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SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for PRDM14

Z-value: 0.90

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Transcription factors associated with PRDM14

Gene Symbol Gene ID Gene Info
PRDM14
ENSG00000147596.3 PR/SET domain 14

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PRDM14hg19_v2_chr8_-_70983506_70983562-0.435.5e-02Click!

Activity profile of PRDM14 motif

Sorted Z-values of PRDM14 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr17_-_19651654 4.51 ENST00000395555.3
ALDH3A1
aldehyde dehydrogenase 3 family, member A1
chr17_-_19651598 4.35 ENST00000570414.1
ALDH3A1
aldehyde dehydrogenase 3 family, member A1
chr17_-_19651668 4.12 ENST00000494157.2
ENST00000225740.6
ALDH3A1
aldehyde dehydrogenase 3 family, member A1
chr2_-_228244013 3.77 ENST00000304568.3
TM4SF20
transmembrane 4 L six family member 20
chr17_-_46692287 3.76 ENST00000239144.4
HOXB8
homeobox B8
chr17_-_46691990 3.05 ENST00000576562.1
HOXB8
homeobox B8
chr17_-_17485731 2.14 ENST00000395783.1
PEMT
phosphatidylethanolamine N-methyltransferase
chr1_+_155006300 1.75 ENST00000295542.1
ENST00000392480.1
ENST00000423025.2
ENST00000368419.2
DCST1
DC-STAMP domain containing 1
chr12_+_121647868 1.58 ENST00000359949.7
ENST00000541532.1
ENST00000543171.1
ENST00000538701.1
P2RX4
purinergic receptor P2X, ligand-gated ion channel, 4
chr3_-_155394099 1.52 ENST00000414191.1
PLCH1
phospholipase C, eta 1
chr1_+_156052354 1.51 ENST00000368301.2
LMNA
lamin A/C
chr3_-_155394152 1.34 ENST00000494598.1
PLCH1
phospholipase C, eta 1
chr17_+_36873677 1.32 ENST00000471200.1
MLLT6
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6
chr3_-_134092561 1.32 ENST00000510560.1
ENST00000504234.1
ENST00000515172.1
AMOTL2
angiomotin like 2
chr2_+_101437487 1.25 ENST00000427413.1
ENST00000542504.1
NPAS2
neuronal PAS domain protein 2
chr4_-_103266626 1.25 ENST00000356736.4
SLC39A8
solute carrier family 39 (zinc transporter), member 8
chr4_+_4861385 1.23 ENST00000382723.4
MSX1
msh homeobox 1
chr5_+_32710736 1.16 ENST00000415685.2
NPR3
natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)
chr5_-_108063949 1.16 ENST00000606054.1
LINC01023
long intergenic non-protein coding RNA 1023
chr12_+_121647962 1.15 ENST00000542067.1
P2RX4
purinergic receptor P2X, ligand-gated ion channel, 4
chr1_+_153963227 1.15 ENST00000368567.4
ENST00000392558.4
RPS27
ribosomal protein S27
chr1_-_155006224 1.06 ENST00000368424.3
DCST2
DC-STAMP domain containing 2
chr5_+_32711419 1.06 ENST00000265074.8
NPR3
natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)
chr1_+_109102652 1.04 ENST00000370035.3
ENST00000405454.1
FAM102B
family with sequence similarity 102, member B
chr3_+_37035289 1.02 ENST00000455445.2
ENST00000441265.1
ENST00000435176.1
ENST00000429117.1
ENST00000536378.1
MLH1
mutL homolog 1
chr12_-_124456598 1.01 ENST00000539761.1
ENST00000539551.1
CCDC92
coiled-coil domain containing 92
chr11_+_85956182 0.97 ENST00000327320.4
ENST00000351625.6
ENST00000534595.1
EED
embryonic ectoderm development
chr3_+_37035263 0.96 ENST00000458205.2
ENST00000539477.1
MLH1
mutL homolog 1
chr19_+_49838653 0.93 ENST00000598095.1
ENST00000426897.2
ENST00000323906.4
ENST00000535669.2
ENST00000597602.1
ENST00000595660.1
CD37
CD37 molecule
chr8_+_110346546 0.93 ENST00000521662.1
ENST00000521688.1
ENST00000520147.1
ENY2
enhancer of yellow 2 homolog (Drosophila)
chr1_-_155006254 0.86 ENST00000295536.5
DCST2
DC-STAMP domain containing 2
chr2_-_192711968 0.83 ENST00000304141.4
SDPR
serum deprivation response
chr17_-_73775839 0.83 ENST00000592643.1
ENST00000591890.1
ENST00000587171.1
ENST00000254810.4
ENST00000589599.1
H3F3B
H3 histone, family 3B (H3.3B)
chr19_-_49314269 0.75 ENST00000545387.2
ENST00000316273.6
ENST00000402551.1
ENST00000598162.1
ENST00000599246.1
BCAT2
branched chain amino-acid transaminase 2, mitochondrial
chr8_+_101349823 0.73 ENST00000519566.1
KB-1991G8.1
KB-1991G8.1
chr16_-_55866997 0.68 ENST00000360526.3
ENST00000361503.4
CES1
carboxylesterase 1
chr19_+_39109735 0.64 ENST00000593149.1
ENST00000248342.4
ENST00000538434.1
ENST00000588934.1
ENST00000545173.2
ENST00000589307.1
ENST00000586513.1
ENST00000591409.1
ENST00000592558.1
EIF3K
eukaryotic translation initiation factor 3, subunit K
chr11_-_62474803 0.63 ENST00000533982.1
ENST00000360796.5
BSCL2
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr14_-_54425475 0.62 ENST00000559642.1
BMP4
bone morphogenetic protein 4
chr19_+_38880252 0.60 ENST00000586301.1
SPRED3
sprouty-related, EVH1 domain containing 3
chr2_-_145278475 0.59 ENST00000558170.2
ZEB2
zinc finger E-box binding homeobox 2
chr17_-_2117600 0.56 ENST00000572369.1
SMG6
SMG6 nonsense mediated mRNA decay factor
chr14_+_89290965 0.55 ENST00000345383.5
ENST00000536576.1
ENST00000346301.4
ENST00000338104.6
ENST00000354441.6
ENST00000380656.2
ENST00000556651.1
ENST00000554686.1
TTC8
tetratricopeptide repeat domain 8
chr17_-_46692457 0.54 ENST00000468443.1
HOXB8
homeobox B8
chr3_+_16926441 0.54 ENST00000418129.2
ENST00000396755.2
PLCL2
phospholipase C-like 2
chr15_-_45694380 0.52 ENST00000561148.1
GATM
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr3_-_114477962 0.49 ENST00000471418.1
ZBTB20
zinc finger and BTB domain containing 20
chr11_+_64879317 0.41 ENST00000526809.1
ENST00000279263.7
ENST00000524986.1
ENST00000534371.1
ENST00000540748.1
ENST00000525385.1
ENST00000345348.5
ENST00000531321.1
ENST00000529414.1
ENST00000526085.1
ENST00000530750.1
TM7SF2
transmembrane 7 superfamily member 2
chr13_-_34250861 0.40 ENST00000445227.1
ENST00000454681.2
RP11-141M1.3
RP11-141M1.3
chr1_+_27114418 0.37 ENST00000078527.4
PIGV
phosphatidylinositol glycan anchor biosynthesis, class V
chr15_+_63188009 0.36 ENST00000557900.1
RP11-1069G10.2
RP11-1069G10.2
chr19_-_49314169 0.35 ENST00000597011.1
ENST00000601681.1
BCAT2
branched chain amino-acid transaminase 2, mitochondrial
chr15_+_69850521 0.31 ENST00000558781.1
RP11-279F6.1
RP11-279F6.1
chr12_-_76742183 0.30 ENST00000393262.3
BBS10
Bardet-Biedl syndrome 10
chr5_-_55777586 0.29 ENST00000506836.1
CTC-236F12.4
Uncharacterized protein
chr1_+_27114589 0.29 ENST00000431541.1
ENST00000449950.2
ENST00000374145.1
PIGV
phosphatidylinositol glycan anchor biosynthesis, class V
chr18_+_57567180 0.29 ENST00000316660.6
ENST00000269518.9
PMAIP1
phorbol-12-myristate-13-acetate-induced protein 1
chr6_+_72926145 0.28 ENST00000425662.2
ENST00000453976.2
RIMS1
regulating synaptic membrane exocytosis 1
chr3_+_10289707 0.27 ENST00000287652.4
TATDN2
TatD DNase domain containing 2
chr6_+_133561725 0.27 ENST00000452339.2
EYA4
eyes absent homolog 4 (Drosophila)
chr2_-_145277882 0.24 ENST00000465070.1
ENST00000444559.1
ZEB2
zinc finger E-box binding homeobox 2
chr7_-_124405681 0.24 ENST00000303921.2
GPR37
G protein-coupled receptor 37 (endothelin receptor type B-like)
chr8_-_102216925 0.22 ENST00000517844.1
ZNF706
zinc finger protein 706
chr11_-_46615498 0.19 ENST00000533727.1
ENST00000534300.1
ENST00000528950.1
ENST00000526606.1
AMBRA1
autophagy/beclin-1 regulator 1
chr7_-_140714739 0.18 ENST00000467334.1
ENST00000324787.5
MRPS33
mitochondrial ribosomal protein S33
chr15_+_45694567 0.17 ENST00000559860.1
SPATA5L1
spermatogenesis associated 5-like 1
chr7_-_140714430 0.16 ENST00000393008.3
MRPS33
mitochondrial ribosomal protein S33
chr6_-_46048116 0.15 ENST00000185206.6
CLIC5
chloride intracellular channel 5
chr4_+_141677577 0.14 ENST00000609937.1
RP11-102N12.3
RP11-102N12.3
chr19_+_3572758 0.14 ENST00000416526.1
HMG20B
high mobility group 20B
chr1_+_45274154 0.13 ENST00000450269.1
ENST00000453418.1
ENST00000409335.2
BTBD19
BTB (POZ) domain containing 19
chr12_+_49760639 0.11 ENST00000549538.1
ENST00000548654.1
ENST00000550643.1
ENST00000548710.1
ENST00000549179.1
ENST00000548377.1
SPATS2
spermatogenesis associated, serine-rich 2
chr7_-_139763521 0.11 ENST00000263549.3
PARP12
poly (ADP-ribose) polymerase family, member 12
chr15_+_45694523 0.10 ENST00000305560.6
SPATA5L1
spermatogenesis associated 5-like 1
chr11_-_62439727 0.09 ENST00000528862.1
C11orf48
chromosome 11 open reading frame 48
chr10_+_12171721 0.07 ENST00000379020.4
ENST00000379017.3
SEC61A2
Sec61 alpha 2 subunit (S. cerevisiae)
chr17_+_39994032 0.06 ENST00000293303.4
ENST00000438813.1
KLHL10
kelch-like family member 10
chr1_+_65730385 0.05 ENST00000263441.7
ENST00000395325.3
DNAJC6
DnaJ (Hsp40) homolog, subfamily C, member 6
chrX_+_15525426 0.05 ENST00000342014.6
BMX
BMX non-receptor tyrosine kinase
chr1_-_42384343 0.05 ENST00000372584.1
HIVEP3
human immunodeficiency virus type I enhancer binding protein 3
chr3_-_47517302 0.00 ENST00000441517.2
ENST00000545718.1
SCAP
SREBF chaperone
chr3_+_155838337 0.00 ENST00000490337.1
ENST00000389636.5
KCNAB1
potassium voltage-gated channel, shaker-related subfamily, beta member 1

Network of associatons between targets according to the STRING database.

First level regulatory network of PRDM14

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.0 GO:0051311 meiotic metaphase I plate congression(GO:0043060) meiotic spindle midzone assembly(GO:0051257) meiotic metaphase plate congression(GO:0051311)
0.4 1.2 GO:0090427 activation of meiosis(GO:0090427)
0.3 1.5 GO:0035105 sterol regulatory element binding protein import into nucleus(GO:0035105)
0.3 1.1 GO:0006550 isoleucine catabolic process(GO:0006550)
0.2 7.4 GO:0021516 dorsal spinal cord development(GO:0021516)
0.2 2.1 GO:0050747 positive regulation of lipoprotein metabolic process(GO:0050747)
0.2 2.7 GO:0032306 regulation of prostaglandin secretion(GO:0032306) positive regulation of prostaglandin secretion(GO:0032308)
0.2 0.5 GO:0002337 B-1a B cell differentiation(GO:0002337)
0.2 0.7 GO:0090119 vesicle-mediated cholesterol transport(GO:0090119)
0.1 2.2 GO:0002158 osteoclast proliferation(GO:0002158)
0.1 0.5 GO:0006601 creatine biosynthetic process(GO:0006601)
0.1 0.6 GO:0055018 apoptotic process involved in endocardial cushion morphogenesis(GO:0003277) tendon cell differentiation(GO:0035990) tendon formation(GO:0035992) intermediate mesoderm morphogenesis(GO:0048390) intermediate mesoderm formation(GO:0048391) intermediate mesodermal cell differentiation(GO:0048392) regulation of cardiac muscle fiber development(GO:0055018) positive regulation of cardiac muscle fiber development(GO:0055020) bud dilation involved in lung branching(GO:0060503) BMP signaling pathway involved in ureter morphogenesis(GO:0061149) renal system segmentation(GO:0061150) BMP signaling pathway involved in renal system segmentation(GO:0061151) pulmonary artery endothelial tube morphogenesis(GO:0061155) regulation of transcription from RNA polymerase II promoter involved in mesonephros development(GO:0061216) BMP signaling pathway involved in nephric duct formation(GO:0071893) negative regulation of branch elongation involved in ureteric bud branching(GO:0072096) negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway(GO:0072097) anterior/posterior pattern specification involved in ureteric bud development(GO:0072099) specification of ureteric bud anterior/posterior symmetry(GO:0072100) specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway(GO:0072101) ureter epithelial cell differentiation(GO:0072192) negative regulation of mesenchymal cell proliferation involved in ureter development(GO:0072200) positive regulation of cell proliferation involved in outflow tract morphogenesis(GO:1901964) cardiac jelly development(GO:1905072) regulation of metanephric S-shaped body morphogenesis(GO:2000004) negative regulation of metanephric S-shaped body morphogenesis(GO:2000005) regulation of metanephric comma-shaped body morphogenesis(GO:2000006) negative regulation of metanephric comma-shaped body morphogenesis(GO:2000007)
0.1 1.2 GO:0015691 cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.1 13.0 GO:0006081 cellular aldehyde metabolic process(GO:0006081)
0.1 0.8 GO:1902748 positive regulation of lens fiber cell differentiation(GO:1902748)
0.1 1.0 GO:0061087 positive regulation of histone H3-K27 methylation(GO:0061087)
0.1 0.6 GO:0050893 sensory processing(GO:0050893)
0.1 0.9 GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
0.1 1.3 GO:0051775 response to redox state(GO:0051775)
0.0 1.1 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.0 0.6 GO:1904354 negative regulation of telomere capping(GO:1904354)
0.0 0.2 GO:0045964 positive regulation of catecholamine metabolic process(GO:0045915) positive regulation of dopamine metabolic process(GO:0045964)
0.0 0.7 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
0.0 2.9 GO:0043647 inositol phosphate metabolic process(GO:0043647)
0.0 0.3 GO:0010917 negative regulation of mitochondrial membrane potential(GO:0010917)
0.0 0.6 GO:0034389 lipid particle organization(GO:0034389)
0.0 1.3 GO:0035329 hippo signaling(GO:0035329)
0.0 0.2 GO:1902455 negative regulation of stem cell population maintenance(GO:1902455)
0.0 0.3 GO:0097151 positive regulation of inhibitory postsynaptic potential(GO:0097151) modulation of inhibitory postsynaptic potential(GO:0098828)
0.0 0.1 GO:0090598 male genitalia morphogenesis(GO:0048808) male anatomical structure morphogenesis(GO:0090598)
0.0 0.3 GO:0016576 histone dephosphorylation(GO:0016576)
0.0 0.9 GO:0007166 cell surface receptor signaling pathway(GO:0007166)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.0 GO:0005715 late recombination nodule(GO:0005715)
0.2 1.5 GO:0005638 lamin filament(GO:0005638)
0.1 0.6 GO:0000333 telomerase catalytic core complex(GO:0000333)
0.1 0.7 GO:0031501 mannosyltransferase complex(GO:0031501)
0.1 1.0 GO:0001739 sex chromatin(GO:0001739)
0.1 2.7 GO:0005639 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0 0.9 GO:0000124 SAGA complex(GO:0000124)
0.0 0.6 GO:0034464 BBSome(GO:0034464)
0.0 0.5 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 1.7 GO:0031526 brush border membrane(GO:0031526)
0.0 1.1 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 0.9 GO:0001772 immunological synapse(GO:0001772)
0.0 0.3 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 13.0 GO:0018479 benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
1.0 2.9 GO:0050429 calcium-dependent phospholipase C activity(GO:0050429)
0.7 2.1 GO:0004608 phosphatidyl-N-methylethanolamine N-methyltransferase activity(GO:0000773) phosphatidylethanolamine N-methyltransferase activity(GO:0004608) phosphatidyl-N-dimethylethanolamine N-methyltransferase activity(GO:0080101)
0.3 2.2 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.2 2.7 GO:0004931 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.2 0.7 GO:0004584 dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity(GO:0004584)
0.2 2.0 GO:0032137 guanine/thymine mispair binding(GO:0032137)
0.2 1.1 GO:0052654 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.2 0.5 GO:0015068 amidinotransferase activity(GO:0015067) glycine amidinotransferase activity(GO:0015068)
0.1 0.4 GO:0050613 delta14-sterol reductase activity(GO:0050613)
0.1 0.7 GO:0047374 methylumbelliferyl-acetate deacetylase activity(GO:0047374)
0.1 1.0 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.0 0.6 GO:0070700 BMP receptor binding(GO:0070700)
0.0 1.2 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 1.3 GO:0051879 Hsp90 protein binding(GO:0051879)
0.0 0.5 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.3 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
0.0 0.6 GO:0070182 DNA polymerase binding(GO:0070182)
0.0 0.8 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0 0.8 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 0.9 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 1.2 GO:0002039 p53 binding(GO:0002039)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.3 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 0.7 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 1.3 PID CASPASE PATHWAY Caspase cascade in apoptosis

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.1 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.0 1.1 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 1.2 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 1.3 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 1.3 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 2.8 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.0 1.8 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 1.5 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.0 0.7 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 0.3 REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.0 0.4 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.3 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins