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SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for PBX2
Z-value: 0.27
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Transcription factors associated with PBX2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PBX2 | hg19_v2_chr6_-_32157947_32157992 | 0.91 | 2.3e-08 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr12_-_28124903 Show fit | 1.79 |
ENST00000395872.1
ENST00000354417.3 ENST00000201015.4 |
parathyroid hormone-like hormone |
|
| chr12_-_28125638 Show fit | 1.72 |
ENST00000545234.1
|
parathyroid hormone-like hormone |
|
| chr2_+_234104079 Show fit | 0.78 |
ENST00000417661.1
|
inositol polyphosphate-5-phosphatase, 145kDa |
|
| chr2_-_31440377 Show fit | 0.69 |
ENST00000444918.2
ENST00000403897.3 |
calpain 14 |
|
| chr2_+_12857043 Show fit | 0.63 |
ENST00000381465.2
|
tribbles pseudokinase 2 |
|
| chrM_+_12331 Show fit | 0.59 |
ENST00000361567.2
|
mitochondrially encoded NADH dehydrogenase 5 |
|
| chr2_+_12857015 Show fit | 0.58 |
ENST00000155926.4
|
tribbles pseudokinase 2 |
|
| chr11_-_111794446 Show fit | 0.56 |
ENST00000527950.1
|
crystallin, alpha B |
|
| chr14_-_23624511 Show fit | 0.47 |
ENST00000529705.2
|
solute carrier family 7 (amino acid transporter light chain, L system), member 8 |
|
| chr17_+_7758374 Show fit | 0.45 |
ENST00000301599.6
ENST00000574668.1 |
transmembrane protein 88 |
Network of associatons between targets according to the STRING database.
First level regulatory network of PBX2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.5 | GO:0032331 | negative regulation of chondrocyte differentiation(GO:0032331) |
| 0.4 | 1.2 | GO:0045081 | negative regulation of interleukin-10 biosynthetic process(GO:0045081) |
| 0.2 | 0.8 | GO:0045658 | regulation of neutrophil differentiation(GO:0045658) negative regulation of neutrophil differentiation(GO:0045659) |
| 0.1 | 0.7 | GO:0052697 | flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697) |
| 0.0 | 0.6 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 0.0 | 0.5 | GO:0015695 | organic cation transport(GO:0015695) |
| 0.1 | 0.2 | GO:0003245 | cardiac muscle tissue growth involved in heart morphogenesis(GO:0003245) |
| 0.1 | 0.2 | GO:0007023 | post-chaperonin tubulin folding pathway(GO:0007023) |
| 0.0 | 0.2 | GO:0097368 | establishment of Sertoli cell barrier(GO:0097368) |
| 0.0 | 0.2 | GO:0051012 | microtubule sliding(GO:0051012) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.6 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.0 | 0.2 | GO:1990075 | periciliary membrane compartment(GO:1990075) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.5 | GO:0051428 | peptide hormone receptor binding(GO:0051428) |
| 0.1 | 1.2 | GO:0055106 | ubiquitin-protein transferase regulator activity(GO:0055106) |
| 0.1 | 0.8 | GO:0016314 | phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314) |
| 0.0 | 0.7 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.0 | 0.7 | GO:0001972 | retinoic acid binding(GO:0001972) |
| 0.0 | 0.6 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.0 | 0.5 | GO:0019534 | toxin transporter activity(GO:0019534) |
| 0.0 | 0.2 | GO:0038036 | sphingosine-1-phosphate receptor activity(GO:0038036) |
| 0.0 | 0.1 | GO:0019115 | benzaldehyde dehydrogenase activity(GO:0019115) |
| 0.0 | 0.1 | GO:0047522 | 13-prostaglandin reductase activity(GO:0036132) 15-oxoprostaglandin 13-oxidase activity(GO:0047522) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.5 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.0 | 0.8 | ST INTERLEUKIN 4 PATHWAY | Interleukin 4 (IL-4) Pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.5 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.0 | 0.7 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |