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SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for NR1I3

Z-value: 0.43

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Transcription factors associated with NR1I3

Gene Symbol Gene ID Gene Info
ENSG00000143257.7 nuclear receptor subfamily 1 group I member 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NR1I3hg19_v2_chr1_-_161207875_161207901-0.252.8e-01Click!

Activity profile of NR1I3 motif

Sorted Z-values of NR1I3 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr17_+_32582293 2.22 ENST00000580907.1
ENST00000225831.4
chemokine (C-C motif) ligand 2
chr19_+_2977444 1.25 ENST00000246112.4
ENST00000453329.1
ENST00000482627.1
ENST00000452088.1
transducin-like enhancer of split 6 (E(sp1) homolog, Drosophila)
chr9_-_75567962 1.21 ENST00000297785.3
ENST00000376939.1
aldehyde dehydrogenase 1 family, member A1
chr17_-_26695013 1.12 ENST00000555059.2
Homeobox protein SEBOX
chr17_-_26694979 1.08 ENST00000438614.1
vitronectin
chr6_-_127780510 0.87 ENST00000487331.2
ENST00000483725.3
KIAA0408
chr16_-_16317321 0.74 ENST00000205557.7
ENST00000575728.1
ATP-binding cassette, sub-family C (CFTR/MRP), member 6
chr16_-_66968265 0.68 ENST00000567511.1
ENST00000422424.2
family with sequence similarity 96, member B
chr1_-_23886285 0.60 ENST00000374561.5
inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
chr16_-_66968055 0.58 ENST00000568572.1
family with sequence similarity 96, member B
chr1_-_32210275 0.57 ENST00000440175.2
brain-specific angiogenesis inhibitor 2
chr20_+_62339381 0.55 ENST00000355969.6
ENST00000357119.4
ENST00000431125.1
ENST00000369967.3
ENST00000328969.5
zinc finger, CCCH-type with G patch domain
chr17_-_8198636 0.54 ENST00000577745.1
ENST00000579192.1
ENST00000396278.1
solute carrier family 25, member 35
chr12_+_57998400 0.53 ENST00000548804.1
ENST00000550596.1
ENST00000551835.1
ENST00000549583.1
deltex homolog 3 (Drosophila)
chr19_-_46285646 0.51 ENST00000458663.2
dystrophia myotonica-protein kinase
chr20_+_5987890 0.48 ENST00000378868.4
cardiolipin synthase 1
chr19_-_9968816 0.47 ENST00000590841.1
olfactomedin 2
chr1_-_151119087 0.44 ENST00000341697.3
ENST00000368914.3
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C
chr19_-_7562334 0.43 ENST00000593942.1
peroxisomal biogenesis factor 11 gamma
chr16_+_577697 0.43 ENST00000562370.1
ENST00000568988.1
ENST00000219611.2
calpain 15
chr1_-_155159748 0.42 ENST00000473363.2
RP11-201K10.3
chr1_+_45274154 0.42 ENST00000450269.1
ENST00000453418.1
ENST00000409335.2
BTB (POZ) domain containing 19
chr19_-_48894104 0.41 ENST00000597017.1
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1
chr5_+_139055021 0.40 ENST00000502716.1
ENST00000503511.1
CXXC finger protein 5
chr19_+_7562431 0.40 ENST00000361664.2
chromosome 19 open reading frame 45
chr5_+_139055055 0.39 ENST00000511457.1
CXXC finger protein 5
chrX_-_110655391 0.37 ENST00000356915.2
ENST00000356220.3
doublecortin
chr17_-_53499310 0.37 ENST00000262065.3
monocyte to macrophage differentiation-associated
chr2_-_228028829 0.37 ENST00000396625.3
ENST00000329662.7
collagen, type IV, alpha 4
chr2_+_220462560 0.36 ENST00000456909.1
ENST00000295641.10
serine/threonine kinase 11 interacting protein
chr5_+_52856456 0.36 ENST00000296684.5
ENST00000506765.1
NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase)
chr12_+_53693812 0.35 ENST00000549488.1
chromosome 12 open reading frame 10
chr3_-_58419537 0.33 ENST00000474765.1
ENST00000485460.1
ENST00000302746.6
ENST00000383714.4
pyruvate dehydrogenase (lipoamide) beta
chr18_-_19284724 0.33 ENST00000580981.1
ENST00000289119.2
abhydrolase domain containing 3
chr10_-_73848764 0.30 ENST00000317376.4
ENST00000412663.1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
chr19_-_49140692 0.30 ENST00000222122.5
D site of albumin promoter (albumin D-box) binding protein
chr19_-_6604094 0.30 ENST00000597430.2
CD70 molecule
chr8_-_109799793 0.28 ENST00000297459.3
transmembrane protein 74
chr14_+_77787227 0.27 ENST00000216465.5
ENST00000361389.4
ENST00000554279.1
ENST00000557639.1
ENST00000349555.3
ENST00000556627.1
ENST00000557053.1
glutathione S-transferase zeta 1
chr2_-_241075706 0.26 ENST00000607357.1
ENST00000307266.3
myeloma overexpressed 2
chr7_-_56160625 0.23 ENST00000446428.1
ENST00000432123.1
ENST00000452681.2
ENST00000537360.1
phosphorylase kinase, gamma 1 (muscle)
chr9_+_35605274 0.23 ENST00000336395.5
testis-specific kinase 1
chr2_+_177015950 0.22 ENST00000306324.3
homeobox D4
chr1_+_113217043 0.22 ENST00000413052.2
Mov10, Moloney leukemia virus 10, homolog (mouse)
chr19_-_49140609 0.22 ENST00000601104.1
D site of albumin promoter (albumin D-box) binding protein
chr6_+_108487245 0.22 ENST00000368986.4
nuclear receptor subfamily 2, group E, member 1
chr3_+_52350335 0.21 ENST00000420323.2
dynein, axonemal, heavy chain 1
chr15_+_85523671 0.20 ENST00000310298.4
ENST00000557957.1
phosphodiesterase 8A
chr4_+_70894130 0.20 ENST00000526767.1
ENST00000530128.1
ENST00000381057.3
histatin 3
chr2_-_69180012 0.17 ENST00000481498.1
gastrokine 2
chr11_+_62556596 0.17 ENST00000526546.1
transmembrane protein 179B
chr6_-_31509714 0.16 ENST00000456662.1
ENST00000431908.1
ENST00000456976.1
ENST00000428450.1
ENST00000453105.2
ENST00000418897.1
ENST00000415382.2
ENST00000449074.2
ENST00000419020.1
ENST00000428098.1
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
chr1_-_205290865 0.15 ENST00000367157.3
NUAK family, SNF1-like kinase, 2
chr10_+_47658234 0.15 ENST00000447511.2
ENST00000537271.1
anthrax toxin receptor-like
chr11_-_82611448 0.15 ENST00000393399.2
ENST00000313010.3
prolylcarboxypeptidase (angiotensinase C)
chr16_-_4465886 0.15 ENST00000539968.1
coronin 7
chr18_-_33077556 0.14 ENST00000589273.1
ENST00000586489.1
INO80 complex subunit C
chr11_-_59950519 0.14 ENST00000528851.1
membrane-spanning 4-domains, subfamily A, member 6A
chr22_+_42372764 0.14 ENST00000396426.3
ENST00000406029.1
septin 3
chr6_-_31509506 0.14 ENST00000449757.1
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
chr20_-_62339190 0.14 ENST00000324228.2
ENST00000609142.1
ADP-ribosylation factor related protein 1
chr13_-_114107839 0.14 ENST00000375418.3
ADP-ribosylhydrolase like 1
chr11_-_83878041 0.14 ENST00000398299.1
discs, large homolog 2 (Drosophila)
chr3_-_50396978 0.14 ENST00000266025.3
transmembrane protein 115
chr19_-_46296011 0.13 ENST00000377735.3
ENST00000270223.6
dystrophia myotonica, WD repeat containing
chr14_-_22005062 0.13 ENST00000317492.5
spalt-like transcription factor 2
chr18_-_19283649 0.13 ENST00000584464.1
ENST00000578270.1
abhydrolase domain containing 3
chr1_+_32930647 0.11 ENST00000609129.1
zinc finger and BTB domain containing 8B
chr17_-_62502399 0.11 ENST00000450599.2
ENST00000585060.1
DEAD (Asp-Glu-Ala-Asp) box helicase 5
chr19_+_58920102 0.11 ENST00000599238.1
ENST00000322834.7
zinc finger protein 584
chr3_+_122103014 0.11 ENST00000232125.5
ENST00000477892.1
ENST00000469967.1
family with sequence similarity 162, member A
chr4_-_170897045 0.11 ENST00000508313.1
RP11-205M3.3
chr2_-_69180083 0.10 ENST00000328895.4
gastrokine 2
chr17_-_53499218 0.10 ENST00000571578.1
monocyte to macrophage differentiation-associated
chr1_-_9086404 0.10 ENST00000400906.1
solute carrier family 2 (facilitated glucose transporter), member 7
chr13_+_24883703 0.10 ENST00000332018.4
C1q and tumor necrosis factor related protein 9
chr16_-_75018968 0.09 ENST00000262144.6
WD repeat domain 59
chr9_-_91793675 0.09 ENST00000375835.4
ENST00000375830.1
SHC (Src homology 2 domain containing) transforming protein 3
chr1_-_149900122 0.09 ENST00000271628.8
splicing factor 3b, subunit 4, 49kDa
chr1_-_33336414 0.09 ENST00000373471.3
ENST00000609187.1
fibronectin type III domain containing 5
chr16_+_67280799 0.09 ENST00000566345.2
solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5
chr12_-_54779511 0.09 ENST00000551109.1
ENST00000546970.1
zinc finger protein 385A
chr10_-_50396407 0.08 ENST00000374153.2
ENST00000374151.3
chromosome 10 open reading frame 128
chr1_-_20126365 0.08 ENST00000294543.6
ENST00000375122.2
transmembrane and coiled-coil domains 4
chrX_+_110924346 0.08 ENST00000371979.3
ENST00000251943.4
ENST00000486353.1
ENST00000394780.3
ENST00000495283.1
ALG13, UDP-N-acetylglucosaminyltransferase subunit
chr22_+_39493207 0.08 ENST00000348946.4
ENST00000442487.3
ENST00000421988.2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H
chrX_-_39186610 0.08 ENST00000429281.1
ENST00000448597.1
RP11-265P11.2
chr9_-_35361262 0.07 ENST00000599954.1
HCG17281; PRO0038; Uncharacterized protein
chr14_-_77787198 0.07 ENST00000261534.4
protein-O-mannosyltransferase 2
chr11_+_63137251 0.07 ENST00000310969.4
ENST00000279178.3
solute carrier family 22 (organic anion transporter), member 9
chr3_-_116164306 0.07 ENST00000490035.2
limbic system-associated membrane protein
chr8_-_52721975 0.06 ENST00000356297.4
ENST00000543296.1
peroxidasin homolog (Drosophila)-like
chr1_+_59250815 0.06 ENST00000544621.1
ENST00000419531.2
long intergenic non-protein coding RNA 1135
chr17_-_33390667 0.06 ENST00000378516.2
ENST00000268850.7
ENST00000394597.2
ring finger and FYVE-like domain containing E3 ubiquitin protein ligase
chr19_+_58919992 0.06 ENST00000306910.4
ENST00000598901.1
ENST00000593920.1
ENST00000596281.1
zinc finger protein 584
chr20_-_44007014 0.06 ENST00000372726.3
ENST00000537995.1
TP53 target 5
chr19_+_676385 0.06 ENST00000166139.4
follistatin-like 3 (secreted glycoprotein)
chr1_+_43803475 0.06 ENST00000372470.3
ENST00000413998.2
myeloproliferative leukemia virus oncogene
chr6_-_43496605 0.06 ENST00000455285.2
exportin 5
chr11_-_104480019 0.05 ENST00000536529.1
ENST00000545630.1
ENST00000538641.1
RP11-886D15.1
chr12_-_75601778 0.05 ENST00000550433.1
ENST00000548513.1
potassium voltage-gated channel, Shaw-related subfamily, member 2
chr5_+_156712372 0.05 ENST00000541131.1
cytoplasmic FMR1 interacting protein 2
chrX_+_118602363 0.05 ENST00000317881.8
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
chr14_+_100070869 0.05 ENST00000502101.2
RP11-543C4.1
chr12_+_49208234 0.05 ENST00000540990.1
calcium channel, voltage-dependent, beta 3 subunit
chr20_-_62339315 0.05 ENST00000440854.1
ENST00000607873.1
ADP-ribosylation factor related protein 1
chr7_-_56160666 0.05 ENST00000297373.2
phosphorylase kinase, gamma 1 (muscle)
chr17_+_26833250 0.05 ENST00000577936.1
ENST00000579795.1
forkhead box N1
chr11_-_83393303 0.04 ENST00000398304.1
ENST00000420775.2
discs, large homolog 2 (Drosophila)
chr6_-_34113856 0.04 ENST00000538487.2
glutamate receptor, metabotropic 4
chr1_-_27682962 0.04 ENST00000486046.1
mitogen-activated protein kinase kinase kinase 6
chr4_+_37245799 0.04 ENST00000309447.5
KIAA1239
chr2_-_236692031 0.04 ENST00000440101.1
Uncharacterized protein
chr12_-_108991778 0.04 ENST00000549447.1
transmembrane protein 119
chr1_+_160097462 0.03 ENST00000447527.1
ATPase, Na+/K+ transporting, alpha 2 polypeptide
chr22_+_39493268 0.03 ENST00000401756.1
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H
chr8_+_11351876 0.03 ENST00000529894.1
B lymphoid tyrosine kinase
chr9_+_37486005 0.03 ENST00000377792.3
polymerase (RNA) I polypeptide E, 53kDa
chr3_-_116163830 0.02 ENST00000333617.4
limbic system-associated membrane protein
chr1_+_26036093 0.02 ENST00000374329.1
mannosidase, alpha, class 1C, member 1
chr17_-_34270697 0.02 ENST00000585556.1
lysozyme-like 6
chr11_+_105480740 0.01 ENST00000393125.2
glutamate receptor, ionotropic, AMPA 4
chr17_-_34270668 0.01 ENST00000293274.4
lysozyme-like 6
chr10_+_47657581 0.01 ENST00000441923.2
anthrax toxin receptor-like
chr17_-_3301704 0.01 ENST00000322608.2
olfactory receptor, family 1, subfamily E, member 1
chr12_-_108991812 0.01 ENST00000392806.3
ENST00000547567.1
transmembrane protein 119
chr10_+_88414338 0.00 ENST00000241891.5
ENST00000443292.1
opsin 4
chr13_-_95131923 0.00 ENST00000377028.5
ENST00000446125.1
dopachrome tautomerase
chr9_-_80646374 0.00 ENST00000286548.4
guanine nucleotide binding protein (G protein), q polypeptide

Network of associatons between targets according to the STRING database.

First level regulatory network of NR1I3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.2 GO:2000502 negative regulation of natural killer cell chemotaxis(GO:2000502)
0.2 1.2 GO:0061624 fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624)
0.1 1.2 GO:0060136 embryonic process involved in female pregnancy(GO:0060136)
0.1 0.2 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.1 0.5 GO:1904386 response to thyroxine(GO:0097068) response to L-phenylalanine derivative(GO:1904386)
0.1 0.4 GO:0044375 regulation of peroxisome size(GO:0044375)
0.0 1.3 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0 1.1 GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030949)
0.0 0.5 GO:0014722 regulation of skeletal muscle contraction by calcium ion signaling(GO:0014722)
0.0 0.3 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.0 0.4 GO:0006621 protein retention in ER lumen(GO:0006621)
0.0 0.3 GO:0006572 tyrosine catabolic process(GO:0006572)
0.0 0.3 GO:2000002 negative regulation of DNA damage checkpoint(GO:2000002)
0.0 0.5 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.0 0.5 GO:0051152 positive regulation of smooth muscle cell differentiation(GO:0051152)
0.0 0.4 GO:0035641 locomotory exploration behavior(GO:0035641)
0.0 0.2 GO:0002353 regulation of thyroid hormone mediated signaling pathway(GO:0002155) kinin cascade(GO:0002254) plasma kallikrein-kinin cascade(GO:0002353)
0.0 0.2 GO:0035279 mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795)
0.0 0.6 GO:0030903 notochord development(GO:0030903)
0.0 0.1 GO:0038163 thrombopoietin-mediated signaling pathway(GO:0038163)
0.0 0.1 GO:0035281 pre-miRNA export from nucleus(GO:0035281)
0.0 0.1 GO:0051725 protein de-ADP-ribosylation(GO:0051725)
0.0 0.4 GO:0032836 glomerular basement membrane development(GO:0032836)
0.0 0.4 GO:0001764 neuron migration(GO:0001764)
0.0 0.1 GO:0070383 DNA cytosine deamination(GO:0070383)
0.0 0.0 GO:0097534 lymphoid lineage cell migration(GO:0097534) lymphoid lineage cell migration into thymus(GO:0097535) regulation of positive thymic T cell selection(GO:1902232)
0.0 0.1 GO:1904098 regulation of protein O-linked glycosylation(GO:1904098) positive regulation of protein O-linked glycosylation(GO:1904100)
0.0 0.3 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 0.1 GO:1902162 mRNA localization resulting in posttranscriptional regulation of gene expression(GO:0010609) regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902162) positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902164)
0.0 0.2 GO:0036159 inner dynein arm assembly(GO:0036159)
0.0 0.0 GO:1903280 negative regulation of calcium:sodium antiporter activity(GO:1903280)
0.0 0.1 GO:2001271 negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.1 GO:0071062 rough endoplasmic reticulum lumen(GO:0048237) alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.2 1.3 GO:0071817 MMXD complex(GO:0071817)
0.0 0.2 GO:0036156 inner dynein arm(GO:0036156)
0.0 0.4 GO:0005587 collagen type IV trimer(GO:0005587)
0.0 0.3 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.0 0.3 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.0 0.3 GO:0005688 U6 snRNP(GO:0005688)
0.0 0.1 GO:0002947 tumor necrosis factor receptor superfamily complex(GO:0002947)
0.0 0.1 GO:0042565 RNA nuclear export complex(GO:0042565)
0.0 0.4 GO:0030663 COPI-coated vesicle membrane(GO:0030663)
0.0 0.5 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 0.4 GO:0031231 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.0 0.1 GO:0043541 UDP-N-acetylglucosamine transferase complex(GO:0043541)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0043337 cardiolipin synthase activity(GO:0008808) phosphatidyltransferase activity(GO:0030572) CDP-diacylglycerol-phosphatidylglycerol phosphatidyltransferase activity(GO:0043337)
0.1 1.2 GO:0018479 benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.1 0.3 GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.1 0.4 GO:0005046 KDEL sequence binding(GO:0005046)
0.1 0.5 GO:0052740 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740)
0.1 2.2 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.0 0.7 GO:0043225 anion transmembrane-transporting ATPase activity(GO:0043225)
0.0 1.1 GO:0001871 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0 0.3 GO:0030621 U4 snRNA binding(GO:0030621)
0.0 0.3 GO:0004689 phosphorylase kinase activity(GO:0004689)
0.0 0.1 GO:0003875 ADP-ribosylarginine hydrolase activity(GO:0003875)
0.0 0.1 GO:0090631 pre-miRNA transporter activity(GO:0090631)
0.0 0.1 GO:0004126 cytidine deaminase activity(GO:0004126)
0.0 0.1 GO:0005471 ATP:ADP antiporter activity(GO:0005471) adenine transmembrane transporter activity(GO:0015207)
0.0 0.1 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.2 PID IL23 PATHWAY IL23-mediated signaling events
0.0 1.1 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.4 PID ARF 3PATHWAY Arf1 pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.1 2.2 REACTOME ACTIVATION OF GENES BY ATF4 Genes involved in Activation of Genes by ATF4
0.0 0.5 REACTOME ACYL CHAIN REMODELLING OF PG Genes involved in Acyl chain remodelling of PG
0.0 0.3 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.1 REACTOME PLATELET AGGREGATION PLUG FORMATION Genes involved in Platelet Aggregation (Plug Formation)
0.0 0.7 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport