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SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for POU4F1_POU4F3

Z-value: 1.16

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Transcription factors associated with POU4F1_POU4F3

Gene Symbol Gene ID Gene Info
ENSG00000152192.6 POU class 4 homeobox 1
ENSG00000091010.4 POU class 4 homeobox 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
POU4F1hg19_v2_chr13_-_79177673_791777010.891.9e-07Click!
POU4F3hg19_v2_chr5_+_145718587_145718607-0.126.3e-01Click!

Activity profile of POU4F1_POU4F3 motif

Sorted Z-values of POU4F1_POU4F3 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr12_+_49740700 5.71 ENST00000549441.2
ENST00000395069.3
DnaJ (Hsp40) homolog, subfamily C, member 22
chr1_+_66458072 4.49 ENST00000423207.2
phosphodiesterase 4B, cAMP-specific
chr22_-_30970560 4.13 ENST00000402369.1
ENST00000406361.1
galactose-3-O-sulfotransferase 1
chr9_-_123812542 3.85 ENST00000223642.1
complement component 5
chr12_+_41221794 3.84 ENST00000547849.1
contactin 1
chr14_-_65409502 3.81 ENST00000389614.5
glutathione peroxidase 2 (gastrointestinal)
chr2_-_101034070 2.98 ENST00000264249.3
carbohydrate sulfotransferase 10
chr16_+_15596123 2.95 ENST00000452191.2
chromosome 16 open reading frame 45
chr8_+_98900132 2.89 ENST00000520016.1
matrilin 2
chr12_+_41221975 2.67 ENST00000552913.1
contactin 1
chr17_-_38821373 2.65 ENST00000394052.3
keratin 222
chrX_-_15288154 2.37 ENST00000380483.3
ENST00000380485.3
ENST00000380488.4
ankyrin repeat and SOCS box containing 9
chr19_+_17865011 2.28 ENST00000596462.1
ENST00000596865.1
ENST00000598960.1
ENST00000539407.1
FCH domain only 1
chr22_-_30970498 2.27 ENST00000431313.1
galactose-3-O-sulfotransferase 1
chr22_-_38506619 2.16 ENST00000332536.5
ENST00000381669.3
BAI1-associated protein 2-like 2
chr8_-_62602327 2.10 ENST00000445642.3
ENST00000517847.2
ENST00000389204.4
ENST00000517661.1
ENST00000517903.1
ENST00000522603.1
ENST00000522349.1
ENST00000522835.1
ENST00000541428.1
ENST00000518306.1
aspartate beta-hydroxylase
chr19_+_48949030 2.08 ENST00000253237.5
glutamate-rich WD repeat containing 1
chr14_-_65409438 2.04 ENST00000557049.1
glutathione peroxidase 2 (gastrointestinal)
chr19_-_55677999 2.01 ENST00000532817.1
ENST00000527223.2
ENST00000391720.4
dynein, axonemal, assembly factor 3
chr3_-_149375783 1.96 ENST00000467467.1
ENST00000460517.1
ENST00000360632.3
WW domain containing transcription regulator 1
chr19_-_55677920 1.90 ENST00000524407.2
ENST00000526003.1
ENST00000534170.1
dynein, axonemal, assembly factor 3
chr11_-_559377 1.86 ENST00000486629.1
chromosome 11 open reading frame 35
chr11_+_123430948 1.85 ENST00000529432.1
ENST00000534764.1
GRAM domain containing 1B
chr19_+_48949087 1.80 ENST00000598711.1
glutamate-rich WD repeat containing 1
chr6_+_127898312 1.77 ENST00000329722.7
chromosome 6 open reading frame 58
chr7_-_107880508 1.57 ENST00000425651.2
neuronal cell adhesion molecule
chr5_-_58295712 1.54 ENST00000317118.8
phosphodiesterase 4D, cAMP-specific
chr14_-_54908043 1.53 ENST00000556113.1
ENST00000553660.1
ENST00000395573.4
ENST00000557690.1
ENST00000216416.4
cornichon family AMPA receptor auxiliary protein 1
chr7_-_35013217 1.52 ENST00000446375.1
dpy-19-like 1 (C. elegans)
chr2_-_121624973 1.49 ENST00000603720.1
RP11-297J22.1
chr6_-_136847610 1.47 ENST00000454590.1
ENST00000432797.2
microtubule-associated protein 7
chr1_+_66820058 1.46 ENST00000480109.2
phosphodiesterase 4B, cAMP-specific
chr2_-_55237484 1.45 ENST00000394609.2
reticulon 4
chr6_-_127840453 1.36 ENST00000556132.1
SOGA family member 3
chr6_-_116833500 1.34 ENST00000356128.4
trafficking protein particle complex 3-like
chr6_-_127840021 1.31 ENST00000465909.2
SOGA family member 3
chr19_+_19639704 1.30 ENST00000514277.4
YjeF N-terminal domain containing 3
chr6_-_127840336 1.28 ENST00000525778.1
SOGA family member 3
chr14_-_54425475 1.26 ENST00000559642.1
bone morphogenetic protein 4
chr17_-_40540377 1.25 ENST00000404395.3
ENST00000389272.3
ENST00000585517.1
ENST00000588065.1
signal transducer and activator of transcription 3 (acute-phase response factor)
chr19_+_19639670 1.25 ENST00000436027.5
YjeF N-terminal domain containing 3
chr3_-_185826718 1.20 ENST00000413301.1
ENST00000421809.1
ets variant 5
chr10_-_22292675 1.19 ENST00000376946.1
DnaJ (Hsp40) homolog, subfamily C, member 1
chr14_-_101036119 1.18 ENST00000355173.2
brain-enriched guanylate kinase-associated
chr3_-_185826855 1.18 ENST00000306376.5
ets variant 5
chr4_-_89442940 1.15 ENST00000527353.1
phosphatidylinositol glycan anchor biosynthesis, class Y
chr3_+_98699880 1.14 ENST00000473756.1
long intergenic non-protein coding RNA 973
chr2_+_170590321 1.11 ENST00000392647.2
kelch-like family member 23
chr4_+_141264597 1.09 ENST00000338517.4
ENST00000394203.3
ENST00000506322.1
short coiled-coil protein
chr19_-_39402798 1.08 ENST00000571838.1
coiled-coil glutamate-rich protein 2
chr19_+_54466179 1.08 ENST00000270458.2
calcium channel, voltage-dependent, gamma subunit 8
chr17_-_40540484 1.06 ENST00000588969.1
signal transducer and activator of transcription 3 (acute-phase response factor)
chr20_+_36405665 1.04 ENST00000373469.1
catenin, beta like 1
chr4_-_122744998 0.99 ENST00000274026.5
cyclin A2
chr1_+_8378140 0.98 ENST00000377479.2
solute carrier family 45, member 1
chr5_-_59481406 0.96 ENST00000546160.1
phosphodiesterase 4D, cAMP-specific
chr12_+_51985001 0.93 ENST00000354534.6
sodium channel, voltage gated, type VIII, alpha subunit
chr12_-_120241187 0.93 ENST00000392520.2
citron (rho-interacting, serine/threonine kinase 21)
chr6_-_18249971 0.93 ENST00000507591.1
DEK oncogene
chr1_+_198608146 0.91 ENST00000367376.2
ENST00000352140.3
ENST00000594404.1
ENST00000598951.1
ENST00000530727.1
ENST00000442510.2
ENST00000367367.4
ENST00000348564.6
ENST00000367364.1
ENST00000413409.2
protein tyrosine phosphatase, receptor type, C
chr19_+_39138271 0.90 ENST00000252699.2
actinin, alpha 4
chr8_-_62559366 0.88 ENST00000522919.1
aspartate beta-hydroxylase
chr6_+_126102292 0.87 ENST00000368357.3
nuclear receptor coactivator 7
chr6_-_127840048 0.86 ENST00000467753.1
SOGA family member 3
chr20_-_23731893 0.86 ENST00000398402.1
cystatin SN
chr12_+_79357815 0.86 ENST00000547046.1
synaptotagmin I
chr17_+_7155819 0.84 ENST00000570322.1
ENST00000576496.1
ENST00000574841.2
elongator acetyltransferase complex subunit 5
chr19_-_46580352 0.84 ENST00000601672.1
IGF-like family member 4
chrX_-_106146547 0.83 ENST00000276173.4
ENST00000411805.1
ripply transcriptional repressor 1
chr16_-_70835034 0.81 ENST00000261776.5
Vac14 homolog (S. cerevisiae)
chr10_+_135207623 0.79 ENST00000317502.6
ENST00000432508.3
mitochondrial ribosome-associated GTPase 1
chr19_+_39138320 0.78 ENST00000424234.2
ENST00000390009.3
ENST00000589528.1
actinin, alpha 4
chr17_-_40540586 0.77 ENST00000264657.5
signal transducer and activator of transcription 3 (acute-phase response factor)
chr11_-_124981475 0.76 ENST00000532156.1
ENST00000532407.1
ENST00000279968.4
ENST00000527766.1
ENST00000529583.1
ENST00000524373.1
ENST00000527271.1
ENST00000526175.1
ENST00000529609.1
ENST00000533273.1
ENST00000531909.1
ENST00000529530.1
transmembrane protein 218
chr7_+_150725510 0.74 ENST00000461373.1
ENST00000358849.4
ENST00000297504.6
ENST00000542328.1
ENST00000498578.1
ENST00000356058.4
ENST00000477719.1
ENST00000477092.1
ATP-binding cassette, sub-family B (MDR/TAP), member 8
chrX_-_138724994 0.74 ENST00000536274.1
MCF.2 cell line derived transforming sequence
chr22_-_39268308 0.73 ENST00000407418.3
chromobox homolog 6
chr3_-_155011483 0.73 ENST00000489090.1
RP11-451G4.2
chr3_+_35722424 0.72 ENST00000396481.2
cAMP-regulated phosphoprotein, 21kDa
chr14_-_80697396 0.70 ENST00000557010.1
deiodinase, iodothyronine, type II
chr2_+_183582774 0.70 ENST00000537515.1
DnaJ (Hsp40) homolog, subfamily C, member 10
chr2_+_197577841 0.69 ENST00000409270.1
coiled-coil domain containing 150
chr18_-_31803435 0.69 ENST00000589544.1
ENST00000269185.4
ENST00000261592.5
nucleolar protein 4
chr9_-_85882145 0.69 ENST00000328788.1
FERM domain containing 3
chr12_-_58212487 0.68 ENST00000549994.1
advillin
chr6_-_136847099 0.67 ENST00000438100.2
microtubule-associated protein 7
chr10_+_135207598 0.67 ENST00000477902.2
mitochondrial ribosome-associated GTPase 1
chr1_+_81001398 0.67 ENST00000418041.1
ENST00000443104.1
RP5-887A10.1
chr10_+_33271469 0.66 ENST00000414157.1
RP11-462L8.1
chr14_+_39583427 0.65 ENST00000308317.6
ENST00000396249.2
ENST00000250379.8
ENST00000534684.2
ENST00000527381.1
gem (nuclear organelle) associated protein 2
chr5_+_68860949 0.64 ENST00000507595.1
general transcription factor IIH, polypeptide 2C
chr2_+_161993465 0.63 ENST00000457476.1
TRAF family member-associated NFKB activator
chrX_+_65382381 0.62 ENST00000519389.1
hephaestin
chr6_-_26108355 0.61 ENST00000338379.4
histone cluster 1, H1t
chr2_+_133174147 0.61 ENST00000329321.3
G protein-coupled receptor 39
chr9_-_4666421 0.59 ENST00000381895.5
spermatogenesis associated 6-like
chr3_-_33686743 0.58 ENST00000333778.6
ENST00000539981.1
cytoplasmic linker associated protein 2
chrX_-_1331527 0.58 ENST00000381567.3
ENST00000381566.1
ENST00000400841.2
cytokine receptor-like factor 2
chr9_+_67977438 0.58 ENST00000456982.1
Protein LOC644249
chr3_+_141043050 0.58 ENST00000509842.1
zinc finger and BTB domain containing 38
chr3_+_35722487 0.57 ENST00000441454.1
cAMP-regulated phosphoprotein, 21kDa
chrX_+_10126488 0.57 ENST00000380829.1
ENST00000421085.2
ENST00000454850.1
chloride channel, voltage-sensitive 4
chr2_-_3504587 0.56 ENST00000415131.1
acireductone dioxygenase 1
chr2_+_190541153 0.56 ENST00000313581.4
ENST00000438402.2
ENST00000431575.2
ENST00000281412.6
ankyrin and armadillo repeat containing
chr19_-_36304201 0.55 ENST00000301175.3
proline dehydrogenase (oxidase) 2
chr6_-_152623231 0.54 ENST00000540663.1
ENST00000537033.1
spectrin repeat containing, nuclear envelope 1
chr10_+_695888 0.54 ENST00000441152.2
proline rich 26
chr6_-_10115007 0.53 ENST00000485268.1
orofacial cleft 1 candidate 1
chr10_-_74283694 0.53 ENST00000398763.4
ENST00000418483.2
ENST00000489666.2
mitochondrial calcium uptake 1
chr1_+_160336851 0.53 ENST00000302101.5
nescient helix loop helix 1
chrX_+_47050798 0.53 ENST00000412206.1
ENST00000427561.1
ubiquitin-like modifier activating enzyme 1
chr11_-_8290263 0.52 ENST00000428101.2
LIM domain only 1 (rhombotin 1)
chr12_-_42631529 0.52 ENST00000548917.1
YY1 associated factor 2
chr16_+_619931 0.52 ENST00000321878.5
ENST00000439574.1
ENST00000026218.5
ENST00000470411.2
phosphatidylinositol glycan anchor biosynthesis, class Q
chr10_+_104614008 0.51 ENST00000369883.3
chromosome 10 open reading frame 32
chr5_+_129083772 0.51 ENST00000564719.1
KIAA1024-like
chr10_-_22292613 0.49 ENST00000376980.3
DnaJ (Hsp40) homolog, subfamily C, member 1
chr2_+_179317994 0.48 ENST00000375129.4
deafness, autosomal recessive 59
chr3_-_33686925 0.48 ENST00000485378.2
ENST00000313350.6
ENST00000487200.1
cytoplasmic linker associated protein 2
chr5_+_61874562 0.47 ENST00000334994.5
ENST00000409534.1
leucine rich repeat containing 70
importin 11
chr12_-_51611477 0.46 ENST00000389243.4
POU class 6 homeobox 1
chrX_+_23682379 0.45 ENST00000379349.1
peroxiredoxin 4
chr3_+_151591422 0.44 ENST00000362032.5
succinate receptor 1
chr3_+_158787041 0.44 ENST00000471575.1
ENST00000476809.1
ENST00000485419.1
IQCJ-SCHIP1 readthrough
chr10_-_112678904 0.44 ENST00000423273.1
ENST00000436562.1
ENST00000447005.1
ENST00000454061.1
BBSome interacting protein 1
chr14_+_31494841 0.44 ENST00000556232.1
ENST00000216366.4
ENST00000334725.4
ENST00000554609.1
ENST00000554345.1
adaptor-related protein complex 4, sigma 1 subunit
chr2_+_218994002 0.43 ENST00000428565.1
chemokine (C-X-C motif) receptor 2
chr19_-_51141196 0.43 ENST00000338916.4
synaptotagmin III
chr1_+_81106951 0.41 ENST00000443565.1
RP5-887A10.1
chr1_+_165864800 0.41 ENST00000469256.2
uridine-cytidine kinase 2
chr10_+_104613980 0.40 ENST00000339834.5
chromosome 10 open reading frame 32
chrX_+_65382433 0.40 ENST00000374727.3
hephaestin
chr17_-_38956205 0.40 ENST00000306658.7
keratin 28
chr17_-_72855989 0.39 ENST00000293190.5
glutamate receptor, ionotropic, N-methyl D-aspartate 2C
chrX_-_138724677 0.39 ENST00000370573.4
ENST00000338585.6
ENST00000370576.4
MCF.2 cell line derived transforming sequence
chr12_-_91574142 0.39 ENST00000547937.1
decorin
chr5_-_77844974 0.39 ENST00000515007.2
lipoma HMGIC fusion partner-like 2
chr1_+_165864821 0.39 ENST00000470820.1
uridine-cytidine kinase 2
chr21_+_45937497 0.38 ENST00000354333.5
chromosome 21 open reading frame 90
chr14_+_31494672 0.38 ENST00000542754.2
ENST00000313566.6
adaptor-related protein complex 4, sigma 1 subunit
chr15_-_52587945 0.37 ENST00000443683.2
ENST00000558479.1
ENST00000261839.7
myosin VC
chr10_+_696000 0.36 ENST00000381489.5
proline rich 26
chr12_+_110011571 0.36 ENST00000539696.1
ENST00000228510.3
ENST00000392727.3
mevalonate kinase
chr7_+_99195677 0.35 ENST00000431679.1
GS1-259H13.2
chr9_-_4666337 0.35 ENST00000381890.5
spermatogenesis associated 6-like
chr2_-_70475730 0.34 ENST00000445587.1
ENST00000433529.2
ENST00000415783.2
TIA1 cytotoxic granule-associated RNA binding protein
chr3_+_35722844 0.33 ENST00000436702.1
ENST00000438071.1
cAMP-regulated phosphoprotein, 21kDa
chr3_+_186158169 0.33 ENST00000435548.1
ENST00000421006.1
RP11-78H24.1
chr12_+_122880045 0.33 ENST00000539034.1
ENST00000535976.1
RP11-450K4.1
chr17_-_5321549 0.32 ENST00000572809.1
nucleoporin 88kDa
chr10_-_112678692 0.32 ENST00000605742.1
BBSome interacting protein 1
chr16_+_69221028 0.32 ENST00000336278.4
syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)
chr5_+_139739772 0.32 ENST00000506757.2
ENST00000230993.6
ENST00000506545.1
ENST00000432095.2
ENST00000507527.1
solute carrier family 4, sodium bicarbonate cotransporter, member 9
chr1_-_216978709 0.32 ENST00000360012.3
estrogen-related receptor gamma
chr10_-_112678976 0.32 ENST00000448814.1
BBSome interacting protein 1
chr4_-_25032501 0.31 ENST00000382114.4
leucine-rich repeat LGI family, member 2
chr10_-_11574274 0.31 ENST00000277575.5
USP6 N-terminal like
chr16_+_31366536 0.31 ENST00000562522.1
integrin, alpha X (complement component 3 receptor 4 subunit)
chr1_+_161691353 0.31 ENST00000367948.2
Fc receptor-like B
chr12_+_41831485 0.31 ENST00000539469.2
ENST00000298919.7
PDZ domain containing ring finger 4
chr4_+_102711764 0.31 ENST00000322953.4
ENST00000428908.1
B-cell scaffold protein with ankyrin repeats 1
chrX_+_78003204 0.31 ENST00000435339.3
ENST00000514744.1
lysophosphatidic acid receptor 4
chr7_-_64023410 0.31 ENST00000447137.2
zinc finger protein 680
chr12_+_16109519 0.30 ENST00000526530.1
deoxyribose-phosphate aldolase (putative)
chr1_+_101003687 0.30 ENST00000315033.4
G protein-coupled receptor 88
chr15_+_49447947 0.30 ENST00000327171.3
ENST00000560654.1
galactokinase 2
chr2_-_183387064 0.30 ENST00000536095.1
ENST00000331935.6
ENST00000358139.2
ENST00000456212.1
phosphodiesterase 1A, calmodulin-dependent
chr7_+_100026406 0.30 ENST00000414441.1
methylphosphate capping enzyme
chr15_-_54267147 0.30 ENST00000558866.1
ENST00000558920.1
RP11-643A5.2
chr17_-_49124230 0.29 ENST00000510283.1
ENST00000510855.1
sperm associated antigen 9
chr1_+_170632250 0.29 ENST00000367760.3
paired related homeobox 1
chr12_-_10978957 0.29 ENST00000240619.2
taste receptor, type 2, member 10
chr2_-_183387430 0.28 ENST00000410103.1
phosphodiesterase 1A, calmodulin-dependent
chr12_-_100486668 0.28 ENST00000550544.1
ENST00000551980.1
ENST00000548045.1
ENST00000545232.2
ENST00000551973.1
UHRF1 binding protein 1-like
chr12_-_49582978 0.28 ENST00000301071.7
tubulin, alpha 1a
chr17_+_17685422 0.27 ENST00000395774.1
retinoic acid induced 1
chr10_-_128975273 0.27 ENST00000424811.2
family with sequence similarity 196, member A
chr3_-_129513259 0.27 ENST00000329333.5
transmembrane and coiled-coil domain family 1
chr18_-_31803169 0.27 ENST00000590712.1
nucleolar protein 4
chr22_+_40322623 0.26 ENST00000399090.2
GRB2-related adaptor protein 2
chr5_+_61874696 0.26 ENST00000491184.2
leucine rich repeat containing 70
chr16_+_31366455 0.26 ENST00000268296.4
integrin, alpha X (complement component 3 receptor 4 subunit)
chr12_-_6798523 0.26 ENST00000319770.3
zinc finger protein 384
chr2_+_179318295 0.25 ENST00000442710.1
deafness, autosomal recessive 59
chr22_+_17956618 0.25 ENST00000262608.8
cat eye syndrome chromosome region, candidate 2
chr1_+_149239529 0.24 ENST00000457216.2
RP11-403I13.4
chr12_+_54366894 0.23 ENST00000546378.1
ENST00000243082.4
homeobox C11
chr2_+_47454054 0.23 ENST00000426892.1
AC106869.2
chr18_+_61575200 0.23 ENST00000238508.3
serpin peptidase inhibitor, clade B (ovalbumin), member 10
chr17_+_18759612 0.23 ENST00000432893.2
ENST00000414602.1
ENST00000574522.1
ENST00000570450.1
ENST00000419071.2
phosphoribosyl pyrophosphate synthetase-associated protein 2
chr11_+_36317830 0.22 ENST00000530639.1
proline rich 5 like
chr5_+_157158205 0.22 ENST00000231198.7
tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)
chr22_+_40322595 0.22 ENST00000420971.1
ENST00000544756.1
GRB2-related adaptor protein 2
chr3_-_52860850 0.22 ENST00000441637.2
inter-alpha-trypsin inhibitor heavy chain family, member 4
chr2_+_65663812 0.22 ENST00000606978.1
ENST00000377977.3
ENST00000536804.1
AC074391.1
chr17_-_50236039 0.21 ENST00000451037.2
carbonic anhydrase X
chrX_-_39956656 0.21 ENST00000397354.3
ENST00000378444.4
BCL6 corepressor
chr16_+_24621546 0.21 ENST00000566108.1
CTD-2540M10.1
chrX_+_41548220 0.21 ENST00000378142.4
G protein-coupled receptor 34
chr10_-_128210005 0.21 ENST00000284694.7
ENST00000454341.1
ENST00000432642.1
ENST00000392694.1
chromosome 10 open reading frame 90

Network of associatons between targets according to the STRING database.

First level regulatory network of POU4F1_POU4F3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 3.0 GO:0042264 peptidyl-aspartic acid hydroxylation(GO:0042264)
0.7 4.0 GO:0010760 negative regulation of macrophage chemotaxis(GO:0010760)
0.6 3.1 GO:0010730 negative regulation of hydrogen peroxide biosynthetic process(GO:0010730) positive regulation of skeletal muscle satellite cell proliferation(GO:1902724) positive regulation of growth factor dependent skeletal muscle satellite cell proliferation(GO:1902728)
0.6 8.5 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.6 1.7 GO:1902396 protein localization to bicellular tight junction(GO:1902396)
0.5 6.4 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.4 3.0 GO:1903976 negative regulation of glial cell migration(GO:1903976)
0.3 1.0 GO:0071314 cellular response to cocaine(GO:0071314)
0.3 2.4 GO:0042078 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.3 1.3 GO:0048390 apoptotic process involved in endocardial cushion morphogenesis(GO:0003277) intermediate mesoderm morphogenesis(GO:0048390) intermediate mesoderm formation(GO:0048391) intermediate mesodermal cell differentiation(GO:0048392) regulation of cardiac muscle fiber development(GO:0055018) positive regulation of cardiac muscle fiber development(GO:0055020) bud dilation involved in lung branching(GO:0060503) BMP signaling pathway involved in ureter morphogenesis(GO:0061149) renal system segmentation(GO:0061150) BMP signaling pathway involved in renal system segmentation(GO:0061151) pulmonary artery endothelial tube morphogenesis(GO:0061155) regulation of transcription from RNA polymerase II promoter involved in mesonephros development(GO:0061216) BMP signaling pathway involved in nephric duct formation(GO:0071893) negative regulation of branch elongation involved in ureteric bud branching(GO:0072096) negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway(GO:0072097) anterior/posterior pattern specification involved in ureteric bud development(GO:0072099) specification of ureteric bud anterior/posterior symmetry(GO:0072100) specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway(GO:0072101) ureter epithelial cell differentiation(GO:0072192) negative regulation of mesenchymal cell proliferation involved in ureter development(GO:0072200) positive regulation of cell proliferation involved in outflow tract morphogenesis(GO:1901964) cardiac jelly development(GO:1905072) regulation of metanephric S-shaped body morphogenesis(GO:2000004) negative regulation of metanephric S-shaped body morphogenesis(GO:2000005) regulation of metanephric comma-shaped body morphogenesis(GO:2000006) negative regulation of metanephric comma-shaped body morphogenesis(GO:2000007)
0.2 0.6 GO:0046013 regulation of T cell homeostatic proliferation(GO:0046013)
0.2 0.8 GO:0046035 CMP salvage(GO:0006238) CMP biosynthetic process(GO:0009224) CMP metabolic process(GO:0046035)
0.2 0.9 GO:0002378 immunoglobulin biosynthetic process(GO:0002378) hematopoietic stem cell migration(GO:0035701)
0.1 0.9 GO:0098746 fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746)
0.1 0.8 GO:0001757 somite specification(GO:0001757)
0.1 1.5 GO:0018317 protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.1 1.5 GO:0071787 endoplasmic reticulum tubular network assembly(GO:0071787)
0.1 0.4 GO:0033058 directional locomotion(GO:0033058)
0.1 0.4 GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287)
0.1 4.0 GO:0006337 nucleosome disassembly(GO:0006337)
0.1 3.9 GO:0044458 motile cilium assembly(GO:0044458)
0.1 0.3 GO:0035526 retrograde transport, plasma membrane to Golgi(GO:0035526)
0.1 1.1 GO:0097500 receptor localization to nonmotile primary cilium(GO:0097500)
0.1 1.6 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.1 2.0 GO:0072257 metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307)
0.1 0.5 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
0.1 2.2 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.1 0.6 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.1 0.5 GO:0010133 proline catabolic process to glutamate(GO:0010133)
0.1 0.5 GO:0090292 nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.1 0.3 GO:0061743 motor learning(GO:0061743)
0.1 1.5 GO:0070129 regulation of mitochondrial translation(GO:0070129)
0.1 0.4 GO:0038112 interleukin-8-mediated signaling pathway(GO:0038112)
0.1 0.3 GO:1901805 beta-glucoside metabolic process(GO:1901804) beta-glucoside catabolic process(GO:1901805) positive regulation of neuronal action potential(GO:1904457)
0.1 1.1 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091)
0.1 0.2 GO:2000870 regulation of progesterone secretion(GO:2000870)
0.1 1.1 GO:0061635 regulation of protein complex stability(GO:0061635)
0.1 0.6 GO:0019509 L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.1 2.3 GO:0048268 clathrin coat assembly(GO:0048268)
0.1 0.9 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.1 0.5 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.1 0.2 GO:0000415 negative regulation of histone H3-K36 methylation(GO:0000415)
0.1 3.7 GO:0010765 positive regulation of sodium ion transport(GO:0010765)
0.1 0.3 GO:0046121 deoxyribonucleoside catabolic process(GO:0046121)
0.1 0.2 GO:1900369 negative regulation of RNA interference(GO:1900369)
0.0 0.3 GO:0061034 olfactory bulb mitral cell layer development(GO:0061034)
0.0 0.9 GO:2001032 regulation of double-strand break repair via nonhomologous end joining(GO:2001032)
0.0 2.6 GO:0006739 NADP metabolic process(GO:0006739)
0.0 0.8 GO:0046069 cGMP catabolic process(GO:0046069)
0.0 0.7 GO:0001514 selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.0 2.9 GO:0008347 glial cell migration(GO:0008347)
0.0 0.2 GO:0042256 mature ribosome assembly(GO:0042256) assembly of large subunit precursor of preribosome(GO:1902626)
0.0 1.2 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 0.4 GO:1900165 negative regulation of interleukin-6 secretion(GO:1900165)
0.0 5.9 GO:0098869 cellular oxidant detoxification(GO:0098869)
0.0 1.0 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.0 0.3 GO:1903608 protein localization to cytoplasmic stress granule(GO:1903608)
0.0 0.3 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.0 0.3 GO:0090074 negative regulation of protein homodimerization activity(GO:0090074)
0.0 0.7 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.0 1.0 GO:0006825 copper ion transport(GO:0006825)
0.0 1.7 GO:0006506 GPI anchor metabolic process(GO:0006505) GPI anchor biosynthetic process(GO:0006506)
0.0 0.1 GO:0070898 RNA polymerase III transcriptional preinitiation complex assembly(GO:0070898)
0.0 0.3 GO:0040031 snRNA modification(GO:0040031)
0.0 0.3 GO:0048664 neuron fate determination(GO:0048664)
0.0 0.1 GO:0000117 regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0000117)
0.0 0.2 GO:0070383 DNA cytosine deamination(GO:0070383)
0.0 0.2 GO:0007296 vitellogenesis(GO:0007296)
0.0 1.0 GO:0019228 neuronal action potential(GO:0019228)
0.0 0.4 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.0 0.0 GO:0010727 negative regulation of hydrogen peroxide metabolic process(GO:0010727)
0.0 1.7 GO:0032781 positive regulation of ATPase activity(GO:0032781)
0.0 0.2 GO:0060272 embryonic skeletal joint morphogenesis(GO:0060272)
0.0 0.1 GO:0060005 vestibular reflex(GO:0060005)
0.0 0.9 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 2.1 GO:0006970 response to osmotic stress(GO:0006970)
0.0 0.2 GO:0090160 Golgi to lysosome transport(GO:0090160)
0.0 1.5 GO:0048207 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.0 0.3 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.0 0.3 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.0 0.0 GO:0002755 MyD88-dependent toll-like receptor signaling pathway(GO:0002755)
0.0 0.3 GO:0006012 galactose metabolic process(GO:0006012)
0.0 0.2 GO:0038203 TORC2 signaling(GO:0038203)
0.0 0.5 GO:0007417 central nervous system development(GO:0007417)
0.0 1.0 GO:0016445 somatic diversification of immunoglobulins(GO:0016445)
0.0 0.1 GO:0098722 asymmetric stem cell division(GO:0098722)
0.0 0.6 GO:0000387 spliceosomal snRNP assembly(GO:0000387)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 3.9 GO:0005579 membrane attack complex(GO:0005579)
0.3 1.0 GO:0097124 cyclin A2-CDK2 complex(GO:0097124)
0.3 2.8 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.2 6.0 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 2.2 GO:0071439 clathrin complex(GO:0071439)
0.1 1.7 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.1 0.8 GO:0035032 phosphatidylinositol 3-kinase complex, class III(GO:0035032)
0.1 0.9 GO:0060200 clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
0.1 0.9 GO:0031985 Golgi cisterna(GO:0031985)
0.1 0.5 GO:1990246 uniplex complex(GO:1990246)
0.1 2.5 GO:0043194 axon initial segment(GO:0043194)
0.1 1.1 GO:0034464 BBSome(GO:0034464)
0.1 0.8 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.1 1.3 GO:0030008 TRAPP complex(GO:0030008)
0.1 1.1 GO:0005828 kinetochore microtubule(GO:0005828)
0.1 0.6 GO:0000439 core TFIIH complex(GO:0000439)
0.1 0.2 GO:0002189 ribose phosphate diphosphokinase complex(GO:0002189)
0.1 0.6 GO:0097504 Gemini of coiled bodies(GO:0097504)
0.0 0.7 GO:0043190 ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.0 1.7 GO:0031143 pseudopodium(GO:0031143)
0.0 1.4 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.0 3.6 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 1.0 GO:0000974 Prp19 complex(GO:0000974)
0.0 0.3 GO:0097165 nuclear stress granule(GO:0097165)
0.0 0.7 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 0.2 GO:0044530 supraspliceosomal complex(GO:0044530)
0.0 3.1 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 0.5 GO:0034992 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 4.3 GO:0031225 anchored component of membrane(GO:0031225)
0.0 1.5 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 0.4 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 1.5 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 0.2 GO:0031010 ISWI-type complex(GO:0031010)
0.0 0.2 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.0 0.1 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.0 0.7 GO:0030424 axon(GO:0030424)
0.0 1.5 GO:0005761 organellar ribosome(GO:0000313) mitochondrial ribosome(GO:0005761)
0.0 0.2 GO:0031089 platelet dense granule lumen(GO:0031089)
0.0 2.3 GO:0005882 intermediate filament(GO:0005882)
0.0 1.2 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.3 GO:0090545 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 0.1 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.0 0.4 GO:0042629 mast cell granule(GO:0042629)
0.0 2.4 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 3.0 GO:0004597 peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.9 2.6 GO:0052857 NADHX epimerase activity(GO:0052856) NADPHX epimerase activity(GO:0052857)
0.5 6.4 GO:0050694 galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
0.3 3.1 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.2 9.3 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.2 0.6 GO:0010309 acireductone dioxygenase [iron(II)-requiring] activity(GO:0010309)
0.2 5.9 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.2 3.9 GO:0003688 DNA replication origin binding(GO:0003688)
0.1 2.3 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.1 0.5 GO:0004657 proline dehydrogenase activity(GO:0004657)
0.1 0.3 GO:0004139 deoxyribose-phosphate aldolase activity(GO:0004139)
0.1 0.3 GO:0033858 N-acetylgalactosamine kinase activity(GO:0033858)
0.1 3.8 GO:0008009 chemokine activity(GO:0008009)
0.1 1.3 GO:0070700 BMP receptor binding(GO:0070700)
0.1 0.7 GO:0004800 thyroxine 5'-deiodinase activity(GO:0004800)
0.1 0.9 GO:0030348 syntaxin-3 binding(GO:0030348)
0.1 1.0 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.1 0.6 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.1 0.2 GO:0008193 tRNA guanylyltransferase activity(GO:0008193)
0.1 0.8 GO:0004849 uridine kinase activity(GO:0004849)
0.1 0.4 GO:0004918 interleukin-8 receptor activity(GO:0004918)
0.1 0.3 GO:0070052 collagen V binding(GO:0070052)
0.1 1.6 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.1 0.3 GO:0004348 glucosylceramidase activity(GO:0004348)
0.0 2.4 GO:0001671 ATPase activator activity(GO:0001671)
0.0 0.8 GO:0008565 protein transporter activity(GO:0008565)
0.0 0.5 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.0 0.5 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0 0.3 GO:0050682 AF-2 domain binding(GO:0050682)
0.0 1.4 GO:0000030 mannosyltransferase activity(GO:0000030)
0.0 3.0 GO:0008146 sulfotransferase activity(GO:0008146)
0.0 0.2 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
0.0 1.0 GO:0005248 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0 0.1 GO:0000992 polymerase III regulatory region sequence-specific DNA binding(GO:0000992) RNA polymerase III type 1 promoter sequence-specific DNA binding(GO:0001002) RNA polymerase III type 2 promoter sequence-specific DNA binding(GO:0001003)
0.0 0.2 GO:0003726 double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0 2.7 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 0.7 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.0 0.4 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.0 0.3 GO:0070915 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.0 0.2 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.0 0.9 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 0.4 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 0.1 GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097199)
0.0 0.3 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.0 1.2 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.0 0.2 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
0.0 0.6 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.5 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 0.6 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 0.1 GO:0004911 interleukin-2 receptor activity(GO:0004911) interleukin-2 binding(GO:0019976)
0.0 0.5 GO:0005521 lamin binding(GO:0005521)
0.0 6.5 GO:0030246 carbohydrate binding(GO:0030246)
0.0 0.3 GO:0001608 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 1.0 GO:0097472 cyclin-dependent protein kinase activity(GO:0097472)
0.0 0.3 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.1 ST STAT3 PATHWAY STAT3 Pathway
0.1 5.9 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 1.0 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 1.9 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 3.5 PID NOTCH PATHWAY Notch signaling pathway
0.0 0.5 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 1.3 PID BMP PATHWAY BMP receptor signaling
0.0 1.5 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.0 0.9 PID RHOA PATHWAY RhoA signaling pathway
0.0 0.9 SIG PIP3 SIGNALING IN B LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.0 0.4 ST GRANULE CELL SURVIVAL PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0 0.9 SIG CD40PATHWAYMAP Genes related to CD40 signaling
0.0 0.6 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions
0.0 3.7 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.1 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.1 6.5 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.1 7.5 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.1 6.7 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.1 3.9 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.1 0.8 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.1 2.5 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 2.0 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 0.9 REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.0 1.7 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.0 1.0 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0 0.9 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 0.7 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.0 1.0 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 0.6 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.8 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.0 0.2 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0 0.8 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 0.6 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 0.4 REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0 0.5 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 0.3 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 2.0 REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.0 1.0 REACTOME METABOLISM OF NON CODING RNA Genes involved in Metabolism of non-coding RNA