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SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for POU3F2
Z-value: 1.72
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Transcription factors associated with POU3F2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| POU3F2 | hg19_v2_chr6_+_99282570_99282591 | -0.21 | 3.8e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of POU3F2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 14.0 | GO:0018149 | peptide cross-linking(GO:0018149) |
| 0.1 | 8.1 | GO:0006891 | intra-Golgi vesicle-mediated transport(GO:0006891) |
| 0.2 | 7.5 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.1 | 6.8 | GO:0090162 | establishment of epithelial cell polarity(GO:0090162) |
| 0.7 | 6.1 | GO:0035234 | ectopic germ cell programmed cell death(GO:0035234) |
| 0.5 | 5.8 | GO:0060753 | regulation of mast cell chemotaxis(GO:0060753) |
| 0.1 | 5.8 | GO:0010508 | positive regulation of autophagy(GO:0010508) |
| 0.1 | 5.6 | GO:0010507 | negative regulation of autophagy(GO:0010507) |
| 0.9 | 5.4 | GO:0006436 | tryptophanyl-tRNA aminoacylation(GO:0006436) |
| 0.1 | 5.3 | GO:0035722 | interleukin-12-mediated signaling pathway(GO:0035722) cellular response to interleukin-12(GO:0071349) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 28.0 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.3 | 19.3 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.1 | 12.0 | GO:0032432 | actin filament bundle(GO:0032432) |
| 0.2 | 8.4 | GO:0031233 | intrinsic component of external side of plasma membrane(GO:0031233) |
| 0.0 | 7.2 | GO:0010008 | endosome membrane(GO:0010008) |
| 0.2 | 6.6 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.2 | 5.6 | GO:0031588 | nucleotide-activated protein kinase complex(GO:0031588) |
| 0.0 | 5.6 | GO:0043296 | apical junction complex(GO:0043296) |
| 0.0 | 5.2 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.0 | 5.1 | GO:0005667 | transcription factor complex(GO:0005667) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 31.7 | GO:0003700 | transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 0.2 | 25.7 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 19.7 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.0 | 15.5 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.0 | 9.5 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.1 | 7.5 | GO:0002039 | p53 binding(GO:0002039) |
| 0.3 | 6.3 | GO:0005149 | interleukin-1 receptor binding(GO:0005149) |
| 0.1 | 5.7 | GO:0070840 | dynein complex binding(GO:0070840) |
| 0.9 | 5.4 | GO:0004830 | tryptophan-tRNA ligase activity(GO:0004830) |
| 0.0 | 5.4 | GO:0005525 | GTP binding(GO:0005525) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 28.2 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 11.6 | PID A6B1 A6B4 INTEGRIN PATHWAY | a6b1 and a6b4 Integrin signaling |
| 0.1 | 7.3 | ST P38 MAPK PATHWAY | p38 MAPK Pathway |
| 0.1 | 6.1 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.1 | 6.1 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.1 | 5.6 | PID FAK PATHWAY | Signaling events mediated by focal adhesion kinase |
| 0.1 | 5.3 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.1 | 5.2 | PID BETA CATENIN DEG PATHWAY | Degradation of beta catenin |
| 0.1 | 4.8 | PID MYC PATHWAY | C-MYC pathway |
| 0.2 | 4.7 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 15.3 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.1 | 9.6 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.1 | 8.6 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.2 | 7.1 | REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| 0.1 | 6.8 | REACTOME SIGNALING BY BMP | Genes involved in Signaling by BMP |
| 0.0 | 6.2 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.2 | 6.1 | REACTOME INFLAMMASOMES | Genes involved in Inflammasomes |
| 0.0 | 5.7 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 0.1 | 5.3 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.1 | 5.3 | REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM | Genes involved in Transport of Mature Transcript to Cytoplasm |