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SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for POU4F1_POU4F3
Z-value: 1.16
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Transcription factors associated with POU4F1_POU4F3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| POU4F1 | hg19_v2_chr13_-_79177673_79177701 | 0.89 | 1.9e-07 | Click! |
| POU4F3 | hg19_v2_chr5_+_145718587_145718607 | -0.12 | 6.3e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr12_+_49740700 Show fit | 5.71 |
ENST00000549441.2
ENST00000395069.3 |
DnaJ (Hsp40) homolog, subfamily C, member 22 |
|
| chr1_+_66458072 Show fit | 4.49 |
ENST00000423207.2
|
phosphodiesterase 4B, cAMP-specific |
|
| chr22_-_30970560 Show fit | 4.13 |
ENST00000402369.1
ENST00000406361.1 |
galactose-3-O-sulfotransferase 1 |
|
| chr9_-_123812542 Show fit | 3.85 |
ENST00000223642.1
|
complement component 5 |
|
| chr12_+_41221794 Show fit | 3.84 |
ENST00000547849.1
|
contactin 1 |
|
| chr14_-_65409502 Show fit | 3.81 |
ENST00000389614.5
|
glutathione peroxidase 2 (gastrointestinal) |
|
| chr2_-_101034070 Show fit | 2.98 |
ENST00000264249.3
|
carbohydrate sulfotransferase 10 |
|
| chr16_+_15596123 Show fit | 2.95 |
ENST00000452191.2
|
chromosome 16 open reading frame 45 |
|
| chr8_+_98900132 Show fit | 2.89 |
ENST00000520016.1
|
matrilin 2 |
|
| chr12_+_41221975 Show fit | 2.67 |
ENST00000552913.1
|
contactin 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of POU4F1_POU4F3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 8.5 | GO:1901898 | negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898) |
| 0.5 | 6.4 | GO:0006682 | galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375) |
| 0.0 | 5.9 | GO:0098869 | cellular oxidant detoxification(GO:0098869) |
| 0.7 | 4.0 | GO:0010760 | negative regulation of macrophage chemotaxis(GO:0010760) |
| 0.1 | 4.0 | GO:0006337 | nucleosome disassembly(GO:0006337) |
| 0.1 | 3.9 | GO:0044458 | motile cilium assembly(GO:0044458) |
| 0.1 | 3.7 | GO:0010765 | positive regulation of sodium ion transport(GO:0010765) |
| 0.6 | 3.1 | GO:0010730 | negative regulation of hydrogen peroxide biosynthetic process(GO:0010730) positive regulation of skeletal muscle satellite cell proliferation(GO:1902724) positive regulation of growth factor dependent skeletal muscle satellite cell proliferation(GO:1902728) |
| 0.7 | 3.0 | GO:0042264 | peptidyl-aspartic acid hydroxylation(GO:0042264) |
| 0.4 | 3.0 | GO:1903976 | negative regulation of glial cell migration(GO:1903976) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 6.0 | GO:0000930 | gamma-tubulin complex(GO:0000930) |
| 0.0 | 4.3 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.5 | 3.9 | GO:0005579 | membrane attack complex(GO:0005579) |
| 0.0 | 3.6 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.0 | 3.1 | GO:0005905 | clathrin-coated pit(GO:0005905) |
| 0.3 | 2.8 | GO:0032541 | cortical endoplasmic reticulum(GO:0032541) |
| 0.1 | 2.5 | GO:0043194 | axon initial segment(GO:0043194) |
| 0.0 | 2.4 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.0 | 2.3 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.1 | 2.2 | GO:0071439 | clathrin complex(GO:0071439) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 9.3 | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) |
| 0.0 | 6.5 | GO:0030246 | carbohydrate binding(GO:0030246) |
| 0.5 | 6.4 | GO:0050694 | galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694) |
| 0.2 | 5.9 | GO:0004602 | glutathione peroxidase activity(GO:0004602) |
| 0.2 | 3.9 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 0.1 | 3.8 | GO:0008009 | chemokine activity(GO:0008009) |
| 0.3 | 3.1 | GO:0031730 | CCR5 chemokine receptor binding(GO:0031730) |
| 1.0 | 3.0 | GO:0004597 | peptide-aspartate beta-dioxygenase activity(GO:0004597) |
| 0.0 | 3.0 | GO:0008146 | sulfotransferase activity(GO:0008146) |
| 0.0 | 2.7 | GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.9 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 3.7 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 3.5 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.2 | 3.1 | ST STAT3 PATHWAY | STAT3 Pathway |
| 0.0 | 1.9 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.0 | 1.5 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.0 | 1.3 | PID BMP PATHWAY | BMP receptor signaling |
| 0.0 | 1.0 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.0 | 0.9 | PID RHOA PATHWAY | RhoA signaling pathway |
| 0.0 | 0.9 | SIG PIP3 SIGNALING IN B LYMPHOCYTES | Genes related to PIP3 signaling in B lymphocytes |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.5 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.1 | 6.7 | REACTOME GLYCOSPHINGOLIPID METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.1 | 6.5 | REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
| 0.1 | 3.9 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
| 0.2 | 3.1 | REACTOME IL 6 SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.1 | 2.5 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.0 | 2.0 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 0.0 | 2.0 | REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING | Genes involved in p75 NTR receptor-mediated signalling |
| 0.0 | 1.7 | REACTOME NEPHRIN INTERACTIONS | Genes involved in Nephrin interactions |
| 0.0 | 1.0 | REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |