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SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for PAX1_PAX9

Z-value: 0.88

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Transcription factors associated with PAX1_PAX9

Gene Symbol Gene ID Gene Info
PAX1
ENSG00000125813.9 paired box 1
PAX9
ENSG00000198807.8 paired box 9

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PAX9hg19_v2_chr14_+_37131058_37131139-0.926.7e-09Click!
PAX1hg19_v2_chr20_+_21686290_21686311-0.058.5e-01Click!

Activity profile of PAX1_PAX9 motif

Sorted Z-values of PAX1_PAX9 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chrX_-_153707545 3.88 ENST00000357360.4
LAGE3
L antigen family, member 3
chr4_+_123747834 3.87 ENST00000264498.3
FGF2
fibroblast growth factor 2 (basic)
chr4_+_123747979 3.42 ENST00000608478.1
FGF2
fibroblast growth factor 2 (basic)
chr5_+_133842243 3.26 ENST00000515627.2
AC005355.2
AC005355.2
chrX_-_153707246 3.10 ENST00000407062.1
LAGE3
L antigen family, member 3
chr11_-_67397371 2.93 ENST00000376693.2
ENST00000301490.4
NUDT8
nudix (nucleoside diphosphate linked moiety X)-type motif 8
chr5_-_133747551 2.65 ENST00000395009.3
CDKN2AIPNL
CDKN2A interacting protein N-terminal like
chr8_-_125384927 2.21 ENST00000297632.6
TMEM65
transmembrane protein 65
chr8_-_23282797 2.21 ENST00000524144.1
LOXL2
lysyl oxidase-like 2
chr4_+_75230853 2.17 ENST00000244869.2
EREG
epiregulin
chr8_-_23282820 2.11 ENST00000520871.1
LOXL2
lysyl oxidase-like 2
chr11_+_61522844 1.92 ENST00000265460.5
MYRF
myelin regulatory factor
chr7_-_2349579 1.67 ENST00000435060.1
SNX8
sorting nexin 8
chr5_-_133747589 1.62 ENST00000458198.2
CDKN2AIPNL
CDKN2A interacting protein N-terminal like
chr9_-_131418944 1.50 ENST00000419989.1
ENST00000451652.1
ENST00000372715.2
WDR34
WD repeat domain 34
chr8_-_23261589 1.44 ENST00000524168.1
ENST00000523833.2
ENST00000519243.1
ENST00000389131.3
LOXL2
lysyl oxidase-like 2
chr10_+_30723105 1.29 ENST00000375322.2
MAP3K8
mitogen-activated protein kinase kinase kinase 8
chr2_+_207630081 1.02 ENST00000236980.6
ENST00000418289.1
ENST00000402774.3
ENST00000403094.3
FASTKD2
FAST kinase domains 2
chr6_+_159291090 1.01 ENST00000367073.4
ENST00000608817.1
C6orf99
chromosome 6 open reading frame 99
chr7_+_36429409 0.97 ENST00000265748.2
ANLN
anillin, actin binding protein
chr17_+_37356528 0.96 ENST00000225430.4
RPL19
ribosomal protein L19
chr16_+_67197288 0.89 ENST00000264009.8
ENST00000421453.1
HSF4
heat shock transcription factor 4
chr2_-_175712270 0.89 ENST00000295497.7
ENST00000444394.1
CHN1
chimerin 1
chr2_-_175711978 0.86 ENST00000409089.2
CHN1
chimerin 1
chr22_+_39745930 0.85 ENST00000318801.4
ENST00000216155.7
ENST00000406293.3
ENST00000328933.5
SYNGR1
synaptogyrin 1
chr7_+_36429424 0.80 ENST00000396068.2
ANLN
anillin, actin binding protein
chr13_+_21141270 0.79 ENST00000319980.6
ENST00000537103.1
ENST00000389373.3
IFT88
intraflagellar transport 88 homolog (Chlamydomonas)
chr2_-_207630033 0.76 ENST00000449792.1
MDH1B
malate dehydrogenase 1B, NAD (soluble)
chr18_+_39766626 0.73 ENST00000593234.1
ENST00000585627.1
ENST00000591199.1
ENST00000586990.1
ENST00000593051.1
ENST00000593316.1
ENST00000591381.1
ENST00000585639.1
ENST00000589068.1
LINC00907
long intergenic non-protein coding RNA 907
chr2_-_207629997 0.72 ENST00000454776.2
MDH1B
malate dehydrogenase 1B, NAD (soluble)
chr17_+_37356586 0.69 ENST00000579260.1
ENST00000582193.1
RPL19
ribosomal protein L19
chr19_-_40791211 0.69 ENST00000579047.1
AKT2
v-akt murine thymoma viral oncogene homolog 2
chr17_+_37356555 0.67 ENST00000579374.1
RPL19
ribosomal protein L19
chr15_-_31523036 0.67 ENST00000559094.1
ENST00000558388.2
RP11-16E12.2
RP11-16E12.2
chr13_+_21141208 0.59 ENST00000351808.5
IFT88
intraflagellar transport 88 homolog (Chlamydomonas)
chr15_+_63569785 0.59 ENST00000380343.4
ENST00000560353.1
APH1B
APH1B gamma secretase subunit
chr19_-_18995029 0.58 ENST00000596048.1
CERS1
ceramide synthase 1
chr2_+_234160217 0.56 ENST00000392017.4
ENST00000347464.5
ENST00000444735.1
ENST00000373525.5
ENST00000419681.1
ATG16L1
autophagy related 16-like 1 (S. cerevisiae)
chr17_+_39968926 0.56 ENST00000585664.1
ENST00000585922.1
ENST00000429461.1
FKBP10
FK506 binding protein 10, 65 kDa
chr14_+_102196739 0.55 ENST00000556973.1
RP11-796G6.2
Uncharacterized protein
chr6_+_159290917 0.48 ENST00000367072.1
C6orf99
chromosome 6 open reading frame 99
chr17_-_7137582 0.46 ENST00000575756.1
ENST00000575458.1
DVL2
dishevelled segment polarity protein 2
chr1_+_213031570 0.46 ENST00000366971.4
FLVCR1
feline leukemia virus subgroup C cellular receptor 1
chr17_+_76374714 0.44 ENST00000262764.6
ENST00000589689.1
ENST00000329897.7
ENST00000592043.1
ENST00000587356.1
PGS1
phosphatidylglycerophosphate synthase 1
chr17_-_39968855 0.43 ENST00000355468.3
ENST00000590496.1
LEPREL4
leprecan-like 4
chr9_-_104249400 0.41 ENST00000374848.3
TMEM246
transmembrane protein 246
chr19_-_39104556 0.37 ENST00000423454.2
MAP4K1
mitogen-activated protein kinase kinase kinase kinase 1
chr15_+_63569731 0.37 ENST00000261879.5
APH1B
APH1B gamma secretase subunit
chr11_+_63870660 0.35 ENST00000246841.3
FLRT1
fibronectin leucine rich transmembrane protein 1
chr4_-_171011084 0.29 ENST00000337664.4
AADAT
aminoadipate aminotransferase
chr7_-_19157248 0.29 ENST00000242261.5
TWIST1
twist family bHLH transcription factor 1
chr12_-_122658746 0.29 ENST00000377035.1
IL31
interleukin 31
chr14_+_64854958 0.28 ENST00000555709.2
ENST00000554739.1
ENST00000554768.1
ENST00000216605.8
MTHFD1
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
chr4_-_171011323 0.27 ENST00000509167.1
ENST00000353187.2
ENST00000507375.1
ENST00000515480.1
AADAT
aminoadipate aminotransferase
chr17_+_39969183 0.24 ENST00000321562.4
FKBP10
FK506 binding protein 10, 65 kDa
chr12_+_57828521 0.24 ENST00000309668.2
INHBC
inhibin, beta C
chr14_+_24540046 0.20 ENST00000397016.2
ENST00000537691.1
ENST00000560356.1
ENST00000558450.1
CPNE6
copine VI (neuronal)
chr19_-_40791302 0.20 ENST00000392038.2
ENST00000578123.1
AKT2
v-akt murine thymoma viral oncogene homolog 2
chr1_-_204165610 0.19 ENST00000367194.4
KISS1
KiSS-1 metastasis-suppressor
chrX_+_148622513 0.19 ENST00000393985.3
ENST00000423421.1
ENST00000423540.2
ENST00000434353.2
ENST00000514208.1
CXorf40A
chromosome X open reading frame 40A
chr19_-_409134 0.16 ENST00000332235.6
C2CD4C
C2 calcium-dependent domain containing 4C
chr19_-_52148798 0.15 ENST00000534261.2
SIGLEC5
sialic acid binding Ig-like lectin 5
chr3_-_25824925 0.13 ENST00000396649.3
ENST00000428257.1
ENST00000280700.5
NGLY1
N-glycanase 1
chr1_+_45140360 0.13 ENST00000418644.1
ENST00000458657.2
ENST00000441519.1
ENST00000535358.1
ENST00000445071.1
C1orf228
chromosome 1 open reading frame 228
chr4_-_163085141 0.13 ENST00000427802.2
ENST00000306100.5
FSTL5
follistatin-like 5
chr14_+_39703112 0.12 ENST00000555143.1
ENST00000280082.3
MIA2
melanoma inhibitory activity 2
chr2_+_234160340 0.12 ENST00000417017.1
ENST00000392020.4
ENST00000392018.1
ATG16L1
autophagy related 16-like 1 (S. cerevisiae)
chr1_+_26759295 0.11 ENST00000430232.1
DHDDS
dehydrodolichyl diphosphate synthase
chr6_-_170893742 0.10 ENST00000443345.2
ENST00000541970.1
PDCD2
programmed cell death 2
chr9_-_21142144 0.09 ENST00000380229.2
IFNW1
interferon, omega 1
chr3_+_31574189 0.09 ENST00000295770.2
STT3B
STT3B, subunit of the oligosaccharyltransferase complex (catalytic)
chr17_-_39968406 0.09 ENST00000393928.1
LEPREL4
leprecan-like 4
chr3_+_15247686 0.07 ENST00000253693.2
CAPN7
calpain 7
chr10_+_82297658 0.06 ENST00000339284.2
SH2D4B
SH2 domain containing 4B
chr8_-_121824374 0.06 ENST00000517992.1
SNTB1
syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
chr12_+_58138800 0.06 ENST00000547992.1
ENST00000552816.1
ENST00000547472.1
TSPAN31
tetraspanin 31
chr6_-_170893669 0.06 ENST00000392090.2
ENST00000542896.1
ENST00000453163.2
ENST00000537445.1
PDCD2
programmed cell death 2
chr6_+_3118926 0.05 ENST00000380379.5
BPHL
biphenyl hydrolase-like (serine hydrolase)
chr7_-_112758665 0.05 ENST00000397764.3
LINC00998
long intergenic non-protein coding RNA 998
chr3_-_25824872 0.03 ENST00000308710.5
NGLY1
N-glycanase 1
chr1_-_213031418 0.01 ENST00000356684.3
ENST00000426161.1
ENST00000424044.1
FLVCR1-AS1
FLVCR1 antisense RNA 1 (head to head)

Network of associatons between targets according to the STRING database.

First level regulatory network of PAX1_PAX9

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 7.3 GO:0042660 positive regulation of cell fate specification(GO:0042660)
1.4 5.8 GO:0018277 protein deamination(GO:0018277)
0.6 1.8 GO:0031106 septin ring assembly(GO:0000921) septin ring organization(GO:0031106)
0.3 2.2 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.2 1.0 GO:1902775 mitochondrial large ribosomal subunit assembly(GO:1902775)
0.2 0.8 GO:0000412 histone peptidyl-prolyl isomerization(GO:0000412)
0.2 0.6 GO:0072720 cellular response to mycotoxin(GO:0036146) response to dithiothreitol(GO:0072720)
0.2 1.9 GO:0032286 central nervous system myelin maintenance(GO:0032286)
0.1 0.9 GO:0097473 cellular response to high light intensity(GO:0071486) retinal rod cell apoptotic process(GO:0097473)
0.1 0.5 GO:0022007 neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007)
0.1 0.7 GO:0044034 negative stranded viral RNA replication(GO:0039689) multi-organism biosynthetic process(GO:0044034)
0.1 0.3 GO:2000276 negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359) negative regulation of oxidative phosphorylation uncoupler activity(GO:2000276)
0.1 0.6 GO:0033512 L-lysine catabolic process to acetyl-CoA via saccharopine(GO:0033512) L-kynurenine metabolic process(GO:0097052)
0.1 1.7 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.1 1.5 GO:0006108 malate metabolic process(GO:0006108)
0.1 0.3 GO:0009257 10-formyltetrahydrofolate biosynthetic process(GO:0009257)
0.0 0.2 GO:0033686 positive regulation of luteinizing hormone secretion(GO:0033686)
0.0 2.9 GO:0035735 intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.0 2.3 GO:0097421 liver regeneration(GO:0097421)
0.0 7.0 GO:0008033 tRNA processing(GO:0008033)
0.0 0.9 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0 1.0 GO:0007220 Notch receptor processing(GO:0007220)
0.0 1.7 GO:0008045 motor neuron axon guidance(GO:0008045)
0.0 0.9 GO:0033169 histone H3-K9 demethylation(GO:0033169)
0.0 0.4 GO:0032049 cardiolipin biosynthetic process(GO:0032049)
0.0 0.5 GO:0043249 erythrocyte maturation(GO:0043249)
0.0 0.1 GO:0043686 co-translational protein modification(GO:0043686)
0.0 1.3 GO:0000186 activation of MAPKK activity(GO:0000186)
0.0 2.2 GO:1903779 regulation of cardiac conduction(GO:1903779)
0.0 0.4 GO:0000185 activation of MAPKKK activity(GO:0000185)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 7.0 GO:0000408 EKC/KEOPS complex(GO:0000408)
0.3 1.8 GO:0005826 actomyosin contractile ring(GO:0005826)
0.1 1.0 GO:0070765 gamma-secretase complex(GO:0070765)
0.0 1.7 GO:0030904 retromer complex(GO:0030904)
0.0 1.4 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 1.5 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 5.8 GO:0005604 basement membrane(GO:0005604)
0.0 0.7 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.0 2.2 GO:0014704 intercalated disc(GO:0014704)
0.0 1.0 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 5.8 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.6 2.3 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
0.3 7.6 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.2 0.6 GO:0047536 2-aminoadipate transaminase activity(GO:0047536)
0.2 1.5 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
0.1 0.3 GO:0004487 methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487)
0.1 1.5 GO:0045504 dynein heavy chain binding(GO:0045504)
0.1 0.2 GO:0000224 peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity(GO:0000224)
0.0 0.4 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.0 0.6 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.0 2.2 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 1.3 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.5 GO:0015232 heme transporter activity(GO:0015232)
0.0 0.8 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 0.1 GO:0090541 MIT domain binding(GO:0090541)
0.0 0.4 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 1.0 GO:0019843 rRNA binding(GO:0019843)
0.0 1.7 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.1 GO:0005132 type I interferon receptor binding(GO:0005132)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 7.3 PID GLYPICAN 1PATHWAY Glypican 1 network
0.1 2.2 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.1 1.7 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 1.0 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.0 0.9 SA TRKA RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0 0.5 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin
0.0 1.7 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.0 1.4 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 3.4 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 7.3 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.1 0.9 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.1 1.0 REACTOME REGULATED PROTEOLYSIS OF P75NTR Genes involved in Regulated proteolysis of p75NTR
0.0 2.2 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.0 1.3 REACTOME CD28 DEPENDENT PI3K AKT SIGNALING Genes involved in CD28 dependent PI3K/Akt signaling
0.0 0.2 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.0 0.5 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.0 0.5 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo