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SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for RCOR1_MTA3
Z-value: 1.49
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Transcription factors associated with RCOR1_MTA3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| RCOR1 | hg19_v2_chr14_+_103058948_103059005 | 0.79 | 3.1e-05 | Click! |
| MTA3 | hg19_v2_chr2_+_42795839_42795887 | 0.73 | 2.5e-04 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of RCOR1_MTA3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 36.9 | GO:0007062 | sister chromatid cohesion(GO:0007062) |
| 0.2 | 18.7 | GO:0006334 | nucleosome assembly(GO:0006334) |
| 0.2 | 17.9 | GO:0006368 | transcription elongation from RNA polymerase II promoter(GO:0006368) |
| 0.8 | 17.0 | GO:0051988 | regulation of attachment of spindle microtubules to kinetochore(GO:0051988) |
| 0.4 | 14.9 | GO:0061641 | CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641) |
| 0.3 | 13.9 | GO:0000281 | mitotic cytokinesis(GO:0000281) |
| 0.4 | 13.1 | GO:0032201 | telomere maintenance via semi-conservative replication(GO:0032201) |
| 0.4 | 12.1 | GO:1902857 | positive regulation of nonmotile primary cilium assembly(GO:1902857) |
| 0.6 | 10.3 | GO:0090168 | Golgi reassembly(GO:0090168) |
| 0.4 | 10.1 | GO:1904776 | regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 79.5 | GO:0005829 | cytosol(GO:0005829) |
| 0.3 | 44.2 | GO:0000922 | spindle pole(GO:0000922) |
| 0.1 | 41.6 | GO:0030027 | lamellipodium(GO:0030027) |
| 0.3 | 35.0 | GO:0000776 | kinetochore(GO:0000776) |
| 0.0 | 29.9 | GO:0005730 | nucleolus(GO:0005730) |
| 0.3 | 20.7 | GO:0005876 | spindle microtubule(GO:0005876) |
| 0.5 | 19.4 | GO:0032156 | septin cytoskeleton(GO:0032156) |
| 0.4 | 17.9 | GO:0035371 | microtubule plus-end(GO:0035371) |
| 0.4 | 17.1 | GO:0097431 | mitotic spindle pole(GO:0097431) |
| 0.2 | 17.1 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 94.7 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.2 | 49.2 | GO:0042393 | histone binding(GO:0042393) |
| 0.1 | 31.2 | GO:0061659 | ubiquitin-like protein ligase activity(GO:0061659) |
| 0.1 | 28.4 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.1 | 24.4 | GO:0005525 | GTP binding(GO:0005525) |
| 0.2 | 23.5 | GO:0019783 | ubiquitin-like protein-specific protease activity(GO:0019783) |
| 0.1 | 19.8 | GO:0017048 | Rho GTPase binding(GO:0017048) |
| 0.2 | 15.0 | GO:0019003 | GDP binding(GO:0019003) |
| 0.2 | 14.8 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.4 | 14.3 | GO:0017056 | structural constituent of nuclear pore(GO:0017056) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 52.0 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.3 | 41.4 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.5 | 37.0 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.5 | 31.4 | PID ATR PATHWAY | ATR signaling pathway |
| 0.3 | 24.9 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.4 | 22.0 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.3 | 17.8 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.1 | 14.8 | PID E2F PATHWAY | E2F transcription factor network |
| 0.1 | 14.0 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.3 | 13.3 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 62.7 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.1 | 28.3 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.5 | 25.5 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.3 | 25.5 | REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.4 | 23.8 | REACTOME RECYCLING PATHWAY OF L1 | Genes involved in Recycling pathway of L1 |
| 0.5 | 22.5 | REACTOME DOUBLE STRAND BREAK REPAIR | Genes involved in Double-Strand Break Repair |
| 0.4 | 20.5 | REACTOME TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT | Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript |
| 0.2 | 20.1 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.4 | 19.8 | REACTOME TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS | Genes involved in TGF-beta receptor signaling activates SMADs |
| 0.2 | 17.6 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |