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SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for NRF1
Z-value: 5.20
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Transcription factors associated with NRF1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NRF1 | hg19_v2_chr7_+_129251531_129251601 | 0.93 | 2.9e-09 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of NRF1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.0 | 22.2 | GO:0045876 | positive regulation of sister chromatid cohesion(GO:0045876) |
| 0.5 | 19.2 | GO:0034080 | CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641) |
| 0.2 | 18.7 | GO:0007062 | sister chromatid cohesion(GO:0007062) |
| 1.3 | 15.9 | GO:0010032 | meiotic chromosome condensation(GO:0010032) |
| 3.1 | 15.4 | GO:1903615 | regulation of protein tyrosine phosphatase activity(GO:1903613) positive regulation of protein tyrosine phosphatase activity(GO:1903615) |
| 0.1 | 13.5 | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146) |
| 1.0 | 12.7 | GO:0098870 | neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870) |
| 1.3 | 12.6 | GO:2001300 | lipoxin metabolic process(GO:2001300) |
| 0.8 | 12.5 | GO:0034501 | protein localization to kinetochore(GO:0034501) |
| 0.3 | 12.5 | GO:0043928 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 34.4 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.3 | 32.3 | GO:0000777 | condensed chromosome kinetochore(GO:0000777) |
| 0.0 | 22.7 | GO:0005635 | nuclear envelope(GO:0005635) |
| 2.1 | 21.1 | GO:0000798 | nuclear cohesin complex(GO:0000798) |
| 1.6 | 20.7 | GO:0000796 | condensin complex(GO:0000796) |
| 2.9 | 20.4 | GO:0005658 | alpha DNA polymerase:primase complex(GO:0005658) |
| 0.1 | 18.0 | GO:0005819 | spindle(GO:0005819) |
| 0.2 | 16.9 | GO:0016235 | aggresome(GO:0016235) |
| 0.4 | 14.3 | GO:0043218 | compact myelin(GO:0043218) |
| 0.0 | 13.9 | GO:0016324 | apical plasma membrane(GO:0016324) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 33.4 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 2.6 | 18.2 | GO:0061575 | cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575) |
| 0.4 | 16.3 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.0 | 13.9 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.3 | 12.7 | GO:0044183 | protein binding involved in protein folding(GO:0044183) |
| 3.2 | 12.6 | GO:0016404 | 15-hydroxyprostaglandin dehydrogenase (NAD+) activity(GO:0016404) |
| 0.3 | 12.3 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.4 | 12.1 | GO:0017056 | structural constituent of nuclear pore(GO:0017056) |
| 0.3 | 11.0 | GO:0051537 | 2 iron, 2 sulfur cluster binding(GO:0051537) |
| 0.2 | 10.8 | GO:0030159 | receptor signaling complex scaffold activity(GO:0030159) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 59.7 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.3 | 25.7 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.2 | 13.6 | PID PI3KCI AKT PATHWAY | Class I PI3K signaling events mediated by Akt |
| 0.3 | 13.4 | PID IL8 CXCR1 PATHWAY | IL8- and CXCR1-mediated signaling events |
| 0.1 | 13.3 | PID P73PATHWAY | p73 transcription factor network |
| 0.1 | 10.2 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.9 | 8.9 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.1 | 7.6 | PID ERBB1 DOWNSTREAM PATHWAY | ErbB1 downstream signaling |
| 0.2 | 7.3 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.1 | 5.8 | PID A6B1 A6B4 INTEGRIN PATHWAY | a6b1 and a6b4 Integrin signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 92.3 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 1.4 | 27.3 | REACTOME POL SWITCHING | Genes involved in Polymerase switching |
| 0.4 | 17.6 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.3 | 16.5 | REACTOME TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT | Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript |
| 0.9 | 15.8 | REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION | Genes involved in E2F-enabled inhibition of pre-replication complex formation |
| 0.2 | 15.8 | REACTOME SCFSKP2 MEDIATED DEGRADATION OF P27 P21 | Genes involved in SCF(Skp2)-mediated degradation of p27/p21 |
| 0.4 | 14.4 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |
| 0.6 | 11.9 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.2 | 11.7 | REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS | Genes involved in Post-translational modification: synthesis of GPI-anchored proteins |
| 0.7 | 11.5 | REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK | Genes involved in Negative regulation of the PI3K/AKT network |