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SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for PBX2

Z-value: 0.27

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Transcription factors associated with PBX2

Gene Symbol Gene ID Gene Info
PBX2
ENSG00000204304.7 PBX homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PBX2hg19_v2_chr6_-_32157947_321579920.912.3e-08Click!

Activity profile of PBX2 motif

Sorted Z-values of PBX2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr12_-_28124903 1.79 ENST00000395872.1
ENST00000354417.3
ENST00000201015.4
PTHLH
parathyroid hormone-like hormone
chr12_-_28125638 1.72 ENST00000545234.1
PTHLH
parathyroid hormone-like hormone
chr2_+_234104079 0.78 ENST00000417661.1
INPP5D
inositol polyphosphate-5-phosphatase, 145kDa
chr2_-_31440377 0.69 ENST00000444918.2
ENST00000403897.3
CAPN14
calpain 14
chr2_+_12857043 0.63 ENST00000381465.2
TRIB2
tribbles pseudokinase 2
chrM_+_12331 0.59 ENST00000361567.2
MT-ND5
mitochondrially encoded NADH dehydrogenase 5
chr2_+_12857015 0.58 ENST00000155926.4
TRIB2
tribbles pseudokinase 2
chr11_-_111794446 0.56 ENST00000527950.1
CRYAB
crystallin, alpha B
chr14_-_23624511 0.47 ENST00000529705.2
SLC7A8
solute carrier family 7 (amino acid transporter light chain, L system), member 8
chr17_+_7758374 0.45 ENST00000301599.6
ENST00000574668.1
TMEM88
transmembrane protein 88
chr2_+_234602305 0.35 ENST00000406651.1
UGT1A6
UDP glucuronosyltransferase 1 family, polypeptide A6
chr2_+_234601512 0.30 ENST00000305139.6
UGT1A6
UDP glucuronosyltransferase 1 family, polypeptide A6
chr10_-_45474237 0.25 ENST00000448778.1
ENST00000298295.3
C10orf10
chromosome 10 open reading frame 10
chr1_+_101702417 0.25 ENST00000305352.6
S1PR1
sphingosine-1-phosphate receptor 1
chr11_+_68228186 0.21 ENST00000393799.2
ENST00000393800.2
ENST00000528635.1
ENST00000533127.1
ENST00000529907.1
ENST00000529344.1
ENST00000534534.1
ENST00000524845.1
ENST00000265637.4
ENST00000524904.1
ENST00000393801.3
ENST00000265636.5
ENST00000529710.1
PPP6R3
protein phosphatase 6, regulatory subunit 3
chr3_-_47932759 0.20 ENST00000441748.2
ENST00000335271.5
MAP4
microtubule-associated protein 4
chr2_+_113033164 0.20 ENST00000409871.1
ENST00000343936.4
ZC3H6
zinc finger CCCH-type containing 6
chr11_-_2162162 0.17 ENST00000381389.1
IGF2
insulin-like growth factor 2 (somatomedin A)
chrX_+_46696372 0.16 ENST00000218340.3
RP2
retinitis pigmentosa 2 (X-linked recessive)
chr7_+_134528635 0.15 ENST00000445569.2
CALD1
caldesmon 1
chr14_+_58765103 0.14 ENST00000355431.3
ENST00000348476.3
ENST00000395168.3
ARID4A
AT rich interactive domain 4A (RBP1-like)
chr11_+_69455855 0.13 ENST00000227507.2
ENST00000536559.1
CCND1
cyclin D1
chr1_+_62417957 0.13 ENST00000307297.7
ENST00000543708.1
INADL
InaD-like (Drosophila)
chr12_+_53835383 0.13 ENST00000429243.2
PRR13
proline rich 13
chr7_-_112727774 0.13 ENST00000297146.3
ENST00000501255.2
GPR85
G protein-coupled receptor 85
chr12_+_53835425 0.12 ENST00000549924.1
PRR13
proline rich 13
chr4_-_100065440 0.12 ENST00000508393.1
ENST00000265512.7
ADH4
alcohol dehydrogenase 4 (class II), pi polypeptide
chr12_+_53835539 0.11 ENST00000547368.1
ENST00000379786.4
ENST00000551945.1
PRR13
proline rich 13
chr13_-_107220455 0.10 ENST00000400198.3
ARGLU1
arginine and glutamate rich 1
chr10_+_47894572 0.10 ENST00000355876.5
FAM21B
family with sequence similarity 21, member B
chr1_-_115323245 0.10 ENST00000060969.5
ENST00000369528.5
SIKE1
suppressor of IKBKE 1
chr5_-_39462390 0.09 ENST00000511792.1
DAB2
Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
chr18_-_72920372 0.08 ENST00000581620.1
ENST00000582437.1
ZADH2
zinc binding alcohol dehydrogenase domain containing 2
chr7_-_33140498 0.08 ENST00000448915.1
RP9
retinitis pigmentosa 9 (autosomal dominant)
chr14_+_58765305 0.07 ENST00000445108.1
ARID4A
AT rich interactive domain 4A (RBP1-like)
chr3_-_129158676 0.06 ENST00000393278.2
MBD4
methyl-CpG binding domain protein 4
chr3_-_112013071 0.06 ENST00000487372.1
ENST00000486574.1
ENST00000305815.5
SLC9C1
solute carrier family 9, subfamily C (Na+-transporting carboxylic acid decarboxylase), member 1
chr3_+_188889737 0.06 ENST00000345063.3
TPRG1
tumor protein p63 regulated 1
chr2_+_204732487 0.05 ENST00000302823.3
CTLA4
cytotoxic T-lymphocyte-associated protein 4
chr14_+_38033252 0.04 ENST00000554829.1
RP11-356O9.1
RP11-356O9.1
chr16_-_11492366 0.03 ENST00000595360.1
CTD-3088G3.8
Protein LOC388210
chr6_+_53976211 0.02 ENST00000503951.1
MLIP
muscular LMNA-interacting protein
chr4_-_100065419 0.01 ENST00000504125.1
ENST00000505590.1
ADH4
alcohol dehydrogenase 4 (class II), pi polypeptide
chr3_+_120626919 0.01 ENST00000273666.6
ENST00000471454.1
ENST00000472879.1
ENST00000497029.1
ENST00000492541.1
STXBP5L
syntaxin binding protein 5-like
chr4_-_100065389 0.00 ENST00000512499.1
ADH4
alcohol dehydrogenase 4 (class II), pi polypeptide

Network of associatons between targets according to the STRING database.

First level regulatory network of PBX2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0045081 negative regulation of interleukin-10 biosynthetic process(GO:0045081)
0.2 0.8 GO:0045658 regulation of neutrophil differentiation(GO:0045658) negative regulation of neutrophil differentiation(GO:0045659)
0.1 3.5 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)
0.1 0.2 GO:0003245 cardiac muscle tissue growth involved in heart morphogenesis(GO:0003245)
0.1 0.2 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.1 0.7 GO:0052697 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.0 0.2 GO:0097368 establishment of Sertoli cell barrier(GO:0097368)
0.0 0.2 GO:0051012 microtubule sliding(GO:0051012)
0.0 0.6 GO:0007021 tubulin complex assembly(GO:0007021)
0.0 0.2 GO:2000467 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028) positive regulation of glycogen (starch) synthase activity(GO:2000467)
0.0 0.1 GO:0035026 leading edge cell differentiation(GO:0035026)
0.0 0.5 GO:0015695 organic cation transport(GO:0015695)
0.0 0.0 GO:0045590 negative regulation of regulatory T cell differentiation(GO:0045590)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:1990075 periciliary membrane compartment(GO:1990075)
0.0 0.6 GO:0097512 cardiac myofibril(GO:0097512)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.1 3.5 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.1 1.2 GO:0055106 ubiquitin-protein transferase regulator activity(GO:0055106)
0.0 0.1 GO:0019115 benzaldehyde dehydrogenase activity(GO:0019115)
0.0 0.5 GO:0019534 toxin transporter activity(GO:0019534)
0.0 0.6 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.2 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.0 0.7 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.7 GO:0001972 retinoic acid binding(GO:0001972)
0.0 0.1 GO:0047522 13-prostaglandin reductase activity(GO:0036132) 15-oxoprostaglandin 13-oxidase activity(GO:0047522)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.5 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.8 ST INTERLEUKIN 4 PATHWAY Interleukin 4 (IL-4) Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 3.5 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.7 REACTOME GLUCURONIDATION Genes involved in Glucuronidation