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SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for PITX2

Z-value: 0.49

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Transcription factors associated with PITX2

Gene Symbol Gene ID Gene Info
PITX2
ENSG00000164093.11 paired like homeodomain 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PITX2hg19_v2_chr4_-_111563076_111563172-0.604.8e-03Click!

Activity profile of PITX2 motif

Sorted Z-values of PITX2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_2407754 1.45 ENST00000419816.2
ENST00000378486.3
ENST00000378488.3
ENST00000288766.5
PLCH2
phospholipase C, eta 2
chr3_-_69249863 1.24 ENST00000478263.1
ENST00000462512.1
FRMD4B
FERM domain containing 4B
chr6_-_138893661 0.82 ENST00000427025.2
NHSL1
NHS-like 1
chr6_+_35310391 0.78 ENST00000337400.2
ENST00000311565.4
ENST00000540939.1
PPARD
peroxisome proliferator-activated receptor delta
chr18_-_47017956 0.77 ENST00000584895.1
ENST00000332968.6
ENST00000580210.1
ENST00000579408.1
RPL17-C18orf32
RPL17
RPL17-C18orf32 readthrough
ribosomal protein L17
chr6_+_35310312 0.77 ENST00000448077.2
ENST00000360694.3
ENST00000418635.2
ENST00000444397.1
PPARD
peroxisome proliferator-activated receptor delta
chr9_-_110251836 0.60 ENST00000374672.4
KLF4
Kruppel-like factor 4 (gut)
chrX_-_48931648 0.59 ENST00000376386.3
ENST00000376390.4
PRAF2
PRA1 domain family, member 2
chr4_+_146560245 0.56 ENST00000541599.1
MMAA
methylmalonic aciduria (cobalamin deficiency) cblA type
chr14_+_75988768 0.55 ENST00000286639.6
BATF
basic leucine zipper transcription factor, ATF-like
chr6_+_130339710 0.49 ENST00000526087.1
ENST00000533560.1
ENST00000361794.2
L3MBTL3
l(3)mbt-like 3 (Drosophila)
chr4_+_126237554 0.41 ENST00000394329.3
FAT4
FAT atypical cadherin 4
chrM_+_9207 0.41 ENST00000362079.2
MT-CO3
mitochondrially encoded cytochrome c oxidase III
chr17_-_4643114 0.40 ENST00000293778.6
CXCL16
chemokine (C-X-C motif) ligand 16
chr19_-_46142362 0.34 ENST00000586770.1
ENST00000591721.1
EML2
echinoderm microtubule associated protein like 2
chr21_-_34915084 0.32 ENST00000426819.1
GART
phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
chr16_+_58010339 0.32 ENST00000290871.5
ENST00000441824.2
TEPP
testis, prostate and placenta expressed
chr8_-_42360015 0.32 ENST00000522707.1
SLC20A2
solute carrier family 20 (phosphate transporter), member 2
chr4_-_76912070 0.29 ENST00000395711.4
ENST00000356260.5
SDAD1
SDA1 domain containing 1
chr13_+_73632897 0.29 ENST00000377687.4
KLF5
Kruppel-like factor 5 (intestinal)
chr8_+_123875624 0.28 ENST00000534247.1
ZHX2
zinc fingers and homeoboxes 2
chr11_-_96076334 0.28 ENST00000524717.1
MAML2
mastermind-like 2 (Drosophila)
chr2_+_120770686 0.28 ENST00000331393.4
ENST00000443124.1
EPB41L5
erythrocyte membrane protein band 4.1 like 5
chr14_+_75988851 0.25 ENST00000555504.1
BATF
basic leucine zipper transcription factor, ATF-like
chr10_-_61900762 0.25 ENST00000355288.2
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr17_-_4643161 0.24 ENST00000574412.1
CXCL16
chemokine (C-X-C motif) ligand 16
chr12_+_40787194 0.24 ENST00000425730.2
ENST00000454784.4
MUC19
mucin 19, oligomeric
chr3_+_139062838 0.23 ENST00000310776.4
ENST00000465056.1
ENST00000465373.1
MRPS22
mitochondrial ribosomal protein S22
chr9_+_34458771 0.21 ENST00000437363.1
ENST00000242317.4
DNAI1
dynein, axonemal, intermediate chain 1
chr6_+_46661575 0.20 ENST00000450697.1
TDRD6
tudor domain containing 6
chr7_+_73868439 0.20 ENST00000424337.2
GTF2IRD1
GTF2I repeat domain containing 1
chr16_+_28722684 0.19 ENST00000331666.6
ENST00000395587.1
ENST00000569690.1
ENST00000564243.1
EIF3C
eukaryotic translation initiation factor 3, subunit C
chr16_-_12070468 0.19 ENST00000538896.1
RP11-166B2.1
Putative NPIP-like protein LOC729978
chr10_+_103986085 0.18 ENST00000370005.3
ELOVL3
ELOVL fatty acid elongase 3
chr9_+_34458851 0.16 ENST00000545019.1
DNAI1
dynein, axonemal, intermediate chain 1
chr21_-_34915147 0.16 ENST00000381831.3
ENST00000381839.3
GART
phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
chr4_-_36245561 0.16 ENST00000506189.1
ARAP2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chrX_-_54384425 0.15 ENST00000375169.3
ENST00000354646.2
WNK3
WNK lysine deficient protein kinase 3
chr11_-_36619771 0.15 ENST00000311485.3
ENST00000527033.1
ENST00000532616.1
RAG2
recombination activating gene 2
chr4_-_68620053 0.15 ENST00000420975.2
ENST00000226413.4
GNRHR
gonadotropin-releasing hormone receptor
chr12_+_6949964 0.14 ENST00000541978.1
ENST00000435982.2
GNB3
guanine nucleotide binding protein (G protein), beta polypeptide 3
chr22_-_30234218 0.13 ENST00000307790.3
ENST00000542393.1
ENST00000397771.2
ASCC2
activating signal cointegrator 1 complex subunit 2
chr7_+_73868220 0.12 ENST00000455841.2
GTF2IRD1
GTF2I repeat domain containing 1
chr1_-_31230650 0.11 ENST00000294507.3
LAPTM5
lysosomal protein transmembrane 5
chr17_+_4643300 0.11 ENST00000433935.1
ZMYND15
zinc finger, MYND-type containing 15
chr17_-_46657473 0.11 ENST00000332503.5
HOXB4
homeobox B4
chr2_-_121223697 0.10 ENST00000593290.1
FLJ14816
long intergenic non-protein coding RNA 1101
chr3_+_119421849 0.09 ENST00000273390.5
ENST00000463700.1
MAATS1
MYCBP-associated, testis expressed 1
chr12_+_7941989 0.09 ENST00000229307.4
NANOG
Nanog homeobox
chr1_-_165414414 0.09 ENST00000359842.5
RXRG
retinoid X receptor, gamma
chr9_+_8858102 0.08 ENST00000447950.1
ENST00000430766.1
RP11-75C9.1
RP11-75C9.1
chr11_-_119217365 0.08 ENST00000360167.4
ENST00000555262.1
ENST00000449574.2
ENST00000445041.2
MFRP
C1QTNF5
membrane frizzled-related protein
C1q and tumor necrosis factor related protein 5
chr2_+_201994569 0.07 ENST00000457277.1
CFLAR
CASP8 and FADD-like apoptosis regulator
chr10_-_75193308 0.07 ENST00000299432.2
MSS51
MSS51 mitochondrial translational activator
chr6_-_33297013 0.07 ENST00000453407.1
DAXX
death-domain associated protein
chrX_-_33357558 0.07 ENST00000288447.4
DMD
dystrophin
chr12_-_53189892 0.06 ENST00000309505.3
ENST00000417996.2
KRT3
keratin 3
chr1_-_98515395 0.05 ENST00000424528.2
MIR137HG
MIR137 host gene (non-protein coding)
chr17_+_4643337 0.05 ENST00000592813.1
ZMYND15
zinc finger, MYND-type containing 15
chr4_+_70916119 0.04 ENST00000246896.3
ENST00000511674.1
HTN1
histatin 1
chr13_-_95131923 0.03 ENST00000377028.5
ENST00000446125.1
DCT
dopachrome tautomerase
chr18_-_3880051 0.03 ENST00000584874.1
DLGAP1
discs, large (Drosophila) homolog-associated protein 1
chr1_+_205538165 0.03 ENST00000536357.1
MFSD4
major facilitator superfamily domain containing 4
chr9_+_12693336 0.03 ENST00000381137.2
ENST00000388918.5
TYRP1
tyrosinase-related protein 1
chr6_-_53013620 0.03 ENST00000259803.7
GCM1
glial cells missing homolog 1 (Drosophila)
chr19_-_51893827 0.02 ENST00000574814.1
CTD-2616J11.4
chromosome 19 open reading frame 84
chr9_-_98268883 0.02 ENST00000551630.1
ENST00000548420.1
PTCH1
patched 1
chrX_-_6146876 0.01 ENST00000381095.3
NLGN4X
neuroligin 4, X-linked
chr10_-_49482907 0.01 ENST00000374201.3
ENST00000407470.4
FRMPD2
FERM and PDZ domain containing 2
chr3_+_158787098 0.01 ENST00000397832.2
ENST00000451172.1
ENST00000482126.1
IQCJ
IQ motif containing J
chr19_-_51893782 0.01 ENST00000570516.1
CTD-2616J11.4
chromosome 19 open reading frame 84
chr9_-_8857776 0.01 ENST00000481079.1
PTPRD
protein tyrosine phosphatase, receptor type, D
chr6_-_41673552 0.00 ENST00000419574.1
ENST00000445214.1
TFEB
transcription factor EB

Network of associatons between targets according to the STRING database.

First level regulatory network of PITX2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:2000342 negative regulation of chemokine (C-X-C motif) ligand 2 production(GO:2000342)
0.1 1.5 GO:0043415 positive regulation of skeletal muscle tissue regeneration(GO:0043415)
0.1 0.6 GO:0009236 cobalamin biosynthetic process(GO:0009236)
0.1 0.4 GO:0072137 condensed mesenchymal cell proliferation(GO:0072137)
0.1 0.3 GO:0014886 transition between slow and fast fiber(GO:0014886)
0.1 0.8 GO:0097475 motor neuron migration(GO:0097475)
0.0 0.2 GO:1900827 maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.0 0.5 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.0 0.2 GO:2000686 regulation of rubidium ion transmembrane transporter activity(GO:2000686)
0.0 0.8 GO:0072540 T-helper 17 cell lineage commitment(GO:0072540)
0.0 0.5 GO:0043249 erythrocyte maturation(GO:0043249)
0.0 0.3 GO:0032534 regulation of microvillus assembly(GO:0032534)
0.0 0.6 GO:0010818 T cell chemotaxis(GO:0010818)
0.0 0.3 GO:0000055 ribosomal large subunit export from nucleus(GO:0000055)
0.0 1.2 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.0 0.2 GO:0002331 pre-B cell allelic exclusion(GO:0002331)
0.0 0.1 GO:0097210 response to gonadotropin-releasing hormone(GO:0097210) cellular response to gonadotropin-releasing hormone(GO:0097211)
0.0 0.1 GO:0072737 response to diamide(GO:0072737) cellular response to diamide(GO:0072738)
0.0 0.3 GO:0010968 regulation of microtubule nucleation(GO:0010968)
0.0 0.3 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.0 0.3 GO:0044341 sodium-dependent phosphate transport(GO:0044341)
0.0 0.2 GO:1902416 positive regulation of mRNA binding(GO:1902416)
0.0 0.1 GO:0048539 bone marrow development(GO:0048539)
0.0 0.4 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 0.4 GO:0036158 outer dynein arm assembly(GO:0036158)
0.0 0.2 GO:0019368 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 0.6 GO:0015813 L-glutamate transport(GO:0015813)
0.0 1.5 GO:0043647 inositol phosphate metabolic process(GO:0043647)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0001534 radial spoke(GO:0001534)
0.0 0.4 GO:0036157 outer dynein arm(GO:0036157)
0.0 0.4 GO:0045277 respiratory chain complex IV(GO:0045277)
0.0 0.6 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 0.2 GO:0033391 chromatoid body(GO:0033391)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0004641 phosphoribosylamine-glycine ligase activity(GO:0004637) phosphoribosylformylglycinamidine cyclo-ligase activity(GO:0004641) phosphoribosylglycinamide formyltransferase activity(GO:0004644)
0.1 0.6 GO:0001010 transcription factor activity, sequence-specific DNA binding transcription factor recruiting(GO:0001010)
0.1 1.5 GO:0036041 long-chain fatty acid binding(GO:0036041)
0.0 0.1 GO:0004968 gonadotropin-releasing hormone receptor activity(GO:0004968)
0.0 1.5 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 0.3 GO:0015319 sodium:inorganic phosphate symporter activity(GO:0015319)
0.0 0.1 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.0 0.4 GO:0045504 dynein heavy chain binding(GO:0045504)
0.0 0.6 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.0 0.2 GO:0009922 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0 0.4 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.2 GO:0019869 chloride channel inhibitor activity(GO:0019869)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.6 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 0.5 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 0.1 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.0 0.3 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway