0.20 ENST00000515551.1
RIMS2
regulating synaptic membrane exocytosis 2
chr1_+_115397424 0.19 ENST00000369522.3
ENST00000455987.1
SYCP1
synaptonemal complex protein 1
chr19_+_52772821 0.18 ENST00000439461.1
ZNF766
zinc finger protein 766
chr20_+_30697298 0.18 ENST00000398022.2
TM9SF4
transmembrane 9 superfamily protein member 4
chr7_-_84122033 0.18 ENST00000424555.1
SEMA3A
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr2_-_207024134 0.18 ENST00000457011.1
ENST00000440274.1
ENST00000432169.1
NDUFS1
NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
chr18_-_52989217 0.18 ENST00000570287.2
TCF4
transcription factor 4
chr4_-_185139062 0.18 ENST00000296741.2
ENPP6
ectonucleotide pyrophosphatase/phosphodiesterase 6
chr16_-_54972581 0.18 ENST00000559802.1
ENST00000558156.1
CTD-3032H12.1
CTD-3032H12.1
chr15_+_74421961 0.17 ENST00000565159.1
ENST00000567206.1
ISLR2
immunoglobulin superfamily containing leucine-rich repeat 2
chr12_+_111284805 0.17 ENST00000552694.1
CCDC63
coiled-coil domain containing 63
chr12_+_111284764 0.17 ENST00000545036.1
ENST00000308208.5
CCDC63
coiled-coil domain containing 63
chr3_-_141747459 0.17 ENST00000477292.1
ENST00000478006.1
ENST00000495310.1
ENST00000486111.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr6_+_25963020 0.17 ENST00000357085.3
TRIM38
tripartite motif containing 38
chr6_-_46703430 0.17 ENST00000537365.1
PLA2G7
phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
chr7_-_102283238 0.16 ENST00000340457.8
UPK3BL
uroplakin 3B-like
chr1_-_89357179 0.16 ENST00000448623.1
ENST00000418217.1
ENST00000370500.5
GTF2B
general transcription factor IIB
chr18_-_53019208 0.16 ENST00000562607.1
TCF4
transcription factor 4
chr7_-_22233442 0.16 ENST00000401957.2
RAPGEF5
Rap guanine nucleotide exchange factor (GEF) 5
chr1_-_186430222 0.16 ENST00000391997.2
PDC
phosducin
chr4_+_77356248 0.16 ENST00000296043.6
SHROOM3
shroom family member 3
chr1_+_210501589 0.15 ENST00000413764.2
ENST00000541565.1
HHAT
hedgehog acyltransferase
chr1_-_109935819 0.15 ENST00000538502.1
SORT1
sortilin 1
chr16_+_14802801 0.15 ENST00000526520.1
ENST00000531598.2
NPIPA3
nuclear pore complex interacting protein family, member A3
chr10_+_133753533 0.14 ENST00000422256.2
PPP2R2D
protein phosphatase 2, regulatory subunit B, delta
chr5_-_159546396 0.14 ENST00000523662.1
ENST00000456329.3
ENST00000307063.7
PWWP2A
PWWP domain containing 2A
chr8_+_26150628 0.14 ENST00000523925.1
ENST00000315985.7
PPP2R2A
protein phosphatase 2, regulatory subunit B, alpha
chr4_-_108204904 0.14 ENST00000510463.1
DKK2
dickkopf WNT signaling pathway inhibitor 2
chr7_-_115799942 0.14 ENST00000484212.1
TFEC
transcription factor EC
chr11_-_62521614 0.14 ENST00000527994.1
ENST00000394807.3
ZBTB3
zinc finger and BTB domain containing 3
chr3_+_130650738 0.13 ENST00000504612.1
ATP2C1
ATPase, Ca++ transporting, type 2C, member 1
chr5_-_88120083 0.13 ENST00000509373.1
MEF2C
myocyte enhancer factor 2C
chr2_+_218990428 0.13 ENST00000449014.1
CXCR2
chemokine (C-X-C motif) receptor 2
chr5_-_78365437 0.13 ENST00000380311.4
ENST00000540686.1
ENST00000255189.3
DMGDH
dimethylglycine dehydrogenase
chr17_-_40828969 0.12 ENST00000591022.1
ENST00000587627.1
ENST00000293349.6
PLEKHH3
pleckstrin homology domain containing, family H (with MyTH4 domain) member 3
chr4_+_74269956 0.12 ENST00000295897.4
ENST00000415165.2
ENST00000503124.1
ENST00000509063.1
ENST00000401494.3
ALB
albumin
chr13_-_103719196 0.12 ENST00000245312.3
SLC10A2
solute carrier family 10 (sodium/bile acid cotransporter), member 2
chr5_-_111091948 0.12 ENST00000447165.2
NREP
neuronal regeneration related protein
chr5_+_161274940 0.12 ENST00000393943.4
GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr21_-_36421626 0.11 ENST00000300305.3
RUNX1
runt-related transcription factor 1
chr5_+_161274685 0.11 ENST00000428797.2
GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr2_-_207023918 0.11 ENST00000455934.2
ENST00000449699.1
ENST00000454195.1
NDUFS1
NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
chr2_+_218990394 0.11 ENST00000415392.1
CXCR2
chemokine (C-X-C motif) receptor 2
chr10_-_63995871 0.11 ENST00000315289.2
RTKN2
rhotekin 2
chr6_+_12007963 0.10 ENST00000607445.1
RP11-456H18.2
RP11-456H18.2
chr3_-_45838011 0.10 ENST00000358525.4
ENST00000413781.1
SLC6A20
solute carrier family 6 (proline IMINO transporter), member 20
chr17_-_40829026 0.10 ENST00000412503.1
PLEKHH3
pleckstrin homology domain containing, family H (with MyTH4 domain) member 3
chr18_-_52989525 0.10 ENST00000457482.3
TCF4
transcription factor 4
chr3_-_112013071 0.10 ENST00000487372.1
ENST00000486574.1
ENST00000305815.5
SLC9C1
solute carrier family 9, subfamily C (Na+-transporting carboxylic acid decarboxylase), member 1
chrX_+_68835911 0.10 ENST00000525810.1
ENST00000527388.1
ENST00000374553.2
ENST00000374552.4
ENST00000338901.3
ENST00000524573.1
EDA
ectodysplasin A
chr21_-_36421401 0.09 ENST00000486278.2
RUNX1
runt-related transcription factor 1
chr3_+_52245458 0.09 ENST00000459884.1
ALAS1
aminolevulinate, delta-, synthase 1
chr9_+_88556036 0.09 ENST00000361671.5
ENST00000416045.1
NAA35
N(alpha)-acetyltransferase 35, NatC auxiliary subunit
chr16_+_89228757 0.09 ENST00000565008.1
LINC00304
long intergenic non-protein coding RNA 304
chr7_-_140482926 0.09 ENST00000496384.2
BRAF
v-raf murine sarcoma viral oncogene homolog B

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX6-2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 3.6 GO:0070175 positive regulation of enamel mineralization(GO:0070175)
0.4 2.0 GO:0060266 negative regulation of respiratory burst involved in inflammatory response(GO:0060266)
0.3 1.4 GO:0038018 Wnt receptor catabolic process(GO:0038018)
0.2 1.9 GO:0003383 apical constriction(GO:0003383)
0.2 0.9 GO:0021836 cerebral cortex tangential migration using cell-cell interactions(GO:0021823) postnatal olfactory bulb interneuron migration(GO:0021827) chemorepulsion involved in postnatal olfactory bulb interneuron migration(GO:0021836)
0.2 3.7 GO:0097264 self proteolysis(GO:0097264)
0.2 1.0 GO:0060437 lung growth(GO:0060437)
0.2 0.5 GO:0072356 chromosome passenger complex localization to kinetochore(GO:0072356)
0.1 1.8 GO:1904352 positive regulation of protein catabolic process in the vacuole(GO:1904352)
0.1 0.8 GO:0038112 interleukin-8-mediated signaling pathway(GO:0038112)
0.1 3.0 GO:0006704 glucocorticoid biosynthetic process(GO:0006704)
0.1 0.7 GO:0032625 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
0.1 0.8 GO:0008218 bioluminescence(GO:0008218)
0.1 2.9 GO:0071481 cellular response to X-ray(GO:0071481)
0.1 0.5 GO:0071874 cellular response to norepinephrine stimulus(GO:0071874)
0.1 1.0 GO:1990253 cellular response to leucine starvation(GO:1990253)
0.1 0.1 GO:0061152 trachea submucosa development(GO:0061152) trachea gland development(GO:0061153)
0.1 3.5 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)
0.1 0.7 GO:1901297 positive regulation of ephrin receptor signaling pathway(GO:1901189) positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068)
0.1 1.0 GO:0061669 spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814)
0.1 0.2 GO:0033685 negative regulation of luteinizing hormone secretion(GO:0033685)
0.1 0.2 GO:0097535 lymphoid lineage cell migration(GO:0097534) lymphoid lineage cell migration into thymus(GO:0097535)
0.1 0.3 GO:0006540 glutamate decarboxylation to succinate(GO:0006540)
0.1 0.1 GO:0071873 response to norepinephrine(GO:0071873)
0.1 0.2 GO:0000711 meiotic DNA repair synthesis(GO:0000711)
0.1 0.4 GO:0009441 glycolate metabolic process(GO:0009441)
0.1 0.4 GO:0033029 regulation of neutrophil apoptotic process(GO:0033029)
0.1 0.8 GO:0006228 UTP biosynthetic process(GO:0006228)
0.1 0.6 GO:0046549 retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549)
0.0 0.5 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.0 0.8 GO:0008090 retrograde axonal transport(GO:0008090)
0.0 0.4 GO:0040032 post-embryonic body morphogenesis(GO:0040032)
0.0 6.4 GO:0001578 microtubule bundle formation(GO:0001578)
0.0 0.2 GO:1903045 neural crest cell migration involved in sympathetic nervous system development(GO:1903045)
0.0 0.1 GO:0006579 amino-acid betaine catabolic process(GO:0006579)
0.0 0.8 GO:0044341 sodium-dependent phosphate transport(GO:0044341)
0.0 0.8 GO:0048739 cardiac muscle fiber development(GO:0048739)
0.0 0.6 GO:0007258 JUN phosphorylation(GO:0007258)
0.0 0.7 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.0 0.1 GO:0052331 hemolysis by symbiont of host erythrocytes(GO:0019836) hemolysis in other organism(GO:0044179) hemolysis in other organism involved in symbiotic interaction(GO:0052331)
0.0 0.2 GO:1904798 positive regulation of core promoter binding(GO:1904798)
0.0 0.2 GO:0046116 queuosine biosynthetic process(GO:0008616) queuosine metabolic process(GO:0046116)
0.0 0.6 GO:0060252 positive regulation of glial cell proliferation(GO:0060252)
0.0 0.7 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.0 1.3 GO:0071157 negative regulation of cell cycle arrest(GO:0071157)
0.0 0.4 GO:0034378 chylomicron assembly(GO:0034378)
0.0 0.3 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.0 0.2 GO:0040038 polar body extrusion after meiotic divisions(GO:0040038) formin-nucleated actin cable assembly(GO:0070649)
0.0 0.2 GO:0046469 plasma lipoprotein particle oxidation(GO:0034441) platelet activating factor metabolic process(GO:0046469)
0.0 0.4 GO:0002227 innate immune response in mucosa(GO:0002227)
0.0 0.5 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.0 0.2 GO:0060025 primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185) regulation of synaptic activity(GO:0060025)
0.0 0.5 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.0 1.2 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.0 0.1 GO:0032468 Golgi calcium ion homeostasis(GO:0032468)
0.0 0.1 GO:0051005 negative regulation of lipoprotein lipase activity(GO:0051005)
0.0 0.2 GO:0046598 positive regulation of viral entry into host cell(GO:0046598)
0.0 0.2 GO:0015727 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873)
0.0 0.2 GO:0019695 choline metabolic process(GO:0019695)
0.0 0.3 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.0 0.5 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0 0.1 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.0 0.4 GO:0045332 phospholipid translocation(GO:0045332)
0.0 0.1 GO:0097498 endothelial tube lumen extension(GO:0097498)
0.0 0.1 GO:0046886 positive regulation of hormone biosynthetic process(GO:0046886)
0.0 0.4 GO:0043968 histone H2A acetylation(GO:0043968)
0.0 0.2 GO:0070863 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072) positive regulation of protein exit from endoplasmic reticulum(GO:0070863)
0.0 0.3 GO:0051531 NFAT protein import into nucleus(GO:0051531)
0.0 0.4 GO:0001829 trophectodermal cell differentiation(GO:0001829)
0.0 0.6 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.0 1.8 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0 0.1 GO:0070945 neutrophil mediated killing of gram-negative bacterium(GO:0070945)
0.0 0.3 GO:0007617 mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 4.8 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.4 2.9 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.2 1.0 GO:1990131 Gtr1-Gtr2 GTPase complex(GO:1990131)
0.2 0.9 GO:0031673 H zone(GO:0031673)
0.1 0.6 GO:0045272 plasma membrane respiratory chain complex I(GO:0045272)
0.1 3.6 GO:0005605 basal lamina(GO:0005605)
0.1 0.7 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.1 0.1 GO:0005902 microvillus(GO:0005902)
0.1 0.2 GO:0042585 germinal vesicle(GO:0042585)
0.1 0.5 GO:1990812 growth cone filopodium(GO:1990812)
0.0 0.3 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
0.0 0.4 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 5.2 GO:0030175 filopodium(GO:0030175)
0.0 0.6 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 0.6 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 0.2 GO:0036157 outer dynein arm(GO:0036157)
0.0 0.2 GO:0000801 central element(GO:0000801)
0.0 0.1 GO:0031417 NatC complex(GO:0031417)
0.0 1.0 GO:0048786 presynaptic active zone(GO:0048786)
0.0 0.8 GO:0042629 mast cell granule(GO:0042629)
0.0 1.1 GO:0030286 dynein complex(GO:0030286)
0.0 0.7 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.3 GO:0060077 inhibitory synapse(GO:0060077) clathrin-sculpted gamma-aminobutyric acid transport vesicle(GO:0061200) clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane(GO:0061202)
0.0 0.5 GO:1990023 mitotic spindle midzone(GO:1990023)
0.0 1.8 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 0.2 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 0.4 GO:0016580 Sin3 complex(GO:0016580)
0.0 0.2 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.0 0.2 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.4 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 3.0 GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
0.1 4.8 GO:0002162 dystroglycan binding(GO:0002162)
0.1 0.4 GO:0016899 oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)
0.1 2.0 GO:0048273 mitogen-activated protein kinase p38 binding(GO:0048273)
0.1 0.8 GO:0004918 interleukin-8 receptor activity(GO:0004918)
0.1 4.0 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.1 0.3 GO:0032093 SAM domain binding(GO:0032093)
0.1 0.9 GO:0008046 axon guidance receptor activity(GO:0008046)
0.1 0.8 GO:0015319 sodium:inorganic phosphate symporter activity(GO:0015319)
0.1 0.3 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.1 0.2 GO:0004995 tachykinin receptor activity(GO:0004995)
0.1 0.6 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 1.1 GO:0045504 dynein heavy chain binding(GO:0045504)
0.0 0.6 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 0.9 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 0.4 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
0.0 0.5 GO:0051425 PTB domain binding(GO:0051425)
0.0 0.7 GO:0000150 recombinase activity(GO:0000150)
0.0 1.0 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.1 GO:0046997 oxidoreductase activity, acting on the CH-NH group of donors, flavin as acceptor(GO:0046997)
0.0 0.2 GO:0008479 queuine tRNA-ribosyltransferase activity(GO:0008479)
0.0 0.1 GO:0004874 aryl hydrocarbon receptor activity(GO:0004874)
0.0 0.1 GO:0003870 5-aminolevulinate synthase activity(GO:0003870) N-succinyltransferase activity(GO:0016749)
0.0 0.1 GO:0010465 nerve growth factor receptor activity(GO:0010465)
0.0 1.4 GO:0005109 frizzled binding(GO:0005109)
0.0 0.2 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.0 0.7 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 1.0 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.2 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.0 0.9 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.8 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.0 0.3 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 1.2 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 0.6 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 0.5 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.0 1.2 GO:0050699 WW domain binding(GO:0050699)
0.0 0.1 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.0 0.2 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 0.2 GO:0045499 chemorepellent activity(GO:0045499)
0.0 0.5 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.0 0.6 GO:0000339 RNA cap binding(GO:0000339)
0.0 0.2 GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847)
0.0 0.4 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.1 GO:0032393 MHC class I receptor activity(GO:0032393)
0.0 0.1 GO:0039706 co-receptor binding(GO:0039706)
0.0 0.7 GO:0032452 histone demethylase activity(GO:0032452)
0.0 0.2 GO:0045503 dynein light chain binding(GO:0045503)
0.0 0.3 GO:0001055 RNA polymerase II activity(GO:0001055)
0.0 0.4 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.2 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0 0.2 GO:0003680 AT DNA binding(GO:0003680)
0.0 1.3 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 2.5 GO:0008083 growth factor activity(GO:0008083)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.0 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 2.9 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.0 4.8 PID LKB1 PATHWAY LKB1 signaling events
0.0 0.4 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.0 2.6 ST JNK MAPK PATHWAY JNK MAPK Pathway
0.0 0.8 ST GRANULE CELL SURVIVAL PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0 0.6 PID CONE PATHWAY Visual signal transduction: Cones
0.0 1.1 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 1.2 PID MTOR 4PATHWAY mTOR signaling pathway
0.0 0.8 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.0 1.2 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 0.8 PID PS1 PATHWAY Presenilin action in Notch and Wnt signaling
0.0 1.4 PID P73PATHWAY p73 transcription factor network
0.0 0.9 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.0 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.0 1.0 REACTOME ACTIVATED POINT MUTANTS OF FGFR2 Genes involved in Activated point mutants of FGFR2
0.0 2.5 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 1.3 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.0 0.6 REACTOME G PROTEIN ACTIVATION Genes involved in G-protein activation
0.0 0.7 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 2.5 REACTOME G1 PHASE Genes involved in G1 Phase
0.0 0.9 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 4.0 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.5 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 0.8 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.0 0.6 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.4 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.2 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 1.0 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 1.4 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 0.2 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.0 0.8 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 1.8 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 0.3 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling