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SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for POU4F2

Z-value: 0.29

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Transcription factors associated with POU4F2

Gene Symbol Gene ID Gene Info
POU4F2
ENSG00000151615.3 POU class 4 homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
POU4F2hg19_v2_chr4_+_147560042_1475600460.282.3e-01Click!

Activity profile of POU4F2 motif

Sorted Z-values of POU4F2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr6_-_111136299 0.45 ENST00000457688.1
CDK19
cyclin-dependent kinase 19
chr4_+_141264597 0.43 ENST00000338517.4
ENST00000394203.3
ENST00000506322.1
SCOC
short coiled-coil protein
chr12_+_64798826 0.37 ENST00000540203.1
XPOT
exportin, tRNA
chr17_+_61151306 0.33 ENST00000580068.1
ENST00000580466.1
TANC2
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
chr5_-_58295712 0.30 ENST00000317118.8
PDE4D
phosphodiesterase 4D, cAMP-specific
chr14_-_51027838 0.28 ENST00000555216.1
MAP4K5
mitogen-activated protein kinase kinase kinase kinase 5
chr2_+_44502630 0.26 ENST00000410056.3
ENST00000409741.1
ENST00000409229.3
SLC3A1
solute carrier family 3 (amino acid transporter heavy chain), member 1
chr20_+_48909240 0.26 ENST00000371639.3
RP11-290F20.1
RP11-290F20.1
chr8_-_18541603 0.26 ENST00000428502.2
PSD3
pleckstrin and Sec7 domain containing 3
chr2_+_44502597 0.25 ENST00000260649.6
ENST00000409387.1
SLC3A1
solute carrier family 3 (amino acid transporter heavy chain), member 1
chr9_-_5830768 0.25 ENST00000381506.3
ERMP1
endoplasmic reticulum metallopeptidase 1
chr17_-_33390667 0.23 ENST00000378516.2
ENST00000268850.7
ENST00000394597.2
RFFL
ring finger and FYVE-like domain containing E3 ubiquitin protein ligase
chr1_+_66820058 0.22 ENST00000480109.2
PDE4B
phosphodiesterase 4B, cAMP-specific
chr2_+_191792376 0.21 ENST00000409428.1
ENST00000409215.1
GLS
glutaminase
chr8_-_131399110 0.20 ENST00000521426.1
ASAP1
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
chr11_-_107729287 0.20 ENST00000375682.4
SLC35F2
solute carrier family 35, member F2
chr11_-_107729504 0.20 ENST00000265836.7
SLC35F2
solute carrier family 35, member F2
chr11_-_115127611 0.20 ENST00000545094.1
CADM1
cell adhesion molecule 1
chr12_-_118796971 0.19 ENST00000542902.1
TAOK3
TAO kinase 3
chr4_+_169418255 0.19 ENST00000505667.1
ENST00000511948.1
PALLD
palladin, cytoskeletal associated protein
chr1_-_193028426 0.19 ENST00000367450.3
ENST00000530098.2
ENST00000367451.4
ENST00000367448.1
ENST00000367449.1
UCHL5
ubiquitin carboxyl-terminal hydrolase L5
chr1_+_193028717 0.19 ENST00000415442.2
ENST00000506303.1
TROVE2
TROVE domain family, member 2
chr2_+_172309634 0.18 ENST00000339506.3
DCAF17
DDB1 and CUL4 associated factor 17
chr12_+_109577202 0.18 ENST00000377848.3
ENST00000377854.5
ACACB
acetyl-CoA carboxylase beta
chr4_-_169401628 0.17 ENST00000514748.1
ENST00000512371.1
ENST00000260184.7
ENST00000505890.1
ENST00000511577.1
DDX60L
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like
chr12_-_118796910 0.16 ENST00000541186.1
ENST00000539872.1
TAOK3
TAO kinase 3
chr1_-_193028632 0.16 ENST00000421683.1
UCHL5
ubiquitin carboxyl-terminal hydrolase L5
chr4_+_169418195 0.16 ENST00000261509.6
ENST00000335742.7
PALLD
palladin, cytoskeletal associated protein
chr6_-_111136513 0.15 ENST00000368911.3
CDK19
cyclin-dependent kinase 19
chr16_+_19421803 0.15 ENST00000541464.1
TMC5
transmembrane channel-like 5
chr1_+_40506255 0.15 ENST00000421589.1
CAP1
CAP, adenylate cyclase-associated protein 1 (yeast)
chr16_+_19422035 0.15 ENST00000381414.4
ENST00000396229.2
TMC5
transmembrane channel-like 5
chr6_-_111804905 0.14 ENST00000358835.3
ENST00000435970.1
REV3L
REV3-like, polymerase (DNA directed), zeta, catalytic subunit
chr1_-_193028621 0.14 ENST00000367455.4
ENST00000367454.1
UCHL5
ubiquitin carboxyl-terminal hydrolase L5
chr1_+_193028552 0.14 ENST00000400968.2
ENST00000432079.1
TROVE2
TROVE domain family, member 2
chr17_+_73539339 0.13 ENST00000581713.1
LLGL2
lethal giant larvae homolog 2 (Drosophila)
chr20_+_5987890 0.13 ENST00000378868.4
CRLS1
cardiolipin synthase 1
chr6_+_10521574 0.13 ENST00000495262.1
GCNT2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
chr11_-_795286 0.13 ENST00000533385.1
ENST00000527723.1
SLC25A22
solute carrier family 25 (mitochondrial carrier: glutamate), member 22
chr5_+_102200948 0.13 ENST00000511477.1
ENST00000506006.1
ENST00000509832.1
PAM
peptidylglycine alpha-amidating monooxygenase
chr9_-_37384431 0.12 ENST00000452923.1
RP11-397D12.4
RP11-397D12.4
chr1_-_44482979 0.12 ENST00000360584.2
ENST00000357730.2
ENST00000528803.1
SLC6A9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr5_-_87516448 0.11 ENST00000511218.1
TMEM161B
transmembrane protein 161B
chr10_+_123951957 0.11 ENST00000514539.1
TACC2
transforming, acidic coiled-coil containing protein 2
chr11_-_795170 0.11 ENST00000481290.1
SLC25A22
solute carrier family 25 (mitochondrial carrier: glutamate), member 22
chr11_+_31531291 0.11 ENST00000350638.5
ENST00000379163.5
ENST00000395934.2
ELP4
elongator acetyltransferase complex subunit 4
chr14_-_70883708 0.10 ENST00000256366.4
SYNJ2BP
synaptojanin 2 binding protein
chr1_+_40506392 0.10 ENST00000414893.1
ENST00000414281.1
ENST00000420216.1
ENST00000372792.2
ENST00000372798.1
ENST00000340450.3
ENST00000372805.3
ENST00000435719.1
ENST00000427843.1
ENST00000417287.1
ENST00000424977.1
ENST00000446031.1
CAP1
CAP, adenylate cyclase-associated protein 1 (yeast)
chr10_-_116444371 0.10 ENST00000533213.2
ENST00000369252.4
ABLIM1
actin binding LIM protein 1
chr15_-_37393406 0.10 ENST00000338564.5
ENST00000558313.1
ENST00000340545.5
MEIS2
Meis homeobox 2
chr9_-_14308004 0.09 ENST00000493697.1
NFIB
nuclear factor I/B
chr16_-_69390209 0.09 ENST00000563634.1
RP11-343C2.9
Uncharacterized protein
chr19_-_10446449 0.09 ENST00000592439.1
ICAM3
intercellular adhesion molecule 3
chr13_+_36050881 0.08 ENST00000537702.1
NBEA
neurobeachin
chr12_+_79371565 0.08 ENST00000551304.1
SYT1
synaptotagmin I
chr17_-_38956205 0.07 ENST00000306658.7
KRT28
keratin 28
chr6_-_74231444 0.07 ENST00000331523.2
ENST00000356303.2
EEF1A1
eukaryotic translation elongation factor 1 alpha 1
chr2_-_70780572 0.06 ENST00000450929.1
TGFA
transforming growth factor, alpha
chr16_+_28505955 0.06 ENST00000564831.1
ENST00000328423.5
ENST00000431282.1
APOBR
apolipoprotein B receptor
chr1_-_31666767 0.06 ENST00000530145.1
NKAIN1
Na+/K+ transporting ATPase interacting 1
chrX_-_99987088 0.06 ENST00000372981.1
ENST00000263033.5
SYTL4
synaptotagmin-like 4
chr14_+_32030582 0.06 ENST00000550649.1
ENST00000281081.7
NUBPL
nucleotide binding protein-like
chr1_-_47655686 0.05 ENST00000294338.2
PDZK1IP1
PDZK1 interacting protein 1
chr10_-_21186144 0.05 ENST00000377119.1
NEBL
nebulette
chr2_-_122262593 0.05 ENST00000418989.1
CLASP1
cytoplasmic linker associated protein 1
chrX_+_139791917 0.05 ENST00000607004.1
ENST00000370535.3
LINC00632
long intergenic non-protein coding RNA 632
chr14_-_90085458 0.04 ENST00000345097.4
ENST00000555855.1
ENST00000555353.1
FOXN3
forkhead box N3
chr3_-_58613323 0.04 ENST00000474531.1
ENST00000465970.1
FAM107A
family with sequence similarity 107, member A
chr11_-_31531121 0.04 ENST00000532287.1
ENST00000526776.1
ENST00000534812.1
ENST00000529749.1
ENST00000278200.1
ENST00000530023.1
ENST00000533642.1
IMMP1L
IMP1 inner mitochondrial membrane peptidase-like (S. cerevisiae)
chr11_-_96076334 0.04 ENST00000524717.1
MAML2
mastermind-like 2 (Drosophila)
chr3_+_159557637 0.04 ENST00000445224.2
SCHIP1
schwannomin interacting protein 1
chr17_-_39623681 0.04 ENST00000225899.3
KRT32
keratin 32
chr8_+_97773202 0.04 ENST00000519484.1
CPQ
carboxypeptidase Q
chr20_-_50418972 0.04 ENST00000395997.3
SALL4
spalt-like transcription factor 4
chr7_+_142919130 0.03 ENST00000408947.3
TAS2R40
taste receptor, type 2, member 40
chr17_+_18086392 0.03 ENST00000541285.1
ALKBH5
alkB, alkylation repair homolog 5 (E. coli)
chr17_-_64225508 0.03 ENST00000205948.6
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr11_-_125550726 0.03 ENST00000315608.3
ENST00000530048.1
ACRV1
acrosomal vesicle protein 1
chr2_+_54951679 0.02 ENST00000356458.6
EML6
echinoderm microtubule associated protein like 6
chr12_-_118797475 0.02 ENST00000541786.1
ENST00000419821.2
ENST00000541878.1
TAOK3
TAO kinase 3
chr21_+_17443521 0.02 ENST00000456342.1
LINC00478
long intergenic non-protein coding RNA 478
chr22_-_28490123 0.02 ENST00000442232.1
TTC28
tetratricopeptide repeat domain 28
chr15_-_98417780 0.02 ENST00000503874.3
LINC00923
long intergenic non-protein coding RNA 923
chr6_+_4087664 0.02 ENST00000430835.2
C6orf201
chromosome 6 open reading frame 201
chr20_-_50419055 0.02 ENST00000217086.4
SALL4
spalt-like transcription factor 4
chr12_+_53848549 0.02 ENST00000439930.3
ENST00000548933.1
ENST00000562264.1
PCBP2
poly(rC) binding protein 2
chr17_-_7832753 0.02 ENST00000303790.2
KCNAB3
potassium voltage-gated channel, shaker-related subfamily, beta member 3
chr3_+_50230105 0.02 ENST00000440836.1
GNAT1
guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1
chr12_+_53848505 0.02 ENST00000552819.1
ENST00000455667.3
PCBP2
poly(rC) binding protein 2
chr6_+_49518113 0.02 ENST00000529246.2
C6orf141
chromosome 6 open reading frame 141
chr1_-_190446759 0.02 ENST00000367462.3
BRINP3
bone morphogenetic protein/retinoic acid inducible neural-specific 3
chr1_+_109265033 0.02 ENST00000445274.1
FNDC7
fibronectin type III domain containing 7
chr14_+_38033252 0.01 ENST00000554829.1
RP11-356O9.1
RP11-356O9.1
chr11_-_107729887 0.01 ENST00000525815.1
SLC35F2
solute carrier family 35, member F2
chr10_+_99205894 0.01 ENST00000370854.3
ENST00000393760.1
ENST00000414567.1
ENST00000370846.4
ZDHHC16
zinc finger, DHHC-type containing 16
chr2_-_198540751 0.01 ENST00000429081.1
RFTN2
raftlin family member 2
chr17_-_9929581 0.01 ENST00000437099.2
ENST00000396115.2
GAS7
growth arrest-specific 7
chr4_+_159442878 0.01 ENST00000307765.5
ENST00000423548.1
RXFP1
relaxin/insulin-like family peptide receptor 1
chr8_+_97773457 0.01 ENST00000521142.1
CPQ
carboxypeptidase Q

Network of associatons between targets according to the STRING database.

First level regulatory network of POU4F2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0015811 L-cystine transport(GO:0015811)
0.0 0.1 GO:0061536 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.0 0.2 GO:2001271 negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.0 0.5 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 0.2 GO:1903527 positive regulation of membrane tubulation(GO:1903527)
0.0 0.2 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.0 0.2 GO:0006543 glutamine catabolic process(GO:0006543)
0.0 0.2 GO:2001295 malonyl-CoA biosynthetic process(GO:2001295)
0.0 0.4 GO:0061635 regulation of protein complex stability(GO:0061635)
0.0 0.1 GO:0018032 protein amidation(GO:0018032)
0.0 0.5 GO:0048853 forebrain morphogenesis(GO:0048853)
0.0 0.1 GO:0036438 maintenance of lens transparency(GO:0036438)
0.0 0.1 GO:1904386 response to thyroxine(GO:0097068) response to L-phenylalanine derivative(GO:1904386)
0.0 0.1 GO:0098746 fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746)
0.0 0.4 GO:0003334 keratinocyte development(GO:0003334)
0.0 0.4 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.0 0.1 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0002947 tumor necrosis factor receptor superfamily complex(GO:0002947)
0.0 0.1 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.0 0.5 GO:0031597 cytosolic proteasome complex(GO:0031597)
0.0 0.0 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.0 0.0 GO:0031592 centrosomal corona(GO:0031592)
0.0 0.6 GO:0016592 mediator complex(GO:0016592)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0015184 L-cystine transmembrane transporter activity(GO:0015184)
0.0 0.1 GO:0030572 cardiolipin synthase activity(GO:0008808) phosphatidyltransferase activity(GO:0030572) CDP-diacylglycerol-phosphatidylglycerol phosphatidyltransferase activity(GO:0043337)
0.0 0.3 GO:0030620 U2 snRNA binding(GO:0030620)
0.0 0.2 GO:0003989 acetyl-CoA carboxylase activity(GO:0003989)
0.0 0.1 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.0 0.2 GO:0004359 glutaminase activity(GO:0004359)
0.0 0.1 GO:0004598 peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598)
0.0 0.2 GO:0005280 hydrogen:amino acid symporter activity(GO:0005280)
0.0 0.5 GO:0070628 proteasome binding(GO:0070628)
0.0 0.1 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0 0.3 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)
0.0 0.3 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 0.3 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 0.4 GO:0051371 muscle alpha-actinin binding(GO:0051371)