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SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4

Z-value: 0.56

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Transcription factors associated with OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4

Gene Symbol Gene ID Gene Info
OTP
ENSG00000171540.6 orthopedia homeobox
PHOX2B
ENSG00000109132.5 paired like homeobox 2B
LHX1
ENSG00000132130.7 LIM homeobox 1
LMX1A
ENSG00000162761.10 LIM homeobox transcription factor 1 alpha
LHX5
ENSG00000089116.3 LIM homeobox 5
HOXC4
ENSG00000198353.6 homeobox C4
HOXC4
ENSG00000273266.1 homeobox C4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
LHX1hg19_v2_chr17_+_35294075_35294102-0.531.6e-02Click!
HOXC4hg19_v2_chr12_+_54447637_54447661-0.417.0e-02Click!
LHX5hg19_v2_chr12_-_113909877_1139098770.321.7e-01Click!
OTPhg19_v2_chr5_-_76935513_76935513-0.116.4e-01Click!

Activity profile of OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4 motif

Sorted Z-values of OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr11_-_327537 2.63 ENST00000602735.1
IFITM3
interferon induced transmembrane protein 3
chrX_+_43515467 1.92 ENST00000338702.3
ENST00000542639.1
MAOA
monoamine oxidase A
chr5_-_126409159 1.58 ENST00000607731.1
ENST00000535381.1
ENST00000296662.5
ENST00000509733.3
C5orf63
chromosome 5 open reading frame 63
chr17_+_1674982 1.33 ENST00000572048.1
ENST00000573763.1
SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr19_+_49199209 1.14 ENST00000522966.1
ENST00000425340.2
ENST00000391876.4
FUT2
fucosyltransferase 2 (secretor status included)
chr15_+_101417919 1.10 ENST00000561338.1
ALDH1A3
aldehyde dehydrogenase 1 family, member A3
chr12_+_4385230 1.09 ENST00000536537.1
CCND2
cyclin D2
chr11_+_5710919 0.92 ENST00000379965.3
ENST00000425490.1
TRIM22
tripartite motif containing 22
chr19_-_36304201 0.90 ENST00000301175.3
PRODH2
proline dehydrogenase (oxidase) 2
chr7_+_150020363 0.78 ENST00000359623.4
ENST00000493307.1
LRRC61
leucine rich repeat containing 61
chr5_+_66300464 0.76 ENST00000436277.1
MAST4
microtubule associated serine/threonine kinase family member 4
chr19_-_36001113 0.70 ENST00000434389.1
DMKN
dermokine
chr7_+_150020329 0.65 ENST00000323078.7
LRRC61
leucine rich repeat containing 61
chr16_-_28634874 0.64 ENST00000395609.1
ENST00000350842.4
SULT1A1
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
chr5_+_66300446 0.59 ENST00000261569.7
MAST4
microtubule associated serine/threonine kinase family member 4
chr1_+_160370344 0.59 ENST00000368061.2
VANGL2
VANGL planar cell polarity protein 2
chr10_-_105845674 0.55 ENST00000353479.5
ENST00000369733.3
COL17A1
collagen, type XVII, alpha 1
chr11_+_35222629 0.54 ENST00000526553.1
CD44
CD44 molecule (Indian blood group)
chr12_-_10022735 0.54 ENST00000228438.2
CLEC2B
C-type lectin domain family 2, member B
chr1_+_117544366 0.54 ENST00000256652.4
ENST00000369470.1
CD101
CD101 molecule
chr19_+_50016610 0.52 ENST00000596975.1
FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr15_+_94899183 0.51 ENST00000557742.1
MCTP2
multiple C2 domains, transmembrane 2
chr4_+_155484103 0.50 ENST00000302068.4
FGB
fibrinogen beta chain
chr4_+_155484155 0.50 ENST00000509493.1
FGB
fibrinogen beta chain
chr10_-_105845536 0.49 ENST00000393211.3
COL17A1
collagen, type XVII, alpha 1
chr18_-_47018769 0.47 ENST00000583637.1
ENST00000578528.1
ENST00000578532.1
ENST00000580387.1
ENST00000579248.1
ENST00000581373.1
RPL17
ribosomal protein L17
chr18_-_47018869 0.47 ENST00000583036.1
ENST00000580261.1
RPL17
ribosomal protein L17
chr7_+_5465382 0.46 ENST00000609130.1
RP11-1275H24.2
RP11-1275H24.2
chr11_-_128894053 0.46 ENST00000392657.3
ARHGAP32
Rho GTPase activating protein 32
chr7_-_22862406 0.44 ENST00000372879.4
TOMM7
translocase of outer mitochondrial membrane 7 homolog (yeast)
chr3_-_185538849 0.43 ENST00000421047.2
IGF2BP2
insulin-like growth factor 2 mRNA binding protein 2
chr10_+_24755416 0.41 ENST00000396446.1
ENST00000396445.1
ENST00000376451.2
KIAA1217
KIAA1217
chr6_+_130339710 0.40 ENST00000526087.1
ENST00000533560.1
ENST00000361794.2
L3MBTL3
l(3)mbt-like 3 (Drosophila)
chr18_-_47018897 0.38 ENST00000418495.1
RPL17
ribosomal protein L17
chrM_-_14670 0.38 ENST00000361681.2
MT-ND6
mitochondrially encoded NADH dehydrogenase 6
chr5_+_166711804 0.37 ENST00000518659.1
ENST00000545108.1
TENM2
teneurin transmembrane protein 2
chr19_+_50016411 0.35 ENST00000426395.3
ENST00000600273.1
ENST00000599988.1
FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr3_-_12587055 0.35 ENST00000564146.3
C3orf83
chromosome 3 open reading frame 83
chr6_+_114178512 0.35 ENST00000368635.4
MARCKS
myristoylated alanine-rich protein kinase C substrate
chr7_-_150020750 0.34 ENST00000539352.1
ACTR3C
ARP3 actin-related protein 3 homolog C (yeast)
chr17_-_39093672 0.34 ENST00000209718.3
ENST00000436344.3
ENST00000485751.1
KRT23
keratin 23 (histone deacetylase inducible)
chr6_+_26440700 0.34 ENST00000494393.1
ENST00000482451.1
ENST00000244519.2
ENST00000339789.4
ENST00000471353.1
ENST00000361232.3
ENST00000487627.1
ENST00000496719.1
ENST00000490254.1
ENST00000487272.1
BTN3A3
butyrophilin, subfamily 3, member A3
chr7_-_150020578 0.34 ENST00000478393.1
ACTR3C
ARP3 actin-related protein 3 homolog C (yeast)
chr12_+_104337515 0.33 ENST00000550595.1
HSP90B1
heat shock protein 90kDa beta (Grp94), member 1
chr11_+_327171 0.32 ENST00000534483.1
ENST00000524824.1
ENST00000531076.1
RP11-326C3.12
RP11-326C3.12
chrX_+_1710484 0.32 ENST00000313871.3
ENST00000381261.3
AKAP17A
A kinase (PRKA) anchor protein 17A
chr3_-_151034734 0.32 ENST00000260843.4
GPR87
G protein-coupled receptor 87
chr3_+_111717511 0.30 ENST00000478951.1
ENST00000393917.2
TAGLN3
transgelin 3
chr4_-_68829226 0.30 ENST00000396188.2
TMPRSS11A
transmembrane protease, serine 11A
chr19_-_14064114 0.29 ENST00000585607.1
ENST00000538517.2
ENST00000587458.1
ENST00000538371.2
PODNL1
podocan-like 1
chr3_-_141747950 0.29 ENST00000497579.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr2_+_182850743 0.29 ENST00000409702.1
PPP1R1C
protein phosphatase 1, regulatory (inhibitor) subunit 1C
chr6_-_32157947 0.28 ENST00000375050.4
PBX2
pre-B-cell leukemia homeobox 2
chr20_+_22034809 0.28 ENST00000449427.1
RP11-125P18.1
RP11-125P18.1
chr3_+_111718036 0.27 ENST00000455401.2
TAGLN3
transgelin 3
chr10_-_28571015 0.26 ENST00000375719.3
ENST00000375732.1
MPP7
membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)
chr12_-_22063787 0.26 ENST00000544039.1
ABCC9
ATP-binding cassette, sub-family C (CFTR/MRP), member 9
chr7_+_133812052 0.26 ENST00000285928.2
LRGUK
leucine-rich repeats and guanylate kinase domain containing
chr8_-_49834299 0.25 ENST00000396822.1
SNAI2
snail family zinc finger 2
chr8_-_49833978 0.24 ENST00000020945.1
SNAI2
snail family zinc finger 2
chr6_-_138833630 0.24 ENST00000533765.1
NHSL1
NHS-like 1
chr1_-_201140673 0.23 ENST00000367333.2
TMEM9
transmembrane protein 9
chr5_+_40841276 0.23 ENST00000254691.5
CARD6
caspase recruitment domain family, member 6
chr7_-_150020814 0.23 ENST00000477871.1
ACTR3C
ARP3 actin-related protein 3 homolog C (yeast)
chr1_-_92952433 0.23 ENST00000294702.5
GFI1
growth factor independent 1 transcription repressor
chr4_+_76481258 0.23 ENST00000311623.4
ENST00000435974.2
C4orf26
chromosome 4 open reading frame 26
chr3_-_150421752 0.23 ENST00000498386.1
FAM194A
family with sequence similarity 194, member A
chr4_-_68829144 0.23 ENST00000508048.1
TMPRSS11A
transmembrane protease, serine 11A
chr18_+_61254570 0.22 ENST00000344731.5
SERPINB13
serpin peptidase inhibitor, clade B (ovalbumin), member 13
chr3_+_111717600 0.22 ENST00000273368.4
TAGLN3
transgelin 3
chr15_+_75970672 0.22 ENST00000435356.1
AC105020.1
Uncharacterized protein; cDNA FLJ12988 fis, clone NT2RP3000080
chr11_-_8857248 0.22 ENST00000534248.1
ENST00000530959.1
ENST00000531578.1
ENST00000533225.1
ST5
suppression of tumorigenicity 5
chr11_-_13011081 0.22 ENST00000532541.1
ENST00000526388.1
ENST00000534477.1
ENST00000531402.1
ENST00000527945.1
ENST00000504230.2
LINC00958
long intergenic non-protein coding RNA 958
chr17_-_72772462 0.21 ENST00000582870.1
ENST00000581136.1
ENST00000357814.3
ENST00000579218.1
ENST00000583476.1
ENST00000580301.1
ENST00000583757.1
ENST00000582524.1
NAT9
N-acetyltransferase 9 (GCN5-related, putative)
chr18_+_61254534 0.20 ENST00000269489.5
SERPINB13
serpin peptidase inhibitor, clade B (ovalbumin), member 13
chr2_+_102953608 0.20 ENST00000311734.2
ENST00000409584.1
IL1RL1
interleukin 1 receptor-like 1
chr7_+_129932974 0.20 ENST00000445470.2
ENST00000222482.4
ENST00000492072.1
ENST00000473956.1
ENST00000493259.1
ENST00000486598.1
CPA4
carboxypeptidase A4
chr19_+_21324827 0.19 ENST00000600692.1
ENST00000599296.1
ENST00000594425.1
ENST00000311048.7
ZNF431
zinc finger protein 431
chr18_+_47087055 0.19 ENST00000577628.1
LIPG
lipase, endothelial
chr14_-_104387888 0.19 ENST00000286953.3
C14orf2
chromosome 14 open reading frame 2
chrM_+_14741 0.19 ENST00000361789.2
MT-CYB
mitochondrially encoded cytochrome b
chr4_+_26324474 0.19 ENST00000514675.1
RBPJ
recombination signal binding protein for immunoglobulin kappa J region
chr4_-_74486109 0.19 ENST00000395777.2
RASSF6
Ras association (RalGDS/AF-6) domain family member 6
chr7_-_22862448 0.19 ENST00000358435.4
TOMM7
translocase of outer mitochondrial membrane 7 homolog (yeast)
chr13_-_81801115 0.18 ENST00000567258.1
LINC00564
long intergenic non-protein coding RNA 564
chr12_-_15114603 0.18 ENST00000228945.4
ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chr2_+_182850551 0.17 ENST00000452904.1
ENST00000409137.3
ENST00000280295.3
PPP1R1C
protein phosphatase 1, regulatory (inhibitor) subunit 1C
chr12_-_46121554 0.17 ENST00000609803.1
LINC00938
long intergenic non-protein coding RNA 938
chr13_-_38172863 0.17 ENST00000541481.1
ENST00000379743.4
ENST00000379742.4
ENST00000379749.4
ENST00000541179.1
ENST00000379747.4
POSTN
periostin, osteoblast specific factor
chr6_-_47445214 0.17 ENST00000604014.1
RP11-385F7.1
RP11-385F7.1
chr3_-_141719195 0.17 ENST00000397991.4
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr11_+_71934962 0.17 ENST00000543234.1
INPPL1
inositol polyphosphate phosphatase-like 1
chr12_+_26348246 0.17 ENST00000422622.2
SSPN
sarcospan
chr5_+_81575281 0.17 ENST00000380167.4
ATP6AP1L
ATPase, H+ transporting, lysosomal accessory protein 1-like
chr11_-_121986923 0.16 ENST00000560104.1
BLID
BH3-like motif containing, cell death inducer
chr5_+_40841410 0.16 ENST00000381677.3
CARD6
caspase recruitment domain family, member 6
chr5_-_41794313 0.16 ENST00000512084.1
OXCT1
3-oxoacid CoA transferase 1
chr2_+_166095898 0.16 ENST00000424833.1
ENST00000375437.2
ENST00000357398.3
SCN2A
sodium channel, voltage-gated, type II, alpha subunit
chr21_+_33671160 0.15 ENST00000303645.5
MRAP
melanocortin 2 receptor accessory protein
chr7_-_87342564 0.15 ENST00000265724.3
ENST00000416177.1
ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
chr14_+_103851712 0.15 ENST00000440884.3
ENST00000416682.2
ENST00000429436.2
ENST00000303622.9
MARK3
MAP/microtubule affinity-regulating kinase 3
chr6_-_133035185 0.15 ENST00000367928.4
VNN1
vanin 1
chr15_-_34635314 0.15 ENST00000557912.1
ENST00000328848.4
NOP10
NOP10 ribonucleoprotein
chr7_+_138915102 0.15 ENST00000486663.1
UBN2
ubinuclein 2
chr3_+_139063372 0.15 ENST00000478464.1
MRPS22
mitochondrial ribosomal protein S22
chr18_-_32870148 0.14 ENST00000589178.1
ENST00000333206.5
ENST00000592278.1
ENST00000592211.1
ENST00000420878.3
ENST00000383091.2
ENST00000586922.2
ZSCAN30
RP11-158H5.7
zinc finger and SCAN domain containing 30
RP11-158H5.7
chr16_-_66583701 0.14 ENST00000527800.1
ENST00000525974.1
ENST00000563369.2
TK2
thymidine kinase 2, mitochondrial
chr1_+_151253991 0.14 ENST00000443959.1
ZNF687
zinc finger protein 687
chr12_-_15114191 0.14 ENST00000541380.1
ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chr12_+_4130143 0.14 ENST00000543206.1
RP11-320N7.2
RP11-320N7.2
chr7_-_44580861 0.14 ENST00000546276.1
ENST00000289547.4
ENST00000381160.3
ENST00000423141.1
NPC1L1
NPC1-like 1
chr13_-_36050819 0.14 ENST00000379919.4
MAB21L1
mab-21-like 1 (C. elegans)
chr4_+_75174180 0.14 ENST00000413830.1
EPGN
epithelial mitogen
chr1_-_168464875 0.13 ENST00000422253.1
RP5-968D22.3
RP5-968D22.3
chr12_-_64062583 0.13 ENST00000542209.1
DPY19L2
dpy-19-like 2 (C. elegans)
chr3_+_111718173 0.13 ENST00000494932.1
TAGLN3
transgelin 3
chrX_+_55744228 0.13 ENST00000262850.7
RRAGB
Ras-related GTP binding B
chr4_+_37455536 0.13 ENST00000381980.4
ENST00000508175.1
C4orf19
chromosome 4 open reading frame 19
chr14_+_72052983 0.13 ENST00000358550.2
SIPA1L1
signal-induced proliferation-associated 1 like 1
chr12_-_15114658 0.13 ENST00000542276.1
ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chr12_-_15114492 0.13 ENST00000541546.1
ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chr16_-_28937027 0.12 ENST00000358201.4
RABEP2
rabaptin, RAB GTPase binding effector protein 2
chr6_+_42584847 0.12 ENST00000372883.3
UBR2
ubiquitin protein ligase E3 component n-recognin 2
chr18_+_47087390 0.12 ENST00000583083.1
LIPG
lipase, endothelial
chr3_+_43020773 0.12 ENST00000488863.1
FAM198A
family with sequence similarity 198, member A
chr2_+_68961934 0.12 ENST00000409202.3
ARHGAP25
Rho GTPase activating protein 25
chr20_-_50418947 0.12 ENST00000371539.3
SALL4
spalt-like transcription factor 4
chr2_+_102615416 0.12 ENST00000393414.2
IL1R2
interleukin 1 receptor, type II
chr7_-_144435985 0.12 ENST00000549981.1
TPK1
thiamin pyrophosphokinase 1
chr17_+_68164752 0.11 ENST00000535240.1
KCNJ2
potassium inwardly-rectifying channel, subfamily J, member 2
chr19_+_36139125 0.11 ENST00000246554.3
COX6B1
cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous)
chr8_-_29605625 0.11 ENST00000506121.3
LINC00589
long intergenic non-protein coding RNA 589
chr11_-_559377 0.11 ENST00000486629.1
C11orf35
chromosome 11 open reading frame 35
chr4_-_36245561 0.11 ENST00000506189.1
ARAP2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr8_-_90769422 0.11 ENST00000524190.1
ENST00000523859.1
RP11-37B2.1
RP11-37B2.1
chr4_-_177116772 0.10 ENST00000280191.2
SPATA4
spermatogenesis associated 4
chr9_+_124329336 0.10 ENST00000394340.3
ENST00000436835.1
ENST00000259371.2
DAB2IP
DAB2 interacting protein
chr19_+_56280507 0.10 ENST00000341750.4
RFPL4AL1
ret finger protein-like 4A-like 1
chr12_-_112123524 0.10 ENST00000327551.6
BRAP
BRCA1 associated protein
chr7_+_30589829 0.10 ENST00000579437.1
RP4-777O23.1
RP4-777O23.1
chr12_+_25205666 0.10 ENST00000547044.1
LRMP
lymphoid-restricted membrane protein
chr10_-_118928543 0.10 ENST00000419373.2
RP11-501J20.2
RP11-501J20.2
chr13_+_46276441 0.10 ENST00000310521.1
ENST00000533564.1
SPERT
spermatid associated
chr2_+_68961905 0.10 ENST00000295381.3
ARHGAP25
Rho GTPase activating protein 25
chr14_-_75530693 0.10 ENST00000555135.1
ENST00000357971.3
ENST00000553302.1
ENST00000555694.1
ENST00000238618.3
ACYP1
acylphosphatase 1, erythrocyte (common) type
chr2_-_43266680 0.10 ENST00000425212.1
ENST00000422351.1
ENST00000449766.1
AC016735.2
AC016735.2
chr2_+_68962014 0.10 ENST00000467265.1
ARHGAP25
Rho GTPase activating protein 25
chr18_-_51750948 0.10 ENST00000583046.1
ENST00000398398.2
MBD2
methyl-CpG binding domain protein 2
chr4_+_71091786 0.10 ENST00000317987.5
FDCSP
follicular dendritic cell secreted protein
chr9_-_26947453 0.10 ENST00000397292.3
PLAA
phospholipase A2-activating protein
chr10_-_4285923 0.10 ENST00000418372.1
ENST00000608792.1
LINC00702
long intergenic non-protein coding RNA 702
chr8_-_116504448 0.10 ENST00000518018.1
TRPS1
trichorhinophalangeal syndrome I
chr20_+_30697298 0.09 ENST00000398022.2
TM9SF4
transmembrane 9 superfamily protein member 4
chr8_-_57123815 0.09 ENST00000316981.3
ENST00000423799.2
ENST00000429357.2
PLAG1
pleiomorphic adenoma gene 1
chr12_+_59989918 0.09 ENST00000547379.1
ENST00000549465.1
SLC16A7
solute carrier family 16 (monocarboxylate transporter), member 7
chr18_+_56806701 0.09 ENST00000587834.1
SEC11C
SEC11 homolog C (S. cerevisiae)
chr1_+_225600404 0.09 ENST00000366845.2
AC092811.1
AC092811.1
chr12_+_75784850 0.09 ENST00000550916.1
ENST00000435775.1
ENST00000378689.2
ENST00000378692.3
ENST00000320460.4
ENST00000547164.1
GLIPR1L2
GLI pathogenesis-related 1 like 2
chr2_-_37068530 0.09 ENST00000593798.1
AC007382.1
Uncharacterized protein
chr16_-_66583994 0.09 ENST00000564917.1
TK2
thymidine kinase 2, mitochondrial
chr6_-_29527702 0.09 ENST00000377050.4
UBD
ubiquitin D
chrX_-_52827141 0.09 ENST00000375511.3
SPANXN5
SPANX family, member N5
chr6_-_10415470 0.09 ENST00000379604.2
ENST00000379613.3
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr4_-_76944621 0.09 ENST00000306602.1
CXCL10
chemokine (C-X-C motif) ligand 10
chr17_+_48823896 0.09 ENST00000511974.1
LUC7L3
LUC7-like 3 (S. cerevisiae)
chr19_-_44388116 0.08 ENST00000587539.1
ZNF404
zinc finger protein 404
chr14_-_45252031 0.08 ENST00000556405.1
RP11-398E10.1
RP11-398E10.1
chrX_+_55744166 0.08 ENST00000374941.4
ENST00000414239.1
RRAGB
Ras-related GTP binding B
chr5_-_125930929 0.08 ENST00000553117.1
ENST00000447989.2
ENST00000409134.3
ALDH7A1
aldehyde dehydrogenase 7 family, member A1
chr14_+_102276192 0.08 ENST00000557714.1
PPP2R5C
protein phosphatase 2, regulatory subunit B', gamma
chr4_+_186990298 0.08 ENST00000296795.3
ENST00000513189.1
TLR3
toll-like receptor 3
chr7_-_101272576 0.08 ENST00000223167.4
MYL10
myosin, light chain 10, regulatory
chr1_+_15668240 0.08 ENST00000444385.1
FHAD1
forkhead-associated (FHA) phosphopeptide binding domain 1
chr14_-_104387831 0.08 ENST00000557040.1
ENST00000414262.2
ENST00000555030.1
ENST00000554713.1
ENST00000553430.1
C14orf2
chromosome 14 open reading frame 2
chr9_+_22646189 0.08 ENST00000436786.1
RP11-399D6.2
RP11-399D6.2
chr12_+_26348429 0.08 ENST00000242729.2
SSPN
sarcospan
chr5_+_36606700 0.08 ENST00000416645.2
SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr12_-_112614506 0.08 ENST00000548588.2
HECTD4
HECT domain containing E3 ubiquitin protein ligase 4
chr4_+_75174204 0.08 ENST00000332112.4
ENST00000514968.1
ENST00000503098.1
ENST00000502358.1
ENST00000509145.1
ENST00000505212.1
EPGN
epithelial mitogen
chrX_+_107288280 0.08 ENST00000458383.1
VSIG1
V-set and immunoglobulin domain containing 1
chr6_-_112115074 0.08 ENST00000368667.2
FYN
FYN oncogene related to SRC, FGR, YES
chr19_-_37663332 0.07 ENST00000392157.2
ZNF585A
zinc finger protein 585A
chr5_-_176889381 0.07 ENST00000393563.4
ENST00000512501.1
DBN1
drebrin 1
chr10_+_91152303 0.07 ENST00000371804.3
IFIT1
interferon-induced protein with tetratricopeptide repeats 1
chr10_-_50396407 0.07 ENST00000374153.2
ENST00000374151.3
C10orf128
chromosome 10 open reading frame 128
chr9_-_28670283 0.07 ENST00000379992.2
LINGO2
leucine rich repeat and Ig domain containing 2
chr15_+_84115868 0.07 ENST00000427482.2
SH3GL3
SH3-domain GRB2-like 3
chr17_+_74463650 0.07 ENST00000392492.3
AANAT
aralkylamine N-acetyltransferase
chr3_+_45927994 0.07 ENST00000357632.2
ENST00000395963.2
CCR9
chemokine (C-C motif) receptor 9
chr12_+_8309630 0.07 ENST00000396570.3
ZNF705A
zinc finger protein 705A
chr18_+_46065393 0.07 ENST00000256413.3
CTIF
CBP80/20-dependent translation initiation factor
chr13_-_74993252 0.07 ENST00000325811.1
AL355390.1
Uncharacterized protein
chr1_+_78383813 0.07 ENST00000342754.5
NEXN
nexilin (F actin binding protein)
chr19_-_58326267 0.07 ENST00000391701.1
ZNF552
zinc finger protein 552
chr3_-_122233723 0.07 ENST00000493510.1
ENST00000344337.6
ENST00000476916.1
ENST00000465882.1
KPNA1
karyopherin alpha 1 (importin alpha 5)
chrX_-_77225135 0.07 ENST00000458128.1
PGAM4
phosphoglycerate mutase family member 4
chr9_+_71986182 0.06 ENST00000303068.7
FAM189A2
family with sequence similarity 189, member A2
chr18_-_51751132 0.06 ENST00000256429.3
MBD2
methyl-CpG binding domain protein 2
chr7_+_13141097 0.06 ENST00000411542.1
AC011288.2
AC011288.2
chr1_+_12806141 0.06 ENST00000288048.5
C1orf158
chromosome 1 open reading frame 158

Network of associatons between targets according to the STRING database.

First level regulatory network of OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0002416 IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor(GO:0002416)
0.3 1.1 GO:0060166 olfactory pit development(GO:0060166)
0.2 0.6 GO:0060489 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.2 1.2 GO:0071279 cellular response to cobalt ion(GO:0071279)
0.2 0.5 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
0.1 0.4 GO:1902173 negative regulation of keratinocyte apoptotic process(GO:1902173)
0.1 0.9 GO:0010133 proline catabolic process to glutamate(GO:0010133)
0.1 1.9 GO:0042420 dopamine catabolic process(GO:0042420)
0.1 0.3 GO:0031247 actin rod assembly(GO:0031247)
0.1 0.7 GO:1903575 cornified envelope assembly(GO:1903575)
0.1 0.6 GO:0071461 cellular response to redox state(GO:0071461)
0.1 2.5 GO:0046597 negative regulation of viral entry into host cell(GO:0046597)
0.1 0.3 GO:0010983 positive regulation of high-density lipoprotein particle clearance(GO:0010983)
0.1 0.2 GO:0070105 positive regulation of interleukin-6-mediated signaling pathway(GO:0070105)
0.1 1.1 GO:0042354 fucose catabolic process(GO:0019317) L-fucose metabolic process(GO:0042354) L-fucose catabolic process(GO:0042355)
0.1 1.0 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.1 0.5 GO:1900623 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.1 0.3 GO:0046092 deoxycytidine metabolic process(GO:0046092)
0.1 0.6 GO:0045040 protein import into mitochondrial outer membrane(GO:0045040)
0.0 0.1 GO:0000454 snoRNA guided rRNA pseudouridine synthesis(GO:0000454)
0.0 1.1 GO:0071481 cellular response to X-ray(GO:0071481)
0.0 0.2 GO:0002304 gamma-delta intraepithelial T cell differentiation(GO:0002304) CD8-positive, gamma-delta intraepithelial T cell differentiation(GO:0002305)
0.0 0.1 GO:0050712 negative regulation of interleukin-1 alpha production(GO:0032690) negative regulation of interleukin-1 alpha secretion(GO:0050712)
0.0 0.2 GO:0038172 interleukin-33-mediated signaling pathway(GO:0038172)
0.0 0.6 GO:0006068 ethanol catabolic process(GO:0006068)
0.0 0.2 GO:0032571 response to vitamin K(GO:0032571) regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209) bone regeneration(GO:1990523)
0.0 1.0 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 0.2 GO:1905068 positive regulation of ephrin receptor signaling pathway(GO:1901189) positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068)
0.0 0.3 GO:0071896 protein localization to adherens junction(GO:0071896)
0.0 0.4 GO:0043249 erythrocyte maturation(GO:0043249)
0.0 0.1 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.0 0.1 GO:0042357 thiamine diphosphate metabolic process(GO:0042357)
0.0 0.1 GO:0030186 melatonin metabolic process(GO:0030186) melatonin biosynthetic process(GO:0030187)
0.0 0.1 GO:0090076 relaxation of skeletal muscle(GO:0090076)
0.0 0.3 GO:0046426 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0 0.2 GO:1990253 cellular response to leucine starvation(GO:1990253)
0.0 0.1 GO:0031455 glycine betaine biosynthetic process from choline(GO:0019285) glycine betaine metabolic process(GO:0031455) glycine betaine biosynthetic process(GO:0031456)
0.0 0.1 GO:0034344 type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344) positive regulation of interferon-alpha biosynthetic process(GO:0045356)
0.0 0.1 GO:0043553 vascular endothelial growth factor receptor-2 signaling pathway(GO:0036324) negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.0 0.2 GO:0046952 ketone body catabolic process(GO:0046952)
0.0 0.2 GO:1901529 positive regulation of anion channel activity(GO:1901529)
0.0 0.1 GO:0014886 transition between slow and fast fiber(GO:0014886)
0.0 0.1 GO:0051097 negative regulation of helicase activity(GO:0051097)
0.0 0.1 GO:0003409 optic cup structural organization(GO:0003409) oculomotor nerve morphogenesis(GO:0021622) oculomotor nerve formation(GO:0021623)
0.0 0.1 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
0.0 0.0 GO:0002476 antigen processing and presentation of endogenous peptide antigen via MHC class Ib(GO:0002476)
0.0 0.2 GO:0097475 motor neuron migration(GO:0097475)
0.0 0.3 GO:0097264 self proteolysis(GO:0097264)
0.0 0.3 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.0 0.9 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.0 0.1 GO:0070777 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0 0.2 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.0 0.1 GO:0010643 cell communication by chemical coupling(GO:0010643)
0.0 0.1 GO:0018406 protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.0 0.1 GO:1901475 pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475)
0.0 0.1 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.0 0.1 GO:2000521 negative regulation of immunological synapse formation(GO:2000521)
0.0 0.2 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741)
0.0 0.5 GO:1900087 positive regulation of G1/S transition of mitotic cell cycle(GO:1900087)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0060187 cell pole(GO:0060187)
0.1 1.1 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.1 0.4 GO:0042585 germinal vesicle(GO:0042585)
0.1 1.0 GO:0005577 fibrinogen complex(GO:0005577)
0.1 0.5 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.1 1.3 GO:0043203 axon hillock(GO:0043203)
0.1 0.6 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 0.2 GO:1990131 Gtr1-Gtr2 GTPase complex(GO:1990131)
0.0 0.9 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 0.1 GO:1990032 parallel fiber(GO:1990032)
0.0 1.0 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.3 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.0 0.3 GO:0002177 manchette(GO:0002177)
0.0 0.9 GO:0043209 myelin sheath(GO:0043209)
0.0 0.2 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0 0.1 GO:0090661 box H/ACA scaRNP complex(GO:0072589) box H/ACA telomerase RNP complex(GO:0090661)
0.0 0.3 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.0 0.2 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.0 0.3 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 2.7 GO:0031902 late endosome membrane(GO:0031902)
0.0 0.9 GO:0015030 Cajal body(GO:0015030)
0.0 0.2 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 0.1 GO:0005787 signal peptidase complex(GO:0005787)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0004657 proline dehydrogenase activity(GO:0004657)
0.2 1.9 GO:0008131 primary amine oxidase activity(GO:0008131)
0.2 0.9 GO:0019770 IgG receptor activity(GO:0019770)
0.1 0.6 GO:0047894 flavonol 3-sulfotransferase activity(GO:0047894) steroid sulfotransferase activity(GO:0050294)
0.1 1.1 GO:0070324 thyroid hormone binding(GO:0070324)
0.1 0.2 GO:0002113 interleukin-33 binding(GO:0002113)
0.1 0.3 GO:0008281 sulfonylurea receptor activity(GO:0008281)
0.1 1.1 GO:0008417 fucosyltransferase activity(GO:0008417)
0.1 0.5 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
0.1 0.2 GO:0031783 corticotropin hormone receptor binding(GO:0031780) type 5 melanocortin receptor binding(GO:0031783)
0.0 0.3 GO:0004797 thymidine kinase activity(GO:0004797)
0.0 0.6 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0 0.6 GO:0015266 protein channel activity(GO:0015266)
0.0 0.2 GO:0008260 3-oxoacid CoA-transferase activity(GO:0008260)
0.0 0.5 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0 0.2 GO:0090554 phosphatidylcholine-translocating ATPase activity(GO:0090554)
0.0 0.1 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.0 0.2 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0 0.2 GO:0046790 virion binding(GO:0046790)
0.0 0.1 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.0 0.1 GO:0004910 interleukin-1, Type II, blocking receptor activity(GO:0004910)
0.0 0.3 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.0 0.1 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.0 0.1 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.0 0.1 GO:0070728 leucine binding(GO:0070728)
0.0 0.1 GO:0004060 arylamine N-acetyltransferase activity(GO:0004060)
0.0 0.1 GO:0003998 acylphosphatase activity(GO:0003998)
0.0 0.1 GO:0046538 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.0 0.2 GO:0003696 satellite DNA binding(GO:0003696)
0.0 0.1 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
0.0 0.1 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.0 0.6 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.3 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 1.7 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.1 GO:0019863 IgE binding(GO:0019863)
0.0 0.2 GO:0000150 recombinase activity(GO:0000150)
0.0 0.2 GO:0034485 phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity(GO:0034485)
0.0 0.1 GO:0016778 diphosphotransferase activity(GO:0016778)
0.0 0.1 GO:0042610 CD8 receptor binding(GO:0042610)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.1 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.0 1.2 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.0 0.5 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 1.0 NABA COLLAGENS Genes encoding collagen proteins

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.9 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.0 1.0 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.0 0.4 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.0 2.7 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.4 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.5 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.6 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 1.0 REACTOME G1 PHASE Genes involved in G1 Phase
0.0 1.0 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation