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SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for RAD21_SMC3

Z-value: 0.75

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Transcription factors associated with RAD21_SMC3

Gene Symbol Gene ID Gene Info
RAD21
ENSG00000164754.8 RAD21 cohesin complex component
SMC3
ENSG00000108055.9 structural maintenance of chromosomes 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
RAD21hg19_v2_chr8_-_117886612_117886673-0.126.0e-01Click!
SMC3hg19_v2_chr10_+_112327425_112327516-0.126.3e-01Click!

Activity profile of RAD21_SMC3 motif

Sorted Z-values of RAD21_SMC3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr22_-_22901636 2.03 ENST00000406503.1
ENST00000439106.1
ENST00000402697.1
ENST00000543184.1
ENST00000398743.2
PRAME
preferentially expressed antigen in melanoma
chr9_+_130965651 1.94 ENST00000475805.1
ENST00000341179.7
ENST00000372923.3
DNM1
dynamin 1
chr22_-_22901477 1.89 ENST00000420709.1
ENST00000398741.1
ENST00000405655.3
PRAME
preferentially expressed antigen in melanoma
chr10_-_76995675 1.80 ENST00000469299.1
COMTD1
catechol-O-methyltransferase domain containing 1
chr12_-_7245125 1.74 ENST00000542285.1
ENST00000540610.1
C1R
complement component 1, r subcomponent
chr9_+_130965677 1.73 ENST00000393594.3
ENST00000486160.1
DNM1
dynamin 1
chr11_+_61520075 1.65 ENST00000278836.5
MYRF
myelin regulatory factor
chr12_-_7245018 1.59 ENST00000543835.1
ENST00000535233.2
C1R
complement component 1, r subcomponent
chr15_+_45722727 1.58 ENST00000396650.2
ENST00000558435.1
ENST00000344300.3
C15orf48
chromosome 15 open reading frame 48
chr10_-_76995769 1.57 ENST00000372538.3
COMTD1
catechol-O-methyltransferase domain containing 1
chr8_-_48651648 1.56 ENST00000408965.3
CEBPD
CCAAT/enhancer binding protein (C/EBP), delta
chr12_-_7245080 1.46 ENST00000541042.1
ENST00000540242.1
C1R
complement component 1, r subcomponent
chr12_-_7245152 1.42 ENST00000542220.2
C1R
complement component 1, r subcomponent
chr17_+_74864476 1.36 ENST00000301618.4
ENST00000569840.2
MGAT5B
mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B
chr16_-_2390704 1.35 ENST00000301732.5
ENST00000382381.3
ABCA3
ATP-binding cassette, sub-family A (ABC1), member 3
chr16_+_30996502 1.34 ENST00000353250.5
ENST00000262520.6
ENST00000297679.5
ENST00000562932.1
ENST00000574447.1
HSD3B7
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
chr17_+_43213004 1.28 ENST00000586346.1
ENST00000398322.3
ENST00000592162.1
ENST00000376955.4
ENST00000321854.8
ACBD4
acyl-CoA binding domain containing 4
chr19_+_38893809 1.25 ENST00000589408.1
FAM98C
family with sequence similarity 98, member C
chr2_+_27309605 1.24 ENST00000260599.6
ENST00000260598.5
ENST00000429697.1
KHK
ketohexokinase (fructokinase)
chr8_-_27850180 1.23 ENST00000380385.2
ENST00000301906.4
ENST00000354914.3
SCARA5
scavenger receptor class A, member 5 (putative)
chr11_-_65150103 1.19 ENST00000294187.6
ENST00000398802.1
ENST00000360662.3
ENST00000377152.2
ENST00000530936.1
SLC25A45
solute carrier family 25, member 45
chr20_-_34542548 1.17 ENST00000305978.2
SCAND1
SCAN domain containing 1
chr2_+_234263120 1.16 ENST00000264057.2
ENST00000427930.1
DGKD
diacylglycerol kinase, delta 130kDa
chrX_-_30326445 1.09 ENST00000378963.1
NR0B1
nuclear receptor subfamily 0, group B, member 1
chr19_-_49339080 1.08 ENST00000595764.1
HSD17B14
hydroxysteroid (17-beta) dehydrogenase 14
chr9_+_140317802 1.07 ENST00000341349.2
ENST00000392815.2
NOXA1
NADPH oxidase activator 1
chr19_-_3547305 1.05 ENST00000589063.1
MFSD12
major facilitator superfamily domain containing 12
chr8_+_22446763 1.03 ENST00000450780.2
ENST00000430850.2
ENST00000447849.1
AC037459.4
Uncharacterized protein
chr20_+_48807351 0.99 ENST00000303004.3
CEBPB
CCAAT/enhancer binding protein (C/EBP), beta
chr19_-_33793430 0.98 ENST00000498907.2
CEBPA
CCAAT/enhancer binding protein (C/EBP), alpha
chr16_-_19897455 0.93 ENST00000568214.1
ENST00000569479.1
GPRC5B
G protein-coupled receptor, family C, group 5, member B
chr2_+_20866424 0.92 ENST00000272224.3
GDF7
growth differentiation factor 7
chr17_-_33446820 0.85 ENST00000592577.1
ENST00000590016.1
ENST00000345365.6
ENST00000360276.3
ENST00000357906.3
RAD51D
RAD51 paralog D
chr5_+_176513895 0.84 ENST00000503708.1
ENST00000393648.2
ENST00000514472.1
ENST00000502906.1
ENST00000292410.3
ENST00000510911.1
FGFR4
fibroblast growth factor receptor 4
chr17_+_48556158 0.82 ENST00000258955.2
RSAD1
radical S-adenosyl methionine domain containing 1
chr16_+_230435 0.82 ENST00000199708.2
HBQ1
hemoglobin, theta 1
chr19_-_55652290 0.81 ENST00000589745.1
TNNT1
troponin T type 1 (skeletal, slow)
chr16_+_89642120 0.80 ENST00000268720.5
ENST00000319518.8
CPNE7
copine VII
chr19_+_38893751 0.80 ENST00000588262.1
ENST00000252530.5
ENST00000343358.7
FAM98C
family with sequence similarity 98, member C
chr4_-_164253738 0.79 ENST00000509586.1
ENST00000504391.1
ENST00000512819.1
NPY1R
neuropeptide Y receptor Y1
chr5_+_175299743 0.79 ENST00000502265.1
CPLX2
complexin 2
chr11_+_60691924 0.79 ENST00000544065.1
ENST00000453848.2
ENST00000005286.4
TMEM132A
transmembrane protein 132A
chr1_+_212208919 0.79 ENST00000366991.4
ENST00000542077.1
DTL
denticleless E3 ubiquitin protein ligase homolog (Drosophila)
chr6_-_11044509 0.77 ENST00000354666.3
ELOVL2
ELOVL fatty acid elongase 2
chr22_-_30783075 0.77 ENST00000215798.6
RNF215
ring finger protein 215
chr7_+_73082152 0.77 ENST00000324941.4
ENST00000451519.1
VPS37D
vacuolar protein sorting 37 homolog D (S. cerevisiae)
chr17_-_33446735 0.76 ENST00000460118.2
ENST00000335858.7
RAD51D
RAD51 paralog D
chr9_-_139258235 0.75 ENST00000371738.3
DNLZ
DNL-type zinc finger
chr19_+_5823813 0.74 ENST00000303212.2
NRTN
neurturin
chr5_+_140254884 0.73 ENST00000398631.2
PCDHA12
protocadherin alpha 12
chr17_-_42441204 0.72 ENST00000293443.7
FAM171A2
family with sequence similarity 171, member A2
chr6_-_32920794 0.70 ENST00000395305.3
ENST00000395303.3
ENST00000374843.4
ENST00000429234.1
HLA-DMA
XXbac-BPG181M17.5
major histocompatibility complex, class II, DM alpha
Uncharacterized protein
chr5_+_176513868 0.70 ENST00000292408.4
FGFR4
fibroblast growth factor receptor 4
chr8_-_145911188 0.70 ENST00000540274.1
ARHGAP39
Rho GTPase activating protein 39
chr9_-_139940608 0.70 ENST00000371601.4
NPDC1
neural proliferation, differentiation and control, 1
chr7_-_27219849 0.70 ENST00000396344.4
HOXA10
homeobox A10
chr16_+_75032901 0.69 ENST00000335325.4
ENST00000320619.6
ZNRF1
zinc and ring finger 1, E3 ubiquitin protein ligase
chr11_+_2421718 0.69 ENST00000380996.5
ENST00000333256.6
ENST00000380992.1
ENST00000437110.1
ENST00000435795.1
TSSC4
tumor suppressing subtransferable candidate 4
chr11_-_407103 0.68 ENST00000526395.1
SIGIRR
single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
chr1_+_840205 0.67 ENST00000607769.1
RP11-54O7.16
RP11-54O7.16
chr1_+_37940153 0.66 ENST00000373087.6
ZC3H12A
zinc finger CCCH-type containing 12A
chr8_+_17434689 0.66 ENST00000398074.3
PDGFRL
platelet-derived growth factor receptor-like
chr8_-_145669791 0.66 ENST00000409379.3
TONSL
tonsoku-like, DNA repair protein
chr6_+_160769399 0.65 ENST00000392145.1
SLC22A3
solute carrier family 22 (organic cation transporter), member 3
chrX_-_153279697 0.65 ENST00000444254.1
IRAK1
interleukin-1 receptor-associated kinase 1
chr17_-_19266045 0.64 ENST00000395616.3
B9D1
B9 protein domain 1
chr11_-_8285405 0.64 ENST00000335790.3
ENST00000534484.1
LMO1
LIM domain only 1 (rhombotin 1)
chr20_+_3801162 0.64 ENST00000379573.2
ENST00000379567.2
ENST00000455742.1
ENST00000246041.2
AP5S1
adaptor-related protein complex 5, sigma 1 subunit
chr17_-_73511584 0.63 ENST00000321617.3
CASKIN2
CASK interacting protein 2
chr6_+_138188351 0.62 ENST00000421450.1
TNFAIP3
tumor necrosis factor, alpha-induced protein 3
chr22_-_22292934 0.61 ENST00000538191.1
ENST00000424647.1
ENST00000407142.1
PPM1F
protein phosphatase, Mg2+/Mn2+ dependent, 1F
chr16_-_2379688 0.61 ENST00000567910.1
ABCA3
ATP-binding cassette, sub-family A (ABC1), member 3
chr2_+_228678550 0.60 ENST00000409189.3
ENST00000358813.4
CCL20
chemokine (C-C motif) ligand 20
chr16_+_30406721 0.60 ENST00000320159.2
ZNF48
zinc finger protein 48
chr8_-_27850141 0.58 ENST00000524352.1
SCARA5
scavenger receptor class A, member 5 (putative)
chr21_-_44846999 0.57 ENST00000270162.6
SIK1
salt-inducible kinase 1
chr20_-_33460621 0.57 ENST00000427420.1
ENST00000336431.5
GGT7
gamma-glutamyltransferase 7
chr17_+_7591639 0.56 ENST00000396463.2
WRAP53
WD repeat containing, antisense to TP53
chr3_-_142607740 0.56 ENST00000485766.1
PCOLCE2
procollagen C-endopeptidase enhancer 2
chr17_-_48277552 0.56 ENST00000507689.1
COL1A1
collagen, type I, alpha 1
chr17_-_36891830 0.56 ENST00000578487.1
PCGF2
polycomb group ring finger 2
chr17_+_7591747 0.55 ENST00000534050.1
WRAP53
WD repeat containing, antisense to TP53
chr10_-_47151341 0.55 ENST00000422732.2
LINC00842
long intergenic non-protein coding RNA 842
chr7_-_45957011 0.55 ENST00000417621.1
IGFBP3
insulin-like growth factor binding protein 3
chr19_+_41313017 0.55 ENST00000595621.1
ENST00000595051.1
EGLN2
egl-9 family hypoxia-inducible factor 2
chr19_-_38747172 0.55 ENST00000347262.4
ENST00000591585.1
ENST00000301242.4
PPP1R14A
protein phosphatase 1, regulatory (inhibitor) subunit 14A
chr12_-_49730970 0.55 ENST00000334221.3
C1QL4
complement component 1, q subcomponent-like 4
chr22_-_30783356 0.55 ENST00000382363.3
RNF215
ring finger protein 215
chr15_-_64338521 0.54 ENST00000457488.1
ENST00000558069.1
DAPK2
death-associated protein kinase 2
chr14_-_23292596 0.54 ENST00000554741.1
SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr3_+_48507210 0.54 ENST00000433541.1
ENST00000422277.2
ENST00000436480.2
ENST00000444177.1
TREX1
three prime repair exonuclease 1
chr22_-_24316648 0.54 ENST00000403754.3
ENST00000430101.2
ENST00000398344.4
DDT
D-dopachrome tautomerase
chr17_-_76183111 0.53 ENST00000405273.1
ENST00000590862.1
ENST00000590430.1
ENST00000586613.1
TK1
thymidine kinase 1, soluble
chr7_+_302918 0.53 ENST00000599994.1
AC187652.1
Protein LOC100996433
chr16_+_29827285 0.52 ENST00000320330.6
PAGR1
PAXIP1 associated glutamate-rich protein 1
chr16_+_84002234 0.51 ENST00000305202.4
NECAB2
N-terminal EF-hand calcium binding protein 2
chr2_+_113342163 0.51 ENST00000409719.1
CHCHD5
coiled-coil-helix-coiled-coil-helix domain containing 5
chr1_+_203830703 0.50 ENST00000414487.2
SNRPE
small nuclear ribonucleoprotein polypeptide E
chr19_-_55653259 0.50 ENST00000593194.1
TNNT1
troponin T type 1 (skeletal, slow)
chr12_+_58176525 0.49 ENST00000543727.1
ENST00000540550.1
ENST00000323833.8
ENST00000350762.5
ENST00000550559.1
ENST00000548851.1
ENST00000434359.1
ENST00000457189.1
TSFM
Ts translation elongation factor, mitochondrial
chr16_+_1203194 0.49 ENST00000348261.5
ENST00000358590.4
CACNA1H
calcium channel, voltage-dependent, T type, alpha 1H subunit
chr14_+_105957402 0.49 ENST00000421892.1
ENST00000334656.7
ENST00000451719.1
ENST00000392522.3
ENST00000392523.4
ENST00000354560.6
ENST00000450383.1
C14orf80
chromosome 14 open reading frame 80
chr2_-_24307635 0.48 ENST00000313482.4
TP53I3
tumor protein p53 inducible protein 3
chr7_+_6655225 0.48 ENST00000457543.3
ZNF853
zinc finger protein 853
chr4_+_2043777 0.48 ENST00000409860.1
C4orf48
chromosome 4 open reading frame 48
chr4_+_2043689 0.48 ENST00000382878.3
ENST00000409248.4
C4orf48
chromosome 4 open reading frame 48
chr17_+_63096903 0.48 ENST00000582940.1
RP11-160O5.1
RP11-160O5.1
chr10_+_6622345 0.47 ENST00000445427.1
ENST00000455810.1
PRKCQ-AS1
PRKCQ antisense RNA 1
chr7_-_45956856 0.46 ENST00000428530.1
IGFBP3
insulin-like growth factor binding protein 3
chr17_-_34890732 0.46 ENST00000268852.9
MYO19
myosin XIX
chr9_+_131901710 0.46 ENST00000524946.2
PPP2R4
protein phosphatase 2A activator, regulatory subunit 4
chr9_+_131901661 0.45 ENST00000423100.1
PPP2R4
protein phosphatase 2A activator, regulatory subunit 4
chr9_+_139738867 0.45 ENST00000436881.1
C9orf172
chromosome 9 open reading frame 172
chr17_-_73901494 0.45 ENST00000309352.3
MRPL38
mitochondrial ribosomal protein L38
chr19_+_49496705 0.45 ENST00000595090.1
RUVBL2
RuvB-like AAA ATPase 2
chr16_+_29827832 0.45 ENST00000609618.1
PAGR1
PAXIP1-associated glutamate-rich protein 1
chr11_-_65149422 0.45 ENST00000526432.1
ENST00000527174.1
SLC25A45
solute carrier family 25, member 45
chr12_-_8549301 0.44 ENST00000544461.1
LINC00937
long intergenic non-protein coding RNA 937
chr1_-_172413195 0.44 ENST00000344529.4
PIGC
phosphatidylinositol glycan anchor biosynthesis, class C
chr9_-_139258159 0.44 ENST00000371739.3
DNLZ
DNL-type zinc finger
chr17_-_33469299 0.44 ENST00000586869.1
ENST00000360831.5
ENST00000442241.4
NLE1
notchless homolog 1 (Drosophila)
chr2_-_72375167 0.43 ENST00000001146.2
CYP26B1
cytochrome P450, family 26, subfamily B, polypeptide 1
chr17_+_76356516 0.43 ENST00000592569.1
RP11-806H10.4
RP11-806H10.4
chr10_+_99332198 0.43 ENST00000307518.5
ENST00000298808.5
ENST00000370655.1
ANKRD2
ankyrin repeat domain 2 (stretch responsive muscle)
chr16_+_30759700 0.42 ENST00000328273.7
PHKG2
phosphorylase kinase, gamma 2 (testis)
chr17_-_34890759 0.41 ENST00000431794.3
MYO19
myosin XIX
chr1_-_139379 0.41 ENST00000423372.3
AL627309.1
Uncharacterized protein
chr10_+_104154229 0.41 ENST00000428099.1
ENST00000369966.3
NFKB2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
chr2_-_24307162 0.40 ENST00000413037.1
ENST00000407482.1
TP53I3
tumor protein p53 inducible protein 3
chr19_-_40030861 0.40 ENST00000390658.2
EID2
EP300 interacting inhibitor of differentiation 2
chr8_-_11873043 0.40 ENST00000527396.1
RP11-481A20.11
Protein LOC101060662
chr9_+_139560197 0.40 ENST00000371698.3
EGFL7
EGF-like-domain, multiple 7
chr8_-_145550571 0.40 ENST00000332324.4
DGAT1
diacylglycerol O-acyltransferase 1
chr12_+_104609550 0.39 ENST00000525566.1
ENST00000429002.2
TXNRD1
thioredoxin reductase 1
chr20_+_43992094 0.39 ENST00000453003.1
SYS1
SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae)
chr9_+_36136700 0.39 ENST00000396613.3
ENST00000377959.1
ENST00000377960.4
GLIPR2
GLI pathogenesis-related 2
chr4_-_141348999 0.39 ENST00000325617.5
CLGN
calmegin
chr2_+_69240415 0.39 ENST00000409829.3
ANTXR1
anthrax toxin receptor 1
chr19_+_49496782 0.39 ENST00000601968.1
ENST00000596837.1
RUVBL2
RuvB-like AAA ATPase 2
chr14_-_75079294 0.39 ENST00000556359.1
LTBP2
latent transforming growth factor beta binding protein 2
chr9_+_34646651 0.39 ENST00000378842.3
GALT
galactose-1-phosphate uridylyltransferase
chr19_+_47852538 0.39 ENST00000328771.4
DHX34
DEAH (Asp-Glu-Ala-His) box polypeptide 34
chr9_+_34646624 0.39 ENST00000450095.2
ENST00000556278.1
GALT
GALT
galactose-1-phosphate uridylyltransferase
Uncharacterized protein
chr11_+_73000449 0.38 ENST00000535931.1
P2RY6
pyrimidinergic receptor P2Y, G-protein coupled, 6
chr19_-_59030921 0.38 ENST00000354590.3
ENST00000596739.1
ZBTB45
zinc finger and BTB domain containing 45
chr3_-_128212016 0.38 ENST00000498200.1
ENST00000341105.2
GATA2
GATA binding protein 2
chr2_+_69240511 0.38 ENST00000409349.3
ANTXR1
anthrax toxin receptor 1
chr2_+_228336849 0.38 ENST00000409979.2
ENST00000310078.8
AGFG1
ArfGAP with FG repeats 1
chr19_+_12949251 0.38 ENST00000251472.4
MAST1
microtubule associated serine/threonine kinase 1
chr2_+_239067597 0.37 ENST00000546354.1
FAM132B
family with sequence similarity 132, member B
chr5_+_176514413 0.37 ENST00000513166.1
FGFR4
fibroblast growth factor receptor 4
chr12_-_121410095 0.37 ENST00000539163.1
AC079602.1
AC079602.1
chr17_+_17584763 0.37 ENST00000353383.1
RAI1
retinoic acid induced 1
chr9_-_38069208 0.37 ENST00000377707.3
ENST00000377700.4
SHB
Src homology 2 domain containing adaptor protein B
chr9_-_140317676 0.37 ENST00000342129.4
ENST00000340951.4
EXD3
exonuclease 3'-5' domain containing 3
chr1_-_211307404 0.37 ENST00000367007.4
KCNH1
potassium voltage-gated channel, subfamily H (eag-related), member 1
chr2_+_69240302 0.36 ENST00000303714.4
ANTXR1
anthrax toxin receptor 1
chr1_-_172413226 0.36 ENST00000367728.1
ENST00000258324.1
PIGC
phosphatidylinositol glycan anchor biosynthesis, class C
chr14_-_93582214 0.36 ENST00000556603.2
ENST00000354313.3
ITPK1
inositol-tetrakisphosphate 1-kinase
chr17_-_19265982 0.36 ENST00000268841.6
ENST00000261499.4
ENST00000575478.1
B9D1
B9 protein domain 1
chr2_-_74710078 0.36 ENST00000290418.4
CCDC142
coiled-coil domain containing 142
chr19_+_41860047 0.36 ENST00000604123.1
TMEM91
transmembrane protein 91
chr16_-_88851618 0.35 ENST00000301015.9
PIEZO1
piezo-type mechanosensitive ion channel component 1
chr17_+_73996987 0.35 ENST00000588812.1
ENST00000448471.1
CDK3
cyclin-dependent kinase 3
chr6_+_33359582 0.35 ENST00000450504.1
KIFC1
kinesin family member C1
chr4_-_140216948 0.35 ENST00000265500.4
NDUFC1
NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa
chr17_+_38137050 0.35 ENST00000264639.4
PSMD3
proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
chr9_+_131903916 0.35 ENST00000419582.1
PPP2R4
protein phosphatase 2A activator, regulatory subunit 4
chr19_-_38746979 0.34 ENST00000591291.1
PPP1R14A
protein phosphatase 1, regulatory (inhibitor) subunit 14A
chr2_-_220025263 0.34 ENST00000457600.1
NHEJ1
nonhomologous end-joining factor 1
chr19_+_49977466 0.34 ENST00000596435.1
ENST00000344019.3
ENST00000597551.1
ENST00000204637.2
ENST00000600429.1
FLT3LG
fms-related tyrosine kinase 3 ligand
chr10_+_17272608 0.34 ENST00000421459.2
VIM
vimentin
chr14_-_93582148 0.33 ENST00000267615.6
ENST00000553452.1
ITPK1
inositol-tetrakisphosphate 1-kinase
chr19_+_41699103 0.33 ENST00000597754.1
CYP2S1
cytochrome P450, family 2, subfamily S, polypeptide 1
chr19_+_36027660 0.33 ENST00000585510.1
GAPDHS
glyceraldehyde-3-phosphate dehydrogenase, spermatogenic
chr16_-_66907139 0.33 ENST00000561579.2
NAE1
NEDD8 activating enzyme E1 subunit 1
chr17_+_73629500 0.33 ENST00000375215.3
SMIM5
small integral membrane protein 5
chr14_-_54908043 0.33 ENST00000556113.1
ENST00000553660.1
ENST00000395573.4
ENST00000557690.1
ENST00000216416.4
CNIH1
cornichon family AMPA receptor auxiliary protein 1
chr9_-_35096545 0.32 ENST00000378617.3
ENST00000341666.3
ENST00000361778.2
PIGO
phosphatidylinositol glycan anchor biosynthesis, class O
chr10_+_81107216 0.32 ENST00000394579.3
ENST00000225174.3
PPIF
peptidylprolyl isomerase F
chr12_-_7261772 0.32 ENST00000545280.1
ENST00000543933.1
ENST00000545337.1
ENST00000544702.1
ENST00000266542.4
C1RL
complement component 1, r subcomponent-like
chr16_-_30441293 0.32 ENST00000565758.1
ENST00000567983.1
ENST00000319285.4
DCTPP1
dCTP pyrophosphatase 1
chr4_-_141348789 0.32 ENST00000414773.1
CLGN
calmegin
chr8_-_11325047 0.32 ENST00000531804.1
FAM167A
family with sequence similarity 167, member A
chr14_+_24630465 0.32 ENST00000557894.1
ENST00000559284.1
ENST00000560275.1
IRF9
interferon regulatory factor 9
chr16_-_790982 0.32 ENST00000301694.5
ENST00000251588.2
NARFL
nuclear prelamin A recognition factor-like
chr19_+_8478154 0.32 ENST00000381035.4
ENST00000595142.1
ENST00000601724.1
ENST00000393944.1
ENST00000215555.2
ENST00000601283.1
ENST00000595213.1
MARCH2
membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase
chr17_-_1090599 0.31 ENST00000544583.2
ABR
active BCR-related
chr16_+_30759844 0.31 ENST00000565897.1
PHKG2
phosphorylase kinase, gamma 2 (testis)
chr19_+_56165480 0.31 ENST00000450554.2
U2AF2
U2 small nuclear RNA auxiliary factor 2
chr7_+_75831181 0.30 ENST00000388802.4
ENST00000326382.8
SRRM3
serine/arginine repetitive matrix 3
chr15_-_34502278 0.30 ENST00000559515.1
ENST00000256544.3
ENST00000560108.1
ENST00000559462.1
KATNBL1
katanin p80 subunit B-like 1
chr9_-_123239632 0.30 ENST00000416449.1
CDK5RAP2
CDK5 regulatory subunit associated protein 2
chr9_+_133884469 0.30 ENST00000361069.4
LAMC3
laminin, gamma 3
chr2_-_20850813 0.30 ENST00000402541.1
ENST00000406618.3
ENST00000304031.3
HS1BP3
HCLS1 binding protein 3
chr17_-_19265855 0.30 ENST00000440841.1
ENST00000395615.1
ENST00000461069.2
B9D1
B9 protein domain 1
chr5_-_146833222 0.30 ENST00000534907.1
DPYSL3
dihydropyrimidinase-like 3
chr7_-_16840820 0.29 ENST00000450569.1
AGR2
anterior gradient 2
chr15_-_26108355 0.29 ENST00000356865.6
ATP10A
ATPase, class V, type 10A
chr7_+_89783689 0.29 ENST00000297205.2
STEAP1
six transmembrane epithelial antigen of the prostate 1

Network of associatons between targets according to the STRING database.

First level regulatory network of RAD21_SMC3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 3.7 GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185)
0.4 1.1 GO:1901202 negative regulation of extracellular matrix assembly(GO:1901202)
0.4 1.1 GO:0032203 telomere formation via telomerase(GO:0032203)
0.3 1.9 GO:1903412 response to bile acid(GO:1903412)
0.3 0.8 GO:0006258 UDP-glucose catabolic process(GO:0006258)
0.2 4.4 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.2 0.7 GO:2000627 regulation of miRNA catabolic process(GO:2000625) positive regulation of miRNA catabolic process(GO:2000627)
0.2 0.6 GO:0046013 regulation of T cell homeostatic proliferation(GO:0046013)
0.2 1.2 GO:0006001 fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624)
0.2 1.6 GO:0000066 mitochondrial ornithine transport(GO:0000066)
0.2 0.6 GO:0045362 regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362)
0.2 1.6 GO:0000707 meiotic DNA recombinase assembly(GO:0000707)
0.2 0.7 GO:0002501 peptide antigen assembly with MHC protein complex(GO:0002501) peptide antigen assembly with MHC class II protein complex(GO:0002503)
0.2 0.8 GO:0090202 transcriptional activation by promoter-enhancer looping(GO:0071733) gene looping(GO:0090202) dsDNA loop formation(GO:0090579)
0.2 0.9 GO:0035992 tendon cell differentiation(GO:0035990) tendon formation(GO:0035992)
0.1 1.3 GO:0031444 slow-twitch skeletal muscle fiber contraction(GO:0031444)
0.1 1.7 GO:0032286 central nervous system myelin maintenance(GO:0032286)
0.1 0.6 GO:0044691 tooth eruption(GO:0044691)
0.1 0.5 GO:0060168 positive regulation of adenosine receptor signaling pathway(GO:0060168) regulation of G-protein coupled receptor internalization(GO:1904020)
0.1 0.4 GO:0010725 regulation of primitive erythrocyte differentiation(GO:0010725) eosinophil fate commitment(GO:0035854)
0.1 0.4 GO:0033634 positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
0.1 0.6 GO:0032792 negative regulation of CREB transcription factor activity(GO:0032792)
0.1 1.3 GO:0035754 B cell chemotaxis(GO:0035754)
0.1 0.3 GO:2000276 negative regulation of oxidative phosphorylation uncoupler activity(GO:2000276)
0.1 0.9 GO:0003065 positive regulation of heart rate by epinephrine(GO:0003065)
0.1 0.7 GO:0045819 positive regulation of glycogen catabolic process(GO:0045819)
0.1 0.4 GO:0002268 follicular dendritic cell differentiation(GO:0002268)
0.1 0.7 GO:0045079 negative regulation of chemokine biosynthetic process(GO:0045079)
0.1 0.5 GO:2000418 positive regulation of eosinophil migration(GO:2000418)
0.1 0.6 GO:0046104 thymidine metabolic process(GO:0046104) pyrimidine deoxyribonucleoside metabolic process(GO:0046125)
0.1 0.3 GO:0034147 regulation of toll-like receptor 5 signaling pathway(GO:0034147) negative regulation of toll-like receptor 5 signaling pathway(GO:0034148) negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070429) tolerance induction to lipopolysaccharide(GO:0072573) negative regulation of CD40 signaling pathway(GO:2000349)
0.1 1.5 GO:0060263 regulation of respiratory burst(GO:0060263)
0.1 0.3 GO:1903774 positive regulation of viral budding via host ESCRT complex(GO:1903774)
0.1 0.4 GO:0007181 transforming growth factor beta receptor complex assembly(GO:0007181)
0.1 2.4 GO:0046339 diacylglycerol metabolic process(GO:0046339)
0.1 0.3 GO:0090289 regulation of osteoclast proliferation(GO:0090289)
0.1 0.2 GO:0002588 positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002582) positive regulation of antigen processing and presentation of peptide antigen(GO:0002585) positive regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002588)
0.1 0.2 GO:0001994 norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure(GO:0001994)
0.1 0.7 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.1 0.3 GO:0018312 peptidyl-serine ADP-ribosylation(GO:0018312)
0.1 0.8 GO:0044387 negative regulation of protein kinase activity by regulation of protein phosphorylation(GO:0044387)
0.1 1.0 GO:0000050 urea cycle(GO:0000050)
0.1 0.3 GO:0072429 response to intra-S DNA damage checkpoint signaling(GO:0072429)
0.1 1.1 GO:0030238 male sex determination(GO:0030238)
0.1 1.0 GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440)
0.1 6.4 GO:0006958 complement activation, classical pathway(GO:0006958)
0.1 0.8 GO:0034625 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.1 0.3 GO:0009149 pyrimidine nucleoside triphosphate catabolic process(GO:0009149) pyrimidine deoxyribonucleoside triphosphate catabolic process(GO:0009213)
0.1 0.4 GO:0061484 hematopoietic stem cell homeostasis(GO:0061484)
0.1 0.2 GO:1901069 guanosine-containing compound catabolic process(GO:1901069)
0.1 0.6 GO:0010989 negative regulation of low-density lipoprotein particle clearance(GO:0010989)
0.1 0.3 GO:1903613 regulation of protein tyrosine phosphatase activity(GO:1903613) positive regulation of protein tyrosine phosphatase activity(GO:1903615)
0.1 0.3 GO:1904158 axonemal central apparatus assembly(GO:1904158)
0.1 0.1 GO:2001022 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517) positive regulation of response to DNA damage stimulus(GO:2001022)
0.1 0.5 GO:0035865 cellular response to potassium ion(GO:0035865)
0.1 0.4 GO:1900194 negative regulation of oocyte maturation(GO:1900194)
0.1 0.3 GO:0002032 desensitization of G-protein coupled receptor protein signaling pathway by arrestin(GO:0002032)
0.1 1.2 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.1 0.1 GO:0060406 positive regulation of penile erection(GO:0060406)
0.1 0.4 GO:0032383 regulation of intracellular lipid transport(GO:0032377) regulation of intracellular sterol transport(GO:0032380) regulation of intracellular cholesterol transport(GO:0032383)
0.0 0.5 GO:1990822 basic amino acid transmembrane transport(GO:1990822)
0.0 1.1 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.0 2.0 GO:0034755 iron ion transmembrane transport(GO:0034755)
0.0 1.1 GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568)
0.0 1.0 GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway(GO:0033148)
0.0 0.2 GO:0035712 T-helper 2 cell activation(GO:0035712) regulation of T-helper 2 cell activation(GO:2000569) positive regulation of T-helper 2 cell activation(GO:2000570)
0.0 0.3 GO:0043314 negative regulation of neutrophil degranulation(GO:0043314)
0.0 0.6 GO:0032364 oxygen homeostasis(GO:0032364)
0.0 0.8 GO:0015671 oxygen transport(GO:0015671)
0.0 0.3 GO:0030037 actin filament reorganization involved in cell cycle(GO:0030037)
0.0 0.2 GO:0097155 fasciculation of sensory neuron axon(GO:0097155)
0.0 0.6 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.0 0.3 GO:0045716 positive regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045716)
0.0 0.3 GO:1903899 lung goblet cell differentiation(GO:0060480) positive regulation of PERK-mediated unfolded protein response(GO:1903899)
0.0 0.1 GO:2000819 regulation of nucleotide-excision repair(GO:2000819)
0.0 1.8 GO:0090140 regulation of mitochondrial fission(GO:0090140)
0.0 0.7 GO:0034134 toll-like receptor 2 signaling pathway(GO:0034134)
0.0 0.7 GO:0032957 inositol trisphosphate metabolic process(GO:0032957)
0.0 0.1 GO:1903027 regulation of opsonization(GO:1903027) positive regulation of opsonization(GO:1903028)
0.0 0.7 GO:0051608 histamine transport(GO:0051608)
0.0 0.1 GO:0032827 negative regulation of natural killer cell differentiation(GO:0032824) negative regulation of natural killer cell differentiation involved in immune response(GO:0032827)
0.0 0.9 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
0.0 0.9 GO:0060907 positive regulation of macrophage cytokine production(GO:0060907)
0.0 0.1 GO:1901421 positive regulation of response to alcohol(GO:1901421)
0.0 0.1 GO:0002428 antigen processing and presentation of peptide antigen via MHC class Ib(GO:0002428) antigen processing and presentation of endogenous peptide antigen via MHC class Ib(GO:0002476)
0.0 0.3 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.0 0.2 GO:1902715 secretory granule localization(GO:0032252) positive regulation of interferon-gamma secretion(GO:1902715)
0.0 0.1 GO:0006424 glutamyl-tRNA aminoacylation(GO:0006424)
0.0 0.6 GO:1901750 leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750)
0.0 0.2 GO:0045591 positive regulation of regulatory T cell differentiation(GO:0045591)
0.0 0.6 GO:0033617 mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.0 0.2 GO:0060154 cellular process regulating host cell cycle in response to virus(GO:0060154)
0.0 0.4 GO:0001887 selenium compound metabolic process(GO:0001887)
0.0 0.1 GO:0018282 metal incorporation into metallo-sulfur cluster(GO:0018282) iron incorporation into metallo-sulfur cluster(GO:0018283)
0.0 0.3 GO:2000623 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.0 0.4 GO:0070307 lens fiber cell development(GO:0070307)
0.0 0.5 GO:0070129 regulation of mitochondrial translation(GO:0070129)
0.0 0.2 GO:0045163 clustering of voltage-gated potassium channels(GO:0045163)
0.0 0.3 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.0 0.1 GO:2000721 positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation(GO:2000721)
0.0 0.6 GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0043619)
0.0 0.1 GO:0038161 prolactin signaling pathway(GO:0038161)
0.0 0.7 GO:0035791 platelet-derived growth factor receptor-beta signaling pathway(GO:0035791)
0.0 0.2 GO:0035511 oxidative DNA demethylation(GO:0035511)
0.0 0.2 GO:0030174 regulation of DNA-dependent DNA replication initiation(GO:0030174)
0.0 0.8 GO:0039702 viral budding via host ESCRT complex(GO:0039702)
0.0 0.4 GO:0030321 transepithelial chloride transport(GO:0030321)
0.0 0.3 GO:0000055 ribosomal large subunit export from nucleus(GO:0000055) endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000447)
0.0 0.3 GO:0045919 positive regulation of cytolysis(GO:0045919)
0.0 0.2 GO:0002249 lymphocyte anergy(GO:0002249) regulation of T cell anergy(GO:0002667) T cell anergy(GO:0002870) regulation of lymphocyte anergy(GO:0002911)
0.0 0.3 GO:0046600 negative regulation of centriole replication(GO:0046600)
0.0 0.2 GO:0003431 growth plate cartilage chondrocyte development(GO:0003431)
0.0 0.4 GO:0001675 acrosome assembly(GO:0001675)
0.0 0.2 GO:0071316 cellular response to nicotine(GO:0071316)
0.0 0.7 GO:0060065 uterus development(GO:0060065)
0.0 0.4 GO:0045023 G0 to G1 transition(GO:0045023)
0.0 0.3 GO:0050861 positive regulation of B cell receptor signaling pathway(GO:0050861)
0.0 0.6 GO:0031915 positive regulation of synaptic plasticity(GO:0031915)
0.0 0.9 GO:0007339 binding of sperm to zona pellucida(GO:0007339)
0.0 0.3 GO:0043951 negative regulation of cAMP-mediated signaling(GO:0043951)
0.0 0.4 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.0 0.2 GO:0032494 response to peptidoglycan(GO:0032494)
0.0 0.8 GO:0006779 porphyrin-containing compound biosynthetic process(GO:0006779)
0.0 0.1 GO:1903232 melanosome assembly(GO:1903232)
0.0 0.6 GO:0031297 replication fork processing(GO:0031297)
0.0 0.2 GO:1902074 response to salt(GO:1902074)
0.0 0.2 GO:2000189 positive regulation of cholesterol homeostasis(GO:2000189)
0.0 0.2 GO:0042985 negative regulation of amyloid precursor protein biosynthetic process(GO:0042985)
0.0 0.1 GO:0006272 leading strand elongation(GO:0006272)
0.0 0.6 GO:0000042 protein targeting to Golgi(GO:0000042)
0.0 0.1 GO:1900019 embryonic genitalia morphogenesis(GO:0030538) regulation of protein kinase C activity(GO:1900019) positive regulation of protein kinase C activity(GO:1900020)
0.0 0.2 GO:0006049 UDP-N-acetylglucosamine catabolic process(GO:0006049)
0.0 0.3 GO:0045821 positive regulation of glycolytic process(GO:0045821) positive regulation of cofactor metabolic process(GO:0051194) positive regulation of coenzyme metabolic process(GO:0051197)
0.0 0.2 GO:0051152 positive regulation of smooth muscle cell differentiation(GO:0051152)
0.0 0.2 GO:0015808 L-alanine transport(GO:0015808)
0.0 0.1 GO:0034446 substrate adhesion-dependent cell spreading(GO:0034446)
0.0 0.1 GO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948)
0.0 1.6 GO:0045669 positive regulation of osteoblast differentiation(GO:0045669)
0.0 0.6 GO:0014002 astrocyte development(GO:0014002)
0.0 0.8 GO:0019228 neuronal action potential(GO:0019228)
0.0 0.2 GO:0071787 endoplasmic reticulum tubular network assembly(GO:0071787)
0.0 0.1 GO:1904100 regulation of protein O-linked glycosylation(GO:1904098) positive regulation of protein O-linked glycosylation(GO:1904100)
0.0 1.3 GO:0042733 embryonic digit morphogenesis(GO:0042733)
0.0 0.9 GO:0006739 NADP metabolic process(GO:0006739)
0.0 0.5 GO:0042438 melanin biosynthetic process(GO:0042438)
0.0 0.3 GO:0007021 tubulin complex assembly(GO:0007021)
0.0 0.2 GO:0042670 retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549)
0.0 0.8 GO:0042769 DNA damage response, detection of DNA damage(GO:0042769)
0.0 0.0 GO:0071529 cementum mineralization(GO:0071529)
0.0 0.3 GO:0019373 epoxygenase P450 pathway(GO:0019373)
0.0 0.1 GO:0045602 negative regulation of endothelial cell differentiation(GO:0045602)
0.0 1.2 GO:0071277 cellular response to calcium ion(GO:0071277)
0.0 0.1 GO:0051415 interphase microtubule nucleation by interphase microtubule organizing center(GO:0051415) microtubule nucleation by microtubule organizing center(GO:0051418)
0.0 0.1 GO:0060449 bud elongation involved in lung branching(GO:0060449)
0.0 0.1 GO:0014050 negative regulation of glutamate secretion(GO:0014050)
0.0 0.3 GO:0006506 GPI anchor metabolic process(GO:0006505) GPI anchor biosynthetic process(GO:0006506)
0.0 0.2 GO:0006002 fructose 6-phosphate metabolic process(GO:0006002) fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0 0.5 GO:0006298 mismatch repair(GO:0006298)
0.0 0.2 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.0 0.1 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.0 0.2 GO:0006293 nucleotide-excision repair, preincision complex stabilization(GO:0006293)
0.0 0.0 GO:0030241 skeletal muscle myosin thick filament assembly(GO:0030241)
0.0 0.0 GO:1904211 membrane protein proteolysis involved in retrograde protein transport, ER to cytosol(GO:1904211)
0.0 0.3 GO:0045332 phospholipid translocation(GO:0045332)
0.0 0.1 GO:0006572 tyrosine catabolic process(GO:0006572)
0.0 0.1 GO:0050868 negative regulation of T cell activation(GO:0050868) negative regulation of leukocyte cell-cell adhesion(GO:1903038)
0.0 1.1 GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway(GO:0007193)
0.0 0.4 GO:0051764 actin crosslink formation(GO:0051764)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.0 GO:0097233 lamellar body membrane(GO:0097232) alveolar lamellar body membrane(GO:0097233)
0.2 0.7 GO:0035101 FACT complex(GO:0035101)
0.2 1.6 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.2 2.1 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.2 0.6 GO:0005584 collagen type I trimer(GO:0005584)
0.1 0.6 GO:0045323 interleukin-1 receptor complex(GO:0045323)
0.1 0.4 GO:0033257 Bcl3/NF-kappaB2 complex(GO:0033257)
0.1 1.0 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.1 0.7 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.1 1.1 GO:0042788 polysomal ribosome(GO:0042788)
0.1 0.8 GO:0070033 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033) synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554)
0.1 0.8 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.1 0.8 GO:0097255 R2TP complex(GO:0097255)
0.1 0.8 GO:0005833 hemoglobin complex(GO:0005833)
0.1 0.7 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.1 0.6 GO:0097361 CIA complex(GO:0097361)
0.1 1.0 GO:0044666 MLL3/4 complex(GO:0044666)
0.1 0.3 GO:0048476 Holliday junction resolvase complex(GO:0048476)
0.1 0.5 GO:0034715 pICln-Sm protein complex(GO:0034715)
0.1 1.3 GO:0036038 MKS complex(GO:0036038)
0.1 1.3 GO:0005861 troponin complex(GO:0005861)
0.1 0.2 GO:0097134 Y chromosome(GO:0000806) cyclin A2-CDK2 complex(GO:0097124) cyclin E1-CDK2 complex(GO:0097134)
0.1 0.8 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.1 1.1 GO:0043020 NADPH oxidase complex(GO:0043020)
0.1 0.2 GO:0098855 HCN channel complex(GO:0098855)
0.1 0.6 GO:0001739 sex chromatin(GO:0001739)
0.0 0.3 GO:0032807 DNA ligase IV complex(GO:0032807)
0.0 0.4 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.0 0.5 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 0.3 GO:0089701 U2AF(GO:0089701)
0.0 3.2 GO:0001917 photoreceptor inner segment(GO:0001917)
0.0 0.3 GO:1990131 Gtr1-Gtr2 GTPase complex(GO:1990131)
0.0 0.9 GO:0032059 bleb(GO:0032059)
0.0 0.8 GO:0000813 ESCRT I complex(GO:0000813)
0.0 0.8 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 0.3 GO:0043196 varicosity(GO:0043196)
0.0 0.2 GO:0097149 centralspindlin complex(GO:0097149)
0.0 0.3 GO:0000120 RNA polymerase I transcription factor complex(GO:0000120)
0.0 0.7 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 0.2 GO:0072558 NLRP1 inflammasome complex(GO:0072558)
0.0 1.5 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 0.5 GO:0031931 TORC1 complex(GO:0031931)
0.0 6.3 GO:0072562 blood microparticle(GO:0072562)
0.0 0.2 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.0 0.1 GO:0031905 early endosome lumen(GO:0031905)
0.0 0.4 GO:0043190 ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.0 0.9 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.0 0.2 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 0.2 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.0 0.7 GO:0097431 mitotic spindle pole(GO:0097431)
0.0 0.2 GO:0031298 replication fork protection complex(GO:0031298)
0.0 0.2 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 0.1 GO:0016272 prefoldin complex(GO:0016272)
0.0 0.3 GO:0000815 ESCRT III complex(GO:0000815)
0.0 0.1 GO:0042825 TAP complex(GO:0042825)
0.0 0.2 GO:0033391 chromatoid body(GO:0033391)
0.0 0.1 GO:0034678 integrin alpha8-beta1 complex(GO:0034678)
0.0 0.2 GO:0005583 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.1 GO:0000923 equatorial microtubule organizing center(GO:0000923)
0.0 0.6 GO:0000791 euchromatin(GO:0000791)
0.0 0.8 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 0.0 GO:0034680 integrin alpha10-beta1 complex(GO:0034680)
0.0 1.3 GO:0016459 myosin complex(GO:0016459)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0008160 protein tyrosine phosphatase activator activity(GO:0008160)
0.2 0.9 GO:0001601 peptide YY receptor activity(GO:0001601)
0.2 1.6 GO:0000064 L-ornithine transmembrane transporter activity(GO:0000064)
0.2 0.7 GO:0052825 inositol tetrakisphosphate 1-kinase activity(GO:0047325) inositol-1,3,4-trisphosphate 6-kinase activity(GO:0052725) inositol-1,3,4-trisphosphate 5-kinase activity(GO:0052726) inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity(GO:0052825) inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity(GO:0052830) inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity(GO:0052831) inositol-3,4,6-trisphosphate 1-kinase activity(GO:0052835)
0.2 1.4 GO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
0.2 0.6 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.2 0.6 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)
0.2 1.3 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.2 1.8 GO:0060002 plus-end directed microfilament motor activity(GO:0060002)
0.2 0.7 GO:0005019 platelet-derived growth factor beta-receptor activity(GO:0005019)
0.2 0.5 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)
0.2 1.1 GO:0047045 testosterone 17-beta-dehydrogenase (NADP+) activity(GO:0047045)
0.1 1.8 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.1 0.5 GO:0033981 D-dopachrome decarboxylase activity(GO:0033981)
0.1 1.3 GO:0008158 hedgehog receptor activity(GO:0008158)
0.1 0.5 GO:0031685 adenosine receptor binding(GO:0031685)
0.1 0.6 GO:0050252 retinol O-fatty-acyltransferase activity(GO:0050252)
0.1 0.3 GO:0048257 3'-flap endonuclease activity(GO:0048257)
0.1 0.8 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.1 0.3 GO:0051377 mannose-ethanolamine phosphotransferase activity(GO:0051377)
0.1 0.8 GO:0043141 ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.1 0.3 GO:0019781 NEDD8 activating enzyme activity(GO:0019781)
0.1 1.3 GO:0031014 troponin T binding(GO:0031014)
0.1 0.9 GO:0003960 NADPH:quinone reductase activity(GO:0003960)
0.1 0.5 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.1 0.5 GO:0004797 thymidine kinase activity(GO:0004797)
0.1 3.4 GO:0008171 O-methyltransferase activity(GO:0008171)
0.1 0.3 GO:0008097 5S rRNA binding(GO:0008097)
0.1 0.3 GO:0031859 platelet activating factor receptor binding(GO:0031859)
0.1 0.3 GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.1 0.7 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.1 1.6 GO:0000150 recombinase activity(GO:0000150)
0.1 0.4 GO:0098625 methylselenol reductase activity(GO:0098625) methylseleninic acid reductase activity(GO:0098626)
0.1 0.2 GO:0032090 Pyrin domain binding(GO:0032090)
0.1 0.7 GO:0004689 phosphorylase kinase activity(GO:0004689)
0.1 0.3 GO:1990404 protein ADP-ribosylase activity(GO:1990404)
0.1 3.9 GO:0042974 retinoic acid receptor binding(GO:0042974)
0.1 1.3 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.1 0.8 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.1 0.6 GO:0004704 NF-kappaB-inducing kinase activity(GO:0004704)
0.1 0.8 GO:0102336 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.1 0.7 GO:0005329 dopamine transmembrane transporter activity(GO:0005329)
0.1 1.1 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.1 1.5 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.1 0.8 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
0.1 0.8 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.1 0.5 GO:1990446 U1 snRNP binding(GO:1990446)
0.0 0.3 GO:1990254 keratin filament binding(GO:1990254)
0.0 0.8 GO:0005344 oxygen transporter activity(GO:0005344)
0.0 0.8 GO:0070569 uridylyltransferase activity(GO:0070569)
0.0 0.2 GO:0035514 DNA demethylase activity(GO:0035514)
0.0 0.2 GO:0004936 alpha-adrenergic receptor activity(GO:0004936)
0.0 0.1 GO:0004925 prolactin receptor activity(GO:0004925)
0.0 0.4 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0 1.3 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.0 0.6 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 0.2 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.0 1.0 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 1.1 GO:1905030 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0 0.4 GO:0045029 UDP-activated nucleotide receptor activity(GO:0045029)
0.0 0.5 GO:0019826 oxygen sensor activity(GO:0019826)
0.0 0.3 GO:1904929 coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway(GO:1904929)
0.0 1.1 GO:0000217 DNA secondary structure binding(GO:0000217)
0.0 0.3 GO:0019103 pyrimidine nucleotide binding(GO:0019103)
0.0 0.3 GO:0030628 pre-mRNA 3'-splice site binding(GO:0030628)
0.0 0.7 GO:0035613 RNA stem-loop binding(GO:0035613)
0.0 0.1 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.0 0.1 GO:0004818 glutamate-tRNA ligase activity(GO:0004818)
0.0 0.6 GO:0036374 glutathione hydrolase activity(GO:0036374)
0.0 0.1 GO:0035651 AP-1 adaptor complex binding(GO:0035650) AP-3 adaptor complex binding(GO:0035651)
0.0 0.2 GO:0047820 D-glutamate cyclase activity(GO:0047820)
0.0 0.1 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.0 0.5 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.0 0.3 GO:0016018 cyclosporin A binding(GO:0016018)
0.0 0.1 GO:0004530 deoxyribonuclease I activity(GO:0004530)
0.0 1.1 GO:0070034 telomerase RNA binding(GO:0070034)
0.0 0.1 GO:0008745 N-acetylmuramoyl-L-alanine amidase activity(GO:0008745)
0.0 0.4 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.0 0.1 GO:0030984 kininogen binding(GO:0030984)
0.0 1.1 GO:0019200 carbohydrate kinase activity(GO:0019200)
0.0 1.3 GO:0030331 estrogen receptor binding(GO:0030331)
0.0 0.7 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.0 0.4 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.0 0.2 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0 0.1 GO:0016530 metallochaperone activity(GO:0016530)
0.0 0.2 GO:1990829 C-rich single-stranded DNA binding(GO:1990829)
0.0 0.2 GO:0015180 L-alanine transmembrane transporter activity(GO:0015180) alanine transmembrane transporter activity(GO:0022858)
0.0 0.3 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.0 0.2 GO:0051434 BH3 domain binding(GO:0051434)
0.0 0.2 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.0 0.1 GO:0015433 peptide antigen-transporting ATPase activity(GO:0015433)
0.0 0.5 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.0 0.1 GO:0008823 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.0 0.2 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250) ER retention sequence binding(GO:0046923)
0.0 0.9 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.0 1.8 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 0.2 GO:0004873 asialoglycoprotein receptor activity(GO:0004873)
0.0 0.1 GO:0051800 phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity(GO:0051800)
0.0 0.3 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.2 GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827)
0.0 0.1 GO:0050509 N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity(GO:0050509)
0.0 0.7 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.1 GO:0022865 transmembrane electron transfer carrier(GO:0022865)
0.0 0.3 GO:0031701 angiotensin receptor binding(GO:0031701) type 1 angiotensin receptor binding(GO:0031702)
0.0 0.8 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 1.0 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.0 0.5 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.3 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.0 0.9 GO:0003954 NADH dehydrogenase activity(GO:0003954)
0.0 0.1 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.0 0.4 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.0 0.9 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 0.1 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.0 0.1 GO:0061133 endopeptidase activator activity(GO:0061133)
0.0 0.3 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.0 0.2 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.0 1.4 GO:0005518 collagen binding(GO:0005518)
0.0 0.5 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 3.0 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 2.2 GO:0005319 lipid transporter activity(GO:0005319)
0.0 0.2 GO:0003688 DNA replication origin binding(GO:0003688)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.7 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.0 1.1 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.0 3.3 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.1 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.0 1.7 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.0 0.6 PID LYMPH ANGIOGENESIS PATHWAY VEGFR3 signaling in lymphatic endothelium
0.0 0.5 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.0 0.3 PID CXCR4 PATHWAY CXCR4-mediated signaling events
0.0 0.7 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 2.0 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 0.2 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.0 1.5 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.7 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.0 0.7 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 0.8 PID MYC PATHWAY C-MYC pathway
0.0 1.8 PID FGF PATHWAY FGF signaling pathway
0.0 0.3 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.2 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 0.6 ST B CELL ANTIGEN RECEPTOR B Cell Antigen Receptor
0.0 0.4 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 0.2 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 1.1 PID P53 REGULATION PATHWAY p53 pathway
0.0 0.5 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 0.3 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.7 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.1 1.9 REACTOME FGFR4 LIGAND BINDING AND ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.1 1.3 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.1 2.3 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.1 0.8 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.0 2.0 REACTOME EXTENSION OF TELOMERES Genes involved in Extension of Telomeres
0.0 1.3 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 1.0 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 2.6 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.7 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.0 1.7 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 0.5 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 0.4 REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL Genes involved in NF-kB is activated and signals survival
0.0 0.6 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 0.8 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.0 0.7 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.6 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 0.5 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.0 1.4 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.4 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 0.2 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 0.6 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 0.6 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.0 0.5 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
0.0 0.2 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0 0.4 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
0.0 0.9 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 0.6 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 0.2 REACTOME G PROTEIN ACTIVATION Genes involved in G-protein activation
0.0 0.8 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.4 REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX Genes involved in Activation of the pre-replicative complex
0.0 0.4 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.2 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.5 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.7 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.7 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels