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SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for PPARD

Z-value: 0.80

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Transcription factors associated with PPARD

Gene Symbol Gene ID Gene Info
PPARD
ENSG00000112033.9 peroxisome proliferator activated receptor delta

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PPARDhg19_v2_chr6_+_35310391_35310410-0.912.3e-08Click!

Activity profile of PPARD motif

Sorted Z-values of PPARD motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_+_198365122 3.38 ENST00000604458.1
HSPE1-MOB4
HSPE1-MOB4 readthrough
chr17_+_7123207 3.26 ENST00000584103.1
ENST00000579886.2
ACADVL
acyl-CoA dehydrogenase, very long chain
chr16_+_81272287 3.09 ENST00000425577.2
ENST00000564552.1
BCMO1
beta-carotene 15,15'-monooxygenase 1
chr17_+_9745786 2.69 ENST00000304773.5
GLP2R
glucagon-like peptide 2 receptor
chr11_+_66624527 2.68 ENST00000393952.3
LRFN4
leucine rich repeat and fibronectin type III domain containing 4
chr17_+_4853442 2.47 ENST00000522301.1
ENO3
enolase 3 (beta, muscle)
chr22_-_51017084 2.22 ENST00000360719.2
ENST00000457250.1
ENST00000440709.1
CPT1B
carnitine palmitoyltransferase 1B (muscle)
chrX_+_2746850 2.05 ENST00000381163.3
ENST00000338623.5
ENST00000542787.1
GYG2
glycogenin 2
chr22_-_51016846 2.04 ENST00000312108.7
ENST00000395650.2
CPT1B
carnitine palmitoyltransferase 1B (muscle)
chr16_-_4401258 1.98 ENST00000577031.1
PAM16
presequence translocase-associated motor 16 homolog (S. cerevisiae)
chr16_-_4401284 1.98 ENST00000318059.3
PAM16
presequence translocase-associated motor 16 homolog (S. cerevisiae)
chr12_-_53320245 1.86 ENST00000552150.1
KRT8
keratin 8
chr9_+_126773880 1.77 ENST00000373615.4
LHX2
LIM homeobox 2
chr16_-_74808710 1.77 ENST00000219368.3
ENST00000544337.1
FA2H
fatty acid 2-hydroxylase
chr8_-_80942467 1.72 ENST00000518271.1
ENST00000276585.4
ENST00000521605.1
MRPS28
mitochondrial ribosomal protein S28
chr9_-_33402506 1.66 ENST00000377425.4
ENST00000537089.1
ENST00000297988.1
ENST00000539936.1
ENST00000541274.1
AQP7
aquaporin 7
chr12_+_121163538 1.62 ENST00000242592.4
ACADS
acyl-CoA dehydrogenase, C-2 to C-3 short chain
chr18_-_47340297 1.62 ENST00000586485.1
ENST00000587994.1
ENST00000586100.1
ENST00000285093.10
ACAA2
acetyl-CoA acyltransferase 2
chr7_-_34978980 1.60 ENST00000428054.1
DPY19L1
dpy-19-like 1 (C. elegans)
chr19_-_49339080 1.57 ENST00000595764.1
HSD17B14
hydroxysteroid (17-beta) dehydrogenase 14
chr12_+_121163602 1.44 ENST00000411593.2
ACADS
acyl-CoA dehydrogenase, C-2 to C-3 short chain
chr3_+_48507210 1.41 ENST00000433541.1
ENST00000422277.2
ENST00000436480.2
ENST00000444177.1
TREX1
three prime repair exonuclease 1
chr14_+_32546274 1.34 ENST00000396582.2
ARHGAP5
Rho GTPase activating protein 5
chr2_+_219283815 1.30 ENST00000248444.5
ENST00000454069.1
ENST00000392114.2
VIL1
villin 1
chr20_+_42187682 1.20 ENST00000373092.3
ENST00000373077.1
SGK2
serum/glucocorticoid regulated kinase 2
chr15_+_76030311 1.20 ENST00000543887.1
AC019294.1
AC019294.1
chr1_+_244998602 1.20 ENST00000411948.2
COX20
COX20 cytochrome C oxidase assembly factor
chr19_-_51869592 1.19 ENST00000596253.1
ENST00000309244.4
ETFB
electron-transfer-flavoprotein, beta polypeptide
chr11_+_111169976 1.15 ENST00000398035.2
COLCA2
colorectal cancer associated 2
chr6_+_33172407 1.11 ENST00000374662.3
HSD17B8
hydroxysteroid (17-beta) dehydrogenase 8
chr19_-_10687983 1.07 ENST00000587069.1
AP1M2
adaptor-related protein complex 1, mu 2 subunit
chr2_+_206547215 1.03 ENST00000360409.3
ENST00000540178.1
ENST00000540841.1
ENST00000355117.4
ENST00000450507.1
ENST00000417189.1
NRP2
neuropilin 2
chr19_+_4153598 1.02 ENST00000078445.2
ENST00000252587.3
ENST00000595923.1
ENST00000602257.1
ENST00000602147.1
CREB3L3
cAMP responsive element binding protein 3-like 3
chr8_-_80942061 1.01 ENST00000519386.1
MRPS28
mitochondrial ribosomal protein S28
chr2_-_28113217 1.01 ENST00000444339.2
RBKS
ribokinase
chr7_+_75911902 1.00 ENST00000413003.1
SRRM3
serine/arginine repetitive matrix 3
chr2_+_28113583 0.98 ENST00000344773.2
ENST00000379624.1
ENST00000342045.2
ENST00000379632.2
ENST00000361704.2
BRE
brain and reproductive organ-expressed (TNFRSF1A modulator)
chr2_+_198365095 0.97 ENST00000409468.1
HSPE1
heat shock 10kDa protein 1
chr1_-_153917700 0.95 ENST00000368646.2
DENND4B
DENN/MADD domain containing 4B
chr13_+_113760098 0.94 ENST00000346342.3
ENST00000541084.1
ENST00000375581.3
F7
coagulation factor VII (serum prothrombin conversion accelerator)
chr17_-_7123021 0.94 ENST00000399510.2
DLG4
discs, large homolog 4 (Drosophila)
chr17_+_7123125 0.87 ENST00000356839.5
ENST00000583312.1
ENST00000350303.5
ACADVL
acyl-CoA dehydrogenase, very long chain
chr20_+_42187608 0.86 ENST00000373100.1
SGK2
serum/glucocorticoid regulated kinase 2
chr11_-_45939374 0.83 ENST00000533151.1
ENST00000241041.3
PEX16
peroxisomal biogenesis factor 16
chrX_+_2746818 0.79 ENST00000398806.3
GYG2
glycogenin 2
chr4_+_140586922 0.75 ENST00000265498.1
ENST00000506797.1
MGST2
microsomal glutathione S-transferase 2
chr7_+_7222157 0.74 ENST00000419721.1
C1GALT1
core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1
chr19_-_10687948 0.73 ENST00000592285.1
AP1M2
adaptor-related protein complex 1, mu 2 subunit
chr20_+_46130601 0.72 ENST00000341724.6
NCOA3
nuclear receptor coactivator 3
chr15_+_91449971 0.69 ENST00000557865.1
MAN2A2
mannosidase, alpha, class 2A, member 2
chr11_+_64073699 0.68 ENST00000405666.1
ENST00000468670.1
ESRRA
estrogen-related receptor alpha
chr17_+_73997419 0.67 ENST00000425876.2
CDK3
cyclin-dependent kinase 3
chr12_-_56727487 0.66 ENST00000548043.1
ENST00000425394.2
PAN2
PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)
chr11_-_45939565 0.64 ENST00000525192.1
ENST00000378750.5
PEX16
peroxisomal biogenesis factor 16
chr14_-_51561784 0.64 ENST00000360392.4
TRIM9
tripartite motif containing 9
chr11_+_17281900 0.62 ENST00000530527.1
NUCB2
nucleobindin 2
chr5_-_16509101 0.58 ENST00000399793.2
FAM134B
family with sequence similarity 134, member B
chr11_+_123325106 0.57 ENST00000525757.1
LINC01059
long intergenic non-protein coding RNA 1059
chr19_+_39616410 0.56 ENST00000602004.1
ENST00000599470.1
ENST00000321944.4
ENST00000593480.1
ENST00000358301.3
ENST00000593690.1
ENST00000599386.1
PAK4
p21 protein (Cdc42/Rac)-activated kinase 4
chrX_-_148571884 0.56 ENST00000537071.1
IDS
iduronate 2-sulfatase
chr1_-_161039456 0.55 ENST00000368016.3
ARHGAP30
Rho GTPase activating protein 30
chr8_-_80942139 0.55 ENST00000521434.1
ENST00000519120.1
ENST00000520946.1
MRPS28
mitochondrial ribosomal protein S28
chr17_-_71223839 0.54 ENST00000579872.1
ENST00000580032.1
FAM104A
family with sequence similarity 104, member A
chr17_+_7483761 0.54 ENST00000584180.1
CD68
CD68 molecule
chr15_+_75494214 0.53 ENST00000394987.4
C15orf39
chromosome 15 open reading frame 39
chr3_-_53878644 0.53 ENST00000481668.1
ENST00000467802.1
CHDH
choline dehydrogenase
chr12_-_56727676 0.51 ENST00000547572.1
ENST00000257931.5
ENST00000440411.3
PAN2
PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)
chr3_-_50605077 0.49 ENST00000426034.1
ENST00000441239.1
C3orf18
chromosome 3 open reading frame 18
chr9_+_131037623 0.48 ENST00000495313.1
ENST00000372898.2
SWI5
SWI5 recombination repair homolog (yeast)
chr11_+_111169565 0.47 ENST00000528846.1
COLCA2
colorectal cancer associated 2
chr16_-_28303360 0.46 ENST00000501520.1
RP11-57A19.2
RP11-57A19.2
chr2_+_73441350 0.46 ENST00000389501.4
SMYD5
SMYD family member 5
chr22_-_42526802 0.45 ENST00000359033.4
ENST00000389970.3
ENST00000360608.5
CYP2D6
cytochrome P450, family 2, subfamily D, polypeptide 6
chr20_-_44485835 0.44 ENST00000457981.1
ENST00000426915.1
ENST00000217455.4
ACOT8
acyl-CoA thioesterase 8
chr12_-_109797249 0.44 ENST00000538041.1
RP11-256L11.1
RP11-256L11.1
chr7_-_87342564 0.43 ENST00000265724.3
ENST00000416177.1
ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
chr12_+_131438443 0.40 ENST00000261654.5
GPR133
G protein-coupled receptor 133
chr5_-_176981417 0.39 ENST00000514747.1
ENST00000443375.2
ENST00000329540.5
FAM193B
family with sequence similarity 193, member B
chr7_+_112090483 0.38 ENST00000403825.3
ENST00000429071.1
IFRD1
interferon-related developmental regulator 1
chr22_+_30163340 0.37 ENST00000330029.6
ENST00000401406.3
UQCR10
ubiquinol-cytochrome c reductase, complex III subunit X
chr16_+_2255841 0.36 ENST00000301725.7
MLST8
MTOR associated protein, LST8 homolog (S. cerevisiae)
chr2_+_228190066 0.36 ENST00000436237.1
ENST00000443428.2
ENST00000418961.1
MFF
mitochondrial fission factor
chr1_+_165864800 0.36 ENST00000469256.2
UCK2
uridine-cytidine kinase 2
chr15_+_82555125 0.35 ENST00000566205.1
ENST00000339465.5
ENST00000569120.1
ENST00000566861.1
FAM154B
family with sequence similarity 154, member B
chr3_+_19189946 0.33 ENST00000328405.2
KCNH8
potassium voltage-gated channel, subfamily H (eag-related), member 8
chr16_+_2255710 0.33 ENST00000397124.1
ENST00000565250.1
MLST8
MTOR associated protein, LST8 homolog (S. cerevisiae)
chr1_-_43855479 0.33 ENST00000290663.6
ENST00000372457.4
MED8
mediator complex subunit 8
chr12_-_21757774 0.29 ENST00000261195.2
GYS2
glycogen synthase 2 (liver)
chr3_-_48936272 0.28 ENST00000544097.1
ENST00000430379.1
ENST00000319017.4
SLC25A20
solute carrier family 25 (carnitine/acylcarnitine translocase), member 20
chr1_-_160832490 0.28 ENST00000322302.7
ENST00000368033.3
CD244
CD244 molecule, natural killer cell receptor 2B4
chr9_+_131901661 0.27 ENST00000423100.1
PPP2R4
protein phosphatase 2A activator, regulatory subunit 4
chr1_+_165864821 0.26 ENST00000470820.1
UCK2
uridine-cytidine kinase 2
chr1_+_159175201 0.26 ENST00000368121.2
DARC
Duffy blood group, atypical chemokine receptor
chr6_+_72922590 0.25 ENST00000523963.1
RIMS1
regulating synaptic membrane exocytosis 1
chr2_-_99871570 0.23 ENST00000333017.2
ENST00000409679.1
ENST00000423306.1
LYG2
lysozyme G-like 2
chr6_+_72922505 0.23 ENST00000401910.3
RIMS1
regulating synaptic membrane exocytosis 1
chr11_-_47470682 0.23 ENST00000529341.1
ENST00000352508.3
RAPSN
receptor-associated protein of the synapse
chr1_+_202317855 0.22 ENST00000356764.2
PPP1R12B
protein phosphatase 1, regulatory subunit 12B
chr1_-_43855444 0.22 ENST00000372455.4
MED8
mediator complex subunit 8
chr2_+_178257372 0.21 ENST00000264167.4
ENST00000409888.1
AGPS
alkylglycerone phosphate synthase
chr1_-_109968973 0.20 ENST00000271308.4
ENST00000538610.1
PSMA5
proteasome (prosome, macropain) subunit, alpha type, 5
chr19_+_49867181 0.19 ENST00000597546.1
DKKL1
dickkopf-like 1
chr1_-_161039647 0.18 ENST00000368013.3
ARHGAP30
Rho GTPase activating protein 30
chr17_+_37894179 0.18 ENST00000577695.1
ENST00000309156.4
ENST00000309185.3
GRB7
growth factor receptor-bound protein 7
chr3_-_187009646 0.15 ENST00000296280.6
ENST00000392470.2
ENST00000169293.6
ENST00000439271.1
ENST00000392472.2
ENST00000392475.2
MASP1
mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)
chr1_-_160832642 0.13 ENST00000368034.4
CD244
CD244 molecule, natural killer cell receptor 2B4
chr16_-_75285380 0.13 ENST00000393420.6
ENST00000162330.5
BCAR1
breast cancer anti-estrogen resistance 1
chr1_-_120311517 0.13 ENST00000369406.3
ENST00000544913.2
HMGCS2
3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
chr19_+_29493486 0.12 ENST00000589821.1
CTD-2081K17.2
CTD-2081K17.2
chr9_+_34458771 0.12 ENST00000437363.1
ENST00000242317.4
DNAI1
dynein, axonemal, intermediate chain 1
chr3_-_187009798 0.12 ENST00000337774.5
MASP1
mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)
chr7_+_7222233 0.11 ENST00000436587.2
C1GALT1
core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1
chr6_+_31637944 0.11 ENST00000375864.4
LY6G5B
lymphocyte antigen 6 complex, locus G5B
chr10_-_49459800 0.11 ENST00000305531.3
FRMPD2
FERM and PDZ domain containing 2
chr10_-_74714533 0.10 ENST00000373032.3
PLA2G12B
phospholipase A2, group XIIB
chr4_-_108204846 0.10 ENST00000513208.1
DKK2
dickkopf WNT signaling pathway inhibitor 2
chr10_-_94050820 0.10 ENST00000265997.4
CPEB3
cytoplasmic polyadenylation element binding protein 3
chr1_-_161193349 0.09 ENST00000469730.2
ENST00000463273.1
ENST00000464492.1
ENST00000367990.3
ENST00000470459.2
ENST00000468465.1
ENST00000463812.1
APOA2
apolipoprotein A-II
chr19_+_29493456 0.09 ENST00000591143.1
ENST00000592653.1
CTD-2081K17.2
CTD-2081K17.2
chr9_+_35042205 0.08 ENST00000312292.5
ENST00000378745.3
C9orf131
chromosome 9 open reading frame 131
chr2_+_115919684 0.08 ENST00000310323.8
DPP10
dipeptidyl-peptidase 10 (non-functional)
chr2_+_39117010 0.08 ENST00000409978.1
ARHGEF33
Rho guanine nucleotide exchange factor (GEF) 33
chr2_+_120125245 0.07 ENST00000393103.2
DBI
diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
chr12_-_16762802 0.07 ENST00000534946.1
LMO3
LIM domain only 3 (rhombotin-like 2)
chr15_+_78441663 0.07 ENST00000299518.2
ENST00000558554.1
ENST00000557826.1
ENST00000561279.1
ENST00000559186.1
ENST00000560770.1
ENST00000559881.1
ENST00000559205.1
ENST00000441490.2
IDH3A
isocitrate dehydrogenase 3 (NAD+) alpha
chrX_-_108868390 0.06 ENST00000372101.2
KCNE1L
KCNE1-like
chr6_+_88299833 0.06 ENST00000392844.3
ENST00000257789.4
ENST00000546266.1
ENST00000417380.2
ORC3
origin recognition complex, subunit 3
chr3_-_49203744 0.06 ENST00000321895.6
CCDC71
coiled-coil domain containing 71
chr2_+_219433281 0.05 ENST00000273064.6
ENST00000509807.2
ENST00000542068.1
RQCD1
RCD1 required for cell differentiation1 homolog (S. pombe)
chr1_+_145727681 0.05 ENST00000417171.1
ENST00000451928.2
PDZK1
PDZ domain containing 1
chr11_+_7595136 0.04 ENST00000529575.1
PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr1_-_161102421 0.04 ENST00000490843.2
ENST00000368006.3
ENST00000392188.1
ENST00000545495.1
DEDD
death effector domain containing
chr2_-_198364552 0.02 ENST00000439605.1
ENST00000418022.1
HSPD1
heat shock 60kDa protein 1 (chaperonin)
chr1_-_11863171 0.01 ENST00000376592.1
MTHFR
methylenetetrahydrofolate reductase (NAD(P)H)
chr11_-_47470591 0.01 ENST00000524487.1
RAPSN
receptor-associated protein of the synapse
chr17_-_34270697 0.01 ENST00000585556.1
LYZL6
lysozyme-like 6
chr1_-_161039753 0.00 ENST00000368015.1
ARHGAP30
Rho GTPase activating protein 30

Network of associatons between targets according to the STRING database.

First level regulatory network of PPARD

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.5 GO:0032581 ER-dependent peroxisome organization(GO:0032581)
0.3 1.6 GO:1902109 negative regulation of mitochondrial membrane permeability involved in apoptotic process(GO:1902109)
0.3 4.1 GO:0046322 negative regulation of fatty acid oxidation(GO:0046322)
0.2 0.9 GO:1905225 response to thyrotropin-releasing hormone(GO:1905225)
0.2 4.5 GO:0006853 carnitine shuttle(GO:0006853)
0.2 0.9 GO:0016267 O-glycan processing, core 1(GO:0016267)
0.2 1.0 GO:0019303 D-ribose catabolic process(GO:0019303)
0.2 1.3 GO:1902896 terminal web assembly(GO:1902896)
0.2 1.7 GO:0015793 glycerol transport(GO:0015793)
0.2 4.0 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.2 0.6 GO:0035544 negative regulation of SNARE complex assembly(GO:0035544)
0.2 0.6 GO:0009224 CMP salvage(GO:0006238) CMP biosynthetic process(GO:0009224) CMP metabolic process(GO:0046035)
0.1 1.8 GO:0032286 central nervous system myelin maintenance(GO:0032286)
0.1 1.6 GO:0018406 protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.1 0.4 GO:0071661 granzyme B production(GO:0071613) regulation of granzyme B production(GO:0071661) positive regulation of granzyme B production(GO:0071663)
0.1 0.5 GO:0019285 glycine betaine biosynthetic process from choline(GO:0019285) glycine betaine metabolic process(GO:0031455) glycine betaine biosynthetic process(GO:0031456)
0.1 2.7 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.1 1.0 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.1 0.4 GO:0033076 alkaloid catabolic process(GO:0009822) isoquinoline alkaloid metabolic process(GO:0033076) cellular organohalogen metabolic process(GO:0090345) cellular organofluorine metabolic process(GO:0090346)
0.1 1.9 GO:0051599 response to hydrostatic pressure(GO:0051599)
0.1 0.7 GO:0035624 receptor transactivation(GO:0035624)
0.1 1.8 GO:0021978 telencephalon regionalization(GO:0021978)
0.1 0.2 GO:1900073 regulation of neuromuscular synaptic transmission(GO:1900073) positive regulation of neuromuscular synaptic transmission(GO:1900075)
0.1 1.0 GO:0097491 sympathetic neuron projection extension(GO:0097490) sympathetic neuron projection guidance(GO:0097491)
0.1 1.0 GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440)
0.1 0.7 GO:0006013 mannose metabolic process(GO:0006013)
0.1 0.9 GO:2000821 regulation of grooming behavior(GO:2000821)
0.1 0.4 GO:1900063 regulation of peroxisome organization(GO:1900063)
0.1 2.8 GO:0005980 glycogen catabolic process(GO:0005980)
0.1 1.2 GO:0033617 mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.1 0.4 GO:1901529 positive regulation of anion channel activity(GO:1901529)
0.0 0.4 GO:0048625 myoblast fate commitment(GO:0048625)
0.0 0.4 GO:0034551 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.0 2.5 GO:0061718 NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.0 0.2 GO:0008611 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.0 2.7 GO:0071377 cellular response to glucagon stimulus(GO:0071377)
0.0 0.7 GO:0045023 G0 to G1 transition(GO:0045023)
0.0 0.3 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.0 0.1 GO:1900365 positive regulation of mRNA polyadenylation(GO:1900365)
0.0 0.1 GO:2000910 negative regulation of cholesterol import(GO:0060621) negative regulation of sterol import(GO:2000910)
0.0 0.2 GO:0000270 peptidoglycan metabolic process(GO:0000270) peptidoglycan catabolic process(GO:0009253)
0.0 0.5 GO:0000730 DNA recombinase assembly(GO:0000730) double-strand break repair via synthesis-dependent strand annealing(GO:0045003)
0.0 3.3 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.0 1.4 GO:0006298 mismatch repair(GO:0006298)
0.0 0.5 GO:0098828 positive regulation of inhibitory postsynaptic potential(GO:0097151) modulation of inhibitory postsynaptic potential(GO:0098828)
0.0 0.1 GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.0 0.7 GO:1901685 glutathione derivative metabolic process(GO:1901685) glutathione derivative biosynthetic process(GO:1901687)
0.0 0.5 GO:0051085 chaperone mediated protein folding requiring cofactor(GO:0051085)
0.0 1.2 GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic(GO:0090503)
0.0 0.4 GO:0010561 negative regulation of glycoprotein biosynthetic process(GO:0010561)
0.0 0.6 GO:0030207 chondroitin sulfate catabolic process(GO:0030207)
0.0 2.1 GO:0032411 positive regulation of transporter activity(GO:0032411)
0.0 0.7 GO:0032008 positive regulation of TOR signaling(GO:0032008)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 3.4 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.3 1.2 GO:0031251 PAN complex(GO:0031251)
0.3 2.5 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.1 0.5 GO:0032798 Swi5-Sfr1 complex(GO:0032798)
0.1 3.3 GO:0005763 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.1 1.0 GO:0002116 semaphorin receptor complex(GO:0002116)
0.1 1.2 GO:0099634 postsynaptic specialization membrane(GO:0099634)
0.1 4.1 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1 1.3 GO:0032433 filopodium tip(GO:0032433)
0.0 1.9 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.7 GO:0031931 TORC1 complex(GO:0031931)
0.0 1.5 GO:0005779 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.0 0.4 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.0 0.1 GO:0036387 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
0.0 3.4 GO:0043202 lysosomal lumen(GO:0043202)
0.0 0.2 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.0 1.6 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 0.7 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 0.5 GO:0016592 mediator complex(GO:0016592)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.7 GO:0004967 glucagon receptor activity(GO:0004967)
0.6 2.8 GO:0008466 glycogenin glucosyltransferase activity(GO:0008466)
0.5 4.3 GO:0004095 carnitine O-palmitoyltransferase activity(GO:0004095)
0.5 4.1 GO:0004466 long-chain-acyl-CoA dehydrogenase activity(GO:0004466)
0.4 1.1 GO:0047025 3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity(GO:0047025)
0.3 1.7 GO:0015254 glycerol channel activity(GO:0015254)
0.3 2.5 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.2 0.7 GO:0004464 leukotriene-C4 synthase activity(GO:0004464)
0.2 1.4 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.2 0.9 GO:0031811 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.2 1.6 GO:0047045 testosterone 17-beta-dehydrogenase (NADP+) activity(GO:0047045)
0.2 0.9 GO:0016263 glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity(GO:0016263)
0.2 0.6 GO:0004423 iduronate-2-sulfatase activity(GO:0004423)
0.2 3.1 GO:0003995 acyl-CoA dehydrogenase activity(GO:0003995)
0.2 1.6 GO:0003988 acetyl-CoA C-acyltransferase activity(GO:0003988)
0.1 0.7 GO:0004572 mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity(GO:0004572)
0.1 1.3 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.1 0.4 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)
0.1 0.4 GO:0090554 phosphatidylcholine-translocating ATPase activity(GO:0090554)
0.1 0.3 GO:0015227 acyl carnitine transmembrane transporter activity(GO:0015227)
0.1 2.1 GO:0017081 chloride channel regulator activity(GO:0017081)
0.1 1.0 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.1 0.6 GO:0004849 uridine kinase activity(GO:0004849)
0.0 0.4 GO:0016681 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0 1.6 GO:0000030 mannosyltransferase activity(GO:0000030)
0.0 1.2 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 0.1 GO:0004421 hydroxymethylglutaryl-CoA synthase activity(GO:0004421)
0.0 0.3 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.0 0.3 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.0 1.0 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.1 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
0.0 1.0 GO:0019200 carbohydrate kinase activity(GO:0019200)
0.0 0.2 GO:0003796 lysozyme activity(GO:0003796)
0.0 0.1 GO:0004449 isocitrate dehydrogenase (NAD+) activity(GO:0004449)
0.0 0.7 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 1.9 GO:0097110 scaffold protein binding(GO:0097110)
0.0 0.4 GO:0070330 aromatase activity(GO:0070330)
0.0 0.7 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 0.6 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.0 0.4 GO:0042288 MHC class I protein binding(GO:0042288)
0.0 0.8 GO:0042169 SH2 domain binding(GO:0042169)
0.0 0.7 GO:0030332 cyclin binding(GO:0030332)
0.0 0.2 GO:0033130 acetylcholine receptor binding(GO:0033130)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 8.4 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 1.0 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.0 0.7 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.0 1.9 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 0.9 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 7.2 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.1 1.7 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.1 4.5 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.1 2.8 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.1 0.9 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.0 2.7 REACTOME GLUCAGON TYPE LIGAND RECEPTORS Genes involved in Glucagon-type ligand receptors
0.0 1.0 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 2.4 REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D Genes involved in Metabolism of steroid hormones and vitamins A and D
0.0 2.5 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.0 2.9 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.7 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.0 0.4 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.0 0.4 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.0 0.5 REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.0 0.6 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 0.6 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.0 0.7 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.4 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.0 0.7 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 0.6 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism