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SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for POU2F1

Z-value: 1.11

Motif logo

Transcription factors associated with POU2F1

Gene Symbol Gene ID Gene Info
ENSG00000143190.17 POU class 2 homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
POU2F1hg19_v2_chr1_+_167190066_1671901560.587.6e-03Click!

Activity profile of POU2F1 motif

Sorted Z-values of POU2F1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr2_-_113594279 5.84 ENST00000416750.1
ENST00000418817.1
ENST00000263341.2
interleukin 1, beta
chr3_-_111314230 4.59 ENST00000317012.4
zinc finger, BED-type containing 2
chr18_+_61144160 4.34 ENST00000489441.1
ENST00000424602.1
serpin peptidase inhibitor, clade B (ovalbumin), member 5
chr3_+_136676851 4.06 ENST00000309741.5
interleukin 20 receptor beta
chr3_+_136676707 3.96 ENST00000329582.4
interleukin 20 receptor beta
chr8_-_49833978 3.68 ENST00000020945.1
snail family zinc finger 2
chr6_+_106988986 3.59 ENST00000457437.1
ENST00000535438.1
absent in melanoma 1
chr2_+_173292059 3.53 ENST00000412899.1
ENST00000409532.1
integrin, alpha 6
chr5_+_125758865 3.50 ENST00000542322.1
ENST00000544396.1
GRAM domain containing 3
chr11_-_58343319 3.35 ENST00000395074.2
leupaxin
chr5_+_125758813 3.22 ENST00000285689.3
ENST00000515200.1
GRAM domain containing 3
chr3_+_118892411 3.16 ENST00000479520.1
ENST00000494855.1
uroplakin 1B
chr6_-_26216872 3.02 ENST00000244601.3
histone cluster 1, H2bg
chr3_-_121379739 2.90 ENST00000428394.2
ENST00000314583.3
hematopoietic cell-specific Lyn substrate 1
chr7_+_90338712 2.88 ENST00000265741.3
ENST00000406263.1
cyclin-dependent kinase 14
chr12_-_50616382 2.87 ENST00000552783.1
LIM domain and actin binding 1
chr10_+_118187379 2.79 ENST00000369230.3
pancreatic lipase-related protein 3
chr18_-_68004529 2.67 ENST00000578633.1
RP11-484N16.1
chr3_+_118892362 2.45 ENST00000497685.1
ENST00000264234.3
uroplakin 1B
chr17_+_7387677 2.36 ENST00000322644.6
polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
chr11_-_125366018 2.36 ENST00000527534.1
fasciculation and elongation protein zeta 1 (zygin I)
chr1_+_152975488 2.31 ENST00000542696.1
small proline-rich protein 3
chr5_+_125759140 2.26 ENST00000543198.1
GRAM domain containing 3
chr13_-_38172863 2.13 ENST00000541481.1
ENST00000379743.4
ENST00000379742.4
ENST00000379749.4
ENST00000541179.1
ENST00000379747.4
periostin, osteoblast specific factor
chr6_-_26124138 2.08 ENST00000314332.5
ENST00000396984.1
histone cluster 1, H2bc
chr2_+_210444142 2.06 ENST00000360351.4
ENST00000361559.4
microtubule-associated protein 2
chr8_-_101730061 2.03 ENST00000519100.1
poly(A) binding protein, cytoplasmic 1
chr3_-_74570291 1.87 ENST00000263665.6
contactin 3 (plasmacytoma associated)
chr8_-_29592736 1.83 ENST00000518623.1
long intergenic non-protein coding RNA 589
chr2_+_210443993 1.80 ENST00000392193.1
microtubule-associated protein 2
chr19_-_9731872 1.74 ENST00000424629.1
ENST00000326044.5
ENST00000354661.4
ENST00000435550.1
ENST00000444611.1
ENST00000421525.1
zinc finger protein 561
chr6_+_26217159 1.64 ENST00000303910.2
histone cluster 1, H2ae
chr1_-_113478603 1.60 ENST00000443580.1
solute carrier family 16 (monocarboxylate transporter), member 1
chr11_-_35547151 1.60 ENST00000378878.3
ENST00000529303.1
ENST00000278360.3
peptidase domain containing associated with muscle regeneration 1
chrX_+_57313113 1.59 ENST00000374900.4
fatty acid amide hydrolase 2
chr1_+_44398943 1.59 ENST00000372359.5
ENST00000414809.3
artemin
chr17_-_7387524 1.53 ENST00000311403.4
zinc finger and BTB domain containing 4
chr2_-_88285309 1.46 ENST00000420840.2
RANBP2-like and GRIP domain containing 2
chr10_+_13628921 1.44 ENST00000378572.3
pre-mRNA processing factor 18
chr18_-_61311485 1.43 ENST00000436264.1
ENST00000356424.6
ENST00000341074.5
serpin peptidase inhibitor, clade B (ovalbumin), member 4
chr3_-_48594248 1.41 ENST00000545984.1
ENST00000232375.3
ENST00000416568.1
ENST00000383734.2
ENST00000541519.1
ENST00000412035.1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
chr14_-_21270995 1.41 ENST00000555698.1
ENST00000397970.4
ENST00000340900.3
ribonuclease, RNase A family, 1 (pancreatic)
chr1_-_153283194 1.39 ENST00000290722.1
peptidoglycan recognition protein 3
chr7_-_143966381 1.38 ENST00000487179.1
CTAGE family, member 8
chr6_-_11779403 1.37 ENST00000414691.3
androgen-dependent TFPI-regulating protein
chr9_+_112887772 1.37 ENST00000259318.7
A kinase (PRKA) anchor protein 2
chr11_-_8892900 1.34 ENST00000526155.1
ENST00000524757.1
ENST00000527392.1
ENST00000534665.1
ENST00000525169.1
ENST00000527516.1
ENST00000533471.1
suppression of tumorigenicity 5
chr3_-_107777208 1.34 ENST00000398258.3
CD47 molecule
chr4_+_74301880 1.31 ENST00000395792.2
ENST00000226359.2
alpha-fetoprotein
chr4_-_909521 1.30 ENST00000511229.1
cyclin G associated kinase
chr3_+_197464046 1.29 ENST00000428738.1
forty-two-three domain containing 1
chr9_+_124088860 1.29 ENST00000373806.1
gelsolin
chr7_+_90338547 1.26 ENST00000446790.1
cyclin-dependent kinase 14
chr3_+_107318157 1.25 ENST00000406780.1
bobby sox homolog (Drosophila)
chr10_-_115904361 1.21 ENST00000428953.1
ENST00000543782.1
chromosome 10 open reading frame 118
chr3_+_133292574 1.09 ENST00000264993.3
CDV3 homolog (mouse)
chr1_+_104293028 1.08 ENST00000370079.3
amylase, alpha 1C (salivary)
chr6_+_26124373 1.06 ENST00000377791.2
ENST00000602637.1
histone cluster 1, H2ac
chr3_+_185046676 1.03 ENST00000428617.1
ENST00000443863.1
mitogen-activated protein kinase kinase kinase 13
chr4_-_110723134 1.03 ENST00000510800.1
ENST00000512148.1
complement factor I
chr4_-_152147579 1.02 ENST00000304527.4
ENST00000455740.1
ENST00000424281.1
ENST00000409598.4
SH3 domain containing 19
chr11_-_26588634 0.99 ENST00000436318.2
ENST00000281268.8
mucin 15, cell surface associated
chr7_+_143880559 0.99 ENST00000486333.1
CTAGE family, member 4
chr6_-_11779014 0.96 ENST00000229583.5
androgen-dependent TFPI-regulating protein
chr10_-_29811456 0.96 ENST00000535393.1
supervillin
chr7_+_116451100 0.94 ENST00000464223.1
ENST00000484325.1
capping protein (actin filament) muscle Z-line, alpha 2
chr12_+_27849378 0.93 ENST00000310791.2
RAB15 effector protein
chr20_+_39657454 0.93 ENST00000361337.2
topoisomerase (DNA) I
chr11_-_107729887 0.90 ENST00000525815.1
solute carrier family 35, member F2
chr14_-_21270561 0.90 ENST00000412779.2
ribonuclease, RNase A family, 1 (pancreatic)
chr22_-_29949657 0.89 ENST00000428374.1
THO complex 5
chr3_+_182983126 0.89 ENST00000481531.1
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
chr2_+_87135076 0.89 ENST00000409776.2
RANBP2-like and GRIP domain containing 1
chr4_+_126315091 0.88 ENST00000335110.5
FAT atypical cadherin 4
chr3_+_101546827 0.87 ENST00000461724.1
ENST00000483180.1
ENST00000394054.2
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
chr2_-_74007193 0.87 ENST00000377706.4
ENST00000443070.1
ENST00000272444.3
dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)
chr10_+_13628933 0.86 ENST00000417658.1
ENST00000320054.4
pre-mRNA processing factor 18
chr11_-_107729504 0.85 ENST00000265836.7
solute carrier family 35, member F2
chr5_-_133510456 0.84 ENST00000520417.1
S-phase kinase-associated protein 1
chr4_-_153274078 0.82 ENST00000263981.5
F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
chr11_-_128457446 0.80 ENST00000392668.4
v-ets avian erythroblastosis virus E26 oncogene homolog 1
chrY_+_15418467 0.79 ENST00000595988.1
Uncharacterized protein
chr1_+_196621002 0.77 ENST00000367429.4
ENST00000439155.2
complement factor H
chr3_+_196466710 0.74 ENST00000327134.3
p21 protein (Cdc42/Rac)-activated kinase 2
chr10_-_116286563 0.74 ENST00000369253.2
actin binding LIM protein 1
chr6_+_116832789 0.73 ENST00000368599.3
family with sequence similarity 26, member E
chr4_-_100356291 0.72 ENST00000476959.1
ENST00000482593.1
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
chr17_+_38171681 0.72 ENST00000225474.2
ENST00000331769.2
ENST00000394148.3
ENST00000577675.1
colony stimulating factor 3 (granulocyte)
chr11_-_107729287 0.71 ENST00000375682.4
solute carrier family 35, member F2
chr8_+_27238147 0.70 ENST00000412793.1
protein tyrosine kinase 2 beta
chr17_+_37844331 0.69 ENST00000578199.1
ENST00000406381.2
v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2
chr16_-_18462221 0.69 ENST00000528301.1
LOC339047 protein; Nuclear pore complex-interacting protein family member A3; Nuclear pore complex-interacting protein family member A5; Protein PKD1P1
chr4_-_110723335 0.67 ENST00000394634.2
complement factor I
chr7_-_84121858 0.65 ENST00000448879.1
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr6_-_132032206 0.64 ENST00000314099.8
CTAGE family, member 9
chr11_+_74459876 0.63 ENST00000299563.4
ring finger protein 169
chr4_+_74702214 0.61 ENST00000226317.5
ENST00000515050.1
chemokine (C-X-C motif) ligand 6
chr9_+_120466650 0.61 ENST00000355622.6
toll-like receptor 4
chr9_+_120466610 0.59 ENST00000394487.4
toll-like receptor 4
chr1_-_109935819 0.59 ENST00000538502.1
sortilin 1
chr10_+_91589261 0.58 ENST00000448963.1
long intergenic non-protein coding RNA 865
chr5_+_112227311 0.57 ENST00000391338.1
zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 1
chr9_-_140196703 0.57 ENST00000356628.2
NOTCH-regulated ankyrin repeat protein
chr4_-_110723194 0.57 ENST00000394635.3
complement factor I
chr6_-_132834184 0.56 ENST00000367941.2
ENST00000367937.4
syntaxin 7
chr4_-_100065440 0.56 ENST00000508393.1
ENST00000265512.7
alcohol dehydrogenase 4 (class II), pi polypeptide
chr1_+_104159999 0.56 ENST00000414303.2
ENST00000423678.1
amylase, alpha 2A (pancreatic)
chr1_-_226926864 0.55 ENST00000429204.1
ENST00000366784.1
inositol-trisphosphate 3-kinase B
chr12_-_91546926 0.55 ENST00000550758.1
decorin
chr18_-_24722995 0.54 ENST00000581714.1
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9
chr10_+_91589309 0.52 ENST00000448490.1
long intergenic non-protein coding RNA 865
chr4_+_106631966 0.52 ENST00000360505.5
ENST00000510865.1
ENST00000509336.1
glutathione S-transferase, C-terminal domain containing
chr5_-_111092873 0.52 ENST00000509025.1
ENST00000515855.1
neuronal regeneration related protein
chr1_+_28562617 0.51 ENST00000497986.1
ENST00000335514.5
ENST00000468425.2
ENST00000465645.1
ATPase inhibitory factor 1
chr20_+_50827175 0.50 ENST00000454600.1
RP4-723E3.1
chr6_-_11779174 0.50 ENST00000379413.2
androgen-dependent TFPI-regulating protein
chr22_+_41697520 0.50 ENST00000352645.4
zinc finger CCCH-type containing 7B
chr1_-_223308098 0.45 ENST00000342210.6
toll-like receptor 5
chr6_-_135424186 0.45 ENST00000529882.1
HBS1-like (S. cerevisiae)
chr7_+_37723450 0.45 ENST00000447769.1
G protein-coupled receptor 141
chr19_+_58258164 0.45 ENST00000317178.5
zinc finger protein 776
chr16_+_14980632 0.44 ENST00000565655.1
NODAL modulator 1
chr4_+_57276661 0.44 ENST00000598320.1
Uncharacterized protein
chr14_-_68283291 0.43 ENST00000555452.1
ENST00000347230.4
zinc finger, FYVE domain containing 26
chr1_+_161736072 0.43 ENST00000367942.3
activating transcription factor 6
chr1_-_6614565 0.41 ENST00000377705.5
nucleolar protein 9
chr2_+_62900986 0.41 ENST00000405015.3
ENST00000413434.1
ENST00000426940.1
ENST00000449820.1
EH domain binding protein 1
chr10_+_26932068 0.40 ENST00000544033.1
ENST00000454991.1
long intergenic non-protein coding RNA 202-2
RP13-16H11.7
chr18_+_44812072 0.40 ENST00000598649.1
ENST00000586905.2
CTD-2130O13.1
chr10_+_126630692 0.39 ENST00000359653.4
zinc finger, RAN-binding domain containing 1
chr1_+_25599018 0.38 ENST00000417538.2
ENST00000357542.4
ENST00000568195.1
ENST00000342055.5
ENST00000423810.2
Rh blood group, D antigen
chr6_+_135502408 0.38 ENST00000341911.5
ENST00000442647.2
ENST00000316528.8
v-myb avian myeloblastosis viral oncogene homolog
chr17_+_38171614 0.38 ENST00000583218.1
ENST00000394149.3
colony stimulating factor 3 (granulocyte)
chr7_+_37723336 0.38 ENST00000450180.1
G protein-coupled receptor 141
chr6_+_147527103 0.37 ENST00000179882.6
syntaxin binding protein 5 (tomosyn)
chr9_-_116065551 0.37 ENST00000297894.5
ring finger protein 183
chr11_-_16403910 0.36 ENST00000526673.1
SRY (sex determining region Y)-box 6
chr10_-_116286656 0.36 ENST00000428430.1
ENST00000369266.3
ENST00000392952.3
actin binding LIM protein 1
chr5_+_126626498 0.33 ENST00000503335.2
ENST00000508365.1
ENST00000418761.2
ENST00000274473.6
multiple EGF-like-domains 10
chr18_-_52989217 0.33 ENST00000570287.2
transcription factor 4
chr5_+_67588391 0.33 ENST00000523872.1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr19_+_14693888 0.30 ENST00000547437.1
ENST00000397439.2
ENST00000417570.1
C-type lectin domain family 17, member A
chr2_+_162087577 0.30 ENST00000439442.1
TRAF family member-associated NFKB activator
chr17_+_75181292 0.28 ENST00000431431.2
SEC14-like 1 (S. cerevisiae)
chr6_-_13621126 0.28 ENST00000600057.1
Uncharacterized protein
chr22_-_29949680 0.28 ENST00000397873.2
ENST00000490103.1
THO complex 5
chr5_-_13944652 0.28 ENST00000265104.4
dynein, axonemal, heavy chain 5
chr17_-_2304365 0.28 ENST00000575394.1
ENST00000174618.4
MAX network transcriptional repressor
chr2_+_90458201 0.28 ENST00000603238.1
Uncharacterized protein
chr13_+_108870714 0.27 ENST00000375898.3
abhydrolase domain containing 13
chr11_-_88799113 0.27 ENST00000393294.3
glutamate receptor, metabotropic 5
chr5_+_118668846 0.26 ENST00000513374.1
tumor necrosis factor, alpha-induced protein 8
chr8_-_117768023 0.26 ENST00000518949.1
ENST00000522453.1
ENST00000521861.1
ENST00000518995.1
eukaryotic translation initiation factor 3, subunit H
chr4_-_120550146 0.25 ENST00000354960.3
phosphodiesterase 5A, cGMP-specific
chr9_+_117904097 0.25 ENST00000374016.1
deleted in esophageal cancer 1
chr17_+_45728427 0.25 ENST00000540627.1
karyopherin (importin) beta 1
chr12_-_118797475 0.25 ENST00000541786.1
ENST00000419821.2
ENST00000541878.1
TAO kinase 3
chr1_-_89736434 0.24 ENST00000370459.3
guanylate binding protein 5
chr2_+_71205742 0.21 ENST00000360589.3
ankyrin repeat domain 53
chrX_-_99665262 0.21 ENST00000373034.4
ENST00000255531.7
protocadherin 19
chr18_-_69246186 0.21 ENST00000568095.1
RP11-510D19.1
chr11_+_94758422 0.20 ENST00000450979.2
lysine (K)-specific demethylase 4E
chr5_+_94982558 0.20 ENST00000311364.4
ENST00000458310.1
Rieske (Fe-S) domain containing
chr2_+_44001172 0.20 ENST00000260605.8
ENST00000406852.3
ENST00000443170.3
ENST00000398823.2
ENST00000605786.1
dynein, cytoplasmic 2, light intermediate chain 1
chr8_-_117886612 0.20 ENST00000520992.1
RAD21 homolog (S. pombe)
chr13_+_111855414 0.19 ENST00000375737.5
Rho guanine nucleotide exchange factor (GEF) 7
chr4_+_40194609 0.19 ENST00000508513.1
ras homolog family member H
chr2_-_152684977 0.19 ENST00000428992.2
ENST00000295087.8
ADP-ribosylation factor-like 5A
chr4_+_146539415 0.19 ENST00000281317.5
methylmalonic aciduria (cobalamin deficiency) cblA type
chr7_-_143582450 0.17 ENST00000485416.1
family with sequence similarity 115, member A
chr6_+_55192267 0.17 ENST00000340465.2
GDNF family receptor alpha like
chr22_-_37571089 0.17 ENST00000453962.1
ENST00000429622.1
ENST00000445595.1
interleukin 2 receptor, beta
chr1_+_146373546 0.17 ENST00000446760.2
neuroblastoma breakpoint family, member 12
chr6_+_135502501 0.17 ENST00000527615.1
ENST00000420123.2
ENST00000525369.1
ENST00000528774.1
ENST00000534121.1
ENST00000534044.1
ENST00000533624.1
v-myb avian myeloblastosis viral oncogene homolog
chrX_+_134478706 0.16 ENST00000370761.3
ENST00000339249.4
ENST00000370760.3
zinc finger protein 449
chr1_-_85097431 0.16 ENST00000327308.3
chromosome 1 open reading frame 180
chr9_+_116638630 0.15 ENST00000452710.1
ENST00000374124.4
zinc finger protein 618
chr1_-_17231271 0.15 ENST00000606899.1
RP11-108M9.6
chr16_+_14294187 0.15 ENST00000573051.1
MKL/myocardin-like 2
chr4_+_40194570 0.15 ENST00000507851.1
ras homolog family member H
chr1_-_146082633 0.15 ENST00000605317.1
ENST00000604938.1
ENST00000339388.5
neuroblastoma breakpoint family, member 11
chr6_+_135502466 0.15 ENST00000367814.4
v-myb avian myeloblastosis viral oncogene homolog
chr12_-_95510743 0.15 ENST00000551521.1
FYVE, RhoGEF and PH domain containing 6
chr5_-_98262240 0.15 ENST00000284049.3
chromodomain helicase DNA binding protein 1
chr5_+_150827143 0.14 ENST00000243389.3
ENST00000517945.1
ENST00000521925.1
solute carrier family 36 (proton/amino acid symporter), member 1
chr7_+_7606497 0.14 ENST00000340080.4
ENST00000405785.1
ENST00000433635.1
missing oocyte, meiosis regulator, homolog (Drosophila)
chr3_-_169587621 0.12 ENST00000523069.1
ENST00000316428.5
ENST00000264676.5
leucine rich repeat containing 31
chr1_+_25598872 0.12 ENST00000328664.4
Rh blood group, D antigen
chr12_-_72057571 0.12 ENST00000548100.1
zinc finger, C3H1-type containing
chrX_+_47050798 0.12 ENST00000412206.1
ENST00000427561.1
ubiquitin-like modifier activating enzyme 1
chr11_-_18063973 0.11 ENST00000528338.1
tryptophan hydroxylase 1
chr16_-_31228680 0.11 ENST00000302964.3
PYD (pyrin domain) containing 1
chr10_+_79793518 0.11 ENST00000440692.1
ENST00000435275.1
ENST00000372360.3
ENST00000360830.4
ribosomal protein S24
chr12_+_72056773 0.10 ENST00000308086.2
THAP domain containing, apoptosis associated protein 2
chr2_+_71205510 0.10 ENST00000272421.6
ENST00000441349.1
ENST00000457410.1
ankyrin repeat domain 53
chr5_-_111093081 0.10 ENST00000453526.2
ENST00000509427.1
neuronal regeneration related protein
chr12_-_111358372 0.09 ENST00000548438.1
ENST00000228841.8
myosin, light chain 2, regulatory, cardiac, slow
chr2_+_10223908 0.09 ENST00000425235.1
AC104794.4
chr2_+_191002486 0.09 ENST00000396974.2
chromosome 2 open reading frame 88
chr4_-_186570679 0.09 ENST00000451974.1
sorbin and SH3 domain containing 2

Network of associatons between targets according to the STRING database.

First level regulatory network of POU2F1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 8.0 GO:0001808 negative regulation of type IV hypersensitivity(GO:0001808)
1.2 3.7 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
0.8 2.4 GO:0001172 transcription, RNA-templated(GO:0001172)
0.8 2.3 GO:0071048 nuclear mRNA surveillance of spliceosomal pre-mRNA splicing(GO:0071030) nuclear retention of unspliced pre-mRNA at the site of transcription(GO:0071048)
0.7 5.8 GO:0070164 negative regulation of adiponectin secretion(GO:0070164)
0.5 1.6 GO:0051780 mevalonate transport(GO:0015728) behavioral response to nutrient(GO:0051780)
0.5 1.4 GO:0042270 protection from natural killer cell mediated cytotoxicity(GO:0042270)
0.5 1.4 GO:0032827 negative regulation of natural killer cell differentiation(GO:0032824) negative regulation of natural killer cell differentiation involved in immune response(GO:0032827) positive regulation of cytolysis in other organism(GO:0051714)
0.4 1.2 GO:0032707 negative regulation of interleukin-23 production(GO:0032707)
0.4 2.1 GO:0032571 response to vitamin K(GO:0032571) regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209) bone regeneration(GO:1990523)
0.3 3.4 GO:0050859 negative regulation of B cell receptor signaling pathway(GO:0050859)
0.3 1.3 GO:1905224 clathrin-coated pit assembly(GO:1905224)
0.3 1.6 GO:0097021 lymphocyte migration into lymphoid organs(GO:0097021)
0.3 1.3 GO:0044858 plasma membrane raft distribution(GO:0044855) plasma membrane raft localization(GO:0044856) plasma membrane raft polarization(GO:0044858) regulation of plasma membrane raft polarization(GO:1903906)
0.2 0.7 GO:1990922 regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922)
0.2 3.5 GO:0010668 ectodermal cell differentiation(GO:0010668)
0.2 0.9 GO:0072137 condensed mesenchymal cell proliferation(GO:0072137)
0.2 1.4 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.2 0.7 GO:0010430 fatty acid omega-oxidation(GO:0010430)
0.2 2.9 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.2 2.0 GO:2000623 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.2 0.8 GO:2000638 regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
0.2 0.6 GO:1903045 neural crest cell migration involved in sympathetic nervous system development(GO:1903045)
0.1 0.6 GO:1902683 regulation of receptor localization to synapse(GO:1902683)
0.1 0.7 GO:0033088 negative regulation of immature T cell proliferation in thymus(GO:0033088)
0.1 1.1 GO:0030223 neutrophil differentiation(GO:0030223)
0.1 0.4 GO:0098507 polynucleotide 5' dephosphorylation(GO:0098507)
0.1 0.7 GO:2001271 negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.1 2.1 GO:0002227 innate immune response in mucosa(GO:0002227)
0.1 1.2 GO:2000002 negative regulation of DNA damage checkpoint(GO:2000002)
0.1 0.8 GO:0030578 PML body organization(GO:0030578)
0.1 0.7 GO:2000538 regulation of cGMP-mediated signaling(GO:0010752) regulation of B cell chemotaxis(GO:2000537) positive regulation of B cell chemotaxis(GO:2000538)
0.1 0.4 GO:1990168 protein K33-linked deubiquitination(GO:1990168)
0.1 0.6 GO:0044245 polysaccharide digestion(GO:0044245)
0.1 0.8 GO:0010265 SCF complex assembly(GO:0010265)
0.1 0.2 GO:0072616 interleukin-18 secretion(GO:0072616)
0.1 4.3 GO:0060512 prostate gland morphogenesis(GO:0060512)
0.1 0.5 GO:0034146 toll-like receptor 5 signaling pathway(GO:0034146)
0.1 0.5 GO:1904925 positive regulation of macromitophagy(GO:1901526) positive regulation of mitophagy in response to mitochondrial depolarization(GO:1904925)
0.1 0.4 GO:0006990 positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response(GO:0006990)
0.1 0.6 GO:0014807 regulation of somitogenesis(GO:0014807)
0.1 2.5 GO:0000042 protein targeting to Golgi(GO:0000042)
0.1 0.5 GO:0033029 regulation of neutrophil apoptotic process(GO:0033029)
0.1 0.3 GO:0007206 phospholipase C-activating G-protein coupled glutamate receptor signaling pathway(GO:0007206)
0.1 0.9 GO:0040016 embryonic cleavage(GO:0040016)
0.1 1.2 GO:0001542 ovulation from ovarian follicle(GO:0001542)
0.1 0.4 GO:0021780 oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)
0.1 0.6 GO:0051005 negative regulation of lipoprotein lipase activity(GO:0051005)
0.1 2.4 GO:0051654 establishment of mitochondrion localization(GO:0051654)
0.1 0.1 GO:1900226 negative regulation of NLRP3 inflammasome complex assembly(GO:1900226)
0.1 1.0 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.1 0.3 GO:0031291 Ran protein signal transduction(GO:0031291)
0.0 0.3 GO:0043654 recognition of apoptotic cell(GO:0043654)
0.0 0.2 GO:0009236 cobalamin biosynthetic process(GO:0009236)
0.0 0.5 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.0 0.3 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.0 3.1 GO:0030835 negative regulation of actin filament depolymerization(GO:0030835)
0.0 2.3 GO:0018149 peptide cross-linking(GO:0018149)
0.0 0.3 GO:0060282 positive regulation of oocyte development(GO:0060282)
0.0 4.1 GO:0001578 microtubule bundle formation(GO:0001578)
0.0 0.6 GO:0006069 ethanol oxidation(GO:0006069)
0.0 0.4 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
0.0 0.3 GO:1902412 regulation of mitotic cytokinesis(GO:1902412)
0.0 0.6 GO:0090023 positive regulation of neutrophil chemotaxis(GO:0090023)
0.0 0.5 GO:0008228 opsonization(GO:0008228)
0.0 2.3 GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502)
0.0 0.2 GO:0038110 interleukin-2-mediated signaling pathway(GO:0038110)
0.0 0.3 GO:0045876 positive regulation of sister chromatid cohesion(GO:0045876)
0.0 0.3 GO:0039536 negative regulation of RIG-I signaling pathway(GO:0039536)
0.0 1.6 GO:0019369 arachidonic acid metabolic process(GO:0019369)
0.0 0.1 GO:0042427 serotonin biosynthetic process(GO:0042427)
0.0 0.1 GO:0060157 urinary bladder development(GO:0060157)
0.0 0.6 GO:2000780 negative regulation of double-strand break repair(GO:2000780)
0.0 0.9 GO:0033572 transferrin transport(GO:0033572)
0.0 1.9 GO:0016266 O-glycan processing(GO:0016266)
0.0 1.9 GO:0006501 C-terminal protein lipidation(GO:0006501)
0.0 0.3 GO:1900103 positive regulation of endoplasmic reticulum unfolded protein response(GO:1900103)
0.0 0.7 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.1 GO:0015808 L-alanine transport(GO:0015808)
0.0 0.5 GO:0015695 organic cation transport(GO:0015695)
0.0 0.5 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.0 0.2 GO:1904424 regulation of GTP binding(GO:1904424)
0.0 1.1 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 0.2 GO:0035721 intraciliary retrograde transport(GO:0035721)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 3.5 GO:0034676 integrin alpha6-beta4 complex(GO:0034676)
0.7 4.1 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.6 2.3 GO:0071020 post-spliceosomal complex(GO:0071020)
0.5 3.9 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.3 0.9 GO:0009330 DNA topoisomerase complex (ATP-hydrolyzing)(GO:0009330)
0.1 1.2 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.1 0.8 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.1 0.6 GO:0089701 U2AF(GO:0089701)
0.1 1.2 GO:0000445 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.1 2.0 GO:0000974 Prp19 complex(GO:0000974)
0.1 1.3 GO:0030478 actin cap(GO:0030478)
0.1 0.8 GO:0031467 Cul7-RING ubiquitin ligase complex(GO:0031467)
0.1 2.0 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.1 1.0 GO:0036449 microtubule minus-end(GO:0036449)
0.0 0.9 GO:0008290 F-actin capping protein complex(GO:0008290)
0.0 1.1 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.3 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
0.0 2.3 GO:0001533 cornified envelope(GO:0001533)
0.0 2.4 GO:0002102 podosome(GO:0002102)
0.0 2.1 GO:0000786 nucleosome(GO:0000786)
0.0 0.7 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 2.9 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 0.3 GO:0000798 nuclear cohesin complex(GO:0000798)
0.0 0.3 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.0 0.3 GO:0036157 outer dynein arm(GO:0036157)
0.0 2.1 GO:0031594 neuromuscular junction(GO:0031594)
0.0 0.4 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.2 GO:0000322 storage vacuole(GO:0000322)
0.0 0.3 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.5 GO:0005753 mitochondrial proton-transporting ATP synthase complex(GO:0005753)
0.0 1.6 GO:0005811 lipid particle(GO:0005811)
0.0 0.6 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.0 0.6 GO:0001772 immunological synapse(GO:0001772)
0.0 0.6 GO:0035861 site of double-strand break(GO:0035861)
0.0 1.5 GO:0005796 Golgi lumen(GO:0005796)
0.0 6.2 GO:0016324 apical plasma membrane(GO:0016324)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 8.0 GO:0042015 interleukin-20 binding(GO:0042015)
0.8 2.4 GO:0003968 RNA-directed RNA polymerase activity(GO:0003968)
0.5 1.6 GO:0015130 mevalonate transmembrane transporter activity(GO:0015130)
0.5 2.3 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
0.3 1.4 GO:0008745 N-acetylmuramoyl-L-alanine amidase activity(GO:0008745)
0.3 2.3 GO:0004522 ribonuclease A activity(GO:0004522)
0.3 3.5 GO:0038132 neuregulin binding(GO:0038132)
0.2 5.6 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.2 0.6 GO:0019115 benzaldehyde dehydrogenase activity(GO:0019115)
0.2 0.9 GO:0008457 beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity(GO:0008457) lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity(GO:0047256)
0.2 1.4 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873) fructose-2,6-bisphosphate 2-phosphatase activity(GO:0004331)
0.2 0.7 GO:0004031 aldehyde oxidase activity(GO:0004031)
0.2 0.5 GO:0030272 5-formyltetrahydrofolate cyclo-ligase activity(GO:0030272)
0.1 1.2 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.1 0.4 GO:0004651 polynucleotide 5'-phosphatase activity(GO:0004651)
0.1 0.6 GO:0004556 alpha-amylase activity(GO:0004556)
0.1 0.6 GO:0010465 nerve growth factor receptor activity(GO:0010465)
0.1 0.7 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.1 3.6 GO:0002162 dystroglycan binding(GO:0002162)
0.1 6.2 GO:0030332 cyclin binding(GO:0030332)
0.1 0.9 GO:0003917 DNA topoisomerase type I activity(GO:0003917)
0.1 1.3 GO:0070053 thrombospondin receptor activity(GO:0070053)
0.1 1.3 GO:0045159 myosin II binding(GO:0045159)
0.1 2.8 GO:0004806 triglyceride lipase activity(GO:0004806)
0.1 0.4 GO:0051731 polynucleotide 5'-hydroxyl-kinase activity(GO:0051731)
0.1 0.6 GO:0030628 pre-mRNA 3'-splice site binding(GO:0030628)
0.1 0.5 GO:0047756 chondroitin 4-sulfotransferase activity(GO:0047756)
0.1 0.7 GO:0001042 RNA polymerase I core binding(GO:0001042)
0.1 0.5 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
0.1 2.0 GO:0008266 poly(U) RNA binding(GO:0008266)
0.1 3.0 GO:0003785 actin monomer binding(GO:0003785)
0.1 2.4 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 0.3 GO:0039552 RIG-I binding(GO:0039552)
0.0 0.6 GO:0045499 chemorepellent activity(GO:0045499)
0.0 0.7 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.0 0.3 GO:0042806 fucose binding(GO:0042806)
0.0 0.6 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.0 0.6 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.0 1.6 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 0.3 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.0 0.2 GO:0004911 interleukin-2 receptor activity(GO:0004911) interleukin-2 binding(GO:0019976)
0.0 4.9 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.3 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
0.0 0.8 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 0.8 GO:0097602 cullin family protein binding(GO:0097602)
0.0 1.0 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.0 2.6 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 0.1 GO:0004510 tryptophan 5-monooxygenase activity(GO:0004510)
0.0 1.0 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.0 0.1 GO:0051800 phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity(GO:0051800)
0.0 0.4 GO:0035497 cAMP response element binding(GO:0035497)
0.0 4.0 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 0.3 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 0.8 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 1.3 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.1 GO:0022858 L-alanine transmembrane transporter activity(GO:0015180) alanine transmembrane transporter activity(GO:0022858)
0.0 0.5 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.0 0.5 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 2.5 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.0 0.1 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.0 0.1 GO:0004064 arylesterase activity(GO:0004064)
0.0 0.3 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.0 1.5 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 5.8 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 3.5 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 1.3 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
0.0 0.5 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.0 4.3 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 1.3 PID ERBB1 RECEPTOR PROXIMAL PATHWAY EGF receptor (ErbB1) signaling pathway
0.0 1.6 PID MYC PATHWAY C-MYC pathway
0.0 1.2 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 2.9 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 3.6 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 0.7 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 0.8 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin
0.0 2.3 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 2.6 PID LKB1 PATHWAY LKB1 signaling events
0.0 0.9 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.0 0.7 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling
0.0 1.1 PID MET PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.0 1.0 ST JNK MAPK PATHWAY JNK MAPK Pathway
0.0 1.3 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 6.7 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.1 1.7 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.1 1.2 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.1 3.0 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.1 2.4 REACTOME VIRAL MESSENGER RNA SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.1 6.3 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.1 1.6 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.1 1.3 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.0 2.0 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 1.1 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.0 1.4 REACTOME SEMA3A PAK DEPENDENT AXON REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
0.0 1.3 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 0.4 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.9 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.0 1.4 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 1.1 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 2.5 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 1.0 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 1.4 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.0 0.6 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 0.7 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 0.3 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 0.9 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.8 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 1.0 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.5 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling