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SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for PLAGL1
Z-value: 4.10
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Transcription factors associated with PLAGL1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PLAGL1 | hg19_v2_chr6_-_144329531_144329546 | -0.47 | 3.4e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of PLAGL1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 39.2 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 0.2 | 27.5 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 1.5 | 19.2 | GO:0043435 | response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376) |
| 0.2 | 17.1 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.3 | 16.0 | GO:0090662 | ATP hydrolysis coupled transmembrane transport(GO:0090662) |
| 0.8 | 14.8 | GO:1901750 | leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750) |
| 0.9 | 13.7 | GO:0000050 | urea cycle(GO:0000050) |
| 0.4 | 13.5 | GO:0042776 | mitochondrial ATP synthesis coupled proton transport(GO:0042776) |
| 0.9 | 13.3 | GO:0032049 | cardiolipin biosynthetic process(GO:0032049) |
| 0.2 | 12.9 | GO:0000413 | protein peptidyl-prolyl isomerization(GO:0000413) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 410.5 | GO:0016021 | integral component of membrane(GO:0016021) |
| 0.1 | 65.3 | GO:0005615 | extracellular space(GO:0005615) |
| 0.3 | 35.4 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.1 | 27.4 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.4 | 21.7 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 0.8 | 21.3 | GO:0042627 | chylomicron(GO:0042627) |
| 2.3 | 20.4 | GO:0035976 | AP1 complex(GO:0035976) |
| 0.2 | 20.1 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.1 | 19.4 | GO:0008021 | synaptic vesicle(GO:0008021) |
| 0.2 | 19.0 | GO:0005747 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 68.3 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.1 | 62.5 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.2 | 23.0 | GO:0003707 | steroid hormone receptor activity(GO:0003707) |
| 0.2 | 22.8 | GO:0005179 | hormone activity(GO:0005179) |
| 0.3 | 20.5 | GO:0003954 | NADH dehydrogenase activity(GO:0003954) |
| 0.7 | 19.3 | GO:0050321 | tau-protein kinase activity(GO:0050321) |
| 0.4 | 15.7 | GO:0051183 | vitamin transporter activity(GO:0051183) |
| 0.4 | 14.9 | GO:0005528 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
| 0.8 | 14.8 | GO:0036374 | glutathione hydrolase activity(GO:0036374) |
| 0.5 | 14.4 | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism(GO:0046933) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 77.1 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 27.4 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 18.3 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 17.4 | NABA MATRISOME ASSOCIATED | Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors |
| 0.2 | 16.5 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.2 | 14.8 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.1 | 14.4 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.1 | 13.4 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.2 | 13.2 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.2 | 12.1 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 55.9 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.4 | 36.3 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.3 | 26.2 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.3 | 24.8 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.3 | 22.0 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.3 | 19.3 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.2 | 15.5 | REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G | Genes involved in Vif-mediated degradation of APOBEC3G |
| 0.3 | 15.3 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.2 | 14.3 | REACTOME PIP3 ACTIVATES AKT SIGNALING | Genes involved in PIP3 activates AKT signaling |
| 0.2 | 14.1 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |