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SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for POU6F1

Z-value: 0.50

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Transcription factors associated with POU6F1

Gene Symbol Gene ID Gene Info
POU6F1
ENSG00000184271.11 POU class 6 homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
POU6F1hg19_v2_chr12_-_51611477_51611612-0.492.8e-02Click!

Activity profile of POU6F1 motif

Sorted Z-values of POU6F1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_153538292 1.24 ENST00000497140.1
ENST00000368708.3
S100A2
S100 calcium binding protein A2
chr18_+_61554932 1.17 ENST00000299502.4
ENST00000457692.1
ENST00000413956.1
SERPINB2
serpin peptidase inhibitor, clade B (ovalbumin), member 2
chr17_-_39677971 1.08 ENST00000393976.2
KRT15
keratin 15
chr7_-_83824449 0.99 ENST00000420047.1
SEMA3A
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr4_+_106631966 0.97 ENST00000360505.5
ENST00000510865.1
ENST00000509336.1
GSTCD
glutathione S-transferase, C-terminal domain containing
chr7_-_30008849 0.80 ENST00000409497.1
SCRN1
secernin 1
chr13_+_98612446 0.76 ENST00000496368.1
ENST00000421861.2
ENST00000357602.3
IPO5
importin 5
chr1_-_161008697 0.67 ENST00000318289.10
ENST00000368023.3
ENST00000368024.1
ENST00000423014.2
TSTD1
thiosulfate sulfurtransferase (rhodanese)-like domain containing 1
chr21_-_34915123 0.65 ENST00000438059.1
GART
phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
chr13_-_52027134 0.60 ENST00000311234.4
ENST00000425000.1
ENST00000463928.1
ENST00000442263.3
ENST00000398119.2
INTS6
integrator complex subunit 6
chr6_-_47010061 0.59 ENST00000371253.2
GPR110
G protein-coupled receptor 110
chr15_+_59279851 0.58 ENST00000348370.4
ENST00000434298.1
ENST00000559160.1
RNF111
ring finger protein 111
chrX_+_43515467 0.57 ENST00000338702.3
ENST00000542639.1
MAOA
monoamine oxidase A
chr16_+_15744078 0.57 ENST00000396354.1
ENST00000570727.1
NDE1
nudE neurodevelopment protein 1
chr5_+_67586465 0.57 ENST00000336483.5
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr6_+_110501621 0.55 ENST00000368930.1
ENST00000307731.1
CDC40
cell division cycle 40
chr6_-_47009996 0.52 ENST00000371243.2
GPR110
G protein-coupled receptor 110
chr4_+_123161120 0.50 ENST00000446180.1
KIAA1109
KIAA1109
chr7_-_83824169 0.50 ENST00000265362.4
SEMA3A
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr19_-_58662139 0.49 ENST00000598312.1
ZNF329
zinc finger protein 329
chr14_-_70883708 0.47 ENST00000256366.4
SYNJ2BP
synaptojanin 2 binding protein
chr11_-_107729504 0.46 ENST00000265836.7
SLC35F2
solute carrier family 35, member F2
chr4_-_83812157 0.45 ENST00000513323.1
SEC31A
SEC31 homolog A (S. cerevisiae)
chr9_-_13165457 0.45 ENST00000542239.1
ENST00000538841.1
ENST00000433359.2
MPDZ
multiple PDZ domain protein
chr6_-_110501200 0.44 ENST00000392586.1
ENST00000419252.1
ENST00000392589.1
ENST00000392588.1
ENST00000359451.2
WASF1
WAS protein family, member 1
chr20_+_58515417 0.43 ENST00000360816.3
FAM217B
family with sequence similarity 217, member B
chr15_-_31283618 0.42 ENST00000563714.1
MTMR10
myotubularin related protein 10
chrX_+_102024075 0.41 ENST00000431616.1
ENST00000440496.1
ENST00000420471.1
ENST00000435966.1
LINC00630
long intergenic non-protein coding RNA 630
chr12_+_102513950 0.41 ENST00000378128.3
ENST00000327680.2
ENST00000541394.1
ENST00000543784.1
PARPBP
PARP1 binding protein
chr11_-_107729287 0.41 ENST00000375682.4
SLC35F2
solute carrier family 35, member F2
chr18_+_52495426 0.41 ENST00000262094.5
RAB27B
RAB27B, member RAS oncogene family
chr6_+_110501344 0.40 ENST00000368932.1
CDC40
cell division cycle 40
chr11_+_12302492 0.38 ENST00000533534.1
MICALCL
MICAL C-terminal like
chr9_+_131644398 0.38 ENST00000372599.3
LRRC8A
leucine rich repeat containing 8 family, member A
chr16_-_58718638 0.36 ENST00000562397.1
ENST00000564010.1
ENST00000570214.1
ENST00000563196.1
SLC38A7
solute carrier family 38, member 7
chr13_+_49551020 0.34 ENST00000541916.1
FNDC3A
fibronectin type III domain containing 3A
chr9_+_131644388 0.33 ENST00000372600.4
LRRC8A
leucine rich repeat containing 8 family, member A
chr12_+_102514019 0.33 ENST00000537257.1
ENST00000358383.5
ENST00000392911.2
PARPBP
PARP1 binding protein
chr4_-_76912070 0.31 ENST00000395711.4
ENST00000356260.5
SDAD1
SDA1 domain containing 1
chr6_-_110501126 0.30 ENST00000368938.1
WASF1
WAS protein family, member 1
chr6_-_111136299 0.29 ENST00000457688.1
CDK19
cyclin-dependent kinase 19
chr1_-_197115818 0.29 ENST00000367409.4
ENST00000294732.7
ASPM
asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
chr12_-_108954933 0.29 ENST00000431469.2
ENST00000546815.1
SART3
squamous cell carcinoma antigen recognized by T cells 3
chr6_-_111804905 0.28 ENST00000358835.3
ENST00000435970.1
REV3L
REV3-like, polymerase (DNA directed), zeta, catalytic subunit
chr18_+_9475001 0.27 ENST00000019317.4
RALBP1
ralA binding protein 1
chr5_+_115177178 0.26 ENST00000316788.7
AP3S1
adaptor-related protein complex 3, sigma 1 subunit
chr6_-_74231444 0.25 ENST00000331523.2
ENST00000356303.2
EEF1A1
eukaryotic translation elongation factor 1 alpha 1
chr17_-_26972126 0.23 ENST00000528896.2
KIAA0100
KIAA0100
chr12_-_95397442 0.23 ENST00000547157.1
ENST00000547986.1
ENST00000327772.2
NDUFA12
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12
chr11_-_107729887 0.23 ENST00000525815.1
SLC35F2
solute carrier family 35, member F2
chr22_-_32767017 0.23 ENST00000400234.1
RFPL3S
RFPL3 antisense
chr2_+_242289502 0.22 ENST00000451310.1
SEPT2
septin 2
chr1_-_243326612 0.22 ENST00000492145.1
ENST00000490813.1
ENST00000464936.1
CEP170
centrosomal protein 170kDa
chr11_-_93583697 0.21 ENST00000409977.1
VSTM5
V-set and transmembrane domain containing 5
chr5_+_162864575 0.20 ENST00000512163.1
ENST00000393929.1
ENST00000340828.2
ENST00000511683.2
ENST00000510097.1
ENST00000511490.2
ENST00000510664.1
CCNG1
cyclin G1
chr3_-_48659193 0.18 ENST00000330862.3
TMEM89
transmembrane protein 89
chr5_+_55147205 0.17 ENST00000396836.2
ENST00000396834.1
ENST00000447346.2
ENST00000359040.5
IL31RA
interleukin 31 receptor A
chr9_+_128509624 0.17 ENST00000342287.5
ENST00000373487.4
PBX3
pre-B-cell leukemia homeobox 3
chr3_-_108248169 0.16 ENST00000273353.3
MYH15
myosin, heavy chain 15
chr20_-_58515344 0.15 ENST00000370996.3
PPP1R3D
protein phosphatase 1, regulatory subunit 3D
chr6_+_151646800 0.13 ENST00000354675.6
AKAP12
A kinase (PRKA) anchor protein 12
chr10_-_43904235 0.11 ENST00000356053.3
HNRNPF
heterogeneous nuclear ribonucleoprotein F
chr15_+_45028719 0.11 ENST00000560442.1
ENST00000558329.1
ENST00000561043.1
TRIM69
tripartite motif containing 69
chr20_+_58203664 0.10 ENST00000541461.1
PHACTR3
phosphatase and actin regulator 3
chr16_+_19421803 0.10 ENST00000541464.1
TMC5
transmembrane channel-like 5
chr10_+_97803151 0.09 ENST00000403870.3
ENST00000265992.5
ENST00000465148.2
ENST00000534974.1
CCNJ
cyclin J
chr13_+_107028897 0.09 ENST00000439790.1
ENST00000435024.1
LINC00460
long intergenic non-protein coding RNA 460
chr6_-_111136513 0.09 ENST00000368911.3
CDK19
cyclin-dependent kinase 19
chr15_+_80351977 0.08 ENST00000559157.1
ENST00000561012.1
ENST00000564367.1
ENST00000558494.1
ZFAND6
zinc finger, AN1-type domain 6
chr1_-_21377383 0.08 ENST00000374935.3
EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr6_+_26183958 0.08 ENST00000356530.3
HIST1H2BE
histone cluster 1, H2be
chr19_+_45116921 0.07 ENST00000402988.1
IGSF23
immunoglobulin superfamily, member 23
chr10_-_94257512 0.07 ENST00000371581.5
IDE
insulin-degrading enzyme
chr15_+_45028753 0.06 ENST00000338264.4
TRIM69
tripartite motif containing 69
chr11_+_2323236 0.05 ENST00000182290.4
TSPAN32
tetraspanin 32
chr17_+_73539339 0.05 ENST00000581713.1
LLGL2
lethal giant larvae homolog 2 (Drosophila)
chr16_+_19422035 0.05 ENST00000381414.4
ENST00000396229.2
TMC5
transmembrane channel-like 5
chr4_+_28437071 0.05 ENST00000509416.1
RP11-123O22.1
RP11-123O22.1
chr13_+_107029084 0.05 ENST00000444865.1
LINC00460
long intergenic non-protein coding RNA 460
chr15_-_44828838 0.05 ENST00000560750.1
EIF3J-AS1
EIF3J antisense RNA 1 (head to head)
chr11_+_71544246 0.05 ENST00000328698.1
DEFB108B
defensin, beta 108B
chr2_+_128403720 0.04 ENST00000272644.3
GPR17
G protein-coupled receptor 17
chr9_-_86955598 0.04 ENST00000376238.4
SLC28A3
solute carrier family 28 (concentrative nucleoside transporter), member 3
chr6_+_42123141 0.04 ENST00000418175.1
ENST00000541991.1
ENST00000053469.4
ENST00000394237.1
ENST00000372963.1
GUCA1A
RP1-139D8.6
guanylate cyclase activator 1A (retina)
RP1-139D8.6
chr2_+_102721023 0.04 ENST00000409589.1
ENST00000409329.1
IL1R1
interleukin 1 receptor, type I
chr7_-_38407770 0.04 ENST00000390348.2
TRGV1
T cell receptor gamma variable 1 (non-functional)
chr1_+_176432298 0.04 ENST00000367661.3
ENST00000367662.3
PAPPA2
pappalysin 2
chr4_-_169401628 0.04 ENST00000514748.1
ENST00000512371.1
ENST00000260184.7
ENST00000505890.1
ENST00000511577.1
DDX60L
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like
chr1_+_225140372 0.04 ENST00000366848.1
ENST00000439375.2
DNAH14
dynein, axonemal, heavy chain 14
chr8_-_146176199 0.03 ENST00000532351.1
ENST00000276816.4
ENST00000394909.2
ZNF16
zinc finger protein 16
chr14_+_24970800 0.03 ENST00000555109.1
RP11-80A15.1
Uncharacterized protein
chr15_+_45028520 0.03 ENST00000329464.4
TRIM69
tripartite motif containing 69
chr1_-_151431647 0.03 ENST00000368863.2
ENST00000409503.1
ENST00000491586.1
ENST00000533351.1
ENST00000540984.1
POGZ
pogo transposable element with ZNF domain
chr6_-_138539627 0.02 ENST00000527246.2
PBOV1
prostate and breast cancer overexpressed 1
chr12_+_54892550 0.02 ENST00000545638.2
NCKAP1L
NCK-associated protein 1-like
chr7_+_157318477 0.02 ENST00000444154.1
AC006372.1
AC006372.1
chr12_-_108955070 0.02 ENST00000228284.3
ENST00000546611.1
SART3
squamous cell carcinoma antigen recognized by T cells 3
chr1_-_151431674 0.02 ENST00000531094.1
POGZ
pogo transposable element with ZNF domain
chr1_-_222014008 0.01 ENST00000431729.1
RP11-191N8.2
RP11-191N8.2
chr16_-_58718611 0.01 ENST00000564100.1
ENST00000570101.1
SLC38A7
solute carrier family 38, member 7
chr12_-_7596735 0.00 ENST00000416109.2
ENST00000396630.1
ENST00000313599.3
CD163L1
CD163 molecule-like 1

Network of associatons between targets according to the STRING database.

First level regulatory network of POU6F1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.5 GO:1903045 neural crest cell migration involved in sympathetic nervous system development(GO:1903045)
0.1 0.3 GO:0009786 regulation of asymmetric cell division(GO:0009786)
0.1 0.4 GO:1902024 histidine transport(GO:0015817) L-histidine transmembrane transport(GO:0089709) L-histidine transport(GO:1902024)
0.1 0.7 GO:0002329 pre-B cell differentiation(GO:0002329)
0.1 0.6 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.1 0.7 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.1 0.2 GO:0007387 anterior compartment pattern formation(GO:0007387) posterior compartment specification(GO:0007388)
0.1 0.7 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.1 0.7 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.0 0.8 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.0 0.6 GO:0042420 dopamine catabolic process(GO:0042420)
0.0 0.6 GO:2000574 regulation of microtubule motor activity(GO:2000574)
0.0 0.5 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.0 0.3 GO:0000055 ribosomal large subunit export from nucleus(GO:0000055)
0.0 1.2 GO:0042730 fibrinolysis(GO:0042730)
0.0 0.5 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.0 0.6 GO:0051531 NFAT protein import into nucleus(GO:0051531)
0.0 0.6 GO:0016180 snRNA processing(GO:0016180)
0.0 0.3 GO:1903003 positive regulation of protein deubiquitination(GO:1903003)
0.0 0.1 GO:1901143 insulin catabolic process(GO:1901143)
0.0 0.4 GO:0071985 multivesicular body sorting pathway(GO:0071985)
0.0 0.3 GO:0060009 Sertoli cell development(GO:0060009)
0.0 0.3 GO:1904714 regulation of chaperone-mediated autophagy(GO:1904714)
0.0 0.1 GO:0030886 negative regulation of myeloid dendritic cell activation(GO:0030886)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0071001 U4/U6 snRNP(GO:0071001)
0.1 0.6 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
0.0 0.3 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.0 0.8 GO:0031209 SCAR complex(GO:0031209)
0.0 0.6 GO:0032039 integrator complex(GO:0032039)
0.0 0.6 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 0.3 GO:0072687 meiotic spindle(GO:0072687)
0.0 0.4 GO:0031088 platelet dense granule membrane(GO:0031088)
0.0 0.3 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.5 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.4 GO:0043220 Schmidt-Lanterman incisure(GO:0043220)
0.0 0.3 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.0 0.5 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 0.2 GO:0097227 sperm annulus(GO:0097227)
0.0 0.2 GO:0042587 glycogen granule(GO:0042587)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0004637 phosphoribosylamine-glycine ligase activity(GO:0004637) phosphoribosylformylglycinamidine cyclo-ligase activity(GO:0004641) phosphoribosylglycinamide formyltransferase activity(GO:0004644)
0.1 0.6 GO:0032184 SUMO polymer binding(GO:0032184)
0.1 1.5 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 0.6 GO:0008131 primary amine oxidase activity(GO:0008131)
0.1 0.4 GO:1901474 azole transmembrane transporter activity(GO:1901474)
0.0 0.6 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.3 GO:0030621 U4 snRNA binding(GO:0030621)
0.0 0.7 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.0 0.1 GO:0031626 beta-endorphin binding(GO:0031626)
0.0 0.7 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.0 0.8 GO:0016805 dipeptidase activity(GO:0016805)
0.0 0.4 GO:0031489 myosin V binding(GO:0031489)
0.0 0.0 GO:0015389 pyrimidine- and adenine-specific:sodium symporter activity(GO:0015389)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 PID IL5 PATHWAY IL5-mediated signaling events
0.0 1.2 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.5 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.3 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 0.7 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 0.6 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.0 0.6 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 1.0 REACTOME MRNA 3 END PROCESSING Genes involved in mRNA 3'-end processing
0.0 0.5 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC