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SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for NOTO_VSX2_DLX2_DLX6_NKX6-1
Z-value: 1.14
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Transcription factors associated with NOTO_VSX2_DLX2_DLX6_NKX6-1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000214513.3 | notochord homeobox | |
| ENSG00000119614.2 | visual system homeobox 2 | |
| ENSG00000115844.6 | distal-less homeobox 2 | |
| ENSG00000006377.9 | distal-less homeobox 6 | |
| ENSG00000163623.5 | NK6 homeobox 1 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NKX6-1 | hg19_v2_chr4_-_85419603_85419603 | -0.54 | 1.5e-02 | Click! |
| DLX6 | hg19_v2_chr7_+_96634850_96634874 | 0.45 | 4.7e-02 | Click! |
| NOTO | hg19_v2_chr2_+_73429386_73429386 | 0.23 | 3.2e-01 | Click! |
| DLX2 | hg19_v2_chr2_-_172967621_172967637 | -0.23 | 3.3e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr12_-_28122980 Show fit | 6.36 |
ENST00000395868.3
ENST00000534890.1 |
parathyroid hormone-like hormone |
|
| chr12_-_28123206 Show fit | 5.96 |
ENST00000542963.1
ENST00000535992.1 |
parathyroid hormone-like hormone |
|
| chr11_+_35222629 Show fit | 4.28 |
ENST00000526553.1
|
CD44 molecule (Indian blood group) |
|
| chr5_+_31193847 Show fit | 3.77 |
ENST00000514738.1
ENST00000265071.2 |
cadherin 6, type 2, K-cadherin (fetal kidney) |
|
| chr6_-_32157947 Show fit | 3.45 |
ENST00000375050.4
|
pre-B-cell leukemia homeobox 2 |
|
| chr14_-_36988882 Show fit | 3.16 |
ENST00000498187.2
|
NK2 homeobox 1 |
|
| chr3_-_151034734 Show fit | 2.86 |
ENST00000260843.4
|
G protein-coupled receptor 87 |
|
| chr11_-_129062093 Show fit | 2.81 |
ENST00000310343.9
|
Rho GTPase activating protein 32 |
|
| chr3_+_111717511 Show fit | 2.76 |
ENST00000478951.1
ENST00000393917.2 |
transgelin 3 |
|
| chr3_+_111718036 Show fit | 2.53 |
ENST00000455401.2
|
transgelin 3 |
Network of associatons between targets according to the STRING database.
First level regulatory network of NOTO_VSX2_DLX2_DLX6_NKX6-1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 14.3 | GO:0032331 | negative regulation of chondrocyte differentiation(GO:0032331) |
| 0.1 | 5.0 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.5 | 4.6 | GO:1900623 | regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625) |
| 0.0 | 3.7 | GO:0007219 | Notch signaling pathway(GO:0007219) |
| 0.0 | 3.6 | GO:0001578 | microtubule bundle formation(GO:0001578) |
| 0.1 | 3.4 | GO:0007274 | neuromuscular synaptic transmission(GO:0007274) |
| 1.1 | 3.3 | GO:0070563 | negative regulation of vitamin D receptor signaling pathway(GO:0070563) |
| 0.3 | 3.3 | GO:0021759 | globus pallidus development(GO:0021759) |
| 0.1 | 2.9 | GO:0035589 | G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589) |
| 0.0 | 2.9 | GO:0061001 | regulation of dendritic spine morphogenesis(GO:0061001) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 8.4 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.0 | 7.1 | GO:0043197 | dendritic spine(GO:0043197) |
| 0.6 | 4.6 | GO:0035692 | macrophage migration inhibitory factor receptor complex(GO:0035692) |
| 0.1 | 4.1 | GO:0030964 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.4 | 3.2 | GO:0097442 | CA3 pyramidal cell dendrite(GO:0097442) |
| 0.0 | 2.7 | GO:0031594 | neuromuscular junction(GO:0031594) |
| 0.1 | 2.4 | GO:0032839 | dendrite cytoplasm(GO:0032839) |
| 0.0 | 2.1 | GO:0042383 | sarcolemma(GO:0042383) |
| 0.0 | 1.8 | GO:0008023 | transcription elongation factor complex(GO:0008023) |
| 0.1 | 1.6 | GO:0071953 | elastic fiber(GO:0071953) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 14.5 | GO:0051428 | peptide hormone receptor binding(GO:0051428) |
| 0.0 | 11.1 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.0 | 6.4 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.1 | 5.0 | GO:0008137 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.1 | 4.4 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.0 | 4.4 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.1 | 3.3 | GO:0001161 | intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213) |
| 0.1 | 2.9 | GO:0045028 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
| 0.1 | 2.2 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
| 0.0 | 2.1 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 14.4 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.0 | 5.0 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.0 | 4.7 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 4.6 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.1 | 4.5 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 3.3 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.0 | 2.5 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.0 | 1.9 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.0 | 1.8 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.0 | 1.6 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 13.8 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.2 | 4.6 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.0 | 2.8 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.1 | 2.4 | REACTOME ERKS ARE INACTIVATED | Genes involved in ERKs are inactivated |
| 0.0 | 2.2 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.0 | 1.5 | REACTOME INTEGRATION OF ENERGY METABOLISM | Genes involved in Integration of energy metabolism |
| 0.1 | 1.3 | REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.0 | 1.0 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.0 | 0.9 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.0 | 0.9 | REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT | Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT) |