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SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for NKX6-3

Z-value: 0.25

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Transcription factors associated with NKX6-3

Gene Symbol Gene ID Gene Info
NKX6-3
ENSG00000165066.11 NK6 homeobox 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NKX6-3hg19_v2_chr8_-_41508855_415088550.058.5e-01Click!

Activity profile of NKX6-3 motif

Sorted Z-values of NKX6-3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr5_-_58295712 0.52 ENST00000317118.8
PDE4D
phosphodiesterase 4D, cAMP-specific
chr14_+_67831576 0.52 ENST00000555876.1
EIF2S1
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
chr2_-_44550441 0.41 ENST00000420756.1
ENST00000444696.1
PREPL
prolyl endopeptidase-like
chr17_-_64225508 0.41 ENST00000205948.6
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr1_+_66820058 0.39 ENST00000480109.2
PDE4B
phosphodiesterase 4B, cAMP-specific
chr18_+_32558380 0.39 ENST00000588349.2
MAPRE2
microtubule-associated protein, RP/EB family, member 2
chr10_-_27529486 0.34 ENST00000375888.1
ACBD5
acyl-CoA binding domain containing 5
chr12_-_52761262 0.29 ENST00000257901.3
KRT85
keratin 85
chr11_-_115127611 0.26 ENST00000545094.1
CADM1
cell adhesion molecule 1
chr18_+_32558208 0.25 ENST00000436190.2
MAPRE2
microtubule-associated protein, RP/EB family, member 2
chr14_-_51027838 0.23 ENST00000555216.1
MAP4K5
mitogen-activated protein kinase kinase kinase kinase 5
chr15_+_90735145 0.21 ENST00000559792.1
SEMA4B
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B
chr3_+_138340067 0.20 ENST00000479848.1
FAIM
Fas apoptotic inhibitory molecule
chr5_-_142780280 0.20 ENST00000424646.2
NR3C1
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr17_+_4692230 0.18 ENST00000331264.7
GLTPD2
glycolipid transfer protein domain containing 2
chr20_-_33735070 0.17 ENST00000374491.3
ENST00000542871.1
ENST00000374492.3
EDEM2
ER degradation enhancer, mannosidase alpha-like 2
chr1_-_232651312 0.12 ENST00000262861.4
SIPA1L2
signal-induced proliferation-associated 1 like 2
chrX_+_150565038 0.11 ENST00000370361.1
VMA21
VMA21 vacuolar H+-ATPase homolog (S. cerevisiae)
chr3_-_191000172 0.11 ENST00000427544.2
UTS2B
urotensin 2B
chr13_+_53602894 0.08 ENST00000219022.2
OLFM4
olfactomedin 4
chr17_-_38956205 0.08 ENST00000306658.7
KRT28
keratin 28
chr3_+_138340049 0.07 ENST00000464668.1
FAIM
Fas apoptotic inhibitory molecule
chr14_+_88852059 0.06 ENST00000045347.7
SPATA7
spermatogenesis associated 7
chr14_+_88851874 0.06 ENST00000393545.4
ENST00000356583.5
ENST00000555401.1
ENST00000553885.1
SPATA7
spermatogenesis associated 7
chrX_+_47696337 0.05 ENST00000334937.4
ENST00000376950.4
ZNF81
zinc finger protein 81
chr8_+_77593474 0.05 ENST00000455469.2
ENST00000050961.6
ZFHX4
zinc finger homeobox 4
chr2_+_234826016 0.05 ENST00000324695.4
ENST00000433712.2
TRPM8
transient receptor potential cation channel, subfamily M, member 8
chr19_+_4402659 0.05 ENST00000301280.5
ENST00000585854.1
CHAF1A
chromatin assembly factor 1, subunit A (p150)
chr15_+_48483736 0.05 ENST00000417307.2
ENST00000559641.1
CTXN2
SLC12A1
cortexin 2
solute carrier family 12 (sodium/potassium/chloride transporter), member 1
chr8_+_92261516 0.04 ENST00000276609.3
ENST00000309536.2
SLC26A7
solute carrier family 26 (anion exchanger), member 7
chr11_+_22689648 0.03 ENST00000278187.3
GAS2
growth arrest-specific 2
chr4_-_123542224 0.03 ENST00000264497.3
IL21
interleukin 21
chrX_-_130423200 0.03 ENST00000361420.3
IGSF1
immunoglobulin superfamily, member 1
chr16_-_14109841 0.03 ENST00000576797.1
ENST00000575424.1
CTD-2135D7.5
CTD-2135D7.5
chr7_+_138145076 0.02 ENST00000343526.4
TRIM24
tripartite motif containing 24
chr8_+_77593448 0.02 ENST00000521891.2
ZFHX4
zinc finger homeobox 4
chr21_-_39705323 0.02 ENST00000436845.1
AP001422.3
AP001422.3
chr15_+_48051920 0.01 ENST00000559196.1
SEMA6D
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
chr6_-_9933500 0.01 ENST00000492169.1
OFCC1
orofacial cleft 1 candidate 1
chr16_-_67517716 0.00 ENST00000290953.2
AGRP
agouti related protein homolog (mouse)
chr9_+_125133467 0.00 ENST00000426608.1
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chrX_-_110655306 0.00 ENST00000371993.2
DCX
doublecortin

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX6-3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:1990737 response to manganese-induced endoplasmic reticulum stress(GO:1990737)
0.1 0.9 GO:1901078 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 0.3 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.0 0.3 GO:0030242 pexophagy(GO:0030242)
0.0 0.2 GO:0036509 trimming of terminal mannose on B branch(GO:0036509) trimming of first mannose on A branch(GO:0036511) trimming of second mannose on A branch(GO:0036512)
0.0 0.4 GO:0034392 negative regulation of smooth muscle cell apoptotic process(GO:0034392)
0.0 0.2 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0043614 multi-eIF complex(GO:0043614) translation preinitiation complex(GO:0070993) glial limiting end-foot(GO:0097451)
0.0 0.4 GO:0031089 platelet dense granule lumen(GO:0031089)
0.0 0.9 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.6 GO:0035371 microtubule plus-end(GO:0035371)
0.0 0.0 GO:0033186 CAF-1 complex(GO:0033186)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.0 0.5 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)
0.0 0.2 GO:0038051 glucocorticoid receptor activity(GO:0004883) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.0 0.0 GO:0008511 sodium:potassium:chloride symporter activity(GO:0008511)
0.0 0.4 GO:0070008 serine-type exopeptidase activity(GO:0070008)
0.0 0.2 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0 0.4 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.3 GO:0000062 fatty-acyl-CoA binding(GO:0000062)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.9 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 0.5 REACTOME PERK REGULATED GENE EXPRESSION Genes involved in PERK regulated gene expression