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SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for NOTO_VSX2_DLX2_DLX6_NKX6-1

Z-value: 1.14

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Transcription factors associated with NOTO_VSX2_DLX2_DLX6_NKX6-1

Gene Symbol Gene ID Gene Info
NOTO
ENSG00000214513.3 notochord homeobox
VSX2
ENSG00000119614.2 visual system homeobox 2
DLX2
ENSG00000115844.6 distal-less homeobox 2
DLX6
ENSG00000006377.9 distal-less homeobox 6
NKX6-1
ENSG00000163623.5 NK6 homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NKX6-1hg19_v2_chr4_-_85419603_85419603-0.541.5e-02Click!
DLX6hg19_v2_chr7_+_96634850_966348740.454.7e-02Click!
NOTOhg19_v2_chr2_+_73429386_734293860.233.2e-01Click!
DLX2hg19_v2_chr2_-_172967621_172967637-0.233.3e-01Click!

Activity profile of NOTO_VSX2_DLX2_DLX6_NKX6-1 motif

Sorted Z-values of NOTO_VSX2_DLX2_DLX6_NKX6-1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr12_-_28122980 6.36 ENST00000395868.3
ENST00000534890.1
PTHLH
parathyroid hormone-like hormone
chr12_-_28123206 5.96 ENST00000542963.1
ENST00000535992.1
PTHLH
parathyroid hormone-like hormone
chr11_+_35222629 4.28 ENST00000526553.1
CD44
CD44 molecule (Indian blood group)
chr5_+_31193847 3.77 ENST00000514738.1
ENST00000265071.2
CDH6
cadherin 6, type 2, K-cadherin (fetal kidney)
chr6_-_32157947 3.45 ENST00000375050.4
PBX2
pre-B-cell leukemia homeobox 2
chr14_-_36988882 3.16 ENST00000498187.2
NKX2-1
NK2 homeobox 1
chr3_-_151034734 2.86 ENST00000260843.4
GPR87
G protein-coupled receptor 87
chr11_-_129062093 2.81 ENST00000310343.9
ARHGAP32
Rho GTPase activating protein 32
chr3_+_111717511 2.76 ENST00000478951.1
ENST00000393917.2
TAGLN3
transgelin 3
chr3_+_111718036 2.53 ENST00000455401.2
TAGLN3
transgelin 3
chr5_+_66300446 2.47 ENST00000261569.7
MAST4
microtubule associated serine/threonine kinase family member 4
chr5_+_166711804 2.35 ENST00000518659.1
ENST00000545108.1
TENM2
teneurin transmembrane protein 2
chr5_+_66300464 2.33 ENST00000436277.1
MAST4
microtubule associated serine/threonine kinase family member 4
chr1_+_68150744 2.31 ENST00000370986.4
ENST00000370985.3
GADD45A
growth arrest and DNA-damage-inducible, alpha
chr5_-_24645078 2.20 ENST00000264463.4
CDH10
cadherin 10, type 2 (T2-cadherin)
chr3_+_111717600 2.11 ENST00000273368.4
TAGLN3
transgelin 3
chr18_+_32173276 2.09 ENST00000591816.1
ENST00000588125.1
ENST00000598334.1
ENST00000588684.1
ENST00000554864.3
ENST00000399121.5
ENST00000595022.1
ENST00000269190.7
ENST00000399097.3
DTNA
dystrobrevin, alpha
chr4_-_74486217 2.08 ENST00000335049.5
ENST00000307439.5
RASSF6
Ras association (RalGDS/AF-6) domain family member 6
chr14_+_72052983 2.02 ENST00000358550.2
SIPA1L1
signal-induced proliferation-associated 1 like 1
chr7_-_27169801 1.94 ENST00000511914.1
HOXA4
homeobox A4
chr6_+_130339710 1.77 ENST00000526087.1
ENST00000533560.1
ENST00000361794.2
L3MBTL3
l(3)mbt-like 3 (Drosophila)
chr8_-_49833978 1.66 ENST00000020945.1
SNAI2
snail family zinc finger 2
chr11_+_65554493 1.65 ENST00000335987.3
OVOL1
ovo-like zinc finger 1
chr12_-_89746173 1.63 ENST00000308385.6
DUSP6
dual specificity phosphatase 6
chr8_-_49834299 1.61 ENST00000396822.1
SNAI2
snail family zinc finger 2
chr1_-_68698222 1.56 ENST00000370976.3
ENST00000354777.2
ENST00000262348.4
ENST00000540432.1
WLS
wntless Wnt ligand secretion mediator
chr8_-_128231299 1.50 ENST00000500112.1
CCAT1
colon cancer associated transcript 1 (non-protein coding)
chr13_-_86373536 1.49 ENST00000400286.2
SLITRK6
SLIT and NTRK-like family, member 6
chrM_+_10053 1.44 ENST00000361227.2
MT-ND3
mitochondrially encoded NADH dehydrogenase 3
chr13_-_36050819 1.44 ENST00000379919.4
MAB21L1
mab-21-like 1 (C. elegans)
chr2_+_210444142 1.42 ENST00000360351.4
ENST00000361559.4
MAP2
microtubule-associated protein 2
chr8_-_42234745 1.42 ENST00000220812.2
DKK4
dickkopf WNT signaling pathway inhibitor 4
chr2_+_17997763 1.42 ENST00000281047.3
MSGN1
mesogenin 1
chr5_-_126409159 1.39 ENST00000607731.1
ENST00000535381.1
ENST00000296662.5
ENST00000509733.3
C5orf63
chromosome 5 open reading frame 63
chr18_+_61445007 1.37 ENST00000447428.1
ENST00000546027.1
SERPINB7
serpin peptidase inhibitor, clade B (ovalbumin), member 7
chr13_-_46716969 1.34 ENST00000435666.2
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr3_+_111718173 1.34 ENST00000494932.1
TAGLN3
transgelin 3
chr4_-_74486347 1.33 ENST00000342081.3
RASSF6
Ras association (RalGDS/AF-6) domain family member 6
chr10_+_24755416 1.33 ENST00000396446.1
ENST00000396445.1
ENST00000376451.2
KIAA1217
KIAA1217
chr1_-_152131703 1.32 ENST00000316073.3
RPTN
repetin
chr4_+_69313145 1.28 ENST00000305363.4
TMPRSS11E
transmembrane protease, serine 11E
chr5_-_95297678 1.27 ENST00000237853.4
ELL2
elongation factor, RNA polymerase II, 2
chr19_+_13049413 1.26 ENST00000316448.5
ENST00000588454.1
CALR
calreticulin
chr5_-_141249154 1.26 ENST00000357517.5
ENST00000536585.1
PCDH1
protocadherin 1
chr17_-_39093672 1.25 ENST00000209718.3
ENST00000436344.3
ENST00000485751.1
KRT23
keratin 23 (histone deacetylase inducible)
chr4_-_36245561 1.24 ENST00000506189.1
ARAP2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chrM_+_7586 1.23 ENST00000361739.1
MT-CO2
mitochondrially encoded cytochrome c oxidase II
chr17_+_59489112 1.22 ENST00000335108.2
C17orf82
chromosome 17 open reading frame 82
chr8_-_139926236 1.20 ENST00000303045.6
ENST00000435777.1
COL22A1
collagen, type XXII, alpha 1
chr5_-_141030943 1.20 ENST00000522783.1
ENST00000519800.1
ENST00000435817.2
FCHSD1
FCH and double SH3 domains 1
chr6_-_31107127 1.18 ENST00000259845.4
PSORS1C2
psoriasis susceptibility 1 candidate 2
chr12_-_28125638 1.18 ENST00000545234.1
PTHLH
parathyroid hormone-like hormone
chr19_-_51522955 1.16 ENST00000358789.3
KLK10
kallikrein-related peptidase 10
chr2_-_214016314 1.14 ENST00000434687.1
ENST00000374319.4
IKZF2
IKAROS family zinc finger 2 (Helios)
chr2_+_210443993 1.13 ENST00000392193.1
MAP2
microtubule-associated protein 2
chr13_-_38172863 1.13 ENST00000541481.1
ENST00000379743.4
ENST00000379742.4
ENST00000379749.4
ENST00000541179.1
ENST00000379747.4
POSTN
periostin, osteoblast specific factor
chr1_-_152386732 1.12 ENST00000271835.3
CRNN
cornulin
chr7_-_92777606 1.11 ENST00000437805.1
ENST00000446959.1
ENST00000439952.1
ENST00000414791.1
ENST00000446033.1
ENST00000411955.1
ENST00000318238.4
SAMD9L
sterile alpha motif domain containing 9-like
chr4_+_3388057 1.07 ENST00000538395.1
RGS12
regulator of G-protein signaling 12
chr7_+_23286182 1.07 ENST00000258733.4
ENST00000381990.2
ENST00000409458.3
ENST00000539136.1
ENST00000453162.2
GPNMB
glycoprotein (transmembrane) nmb
chr4_+_169013666 1.06 ENST00000359299.3
ANXA10
annexin A10
chr15_+_49715449 1.03 ENST00000560979.1
FGF7
fibroblast growth factor 7
chr17_-_7167279 1.02 ENST00000571932.2
CLDN7
claudin 7
chr16_-_4852915 0.99 ENST00000322048.7
ROGDI
rogdi homolog (Drosophila)
chrM_+_10758 0.99 ENST00000361381.2
MT-ND4
mitochondrially encoded NADH dehydrogenase 4
chr1_+_160370344 0.99 ENST00000368061.2
VANGL2
VANGL planar cell polarity protein 2
chr8_-_1922789 0.96 ENST00000521498.1
RP11-439C15.4
RP11-439C15.4
chr18_+_61445205 0.96 ENST00000431370.1
SERPINB7
serpin peptidase inhibitor, clade B (ovalbumin), member 7
chr1_+_28586006 0.95 ENST00000253063.3
SESN2
sestrin 2
chr20_-_45980621 0.94 ENST00000446894.1
ZMYND8
zinc finger, MYND-type containing 8
chr3_-_74570291 0.93 ENST00000263665.6
CNTN3
contactin 3 (plasmacytoma associated)
chr11_+_34663913 0.91 ENST00000532302.1
EHF
ets homologous factor
chr12_-_28124903 0.91 ENST00000395872.1
ENST00000354417.3
ENST00000201015.4
PTHLH
parathyroid hormone-like hormone
chr4_-_74486109 0.90 ENST00000395777.2
RASSF6
Ras association (RalGDS/AF-6) domain family member 6
chr19_-_51523412 0.88 ENST00000391805.1
ENST00000599077.1
KLK10
kallikrein-related peptidase 10
chr16_-_30102547 0.88 ENST00000279386.2
TBX6
T-box 6
chrM_-_14670 0.88 ENST00000361681.2
MT-ND6
mitochondrially encoded NADH dehydrogenase 6
chr4_+_71384257 0.87 ENST00000339336.4
AMTN
amelotin
chr16_+_69345243 0.87 ENST00000254950.11
VPS4A
vacuolar protein sorting 4 homolog A (S. cerevisiae)
chr11_+_34664014 0.86 ENST00000527935.1
EHF
ets homologous factor
chr2_+_171034646 0.85 ENST00000409044.3
ENST00000408978.4
MYO3B
myosin IIIB
chr14_-_38064198 0.84 ENST00000250448.2
FOXA1
forkhead box A1
chr14_-_92413727 0.84 ENST00000267620.10
FBLN5
fibulin 5
chr2_+_66918558 0.84 ENST00000435389.1
ENST00000428590.1
ENST00000412944.1
AC007392.3
AC007392.3
chr16_+_22501658 0.84 ENST00000415833.2
NPIPB5
nuclear pore complex interacting protein family, member B5
chr12_-_30887948 0.83 ENST00000433722.2
CAPRIN2
caprin family member 2
chr6_-_39693111 0.81 ENST00000373215.3
ENST00000538893.1
ENST00000287152.7
ENST00000373216.3
KIF6
kinesin family member 6
chr8_-_72268721 0.81 ENST00000419131.1
ENST00000388743.2
EYA1
eyes absent homolog 1 (Drosophila)
chr9_-_3469181 0.81 ENST00000366116.2
AL365202.1
Uncharacterized protein
chr19_-_7698599 0.79 ENST00000311069.5
PCP2
Purkinje cell protein 2
chr14_-_69261310 0.77 ENST00000336440.3
ZFP36L1
ZFP36 ring finger protein-like 1
chr7_-_73038822 0.77 ENST00000414749.2
ENST00000429400.2
ENST00000434326.1
MLXIPL
MLX interacting protein-like
chr12_-_89746264 0.75 ENST00000548755.1
DUSP6
dual specificity phosphatase 6
chr19_-_51523275 0.75 ENST00000309958.3
KLK10
kallikrein-related peptidase 10
chr3_-_12587055 0.70 ENST00000564146.3
C3orf83
chromosome 3 open reading frame 83
chrX_+_43515467 0.69 ENST00000338702.3
ENST00000542639.1
MAOA
monoamine oxidase A
chr2_+_210444298 0.68 ENST00000445941.1
MAP2
microtubule-associated protein 2
chr19_-_7968427 0.67 ENST00000539278.1
AC010336.1
Uncharacterized protein
chr19_-_36304201 0.66 ENST00000301175.3
PRODH2
proline dehydrogenase (oxidase) 2
chr4_+_71384300 0.64 ENST00000504451.1
AMTN
amelotin
chr14_-_73360796 0.64 ENST00000556509.1
ENST00000541685.1
ENST00000546183.1
DPF3
D4, zinc and double PHD fingers, family 3
chr11_-_33913708 0.63 ENST00000257818.2
LMO2
LIM domain only 2 (rhombotin-like 1)
chr7_-_73038867 0.63 ENST00000313375.3
ENST00000354613.1
ENST00000395189.1
ENST00000453275.1
MLXIPL
MLX interacting protein-like
chr12_+_4385230 0.63 ENST00000536537.1
CCND2
cyclin D2
chr11_+_128563652 0.63 ENST00000527786.2
FLI1
Fli-1 proto-oncogene, ETS transcription factor
chr8_-_37351344 0.63 ENST00000520422.1
RP11-150O12.1
RP11-150O12.1
chr4_-_186696425 0.63 ENST00000430503.1
ENST00000319454.6
ENST00000450341.1
SORBS2
sorbin and SH3 domain containing 2
chrM_+_3299 0.62 ENST00000361390.2
MT-ND1
mitochondrially encoded NADH dehydrogenase 1
chr1_-_9953295 0.61 ENST00000377258.1
CTNNBIP1
catenin, beta interacting protein 1
chr13_-_30683005 0.60 ENST00000413591.1
ENST00000432770.1
LINC00365
long intergenic non-protein coding RNA 365
chr1_+_61547894 0.60 ENST00000403491.3
NFIA
nuclear factor I/A
chr11_-_117747607 0.60 ENST00000540359.1
ENST00000539526.1
FXYD6
FXYD domain containing ion transport regulator 6
chr1_-_68698197 0.59 ENST00000370973.2
ENST00000370971.1
WLS
wntless Wnt ligand secretion mediator
chr12_-_16761007 0.59 ENST00000354662.1
ENST00000441439.2
LMO3
LIM domain only 3 (rhombotin-like 2)
chr12_-_50616382 0.58 ENST00000552783.1
LIMA1
LIM domain and actin binding 1
chr4_-_186696561 0.58 ENST00000445115.1
ENST00000451701.1
ENST00000457247.1
ENST00000435480.1
ENST00000425679.1
ENST00000457934.1
SORBS2
sorbin and SH3 domain containing 2
chrM_+_8527 0.57 ENST00000361899.2
MT-ATP6
mitochondrially encoded ATP synthase 6
chr2_+_171571827 0.57 ENST00000375281.3
SP5
Sp5 transcription factor
chr4_+_71457970 0.57 ENST00000322937.6
AMBN
ameloblastin (enamel matrix protein)
chr11_-_16419067 0.57 ENST00000533411.1
SOX6
SRY (sex determining region Y)-box 6
chr16_+_8768422 0.56 ENST00000268251.8
ENST00000564714.1
ABAT
4-aminobutyrate aminotransferase
chr12_-_94673956 0.56 ENST00000551941.1
RP11-1105G2.3
Uncharacterized protein
chr8_-_109799793 0.56 ENST00000297459.3
TMEM74
transmembrane protein 74
chr19_-_56110859 0.56 ENST00000221665.3
ENST00000592585.1
FIZ1
FLT3-interacting zinc finger 1
chr20_+_42136308 0.56 ENST00000434666.1
ENST00000427442.2
ENST00000439769.1
ENST00000418998.1
L3MBTL1
l(3)mbt-like 1 (Drosophila)
chr12_-_15114603 0.54 ENST00000228945.4
ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chr6_-_100912785 0.54 ENST00000369208.3
SIM1
single-minded family bHLH transcription factor 1
chr2_-_182545603 0.53 ENST00000295108.3
NEUROD1
neuronal differentiation 1
chr19_-_7697857 0.53 ENST00000598935.1
PCP2
Purkinje cell protein 2
chr5_-_115890554 0.53 ENST00000509665.1
SEMA6A
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
chr17_-_38928414 0.53 ENST00000335552.4
KRT26
keratin 26
chr5_-_95297534 0.52 ENST00000513343.1
ENST00000431061.2
ELL2
elongation factor, RNA polymerase II, 2
chr5_+_36606700 0.52 ENST00000416645.2
SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr11_+_124735282 0.52 ENST00000397801.1
ROBO3
roundabout, axon guidance receptor, homolog 3 (Drosophila)
chr4_+_155484155 0.52 ENST00000509493.1
FGB
fibrinogen beta chain
chr3_-_69402828 0.51 ENST00000460709.1
FRMD4B
FERM domain containing 4B
chr8_-_37351424 0.51 ENST00000522718.1
RP11-150O12.1
RP11-150O12.1
chr2_-_80531399 0.51 ENST00000409148.1
ENST00000415098.1
ENST00000452811.1
LRRTM1
leucine rich repeat transmembrane neuronal 1
chrM_+_14741 0.50 ENST00000361789.2
MT-CYB
mitochondrially encoded cytochrome b
chr8_-_133637624 0.49 ENST00000522789.1
LRRC6
leucine rich repeat containing 6
chr14_+_61654271 0.49 ENST00000555185.1
ENST00000557294.1
ENST00000556778.1
PRKCH
protein kinase C, eta
chr18_-_47792851 0.49 ENST00000398545.4
CCDC11
coiled-coil domain containing 11
chr19_-_14064114 0.48 ENST00000585607.1
ENST00000538517.2
ENST00000587458.1
ENST00000538371.2
PODNL1
podocan-like 1
chr8_-_116673894 0.48 ENST00000395713.2
TRPS1
trichorhinophalangeal syndrome I
chr18_-_68004529 0.48 ENST00000578633.1
RP11-484N16.1
RP11-484N16.1
chr9_+_2159850 0.48 ENST00000416751.1
SMARCA2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr4_-_41884620 0.47 ENST00000504870.1
LINC00682
long intergenic non-protein coding RNA 682
chr6_-_111888474 0.46 ENST00000368735.1
TRAF3IP2
TRAF3 interacting protein 2
chr6_-_36515177 0.46 ENST00000229812.7
STK38
serine/threonine kinase 38
chr17_+_72931876 0.46 ENST00000328801.4
OTOP3
otopetrin 3
chr15_+_44092784 0.45 ENST00000458412.1
HYPK
huntingtin interacting protein K
chr12_-_16761117 0.45 ENST00000538051.1
LMO3
LIM domain only 3 (rhombotin-like 2)
chr6_+_55192267 0.45 ENST00000340465.2
GFRAL
GDNF family receptor alpha like
chr4_+_71458012 0.44 ENST00000449493.2
AMBN
ameloblastin (enamel matrix protein)
chr5_-_88119580 0.44 ENST00000539796.1
MEF2C
myocyte enhancer factor 2C
chrX_+_134654540 0.44 ENST00000370752.4
DDX26B
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B
chr9_+_135457530 0.43 ENST00000263610.2
BARHL1
BarH-like homeobox 1
chr19_-_12889226 0.43 ENST00000589400.1
ENST00000590839.1
ENST00000592079.1
HOOK2
hook microtubule-tethering protein 2
chr4_-_89205705 0.43 ENST00000295908.7
ENST00000510548.2
ENST00000508256.1
PPM1K
protein phosphatase, Mg2+/Mn2+ dependent, 1K
chr8_+_38831683 0.43 ENST00000302495.4
HTRA4
HtrA serine peptidase 4
chr11_+_71900703 0.43 ENST00000393681.2
FOLR1
folate receptor 1 (adult)
chr12_-_15114191 0.43 ENST00000541380.1
ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chr5_+_69321074 0.42 ENST00000380751.5
ENST00000380750.3
ENST00000503931.1
ENST00000506542.1
SERF1B
small EDRK-rich factor 1B (centromeric)
chr11_+_12302492 0.42 ENST00000533534.1
MICALCL
MICAL C-terminal like
chr3_+_121774202 0.42 ENST00000469710.1
ENST00000493101.1
ENST00000330540.2
ENST00000264468.5
CD86
CD86 molecule
chr11_+_71900572 0.42 ENST00000312293.4
FOLR1
folate receptor 1 (adult)
chr5_-_56778635 0.42 ENST00000423391.1
ACTBL2
actin, beta-like 2
chrX_+_105937068 0.42 ENST00000324342.3
RNF128
ring finger protein 128, E3 ubiquitin protein ligase
chr4_-_57547870 0.41 ENST00000381260.3
ENST00000420433.1
ENST00000554144.1
ENST00000557328.1
HOPX
HOP homeobox
chr4_+_155484103 0.41 ENST00000302068.4
FGB
fibrinogen beta chain
chr5_-_137475071 0.41 ENST00000265191.2
NME5
NME/NM23 family member 5
chr12_-_15114658 0.41 ENST00000542276.1
ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chr2_-_87248975 0.40 ENST00000409310.2
ENST00000355705.3
PLGLB1
plasminogen-like B1
chr4_-_87770416 0.40 ENST00000273905.6
SLC10A6
solute carrier family 10 (sodium/bile acid cotransporter), member 6
chr7_+_73442422 0.40 ENST00000358929.4
ENST00000431562.1
ENST00000320492.7
ENST00000438906.1
ELN
elastin
chr15_+_96869165 0.40 ENST00000421109.2
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr15_-_55562451 0.40 ENST00000568803.1
RAB27A
RAB27A, member RAS oncogene family
chrX_+_105936982 0.40 ENST00000418562.1
RNF128
ring finger protein 128, E3 ubiquitin protein ligase
chr5_-_1882858 0.40 ENST00000511126.1
ENST00000231357.2
IRX4
iroquois homeobox 4
chr20_-_50722183 0.40 ENST00000371523.4
ZFP64
ZFP64 zinc finger protein
chr12_-_15114492 0.39 ENST00000541546.1
ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chr2_-_216003127 0.39 ENST00000412081.1
ENST00000272895.7
ABCA12
ATP-binding cassette, sub-family A (ABC1), member 12
chrM_+_10464 0.39 ENST00000361335.1
MT-ND4L
mitochondrially encoded NADH dehydrogenase 4L
chr20_-_50418947 0.39 ENST00000371539.3
SALL4
spalt-like transcription factor 4
chr17_-_38859996 0.39 ENST00000264651.2
KRT24
keratin 24
chr19_+_50016610 0.38 ENST00000596975.1
FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr18_-_53089723 0.38 ENST00000561992.1
ENST00000562512.2
TCF4
transcription factor 4
chr1_+_160160283 0.38 ENST00000368079.3
CASQ1
calsequestrin 1 (fast-twitch, skeletal muscle)
chr2_-_50201327 0.38 ENST00000412315.1
NRXN1
neurexin 1
chr21_+_17442799 0.38 ENST00000602580.1
ENST00000458468.1
ENST00000602935.1
LINC00478
long intergenic non-protein coding RNA 478
chrM_+_9207 0.38 ENST00000362079.2
MT-CO3
mitochondrially encoded cytochrome c oxidase III
chr4_-_140223614 0.38 ENST00000394223.1
NDUFC1
NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa
chr2_+_158114051 0.38 ENST00000259056.4
GALNT5
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)
chr10_+_24544249 0.37 ENST00000430453.2
KIAA1217
KIAA1217
chr8_+_105235572 0.37 ENST00000523362.1
RIMS2
regulating synaptic membrane exocytosis 2
chr4_-_184243561 0.37 ENST00000514470.1
ENST00000541814.1
CLDN24
claudin 24
chr14_+_23790655 0.37 ENST00000397276.2
PABPN1
poly(A) binding protein, nuclear 1
chr11_-_94965667 0.37 ENST00000542176.1
ENST00000278499.2
SESN3
sestrin 3
chr4_-_140544386 0.37 ENST00000561977.1
RP11-308D13.3
RP11-308D13.3
chr21_-_31538971 0.36 ENST00000286808.3
CLDN17
claudin 17

Network of associatons between targets according to the STRING database.

First level regulatory network of NOTO_VSX2_DLX2_DLX6_NKX6-1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.3 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
0.6 1.7 GO:0070175 positive regulation of enamel mineralization(GO:0070175)
0.5 2.1 GO:0061357 positive regulation of Wnt protein secretion(GO:0061357)
0.5 4.6 GO:1900623 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.5 2.4 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
0.5 2.3 GO:0090362 positive regulation of platelet-derived growth factor production(GO:0090362)
0.4 1.7 GO:1901994 negative regulation of meiotic cell cycle phase transition(GO:1901994)
0.4 14.3 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)
0.3 1.0 GO:0060489 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.3 1.5 GO:0060005 vestibular reflex(GO:0060005)
0.3 0.9 GO:1903774 positive regulation of viral budding via host ESCRT complex(GO:1903774)
0.3 0.8 GO:0060974 neural crest cell migration involved in heart formation(GO:0003147) cell migration involved in heart formation(GO:0060974) anterior neural tube closure(GO:0061713)
0.3 0.8 GO:0060738 epithelial-mesenchymal signaling involved in prostate gland development(GO:0060738)
0.3 3.3 GO:0021759 globus pallidus development(GO:0021759)
0.3 1.8 GO:0071461 cellular response to redox state(GO:0071461)
0.2 0.9 GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
0.2 0.7 GO:0002416 IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor(GO:0002416)
0.2 1.2 GO:0002501 peptide antigen assembly with MHC protein complex(GO:0002501)
0.2 0.6 GO:1904247 positive regulation of polynucleotide adenylyltransferase activity(GO:1904247)
0.2 1.1 GO:0032571 response to vitamin K(GO:0032571) regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209) bone regeneration(GO:1990523)
0.2 0.7 GO:0097475 motor neuron migration(GO:0097475)
0.2 0.5 GO:0060730 regulation of intestinal epithelial structure maintenance(GO:0060730)
0.2 1.4 GO:0051799 negative regulation of hair follicle development(GO:0051799)
0.2 0.9 GO:0014043 negative regulation of neuron maturation(GO:0014043)
0.2 1.6 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.2 0.8 GO:0097403 cellular response to raffinose(GO:0097403) response to raffinose(GO:1901545)
0.2 0.6 GO:1903045 neural crest cell migration involved in sympathetic nervous system development(GO:1903045)
0.1 0.4 GO:0002644 negative regulation of tolerance induction(GO:0002644) positive regulation of interleukin-4 biosynthetic process(GO:0045404)
0.1 1.2 GO:1902952 positive regulation of dendritic spine maintenance(GO:1902952) regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903756) negative regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903758)
0.1 0.3 GO:0070173 regulation of enamel mineralization(GO:0070173)
0.1 0.6 GO:0002528 regulation of vascular permeability involved in acute inflammatory response(GO:0002528)
0.1 1.4 GO:0090324 negative regulation of oxidative phosphorylation(GO:0090324)
0.1 2.9 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.1 0.6 GO:0014053 negative regulation of gamma-aminobutyric acid secretion(GO:0014053) aspartate secretion(GO:0061528) regulation of aspartate secretion(GO:1904448) positive regulation of aspartate secretion(GO:1904450)
0.1 1.8 GO:0043249 erythrocyte maturation(GO:0043249)
0.1 1.5 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.1 0.3 GO:0070105 positive regulation of interleukin-6-mediated signaling pathway(GO:0070105)
0.1 0.5 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.1 0.3 GO:0043438 acetoacetic acid metabolic process(GO:0043438)
0.1 0.7 GO:0003138 primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185)
0.1 0.3 GO:0099543 retrograde trans-synaptic signaling by soluble gas(GO:0098923) trans-synaptic signaling by soluble gas(GO:0099543) trans-synaptic signaling by trans-synaptic complex(GO:0099545)
0.1 0.4 GO:0009956 radial pattern formation(GO:0009956)
0.1 0.3 GO:1903674 regulation of cap-dependent translational initiation(GO:1903674) positive regulation of cap-dependent translational initiation(GO:1903676)
0.1 0.4 GO:0035627 ceramide transport(GO:0035627)
0.1 0.7 GO:0010133 proline catabolic process to glutamate(GO:0010133)
0.1 2.4 GO:0071850 mitotic cell cycle arrest(GO:0071850)
0.1 0.5 GO:0021780 oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)
0.1 0.5 GO:0060437 lung growth(GO:0060437)
0.1 0.4 GO:0009441 glycolate metabolic process(GO:0009441)
0.1 0.5 GO:0009449 gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.1 1.8 GO:0097264 self proteolysis(GO:0097264)
0.1 1.1 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.1 0.3 GO:0002305 gamma-delta intraepithelial T cell differentiation(GO:0002304) CD8-positive, gamma-delta intraepithelial T cell differentiation(GO:0002305)
0.1 0.2 GO:1904640 response to methionine(GO:1904640)
0.1 0.1 GO:0042668 auditory receptor cell fate determination(GO:0042668)
0.1 5.0 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.1 0.2 GO:0007113 endomitotic cell cycle(GO:0007113)
0.1 0.1 GO:0006540 glutamate decarboxylation to succinate(GO:0006540)
0.1 0.4 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.1 0.4 GO:1900827 maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.1 1.6 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.1 0.3 GO:0060023 soft palate development(GO:0060023)
0.1 0.7 GO:0016199 axon midline choice point recognition(GO:0016199)
0.1 3.4 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.1 1.4 GO:0007379 segment specification(GO:0007379)
0.1 0.8 GO:1904352 positive regulation of protein catabolic process in the vacuole(GO:1904352)
0.1 0.4 GO:0003199 endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199)
0.1 0.2 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)
0.1 0.8 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.1 0.2 GO:1990637 response to prolactin(GO:1990637)
0.1 0.1 GO:0014016 neuroblast differentiation(GO:0014016)
0.1 0.5 GO:0034351 regulation of glial cell apoptotic process(GO:0034350) negative regulation of glial cell apoptotic process(GO:0034351)
0.1 0.7 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.1 2.0 GO:0009954 proximal/distal pattern formation(GO:0009954)
0.1 0.2 GO:0090214 spongiotrophoblast layer developmental growth(GO:0090214)
0.1 1.3 GO:0051639 actin filament network formation(GO:0051639)
0.1 0.2 GO:0061346 non-canonical Wnt signaling pathway involved in heart development(GO:0061341) planar cell polarity pathway involved in heart morphogenesis(GO:0061346)
0.1 0.1 GO:0002331 pre-B cell allelic exclusion(GO:0002331)
0.0 0.7 GO:0072189 ureter development(GO:0072189)
0.0 0.3 GO:0021847 ventricular zone neuroblast division(GO:0021847)
0.0 0.3 GO:1904383 response to sodium phosphate(GO:1904383)
0.0 0.4 GO:2000074 regulation of type B pancreatic cell development(GO:2000074)
0.0 0.3 GO:0061152 trachea submucosa development(GO:0061152) trachea gland development(GO:0061153)
0.0 0.2 GO:0031456 glycine betaine biosynthetic process from choline(GO:0019285) glycine betaine metabolic process(GO:0031455) glycine betaine biosynthetic process(GO:0031456)
0.0 0.2 GO:1901529 positive regulation of anion channel activity(GO:1901529)
0.0 0.4 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.0 0.2 GO:0036269 swimming behavior(GO:0036269)
0.0 0.4 GO:0061669 spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814)
0.0 0.1 GO:2000854 positive regulation of corticosterone secretion(GO:2000854)
0.0 0.3 GO:1905066 arterial endothelial cell fate commitment(GO:0060844) positive regulation of ephrin receptor signaling pathway(GO:1901189) regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901295) positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) regulation of canonical Wnt signaling pathway involved in heart development(GO:1905066) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068)
0.0 0.2 GO:0006420 arginyl-tRNA aminoacylation(GO:0006420)
0.0 0.1 GO:1904897 regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922)
0.0 0.2 GO:0007525 somatic muscle development(GO:0007525)
0.0 0.5 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.0 0.3 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.0 0.2 GO:0016062 adaptation of rhodopsin mediated signaling(GO:0016062) light adaption(GO:0036367)
0.0 0.2 GO:0032233 positive regulation of actin filament bundle assembly(GO:0032233)
0.0 0.1 GO:1904220 regulation of serine C-palmitoyltransferase activity(GO:1904220)
0.0 1.6 GO:0061049 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0 0.2 GO:2000691 regulation of cardiac muscle cell myoblast differentiation(GO:2000690) negative regulation of cardiac muscle cell myoblast differentiation(GO:2000691)
0.0 1.4 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.0 0.1 GO:1902730 regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) positive regulation of proteoglycan biosynthetic process(GO:1902730)
0.0 0.6 GO:0006228 UTP biosynthetic process(GO:0006228)
0.0 1.2 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.0 0.3 GO:0001764 neuron migration(GO:0001764)
0.0 0.6 GO:0002091 negative regulation of receptor internalization(GO:0002091)
0.0 2.9 GO:0061001 regulation of dendritic spine morphogenesis(GO:0061001)
0.0 0.0 GO:1905069 allantois development(GO:1905069)
0.0 0.1 GO:1902725 negative regulation of skeletal muscle cell proliferation(GO:0014859) negative regulation of skeletal muscle satellite cell proliferation(GO:1902723) negative regulation of satellite cell differentiation(GO:1902725)
0.0 0.5 GO:0060287 epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.0 0.3 GO:0018095 protein polyglutamylation(GO:0018095)
0.0 0.3 GO:0046952 ketone body catabolic process(GO:0046952)
0.0 0.4 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.0 0.7 GO:0042135 neurotransmitter catabolic process(GO:0042135)
0.0 3.6 GO:0001578 microtubule bundle formation(GO:0001578)
0.0 0.1 GO:0035038 female pronucleus assembly(GO:0035038)
0.0 0.1 GO:0098582 innate vocalization behavior(GO:0098582)
0.0 0.6 GO:0071481 cellular response to X-ray(GO:0071481)
0.0 0.6 GO:0036342 post-anal tail morphogenesis(GO:0036342)
0.0 0.1 GO:0071638 negative regulation of monocyte chemotactic protein-1 production(GO:0071638)
0.0 0.1 GO:1904879 positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
0.0 0.4 GO:0042693 muscle cell fate commitment(GO:0042693)
0.0 0.2 GO:0000270 peptidoglycan metabolic process(GO:0000270) peptidoglycan catabolic process(GO:0009253)
0.0 0.7 GO:0006068 ethanol catabolic process(GO:0006068)
0.0 0.1 GO:0030311 poly-N-acetyllactosamine biosynthetic process(GO:0030311)
0.0 0.5 GO:0071420 cellular response to histamine(GO:0071420)
0.0 0.8 GO:0009083 branched-chain amino acid catabolic process(GO:0009083)
0.0 0.4 GO:0009886 post-embryonic morphogenesis(GO:0009886)
0.0 0.1 GO:0032072 plasmacytoid dendritic cell activation(GO:0002270) regulation of restriction endodeoxyribonuclease activity(GO:0032072)
0.0 1.0 GO:0001783 B cell apoptotic process(GO:0001783)
0.0 0.3 GO:0021542 dentate gyrus development(GO:0021542)
0.0 0.2 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.0 0.1 GO:0051611 negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.0 0.7 GO:2000121 regulation of removal of superoxide radicals(GO:2000121)
0.0 0.2 GO:1990573 potassium ion import across plasma membrane(GO:1990573)
0.0 0.6 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.0 0.1 GO:0002384 hepatic immune response(GO:0002384)
0.0 0.6 GO:0035855 megakaryocyte development(GO:0035855)
0.0 0.5 GO:0070935 3'-UTR-mediated mRNA stabilization(GO:0070935)
0.0 0.3 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741)
0.0 0.1 GO:0035881 amacrine cell differentiation(GO:0035881)
0.0 0.3 GO:0007258 JUN phosphorylation(GO:0007258)
0.0 0.3 GO:0045974 miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974)
0.0 0.1 GO:0021764 amygdala development(GO:0021764)
0.0 0.2 GO:0046784 viral mRNA export from host cell nucleus(GO:0046784)
0.0 0.1 GO:0070562 regulation of vitamin D receptor signaling pathway(GO:0070562)
0.0 3.7 GO:0007219 Notch signaling pathway(GO:0007219)
0.0 0.6 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.0 0.1 GO:0071477 hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477)
0.0 0.1 GO:0015692 lead ion transport(GO:0015692)
0.0 0.3 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.0 0.2 GO:0035873 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873)
0.0 0.3 GO:0015825 L-serine transport(GO:0015825)
0.0 0.2 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260)
0.0 0.2 GO:0045176 apical protein localization(GO:0045176)
0.0 1.1 GO:0042130 negative regulation of T cell proliferation(GO:0042130)
0.0 0.0 GO:1901846 positive regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901846)
0.0 1.7 GO:0006501 C-terminal protein lipidation(GO:0006501)
0.0 0.1 GO:0006091 generation of precursor metabolites and energy(GO:0006091)
0.0 0.3 GO:0098719 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.0 1.0 GO:0007585 respiratory gaseous exchange(GO:0007585)
0.0 0.1 GO:0001920 negative regulation of receptor recycling(GO:0001920)
0.0 0.2 GO:0007603 phototransduction, visible light(GO:0007603)
0.0 0.3 GO:0060997 dendritic spine morphogenesis(GO:0060997)
0.0 1.4 GO:0018105 peptidyl-serine phosphorylation(GO:0018105)
0.0 0.3 GO:0086069 bundle of His cell to Purkinje myocyte communication(GO:0086069)
0.0 1.1 GO:2000649 regulation of sodium ion transmembrane transporter activity(GO:2000649)
0.0 0.3 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.0 0.5 GO:0051131 chaperone-mediated protein complex assembly(GO:0051131)
0.0 0.1 GO:0060353 regulation of cell adhesion molecule production(GO:0060353) positive regulation of cell adhesion molecule production(GO:0060355)
0.0 0.4 GO:0061458 reproductive system development(GO:0061458)
0.0 0.1 GO:0030299 intestinal cholesterol absorption(GO:0030299) intestinal lipid absorption(GO:0098856)
0.0 0.2 GO:0001542 ovulation from ovarian follicle(GO:0001542)
0.0 0.1 GO:0002933 lipid hydroxylation(GO:0002933)
0.0 0.1 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.0 0.0 GO:0046116 queuosine biosynthetic process(GO:0008616) queuosine metabolic process(GO:0046116)
0.0 0.2 GO:0031507 heterochromatin assembly(GO:0031507)
0.0 0.2 GO:0015868 purine ribonucleotide transport(GO:0015868)
0.0 0.2 GO:0070072 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.0 0.1 GO:0043553 vascular endothelial growth factor receptor-2 signaling pathway(GO:0036324) negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 4.6 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.4 3.2 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.2 1.0 GO:0060187 cell pole(GO:0060187)
0.1 1.6 GO:0071953 elastic fiber(GO:0071953)
0.1 1.3 GO:0042824 MHC class I peptide loading complex(GO:0042824)
0.1 0.6 GO:0032144 4-aminobutyrate transaminase complex(GO:0032144)
0.1 0.7 GO:0014802 terminal cisterna(GO:0014802)
0.1 1.6 GO:0045277 respiratory chain complex IV(GO:0045277)
0.1 0.6 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.1 1.3 GO:0061700 GATOR2 complex(GO:0061700)
0.1 0.9 GO:0005577 fibrinogen complex(GO:0005577)
0.1 1.4 GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
0.1 2.4 GO:0032839 dendrite cytoplasm(GO:0032839)
0.1 0.4 GO:0097209 epidermal lamellar body(GO:0097209)
0.1 4.1 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 0.8 GO:0001673 male germ cell nucleus(GO:0001673)
0.1 0.5 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.0 0.9 GO:0000815 ESCRT III complex(GO:0000815)
0.0 1.3 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.9 GO:0070469 respiratory chain(GO:0070469)
0.0 0.1 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369) catenin-TCF7L2 complex(GO:0071664)
0.0 1.1 GO:0071565 nBAF complex(GO:0071565)
0.0 0.8 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 0.3 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0 1.0 GO:0005605 basal lamina(GO:0005605)
0.0 1.0 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 2.7 GO:0031594 neuromuscular junction(GO:0031594)
0.0 8.4 GO:0043209 myelin sheath(GO:0043209)
0.0 0.2 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.0 7.1 GO:0043197 dendritic spine(GO:0043197)
0.0 1.8 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 0.3 GO:0035068 micro-ribonucleoprotein complex(GO:0035068)
0.0 0.1 GO:0031089 platelet dense granule lumen(GO:0031089)
0.0 0.1 GO:0042585 germinal vesicle(GO:0042585)
0.0 0.2 GO:0098554 cytoplasmic side of endoplasmic reticulum membrane(GO:0098554)
0.0 0.6 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.0 0.2 GO:0033165 interphotoreceptor matrix(GO:0033165)
0.0 0.3 GO:0005583 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.2 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.0 0.2 GO:0032010 phagolysosome(GO:0032010)
0.0 0.1 GO:0005726 perichromatin fibrils(GO:0005726)
0.0 1.2 GO:0001533 cornified envelope(GO:0001533)
0.0 0.1 GO:1990032 parallel fiber(GO:1990032)
0.0 0.3 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 0.3 GO:0000177 cytoplasmic exosome (RNase complex)(GO:0000177)
0.0 0.3 GO:0008290 F-actin capping protein complex(GO:0008290)
0.0 0.2 GO:0005677 chromatin silencing complex(GO:0005677)
0.0 0.1 GO:0070826 paraferritin complex(GO:0070826)
0.0 0.1 GO:0005826 actomyosin contractile ring(GO:0005826)
0.0 0.5 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.2 GO:0036157 outer dynein arm(GO:0036157)
0.0 0.3 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671) IkappaB kinase complex(GO:0008385)
0.0 0.4 GO:0090665 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.6 GO:0000421 autophagosome membrane(GO:0000421)
0.0 0.1 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.0 0.3 GO:0097225 sperm midpiece(GO:0097225)
0.0 2.1 GO:0042383 sarcolemma(GO:0042383)
0.0 0.1 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.0 0.5 GO:0005796 Golgi lumen(GO:0005796)
0.0 1.2 GO:0016459 myosin complex(GO:0016459)
0.0 0.0 GO:0097224 sperm connecting piece(GO:0097224)
0.0 1.2 GO:0005581 collagen trimer(GO:0005581)
0.0 0.4 GO:0097223 sperm part(GO:0097223)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 14.5 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.3 1.5 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.2 1.2 GO:0030021 extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345)
0.2 0.8 GO:0061714 folic acid receptor activity(GO:0061714)
0.2 0.6 GO:0032093 SAM domain binding(GO:0032093)
0.2 0.7 GO:0004657 proline dehydrogenase activity(GO:0004657)
0.1 0.1 GO:0031489 myosin V binding(GO:0031489)
0.1 3.3 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213)
0.1 1.8 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.1 0.7 GO:0019770 IgG receptor activity(GO:0019770)
0.1 0.9 GO:0070728 leucine binding(GO:0070728)
0.1 2.9 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.1 2.2 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.1 0.6 GO:0032145 4-aminobutyrate transaminase activity(GO:0003867) succinate-semialdehyde dehydrogenase binding(GO:0032145) (S)-3-amino-2-methylpropionate transaminase activity(GO:0047298)
0.1 4.4 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 0.3 GO:0016899 oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)
0.1 1.1 GO:0045545 syndecan binding(GO:0045545)
0.1 0.7 GO:0047894 flavonol 3-sulfotransferase activity(GO:0047894) steroid sulfotransferase activity(GO:0050294)
0.1 0.3 GO:0016716 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen(GO:0016716)
0.1 0.4 GO:0034040 lipid-transporting ATPase activity(GO:0034040)
0.1 0.7 GO:0001849 complement component C1q binding(GO:0001849)
0.1 0.7 GO:0008131 primary amine oxidase activity(GO:0008131)
0.1 5.0 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 0.2 GO:0004613 phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613)
0.1 0.5 GO:0004699 calcium-independent protein kinase C activity(GO:0004699)
0.1 0.2 GO:0019781 NEDD8 activating enzyme activity(GO:0019781)
0.1 0.3 GO:0008260 3-oxoacid CoA-transferase activity(GO:0008260)
0.1 0.5 GO:0016681 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.1 0.4 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.1 0.3 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
0.1 0.3 GO:0004167 dopachrome isomerase activity(GO:0004167)
0.1 1.1 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.1 0.3 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.1 0.5 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.1 0.2 GO:1902379 receptor tyrosine kinase-like orphan receptor binding(GO:0005115) chemoattractant activity involved in axon guidance(GO:1902379)
0.1 1.6 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 1.5 GO:0002162 dystroglycan binding(GO:0002162)
0.0 1.7 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 0.1 GO:0031780 corticotropin hormone receptor binding(GO:0031780) type 5 melanocortin receptor binding(GO:0031783)
0.0 0.2 GO:0004977 melanocortin receptor activity(GO:0004977)
0.0 0.2 GO:0004814 arginine-tRNA ligase activity(GO:0004814)
0.0 0.2 GO:0017098 sulfonylurea receptor binding(GO:0017098)
0.0 0.1 GO:0016744 transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
0.0 0.2 GO:0090554 phosphatidylcholine-translocating ATPase activity(GO:0090554)
0.0 0.1 GO:0005148 prolactin receptor binding(GO:0005148)
0.0 0.7 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.5 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.0 11.1 GO:0051015 actin filament binding(GO:0051015)
0.0 0.3 GO:0031013 troponin I binding(GO:0031013)
0.0 0.8 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.2 GO:0004594 pantothenate kinase activity(GO:0004594)
0.0 0.3 GO:0030020 extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.0 0.5 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 6.4 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 0.1 GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
0.0 0.7 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 0.6 GO:0045499 chemorepellent activity(GO:0045499)
0.0 1.3 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.1 GO:0047696 beta-adrenergic receptor kinase activity(GO:0047696)
0.0 0.4 GO:0097109 neuroligin family protein binding(GO:0097109)
0.0 0.3 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 0.2 GO:0015319 sodium:inorganic phosphate symporter activity(GO:0015319)
0.0 0.1 GO:0005415 nucleoside:sodium symporter activity(GO:0005415)
0.0 0.1 GO:0008113 peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.0 0.2 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 0.2 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.0 1.0 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 0.5 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0 0.3 GO:0019865 immunoglobulin binding(GO:0019865)
0.0 0.3 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.1 GO:0070119 ciliary neurotrophic factor binding(GO:0070119)
0.0 0.5 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.3 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.0 0.2 GO:0003796 lysozyme activity(GO:0003796)
0.0 1.0 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 0.2 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 0.2 GO:0004704 NF-kappaB-inducing kinase activity(GO:0004704)
0.0 0.6 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.0 0.3 GO:0000150 recombinase activity(GO:0000150)
0.0 0.2 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 0.1 GO:0034875 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875)
0.0 0.1 GO:0015087 cadmium ion transmembrane transporter activity(GO:0015086) cobalt ion transmembrane transporter activity(GO:0015087) lead ion transmembrane transporter activity(GO:0015094) ferrous iron uptake transmembrane transporter activity(GO:0015639)
0.0 0.4 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.4 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0 0.1 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 0.3 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0 2.1 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 4.4 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.2 GO:0004000 adenosine deaminase activity(GO:0004000)
0.0 0.1 GO:0010858 calcium-dependent protein kinase regulator activity(GO:0010858)
0.0 0.0 GO:0035379 carbon dioxide transmembrane transporter activity(GO:0035379)
0.0 0.1 GO:0031697 beta-1 adrenergic receptor binding(GO:0031697)
0.0 0.7 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.0 0.1 GO:0004859 phospholipase inhibitor activity(GO:0004859)
0.0 0.1 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.0 1.9 GO:0047485 protein N-terminus binding(GO:0047485)
0.0 0.2 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0 1.0 GO:0015078 hydrogen ion transmembrane transporter activity(GO:0015078)
0.0 0.4 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 14.4 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.1 4.6 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 4.5 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.9 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 3.3 PID LKB1 PATHWAY LKB1 signaling events
0.0 5.0 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 1.8 PID ARF6 PATHWAY Arf6 signaling events
0.0 1.5 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 0.9 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.0 1.1 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 2.5 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 0.7 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 1.0 NABA COLLAGENS Genes encoding collagen proteins
0.0 4.7 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.6 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 0.2 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.2 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 0.4 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.6 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.1 2.4 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.1 13.8 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 1.3 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 2.8 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.9 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.0 0.2 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.0 2.2 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.7 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.0 0.6 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.0 0.5 REACTOME ACTIVATED POINT MUTANTS OF FGFR2 Genes involved in Activated point mutants of FGFR2
0.0 0.7 REACTOME DESTABILIZATION OF MRNA BY BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.0 0.9 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 0.7 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 0.5 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.3 REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0 0.3 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 0.4 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 0.3 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.0 0.6 REACTOME PROCESSING OF INTRONLESS PRE MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.0 0.5 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 0.4 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.3 REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 0.8 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 0.5 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.0 0.3 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.4 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.0 0.4 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 0.5 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.3 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 0.4 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.4 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.0 0.4 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.5 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.1 REACTOME SOS MEDIATED SIGNALLING Genes involved in SOS-mediated signalling
0.0 0.5 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.3 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 1.0 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 1.5 REACTOME INTEGRATION OF ENERGY METABOLISM Genes involved in Integration of energy metabolism
0.0 0.5 REACTOME G ALPHA Z SIGNALLING EVENTS Genes involved in G alpha (z) signalling events